|
Name |
Accession |
Description |
Interval |
E-value |
| sbcc |
TIGR00618 |
exonuclease SbcC; All proteins in this family for which functions are known are part of an ... |
1-1010 |
2.18e-68 |
|
exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 129705 [Multi-domain] Cd Length: 1042 Bit Score: 248.35 E-value: 2.18e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 1 MRPIKLTLQAFGPFASQEVVDFTELGHapLFLINGPTGAGKSSILDAICYAMYGETTGSERTGDQMRCDYAEEGLLTEIQ 80
Cdd:TIGR00618 1 MKPLRLTLKNFGSYKGTHTIDFTALGP--IFLICGKTGAGKTTLLDAITYALYGKLPRRSEVIRSLNSLYAAPSEAAFAE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 81 FMFQLNGRVFNVTRSPDQEVPKKRGEgttkkshsaTLCEIVEGEE----KLLANRPSPVAKAMVDLIGLDVKQFRQVMVI 156
Cdd:TIGR00618 79 LEFSLGTKIYRVHRTLRCTRSHRKTE---------QPEQLYLEQKkgrgRILAAKKSETEEVIHDLLKLDYKTFTRVVLL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 157 PQGKFRELLIANSKEREQIFGQLFQTHIYTQIERTLFERAAGIRKEKDEFDNQIKGaLDVVSVSSEEELKDEKSKLAPVL 236
Cdd:TIGR00618 150 PQGEFAQFLKAKSKEKKELLMNLFPLDQYTQLALMEFAKKKSLHGKAELLTLRSQL-LTLCTPCMPDTYHERKQVLEKEL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 237 KEAEISYQAAQTSLDTVKQQHgaaiELQQKFAQKEALDKELQLEVAKQSEMDVVRARKQQALQAARLDSPFNEMNAAEKQ 316
Cdd:TIGR00618 229 KHLREALQQTQQSHAYLTQKR----EAQEEQLKKQQLLKQLRARIEELRAQEAVLEETQERINRARKAAPLAAHIKAVTQ 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 317 LNQAQSAVVARtdaVALATKQVTEADTVYQAAISNCSQLESLTAQLHQLEATGKKFAALDEQQKQLAAASQLFTSAKHAF 396
Cdd:TIGR00618 305 IEQQAQRIHTE---LQSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIREISCQQHTLTQHI 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 397 QQAESALQTLDQQIQVKRKEKEAAQLQLATLDSQRSSLNIISEHIERRTRLQQLTQQLHDKAQLH-----QQAEQAYKEA 471
Cdd:TIGR00618 382 HTLQQQKTTLTQKLQSLCKELDILQREQATIDTRTSAFRDLQGQLAHAKKQQELQQRYAELCAAAitctaQCEKLEKIHL 461
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 472 QEKTRLAKQRADQL-------EYVWHTNQAAELAKLLQEGDACPVCGSHSHPQLAQFSGDVV------------------ 526
Cdd:TIGR00618 462 QESAQSLKEREQQLqtkeqihLQETRKKAVVLARLLELQEEPCPLCGSCIHPNPARQDIDNPgpltrrmqrgeqtyaqle 541
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 527 -----TKEQVQQARDHQQTAANTETQALKRHEALTAEHQHLKQDVELLETAIKEKRIPELAELHAKQTQLTTEIARLQAL 601
Cdd:TIGR00618 542 tseedVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQDLTEKLSEAEDMLACEQHALLRKL 621
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 602 NPAQLEQQLQQLEFSFNAAKQTLDNQLAARQTA----EIAVAEAQTRVNDLQ---------RDITSEFTHVDEVRQRYSQ 668
Cdd:TIGR00618 622 QPEQDLQDVRLHLQQCSQELALKLTALHALQLTltqeRVREHALSIRVLPKEllasrqlalQKMQSEKEQLTYWKEMLAQ 701
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 669 VQKQIKALTEAEQQARAALNAAQNQLSSAQAALASAQEQHTSWSREVKRAQQQWQQALAETPFADREAYLAAKLDDQALA 748
Cdd:TIGR00618 702 CQTLLRELETHIEEYDREFNEIENASSSLGSDLAAREDALNQSLKELMHQARTVLKARTEAHFNNNEEVTAALQTGAELS 781
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 749 ALDEQLRRFDEGLATLKGKLESLVQSLADKTlpqMENLESALAERQSAVTAAFNVLAVHRSRMDSLVQVEQKLARLYEKN 828
Cdd:TIGR00618 782 HLAAEIQFFNRLREEDTHLLKTLEAEIGQEI---PSDEDILNLQCETLVQEEEQFLSRLEEKSATLGEITHQLLKYEECS 858
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 829 AELDKAYQVYG---TLSDIANGRTGAKVSLHRFVLGVLLDDVLIQASQRLQMMSKGRYLLKRKEERAKGNAGSGLDLMVE 905
Cdd:TIGR00618 859 KQLAQLTQEQAkiiQLSDKLNGINQIKIQFDGDALIKFLHEITLYANVRLANQSEGRFHGRYADSHVNARKYQGLALLVA 938
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 906 DGYTGKWRDVATLSGGESFMAALSLALGLSDVVQSySGGIRLDTLFIDEGFGSLDPESLDLAIQTLIDLQQGGRTIGIIS 985
Cdd:TIGR00618 939 DAYTGSVRPSATLSGGETFLASLSLALALADLLST-SGGTVLDSLFIDEGFGSLDEDSLDRAIGILDAIREGSKMIGIIS 1017
|
1050 1060
....*....|....*....|....*
gi 2176024252 986 HVTELKEQISLRLDVETSGRGSSIK 1010
Cdd:TIGR00618 1018 HVPEFRERIPHRILVKKTNAGSHVM 1042
|
|
| PRK10246 |
PRK10246 |
exonuclease subunit SbcC; Provisional |
20-1000 |
4.81e-53 |
|
exonuclease subunit SbcC; Provisional
Pssm-ID: 182330 [Multi-domain] Cd Length: 1047 Bit Score: 201.95 E-value: 4.81e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 20 VDFTELGHAP--LFLINGPTGAGKSSILDAICYAMYGET----TGSERTGDQMRCDYAEegLLTEIQFmfQLNGRVFNVT 93
Cdd:PRK10246 20 IDFTAEPFASngLFAITGPTGAGKTTLLDAICLALYHETprlnNVSQSQNDLMTRDTAE--CLAEVEF--EVKGEAYRAF 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 94 RSpdqevpKKRGEGTTKKSHSATLCEIVEGEE-KLLANRPSPVAKAMVDLIGLDVKQFRQVMVIPQGKFRELLIANSKER 172
Cdd:PRK10246 96 WS------QNRARNQPDGNLQAPRVELARCADgKILADKVKDKLELTATLTGLDYGRFTRSMLLSQGQFAAFLNAKPKER 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 173 EQIFGQLFQTHIYTQIERTLFERAAGIRKEKDEFDNQIKGaldvVSVSSEEELKDEKSKLApVLKEAEISYQAAQTSLdt 252
Cdd:PRK10246 170 AELLEELTGTEIYGQISAMVFEQHKSARTELEKLQAQASG----VALLTPEQVQSLTASLQ-VLTDEEKQLLTAQQQQ-- 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 253 vkQQHgaaielQQKFAQKEALDKELQLEVAKQSEMDVVRARKQQALQAARLDSPFNEMNAAEKQLnQAQSAVVARTDAVA 332
Cdd:PRK10246 243 --QQS------LNWLTRLDELQQEASRRQQALQQALAAEEKAQPQLAALSLAQPARQLRPHWERI-QEQSAALAHTRQQI 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 333 LATKQVTEADTVYQAAISNCSQLESlTAQLHQLEATGKKFAALDEQQ---KQLAAASQLFTSAKHAFQQaesaLQTLDQQ 409
Cdd:PRK10246 314 EEVNTRLQSTMALRARIRHHAAKQS-AELQAQQQSLNTWLAEHDRFRqwnNELAGWRAQFSQQTSDREQ----LRQWQQQ 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 410 IQVKRKEKEA------------AQLQLATLDSQRSSLNIISEHIERRTRLQQLTQQLHDKAQLHQQAEQAYKEAQEKTRL 477
Cdd:PRK10246 389 LTHAEQKLNAlpaitltltadeVAAALAQHAEQRPLRQRLVALHGQIVPQQKRLAQLQVAIQNVTQEQTQRNAALNEMRQ 468
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 478 A-KQRADQLEYVWHT-NQAAELAKL------LQEGDACPVCGSHSHPQLAQFSGDVVTKEQVQQARDHQQTAANTETQAL 549
Cdd:PRK10246 469 RyKEKTQQLADVKTIcEQEARIKDLeaqraqLQAGQPCPLCGSTSHPAVEAYQALEPGVNQSRLDALEKEVKKLGEEGAA 548
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 550 KRHEaLTAEHQHLKQDVELLETAIKEkripELAELHAKQT---QLTTEIARLQALNPAQLEQQLQQLEFSFNAAKQTLDN 626
Cdd:PRK10246 549 LRGQ-LDALTKQLQRDESEAQSLRQE----EQALTQQWQAvcaSLNITLQPQDDIQPWLDAQEEHERQLRLLSQRHELQG 623
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 627 QLAArQTAEIAVAEAQ--TRVNDLQRDIT--------------------SEFTHVDEVRQRYSQVQKQIKALT------- 677
Cdd:PRK10246 624 QIAA-HNQQIIQYQQQieQRQQQLLTALAgyaltlpqedeeaswlatrqQEAQSWQQRQNELTALQNRIQQLTplletlp 702
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 678 -------EAEQQARAALNAAQNQLSSAQAALASAQEQHTSWSREVKRAQQQWQQALAETPFADREAYLAAKLDDQALAAL 750
Cdd:PRK10246 703 qsddlphSEETVALDNWRQVHEQCLSLHSQLQTLQQQDVLEAQRLQKAQAQFDTALQASVFDDQQAFLAALLDEETLTQL 782
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 751 DEQLRRFDEGLATLKGKLESLVQSLADKTLPQMENLESALAERQSAvtAAFNVLAvHRSRMDSLVQVE------------ 818
Cdd:PRK10246 783 EQLKQNLENQRQQAQTLVTQTAQALAQHQQHRPDGLDLTVTVEQIQ--QELAQLA-QQLRENTTRQGEirqqlkqdadnr 859
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 819 QKLARLYEKNAELDKAYQVYGTLSDIANGRTGAKvsLHRFVLGVLLDDVLIQASQRLQMMsKGRYLLKRKeerakgnAGS 898
Cdd:PRK10246 860 QQQQALMQQIAQATQQVEDWGYLNSLIGSKEGDK--FRKFAQGLTLDNLVWLANQQLTRL-HGRYLLQRK-------ASE 929
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 899 GLDLMVEDGYTGKW-RDVATLSGGESFMAALSLALGLSDVVqsySGGIRLDTLFIDEGFGSLDPESLDLAIQTLIDLQQG 977
Cdd:PRK10246 930 ALELEVVDTWQADAvRDTRTLSGGESFLVSLALALALSDLV---SHKTRIDSLFLDEGFGTLDSETLDTALDALDALNAS 1006
|
1050 1060
....*....|....*....|...
gi 2176024252 978 GRTIGIISHVTELKEQISLRLDV 1000
Cdd:PRK10246 1007 GKTIGVISHVEAMKERIPVQIKV 1029
|
|
| ABC_sbcCD |
cd03279 |
ATP-binding cassette domain of sbcCD; SbcCD and other Mre11/Rad50 (MR) complexes are ... |
913-1008 |
9.72e-38 |
|
ATP-binding cassette domain of sbcCD; SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini.
Pssm-ID: 213246 [Multi-domain] Cd Length: 213 Bit Score: 140.87 E-value: 9.72e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 913 RDVATLSGGESFMAALSLALGLSDVVQSySGGIRLDTLFIDEGFGSLDPESLDLAIQTLIDLQQGGRTIGIISHVTELKE 992
Cdd:cd03279 119 RPVSTLSGGETFLASLSLALALSEVLQN-RGGARLEALFIDEGFGTLDPEALEAVATALELIRTENRMVGVISHVEELKE 197
|
90
....*....|....*.
gi 2176024252 993 QISLRLDVETSGRGSS 1008
Cdd:cd03279 198 RIPQRLEVIKTPGGSR 213
|
|
| ABC_sbcCD |
cd03279 |
ATP-binding cassette domain of sbcCD; SbcCD and other Mre11/Rad50 (MR) complexes are ... |
1-166 |
6.09e-34 |
|
ATP-binding cassette domain of sbcCD; SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini.
Pssm-ID: 213246 [Multi-domain] Cd Length: 213 Bit Score: 129.70 E-value: 6.09e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 1 MRPIKLTLQAFGPFASQEVVDFTELGHAPLFLINGPTGAGKSSILDAICYAMYGETTGSERTGDqMRCDYAEEGLLTEIQ 80
Cdd:cd03279 1 MKPLKLELKNFGPFREEQVIDFTGLDNNGLFLICGPTGAGKSTILDAITYALYGKTPRYGRQEN-LRSVFAPGEDTAEVS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 81 FMFQLNGRVFNVTRSPdqevpkkrgegttkkshsatlceivegeekllanrpspvakamvdliGLDVKQFRQVMVIPQGK 160
Cdd:cd03279 80 FTFQLGGKKYRVERSR-----------------------------------------------GLDYDQFTRIVLLPQGE 112
|
....*.
gi 2176024252 161 FRELLI 166
Cdd:cd03279 113 FDRFLA 118
|
|
| SbcC |
COG0419 |
DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]; |
2-211 |
1.39e-26 |
|
DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair];
Pssm-ID: 440188 [Multi-domain] Cd Length: 204 Bit Score: 108.17 E-value: 1.39e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 2 RPIKLTLQAFGPFASQEVVDFTelghAPLFLINGPTGAGKSSILDAICYAMYGETTGSERTGDQMRCDYAEEgllTEIQF 81
Cdd:COG0419 1 KLLRLRLENFRSYRDTETIDFD----DGLNLIVGPNGAGKSTILEAIRYALYGKARSRSKLRSDLINVGSEE---ASVEL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 82 MFQLNGRVFNVTRspdqevpkkrgegttkkshsatlceivegeekllanrpspvakamvdligldvkqfrqvmviPQGKF 161
Cdd:COG0419 74 EFEHGGKRYRIER--------------------------------------------------------------RQGEF 91
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 2176024252 162 RELLIANSKEREQIFGQLFQTHIYTQIERTLFERAAGIRKEKDEFDNQIK 211
Cdd:COG0419 92 AEFLEAKPSERKEALKRLLGLEIYEELKERLKELEEALESALEELAELQK 141
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
355-986 |
2.59e-16 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 83.66 E-value: 2.59e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 355 LESLTAQLHQLE-ATGKKFAALDEQQKQLAAASQLFTSAKHAFQQAESALQTLDQQIQVKRKEKEAAQLQLATLDSQRSS 433
Cdd:COG4717 48 LERLEKEADELFkPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQL 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 434 LNIISEHIERRTRLQQLTQQLHDkaqlHQQAEQAYKEAQEKTRLAKQRADQLEyvwhtnqaAELAKLLQEGDAcpvcgsH 513
Cdd:COG4717 128 LPLYQELEALEAELAELPERLEE----LEERLEELRELEEELEELEAELAELQ--------EELEELLEQLSL------A 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 514 SHPQLAQFSGDVVT-KEQVQQARDHQQTAANTETQALKRHEALTAEHQHLKQDVELLETAIKEKRIPELAELHAKQTQLT 592
Cdd:COG4717 190 TEEELQDLAEELEElQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEARLLLLIAAALLALLGLGGSLL 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 593 TEIARLQALNPAQLEQQLQQLEFSFNAAKQTLDNQLAARQTAEIAVAEAQTRVNDLQRDITSEFTHVDEVRQRYSQVQKQ 672
Cdd:COG4717 270 SLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEEL 349
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 673 IKALTEAEQQARAAlnaaqnqlssaqaalasaqeqhtswsrEVKRAQQQWQQALAETPFADREAYLAAKLDDQALAALDE 752
Cdd:COG4717 350 QELLREAEELEEEL---------------------------QLEELEQEIAALLAEAGVEDEEELRAALEQAEEYQELKE 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 753 QLRRFDEGLATLKGKLESLVQSLADKTLP-QMENLESALAERQSAVTAAFNVLAVHRSRM------DSLVQVEQKLARLY 825
Cdd:COG4717 403 ELEELEEQLEELLGELEELLEALDEEELEeELEELEEELEELEEELEELREELAELEAELeqleedGELAELLQELEELK 482
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 826 EKNAELDKAYQVYGTLSDIANgrtgakvSLHRFVLGVLLDDVLIQASQRLQMMSKGRYLLKRKEErakgnagsGLDLMVE 905
Cdd:COG4717 483 AELRELAEEWAALKLALELLE-------EAREEYREERLPPVLERASEYFSRLTDGRYRLIRIDE--------DLSLKVD 547
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 906 DGyTGKWRDVATLSGGESFMAALSLALGLSDVVQSYSGgirldTLFIDEGFGSLDPESLDLAIQTLIDLQQGGRTIGIIS 985
Cdd:COG4717 548 TE-DGRTRPVEELSRGTREQLYLALRLALAELLAGEPL-----PLILDDAFVNFDDERLRAALELLAELAKGRQVIYFTC 621
|
.
gi 2176024252 986 H 986
Cdd:COG4717 622 H 622
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
155-831 |
3.42e-16 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 83.83 E-value: 3.42e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 155 VIPQGKFRELLIANSKEReqifgqlfqthiytqieRTLFERAAGI-----RKEKDEfdNQIKGA-------LDVVsvsse 222
Cdd:COG1196 140 IIGQGMIDRIIEAKPEER-----------------RAIIEEAAGIskykeRKEEAE--RKLEATeenlerlEDIL----- 195
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 223 EELKDEKSKLApvlKEAEI--SYQAAQTSLDtVKQQHGAAIELQQKFAQKEALDKELQLEVAKQSEMDVVRARKQQALQA 300
Cdd:COG1196 196 GELERQLEPLE---RQAEKaeRYRELKEELK-ELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEE 271
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 301 ARLdspfnEMNAAEKQLNQAQSAVVARTDAVALATKQVTEADtvyQAAISNCSQLESLTAQLHQLEATGKKFAA-LDEQQ 379
Cdd:COG1196 272 LRL-----ELEELELELEEAQAEEYELLAELARLEQDIARLE---ERRRELEERLEELEEELAELEEELEELEEeLEELE 343
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 380 KQLAAASQLFTSAKHAFQQAESALQTLDQQIQVKRKEKEAAQLQLATLDSQRsslniisehIERRTRLQQLTQQLHDKAQ 459
Cdd:COG1196 344 EELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAA---------AELAAQLEELEEAEEALLE 414
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 460 LHQQAEQAYKEAQEKTRLAKQRADQLEyVWHTNQAAELAKLLQEGDAcpvcgshshpQLAQFSGDVVTKEQVQQARDHQQ 539
Cdd:COG1196 415 RLERLEEELEELEEALAELEEEEEEEE-EALEEAAEEEAELEEEEEA----------LLELLAELLEEAALLEAALAELL 483
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 540 TAANTETQALKRHEALTAEHQHLKQDVELLETAIKEKRI-PELAELHAKQTQLTTEI-ARLQALNPAQLEQQLQQLEFSF 617
Cdd:COG1196 484 EELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLaGAVAVLIGVEAAYEAALeAALAAALQNIVVEDDEVAAAAI 563
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 618 NAAKQTLDNQLAARQTAEIAVAEAQTRVNDLQRdITSEFTHVDEVRQRYSQVQKQIKALTEAEQQARAALNAAQNQLSSA 697
Cdd:COG1196 564 EYLKAAKAGRATFLPLDKIRARAALAAALARGA-IGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTL 642
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 698 QAALASAQEQHTSWSREVKRAQQQWQQALAETPFADREAYLAAKLDDQALAALDEQLRRFDEGLATLKGKLESLVQSLAD 777
Cdd:COG1196 643 AGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELE 722
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|....*..
gi 2176024252 778 KTLPQMENL---ESALAERQSAVTAAFNVLAVHRSRMDSLVQVEQKLARLYEKNAEL 831
Cdd:COG1196 723 EEALEEQLEaerEELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIEAL 779
|
|
| ABC_Rad50 |
cd03240 |
ATP-binding cassette domain of Rad50; The catalytic domains of Rad50 are similar to the ... |
5-98 |
1.60e-14 |
|
ATP-binding cassette domain of Rad50; The catalytic domains of Rad50 are similar to the ATP-binding cassette of ABC transporters, but are not associated with membrane-spanning domains. The conserved ATP-binding motifs common to Rad50 and the ABC transporter family include the Walker A and Walker B motifs, the Q loop, a histidine residue in the switch region, a D-loop, and a conserved LSGG sequence. This conserved sequence, LSGG, is the most specific and characteristic motif of this family and is thus known as the ABC signature sequence.
Pssm-ID: 213207 [Multi-domain] Cd Length: 204 Bit Score: 73.41 E-value: 1.60e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 5 KLTLQAFGPFASQEVVDFTElghaPLFLINGPTGAGKSSILDAICYAMYGETTGSERTGDQMRCDYAEEGLLTEIQFMFQ 84
Cdd:cd03240 3 KLSIRNIRSFHERSEIEFFS----PLTLIVGQNGAGKTTIIEALKYALTGELPPNSKGGAHDPKLIREGEVRAQVKLAFE 78
|
90
....*....|....*
gi 2176024252 85 L-NGRVFNVTRSPDQ 98
Cdd:cd03240 79 NaNGKKYTITRSLAI 93
|
|
| AAA_23 |
pfam13476 |
AAA domain; |
6-211 |
1.83e-14 |
|
AAA domain;
Pssm-ID: 463890 [Multi-domain] Cd Length: 190 Bit Score: 72.91 E-value: 1.83e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 6 LTLQAFGPFASQEVvDFtelgHAPLFLINGPTGAGKSSILDAICYAMYGET--TGSERTGDQMRCDYA---EEGLLTEIQ 80
Cdd:pfam13476 1 LTIENFRSFRDQTI-DF----SKGLTLITGPNGSGKTTILDAIKLALYGKTsrLKRKSGGGFVKGDIRiglEGKGKAYVE 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 81 FMFQLNGRVFNVTRSPDQEVPKKRGEGTTKKSHSatLCEIVEGEEKLLanrpspvakamvDLIGLDVKQFRQVMVIPQGK 160
Cdd:pfam13476 76 ITFENNDGRYTYAIERSRELSKKKGKTKKKEILE--ILEIDELQQFIS------------ELLKSDKIILPLLVFLGQER 141
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 2176024252 161 FRELLIANSKEREQIFGQLFQTHIYtqiERTLFERAAGIRKEKDEFDNQIK 211
Cdd:pfam13476 142 EEEFERKEKKERLEELEKALEEKED---EKKLLEKLLQLKEKKKELEELKE 189
|
|
| ABC_Rad50 |
cd03240 |
ATP-binding cassette domain of Rad50; The catalytic domains of Rad50 are similar to the ... |
913-1009 |
2.60e-14 |
|
ATP-binding cassette domain of Rad50; The catalytic domains of Rad50 are similar to the ATP-binding cassette of ABC transporters, but are not associated with membrane-spanning domains. The conserved ATP-binding motifs common to Rad50 and the ABC transporter family include the Walker A and Walker B motifs, the Q loop, a histidine residue in the switch region, a D-loop, and a conserved LSGG sequence. This conserved sequence, LSGG, is the most specific and characteristic motif of this family and is thus known as the ABC signature sequence.
Pssm-ID: 213207 [Multi-domain] Cd Length: 204 Bit Score: 72.64 E-value: 2.60e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 913 RDVATLSGGESFMAALSLALGLSDVVqsysgGIRLDTLFIDEGFGSLDPESLDLAIQTLIDLQ--QGGRTIGIISHVTEL 990
Cdd:cd03240 111 DMRGRCSGGEKVLASLIIRLALAETF-----GSNCGILALDEPTTNLDEENIEESLAEIIEERksQKNFQLIVITHDEEL 185
|
90
....*....|....*....
gi 2176024252 991 KEQISLRLDVETSGRGSSI 1009
Cdd:cd03240 186 VDAADHIYRVEKDGRQKSR 204
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
354-834 |
1.41e-12 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 71.89 E-value: 1.41e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 354 QLESLTAQLHQLEATgkkfaaLDEQQKQLAAASQLFTSAKHAFQQAESALQTLDQQIQVKRKEKEAAQLQLATLDSQRSS 433
Cdd:COG1196 226 EAELLLLKLRELEAE------LEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELAR 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 434 LNIISEHIERR-----TRLQQLTQQLHDKAQLHQQAEQAYKEAQEKTRLAKQRADQLEYVWHTNQAAELAKLLQEGDAcp 508
Cdd:COG1196 300 LEQDIARLEERrreleERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEA-- 377
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 509 vcgshshpQLAQFSgdvvTKEQVQQARDHQQTAANTETQALKRHEALTAEHQHLKQDVELLETAIKEKRIPELAELHAKQ 588
Cdd:COG1196 378 --------EEELEE----LAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALE 445
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 589 TQLTTEIARLQALNPAQLEQQLQQLEFSFNAAKQTLDNQLAARQTAEIAVAEAQTRVNDLQRDITSEFTHVDEVRQRYSQ 668
Cdd:COG1196 446 EAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGA 525
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 669 VQKQIKALTEAEQQARAALNAAQNQLSSAQAALASAQEQhtsWSREVKRAQQQWQQALAETPFADREAYLAAKLDDQALA 748
Cdd:COG1196 526 VAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIE---YLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVD 602
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 749 ALDEQLRRFDEGLATLkgKLESLVQSLADKTLPQMENLESALAERQSAVTAAfnVLAVHRSRMDSLVQVEQKLARLYEKN 828
Cdd:COG1196 603 LVASDLREADARYYVL--GDTLLGRTLVAARLEAALRRAVTLAGRLREVTLE--GEGGSAGGSLTGGSRRELLAALLEAE 678
|
....*.
gi 2176024252 829 AELDKA 834
Cdd:COG1196 679 AELEEL 684
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
373-893 |
3.62e-12 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 70.74 E-value: 3.62e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 373 AALDEQQKQLAAasqlftsakHAFQQAESALQTLDQQIQVKRKEKEAAQLQLATLDSQRSSLNiiSEHIERRTRLQQLTQ 452
Cdd:COG1196 220 EELKELEAELLL---------LKLRELEAELEELEAELEELEAELEELEAELAELEAELEELR--LELEELELELEEAQA 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 453 QLHDKAQLHQQAEQAYKEAQEKTRLAKQRADQLEyvwhtNQAAELAKLLQEGDAcpvcgshshpQLAQFSGDVVTKEQVQ 532
Cdd:COG1196 289 EEYELLAELARLEQDIARLEERRRELEERLEELE-----EELAELEEELEELEE----------ELEELEEELEEAEEEL 353
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 533 QARDHQQTAANTETQAL--KRHEALTAEHQHLKQDVELLETAIKEKRipELAELHAKQTQLTTEIARLQALNpaqleqql 610
Cdd:COG1196 354 EEAEAELAEAEEALLEAeaELAEAEEELEELAEELLEALRAAAELAA--QLEELEEAEEALLERLERLEEEL-------- 423
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 611 qqlefsfNAAKQTLDNQLAARQTAEIAVAEAQTRVNDLQRDITSEFTHVDEVRQRYSQVQKQIKALTEAEQQARAALNAA 690
Cdd:COG1196 424 -------EELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLL 496
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 691 QNQLSSAQAALASAQEQHTSWSREVKRAQQQWQQALAETPFADREAYLAAKL------DDQALAALDEQLRRFDEGLATL 764
Cdd:COG1196 497 LEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALqnivveDDEVAAAAIEYLKAAKAGRATF 576
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 765 KGKLESLVQSLADKTLPQMENLESALAERQSAVTAAfnvlAVHRSRMDSLVQVEQKLARLYEKNAELDKAYQVYGTLSDI 844
Cdd:COG1196 577 LPLDKIRARAALAAALARGAIGAAVDLVASDLREAD----ARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLE 652
|
490 500 510 520
....*....|....*....|....*....|....*....|....*....
gi 2176024252 845 ANGRTGAKVSLHRFVLGVLLDDVLIQASQRLQMMSKGRYLLKRKEERAK 893
Cdd:COG1196 653 GEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLA 701
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
155-484 |
4.96e-11 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 67.00 E-value: 4.96e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 155 VIPQGKFRELLIANSKEReqifgqlfqthiytqieRTLFERAAGI---RKEKDEFDNQIkgaldvvsVSSEEELKdeksK 231
Cdd:TIGR02168 140 IIEQGKISEIIEAKPEER-----------------RAIFEEAAGIskyKERRKETERKL--------ERTRENLD----R 190
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 232 LAPVLKEAEisyqaaqTSLDTVKQQHGAAIELQQKFAQKEALDKEL----------QLEVAKQSEMDVVRARKQQALQAA 301
Cdd:TIGR02168 191 LEDILNELE-------RQLKSLERQAEKAERYKELKAELRELELALlvlrleelreELEELQEELKEAEEELEELTAELQ 263
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 302 RLDSPFNE----MNAAEKQLNQAQSAVVARTDAVALATKQVTEADTVYQAAISNCSQLE-SLTAQLHQLEATGKKFAALD 376
Cdd:TIGR02168 264 ELEEKLEElrleVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEaQLEELESKLDELAEELAELE 343
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 377 EQ----QKQLAAASQLFTSAKHAFQQAESALQTLDQQIQVKRKEKEAAQLQLATLDSQRSSLNIISEHIE-RRTRLQQLT 451
Cdd:TIGR02168 344 EKleelKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEdRRERLQQEI 423
|
330 340 350
....*....|....*....|....*....|...
gi 2176024252 452 QQLHDKAQLHQQAEQAYKEAQEKTRLAKQRADQ 484
Cdd:TIGR02168 424 EELLKKLEEAELKELQAELEELEEELEELQEEL 456
|
|
| PRK01156 |
PRK01156 |
chromosome segregation protein; Provisional |
32-592 |
6.87e-11 |
|
chromosome segregation protein; Provisional
Pssm-ID: 100796 [Multi-domain] Cd Length: 895 Bit Score: 66.46 E-value: 6.87e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 32 LINGPTGAGKSSILDAICYAMYGETTgSERTGDQMRcdYAEEGLltEIQFMFQLNGRVFNVTRSPDqevpkKRGEGTTKK 111
Cdd:PRK01156 27 IITGKNGAGKSSIVDAIRFALFTDKR-TEKIEDMIK--KGKNNL--EVELEFRIGGHVYQIRRSIE-----RRGKGSRRE 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 112 SHsatlceiVEGEEKLLANRPSPVAKAM-VDLIGLDVKQFRQVMVIPQGKFRELLIANSKEREQIFGQLFqthiytQIER 190
Cdd:PRK01156 97 AY-------IKKDGSIIAEGFDDTTKYIeKNILGISKDVFLNSIFVGQGEMDSLISGDPAQRKKILDEIL------EINS 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 191 TlferAAGIRKEKDEFDNQIKGALDVVSVssEEELKDEKSKLAPVLKEAEisyQAAQTSLDTVKQQHGAAIELQQKFAQK 270
Cdd:PRK01156 164 L----ERNYDKLKDVIDMLRAEISNIDYL--EEKLKSSNLELENIKKQIA---DDEKSHSITLKEIERLSIEYNNAMDDY 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 271 EALDKEL-----QLEVAKQSEMDVVRARKQQALQAARLdspfNEMNAAEKQLNQAQSavvartDAVALATKQVTEADTVY 345
Cdd:PRK01156 235 NNLKSALnelssLEDMKNRYESEIKTAESDLSMELEKN----NYYKELEERHMKIIN------DPVYKNRNYINDYFKYK 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 346 QAAISNCSQLESLTAQLHQLEATGKKFAALD-------EQQKQLAAASQLFTSAKHAFQQAESALQTLdQQIQVKRKEKE 418
Cdd:PRK01156 305 NDIENKKQILSNIDAEINKYHAIIKKLSVLQkdyndyiKKKSRYDDLNNQILELEGYEMDYNSYLKSI-ESLKKKIEEYS 383
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 419 AAQLQLATLDSQRSSLNIISEHiERRTRLQQLTQQLhdkaqlhQQAEQAYKEAQEKTRLAKQRADQLEyvwhtnqaaELA 498
Cdd:PRK01156 384 KNIERMSAFISEILKIQEIDPD-AIKKELNEINVKL-------QDISSKVSSLNQRIRALRENLDELS---------RNM 446
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 499 KLLQEGDACPVCGSHshpqlaqfsgdvVTKEQVQQARDHQQTAANTETQALKRHE----ALTAEHQHLKQDVELLETAIK 574
Cdd:PRK01156 447 EMLNGQSVCPVCGTT------------LGEEKSNHIINHYNEKKSRLEEKIREIEievkDIDEKIVDLKKRKEYLESEEI 514
|
570
....*....|....*...
gi 2176024252 575 EKRIPELAELHAKQTQLT 592
Cdd:PRK01156 515 NKSINEYNKIESARADLE 532
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
32-778 |
9.35e-11 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 66.09 E-value: 9.35e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 32 LINGPTGAGKSSILDAICYAMY-----------GETTGSERTGDQ-MRCDYAEEGLLTEIQ----------------FMF 83
Cdd:COG4913 28 LLTGDNGSGKSTLLDAIQTLLVpakrprfnkaaNDAGKSDRTLLSyVRGKYGSERDEAGTRpvylrpgdtwsaiaatFAN 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 84 QLNGRVFNVTRSPDQEVpkkrgeGTTKKSHSATLCEIVEGE--EKLLANRPSPVA----KAMVDLIGLDV--------KQ 149
Cdd:COG4913 108 DGSGQTVTLAQVFWLKG------DASSLGDVKRFFVIADGPldLEDFEEFAHGFDiralKARLKKQGVEFfdsfsaylAR 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 150 FRQVMVIPQGKFRELL--IANSKereQIFG--QLFQTHIYTqiERTLFERaagIRKEKDEFDNqIKGALDVVsvsseEEL 225
Cdd:COG4913 182 LRRRLGIGSEKALRLLhkTQSFK---PIGDldDFVREYMLE--EPDTFEA---ADALVEHFDD-LERAHEAL-----EDA 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 226 KDEKSKLAPVLKEAEiSYQAAQTSLDTVkQQHGAAIELQQKFAQKEALDKELQLEVAKQSEMDVVRARKQQALQAARlds 305
Cdd:COG4913 248 REQIELLEPIRELAE-RYAAARERLAEL-EYLRAALRLWFAQRRLELLEAELEELRAELARLEAELERLEARLDALR--- 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 306 pfNEMNAAEKQLNQAQsavvarTDAVALATKQVTEADTVYQAAISNCSQLESLTAQLH-QLEATGKKFAALdeqQKQLAA 384
Cdd:COG4913 323 --EELDELEAQIRGNG------GDRLEQLEREIERLERELEERERRRARLEALLAALGlPLPASAEEFAAL---RAEAAA 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 385 ASQLFTSAKHAFQQAesaLQTLDQQIQVKRKEKEAAQLQLATLDSQRSslNIISEHIERRTRLQQLTQQlhDKAQLH--- 461
Cdd:COG4913 392 LLEALEEELEALEEA---LAEAEAALRDLRRELRELEAEIASLERRKS--NIPARLLALRDALAEALGL--DEAELPfvg 464
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 462 -----QQAEQAYKEAQEK------TRL---AKQRADQLEYVWHTNQAAEL----AKLLQEGDACPVCGSHShpqlaqFSG 523
Cdd:COG4913 465 elievRPEEERWRGAIERvlggfaLTLlvpPEHYAAALRWVNRLHLRGRLvyerVRTGLPDPERPRLDPDS------LAG 538
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 524 DVVTKE---------QVQQARDHQQTAAnteTQALKRHE-ALTAEHQ-------HLKQDvelletaikEKRIPE------ 580
Cdd:COG4913 539 KLDFKPhpfrawleaELGRRFDYVCVDS---PEELRRHPrAITRAGQvkgngtrHEKDD---------RRRIRSryvlgf 606
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 581 -----LAELHAKQTQLTTEIARLQALNPAQLEQQLQqlefsfNAAKQTLDNQLAARQTAEIAVAEAQTRVNDLQRDitse 655
Cdd:COG4913 607 dnrakLAALEAELAELEEELAEAEERLEALEAELDA------LQERREALQRLAEYSWDEIDVASAEREIAELEAE---- 676
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 656 fthvdevRQRYSQVQKQIKALTEAEQQARAALNAAQNQLSSAQAALASAQEQHTSWSREVKRAQQQWQQALAETPFADRe 735
Cdd:COG4913 677 -------LERLDASSDDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELR- 748
|
810 820 830 840
....*....|....*....|....*....|....*....|....
gi 2176024252 736 AYLAAKLDDQALAALDEQLRR-FDEGLATLKGKLESLVQSLADK 778
Cdd:COG4913 749 ALLEERFAAALGDAVERELREnLEERIDALRARLNRAEEELERA 792
|
|
| PRK02224 |
PRK02224 |
DNA double-strand break repair Rad50 ATPase; |
33-835 |
5.84e-10 |
|
DNA double-strand break repair Rad50 ATPase;
Pssm-ID: 179385 [Multi-domain] Cd Length: 880 Bit Score: 63.52 E-value: 5.84e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 33 INGPTGAGKSSILDAICYAMYGETTGSERTGDQMRCDyAEEgllTEIQFMFQLNGRVFNVTRSpdqeVPKKRGEGTTKKS 112
Cdd:PRK02224 28 IHGVNGSGKSSLLEACFFALYGSKALDDTLDDVITIG-AEE---AEIELWFEHAGGEYHIERR----VRLSGDRATTAKC 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 113 HSATLCEIVEGeekllANRpspVAKAMVDLIGLDVKQFRQVMVIPQGKFRELLIANSKEREQIFGQLFQ----------- 181
Cdd:PRK02224 100 VLETPEGTIDG-----ARD---VREEVTELLRMDAEAFVNCAYVRQGEVNKLINATPSDRQDMIDDLLQlgkleeyrera 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 182 ------------------THIYTQIE----RTLFERAAGIRKEKDEFDNQIkgaldvvsvsseEELKDEKSKLAPVLKEA 239
Cdd:PRK02224 172 sdarlgvervlsdqrgslDQLKAQIEekeeKDLHERLNGLESELAELDEEI------------ERYEEQREQARETRDEA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 240 EI---SYQAAQTSLDTVKQqhgAAIELQQKFAQKEALDKELQLEVAKQSE-MDVVRARKQQALQAARLDSPfnemnaaek 315
Cdd:PRK02224 240 DEvleEHEERREELETLEA---EIEDLRETIAETEREREELAEEVRDLRErLEELEEERDDLLAEAGLDDA--------- 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 316 qlnqAQSAVVARTDAVALATKQVTEA-DTVYQAAISNCSQLESLTAQLHQLEATGKKfaaLDEQQKQLAAASQlftSAKH 394
Cdd:PRK02224 308 ----DAEAVEARREELEDRDEELRDRlEECRVAAQAHNEEAESLREDADDLEERAEE---LREEAAELESELE---EARE 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 395 AFQQAESALQTLDQQIQVKRKEKEAAQLQLATLDSQRSSLniISEHIERRTRLQQLTQQLhdkaqlhQQAEQAYKEAQEk 474
Cdd:PRK02224 378 AVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEEL--REERDELREREAELEATL-------RTARERVEEAEA- 447
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 475 trlakqradqleyvwhtnqaaelakLLQEGDaCPVCGshshpQLAQFSGDVVT----KEQVQQARDHQQTAANTETQALK 550
Cdd:PRK02224 448 -------------------------LLEAGK-CPECG-----QPVEGSPHVETieedRERVEELEAELEDLEEEVEEVEE 496
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 551 RHEALTA------EHQHLKQDVELLETAIKEKRipelAELHAKQTQLTTEIARLQALNPAQLEQQLQqlefsfnAAKQTL 624
Cdd:PRK02224 497 RLERAEDlveaedRIERLEERREDLEELIAERR----ETIEEKRERAEELRERAAELEAEAEEKREA-------AAEAEE 565
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 625 DNQLAARQTAEI--AVAEAQTRVNDLqRDITSEFTHVDEVRQRYSQVQKQIKALTEAEQQARAALNAaqnqlssaqaala 702
Cdd:PRK02224 566 EAEEAREEVAELnsKLAELKERIESL-ERIRTLLAAIADAEDEIERLREKREALAELNDERRERLAE------------- 631
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 703 saqeqhtswsrevKRaqqqwqqalaetpfaDREAYLAAKLDDQALAALDEQLRRFDEGLATLKGKLESLVQSlADKTLPQ 782
Cdd:PRK02224 632 -------------KR---------------ERKRELEAEFDEARIEEAREDKERAEEYLEQVEEKLDELREE-RDDLQAE 682
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|...
gi 2176024252 783 MENLESALAERQSAvtaafnvlavhRSRMDSLVQVEQKLARLYEKNAELDKAY 835
Cdd:PRK02224 683 IGAVENELEELEEL-----------RERREALENRVEALEALYDEAEELESMY 724
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
223-853 |
6.60e-10 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 63.54 E-value: 6.60e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 223 EELKDEKSKLAPVLKEAEISYQAAQTSLDTVKQQhgaAIELQQKFAQKEALDKELQLEVAkQSEMDVVRARKQQALQAAR 302
Cdd:TIGR02168 270 EELRLEVSELEEEIEELQKELYALANEISRLEQQ---KQILRERLANLERQLEELEAQLE-ELESKLDELAEELAELEEK 345
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 303 LDSPFNEMNAAEKQLNQAQSAVVARTDAVALATKQVTEA----DTVYQAAISNCSQLESLTAQLHQLEATGKKF------ 372
Cdd:TIGR02168 346 LEELKEELESLEAELEELEAELEELESRLEELEEQLETLrskvAQLELQIASLNNEIERLEARLERLEDRRERLqqeiee 425
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 373 -------AALDEQQKQLAAASQLFTSAKHAFQQAESALQTLDQQIQVKRKEKEAAQLQLATLDSQRSSLNIISEHIERRT 445
Cdd:TIGR02168 426 llkkleeAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFS 505
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 446 R-LQQLTQQLHDKAQLHQQAEQAYkEAQEKTRLAKQRA--DQLEYVWHTNQAAelAKLLQEGDACPVCGSHSHPQLAQFS 522
Cdd:TIGR02168 506 EgVKALLKNQSGLSGILGVLSELI-SVDEGYEAAIEAAlgGRLQAVVVENLNA--AKKAIAFLKQNELGRVTFLPLDSIK 582
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 523 G---DVVTKEQVQQARDHQQTAANTETQALKRHEAL-------------------------------------------- 555
Cdd:TIGR02168 583 GteiQGNDREILKNIEGFLGVAKDLVKFDPKLRKALsyllggvlvvddldnalelakklrpgyrivtldgdlvrpggvit 662
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 556 -------------TAEHQHLKQDVELLETAIKEKRIpELAELHAKQTQLTTEIARLQALNPAQLEQQLQQLEfSFNAAKQ 622
Cdd:TIGR02168 663 ggsaktnssilerRREIEELEEKIEELEEKIAELEK-ALAELRKELEELEEELEQLRKELEELSRQISALRK-DLARLEA 740
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 623 TLDNQLAARQTAEIAVAEAQTRVNDLQRDITSEFTHVDEVRQRYSQVQKQIKALTEAEQQARAALNAAQnqlssaqaala 702
Cdd:TIGR02168 741 EVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELR----------- 809
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 703 saqEQHTSWSREVKRAQQQWQQALAEtpfadreaylaaklddqaLAALDEQLRRFDEGLATLKGKLESLVQSLADKTLpQ 782
Cdd:TIGR02168 810 ---AELTLLNEEAANLRERLESLERR------------------IAATERRLEDLEEQIEELSEDIESLAAEIEELEE-L 867
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2176024252 783 MENLESALAERQSAVTAAFNVLAVHRSRMDSLV----QVEQKLARLYEKNAELDKAyqvygtLSDIANGRTGAKV 853
Cdd:TIGR02168 868 IEELESELEALLNERASLEEALALLRSELEELSeelrELESKRSELRRELEELREK------LAQLELRLEGLEV 936
|
|
| SMC_prok_A |
TIGR02169 |
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
5-600 |
1.84e-09 |
|
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 62.01 E-value: 1.84e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 5 KLTLQAFGPFASQEVVDFTElghaPLFLINGPTGAGKSSILDAICYAMYGETTGS---ERTGDQM-RCDYAEEGLLTEIQ 80
Cdd:TIGR02169 4 RIELENFKSFGKKKVIPFSK----GFTVISGPNGSGKSNIGDAILFALGLSSSKAmraERLSDLIsNGKNGQSGNEAYVT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 81 FMFQLNGRVFnvtrsPDQEVPKKRGEGTTKKSHSATLceiVEGEEKLLANRPSPVAKAMVDLIGLDVkqfrqVMvipQGK 160
Cdd:TIGR02169 80 VTFKNDDGKF-----PDELEVVRRLKVTDDGKYSYYY---LNGQRVRLSEIHDFLAAAGIYPEGYNV-----VL---QGD 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 161 FRELLIANSKEReqifgqlfqthiytqieRTLFERAAGIrkekDEFDNQIKGA---LDVVSVSSE------EELKDEKSK 231
Cdd:TIGR02169 144 VTDFISMSPVER-----------------RKIIDEIAGV----AEFDRKKEKAleeLEEVEENIErldliiDEKRQQLER 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 232 LAPVLKEAEiSYQAAQTSLDTvkqqhgaaIELQQKFAQKEALDKELQlevakQSEMDVVRARKQQALQAARLDSPFNEMN 311
Cdd:TIGR02169 203 LRREREKAE-RYQALLKEKRE--------YEGYELLKEKEALERQKE-----AIERQLASLEEELEKLTEEISELEKRLE 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 312 AAEKQLNQAQSAVVARTDAVALATKqvteadtvyqaaisncSQLESLTAQLHQLEatgkkfAALDEQQKQLaaasqlfts 391
Cdd:TIGR02169 269 EIEQLLEELNKKIKDLGEEEQLRVK----------------EKIGELEAEIASLE------RSIAEKEREL--------- 317
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 392 akhafQQAESALQTLDQQIQVKRKEKEAAQLQLATLDSQRSSLniISEHIERRTRLQQLTQQLHDKAQLHQQAEQAYKEA 471
Cdd:TIGR02169 318 -----EDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKL--TEEYAELKEELEDLRAELEEVDKEFAETRDELKDY 390
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 472 QEKTRLAKQRADQLEyvwhtnqaAELAKLLQEgdacpvcGSHSHPQLAQFSGDVVTKEQvqqardhQQTAANTETQALKr 551
Cdd:TIGR02169 391 REKLEKLKREINELK--------RELDRLQEE-------LQRLSEELADLNAAIAGIEA-------KINELEEEKEDKA- 447
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|.
gi 2176024252 552 hEALTAEHQHLKQDVELLETAIKEKR--IPELAELHAKQTQLTTEIARLQA 600
Cdd:TIGR02169 448 -LEIKKQEWKLEQLAADLSKYEQELYdlKEEYDRVEKELSKLQRELAEAEA 497
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
530-831 |
2.18e-08 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 58.53 E-value: 2.18e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 530 QVQQARDHQQTAANTETQALKRHEALTAEHQHLKQDVELLETAIKEKRiPELAELHAKQTQLTTEIARLQAlnpaqleqQ 609
Cdd:TIGR02168 233 RLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELE-EEIEELQKELYALANEISRLEQ--------Q 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 610 LQQLEFSFNAAKQTLDNQLAARQTAEIAVAEAQTRVNDLQRDITSEFTHVDEVRQRYSQVQKQIKALTEAEQQARAALNA 689
Cdd:TIGR02168 304 KQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLET 383
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 690 AQNQLSSAQAALASAQEQHTSWSREVKRAQQQWQQALAETPFADReaylaaKLDDQALAALDEQLRRFDEGLATLKGKLE 769
Cdd:TIGR02168 384 LRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLK------KLEEAELKELQAELEELEEELEELQEELE 457
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2176024252 770 SLVQSLadktlpqmENLESALAERQSAVTAAFNVLAVHRSRMDSLVQVEQKLARLYEKNAEL 831
Cdd:TIGR02168 458 RLEEAL--------EELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKAL 511
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
355-686 |
2.51e-08 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 58.14 E-value: 2.51e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 355 LESLTAQLHQLEAtgkkfaALDEQQKQLAAASQLFTSAKHAFQQAESALQTLDQQI-----QVKRKEKEAAQLQLATLDS 429
Cdd:TIGR02168 679 IEELEEKIEELEE------KIAELEKALAELRKELEELEEELEQLRKELEELSRQIsalrkDLARLEAEVEQLEERIAQL 752
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 430 QRSSLNIISEHIERRTRLQQLTQQLH----DKAQLHQQAEQAYKEAQE-KTRLAKQRAD-QLEYVWHTNQAAELAKLLQE 503
Cdd:TIGR02168 753 SKELTELEAEIEELEERLEEAEEELAeaeaEIEELEAQIEQLKEELKAlREALDELRAElTLLNEEAANLRERLESLERR 832
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 504 GDACPVCGSHSHPQLAQFSGDVvtkEQVQQARDHQQTAANTETQALKRHEALTAEHQH----LKQDVELLETAIK--EKR 577
Cdd:TIGR02168 833 IAATERRLEDLEEQIEELSEDI---ESLAAEIEELEELIEELESELEALLNERASLEEalalLRSELEELSEELRelESK 909
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 578 IPEL-AELHAKQTQLTTEIARLQALNpaqLEQQLQQLEFSfNAAKQTLDNQLAARQTAEIAVAEAQTRVNDLQRDITS-- 654
Cdd:TIGR02168 910 RSELrRELEELREKLAQLELRLEGLE---VRIDNLQERLS-EEYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKElg 985
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 2176024252 655 --------EFthvDEVRQRYSQVQKQIKALTEAEQQARAA 686
Cdd:TIGR02168 986 pvnlaaieEY---EELKERYDFLTAQKEDLTEAKETLEEA 1022
|
|
| mukB |
PRK04863 |
chromosome partition protein MukB; |
238-486 |
2.78e-08 |
|
chromosome partition protein MukB;
Pssm-ID: 235316 [Multi-domain] Cd Length: 1486 Bit Score: 58.04 E-value: 2.78e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 238 EAEISYQAAQTSLDTVKQQ---HGAAIELQQKFA-----QKEALDKELQLEVAKQSEMDVVRARKQQAlqAARLDSPFNE 309
Cdd:PRK04863 380 ENEARAEAAEEEVDELKSQladYQQALDVQQTRAiqyqqAVQALERAKQLCGLPDLTADNAEDWLEEF--QAKEQEATEE 457
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 310 MNAAEKQLNQAQSAVVARTDAVALATKQV--TEADTVYQAAISNCSQLESLTAQLHQLEATGKKFAALDEQQKQLAAASQ 387
Cdd:PRK04863 458 LLSLEQKLSVAQAAHSQFEQAYQLVRKIAgeVSRSEAWDVARELLRRLREQRHLAEQLQQLRMRLSELEQRLRQQQRAER 537
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 388 LFTSAKHAFQQAESALQTLDQQIQVKRKEKEAAQLQLATLDSQRSSLniisehierRTRLQQLTQQLhdkAQLHQQAeQA 467
Cdd:PRK04863 538 LLAEFCKRLGKNLDDEDELEQLQEELEARLESLSESVSEARERRMAL---------RQQLEQLQARI---QRLAARA-PA 604
|
250 260
....*....|....*....|
gi 2176024252 468 YKEAQEK-TRLAKQRADQLE 486
Cdd:PRK04863 605 WLAAQDAlARLREQSGEEFE 624
|
|
| SbcC |
COG0419 |
DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]; |
914-987 |
3.85e-08 |
|
DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair];
Pssm-ID: 440188 [Multi-domain] Cd Length: 204 Bit Score: 54.63 E-value: 3.85e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2176024252 914 DVATLSGGESfmaalsLALGLSDVVQsysggirldtLFIDegFGSLDPESLDLAIQTLIDLQqggrtigIISHV 987
Cdd:COG0419 155 PIETLSGGER------LRLALADLLS----------LILD--FGSLDEERLERLLDALEELA-------IITHV 203
|
|
| SbcC_Walker_B |
pfam13558 |
SbcC/RAD50-like, Walker B motif; This entry represents the Walker B domain of RAD50 from ... |
905-971 |
8.78e-08 |
|
SbcC/RAD50-like, Walker B motif; This entry represents the Walker B domain of RAD50 from eukaryotes and the prokaryotic homolog SbcCD complex subunit C. RAD50-ATPase forms a complex with Mre11-nuclease that detects and processes diverse and obstructed DNA ends. This domain is separated of the Walker A domain by a long coiled-coil domain and forms the nucleotide-binding domain (NBD) when the coiled coils fold back on themselves and bring together Walker A and B domains. Two RAD50-NBDs forms heterotetramers with a Mre11 nuclease dimer that assemble as catalytic head module that binds and cleaves DNA in an ATP-dependent reaction. Through secondary structural analysis, it has been suggested that there is a wide structural conservation in the Rad50/SMC protein family as seen in structural similarities between RAD50's hook and ABC-ATPase MukB's elbow region.
Pssm-ID: 463921 [Multi-domain] Cd Length: 90 Bit Score: 50.70 E-value: 8.78e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 905 EDGYTGKW-RDVATLSGGES-FMAALSLALGLSDVVQSYSG-GIRLDTLFIDEGFGSLDPESLDLAIQTL 971
Cdd:pfam13558 19 EDGSEVETyRRSGGLSGGEKqLLAYLPLAAALAAQYGSAEGrPPAPRLVFLDEAFAKLDEENIRTALELL 88
|
|
| ABC_Class2 |
cd03227 |
ATP-binding cassette domain of non-transporter proteins; ABC-type Class 2 contains systems ... |
5-64 |
2.15e-07 |
|
ATP-binding cassette domain of non-transporter proteins; ABC-type Class 2 contains systems involved in cellular processes other than transport. These families are characterized by the fact that the ABC subunit is made up of duplicated, fused ABC modules (ABC2). No known transmembrane proteins or domains are associated with these proteins.
Pssm-ID: 213194 [Multi-domain] Cd Length: 162 Bit Score: 51.59 E-value: 2.15e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 5 KLTLQAFGPFASQEVVDFtelGHAPLFLINGPTGAGKSSILDAICYAMYGETTGSERTGD 64
Cdd:cd03227 1 KIVLGRFPSYFVPNDVTF---GEGSLTIITGPNGSGKSTILDAIGLALGGAQSATRRRSG 57
|
|
| PRK03918 |
PRK03918 |
DNA double-strand break repair ATPase Rad50; |
32-992 |
3.23e-07 |
|
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 54.68 E-value: 3.23e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 32 LINGPTGAGKSSILDAICYAMYGETtgSERTGDQMRCDYAEEGL-LTEIQFMFQLNGRVFNVTRSPDQEVPKKRGEGTTK 110
Cdd:PRK03918 27 LIIGQNGSGKSSILEAILVGLYWGH--GSKPKGLKKDDFTRIGGsGTEIELKFEKNGRKYRIVRSFNRGESYLKYLDGSE 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 111 KSHSATlceivegeekllanrpSPVAKAMVDLIGLDVkqFRQVMVIPQGKFrELLIANSKEREQIFGQLFQTHIYTQIER 190
Cdd:PRK03918 105 VLEEGD----------------SSVREWVERLIPYHV--FLNAIYIRQGEI-DAILESDESREKVVRQILGLDDYENAYK 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 191 TLFERAAGIRKEKDEFDNQIKGALDVvsvssEEELKDEKSKLAPVLKEAeisyqaaqtsldtvkqqhgaaielqqkfaqK 270
Cdd:PRK03918 166 NLGEVIKEIKRRIERLEKFIKRTENI-----EELIKEKEKELEEVLREI------------------------------N 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 271 EALDKELQLEvakqSEMDVVRARKQqalqaaRLDSPFNEMNAAEKQLNQAQSAVVArtdavalatkqvteadtvYQAAIS 350
Cdd:PRK03918 211 EISSELPELR----EELEKLEKEVK------ELEELKEEIEELEKELESLEGSKRK------------------LEEKIR 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 351 NC-SQLESLTAQLHQLEATGKKFAALDEQQKQLAAASQLFTSAKHAFQQAESALQTLDQQIQ-VKRKEKEAAQL--QLAT 426
Cdd:PRK03918 263 ELeERIEELKKEIEELEEKVKELKELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINgIEERIKELEEKeeRLEE 342
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 427 LDSQRSSLNIISEHIERRTRLQQLTQQLHDKAQLH----------------QQAEQAYKEAQEKTRLAKQRADQLEyvwh 490
Cdd:PRK03918 343 LKKKLKELEKRLEELEERHELYEEAKAKKEELERLkkrltgltpeklekelEELEKAKEEIEEEISKITARIGELK---- 418
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 491 tNQAAELAKLLQE----GDACPVCG-----SHSHPQLAQFSGDVVT-----KEQVQQARDHQQTAANTETqALKRHEALT 556
Cdd:PRK03918 419 -KEIKELKKAIEElkkaKGKCPVCGrelteEHRKELLEEYTAELKRiekelKEIEEKERKLRKELRELEK-VLKKESELI 496
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 557 AEHQHLKQ-----------DVELLETAIK--EKRIPELAELHAKQTQLTTEIARLQALNpaqleqqlqqlefsfnaakqt 623
Cdd:PRK03918 497 KLKELAEQlkeleeklkkyNLEELEKKAEeyEKLKEKLIKLKGEIKSLKKELEKLEELK--------------------- 555
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 624 ldNQLAArqtAEIAVAEAQTRVNDLQRDITSE-FTHVDEVRQRYSQVQKQIK---ALTEAEQQARAALNAAQNQLSSAQA 699
Cdd:PRK03918 556 --KKLAE---LEKKLDELEEELAELLKELEELgFESVEELEERLKELEPFYNeylELKDAEKELEREEKELKKLEEELDK 630
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 700 ALASAQEQHTSWSREVKRAQQQWQQALAETPFADREAYLaaklddqalaALDEQLRRFDEGLATLKGKLESLVQSLadkt 779
Cdd:PRK03918 631 AFEELAETEKRLEELRKELEELEKKYSEEEYEELREEYL----------ELSRELAGLRAELEELEKRREEIKKTL---- 696
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 780 lpqmENLESALAERQSAvtaafnvlavhRSRMDSLVQVEQKLARLYEKNAELdKAYQVYGTLSDIANgrtgakvslhrfv 859
Cdd:PRK03918 697 ----EKLKEELEEREKA-----------KKELEKLEKALERVEELREKVKKY-KALLKERALSKVGE------------- 747
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 860 lgvllddvliQASQRLQMMSKGRY---LLKRKEERAKgnagsgldLMVEdgYTGKWRDVATLSGGESFMAALSLALGLSd 936
Cdd:PRK03918 748 ----------IASEIFEELTEGKYsgvRVKAEENKVK--------LFVV--YQGKERPLTFLSGGERIALGLAFRLALS- 806
|
970 980 990 1000 1010 1020
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 937 vvqSYSGGiRLDTLFIDEGFGSLDPESLdlaiQTLID-LQQGGRTIG---IISHVTELKE 992
Cdd:PRK03918 807 ---LYLAG-NIPLLILDEPTPFLDEERR----RKLVDiMERYLRKIPqviIVSHDEELKD 858
|
|
| SMC_N |
pfam02463 |
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ... |
5-489 |
4.69e-07 |
|
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.
Pssm-ID: 426784 [Multi-domain] Cd Length: 1161 Bit Score: 54.21 E-value: 4.69e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 5 KLTLQAFGPFASQEVVDFTELGHAplflINGPTGAGKSSILDAICYAMygettgSERTGDQMRCDYAEeGLLTEIQFMFQ 84
Cdd:pfam02463 4 RIEIEGFKSYAKTVILPFSPGFTA----IVGPNGSGKSNILDAILFVL------GERSAKSLRSERLS-DLIHSKSGAFV 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 85 LNGRVFNVTRSPDQEVPKKRGEGTTKKShsatlcEIVEGEEKLLANRPSPVAKAMVDL---IGLDVKQFRqvMVIPQGKF 161
Cdd:pfam02463 73 NSAEVEITFDNEDHELPIDKEEVSIRRR------VYRGGDSEYYINGKNVTKKEVAELlesQGISPEAYN--FLVQGGKI 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 162 RELLIANSKEREQIFGQLFQTHIYTQIERTL--FERAAGIRKEKDEFDNQIKGALDVVSVSSEEELKDEKSKLAPVLKEA 239
Cdd:pfam02463 145 EIIAMMKPERRLEIEEEAAGSRLKRKKKEALkkLIEETENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEE 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 240 EISYQAAQTSLDTVKQQHGAAIELQQKFAQKEALDKELQLEVAKQSEMDVVRARKQQALQAARLDSPFNEMNAAEKQLNQ 319
Cdd:pfam02463 225 YLLYLDYLKLNEERIDLLQELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLK 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 320 AQSAVVARTDAVALATKQVTEADTVYQAAISNCSQLESL--TAQLHQLEATGKKFAALDEQQKQLAAASQLFTSAKHAFQ 397
Cdd:pfam02463 305 LERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKElkELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESE 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 398 QAESALQTLDQQIQVKRKEKEAAQLQLATLDSQRSSLNIISEHIERRTRLQQLTQqlhDKAQLHQQAEQAYKEAQEKTRL 477
Cdd:pfam02463 385 RLSSAAKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESI---ELKQGKLTEEKEELEKQELKLL 461
|
490
....*....|..
gi 2176024252 478 AKQRADQLEYVW 489
Cdd:pfam02463 462 KDELELKKSEDL 473
|
|
| ABC_ATPase |
cd00267 |
ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large ... |
918-998 |
2.98e-06 |
|
ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide-binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.
Pssm-ID: 213179 [Multi-domain] Cd Length: 157 Bit Score: 48.01 E-value: 2.98e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 918 LSGGESFMAALSLALGLSDvvqsysggirlDTLFIDEGFGSLDPESLDLAIQTLIDLQQGGRTIGIISHVTELKEQISLR 997
Cdd:cd00267 81 LSGGQRQRVALARALLLNP-----------DLLLLDEPTSGLDPASRERLLELLRELAEEGRTVIIVTHDPELAELAADR 149
|
.
gi 2176024252 998 L 998
Cdd:cd00267 150 V 150
|
|
| 46 |
PHA02562 |
endonuclease subunit; Provisional |
32-457 |
3.03e-06 |
|
endonuclease subunit; Provisional
Pssm-ID: 222878 [Multi-domain] Cd Length: 562 Bit Score: 51.17 E-value: 3.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 32 LINGPTGAGKSSILDAICYAMYGETTGSERTGdQMRCDYAEEGLLTEIQfmFQLNGRVFNVTRSPDQEVpkkrgegttkk 111
Cdd:PHA02562 31 LITGKNGAGKSTMLEALTFALFGKPFRDIKKG-QLINSINKKDLLVELW--FEYGEKEYYIKRGIKPNV----------- 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 112 shsatlCEIVEGEEKLLANRPSPVAKAMVD-LIGLDVKQFRQVMVIPQGKFREllianskereqiFGQLfqthiytqier 190
Cdd:PHA02562 97 ------FEIYCNGKLLDESASSKDFQKYFEqMLGMNYKSFKQIVVLGTAGYVP------------FMQL----------- 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 191 tlfeRAAGIRK-EKDEFDNQIKGALDVVSVSSEEELKDEKSKLapvlkeaeiSYQaaqtsLDTVKQQhgaaIELQQKF-- 267
Cdd:PHA02562 148 ----SAPARRKlVEDLLDISVLSEMDKLNKDKIRELNQQIQTL---------DMK-----IDHIQQQ----IKTYNKNie 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 268 ----AQKEALDkELQ------LEVAKQSEMDVVRARKqqalQAARLDSPFNEMNAAEKQLNQAQSAVVARTDAVALATKQ 337
Cdd:PHA02562 206 eqrkKNGENIA-RKQnkydelVEEAKTIKAEIEELTD----ELLNLVMDIEDPSAALNKLNTAAAKIKSKIEQFQKVIKM 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 338 VTEAD---TVYQAAISNCSQLESLTAQLHQLEatgKKFAALDEQQKQLAAASQLFTSAKHAFQQAESALQTLDQQI---- 410
Cdd:PHA02562 281 YEKGGvcpTCTQQISEGPDRITKIKDKLKELQ---HSLEKLDTAIDELEEIMDEFNEQSKKLLELKNKISTNKQSLitlv 357
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 2176024252 411 -QVKRKEKEAAQLQlatldsqrsslniiSEHIERRTRLQQLTQQLHDK 457
Cdd:PHA02562 358 dKAKKVKAAIEELQ--------------AEFVDNAEELAKLQDELDKI 391
|
|
| ABC_Class2 |
cd03227 |
ATP-binding cassette domain of non-transporter proteins; ABC-type Class 2 contains systems ... |
918-992 |
3.50e-06 |
|
ATP-binding cassette domain of non-transporter proteins; ABC-type Class 2 contains systems involved in cellular processes other than transport. These families are characterized by the fact that the ABC subunit is made up of duplicated, fused ABC modules (ABC2). No known transmembrane proteins or domains are associated with these proteins.
Pssm-ID: 213194 [Multi-domain] Cd Length: 162 Bit Score: 48.12 E-value: 3.50e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2176024252 918 LSGGESFMAALSLALGLSDVvqsysggIRLDTLFIDEGFGSLDPESLDLAIQTLIDLQQGGRTIGIISHVTELKE 992
Cdd:cd03227 78 LSGGEKELSALALILALASL-------KPRPLYILDEIDRGLDPRDGQALAEAILEHLVKGAQVIVITHLPELAE 145
|
|
| PRK11281 |
PRK11281 |
mechanosensitive channel MscK; |
330-603 |
1.46e-05 |
|
mechanosensitive channel MscK;
Pssm-ID: 236892 [Multi-domain] Cd Length: 1113 Bit Score: 49.14 E-value: 1.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 330 AVALATKQVTEADTvyQAAISNCSQLESLTAQ----LHQLEATGKKFAALDEQQKQLAAASQLFTSAKHAFQQAESALQT 405
Cdd:PRK11281 28 RAASNGDLPTEADV--QAQLDALNKQKLLEAEdklvQQDLEQTLALLDKIDRQKEETEQLKQQLAQAPAKLRQAQAELEA 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 406 L-DQQIQVKRKEKEA-------------------AQLQLATLDSQRSSLNIISEHI-----ERRTRLQQLTQQLHDkaql 460
Cdd:PRK11281 106 LkDDNDEETRETLSTlslrqlesrlaqtldqlqnAQNDLAEYNSQLVSLQTQPERAqaalyANSQRLQQIRNLLKG---- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 461 hQQAEQAYKEAQEKTRLAkqradqleyvwhtnqaAELAKLLQegdacpvcgshshpqlaqfsgdvvtkeQVQQARdhQQT 540
Cdd:PRK11281 182 -GKVGGKALRPSQRVLLQ----------------AEQALLNA---------------------------QNDLQR--KSL 215
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2176024252 541 AANTETQAL--KRHEALTAEHQHLKQDVELLETAIKEKRIpELAELHAKQTQLTTEIARLQAlNP 603
Cdd:PRK11281 216 EGNTQLQDLlqKQRDYLTARIQRLEHQLQLLQEAINSKRL-TLSEKTVQEAQSQDEAARIQA-NP 278
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
278-486 |
1.62e-05 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 48.22 E-value: 1.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 278 QLEVAKQSEMDVVRARKQQALQAARLDSPFNEMNAAEKQLNQAQSAVVARTDAVALATKQVTEADTVYQAAIsncSQLES 357
Cdd:COG4942 18 QADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELE---KEIAE 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 358 LTAQLHQLEATGKKFAALDEQQKQLAAASQLFTSAkhAFQQAESALQTLDQQIQVKRKEKEAAQLQLATLDSQRSSLNII 437
Cdd:COG4942 95 LRAELEAQKEELAELLRALYRLGRQPPLALLLSPE--DFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAE 172
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 2176024252 438 SEHI-----ERRTRLQQLTQQLHDKAQLHQQAEQAYKEAQEKTRLAKQRADQLE 486
Cdd:COG4942 173 RAELeallaELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELE 226
|
|
| AAA_27 |
pfam13514 |
AAA domain; This domain is found in a number of double-strand DNA break proteins. This domain ... |
1-48 |
9.26e-05 |
|
AAA domain; This domain is found in a number of double-strand DNA break proteins. This domain contains a P-loop motif.
Pssm-ID: 433272 [Multi-domain] Cd Length: 207 Bit Score: 44.85 E-value: 9.26e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 2176024252 1 MRPIKLTLQAFGPFASQeVVDFTELGHApLFLINGPTGAGKSSILDAI 48
Cdd:pfam13514 1 MRIRRLDLERYGPFTDR-SLDFPAGGPD-LHLIYGPNEAGKSTALRAI 46
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
382-690 |
1.02e-04 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 45.91 E-value: 1.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 382 LAAASQLFTSAKHAFQQAESALQTLDQQIQVKRKEKEAAQLQLATLDSQrsslniisehierrtrLQQLTQQLHDKAQLH 461
Cdd:COG4942 8 ALLLALAAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQ----------------LAALERRIAALARRI 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 462 QQAEQAYKEAQEKTRLAKQRADQLEYVWHTNQaAELAKLLQegdACPVCGSHSHPQLAQFSGDVvtkeqvqqardhqqta 541
Cdd:COG4942 72 RALEQELAALEAELAELEKEIAELRAELEAQK-EELAELLR---ALYRLGRQPPLALLLSPEDF---------------- 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 542 anteTQALKRHEALTAEHQHLKQDVELLETaikekripELAELHAKQTQLTTEIARLQALnpaqleqqlqqlefsfnaak 621
Cdd:COG4942 132 ----LDAVRRLQYLKYLAPARREQAEELRA--------DLAELAALRAELEAERAELEAL-------------------- 179
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2176024252 622 qtLDNQLAARQTAEIAVAEAQTRVNDLQRDITSEFTHVDEVRQRYSQVQKQIKALTEAEQQARAALNAA 690
Cdd:COG4942 180 --LAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAA 246
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
222-604 |
1.07e-04 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 46.47 E-value: 1.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 222 EEELKDEKSKLAPVLKEAEISYQAAQTSLDTVKQQHGAAIELQQKFAQKEALDKELQLEVAKQSEMDVVRARKQQALQAA 301
Cdd:COG1196 420 EEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEA 499
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 302 RLDSPFNEMNAAEKQLNQAQSAVVARTDAVALATKQVTEADTVYQAAISNCSQLESL-TAQLHQLEATGKKFAALDEQQK 380
Cdd:COG1196 500 EADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDeVAAAAIEYLKAAKAGRATFLPL 579
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 381 QLAAASQLFTSAKHAFQQAESALQTLDQQIQVKRKEKEAAQLQLATLDSQRSSLNIISEHIERRTRLQQLTQQLHDKAQL 460
Cdd:COG1196 580 DKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAG 659
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 461 HQQAEQAYKEAQEKTRLAKQRADQLEyvwhtNQAAELAKLLQEgdacpvcgshshpQLAQFSGDVVTKEQVQQARDHQQT 540
Cdd:COG1196 660 GSLTGGSRRELLAALLEAEAELEELA-----ERLAEEELELEE-------------ALLAEEEEERELAEAEEERLEEEL 721
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2176024252 541 AANTETQALKRHEALTAEHQHLKQDVELLETAIKEKRIPELAELHAKQTQLTTEIARLQALNPA 604
Cdd:COG1196 722 EEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIEALGPVNLL 785
|
|
| Surf_Exclu_PgrA |
TIGR04320 |
SEC10/PgrA surface exclusion domain; This model describes a conserved domain found in surface ... |
303-415 |
1.38e-04 |
|
SEC10/PgrA surface exclusion domain; This model describes a conserved domain found in surface proteins of a number of Firmutes. Many members have LPXTG C-terminal anchoring motifs and a substantial number have the KxYKxGKxW putative sorting signal at the N-terminus. The tetracycline resistance plasmid pCF10 in Enterococcus faecalis promotes conjugal plasmid transfer in response to sex pheromones, but PgrA/Sec10 encoded by that plasmid, a member of this family, specifically inhibits the ability of cells to receive homologous plasmids. The phenomenon is called surface exclusion.
Pssm-ID: 275124 [Multi-domain] Cd Length: 356 Bit Score: 45.49 E-value: 1.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 303 LDSPFNEMNAAEKQLNQAQSAVVARTDAVALATKQVTEADTVYQAAISNcsqLESLTAQLHQLEATgkkfaALDEQQKQL 382
Cdd:TIGR04320 249 IPNPPNSLAALQAKLATAQADLAAAQTALNTAQAALTSAQTAYAAAQAA---LATAQKELANAQAQ-----ALQTAQNNL 320
|
90 100 110
....*....|....*....|....*....|...
gi 2176024252 383 AAASQLFTSAKHAFQQAESALQTLDQQIQVKRK 415
Cdd:TIGR04320 321 ATAQAALANAEARLAKAKEALANLNADLAKKQA 353
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
222-685 |
1.42e-04 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 46.29 E-value: 1.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 222 EEELKDEKSKLAPVLKEAEISYQAAQTSldtvKQQHGAAIELQQKFAQKEALDKELQLEVAKQSEMDVVRARKQQALQAA 301
Cdd:PTZ00121 1179 EAARKAEEVRKAEELRKAEDARKAEAAR----KAEEERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERNNEEI 1254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 302 RLDSPFNEMNAAEKQlnQAQSAVVARTDAVALATKQVTEADTVYQAA-ISNCSQLESLTAQLHQLEATGKKfaaLDEQQK 380
Cdd:PTZ00121 1255 RKFEEARMAHFARRQ--AAIKAEEARKADELKKAEEKKKADEAKKAEeKKKADEAKKKAEEAKKADEAKKK---AEEAKK 1329
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 381 QLAAASQLFTSAKHAFQQAESALQTLDQQIQVKRKEKEAAQLQLATLDSQRSSLNIISEHIERRTRLQQLTQQLHDKAQL 460
Cdd:PTZ00121 1330 KADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADE 1409
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 461 HQQAEQAYKEAQEKTRLA--KQRADQLEYVWHTNQAAELAKLLQEgDACPVCGSHSHPQLAQFSGDVvtKEQVQQARDHQ 538
Cdd:PTZ00121 1410 LKKAAAAKKKADEAKKKAeeKKKADEAKKKAEEAKKADEAKKKAE-EAKKAEEAKKKAEEAKKADEA--KKKAEEAKKAD 1486
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 539 QTAANTETQALKRHEALTAEHQhlKQDVELLETAIKEKRIPEL--AELHAKQTQL--TTEIARLQALNPAQLEQQLQQLE 614
Cdd:PTZ00121 1487 EAKKKAEEAKKKADEAKKAAEA--KKKADEAKKAEEAKKADEAkkAEEAKKADEAkkAEEKKKADELKKAEELKKAEEKK 1564
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2176024252 615 FSFNAAKQTLDNQLAARQtAEIAVAEAQTRVNDLQRditsefTHVDEVRQRYSQVQKQIKALTEAEQQARA 685
Cdd:PTZ00121 1565 KAEEAKKAEEDKNMALRK-AEEAKKAEEARIEEVMK------LYEEEKKMKAEEAKKAEEAKIKAEELKKA 1628
|
|
| ABC_SMC_head |
cd03239 |
The SMC head domain belongs to the ATP-binding cassette superfamily; The structural ... |
5-64 |
2.05e-04 |
|
The SMC head domain belongs to the ATP-binding cassette superfamily; The structural maintenance of chromosomes (SMC) proteins are essential for successful chromosome transmission during replication and segregation of the genome in all organisms. SMCs are generally present as single proteins in bacteria, and as at least six distinct proteins in eukaryotes. The proteins range in size from approximately 110 to 170 kDa, and each has five distinct domains: amino- and carboxy-terminal globular domains, which contain sequences characteristic of ATPases, two coiled-coil regions separating the terminal domains , and a central flexible hinge. SMC proteins function together with other proteins in a range of chromosomal transactions, including chromosome condensation, sister-chromatid cohesion, recombination, DNA repair, and epigenetic silencing of gene expression.
Pssm-ID: 213206 [Multi-domain] Cd Length: 178 Bit Score: 43.07 E-value: 2.05e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 5 KLTLQAFGPFASQEVVDFTElghaPLFLINGPTGAGKSSILDAICYAMyGETTGSERTGD 64
Cdd:cd03239 3 QITLKNFKSYRDETVVGGSN----SFNAIVGPNGSGKSNIVDAICFVL-GGKAAKLRRGS 57
|
|
| GumC |
COG3206 |
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis]; |
261-484 |
2.71e-04 |
|
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442439 [Multi-domain] Cd Length: 687 Bit Score: 45.01 E-value: 2.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 261 IELQQKFAQKEALDKELQLEVAKQSEMDVVRARKQQALQaarldspfNEMNAAEKQLNQAQSAVVARTDAVALATKQVTE 340
Cdd:COG3206 180 LEEQLPELRKELEEAEAALEEFRQKNGLVDLSEEAKLLL--------QQLSELESQLAEARAELAEAEARLAALRAQLGS 251
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 341 ADTVYQAAISNcSQLESLTAQLHQLEAtgkkfaaldeqqkQLAAASQLFTSAKHAFQQAESALQTLDQQIQVKRKE-KEA 419
Cdd:COG3206 252 GPDALPELLQS-PVIQQLRAQLAELEA-------------ELAELSARYTPNHPDVIALRAQIAALRAQLQQEAQRiLAS 317
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2176024252 420 AQLQLATLDSQRSSLN-IISEHIERRTRLQQLTQQLHDKAQLHQQAEQAYKEAQEKTRLAKQRADQ 484
Cdd:COG3206 318 LEAELEALQAREASLQaQLAQLEARLAELPELEAELRRLEREVEVARELYESLLQRLEEARLAEAL 383
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
358-600 |
3.61e-04 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 43.98 E-value: 3.61e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 358 LTAQLHQLEATGKKFAALDEQQKQLAAASQLFTSAKHAFQQAESALQTLDQQIQVKRKEKEAAQLQLATLDSQRSSLnii 437
Cdd:COG4942 12 ALAAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAEL--- 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 438 sehierRTRLQQLTQQLHD-KAQLHQQAEQAYKEAqektrlakqRADQLEYVWHTNQAAELAKLLQegdacpVCGSHSHP 516
Cdd:COG4942 89 ------EKEIAELRAELEAqKEELAELLRALYRLG---------RQPPLALLLSPEDFLDAVRRLQ------YLKYLAPA 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 517 QLAQFSGDVVTKEQVQQARDHQQTAANTETQALKRHEALTAEHQHLKQDVELLETAIKEKRIP---ELAELHAKQTQLTT 593
Cdd:COG4942 148 RREQAEELRADLAELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAElaaELAELQQEAEELEA 227
|
....*..
gi 2176024252 594 EIARLQA 600
Cdd:COG4942 228 LIARLEA 234
|
|
| AAA_29 |
pfam13555 |
P-loop containing region of AAA domain; |
16-56 |
6.74e-04 |
|
P-loop containing region of AAA domain;
Pssm-ID: 433304 [Multi-domain] Cd Length: 61 Bit Score: 38.74 E-value: 6.74e-04
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 2176024252 16 SQEVVDFTELGHaplFLINGPTGAGKSSILDAICYAMYGET 56
Cdd:pfam13555 13 DGHTIPIDPRGN---TLLTGPSGSGKSTLLDAIQTLLVPAK 50
|
|
| PRK10929 |
PRK10929 |
putative mechanosensitive channel protein; Provisional |
222-598 |
6.74e-04 |
|
putative mechanosensitive channel protein; Provisional
Pssm-ID: 236798 [Multi-domain] Cd Length: 1109 Bit Score: 43.89 E-value: 6.74e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 222 EEELKDEKSKLAPVLKEAEISYQAAQTSLDTVKQQHGAAIELQQKFAQKEALDKELQLEVAKQSEMD-------VVRARK 294
Cdd:PRK10929 29 TQELEQAKAAKTPAQAEIVEALQSALNWLEERKGSLERAKQYQQVIDNFPKLSAELRQQLNNERDEPrsvppnmSTDALE 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 295 QQALQAArldspfNEMNAAEKQLNQAQSAVVARTDAVALATKQVTEADtvyqaaisncSQLESLTAQLHQLEATGKKFAa 374
Cdd:PRK10929 109 QEILQVS------SQLLEKSRQAQQEQDRAREISDSLSQLPQQQTEAR----------RQLNEIERRLQTLGTPNTPLA- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 375 ldeqQKQLAAAsqlftsakhafqQAESALQtldqqiQVKRKEKEAAQL------QLATLdsqRSSLniiseHIERRTRLQ 448
Cdd:PRK10929 172 ----QAQLTAL------------QAESAAL------KALVDELELAQLsannrqELARL---RSEL-----AKKRSQQLD 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 449 QLTQQLhdKAQLHQQAEQAYKEAQEKTR-LAKQRADQLEYV---WHTNQaaELAKLLQegdacpvcgshshpQLAQfSGD 524
Cdd:PRK10929 222 AYLQAL--RNQLNSQRQREAERALESTElLAEQSGDLPKSIvaqFKINR--ELSQALN--------------QQAQ-RMD 282
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2176024252 525 VVTKEQVQQARDHQQTaanteTQALKrheALTAEHQHLKQDVELLETAIKE-KRIPELaelhAKQTQLTTEIARL 598
Cdd:PRK10929 283 LIASQQRQAASQTLQV-----RQALN---TLREQSQWLGVSNALGEALRAQvARLPEM----PKPQQLDTEMAQL 345
|
|
| ABC_SMC_barmotin |
cd03278 |
ATP-binding cassette domain of barmotin, a member of the SMC protein family; Barmotin is a ... |
5-66 |
7.75e-04 |
|
ATP-binding cassette domain of barmotin, a member of the SMC protein family; Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (approximately 110 to 170 kDa), and each is arranged into five recognizable domains. Amino-acid sequence homology of SMC proteins between species is largely confined to the amino- and carboxy-terminal globular domains. The amino-terminal domain contains a 'Walker A' nucleotide-binding domain (GxxGxGKS/T, in the single-letter amino-acid code), which by mutational studies has been shown to be essential in several proteins. The carboxy-terminal domain contains a sequence (the DA-box) that resembles a 'Walker B' motif, and a motif with homology to the signature sequence of the ATP-binding cassette (ABC) family of ATPases. The sequence homology within the carboxy-terminal domain is relatively high within the SMC1-SMC4 group, whereas SMC5 and SMC6 show some divergence in both of these sequences. In eukaryotic cells, the proteins are found as heterodimers of SMC1 paired with SMC3, SMC2 with SMC4, and SMC5 with SMC6 (formerly known as Rad18).
Pssm-ID: 213245 [Multi-domain] Cd Length: 197 Bit Score: 41.68 E-value: 7.75e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2176024252 5 KLTLQAFGPFASQEVVDFTElghaPLFLINGPTGAGKSSILDAICYAMyGETTGSERTGDQM 66
Cdd:cd03278 3 KLELKGFKSFADKTTIPFPP----GLTAIVGPNGSGKSNIIDAIRWVL-GEQSAKSLRGEKM 59
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
550-836 |
8.54e-04 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 43.39 E-value: 8.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 550 KRHEALTAEHQHLKQDVELLEtaikekripeLAELHAKQTQLTTEIARLQAlnpaqleqQLQQLEFSFNAAKQTLDNQLA 629
Cdd:COG1196 213 ERYRELKEELKELEAELLLLK----------LRELEAELEELEAELEELEA--------ELEELEAELAELEAELEELRL 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 630 ARQTAEIAVAEAQ-------TRVNDLQRDITSEFTHVDEVRQRYSQVQKQIKALTEAEQQARAALNAAQNQLSSAQAALA 702
Cdd:COG1196 275 ELEELELELEEAQaeeyellAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELE 354
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 703 SAQEQHTSWSREVKRAQQQWQQALAETpFADREAYLAAKLDDQALAALDEQLRRFDEGLATLKGKLESLVQSLADKTLPQ 782
Cdd:COG1196 355 EAEAELAEAEEALLEAEAELAEAEEEL-EELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAEL 433
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 2176024252 783 MENLESALAERQSAVTAAFNVLAVHRSRMDSLVQVEQKLARLYEKNAELDKAYQ 836
Cdd:COG1196 434 EEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELA 487
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
223-473 |
8.84e-04 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 43.37 E-value: 8.84e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 223 EELKDEKSKLAPVLKEAEISYQAAQTSLDTVKQQHGAAIELQQKF--------AQKEALDKELQLEVAKQSEMDVVRARK 294
Cdd:COG4913 613 AALEAELAELEEELAEAEERLEALEAELDALQERREALQRLAEYSwdeidvasAEREIAELEAELERLDASSDDLAALEE 692
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 295 QqaLQAARldspfNEMNAAEKQLNQAQSAVVARTDAVALATKQVTEADTVYQAAISNCSQ-----LESLTAQLHQLEATG 369
Cdd:COG4913 693 Q--LEELE-----AELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLelralLEERFAAALGDAVER 765
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 370 KKFAALDEQQKQLAA----ASQLFTSAKHAFQQA-ESALQTLDQQIqvkrkekEAAQLQLATLDSQRSslNIISEHIER- 443
Cdd:COG4913 766 ELRENLEERIDALRArlnrAEEELERAMRAFNREwPAETADLDADL-------ESLPEYLALLDRLEE--DGLPEYEERf 836
|
250 260 270
....*....|....*....|....*....|
gi 2176024252 444 RTRLQQLTQQlhDKAQLHQQAEQAYKEAQE 473
Cdd:COG4913 837 KELLNENSIE--FVADLLSKLRRAIREIKE 864
|
|
| MARTX_Nterm |
NF012221 |
MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model ... |
253-572 |
1.55e-03 |
|
MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model describes the N-terminal 1900 amino acids of MARTX family multifunctional-autoprocessing repeats-in-toxin holotoxins, which contain both repeat regions that facilitate their entry into eukaryotic target cells, and multiple effector domains.
Pssm-ID: 467957 [Multi-domain] Cd Length: 1848 Bit Score: 42.51 E-value: 1.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 253 VKQQHGAAIE-LQQKFAQKEAL-DKElqlevakQSEMDVVRARKQQALQAArldspfnEMNAAEKQLNQaqsavvarTDA 330
Cdd:NF012221 1540 SSQQADAVSKhAKQDDAAQNALaDKE-------RAEADRQRLEQEKQQQLA-------AISGSQSQLES--------TDQ 1597
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 331 VALATKQVTEADTVYQAAISNCSQLESLTAQLHQLEATGKKFAALDEQQKQLAAA-------SQLFTSAKHAFQQAESAL 403
Cdd:NF012221 1598 NALETNGQAQRDAILEESRAVTKELTTLAQGLDALDSQATYAGESGDQWRNPFAGglldrvqEQLDDAKKISGKQLADAK 1677
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 404 QTL-DQQIQVKR--KEKEAAQLQlatldSQRSSLNIISEHIERRTRLQQLTQQLHDKaqlHQQAEQAYKEAQEKTRLAKQ 480
Cdd:NF012221 1678 QRHvDNQQKVKDavAKSEAGVAQ-----GEQNQANAEQDIDDAKADAEKRKDDALAK---QNEAQQAESDANAAANDAQS 1749
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 481 RADQLEYVWH--TNQAAELAKLLQ--EGDACPVCGSHShpqlAQFSGDVVTKEQVQQARDHQQTAANTETQAlKRHEALT 556
Cdd:NF012221 1750 RGEQDASAAEnkANQAQADAKGAKqdESDKPNRQGAAG----SGLSGKAYSVEGVAEPGSHINPDSPAAADG-RFSEGLT 1824
|
330
....*....|....*.
gi 2176024252 557 AehqhlkQDVELLETA 572
Cdd:NF012221 1825 E------QEQEALEGA 1834
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
157-598 |
1.77e-03 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 42.06 E-value: 1.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 157 PQGKFRELLIANSKEREQIFGQLFQTH-IYTQIERTL------FERAAGIRKEKDEFDNQIKGALDVVSVSSE-EELKDE 228
Cdd:COG4717 61 PQGRKPELNLKELKELEEELKEAEEKEeEYAELQEELeeleeeLEELEAELEELREELEKLEKLLQLLPLYQElEALEAE 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 229 KSKLAPVLKEAEISYQAAQTSLDTVKQQHGAAIELQQKFAQKEALDKELQLEVAKQSEMDVVRARKQQALQAARLDSPFN 308
Cdd:COG4717 141 LAELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQE 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 309 EMNAAEKQLNQAQSAVVARTDAvalatKQVTEADTVYQAAisncSQLESLTAQLHQLEATGKKFAALdeqqkqLAAASQL 388
Cdd:COG4717 221 ELEELEEELEQLENELEAAALE-----ERLKEARLLLLIA----AALLALLGLGGSLLSLILTIAGV------LFLVLGL 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 389 FTSAKHAFQQAESALQTLDQQIQVKRKEKEAAQLQLATLDSQRSSLNIISEHI--ERRTRLQQLTQQLHDKAQLHQQAEQ 466
Cdd:COG4717 286 LALLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEEllELLDRIEELQELLREAEELEEELQL 365
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 467 AYKEAQEKTRLAKQRADQLE-YVWHTNQAAELAKLLQEGDacpvcgsHSHPQLAQFSGDVVTKEQVQQARDHQQTAANTE 545
Cdd:COG4717 366 EELEQEIAALLAEAGVEDEEeLRAALEQAEEYQELKEELE-------ELEEQLEELLGELEELLEALDEEELEEELEELE 438
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 2176024252 546 TQAL---KRHEALTAEHQHLKQDVELLETAikekriPELAELHAKQTQLTTEIARL 598
Cdd:COG4717 439 EELEeleEELEELREELAELEAELEQLEED------GELAELLQELEELKAELREL 488
|
|
| COG4995 |
COG4995 |
Uncharacterized conserved protein, contains CHAT domain [Function unknown]; |
373-821 |
1.91e-03 |
|
Uncharacterized conserved protein, contains CHAT domain [Function unknown];
Pssm-ID: 444019 [Multi-domain] Cd Length: 711 Bit Score: 42.26 E-value: 1.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 373 AALDEQQKQLAAASQLFTSAKHAFQQAESALQTLDQQIQVKRKEKEAAQLQLATLDSQRSSLNIISEHIERRTRLQQLTQ 452
Cdd:COG4995 7 LALLAALLAALALALLALALLLLLAALAAAALLLLALLALLLALAAAAAAALAAAALALALLAAAALALLLLALALAALA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 453 QLHDKAQLHQQAEQAYKEAQEKTRLAKQRADQLEYVWHTNQAAELAKLLQEGDACPVCGSHSHPQLAQFSGDVVTKEQVQ 532
Cdd:COG4995 87 LALLAAALALALAAAALAALALLAALLALAAAAALLALLAALALLALLAALAAALAAAAAAALAAALAAAAAAAAAAALL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 533 QARDHQQTAANTETQALKRHEALTAEHQHLKQDVELLETAIKEKRIPELAELHAKQTQLTTEIARLQALNPAQLEQQLQQ 612
Cdd:COG4995 167 ALALALAAAALALLALLLAALAAALAAAAAALALLLALLLLAALAAALAAALAALLLALLALAAALLALLLLALLALAAA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 613 LEFSFNAAKQTLDNQLAARQTAEIAVAEAQTRVNDLQRDITSEFTHVDEVRQRYSQVQKQIKALTEAEQQARAALNAAQN 692
Cdd:COG4995 247 AAALAAAAAALLALAAALLLLAALAALAAAAAAAALAALALAAALALAAAALALALLLAAAAAAALAALALLLLAALLLL 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 693 QLSSAQAALASAQEQHTSWSREVKRAQQQWQQALAETPFADREAYLAAKLDDQALAALDEQLRRFDEGLATLKGKLESLV 772
Cdd:COG4995 327 LAALALLALLLLLAAAALLAAALAAALALAAALALALLAALLLLLAALLALLLEALLLLLLALLAALLLLAAALLALAAA 406
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 2176024252 773 QSLADKTLPQMENLESALAERQSAVTAAFNVLAVHRSRMDSLVQVEQKL 821
Cdd:COG4995 407 QLLRLLLAALALLLALAAYAAARLALLALIEYIILPDRLYAFVQLYQLL 455
|
|
| GumC |
COG3206 |
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis]; |
396-601 |
6.63e-03 |
|
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442439 [Multi-domain] Cd Length: 687 Bit Score: 40.39 E-value: 6.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 396 FQQAESALQTLDQQIQVKRKEKEAAQLQLATLDSQRSSLNIISEHIERRTRLQQLTQQLHDKAQLHQQAEQAYKEAQEKT 475
Cdd:COG3206 170 REEARKALEFLEEQLPELRKELEEAEAALEEFRQKNGLVDLSEEAKLLLQQLSELESQLAEARAELAEAEARLAALRAQL 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 476 RLAKQRADQL-----------EYVWHTNQAAELAKLLQEgdacpvcgshSHPQLAQfsgdvvTKEQVQQARdhqqtaANT 544
Cdd:COG3206 250 GSGPDALPELlqspviqqlraQLAELEAELAELSARYTP----------NHPDVIA------LRAQIAALR------AQL 307
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 2176024252 545 ETQALKRHEALTAEHQHLKQDVELLETAIK--EKRIPELAELHAKQTQLTTEIARLQAL 601
Cdd:COG3206 308 QQEAQRILASLEAELEALQAREASLQAQLAqlEARLAELPELEAELRRLEREVEVAREL 366
|
|
| KpsE |
COG3524 |
Capsule polysaccharide export protein KpsE/RkpR [Cell wall/membrane/envelope biogenesis]; |
308-488 |
7.82e-03 |
|
Capsule polysaccharide export protein KpsE/RkpR [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442746 [Multi-domain] Cd Length: 370 Bit Score: 39.83 E-value: 7.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 308 NEMN--AAEKQLNQAQSAVVARTDAVALATKQVTEADTVYQAaISNCSQLESLTAQLHQLEATgkkfaaLDEQQKQLAAA 385
Cdd:COG3524 168 NQLSerAREDAVRFAEEEVERAEERLRDAREALLAFRNRNGI-LDPEATAEALLQLIATLEGQ------LAELEAELAAL 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 386 SQLFTSAKHAFQQAESALQTLDQQIQvkrkeKEAAQLqlaTLDSQRSSLNIISEHIERrtrlqqltqqlhdkAQLHQQ-A 464
Cdd:COG3524 241 RSYLSPNSPQVRQLRRRIAALEKQIA-----AERARL---TGASGGDSLASLLAEYER--------------LELEREfA 298
|
170 180
....*....|....*....|....*..
gi 2176024252 465 EQAYKEAQ---EKTRLAKQRadQLEYV 488
Cdd:COG3524 299 EKAYTSALaalEQARIEAAR--QQRYL 323
|
|
| ABC_cobalt_CbiO_domain1 |
cd03225 |
First domain of the ATP-binding cassette component of cobalt transport system; Domain I of the ... |
913-986 |
8.13e-03 |
|
First domain of the ATP-binding cassette component of cobalt transport system; Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC transport system of the CbiMNQO family is involved in cobalt transport in association with the cobalamin (vitamin B12) biosynthetic pathways. Most of cobalt (Cbi) transport systems possess a separate CbiN component, the cobalt-binding periplasmic protein, and they are encoded by the conserved gene cluster cbiMNQO. Both the CbiM and CbiQ proteins are integral cytoplasmic membrane proteins, and the CbiO protein has the linker peptide and the Walker A and B motifs commonly found in the ATPase components of the ABC-type transport systems.
Pssm-ID: 213192 [Multi-domain] Cd Length: 211 Bit Score: 38.99 E-value: 8.13e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2176024252 913 RDVATLSGGESFMAALSLALGLsdvvqsysggiRLDTLFIDEGFGSLDPESLDLAIQTLIDLQQGGRTIGIISH 986
Cdd:cd03225 130 RSPFTLSGGQKQRVAIAGVLAM-----------DPDILLLDEPTAGLDPAGRRELLELLKKLKAEGKTIIIVTH 192
|
|
| MukB |
COG3096 |
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ... |
373-600 |
8.62e-03 |
|
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 442330 [Multi-domain] Cd Length: 1470 Bit Score: 40.32 E-value: 8.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 373 AALDEQQKQLAAASQLFTSAKHAFQQAESALQTLDQQIQVKRK----------EKEAAQLQLAT--LDSQRSSLNIISEH 440
Cdd:COG3096 836 AELAALRQRRSELERELAQHRAQEQQLRQQLDQLKEQLQLLNKllpqanlladETLADRLEELReeLDAAQEAQAFIQQH 915
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 441 IERRTRLQQLTQQLHDKAQLHQQAEQAYKEAQEKTRLAKQRADQLEYV--------WH-----TNQAAELAKLLQEgdac 507
Cdd:COG3096 916 GKALAQLEPLVAVLQSDPEQFEQLQADYLQAKEQQRRLKQQIFALSEVvqrrphfsYEdavglLGENSDLNEKLRA---- 991
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176024252 508 pvCGSHSHPQLAQfsgdvvTKEQVQQArDHQQTAANTETQALK-RHEALTAEHQHLKQDVELLETAI-----------KE 575
Cdd:COG3096 992 --RLEQAEEARRE------AREQLRQA-QAQYSQYNQVLASLKsSRDAKQQTLQELEQELEELGVQAdaeaeerarirRD 1062
|
250 260
....*....|....*....|....*
gi 2176024252 576 KRIPELAELHAKQTQLTTEIARLQA 600
Cdd:COG3096 1063 ELHEELSQNRSRRSQLEKQLTRCEA 1087
|
|
| |
