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Conserved domains on  [gi|2183629315|ref|WP_235810543|]
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hypothetical protein [Legionella bozemanae]

Protein Classification

HNH endonuclease family protein( domain architecture ID 1640)

HNH endonuclease family protein, similar to Physarum polycephalum intron-encoded endonuclease I-Ppoi which mediates the mobility of intron 3 in the ribosomal DNA

EC:  3.1.-.-
Gene Ontology:  GO:0004519

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
HNHc super family cl00083
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic ...
1-48 2.30e-10

HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.


The actual alignment was detected with superfamily member PRK15137:

Pssm-ID: 469607  Cd Length: 235  Bit Score: 53.33  E-value: 2.30e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2183629315   1 MAEHYGLSLSSSQRQLFMVWNKTFPPSSWEKQWALHVAAIEGYENPYI 48
Cdd:PRK15137  179 MRDQYQLTLSRQQTQLFNAWDKQYPVTDWECERDERIAKVQGNHNPYV 226
 
Name Accession Description Interval E-value
PRK15137 PRK15137
DNA-specific endonuclease I; Provisional
1-48 2.30e-10

DNA-specific endonuclease I; Provisional


Pssm-ID: 185091  Cd Length: 235  Bit Score: 53.33  E-value: 2.30e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2183629315   1 MAEHYGLSLSSSQRQLFMVWNKTFPPSSWEKQWALHVAAIEGYENPYI 48
Cdd:PRK15137  179 MRDQYQLTLSRQQTQLFNAWDKQYPVTDWECERDERIAKVQGNHNPYV 226
Endonuclease_1 pfam04231
Endonuclease I; Bacterial periplasmic or secreted endonuclease I (EC:3.1.21.1) E. coli ...
1-48 2.29e-05

Endonuclease I; Bacterial periplasmic or secreted endonuclease I (EC:3.1.21.1) E. coli endonuclease I (EndoI) is a sequence independent endonuclease located in the periplasm. It is inhibited by different RNA species. It is thought to normally generate double strand breaks in DNA, except in the presence of high salt concentrations and RNA, when it generates single strand breaks in DNA. Its biological role is unknown. Other family members are known to be extracellular. This family also includes a non-specific, Mg2+ activated ribonuclease precursor.


Pssm-ID: 398077 [Multi-domain]  Cd Length: 235  Bit Score: 39.41  E-value: 2.29e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2183629315   1 MAEHYGLSLSSSQR-----------------QLFMVWNKTFPPSSWEKQWALHVAAIEGYENPYI 48
Cdd:pfam04231 167 MATRYELQISRWQSndmfdgtsdqvfsnwflNLLLAWHAQDPVSAKEIDRNNAIYGFQGNRNPFI 231
 
Name Accession Description Interval E-value
PRK15137 PRK15137
DNA-specific endonuclease I; Provisional
1-48 2.30e-10

DNA-specific endonuclease I; Provisional


Pssm-ID: 185091  Cd Length: 235  Bit Score: 53.33  E-value: 2.30e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2183629315   1 MAEHYGLSLSSSQRQLFMVWNKTFPPSSWEKQWALHVAAIEGYENPYI 48
Cdd:PRK15137  179 MRDQYQLTLSRQQTQLFNAWDKQYPVTDWECERDERIAKVQGNHNPYV 226
Endonuclease_1 pfam04231
Endonuclease I; Bacterial periplasmic or secreted endonuclease I (EC:3.1.21.1) E. coli ...
1-48 2.29e-05

Endonuclease I; Bacterial periplasmic or secreted endonuclease I (EC:3.1.21.1) E. coli endonuclease I (EndoI) is a sequence independent endonuclease located in the periplasm. It is inhibited by different RNA species. It is thought to normally generate double strand breaks in DNA, except in the presence of high salt concentrations and RNA, when it generates single strand breaks in DNA. Its biological role is unknown. Other family members are known to be extracellular. This family also includes a non-specific, Mg2+ activated ribonuclease precursor.


Pssm-ID: 398077 [Multi-domain]  Cd Length: 235  Bit Score: 39.41  E-value: 2.29e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2183629315   1 MAEHYGLSLSSSQR-----------------QLFMVWNKTFPPSSWEKQWALHVAAIEGYENPYI 48
Cdd:pfam04231 167 MATRYELQISRWQSndmfdgtsdqvfsnwflNLLLAWHAQDPVSAKEIDRNNAIYGFQGNRNPFI 231
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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