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Conserved domains on  [gi|2176887570|ref|WP_234154973|]
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deoxyguanosinetriphosphate triphosphohydrolase [Bacteroides thetaiotaomicron]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK01096 super family cl35137
deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional
 2-446 1.09e-158

deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional


The actual alignment was detected with superfamily member PRK01096:

Pssm-ID: 234897 [Multi-domain]  Cd Length: 440  Bit Score: 455.92  E-value: 1.09e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570   2 MNWKQLISAKRFGMEEFHEERQENRSEFQRDYDRLIFSAPFRRLQNKTQVFPLPGSIFVHNRLTHSLEVSCVGRSLGNDV 81
Cdd:PRK01096    1 MDWDTLLSRERLGKKGKTSKDELGRSPFHKDYDRIIFSGSFRRLQRKTQVHPLAKNDHIHTRLTHSLEVSCVGRSLGMRV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570  82 AKAILERQ-PELESSFlpEIGSIVSAACLAHDLGNPPFGHSGERAISTFFSEGKGQRLQEKqpdgeqLSPMEWEDLTHFE 160
Cdd:PRK01096   81 GETLKEEKlPDWISPA--DIGAIVQSACLAHDIGNPPFGHFGEDAIREWFQDAAGRGFLDD------LSPQERADFLNFE 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570 161 GNANAFRILT----HQFEgrrrGGFVLTYSTLASIVKYPFSS----SLAGKKSKFGFFVSEEESYRKIATELGLIQLSEQ 232
Cdd:PRK01096  153 GNAQGFRVLTkleyHQDD----GGMRLTYATLGTYIKYPWSSrhanKQQIKKKKFGCYQSELPLFEQIAEALGLPQLGEQ 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570 233 plKYARHPLVYLVEAADDICYQMMDIEDAHKLKIITTDETKELLMAfFSEDRQSRLRSTFQivNDINEQIAYLRSSVIGL 312
Cdd:PRK01096  229 --RWCRHPLTYLLEAADDICYALIDLEDGLEMGLLNYQEVEALFLE-LIGDKEKYRQLGPQ--DSRRQKLARLRGKAIGR 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570 313 LVRECTRVFLEHEQEILAGTFEGALIKH----ISEGPAAAYNhcaeISLKKIYRSQDVLDIELAGFRIISTLLELMVDAV 388
Cdd:PRK01096  304 LVNAVAEAFVENYDAILAGTLPGDLIEHcdpdAKRCVQQAKD----LAREKIFQHKRKVELEIGAYTILEILLDAFVPAA 379

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2176887570 389 -------TLPGKEKAYSELLTNrvsdqyNIKSPV--LYERIQAVLDYISGMTDVFALDLYRKINGNS 446
Cdd:PRK01096  380 lyydsgtTPSFKDKRLLDLLGD------NAPDPTmkLYLRLLRVLDFISGMTDSYAKELAQELTGRS 440
 
Name Accession Description Interval E-value
PRK01096 PRK01096
deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional
 2-446 1.09e-158

deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional


Pssm-ID: 234897 [Multi-domain]  Cd Length: 440  Bit Score: 455.92  E-value: 1.09e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570   2 MNWKQLISAKRFGMEEFHEERQENRSEFQRDYDRLIFSAPFRRLQNKTQVFPLPGSIFVHNRLTHSLEVSCVGRSLGNDV 81
Cdd:PRK01096    1 MDWDTLLSRERLGKKGKTSKDELGRSPFHKDYDRIIFSGSFRRLQRKTQVHPLAKNDHIHTRLTHSLEVSCVGRSLGMRV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570  82 AKAILERQ-PELESSFlpEIGSIVSAACLAHDLGNPPFGHSGERAISTFFSEGKGQRLQEKqpdgeqLSPMEWEDLTHFE 160
Cdd:PRK01096   81 GETLKEEKlPDWISPA--DIGAIVQSACLAHDIGNPPFGHFGEDAIREWFQDAAGRGFLDD------LSPQERADFLNFE 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570 161 GNANAFRILT----HQFEgrrrGGFVLTYSTLASIVKYPFSS----SLAGKKSKFGFFVSEEESYRKIATELGLIQLSEQ 232
Cdd:PRK01096  153 GNAQGFRVLTkleyHQDD----GGMRLTYATLGTYIKYPWSSrhanKQQIKKKKFGCYQSELPLFEQIAEALGLPQLGEQ 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570 233 plKYARHPLVYLVEAADDICYQMMDIEDAHKLKIITTDETKELLMAfFSEDRQSRLRSTFQivNDINEQIAYLRSSVIGL 312
Cdd:PRK01096  229 --RWCRHPLTYLLEAADDICYALIDLEDGLEMGLLNYQEVEALFLE-LIGDKEKYRQLGPQ--DSRRQKLARLRGKAIGR 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570 313 LVRECTRVFLEHEQEILAGTFEGALIKH----ISEGPAAAYNhcaeISLKKIYRSQDVLDIELAGFRIISTLLELMVDAV 388
Cdd:PRK01096  304 LVNAVAEAFVENYDAILAGTLPGDLIEHcdpdAKRCVQQAKD----LAREKIFQHKRKVELEIGAYTILEILLDAFVPAA 379

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2176887570 389 -------TLPGKEKAYSELLTNrvsdqyNIKSPV--LYERIQAVLDYISGMTDVFALDLYRKINGNS 446
Cdd:PRK01096  380 lyydsgtTPSFKDKRLLDLLGD------NAPDPTmkLYLRLLRVLDFISGMTDSYAKELAQELTGRS 440
Dgt COG0232
dGTP triphosphohydrolase [Nucleotide transport and metabolism];
24-442 1.42e-135

dGTP triphosphohydrolase [Nucleotide transport and metabolism];


Pssm-ID: 440002 [Multi-domain]  Cd Length: 345  Bit Score: 393.36  E-value: 1.42e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570  24 ENRSEFQRDYDRLIFSAPFRRLQNKTQVFPLPGSIFVHNRLTHSLEVSCVGRSLGNDVAkailerqpelessflpEIGSI 103
Cdd:COG0232     2 DIRSPFQRDRDRIIHSAAFRRLQDKTQVFPLPEGDHYRTRLTHSLEVAQIARSIARALG----------------LNEDL 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570 104 VSAACLAHDLGNPPFGHSGERAISTFFsegkgqrlqekqpdgeqlspmewEDLTHFEGNANAFRILTHQFEGRRRGGFVL 183
Cdd:COG0232    66 VEAAALAHDLGHPPFGHAGEDALNELF-----------------------RDLGGFEGNAQSLRILTRLEKRYAFGGLNL 122

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570 184 TYSTLASIVKYPFSSSLAGKKSKFGFFVSEEESYRKIATELGLIqlseqPLKYARHPLVYLVEAADDICYQMMDIEDAHK 263
Cdd:COG0232   123 TYATLDGILKYPGPSLAAPKPKPKGFYQSEKDVFDWVREELGLL-----ALGRPRTLEAQIVELADDIAYSVHDLEDAIR 197

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570 264 LKIITTDETKELLMAFFSEDRqsrlrstfqivndiNEQIAYLRSSVIGLLVRECTRVFLEHEqeilagtFEGALIkHISE 343
Cdd:COG0232   198 AGLLSLEDLPELLEYLGPLDE--------------RRRLGELRSRLIGRLVTDVIEASRENL-------FDGPLI-AFSP 255

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570 344 GPAAAYNHCAEISLKKIYRSQDVLDIELAGFRIISTLLElmvdavtlpgkekAYSELLTNRVSDQYNIK---SPVLYERI 420
Cdd:COG0232   256 EVAAALKELKKFLFERVYRHPEVLRLELKGRRIIRELFD-------------AFLEDPLELLPEEFRERyeaADDEYGRL 322

                         410       420
                  ....*....|....*....|..
gi 2176887570 421 QAVLDYISGMTDVFALDLYRKI 442
Cdd:COG0232   323 RVVADYIAGMTDRYALRLYRRL 344
dGTP_triPase TIGR01353
deoxyguanosinetriphosphate triphosphohydrolase, putative; dGTP triphosphohydrolase (dgt) ...
 25-444 1.28e-129

deoxyguanosinetriphosphate triphosphohydrolase, putative; dGTP triphosphohydrolase (dgt) releases inorganic triphosphate, an unusual activity reaction product, from GTP. Its activity has been called limited to the Enterobacteriaceae, although homologous sequences are detected elsewhere. This finding casts doubt on whether the activity is shared in other species. In several of these other species, the homologous gene is found in an apparent operon with dnaG, the DNA primase gene. The enzyme from E. coli was shown to bind coopertatively to single stranded DNA. The biological role of dgt is unknown. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273571 [Multi-domain]  Cd Length: 381  Bit Score: 379.79  E-value: 1.28e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570  25 NRSEFQRDYDRLIFSAPFRRLQNKTQVFPLPGSIFVHNRLTHSLEVSCVGRSLGNDVakaILERQPELESsfLPEIGSIV 104
Cdd:TIGR01353   1 ERTPFERDYDRIIHSSAFRRLQDKTQVFPLAENDFVRTRLTHSLEVAQVGRSIANLI---GLRYDLELEE--LGPFERLA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570 105 SAACLAHDLGNPPFGHSGERAISTFFSEGKgqrlqekqpdgeqlspmewedlTHFEGNANAFRILTHQFEGRR-RGGFVL 183
Cdd:TIGR01353  76 ETACLAHDIGNPPFGHAGERALNDWMREYG----------------------PGFEGNAQTFRILTTLEKRRRaKGGLNL 133

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570 184 TYSTLASIVKYPFSSSL-----AGKKSKFGFFVSEEESYRKIATELGLIqlseqplkYARHPLVYLVEAADDICYQMMDI 258
Cdd:TIGR01353 134 TWRTLAGILKYPRPSSEdafkgGYLNKKKGIYDSELAVFDRVAELLGLT--------WYRSPLAQLMEAADDIAYTVHDL 205

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570 259 EDAHKLKIITTDETKELLMAFFSEDRqSRLRSTFQIVNDINEQIAYLRSSVIGLLVRECT-RVFLEHEQEILAGTFEGAL 337
Cdd:TIGR01353 206 EDAIKLGLLTFDDLQHLLLIQAGFEE-LGSEMTDLSISAENEQIRSLRGKLITDLIESVAkAEFSSHLVAILIGTFHHTL 284

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570 338 IKHiSEGPAAAYNHCAEISLKKIYRSQDVLDIELAGFRIISTLLELMVDAVtlpgkekaYSELLTNRVSDQYNiKSPVLY 417
Cdd:TIGR01353 285 VEF-SPRLAELLEALKKFLRKRVYRHPDVERIEYQGEQIITGLFDAFMPDL--------PPRLLPPELRSKLR-KAEDNY 354

                         410       420
                  ....*....|....*....|....*..
gi 2176887570 418 ERIQAVLDYISGMTDVFALDLYRKING 444
Cdd:TIGR01353 355 YKARVVCDYIAGMTDRYALEEYRRLFG 381
antiphage_dGTPase NF041026
anti-phage deoxyguanosine triphosphatase; Proteins of this family are distant homologues of ...
 16-442 5.51e-54

anti-phage deoxyguanosine triphosphatase; Proteins of this family are distant homologues of human antiviral protein SAMHD1. It has been shown that proteins of this family protected bacteria from phage infection by degrading dGTP into phosphate-free deoxyguanosine. The anti-phage dGTPase may also be involved in other biological processes.


Pssm-ID: 468955 [Multi-domain]  Cd Length: 426  Bit Score: 185.79  E-value: 5.51e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570  16 EEFHEERQENRSEFQRDYDRLIFSAPFRRLQNKTQVFPLPGSIFVHNRLTHSLEVSCVGRSLgndvAKAILERQPELESS 95
Cdd:NF041026    7 GEEKKRRNDHRSPFQRDRARIIHSAAFRRLQAKTQVLGLGESDFYRTRLTHSLEVAQIGTGI----VAQLKAKQPEPLRA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570  96 FLPEIgSIVSAACLAHDLGNPPFGHSGERAISTFFSEGKGqrlqekqpdgeqlspmewedlthFEGNANAFRILThQFEG 175
Cdd:NF041026   83 LLPDD-SLIEAICLAHDIGHPPFGHGGEVALNYMMRDHGG-----------------------FEGNGQTLRILT-KLEP 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570 176 R-RRGGFVLTYSTLASIVKYP--FSSSLAGKKSKF----------------GFFVSEEESYRKIATELG------LIQLS 230
Cdd:NF041026  138 YtEHHGMNLTRRTLLGVLKYPalYSQVQAPQLPPKvsnfrqlkasdwkppkGYYDCDQDVVDWVLAPLSendralFTSLD 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570 231 EQPLKYARHPLvY------LVEAADDICYQMMDIEDAHKLKIITTDETKEllmAFFSEDRQSRLRSTFQIVNDINEQI-- 302
Cdd:NF041026  218 EKPGKQHGKTR-FksldcsIMELADDIAYGVHDLEDAIVLGLVTREQWQE---AVAPKLAALGDPWLSDNLDELSDKLfs 293

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570 303 --AYLRSSVIGLLVREC-TRVFLEHEQEilagtFEGALIKH---ISEGPAAAYNHCAEISLKKIYRSQDVLDIELAGFRI 376
Cdd:NF041026  294 geHYERKDAIGALVNYFiTSIEIKEVDA-----FEEPLLRYnavLPPEVAALLEVLKQFVYQYVIRSPEVQQLEYKGQQI 368

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2176887570 377 ISTLLE-LMVDavtlPGKekayseLLTNRVSDQYN--IKSPVLYERIqaVLDYISGMTDVFALDLYRKI 442
Cdd:NF041026  369 VMELFEaLASD----PER------LLPENTRERWQeaEEDGENGKRV--ICDYIAGMTDEYALRLYQRL 425
HD_assoc pfam13286
Phosphohydrolase-associated domain; This domain is found on bacterial and archaeal ...
 358-441 1.41e-06

Phosphohydrolase-associated domain; This domain is found on bacterial and archaeal metal-dependent phosphohydrolases.


Pssm-ID: 433087 [Multi-domain]  Cd Length: 91  Bit Score: 46.37  E-value: 1.41e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570 358 KKIYRSQDVLDIELAGFRIISTLLE-LMVDAVTLPGkekAYSELLTNRVSDqynikspvlyERIQAVLDYISGMTDVFAL 436
Cdd:pfam13286  20 EYVYRHPRVQREEEKARRIIRELFEaLMADPELLPP---EFRARWEAAGDD----------ARARVVCDYIAGMTDRYAL 86


                  ....*
gi 2176887570 437 DLYRK 441
Cdd:pfam13286  87 RLHRR 91
HDc smart00471
Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic ...
 61-137 3.73e-03

Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic nucleotide phosphodiesterases (PDEc). This profile/HMM does not detect HD homologues in bacterial glycine aminoacyl-tRNA synthetases (beta subunit).


Pssm-ID: 214679 [Multi-domain]  Cd Length: 124  Bit Score: 37.28  E-value: 3.73e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2176887570   61 HNRLTHSLEVSCVGRSLgndvAKAILERQPELessflpeigsiVSAACLAHDLGNPPFGHSGERAISTFFSEGKGQR 137
Cdd:smart00471   3 YHVFEHSLRVAQLAAAL----AEELGLLDIEL-----------LLLAALLHDIGKPGTPDSFLVKTSVLEDHHFIGA 64
 
Name Accession Description Interval E-value
PRK01096 PRK01096
deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional
 2-446 1.09e-158

deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional


Pssm-ID: 234897 [Multi-domain]  Cd Length: 440  Bit Score: 455.92  E-value: 1.09e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570   2 MNWKQLISAKRFGMEEFHEERQENRSEFQRDYDRLIFSAPFRRLQNKTQVFPLPGSIFVHNRLTHSLEVSCVGRSLGNDV 81
Cdd:PRK01096    1 MDWDTLLSRERLGKKGKTSKDELGRSPFHKDYDRIIFSGSFRRLQRKTQVHPLAKNDHIHTRLTHSLEVSCVGRSLGMRV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570  82 AKAILERQ-PELESSFlpEIGSIVSAACLAHDLGNPPFGHSGERAISTFFSEGKGQRLQEKqpdgeqLSPMEWEDLTHFE 160
Cdd:PRK01096   81 GETLKEEKlPDWISPA--DIGAIVQSACLAHDIGNPPFGHFGEDAIREWFQDAAGRGFLDD------LSPQERADFLNFE 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570 161 GNANAFRILT----HQFEgrrrGGFVLTYSTLASIVKYPFSS----SLAGKKSKFGFFVSEEESYRKIATELGLIQLSEQ 232
Cdd:PRK01096  153 GNAQGFRVLTkleyHQDD----GGMRLTYATLGTYIKYPWSSrhanKQQIKKKKFGCYQSELPLFEQIAEALGLPQLGEQ 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570 233 plKYARHPLVYLVEAADDICYQMMDIEDAHKLKIITTDETKELLMAfFSEDRQSRLRSTFQivNDINEQIAYLRSSVIGL 312
Cdd:PRK01096  229 --RWCRHPLTYLLEAADDICYALIDLEDGLEMGLLNYQEVEALFLE-LIGDKEKYRQLGPQ--DSRRQKLARLRGKAIGR 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570 313 LVRECTRVFLEHEQEILAGTFEGALIKH----ISEGPAAAYNhcaeISLKKIYRSQDVLDIELAGFRIISTLLELMVDAV 388
Cdd:PRK01096  304 LVNAVAEAFVENYDAILAGTLPGDLIEHcdpdAKRCVQQAKD----LAREKIFQHKRKVELEIGAYTILEILLDAFVPAA 379

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2176887570 389 -------TLPGKEKAYSELLTNrvsdqyNIKSPV--LYERIQAVLDYISGMTDVFALDLYRKINGNS 446
Cdd:PRK01096  380 lyydsgtTPSFKDKRLLDLLGD------NAPDPTmkLYLRLLRVLDFISGMTDSYAKELAQELTGRS 440
Dgt COG0232
dGTP triphosphohydrolase [Nucleotide transport and metabolism];
24-442 1.42e-135

dGTP triphosphohydrolase [Nucleotide transport and metabolism];


Pssm-ID: 440002 [Multi-domain]  Cd Length: 345  Bit Score: 393.36  E-value: 1.42e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570  24 ENRSEFQRDYDRLIFSAPFRRLQNKTQVFPLPGSIFVHNRLTHSLEVSCVGRSLGNDVAkailerqpelessflpEIGSI 103
Cdd:COG0232     2 DIRSPFQRDRDRIIHSAAFRRLQDKTQVFPLPEGDHYRTRLTHSLEVAQIARSIARALG----------------LNEDL 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570 104 VSAACLAHDLGNPPFGHSGERAISTFFsegkgqrlqekqpdgeqlspmewEDLTHFEGNANAFRILTHQFEGRRRGGFVL 183
Cdd:COG0232    66 VEAAALAHDLGHPPFGHAGEDALNELF-----------------------RDLGGFEGNAQSLRILTRLEKRYAFGGLNL 122

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570 184 TYSTLASIVKYPFSSSLAGKKSKFGFFVSEEESYRKIATELGLIqlseqPLKYARHPLVYLVEAADDICYQMMDIEDAHK 263
Cdd:COG0232   123 TYATLDGILKYPGPSLAAPKPKPKGFYQSEKDVFDWVREELGLL-----ALGRPRTLEAQIVELADDIAYSVHDLEDAIR 197

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570 264 LKIITTDETKELLMAFFSEDRqsrlrstfqivndiNEQIAYLRSSVIGLLVRECTRVFLEHEqeilagtFEGALIkHISE 343
Cdd:COG0232   198 AGLLSLEDLPELLEYLGPLDE--------------RRRLGELRSRLIGRLVTDVIEASRENL-------FDGPLI-AFSP 255

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570 344 GPAAAYNHCAEISLKKIYRSQDVLDIELAGFRIISTLLElmvdavtlpgkekAYSELLTNRVSDQYNIK---SPVLYERI 420
Cdd:COG0232   256 EVAAALKELKKFLFERVYRHPEVLRLELKGRRIIRELFD-------------AFLEDPLELLPEEFRERyeaADDEYGRL 322

                         410       420
                  ....*....|....*....|..
gi 2176887570 421 QAVLDYISGMTDVFALDLYRKI 442
Cdd:COG0232   323 RVVADYIAGMTDRYALRLYRRL 344
dGTP_triPase TIGR01353
deoxyguanosinetriphosphate triphosphohydrolase, putative; dGTP triphosphohydrolase (dgt) ...
 25-444 1.28e-129

deoxyguanosinetriphosphate triphosphohydrolase, putative; dGTP triphosphohydrolase (dgt) releases inorganic triphosphate, an unusual activity reaction product, from GTP. Its activity has been called limited to the Enterobacteriaceae, although homologous sequences are detected elsewhere. This finding casts doubt on whether the activity is shared in other species. In several of these other species, the homologous gene is found in an apparent operon with dnaG, the DNA primase gene. The enzyme from E. coli was shown to bind coopertatively to single stranded DNA. The biological role of dgt is unknown. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273571 [Multi-domain]  Cd Length: 381  Bit Score: 379.79  E-value: 1.28e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570  25 NRSEFQRDYDRLIFSAPFRRLQNKTQVFPLPGSIFVHNRLTHSLEVSCVGRSLGNDVakaILERQPELESsfLPEIGSIV 104
Cdd:TIGR01353   1 ERTPFERDYDRIIHSSAFRRLQDKTQVFPLAENDFVRTRLTHSLEVAQVGRSIANLI---GLRYDLELEE--LGPFERLA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570 105 SAACLAHDLGNPPFGHSGERAISTFFSEGKgqrlqekqpdgeqlspmewedlTHFEGNANAFRILTHQFEGRR-RGGFVL 183
Cdd:TIGR01353  76 ETACLAHDIGNPPFGHAGERALNDWMREYG----------------------PGFEGNAQTFRILTTLEKRRRaKGGLNL 133

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570 184 TYSTLASIVKYPFSSSL-----AGKKSKFGFFVSEEESYRKIATELGLIqlseqplkYARHPLVYLVEAADDICYQMMDI 258
Cdd:TIGR01353 134 TWRTLAGILKYPRPSSEdafkgGYLNKKKGIYDSELAVFDRVAELLGLT--------WYRSPLAQLMEAADDIAYTVHDL 205

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570 259 EDAHKLKIITTDETKELLMAFFSEDRqSRLRSTFQIVNDINEQIAYLRSSVIGLLVRECT-RVFLEHEQEILAGTFEGAL 337
Cdd:TIGR01353 206 EDAIKLGLLTFDDLQHLLLIQAGFEE-LGSEMTDLSISAENEQIRSLRGKLITDLIESVAkAEFSSHLVAILIGTFHHTL 284

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570 338 IKHiSEGPAAAYNHCAEISLKKIYRSQDVLDIELAGFRIISTLLELMVDAVtlpgkekaYSELLTNRVSDQYNiKSPVLY 417
Cdd:TIGR01353 285 VEF-SPRLAELLEALKKFLRKRVYRHPDVERIEYQGEQIITGLFDAFMPDL--------PPRLLPPELRSKLR-KAEDNY 354

                         410       420
                  ....*....|....*....|....*..
gi 2176887570 418 ERIQAVLDYISGMTDVFALDLYRKING 444
Cdd:TIGR01353 355 YKARVVCDYIAGMTDRYALEEYRRLFG 381
dgt PRK04926
deoxyguanosinetriphosphate triphosphohydrolase; Provisional
 1-444 9.49e-85

deoxyguanosinetriphosphate triphosphohydrolase; Provisional


Pssm-ID: 235320 [Multi-domain]  Cd Length: 503  Bit Score: 268.72  E-value: 9.49e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570   1 MMNWKQLISAKRF--GMEEFHEERQENRsEFQRDYDRLIFSAPFRRLQNKTQVFPLPGSIFVHNRLTHSLEVSCVGRSLg 78
Cdd:PRK04926    3 MIDFRKKINWQRRyrSPQGVKTEHEILR-IFESDRGRIINSAAIRRLQQKTQVFPLERNAAVRSRLTHSLEVQQVGRYI- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570  79 ndvAKAILERQPE---LESSFLPEI----GSIVSAACLAHDLGNPPFGHSGERAISTFFSEG-----------------K 134
Cdd:PRK04926   81 ---AKEILSRLKEqklLEAYGLDELtgpfESIVEMACLMHDIGNPPFGHFGEAAINDWFRQRldpdaesqpltddrcsvA 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570 135 GQRLQEKQPDGEQLSPMEWEDLTHFEGNANAFRILTHQFegrrrgGFVLTYSTLASIVKY--------PFSSSLAGKKSK 206
Cdd:PRK04926  158 ALRLRDGEEPLNELRRKIRQDLCHFEGNAQGIRLVHTLL------RLNLTYAQVACILKYtrpawwrgPTPASHHYLMKK 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570 207 FGFFVSEEESYRKIATELGLiqlseqpLKYARHPLVYLVEAADDICYQMMDIEDAHKLKIITTDETKELLMAFFSEDRQS 286
Cdd:PRK04926  232 PGYYLSEEAYVARLRKELNL-------APYSRFPLTYIMEAADDISYCIADLEDAVEKRIFSVEQLYHHLHEAWGEHEKG 304

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570 287 RL-----------RSTFQIVNDINEQI-AYLRSSVIGLLVRECTRVFLEHEQEILAGTFEGALIKHISEGpAAAYNHCAE 354
Cdd:PRK04926  305 DLfslvvenawekSRANSLSRSSEDQFfMYLRVNTLNKLVPYAAQRFIDNLPAIFAGTFNQALLEDASPA-SRLLKTFKN 383

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570 355 ISLKKIYRSQDVLDIELAGFRIISTLLE-----LMVDAVT----------------------LPGKE-KAYSELLT--NR 404
Cdd:PRK04926  384 VARKHVFSHPEVEQLELQGYRVISGLLDiysplLALPLEDftelvekerhkrypietrlfhkLSTRHrLAYVEAVSklPS 463

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|..
gi 2176887570 405 VSDQYniksPVL--YERIQAVLDYISGMTDVFALDLYRKING 444
Cdd:PRK04926  464 DSPEF----PLWeyYYRARLIQDYISGMTDLYAWDEYRRLMA 501
antiphage_dGTPase NF041026
anti-phage deoxyguanosine triphosphatase; Proteins of this family are distant homologues of ...
 16-442 5.51e-54

anti-phage deoxyguanosine triphosphatase; Proteins of this family are distant homologues of human antiviral protein SAMHD1. It has been shown that proteins of this family protected bacteria from phage infection by degrading dGTP into phosphate-free deoxyguanosine. The anti-phage dGTPase may also be involved in other biological processes.


Pssm-ID: 468955 [Multi-domain]  Cd Length: 426  Bit Score: 185.79  E-value: 5.51e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570  16 EEFHEERQENRSEFQRDYDRLIFSAPFRRLQNKTQVFPLPGSIFVHNRLTHSLEVSCVGRSLgndvAKAILERQPELESS 95
Cdd:NF041026    7 GEEKKRRNDHRSPFQRDRARIIHSAAFRRLQAKTQVLGLGESDFYRTRLTHSLEVAQIGTGI----VAQLKAKQPEPLRA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570  96 FLPEIgSIVSAACLAHDLGNPPFGHSGERAISTFFSEGKGqrlqekqpdgeqlspmewedlthFEGNANAFRILThQFEG 175
Cdd:NF041026   83 LLPDD-SLIEAICLAHDIGHPPFGHGGEVALNYMMRDHGG-----------------------FEGNGQTLRILT-KLEP 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570 176 R-RRGGFVLTYSTLASIVKYP--FSSSLAGKKSKF----------------GFFVSEEESYRKIATELG------LIQLS 230
Cdd:NF041026  138 YtEHHGMNLTRRTLLGVLKYPalYSQVQAPQLPPKvsnfrqlkasdwkppkGYYDCDQDVVDWVLAPLSendralFTSLD 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570 231 EQPLKYARHPLvY------LVEAADDICYQMMDIEDAHKLKIITTDETKEllmAFFSEDRQSRLRSTFQIVNDINEQI-- 302
Cdd:NF041026  218 EKPGKQHGKTR-FksldcsIMELADDIAYGVHDLEDAIVLGLVTREQWQE---AVAPKLAALGDPWLSDNLDELSDKLfs 293

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570 303 --AYLRSSVIGLLVREC-TRVFLEHEQEilagtFEGALIKH---ISEGPAAAYNHCAEISLKKIYRSQDVLDIELAGFRI 376
Cdd:NF041026  294 geHYERKDAIGALVNYFiTSIEIKEVDA-----FEEPLLRYnavLPPEVAALLEVLKQFVYQYVIRSPEVQQLEYKGQQI 368

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2176887570 377 ISTLLE-LMVDavtlPGKekayseLLTNRVSDQYN--IKSPVLYERIqaVLDYISGMTDVFALDLYRKI 442
Cdd:NF041026  369 VMELFEaLASD----PER------LLPENTRERWQeaEEDGENGKRV--ICDYIAGMTDEYALRLYQRL 425
PRK05318 PRK05318
deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional
 1-442 3.14e-49

deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional


Pssm-ID: 235403 [Multi-domain]  Cd Length: 432  Bit Score: 173.52  E-value: 3.14e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570   1 MMNWKQlisaKRFGMEEfhEERQENRSEFQRDYDRLIFSAPFRRLQNKTQVFPLPGSIFVHNRLTHSLEVSCVGRSLgnd 80
Cdd:PRK05318    3 SSVWQE----RRLGEDK--QRRNDHRSPYQRDRARILHSAAFRRLQAKTQVLGVGENDFYRTRLTHSLEVAQIGTGI--- 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570  81 VAKAILERQPELESsfLPEIGSIVSAACLAHDLGNPPFGHSGERAISTFFSEGKGqrlqekqpdgeqlspmewedlthFE 160
Cdd:PRK05318   74 VAQLKKEKQPELKP--LLPSDSLIESLCLAHDIGHPPFGHGGEVALNYMMRDHGG-----------------------FE 128

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570 161 GNANAFRILThQFEGRRRG-GFVLTYSTLASIVKYP-FSSSLAGKKSkfgffVSEEESYRKIAT------------ELGL 226
Cdd:PRK05318  129 GNGQTFRILT-KLEPYTEHfGMNLTRRTLLGILKYPaLYSELVAQYP-----PPDVANHRQLKAsdwkppkgifddDQDI 202

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570 227 IQ-----LSE------QPLKYARHPLVY------------LVEAADDICYQMMDIEDAHKLKIITTDETKELLMAFFSED 283
Cdd:PRK05318  203 FDwvlepLSEndralfQSLRPEPDSPKEhlktryksldcsIMELADDIAYGVHDLEDAIVLGLVTRSQWQEDVAPQLAQC 282

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570 284 RQSRLRSTFqivNDINEQI----AYLRSSVIGLLVREctrvFLEHEQEILAGTFEGALIKH---ISEGPAAAYNHCAEIS 356
Cdd:PRK05318  283 GDPWLEEEI---ETIGEKLfsgeHHLRKDAIGTLVNY----FITSIRIKENEEFEEPLLRYnaaLEPEFAAALEVLKQFV 355

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570 357 LKKIYRSQDVLDIELAGFRIISTLLElmvdavtlpgkekAYSE----LLTNRVSDQYnIKSPVLYERIQAVLDYISGMTD 432
Cdd:PRK05318  356 YKYVIRKPEVQRLEYKGQQIVMELFE-------------ALSSdperLLPRNTQERW-RKAEDEENSMRVICDYISGMTD 421

                         490
                  ....*....|
gi 2176887570 433 VFALDLYRKI 442
Cdd:PRK05318  422 EYAYRLYQQL 431
PRK01286 PRK01286
deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional
 17-442 6.97e-38

deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional


Pssm-ID: 234934 [Multi-domain]  Cd Length: 336  Bit Score: 140.69  E-value: 6.97e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570  17 EFHEERQENRSEFQRDYDRLIFSAPFRRLQNKTQVFPLPGSIFVHNRLTHSLEVSCVGRSlgndVAKAIlerqpelessF 96
Cdd:PRK01286   17 LRPEEPCPIRTEFQRDRDRIIHSKAFRRLKHKTQVFINPEGDHYRTRLTHTLEVAQIART----IARAL----------R 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570  97 LPEigSIVSAACLAHDLGNPPFGHSGERAISTFFSEGKGqrlqekqpdgeqlspmewedlthFEGNANAFRILThQFEGR 176
Cdd:PRK01286   83 LNE--DLTEAIALGHDLGHTPFGHAGEDALNELMKEYGG-----------------------FEHNEQSLRVVD-KLEKR 136

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570 177 RRgGFVLTYSTLASIVKYpfSSSLAGKKSKFgffvseeesyrkiATelgliqLSEQplkyarhplvyLVEAADDICYQMM 256
Cdd:PRK01286  137 YD-GLNLTWEVREGILKH--SGPRNAPLGTA-------------AT------LEGQ-----------IVRLADEIAYNNH 183

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570 257 DIEDAHKLKIITTDetkellmaffsedrqsrlrstfQIVNDINEQIAYLRSSVIGLLVRECTRVFLEHEQEILAGTfega 336
Cdd:PRK01286  184 DIDDGIRAGLITLE----------------------DLPEDVRRLLGETHRRRINTLVVDLIKNTQRNLAEGAAAP---- 237

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570 337 liKHISEGPAAaynHCAEISLKK-----IYRSQDVLDIELAGFRIISTLLE-LMVDAVTLPGKEKAYSElltnrvsdqyn 410
Cdd:PRK01286  238 --PLVSFSEEV---AEAMKELRRflfenVYRHPKVKREREKAKRIVQDLFEyYMEDPELLPPEYQNIAE----------- 301

                         410       420       430
                  ....*....|....*....|....*....|..
gi 2176887570 411 ikspvLYERIQAVLDYISGMTDVFALDLYRKI 442
Cdd:PRK01286  302 -----EEGLERAVADYIAGMTDRYALREYRRL 328
PRK03007 PRK03007
deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional
 11-261 1.27e-34

deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional


Pssm-ID: 235098 [Multi-domain]  Cd Length: 428  Bit Score: 133.53  E-value: 1.27e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570  11 KRFGMEEFHEER--------------QENRSEFQRDYDRLIFSAPFRRLQNKTQVF-PLPGSiFVHNRLTHSLEVSCVGR 75
Cdd:PRK03007    5 PQDPYDDFDRERrvpeppksaglpteGQHRTDFARDRARVLHSAALRRLADKTQVVgPREGD-TPRTRLTHSLEVAQIGR 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570  76 SLGndvakAILERQPELessflpeigsiVSAACLAHDLGNPPFGHSGERAIStffsegkgqrlqekqpdgeqlspmEW-E 154
Cdd:PRK03007   84 GIA-----AGLGCDPDL-----------VDLAGLAHDIGHPPYGHNGERALD------------------------EVaA 123

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570 155 DLTHFEGNANAFRILThQFEGR------RRGGFVLTYSTLASIVKYPFSSSLAG--KKSKFGFFVSEEESY---RKIATE 223
Cdd:PRK03007  124 DCGGFEGNAQTLRILT-RLEPKvldpdgRSAGLNLTRASLDAACKYPWTRGEADgsPRRKFGFYDDDREVFawvRQGAPA 202

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 2176887570 224 lgliqlseqplkyARHPLvylvEA-----ADDICYQMMDIEDA 261
Cdd:PRK03007  203 -------------GRPCL----EAqvmdwADDVAYSVHDVEDG 228
HD_assoc pfam13286
Phosphohydrolase-associated domain; This domain is found on bacterial and archaeal ...
 358-441 1.41e-06

Phosphohydrolase-associated domain; This domain is found on bacterial and archaeal metal-dependent phosphohydrolases.


Pssm-ID: 433087 [Multi-domain]  Cd Length: 91  Bit Score: 46.37  E-value: 1.41e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176887570 358 KKIYRSQDVLDIELAGFRIISTLLE-LMVDAVTLPGkekAYSELLTNRVSDqynikspvlyERIQAVLDYISGMTDVFAL 436
Cdd:pfam13286  20 EYVYRHPRVQREEEKARRIIRELFEaLMADPELLPP---EFRARWEAAGDD----------ARARVVCDYIAGMTDRYAL 86


                  ....*
gi 2176887570 437 DLYRK 441
Cdd:pfam13286  87 RLHRR 91
HDc smart00471
Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic ...
 61-137 3.73e-03

Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic nucleotide phosphodiesterases (PDEc). This profile/HMM does not detect HD homologues in bacterial glycine aminoacyl-tRNA synthetases (beta subunit).


Pssm-ID: 214679 [Multi-domain]  Cd Length: 124  Bit Score: 37.28  E-value: 3.73e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2176887570   61 HNRLTHSLEVSCVGRSLgndvAKAILERQPELessflpeigsiVSAACLAHDLGNPPFGHSGERAISTFFSEGKGQR 137
Cdd:smart00471   3 YHVFEHSLRVAQLAAAL----AEELGLLDIEL-----------LLLAALLHDIGKPGTPDSFLVKTSVLEDHHFIGA 64
HD pfam01966
HD domain; HD domains are metal dependent phosphohydrolases.
 63-120 9.03e-03

HD domain; HD domains are metal dependent phosphohydrolases.


Pssm-ID: 460398 [Multi-domain]  Cd Length: 110  Bit Score: 36.06  E-value: 9.03e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2176887570  63 RLTHSLEVSCVGRSLGNDVAKAILERqpelessflpeigsiVSAACLAHDLGNPPFGH 120
Cdd:pfam01966   1 RLEHSLRVALLARELAEELGELDREL---------------LLLAALLHDIGKGPFGD 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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