NCBI Conserved Domain Search

EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites ...

1107-2421

0e+00

EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism];

Pssm-ID: 440643 [Multi-domain] Cd Length: 1329 Bit Score: 1123.41 E-value: 0e+00

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1107 ARDASPQLSFAQERQWFIWRLDPHSAAYNIPVALRLKGPLRRDALQGALDLLVQRHETLRTTFVEHDGAPRQVIHPTLPI 1186
Cdd:COG1020     13 AAAAPLPLSAAQQRLWLLLLLLLGSAAYNLALALLLLGLLLVAALLLLAALLARRRRALRTRLRTRAGRPVQVIQPVVAA 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1187 AIEERRPPVAGEDLKG-----LVETEAHRPFDLQRGPLLRVLLLPLATDECVLVLTLHHIIADGWSMQVLVDELIRVYAA 1261
Cdd:COG1020     93 PLPVVVLLVDLEALAEaaaeaAAAAEALAPFDLLRGPLLRLLLLLLLLLLLLLLLALHHIISDGLSDGLLLAELLRLYLA 172

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1262 LRHDQPPALAELPIQYADFAAWQRQWMDGGERERQLDYWVSRLGGEQPLLELPSDRPRPQQQSHRGRRIGIPLPAELAEA 1341
Cdd:COG1020    173 AYAGAPLPLPPLPIQYADYALWQREWLQGEELARQLAYWRQQLAGLPPLLELPTDRPRPAVQSYRGARVSFRLPAELTAA 252

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1342 LRRLAQAEQGTLFMLLLASFQALLHRYSGQNDIRVGVPIANRNREETEGLIGFFVNTQVLRAELDGQLPFRELLRQVRQA 1421
Cdd:COG1020    253 LRALARRHGVTLFMVLLAAFALLLARYSGQDDVVVGTPVAGRPRPELEGLVGFFVNTLPLRVDLSGDPSFAELLARVRET 332

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1422 VVEAQGHQDLPFEQLVDALQPERSLSHAPLFQVMYNHQRDDHRGSRfasLGELEVEDLAWDVQTAQFDLTLDTYESSNGL 1501
Cdd:COG1020    333 LLAAYAHQDLPFERLVEELQPERDLSRNPLFQVMFVLQNAPADELE---LPGLTLEPLELDSGTAKFDLTLTVVETGDGL 409

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1502 LAELTYATDLFDASSAERIAGHWLNLLRSIVARPEARIAELKLLDEAEARADLLQWNPGPQDFTPASCLHRLIERQAAER 1581
Cdd:COG1020    410 RLTLEYNTDLFDAATIERMAGHLVTLLEALAADPDQPLGDLPLLTAAERQQLLAEWNATAAPYPADATLHELFEAQAART 489

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1582 PRATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGYMI 1661
Cdd:COG1020    490 PDAVAVVFGDQSLTYAELNARANRLAHHLRALGVGPGDLVGVCLERSLEMVVALLAVLKAGAAYVPLDPAYPAERLAYML 569

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1662 EDSGIRLLLTQRAARERLPlGEGLPCLLLDAEhEWAGYPESDPQSAVGVDNLAYVIYTSGSTGKPKGTLLPHGNVLRLFD 1741
Cdd:COG1020    570 EDAGARLVLTQSALAARLP-ELGVPVLALDAL-ALAAEPATNPPVPVTPDDLAYVIYTSGSTGRPKGVMVEHRALVNLLA 647

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1742 ATRHWFGFSADDAWSLFHSYAFDFSVWEIFGALLHGGRLVIVPYETSRSPEDFLRLLCRERVTVLNQTPSAFKQLMQVAC 1821
Cdd:COG1020    648 WMQRRYGLGPGDRVLQFASLSFDASVWEIFGALLSGATLVLAPPEARRDPAALAELLARHRVTVLNLTPSLLRALLDAAP 727

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1822 AGqevpPLALRHVVFGGEALEVQALRPWFERFGDRapRLVNMYGITETTVHVTYRPLSLADLDGGaASPIGEPIPDLSWY 1901
Cdd:COG1020    728 EA----LPSLRLVLVGGEALPPELVRRWRARLPGA--RLVNLYGPTETTVDSTYYEVTPPDADGG-SVPIGRPIANTRVY 800

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1902 LLDAGLNPVPRGCIGELYVGGAGLARGYLNRPELSCTRFVADPFSTTGGRLYRTGDLARYRCDGVVEYVGRIDHQVKIRG 1981
Cdd:COG1020    801 VLDAHLQPVPVGVPGELYIGGAGLARGYLNRPELTAERFVADPFGFPGARLYRTGDLARWLPDGNLEFLGRADDQVKIRG 880

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1982 FRIELGEIEARLLAQPGVAEAVVLPHE-GPGATQLVGYVVTQAAPSDPAALRdtlRQALKASLPEHMVPAHLLFLERLPL 2060
Cdd:COG1020    881 FRIELGEIEAALLQHPGVREAVVVAREdAPGDKRLVAYVVPEAGAAAAAALL---RLALALLLPPYMVPAAVVLLLPLPL 957

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2061 TANGKLDRRALPAPDASRLQRDYTAPRSELEQRLAAIWADVLKLGRVGLDDNFFELGGDSIISIQVVSRARQAGIRLAPR 2140
Cdd:COG1020    958 TGNGKLDRLALPAPAAAAAAAAAAPPAEEEEEEAALALLLLLVVVVGDDDFFFFGGGLGLLLLLALARAARLLLLLLLLL 1037

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2141 DLFLHQTIRGLAGVAVEGRGLACAEQGPISGSTPLLPIQQMFFELDIPRRQHWNQSVLLEPGQALDGTLLETALQALLAH 2220
Cdd:COG1020   1038 LLFLAAAAAAAAAAAAAAAAAAAAPLAAAAAPLPLPPLLLSLLALLLALLLLLALLALLALLLLLLLLLLLLALLLLLAL 1117

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2221 HDALRLGFRLEDGTWRAEHRAVEAGEVLLWQ-------QSVADGQALEALAEQVQRSLDLGSGPLLRALLATLGDGSQRL 2293
Cdd:COG1020   1118 LLALLAALRARRAVRQEGPRLRLLVALAAALalaallaLLLAAAAAAAELLAAAALLLLLALLLLALLLLLLLLLLLLLL 1197

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2294 LLVIHHLVVDGVSWRILLEDLQTAYRQLQAGQAVALPAKTSAFKAWAERLQAHARDGGLEGERGYWLAQLEGVSTELPCD 2373
Cdd:COG1020   1198 LLLLLLLLLLLLLLLLLLLLLLLLLLLAAAAAALLALALLLALLALAALLALAALAALAAALLALALALLALALLLLALA 1277

                         1290      1300      1310      1320
                   ....*....|....*....|....*....|....*....|....*...
gi 2183974163 2374 DREGAQSVRHVRSARTELTEEATRRLLQEAPAAYRTQVNDLLLTALAR 2421
Cdd:COG1020   1278 LLLPALARARAARTARALALLLLLALLLLLALALALLLLLLLLLALLL 1325

A_NRPS_Cytc1-like

similar to adenylation domain of cytotrienin synthetase CytC1; This family of the adenylation ...

1582-2071

0e+00

similar to adenylation domain of cytotrienin synthetase CytC1; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes Streptomyces sp. cytotrienin synthetase (CytC1), a relatively promiscuous adenylation enzyme that installs the aminoacyl moieties on the phosphopantetheinyl arm of the holo carrier protein CytC2. Also included are Streptomyces sp Thr1, involved in the biosynthesis of 4-chlorothreonine, Pseudomonas aeruginosa pyoverdine synthetase D (PvdD), involved in the biosynthesis of the siderophore pyoverdine and Pseudomonas syringae syringopeptin synthetase, where syringpeptin is a necrosis-inducing phytotoxin that functions as a virulence determinant in the plant-pathogen interaction. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.

Pssm-ID: 341298 [Multi-domain] Cd Length: 450 Bit Score: 719.86 E-value: 0e+00

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1582 PRATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGYMI 1661
Cdd:cd17643      1 PEAVAVVDEDRRLTYGELDARANRLARTLRAEGVGPGDRVALALPRSAELIVALLAILKAGGAYVPIDPAYPVERIAFIL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1662 EDSGIRLLLTQraarerlplgeglpcllldaehewagypesdpqsavgVDNLAYVIYTSGSTGKPKGTLLPHGNVLRLFD 1741
Cdd:cd17643     81 ADSGPSLLLTD-------------------------------------PDDLAYVIYTSGSTGRPKGVVVSHANVLALFA 123

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1742 ATRHWFGFSADDAWSLFHSYAFDFSVWEIFGALLHGGRLVIVPYETSRSPEDFLRLLCRERVTVLNQTPSAFKQLMQVAC 1821
Cdd:cd17643    124 ATQRWFGFNEDDVWTLFHSYAFDFSVWEIWGALLHGGRLVVVPYEVARSPEDFARLLRDEGVTVLNQTPSAFYQLVEAAD 203

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1822 AGQEvPPLALRHVVFGGEALEVQALRPWFERFGDRAPRLVNMYGITETTVHVTYRPLSLADLDGGAASPIGEPIPDLSWY 1901
Cdd:cd17643    204 RDGR-DPLALRYVIFGGEALEAAMLRPWAGRFGLDRPQLVNMYGITETTVHVTFRPLDAADLPAAAASPIGRPLPGLRVY 282

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1902 LLDAGLNPVPRGCIGELYVGGAGLARGYLNRPELSCTRFVADPFSTTGGRLYRTGDLARYRCDGVVEYVGRIDHQVKIRG 1981
Cdd:cd17643    283 VLDADGRPVPPGVVGELYVSGAGVARGYLGRPELTAERFVANPFGGPGSRMYRTGDLARRLPDGELEYLGRADEQVKIRG 362

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1982 FRIELGEIEARLLAQPGVAEAVVLPHEG-PGATQLVGYVVTQAAPSDPAAlrdTLRQALKASLPEHMVPAHLLFLERLPL 2060
Cdd:cd17643    363 FRIELGEIEAALATHPSVRDAAVIVREDePGDTRLVAYVVADDGAAADIA---ELRALLKELLPDYMVPARYVPLDALPL 439

                          490
                   ....*....|.
gi 2183974163 2061 TANGKLDRRAL 2071
Cdd:cd17643    440 TVNGKLDRAAL 450

AA-adenyl-dom

amino acid adenylation domain; This model represents a domain responsible for the specific ...

1596-2004

9.09e-166

amino acid adenylation domain; This model represents a domain responsible for the specific recognition of amino acids and activation as adenylyl amino acids. The reaction catalyzed is aa + ATP -> aa-AMP + PPi. These domains are usually found as components of multi-domain non-ribosomal peptide synthetases and are usually called "A-domains" in that context. A-domains are almost invariably followed by "T-domains" (thiolation domains, pfam00550) to which the amino acid adenylate is transferred as a thiol-ester to a bound pantetheine cofactor with the release of AMP (these are also called peptide carrier proteins, or PCPs. When the A-domain does not represent the first module (corresponding to the first amino acid in the product molecule) it is usually preceded by a "C-domain" (condensation domain, pfam00668) which catalyzes the ligation of two amino acid thiol-esters from neighboring modules. This domain is a subset of the AMP-binding domain found in Pfam (pfam00501) which also hits substrate--CoA ligases and luciferases. Sequences scoring in between trusted and noise for this model may be ambiguous as to whether they activate amino acids or other molecules lacking an alpha amino group.

Pssm-ID: 273779 [Multi-domain] Cd Length: 409 Bit Score: 517.97 E-value: 9.09e-166

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1596 YGELNLRANRLAHRLIEL-GVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGYMIEDSGIRLLLTQRA 1674
Cdd:TIGR01733    2 YRELDERANRLARHLRAAgGVGPGDRVAVLLERSAELVVAILAVLKAGAAYVPLDPAYPAERLAFILEDAGARLLLTDSA 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1675 ARERLPlGEGLPCLLLDAEHEWAGYPESD---PQSAVGVDNLAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRHWFGFSA 1751
Cdd:TIGR01733   82 LASRLA-GLVLPVILLDPLELAALDDAPApppPDAPSGPDDLAYVIYTSGSTGRPKGVVVTHRSLVNLLAWLARRYGLDP 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1752 DDAWSLFHSYAFDFSVWEIFGALLHGGRLVIVPYETSRSPEDFLRLLCRER-VTVLNQTPSAFKQLMQVACAgqevPPLA 1830
Cdd:TIGR01733  161 DDRVLQFASLSFDASVEEIFGALLAGATLVVPPEDEERDDAALLAALIAEHpVTVLNLTPSLLALLAAALPP----ALAS 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1831 LRHVVFGGEALEVQALRPWFERFGDRapRLVNMYGITETTVHVTYRPLSLADLDGGAASPIGEPIPDLSWYLLDAGLNPV 1910
Cdd:TIGR01733  237 LRLVILGGEALTPALVDRWRARGPGA--RLINLYGPTETTVWSTATLVDPDDAPRESPVPIGRPLANTRLYVLDDDLRPV 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1911 PRGCIGELYVGGAGLARGYLNRPELSCTRFVADPFSTT-GGRLYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEI 1989
Cdd:TIGR01733  315 PVGVVGELYIGGPGVARGYLNRPELTAERFVPDPFAGGdGARLYRTGDLVRYLPDGNLEFLGRIDDQVKIRGYRIELGEI 394

                          410
                   ....*....|....*
gi 2183974163 1990 EARLLAQPGVAEAVV 2004
Cdd:TIGR01733  395 EAALLRHPGVREAVV 409

AMP-binding

AMP-binding enzyme;

1574-1980

1.80e-116

AMP-binding enzyme;

Pssm-ID: 459834 [Multi-domain] Cd Length: 417 Bit Score: 376.65 E-value: 1.80e-116

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1574 IERQAAERPRATAVVYGE-RALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRY 1652
Cdd:pfam00501    1 LERQAARTPDKTALEVGEgRRLTYRELDERANRLAAGLRALGVGKGDRVAILLPNSPEWVVAFLACLKAGAVYVPLNPRL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1653 PSDRLGYMIEDSGIRLLLTQ--------RAARERLPLG------EGLPCLLLDAEHEWAGYPESDPQSAVGV--DNLAYV 1716
Cdd:pfam00501   81 PAEELAYILEDSGAKVLITDdalkleelLEALGKLEVVklvlvlDRDPVLKEEPLPEEAKPADVPPPPPPPPdpDDLAYI 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1717 IYTSGSTGKPKGTLLPHGNVLR----LFDATRHWFGFSADDAWSLFHSYAFDFSV-WEIFGALLHGGRLVIVPYETSRSP 1791
Cdd:pfam00501  161 IYTSGTTGKPKGVMLTHRNLVAnvlsIKRVRPRGFGLGPDDRVLSTLPLFHDFGLsLGLLGPLLAGATVVLPPGFPALDP 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1792 EDFLRLLCRERVTVLNQTPSAFKQLMQVACAGQEVPPlALRHVVFGGEALEVQALRPWFERFGdraPRLVNMYGITETTV 1871
Cdd:pfam00501  241 AALLELIERYKVTVLYGVPTLLNMLLEAGAPKRALLS-SLRLVLSGGAPLPPELARRFRELFG---GALVNGYGLTETTG 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1872 HVTYRPlsLADLDGGAASPIGEPIPDLSWYLLD-AGLNPVPRGCIGELYVGGAGLARGYLNRPELSCTRFVADpfsttgg 1950
Cdd:pfam00501  317 VVTTPL--PLDEDLRSLGSVGRPLPGTEVKIVDdETGEPVPPGEPGELCVRGPGVMKGYLNDPELTAEAFDED------- 387

                          410       420       430
                   ....*....|....*....|....*....|
gi 2183974163 1951 RLYRTGDLARYRCDGVVEYVGRIDHQVKIR 1980
Cdd:pfam00501  388 GWYRTGDLGRRDEDGYLEIVGRKKDQIKLG 417

PKS_PP

smart00823

Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the ...

2087-2153

9.28e-06

Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the prosthetic group of acyl carrier proteins (ACP) in some multienzyme complexes where it serves as a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups.

Pssm-ID: 214834 [Multi-domain] Cd Length: 86 Bit Score: 46.09 E-value: 9.28e-06

                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2183974163  2087 RSELEQRLAAIWADVLKLG---RVGLDDNFFELGGDSIISIQVVSRARQA-GIRLAPRDLFLHQTIRGLAG 2153
Cdd:smart00823   10 RRLLLDLVREQVAAVLGHAaaeAIDPDRPFRDLGLDSLMAVELRNRLEAAtGLRLPATLVFDHPTPAALAE 80

Name

Accession

Description

Interval

E-value

PRK12467

peptide synthase; Provisional

1-3183

0e+00

peptide synthase; Provisional

Pssm-ID: 237108 [Multi-domain] Cd Length: 3956 Bit Score: 5314.68 E-value: 0e+00

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163    1 MSVALRVARRFITLPLDKRMLYLAKMQEEGVTPANLPIPEVASAFERIPLSYAQERQWFLWQMDPQSAAYNIPSALRLRG 80
Cdd:PRK12467     3 NNVALRIARRFITLPLEKRRLYLEKMQEEGVSFANLPIPQVRSAFERIPLSYAQERQWFLWQLDPDSAAYNIPTALRLRG 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163   81 ELDVEALSASLGAIVERHQSLRTVFVEDEqlDGFRQQVLASVDVPVPVTLAGD---DDAQAQIRAFVESETQQPFDLRNG 157
Cdd:PRK12467    83 ELDVSALRRAFDALVARHESLRTRFVQDE--EGFRQVIDASLSLTIPLDDLANeqgRARESQIEAYINEEVARPFDLANG 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  158 PLLRARLLRLAADDHVLTLTIHHVAADGWSMRVLVEELIALYGARRQGIEATLPDLPIQYADYAIWQRHWLEAGERERQL 237
Cdd:PRK12467   161 PLLRVRLLRLADDEHVLVVTLHHIISDGWSMRVLVEELVQLYSAYSQGREPSLPALPIQYADYAIWQRSWLEAGERERQL 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  238 EYWMARLGGGQSVLELPTDRQRPALPSYRGARHELQLPQALGRQLQALAQREGTTLFMLLLASFQALLHRYSGQDEIRVG 317
Cdd:PRK12467   241 AYWQEQLGGEHTVLELPTDRPRPAVPSYRGARLRVDLPQALSAGLKALAQREGVTLFMVLLASFQTLLHRYSGQSDIRIG 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  318 VPVANRNRVETERLIGFFVNTQVLRADLDAQMPFLDLLQQTRVAALGAQSHQDLPFEQLVEALQPERSLSHSPLFQAMYN 397
Cdd:PRK12467   321 VPNANRNRVETERLIGFFVNTQVLKAEVDPQASFLELLQQVKRTALGAQAHQDLPFEQLVEALQPERSLSHSPLFQVMFN 400

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  398 HQNLGSAGRQSLAAQLPGLSVEDLSWGAHSAQFDLTLDTYESEQGVHAEFTYATDLFEAATVERLARHWRNLLEAVVAEP 477
Cdd:PRK12467   401 HQNTATGGRDREGAQLPGLTVEELSWARHTAQFDLALDTYESAQGLWAAFTYATDLFEATTIERLATHWRNLLEAIVAEP 480

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  478 RRRLGDLPLLDAEERATLLQRSRLPASEYpAGQGVHRLFEAQAGLTPDAPALLFGEERLSYAELNALANRLAWRLREEGV 557
Cdd:PRK12467   481 RRRLGELPLLDAEERARELVRWNAPATEY-APDCVHQLIEAQARQHPERPALVFGEQVLSYAELNRQANRLAHVLIAAGV 559

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  558 GSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQYMIDDSGLRLLLSQQSVLARLPQSDGLQSLLLDDLER 637
Cdd:PRK12467   560 GPDVLVGIAVERSIEMVVGLLAVLKAGGAYVPLDPEYPQDRLAYMLDDSGVRLLLTQSHLLAQLPVPAGLRSLCLDEPAD 639

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  638 LVHGYPAENPDLPEAPDSLCYAIYTSGSTGQPKGVMVRHRALTNFVCSIARQPGMLARDRLLSVTTFSFDIFGLELYVPL 717
Cdd:PRK12467   640 LLCGYSGHNPEVALDPDNLAYVIYTSGSTGQPKGVAISHGALANYVCVIAERLQLAADDSMLMVSTFAFDLGVTELFGAL 719

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  718 ARGASMLLASREQAQDPEALLDLVERQGVTVLQATPATWRMLCDSERVDLLRGCT-LLCGGEALAEDLAARMR--GLSAS 794
Cdd:PRK12467   720 ASGATLHLLPPDCARDAEAFAALMADQGVTVLKIVPSHLQALLQASRVALPRPQRaLVCGGEALQVDLLARVRalGPGAR 799

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  795 TWNLYGPTETTIWSARFRLGEEARPF----LGGPLENTALYILDSEMNPCPPGVAGELLIGGDGLARGYHRRPGLTAERF 870
Cdd:PRK12467   800 LINHYGPTETTVGVSTYELSDEERDFgnvpIGQPLANLGLYILDHYLNPVPVGVVGELYIGGAGLARGYHRRPALTAERF 879

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  871 LPDPFAADGSRLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQPGVAGPTLVAYLV 950
Cdd:PRK12467   880 VPDPFGADGGRLYRTGDLARYRADGVIEYLGRMDHQVKIRGFRIELGEIEARLLAQPGVREAVVLAQPGDAGLQLVAYLV 959

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  951 PTeaalVDAESARQQELRSALKNSLLAVLPDYMVPAHMLLLENLPLTPNGKINRKALPLPDASAVRDAHVAPEGELERAM 1030
Cdd:PRK12467   960 PA----AVADGAEHQATRDELKAQLRQVLPDYMVPAHLLLLDSLPLTPNGKLDRKALPKPDASAVQATFVAPQTELEKRL 1035

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1031 AAIWSEVLKLGHIGRDDNFFELGGHSLLVTQVVSRVRRRLDLQVPLRTLFEHSTLRAYAQAVAQLAPAAQGGIVRCARDA 1110
Cdd:PRK12467  1036 AAIWADVLKVERVGLTDNFFELGGHSLLATQVISRVRQRLGIQVPLRTLFEHQTLAGFAQAVAAQQQGAQPALPDVDRDQ 1115

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1111 SPQLSFAQERQWFIWRLDPHSAAYNIPVALRLKGPLRRDALQGALDLLVQRHETLRTTFVEHDGAPRQVIHPTLPIAIEE 1190
Cdd:PRK12467  1116 PLPLSYAQERQWFLWQLEPGSAAYHIPQALRLKGPLDIEALERSFDALVARHESLRTTFVQEDGRTRQVIHPVGSLTLEE 1195

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1191 RRPPVAGED---LKGLVETEAHRPFDLQRGPLLRVLLLPLATDECVLVLTLHHIIADGWSMQVLVDELIRVYAALRHDQP 1267
Cdd:PRK12467  1196 PLLLAADKDeaqLKVYVEAEARQPFDLEQGPLLRVGLLRLAADEHVLVLTLHHIVSDGWSMQVLVDELVALYAAYSQGQS 1275

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1268 PALAELPIQYADFAAWQRQWMDGGERERQLDYWVSRLGGEQPLLELPSDRPRPQQQSHRGRRIGIPLPAELAEALRRLAQ 1347
Cdd:PRK12467  1276 LQLPALPIQYADYAVWQRQWMDAGERARQLAYWKAQLGGEQPVLELPTDRPRPAVQSHRGARLAFELPPALAEGLRALAR 1355

                         1370      1380      1390      1400      1410      1420      1430      1440
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1348 AEQGTLFMLLLASFQALLHRYSGQNDIRVGVPIANRNREETEGLIGFFVNTQVLRAELDGQLPFRELLRQVRQAVVEAQG 1427
Cdd:PRK12467  1356 REGVTLFMLLLASFQTLLHRYSGQDDIRVGVPIANRNRAETEGLIGFFVNTQVLRAEVDGQASFQQLLQQVKQAALEAQA 1435

                         1450      1460      1470      1480      1490      1500      1510      1520
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1428 HQDLPFEQLVDALQPERSLSHAPLFQVMYNHQRDDHRGSrfASLGELEVEDLAWDVQTAQFDLTLDTYESSNGLLAELTY 1507
Cdd:PRK12467  1436 HQDLPFEQLVEALQPERSLSHSPLFQVMFNHQRDDHQAQ--AQLPGLSVESLSWESQTAQFDLTLDTYESSEGLQASLTY 1513

                         1530      1540      1550      1560      1570      1580      1590      1600
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1508 ATDLFDASSAERIAGHWLNLLRSIVARPEARIAELKLLDEAEARADLLQWNPGPQDFTPASCLHRLIERQAAERPRATAV 1587
Cdd:PRK12467  1514 ATDLFEASTIERLAGHWLNLLQGLVADPERRLGELDLLDEAERRQILEGWNATHTGYPLARLVHQLIEDQAAATPEAVAL 1593

                         1610      1620      1630      1640      1650      1660      1670      1680
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1588 VYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGYMIEDSGIR 1667
Cdd:PRK12467  1594 VFGEQELTYGELNRRANRLAHRLIALGVGPEVLVGIAVERSLEMVVGLLAILKAGGAYVPLDPEYPRERLAYMIEDSGIE 1673

                         1690      1700      1710      1720      1730      1740      1750      1760
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1668 LLLTQRAARERLPLGEGLPCLLLDAEHEW-AGYPESDPQSAVGVDNLAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRHW 1746
Cdd:PRK12467  1674 LLLTQSHLQARLPLPDGLRSLVLDQEDDWlEGYSDSNPAVNLAPQNLAYVIYTSGSTGRPKGAGNRHGALVNRLCATQEA 1753

                         1770      1780      1790      1800      1810      1820      1830      1840
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1747 FGFSADDAWSLFHSYAFDFSVWEIFGALLHGGRLVIVPYETSRSPEDFLRLLCRERVTVLNQTPSAFKQLMQVAcaGQEV 1826
Cdd:PRK12467  1754 YQLSAADVVLQFTSFAFDVSVWELFWPLINGARLVIAPPGAHRDPEQLIQLIERQQVTTLHFVPSMLQQLLQMD--EQVE 1831

                         1850      1860      1870      1880      1890      1900      1910      1920
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1827 PPLALRHVVFGGEALEVQALRPWFERFGDRAprLVNMYGITETTVHVTYRPLSLADLDGGAASPIGEPIPDLSWYLLDAG 1906
Cdd:PRK12467  1832 HPLSLRRVVCGGEALEVEALRPWLERLPDTG--LFNLYGPTETAVDVTHWTCRRKDLEGRDSVPIGQPIANLSTYILDAS 1909

                         1930      1940      1950      1960      1970      1980      1990      2000
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1907 LNPVPRGCIGELYVGGAGLARGYLNRPELSCTRFVADPFSTTGGRLYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIEL 1986
Cdd:PRK12467  1910 LNPVPIGVAGELYLGGVGLARGYLNRPALTAERFVADPFGTVGSRLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIEL 1989

                         2010      2020      2030      2040      2050      2060      2070      2080
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1987 GEIEARLLAQPGVAEAVVLPHEGPGATQLVGYVVTQAAP-----SDPAALRDTLRQALKASLPEHMVPAHLLFLERLPLT 2061
Cdd:PRK12467  1990 GEIEARLREQGGVREAVVIAQDGANGKQLVAYVVPTDPGlvdddEAQVALRAILKNHLKASLPEYMVPAHLVFLARMPLT 2069

                         2090      2100      2110      2120      2130      2140      2150      2160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2062 ANGKLDRRALPAPDASRLQRDYTAPRSELEQRLAAIWADVLKLGRVGLDDNFFELGGDSIISIQVVSRARQAGIRLAPRD 2141
Cdd:PRK12467  2070 PNGKLDRKALPAPDASELQQAYVAPQSELEQRLAAIWQDVLGLEQVGLHDNFFELGGDSIISIQVVSRARQAGIRFTPKD 2149

                         2170      2180      2190      2200      2210      2220      2230      2240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2142 LFLHQTIRGLAGVAVEGRGLACAEQGPISGSTPLLPIQQMFFELDIPRRQHWNQSVLLEPGQALDGTLLETALQALLAHH 2221
Cdd:PRK12467  2150 LFQHQTVQSLAAVAQEGDGTVSIDQGPVTGDLPLLPIQQMFFADDIPERHHWNQSVLLEPREALDAELLEAALQALLVHH 2229

                         2250      2260      2270      2280      2290      2300      2310      2320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2222 DALRLGFRLEDGTWRAEHRA-VEAGEVLLWQQSVADGQALEALAEQVQRSLDLGSGPLLRALLATLGDGSQRLLLVIHHL 2300
Cdd:PRK12467  2230 DALRLGFVQEDGGWSAMHRApEQERRPLLWQVVVADKEELEALCEQAQRSLDLEEGPLLRAVLATLPDGSQRLLLVIHHL 2309

                         2330      2340      2350      2360      2370      2380      2390      2400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2301 VVDGVSWRILLEDLQTAYRQLQAGQAVALPAKTSAFKAWAERLQAHARDGGLEGERGYWLAQLEGVSTELPCDDREGAQS 2380
Cdd:PRK12467  2310 VVDGVSWRILLEDLQTAYRQLQGGQPVKLPAKTSAFKAWAERLQTYAASAALADELGYWQAQLQGASTELPCDHPQGGLQ 2389

                         2410      2420      2430      2440      2450      2460      2470      2480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2381 VRHVRSARTELTEEATRRLLQEAPAAYRTQVNDLLLTALARVIGRWTGQADTLIQLEGHGREELFEDIDLTRTVGWFTSL 2460
Cdd:PRK12467  2390 RRHAASVTTHLDSEWTRRLLQEAPAAYRTQVNDLLLTALARVIARWTGQASTLIQLEGHGREDLFDEIDLTRTVGWFTSL 2469

                         2490      2500      2510      2520      2530      2540      2550      2560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2461 FPLRLSPVAELGASIKRIKEQLRAIPHKGLGFGALRYLGSAEDRAALAALPSPRITFNYLGQFDGSFSADSSALFRPSAD 2540
Cdd:PRK12467  2470 YPVKLSPTASLATSIKTIKEQLRAVPNKGLGFGVLRYLGSEAARQTLQALPVPRITFNYLGQFDGSFDAEKQALFVPSGE 2549

                         2570      2580      2590      2600      2610      2620      2630      2640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2541 AAGSERDSDAPLDNWLSLNGQVYAGRLGIDWSFSAARFSEASILRLADAYRDELLALIEHCCAADVEGVTPSDFPLAGLD 2620
Cdd:PRK12467  2550 FSGAEQSEEAPLGNWLSINGQVYGGELNLGWTFSQEMFDEATIQRLADAYAEELRALIEHCCSNDQRGVTPSDFPLAGLS 2629

                         2650      2660      2670      2680      2690      2700      2710      2720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2621 QRQLDALPLAAGEVEDLYPLSPMQQGMLFHSLYQQNSGDYINQMRLDVEGLDPQRFREAWQAALDAHEVLRSGFLWQGAL 2700
Cdd:PRK12467  2630 QEQLDRLPVAVGDIEDIYPLSPMQQGMLFHTLYEGGAGDYINQMRVDVEGLDVERFRTAWQAVIDRHEILRSGFLWDGEL 2709

                         2730      2740      2750      2760      2770      2780      2790      2800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2701 EKPLQLVRKRVEVPFSVHDWRDRADLAEALDALAAGEAGLGFELAEAPLLRLVLVRTGERRHHLIYTNHHILMDGWSNSQ 2780
Cdd:PRK12467  2710 EEPLQVVYKQARLPFSRLDWRDRADLEQALDALAAADRQQGFDLLSAPLLRLTLVRTGEDRHHLIYTNHHILMDGWSGSQ 2789

                         2810      2820      2830      2840      2850      2860      2870      2880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2781 LLGEVLQRYRGETPSRSDGRYRDYIAWLQRQDAGRTEAFWKQRLQRLGEPTLLVPAF-AHGVRGAEGHADRYRQLDVTTS 2859
Cdd:PRK12467  2790 LLGEVLQRYFGQPPPAREGRYRDYIAWLQAQDAEASEAFWKEQLAALEEPTRLARALyPAPAEAVAGHGAHYLHLDATQT 2869

                         2890      2900      2910      2920      2930      2940      2950      2960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2860 QRLAEFAREQKVTLNTLVQAAWLILLQRFTGQDTVAFGATVSGRPAELRGIEEQIGLFINTLPVVASPCPEQPIGDWLQA 2939
Cdd:PRK12467  2870 RQLIEFARRHRVTLNTLVQGAWLLLLQRFTGQDTVCFGATVAGRPAQLRGAEQQLGLFINTLPVIASPRAEQTVSDWLQQ 2949

                         2970      2980      2990      3000      3010      3020      3030      3040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2940 VQGENLALREFEHTPLYDIQRWAGQVGEALFDNILVFENYPVSAALAEETPADMRIDALSNQEQTHYPLTLLVSAGETLE 3019
Cdd:PRK12467  2950 VQAQNLALREFEHTPLADIQRWAGQGGEALFDSILVFENYPISEALKQGAPSGLRFGAVSSREQTNYPLTLAVGLGDTLE 3029

                         3050      3060      3070      3080      3090      3100      3110      3120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3020 LHYSYSRQAFDEAAIECLAERLERLLLGMCENPGASLGELDSLAVAERYQLLEGWNATAAEYPLQRGVHRLFEEQVERTP 3099
Cdd:PRK12467  3030 LEFSYDRQHFDAAAIERLAESFDRLLQAMLNNPAARLGELPTLAAHERRQVLHAWNATAAAYPSERLVHQLIEAQVARTP 3109

                         3130      3140      3150      3160      3170      3180      3190      3200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3100 TAPALAFGEERLDYAELNRRANRLAHALIERGIGADRLVGVAMERSIEMVVALMAILKAGGAYVPVDPEYPEERQAYMLE 3179
Cdd:PRK12467  3110 EAPALVFGDQQLSYAELNRRANRLAHRLIAIGVGPDVLVGVAVERSVEMIVALLAVLKAGGAYVPLDPEYPRERLAYMIE 3189


                   ....
gi 2183974163 3180 DSGV 3183
Cdd:PRK12467  3190 DSGV 3193

PRK12316

peptide synthase; Provisional

23-3183

0e+00

peptide synthase; Provisional

Pssm-ID: 237054 [Multi-domain] Cd Length: 5163 Bit Score: 3384.63 E-value: 0e+00

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163   23 LAKMQEEGVTPANLPIPEVASAFeriPLSYAQERQWFLWQMDPQSAAYniPSALRLRGE-LDVEALSASLGAIVERHQSL 101
Cdd:PRK12316  1535 LAGLSQAQLDALPLPAGEIADIY---PLSPMQQGMLFHSLYEQEAGDY--INQLRVDVQgLDPDRFRAAWQATVDRHEIL 1609

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  102 RTVFVEDEQLDGFRQQVLASVDVPVPV-TLAGDDDAQAQIRAFVESETQQPFDLRNGPLLRARLLRLAADDHVLTLTIHH 180
Cdd:PRK12316  1610 RSGFLWQDGLEQPLQVIHKQVELPFAElDWRGREDLGQALDALAQAERQKGFDLTRAPLLRLVLVRTGEGRHHLIYTNHH 1689

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  181 VAADGWSMRVLVEELIALYGARrqgieaTLPDLPIQYADYAIW-QRHWLEAGERerqleYWMARLGGgqsvLELPT---D 256
Cdd:PRK12316  1690 ILMDGWSNAQLLGEVLQRYAGQ------PVAAPGGRYRDYIAWlQRQDAAASEA-----FWKEQLAA----LEEPTrlaQ 1754

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  257 RQRPALPSYRGARHELQLPQALGRQLQALAQREGTTLFMLLLASFQALLHRYSGQDEIRVGVPVANR--NRVETERLIGF 334
Cdd:PRK12316  1755 AARTEDGQVGYGDHQQLLDPAQTRALAEFARAQKVTLNTLVQAAWLLLLQRYTGQETVAFGATVAGRpaELPGIEQQIGL 1834

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  335 FVNTQVLRADLDAQMPFLDLLQQTRVAALGAQSHQDLPFEQLvealQPERSLSHSPLFQAMYNHQNLGSAgrQSLAAQLP 414
Cdd:PRK12316  1835 FINTLPVIAAPRPDQSVADWLQEVQALNLALREHEHTPLYDI----QRWAGQGGEALFDSLLVFENYPVA--EALKQGAP 1908

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  415 -GLSVEDLSwGAHSAQFDLTLDTYESEQgVHAEFTYATDLFEAATVERLARHWRNLLEAVVAEPRRRLGDLPLLDAEERA 493
Cdd:PRK12316  1909 aGLVFGRVS-NHEQTNYPLTLAVTLGET-LSLQYSYDRGHFDAAAIERLDRHLLHLLEQMAEDAQAALGELALLDAGERQ 1986

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  494 TLLQRSRLPASEYPAGQGVHRLFEAQAGLTPDAPALLFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPM 573
Cdd:PRK12316  1987 RILADWDRTPEAYPRGPGVHQRIAEQAARAPEAIAVVFGDQHLSYAELDSRANRLAHRLRARGVGPEVRVAIAAERSFEL 2066

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  574 VVALLAVLKAGGAYVPLDPQYPADRLQYMIDDSGLRLLLSQQSVLARLPQSDGLQSLLLDDLERLvHGYPAENPDLPEAP 653
Cdd:PRK12316  2067 VVALLAVLKAGGAYVPLDPNYPAERLAYMLEDSGAALLLTQRHLLERLPLPAGVARLPLDRDAEW-ADYPDTAPAVQLAG 2145

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  654 DSLCYAIYTSGSTGQPKGVMVRHRALTNFVCSIARQPGMLARDRLLSVTTFSFDIFGLELYVPLARGASMLLASREQaQD 733
Cdd:PRK12316  2146 ENLAYVIYTSGSTGLPKGVAVSHGALVAHCQAAGERYELSPADCELQFMSFSFDGAHEQWFHPLLNGARVLIRDDEL-WD 2224

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  734 PEALLDLVERQGVTVLQATPATWRMLCDSERVDllrGCTL-----LCGGEAL-AEDLAARMRGLSASTW-NLYGPTETTI 806
Cdd:PRK12316  2225 PEQLYDEMERHGVTILDFPPVYLQQLAEHAERD---GRPPavrvyCFGGEAVpAASLRLAWEALRPVYLfNGYGPTEAVV 2301

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  807 ----WSARFRLGEEAR-PFLGGPLENTALYILDSEMNPCPPGVAGELLIGGDGLARGYHRRPGLTAERFLPDPFAADGSR 881
Cdd:PRK12316  2302 tpllWKCRPQDPCGAAyVPIGRALGNRRAYILDADLNLLAPGMAGELYLGGEGLARGYLNRPGLTAERFVPDPFSASGER 2381

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  882 LYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQPGVAGPTLVAYLVPTEAalvdaes 961
Cdd:PRK12316  2382 LYRTGDLARYRADGVVEYLGRIDHQVKIRGFRIELGEIEARLQAHPAVREAVVVAQDGASGKQLVAYVVPDDA------- 2454

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  962 arQQELRSALKNSLLAVLPDYMVPAHMLLLENLPLTPNGKINRKALPLPDASAVRDAHVAPEGELERAMAAIWSEVLKLG 1041
Cdd:PRK12316  2455 --AEDLLAELRAWLAARLPAYMVPAHWVVLERLPLNPNGKLDRKALPKPDVSQLRQAYVAPQEGLEQRLAAIWQAVLKVE 2532

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1042 HIGRDDNFFELGGHSLLVTQVVSRVRRRLDLQVPLRTLFEHSTLRAYAQAVAQLAPAAQGGIVRCARDASPQLSFAQERQ 1121
Cdd:PRK12316  2533 QVGLDDHFFELGGHSLLATQVVSRVRQDLGLEVPLRILFERPTLAAFAASLESGQTSRAPVLQKVTRVQPLPLSHAQQRQ 2612

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1122 WFIWRLDPHSAAYNIPVALRLKGPLRRDALQGALDLLVQRHETLRTTFVEHDGAPRQVIHPTLPIAIE-ERRPPVAGEDL 1200
Cdd:PRK12316  2613 WFLWQLEPESAAYHLPSALHLRGVLDQAALEQAFDALVLRHETLRTRFVEVGEQTRQVILPNMSLRIVlEDCAGVADAAI 2692

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1201 KGLVETEAHRPFDLQRGPLLRVLLLPLATDECVLVLTLHHIIADGWSMQVLVDELIRVYAALRHDQPPALAELPIQYADF 1280
Cdd:PRK12316  2693 RQRVAEEIQRPFDLARGPLLRVRLLALDGQEHVLVITQHHIVSDGWSMQVMVDELVQAYAGARRGEQPTLPPLPLQYADY 2772

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1281 AAWQRQWMDGGERERQLDYWVSRLGGEQPLLELPSDRPRPQQQSHRGRRIGIPLPAELAEALRRLAQAEQGTLFMLLLAS 1360
Cdd:PRK12316  2773 AAWQRAWMDSGEGARQLDYWRERLGGEQPVLELPLDRPRPALQSHRGARLDVALDVALSRELLALARREGVTLFMLLLAS 2852

                         1370      1380      1390      1400      1410      1420      1430      1440
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1361 FQALLHRYSGQNDIRVGVPIANRNREETEGLIGFFVNTQVLRAELDGQLPFRELLRQVRQAVVEAQGHQDLPFEQLVDAL 1440
Cdd:PRK12316  2853 FQVLLHRYSGQSDIRVGVPIANRNRAETERLIGFFVNTQVLRAQVDAQLAFRDLLGQVKEQALGAQAHQDLPFEQLVEAL 2932

                         1450      1460      1470      1480      1490      1500      1510      1520
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1441 QPERSLSHAPLFQVMYNHQrDDHRGSrfASLGELEVEDLAWDVQTAQFDLTLDTYESSNGLLAELTYATDLFDASSAERI 1520
Cdd:PRK12316  2933 QPERSLSHSPLFQVMYNHQ-SGERAA--AQLPGLHIESFAWDGAATQFDLALDTWESAEGLGASLTYATDLFDARTVERL 3009

                         1530      1540      1550      1560      1570      1580      1590      1600
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1521 AGHWLNLLRSIVARPEARIAELKLLDEAEARADLLQWNPGPQDFTPASCLHRLIERQAAERPRATAVVYGERALDYGELN 1600
Cdd:PRK12316  3010 ARHWQNLLRGMVENPQRSVDELAMLDAEERGQLLEAWNATAAEYPLERGVHRLFEEQVERTPDAVALAFGEQRLSYAELN 3089

                         1610      1620      1630      1640      1650      1660      1670      1680
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1601 LRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGYMIEDSGIRLLLTQraARERLP 1680
Cdd:PRK12316  3090 RRANRLAHRLIERGVGPDVLVGVAVERSLEMVVGLLAILKAGGAYVPLDPEYPEERLAYMLEDSGAQLLLSQ--SHLRLP 3167

                         1690      1700      1710      1720      1730      1740      1750      1760
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1681 LGEGLPCLLLDAEHEwaGYPESDPQSAVGVDNLAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRHWFGFSADDAWSLFHS 1760
Cdd:PRK12316  3168 LAQGVQVLDLDRGDE--NYAEANPAIRTMPENLAYVIYTSGSTGKPKGVGIRHSALSNHLCWMQQAYGLGVGDRVLQFTT 3245

                         1770      1780      1790      1800      1810      1820      1830      1840
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1761 YAFDFSVWEIFGALLHGGRLVIVPYETSRSPEDFLRLLCRERVTVLNQTPSAFKQLMQVACAGQEVpplALRHVVFGGEA 1840
Cdd:PRK12316  3246 FSFDVFVEELFWPLMSGARVVLAGPEDWRDPALLVELINSEGVDVLHAYPSMLQAFLEEEDAHRCT---SLKRIVCGGEA 3322

                         1850      1860      1870      1880      1890      1900      1910      1920
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1841 LEVQALRPWFERFGdraprLVNMYGITETTVHVTYRPLSLadlDGGAASPIGEPIPDLSWYLLDAGLNPVPRGCIGELYV 1920
Cdd:PRK12316  3323 LPADLQQQVFAGLP-----LYNLYGPTEATITVTHWQCVE---EGKDAVPIGRPIANRACYILDGSLEPVPVGALGELYL 3394

                         1930      1940      1950      1960      1970      1980      1990      2000
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1921 GGAGLARGYLNRPELSCTRFVADPFSTtGGRLYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVA 2000
Cdd:PRK12316  3395 GGEGLARGYHNRPGLTAERFVPDPFVP-GERLYRTGDLARYRADGVIEYIGRVDHQVKIRGFRIELGEIEARLLEHPWVR 3473

                         2010      2020      2030      2040      2050      2060      2070      2080
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2001 EAVVLPHEGpgaTQLVGYVVTQAAPSDpaaLRDTLRQALKASLPEHMVPAHLLFLERLPLTANGKLDRRALPAPDASRLQ 2080
Cdd:PRK12316  3474 EAVVLAVDG---RQLVAYVVPEDEAGD---LREALKAHLKASLPEYMVPAHLLFLERMPLTPNGKLDRKALPRPDAALLQ 3547

                         2090      2100      2110      2120      2130      2140      2150      2160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2081 RDYTAPRSELEQRLAAIWADVLKLGRVGLDDNFFELGGDSIISIQVVSRARQAGIRLAPRDLFLHQTIRGLAGVAVEGRG 2160
Cdd:PRK12316  3548 QDYVAPVNELERRLAAIWADVLKLEQVGLTDNFFELGGDSIISLQVVSRARQAGIRFTPKDLFQHQTIQGLARVARVGGG 3627

                         2170      2180      2190      2200      2210      2220      2230      2240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2161 LAcAEQGPISGSTPLLPIQQMFFELDIPRRQHWNQSVLLEPGQALDGTLLETALQALLAHHDALRLGFRLEDGTWRAEHR 2240
Cdd:PRK12316  3628 VA-VDQGPVSGETLLLPIQQQFFEEPVPERHHWNQSLLLKPREALDAAALEAALQALVEHHDALRLRFVEDAGGWTAEHL 3706

                         2250      2260      2270      2280      2290      2300      2310      2320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2241 AVEAGEVLLWQQSVADGQALEALAEQVQRSLDLGSGPLLRALLATLGDGSQRLLLVIHHLVVDGVSWRILLEDLQTAYRQ 2320
Cdd:PRK12316  3707 PVELGGALLWRAELDDAEELERLGEEAQRSLDLADGPLLRALLATLADGSQRLLLVIHHLVVDGVSWRILLEDLQQAYQQ 3786

                         2330      2340      2350      2360      2370      2380      2390      2400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2321 LQAGQAVALPAKTSAFKAWAERLQAHARDGGLEGERGYWLAQLEGVSTELPCDDREGAQSVRHVRSARTELTEEATRRLL 2400
Cdd:PRK12316  3787 LLQGEAPRLPAKTSSFKAWAERLQEHARGEALKAELAYWQEQLQGVSSELPCDHPQGALQNRHAASVQTRLDRELTRRLL 3866

                         2410      2420      2430      2440      2450      2460      2470      2480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2401 QEAPAAYRTQVNDLLLTALARVIGRWTGQADTLIQLEGHGREELFEDIDLTRTVGWFTSLFPLRLSPVAELGASIKRIKE 2480
Cdd:PRK12316  3867 QQAPAAYRTQVNDLLLTALARVVCRWTGEASALVQLEGHGREDLFADIDLSRTVGWFTSLFPVRLSPVEDLGASIKAIKE 3946

                         2490      2500      2510      2520      2530      2540      2550      2560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2481 QLRAIPHKGLGFGALRYLGSAEDRAALAALPSPRITFNYLGQFDGSFSADsSALFRPSADAAGSERDSDAPLDNWLSLNG 2560
Cdd:PRK12316  3947 QLRAIPNKGIGFGLLRYLGDEESRRTLAGLPVPRITFNYLGQFDGSFDEE-MALFVPAGESAGAEQSPDAPLDNWLSLNG 4025

                         2570      2580      2590      2600      2610      2620      2630      2640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2561 QVYAGRLGIDWSFSAARFSEASILRLADAYRDELLALIEHCCAADVEGVTPSDFPLAGLDQRQLDALPLAAGEVEDLYPL 2640
Cdd:PRK12316  4026 RVYGGELSLDWTFSREMFEEATIQRLADDYAAELTALVEHCCDAERHGVTPSDFPLAGLDQARLDALPLPLGEIEDIYPL 4105

                         2650      2660      2670      2680      2690      2700      2710      2720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2641 SPMQQGMLFHSLYQQNSGDYINQMRLDVEGLDPQRFREAWQAALDAHEVLRSGFLWQGALEKPLQLVRKRVEVPFSVHDW 2720
Cdd:PRK12316  4106 SPMQQGMLFHSLYEQEAGDYINQMRVDVQGLDVERFRAAWQAALDRHDVLRSGFVWQGELGRPLQVVHKQVSLPFAELDW 4185

                         2730      2740      2750      2760      2770      2780      2790      2800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2721 RDRADLAEALDALAAGEAGLGFELAEAPLLRLVLVRTGERRHHLIYTNHHILMDGWSNSQLLGEVLQRYRGETPSRSDGR 2800
Cdd:PRK12316  4186 RGRADLQAALDALAAAERERGFDLQRAPLLRLVLVRTAEGRHHLIYTNHHILMDGWSNSQLLGEVLERYSGRPPAQPGGR 4265

                         2810      2820      2830      2840      2850      2860      2870      2880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2801 YRDYIAWLQRQDAGRTEAFWKQRLQRLGEPTLLVPAFAH-GVRGAEGHADRYRQLDVTTSQRLAEFAREQKVTLNTLVQA 2879
Cdd:PRK12316  4266 YRDYIAWLQRQDAAASEAFWREQLAALDEPTRLAQAIARaDLRSANGYGEHVRELDATATARLREFARTQRVTLNTLVQA 4345

                         2890      2900      2910      2920      2930      2940      2950      2960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2880 AWLILLQRFTGQDTVAFGATVSGRPAELRGIEEQIGLFINTLPVVASPCPEQPIGDWLQAVQGENLALREFEHTPLYDIQ 2959
Cdd:PRK12316  4346 AWLLLLQRYTGQDTVAFGATVAGRPAELPGIEGQIGLFINTLPVIATPRAQQSVVEWLQQVQRQNLALREHEHTPLYEIQ 4425

                         2970      2980      2990      3000      3010      3020      3030      3040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2960 RWAGQVGEALFDNILVFENYPVSAALAEETPADMRIDALSNQEQTHYPLTLLVSAGETLELHYSYSRQAFDEAAIECLAE 3039
Cdd:PRK12316  4426 RWAGQGGEALFDSLLVFENYPVSEALQQGAPGGLRFGEVTNHEQTNYPLTLAVGLGETLSLQFSYDRGHFDAATIERLAR 4505

                         3050      3060      3070      3080      3090      3100      3110      3120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3040 RLERLLLGMCENPGASLGELDSLAVAERYQLLEGWNATAAEYPLQRGVHRLFEEQVERTPTAPALAFGEERLDYAELNRR 3119
Cdd:PRK12316  4506 HLTNLLEAMAEDPQRRLGELQLLEKAEQQRIVALWNRTDAGYPATRCVHQLVAERARMTPDAVAVVFDEEKLTYAELNRR 4585

                         3130      3140      3150      3160      3170      3180
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2183974163 3120 ANRLAHALIERGIGADRLVGVAMERSIEMVVALMAILKAGGAYVPVDPEYPEERQAYMLEDSGV 3183
Cdd:PRK12316  4586 ANRLAHALIARGVGPEVLVGIAMERSAEMMVGLLAVLKAGGAYVPLDPEYPRERLAYMMEDSGA 4649

PRK05691

peptide synthase; Validated

14-3183

0e+00

peptide synthase; Validated

Pssm-ID: 235564 [Multi-domain] Cd Length: 4334 Bit Score: 3130.99 E-value: 0e+00

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163   14 LPLDKRMLY-----------LAKMQEEGvTPANLPIPEVASAfERIPLSYAQERQWFLWQMDPQSAAYNIPSALRLRGEL 82
Cdd:PRK05691   633 IDLNLRQLFeaptlaafsaaVARQLAGG-GAAQAAIARLPRG-QALPQSLAQNRLWLLWQLDPQSAAYNIPGGLHLRGEL 710

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163   83 DVEALSASLGAIVERHQSLRTVFVEDeqlDGFR-QQVLASVDVPV-PVTLAG--DDDAQAQIRAFVESETQQPFDLRNGP 158
Cdd:PRK05691   711 DEAALRASFQRLVERHESLRTRFYER---DGVAlQRIDAQGEFALqRIDLSDlpEAEREARAAQIREEEARQPFDLEKGP 787

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  159 LLRARLLRLAADDHVLTLTIHHVAADGWSMRVLVEELIALYGARRQGIEATLPDLPIQYADYAIWQRHWLEAGERERQLE 238
Cdd:PRK05691   788 LLRVTLVRLDDEEHQLLVTLHHIVADGWSLNILLDEFSRLYAAACQGQTAELAPLPLGYADYGAWQRQWLAQGEAARQLA 867

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  239 YWMARLGGGQSVLELPTDRQRPALPSYRGARHELQLPQALGRQLQALAQREGTTLFMLLLASFQALLHRYSGQDEIRVGV 318
Cdd:PRK05691   868 YWKAQLGDEQPVLELATDHPRSARQAHSAARYSLRVDASLSEALRGLAQAHQATLFMVLLAAFQALLHRYSGQGDIRIGV 947

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  319 PVANRNRVETERLIGFFVNTQVLRADLDAQMPFLDLLQQTRVAALGAQSHQDLPFEQLVEALQPERSlshSPLFQAMYNH 398
Cdd:PRK05691   948 PNANRPRLETQGLVGFFINTQVLRAQLDGRLPFTALLAQVRQATLGAQAHQDLPFEQLVEALPQARE---QGLFQVMFNH 1024

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  399 Q--NLGSAGRqslaaqLPGLSVEDLSWGAHSAQFDLTLDTYESEQG-VHAEFTYATDLFEAATVERLARHWRNLLEAVVA 475
Cdd:PRK05691  1025 QqrDLSALRR------LPGLLAEELPWHSREAKFDLQLHSEEDRNGrLTLSFDYAAELFDAATIERLAEHFLALLEQVCE 1098

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  476 EPRRRLGDLPLLDAEERATLLQRSRLPASeyPAGQGVHRLFEAQAGLTPDAPALLFGEERLSYAELNALANRLAWRLREE 555
Cdd:PRK05691  1099 DPQRALGDVQLLDAAERAQLAQWGQAPCA--PAQAWLPELLNEQARQTPERIALVWDGGSLDYAELHAQANRLAHYLRDK 1176

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  556 GVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQYMIDDSGLRLLLSQQSVLARLPQSDGLQSLLLDDL 635
Cdd:PRK05691  1177 GVGPDVCVAIAAERSPQLLVGLLAILKAGGAYVPLDPDYPAERLAYMLADSGVELLLTQSHLLERLPQAEGVSAIALDSL 1256

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  636 ErlVHGYPAENPDLPEAPDSLCYAIYTSGSTGQPKGVMVRHRALTNFVCSIARQPGMLARDRLLSVTTFSFDIFGLELYV 715
Cdd:PRK05691  1257 H--LDSWPSQAPGLHLHGDNLAYVIYTSGSTGQPKGVGNTHAALAERLQWMQATYALDDSDVLMQKAPISFDVSVWECFW 1334

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  716 PLARGASMLLASREQAQDPEALLDLVERQGVTVLQATPATWRMLCDSErvdLLRGCT----LLCGGEALAEDLAARMRGL 791
Cdd:PRK05691  1335 PLITGCRLVLAGPGEHRDPQRIAELVQQYGVTTLHFVPPLLQLFIDEP---LAAACTslrrLFSGGEALPAELRNRVLQR 1411

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  792 --SASTWNLYGPTETTI----WSARFRLGEeaRPFLGGPLENTALYILDSEMNPCPPGVAGELLIGGDGLARGYHRRPGL 865
Cdd:PRK05691  1412 lpQVQLHNRYGPTETAInvthWQCQAEDGE--RSPIGRPLGNVLCRVLDAELNLLPPGVAGELCIGGAGLARGYLGRPAL 1489

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  866 TAERFLPDPFAADGSRLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQPGVAGPTL 945
Cdd:PRK05691  1490 TAERFVPDPLGEDGARLYRTGDRARWNADGALEYLGRLDQQVKLRGFRVEPEEIQARLLAQPGVAQAAVLVREGAAGAQL 1569

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  946 VAYLvpTEAALVDAESARqqelrsaLKNSLLAVLPDYMVPAHMLLLENLPLTPNGKINRKALPLPDASavRDAHVAPEGE 1025
Cdd:PRK05691  1570 VGYY--TGEAGQEAEAER-------LKAALAAELPEYMVPAQLIRLDQMPLGPSGKLDRRALPEPVWQ--QREHVEPRTE 1638

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1026 LERAMAAIWSEVLKLGHIGRDDNFFELGGHSLLVTQVVSRVRRRLDLQVPLRTLFEHSTLRAYAQAVAQLAPAA----QG 1101
Cdd:PRK05691  1639 LQQQIAAIWREVLGLPRVGLRDDFFALGGHSLLATQIVSRTRQACDVELPLRALFEASELGAFAEQVARIQAAGernsQG 1718

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1102 GIVRCARDASPQLSFAQERQWFIWRLDPHSAAYNIPVALRLKGPLRRDALQGALDLLVQRHETLRTTFVEHDGAPRQVIH 1181
Cdd:PRK05691  1719 AIARVDRSQPVPLSYSQQRMWFLWQMEPDSPAYNVGGMARLSGVLDVDRFEAALQALILRHETLRTTFPSVDGVPVQQVA 1798

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1182 ------------PTLPIAIEERRppvagedLKGLVETEAHRPFDLQRGPLLRVLLLPLATDECVLVLTLHHIIADGWSMQ 1249
Cdd:PRK05691  1799 edsglrmdwqdfSALPADARQQR-------LQQLADSEAHQPFDLERGPLLRACLVKAAEREHYFVLTLHHIVTEGWAMD 1871

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1250 VLVDELIRVYAALRHDQPPALAELPIQYADFAAWQRQWMDGGERERQLDYWVSRLGGEQPLLELPSDRPRPQQQSHRGRR 1329
Cdd:PRK05691  1872 IFARELGALYEAFLDDRESPLEPLPVQYLDYSVWQRQWLESGERQRQLDYWKAQLGNEHPLLELPADRPRPPVQSHRGEL 1951

                         1370      1380      1390      1400      1410      1420      1430      1440
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1330 IGIPLPAELAEALRRLAQAEQGTLFMLLLASFQALLHRYSGQNDIRVGVPIANRNREETEGLIGFFVNTQVLRAELDGQL 1409
Cdd:PRK05691  1952 YRFDLSPELAARVRAFNAQRGLTLFMTMTATLAALLYRYSGQRDLRIGAPVANRIRPESEGLIGAFLNTQVLRCQLDGQM 2031

                         1450      1460      1470      1480      1490      1500      1510      1520
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1410 PFRELLRQVRQAVVEAQGHQDLPFEQLVDALQPERSLSHAPLFQVMYNHQRDDHRGSRfaSLGELEVEDLAWDVQTAQFD 1489
Cdd:PRK05691  2032 SVSELLEQVRQTVIEGQSHQDLPFDHLVEALQPPRSAAYNPLFQVMCNVQRWEFQQSR--QLAGMTVEYLVNDARATKFD 2109

                         1530      1540      1550      1560      1570      1580      1590      1600
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1490 LTLDTYESSNGLLAELTYATDLFDASSAERIAGHWLNLLRSIVARPEARIAELKLLDEAEARADLLQWNPGPQDFTPASC 1569
Cdd:PRK05691  2110 LNLEVTDLDGRLGCCLTYSRDLFDEPRIARMAEHWQNLLEALLGDPQQRLAELPLLAAAEQQQLLDSLAGEAGEARLDQT 2189

                         1610      1620      1630      1640      1650      1660      1670      1680
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1570 LHRLIERQAAERPRATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLD 1649
Cdd:PRK05691  2190 LHGLFAAQAARTPQAPALTFAGQTLSYAELDARANRLARALRERGVGPQVRVGLALERSLEMVVGLLAILKAGGAYVPLD 2269

                         1690      1700      1710      1720      1730      1740      1750      1760
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1650 PRYPSDRLGYMIEDSGIRLLLTQRA---ARERLPLGEGLPCLLLDAEhEWAGYPESDPQSAVGVDNLAYVIYTSGSTGKP 1726
Cdd:PRK05691  2270 PEYPLERLHYMIEDSGIGLLLSDRAlfeALGELPAGVARWCLEDDAA-ALAAYSDAPLPFLSLPQHQAYLIYTSGSTGKP 2348

                         1770      1780      1790      1800      1810      1820      1830      1840
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1727 KGTLLPHGNVLRLFDATRHWFGFSADDAWSLFHSYAFDFSVWEIFGALLHGGRLVIVPyETSRSPEDFLRLLCRERVTVL 1806
Cdd:PRK05691  2349 KGVVVSHGEIAMHCQAVIERFGMRADDCELHFYSINFDAASERLLVPLLCGARVVLRA-QGQWGAEEICQLIREQQVSIL 2427

                         1850      1860      1870      1880      1890      1900      1910      1920
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1807 NQTPSAFKQLMQ-VACAGQEVPplaLRHVVFGGEAL---EVQALRPWFerfgdrAPRLV-NMYGITETTVhvtyRPL-SL 1880
Cdd:PRK05691  2428 GFTPSYGSQLAQwLAGQGEQLP---VRMCITGGEALtgeHLQRIRQAF------APQLFfNAYGPTETVV----MPLaCL 2494

                         1930      1940      1950      1960      1970      1980      1990      2000
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1881 A--DLDGGAAS-PIGEPIPDLSWYLLDAGLNPVPRGCIGELYVGGAGLARGYLNRPELSCTRFVADPFSTTGGRLYRTGD 1957
Cdd:PRK05691  2495 ApeQLEEGAASvPIGRVVGARVAYILDADLALVPQGATGELYVGGAGLAQGYHDRPGLTAERFVADPFAADGGRLYRTGD 2574

                         2010      2020      2030      2040      2050      2060      2070      2080
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1958 LARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVVLPHEGPGATQLVGYVVTQAAPSDP---AALRDT 2034
Cdd:PRK05691  2575 LVRLRADGLVEYVGRIDHQVKIRGFRIELGEIESRLLEHPAVREAVVLALDTPSGKQLAGYLVSAVAGQDDeaqAALREA 2654

                         2090      2100      2110      2120      2130      2140      2150      2160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2035 LRQALKASLPEHMVPAHLLFLERLPLTANGKLDRRALPAPDASRLQRDYTAPRSELEQRLAAIWADVLKLGRVGLDDNFF 2114
Cdd:PRK05691  2655 LKAHLKQQLPDYMVPAHLILLDSLPLTANGKLDRRALPAPDPELNRQAYQAPRSELEQQLAQIWREVLNVERVGLGDNFF 2734

                         2170      2180      2190      2200      2210      2220      2230      2240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2115 ELGGDSIISIQVVSRARQAGIRLAPRDLFLHQTIRGLAGVAVEgRGLACAEQGPISGSTPLLPIQQMFFELDIPRRQHWN 2194
Cdd:PRK05691  2735 ELGGDSILSIQVVSRARQLGIHFSPRDLFQHQTVQTLAAVATH-SEAAQAEQGPLQGASGLTPIQHWFFDSPVPQPQHWN 2813

                         2250      2260      2270      2280      2290      2300      2310      2320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2195 QSVLLEPGQALDGTLLETALQALLAHHDALRLGFRLEDGTWRAEHRAVEAGEvLLWQQSVADGQALEALAEQVQRSLDLG 2274
Cdd:PRK05691  2814 QALLLEPRQALDPALLEQALQALVEHHDALRLRFSQADGRWQAEYRAVTAQE-LLWQVTVADFAECAALFADAQRSLDLQ 2892

                         2330      2340      2350      2360      2370      2380      2390      2400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2275 SGPLLRALLATLGDGSQRLLLVIHHLVVDGVSWRILLEDLQTAYRQLQAGQAVALPAKTSAFKAWAERLQAHARDGGLEG 2354
Cdd:PRK05691  2893 QGPLLRALLVDGPQGQQRLLLAIHHLVVDGVSWRVLLEDLQALYRQLSAGAEPALPAKTSAFRDWAARLQAYAGSESLRE 2972

                         2410      2420      2430      2440      2450      2460      2470      2480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2355 ERGYWLAQLEGVSTELPCDDREGAQSVRHVRSARTELTEEATRRLLQEAPAAYRTQVNDLLLTALARVIGRWTGQADTLI 2434
Cdd:PRK05691  2973 ELGWWQAQLGGPRAELPCDRPQGGNLNRHAQTVSVRLDAERTRQLLQQAPAAYRTQVNDLLLTALARVLCRWSGQPSVLV 3052

                         2490      2500      2510      2520      2530      2540      2550      2560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2435 QLEGHGREELFEDIDLTRTVGWFTSLFPLRLSP----VAELGASIKRIKEQLRAIPHKGLGFGALRYLGSAEDRAALAAL 2510
Cdd:PRK05691  3053 QLEGHGREALFDDIDLTRSVGWFTSAYPLRLTPapgdDAARGESIKAIKEQLRAVPHKGLGYGVLRYLADAAVREAMAAL 3132

                         2570      2580      2590      2600      2610      2620      2630      2640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2511 PSPRITFNYLGQFDGSFSADssALFRPSADAAGSERDSDAPLDNWLSLNGQVYAGRLGIDWSFSAARFSEASILRLADAY 2590
Cdd:PRK05691  3133 PQAPITFNYLGQFDQSFASD--ALFRPLDEPAGPAHDPDAPLPNELSVDGQVYGGELVLRWTYSAERYDEQTIAELAEAY 3210

                         2650      2660      2670      2680      2690      2700      2710      2720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2591 RDELLALIEHCCAADVEGVTPSDFPLAGLDQRQLDALPLAAGEVEDLYPLSPMQQGMLFHSLYQQNSGDYINQMRLDVEG 2670
Cdd:PRK05691  3211 LAELQALIAHCLADGAGGLTPSDFPLAQLTQAQLDALPVPAAEIEDVYPLTPMQEGLLLHTLLEPGTGLYYMQDRYRINS 3290

                         2730      2740      2750      2760      2770      2780      2790      2800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2671 -LDPQRFREAWQAALDAHEVLRSGFLWQgALEKPLQLVRKRVEVPFSVHDWR--DRADLAEALDALAAGEAGLGFELAEA 2747
Cdd:PRK05691  3291 aLDPERFAQAWQAVVARHEALRASFSWN-AGETMLQVIHKPGRTPIDYLDWRglPEDGQEQRLQALHKQEREAGFDLLNQ 3369

                         2810      2820      2830      2840      2850      2860      2870      2880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2748 PLLRLVLVRTGERRHHLIYTNHHILMDGWSNSQLLGEVLQRYRGETPSR-----SDGRYRDYIAWLQRQDAGRTEAFWKQ 2822
Cdd:PRK05691  3370 PPFHLRLIRVDEARYWFMMSNHHILIDAWCRSLLMNDFFEIYTALGEGReaqlpVPPRYRDYIGWLQRQDLAQARQWWQD 3449

                         2890      2900      2910      2920      2930      2940      2950      2960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2823 RLQRLGEPTlLVPA---FAHGVRGAEGH---ADRYRQLDVTTSQRLAEFAREQKVTLNTLVQAAWLILLQRFTGQDTVAF 2896
Cdd:PRK05691  3450 NLRGFERPT-PIPSdrpFLREHAGDSGGmvvGDCYTRLDAADGARLRELAQAHQLTVNTFAQAAWALVLRRYSGDRDVLF 3528

                         2970      2980      2990      3000      3010      3020      3030      3040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2897 GATVSGRPAELRGIEEQIGLFINTLPV-VASPCPEQP--IGDWLQAVQGENLALREFEHTPLYDIQRWAG-QVGEALFDN 2972
Cdd:PRK05691  3529 GVTVAGRPVSMPQMQRTVGLFINSIALrVQLPAAGQRcsVRQWLQGLLDSNMELREYEYLPLVAIQECSElPKGQPLFDS 3608

                         3050      3060      3070      3080      3090      3100      3110      3120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2973 ILVFENYPVSAALAEETpadMRIDALSNQEQTH--YPLTLLVSAGETLELHYSYSRQAFDEAAIECLAERLERLLLGMCE 3050
Cdd:PRK05691  3609 LFVFENAPVEVSVLDRA---QSLNASSDSGRTHtnFPLTAVCYPGDDLGLHLSYDQRYFDAPTVERLLGEFKRLLLALVQ 3685

                         3130      3140      3150      3160      3170      3180      3190      3200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3051 NPGASLGELDSLAVAERYQLLEGWNATAAEYPLQRGVHRLFEEQVERTPTAPALAFGEERLDYAELNRRANRLAHALIER 3130
Cdd:PRK05691  3686 GFHGDLSELPLLGEQERDFLLDGCNRSERDYPLEQSYVRLFEAQVAAHPQRIAASCLDQQWSYAELNRAANRLGHALRAA 3765

                         3210      3220      3230      3240      3250
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2183974163 3131 GIGADRLVGVAMERSIEMVVALMAILKAGGAYVPVDPEYPEERQAYMLEDSGV 3183
Cdd:PRK05691  3766 GVGVDQPVALLAERGLDLLGMIVGSFKAGAGYLPLDPGLPAQRLQRIIELSRT 3818

PRK12316

peptide synthase; Provisional

1113-3183

0e+00

peptide synthase; Provisional

Pssm-ID: 237054 [Multi-domain] Cd Length: 5163 Bit Score: 2713.61 E-value: 0e+00

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1113 QLSFAQERQWFIWRLDPHSAAYNIPVALRLKGPLRRDALQGALDLLVQRHETLRTTFVEHDGAPRQVIHPTLPIAIEErr 1192
Cdd:PRK12316    51 RLSYAQQRMWFLWQLEPQSGAYNLPSAVRLNGPLDRQALERAFASLVQRHETLRTVFPRGADDSLAQVPLDRPLEVEF-- 128

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1193 ppvagEDLKGLVETE--------AHR----PFDLQRGPLLRVLLLPLATDECVLVLTLHHIIADGWSMQVLVDELIRVYA 1260
Cdd:PRK12316   129 -----EDCSGLPEAEqearlrdeAQReslqPFDLCEGPLLRVRLLRLGEEEHVLLLTLHHIVSDGWSMNVLIEEFSRFYS 203

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1261 ALRHDQPPALAELPIQYADFAAWQRQWMDGGERERQLDYWVSRLGGEQPLLELPSDRPRPQQQSHRGRRIGIPLPAELAE 1340
Cdd:PRK12316   204 AYATGAEPGLPALPIQYADYALWQRSWLEAGEQERQLEYWRAQLGEEHPVLELPTDHPRPAVPSYRGSRYEFSIDPALAE 283

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1341 ALRRLAQAEQGTLFMLLLASFQALLHRYSGQNDIRVGVPIANRNREETEGLIGFFVNTQVLRAELDGQLPFRELLRQVRQ 1420
Cdd:PRK12316   284 ALRGTARRQGLTLFMLLLGAFNVLLHRYSGQTDIRVGVPIANRNRAEVEGLIGFFVNTQVLRSVFDGRTRVATLLAGVKD 363

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1421 AVVEAQGHQDLPFEQLVDALQPERSLSHAPLFQVMYNHQRDDHRGSRFASLGELEVEDLAWDVQTAQFDLTLDTYESSNG 1500
Cdd:PRK12316   364 TVLGAQAHQDLPFERLVEALKVERSLSHSPLFQVMYNHQPLVADIEALDTVAGLEFGQLEWKSRTTQFDLTLDTYEKGGR 443

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1501 LLAELTYATDLFDASSAERIAGHWLNLLRSIVARPEARIAELKLLDEAEARADLLQWNPGPQDFTPASCLHRLIERQAAE 1580
Cdd:PRK12316   444 LHAALTYATDLFEARTVERMARHWQNLLRGMVENPQARVDELPMLDAEERGQLVEGWNATAAEYPLQRGVHRLFEEQVER 523

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1581 RPRATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGYM 1660
Cdd:PRK12316   524 TPEAPALAFGEETLDYAELNRRANRLAHALIERGVGPDVLVGVAMERSIEMVVALLAILKAGGAYVPLDPEYPAERLAYM 603

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1661 IEDSGIRLLLTQRAARERLPLGEGLPCLLLDAEHEW-AGYPESDPQSAVGVDNLAYVIYTSGSTGKPKGTLLPHGNVLRL 1739
Cdd:PRK12316   604 LEDSGVQLLLSQSHLGRKLPLAAGVQVLDLDRPAAWlEGYSEENPGTELNPENLAYVIYTSGSTGKPKGAGNRHRALSNR 683

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1740 FDATRHWFGFSADDAWSLFHSYAFDFSVWEIFGALLHGGRLVIVPYETSRSPEDFLRLLCRERVTVLNQTPSAFKQLMQV 1819
Cdd:PRK12316   684 LCWMQQAYGLGVGDTVLQKTPFSFDVSVWEFFWPLMSGARLVVAAPGDHRDPAKLVELINREGVDTLHFVPSMLQAFLQD 763

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1820 ACAGQEVPplaLRHVVFGGEALEVQALrpwfERFGDRAP--RLVNMYGITETTVHVTYrplSLADLDGGAASPIGEPIPD 1897
Cdd:PRK12316   764 EDVASCTS---LRRIVCSGEALPADAQ----EQVFAKLPqaGLYNLYGPTEAAIDVTH---WTCVEEGGDSVPIGRPIAN 833

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1898 LSWYLLDAGLNPVPRGCIGELYVGGAGLARGYLNRPELSCTRFVADPFSTtGGRLYRTGDLARYRCDGVVEYVGRIDHQV 1977
Cdd:PRK12316   834 LACYILDANLEPVPVGVLGELYLAGRGLARGYHGRPGLTAERFVPSPFVA-GERMYRTGDLARYRADGVIEYAGRIDHQV 912

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1978 KIRGFRIELGEIEARLLAQPGVAEAVVLPHEGpgaTQLVGYVVTQAAPSDpaaLRDTLRQALKASLPEHMVPAHLLFLER 2057
Cdd:PRK12316   913 KLRGLRIELGEIEARLLEHPWVREAAVLAVDG---KQLVGYVVLESEGGD---WREALKAHLAASLPEYMVPAQWLALER 986

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2058 LPLTANGKLDRRALPAPDASRLQRDYTAPRSELEQRLAAIWADVLKLGRVGLDDNFFELGGDSIISIQVVSRARQAGIRL 2137
Cdd:PRK12316   987 LPLTPNGKLDRKALPAPEASVAQQGYVAPRNALERTLAAIWQDVLGVERVGLDDNFFELGGDSIVSIQVVSRARQAGIQL 1066

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2138 APRDLFLHQTIRGLAGVAVEGRGLAcAEQGPISGSTPLLPIQQMFFELDIPRRQHWNQSVLLEPGQALDGTLLETALQAL 2217
Cdd:PRK12316  1067 SPRDLFQHQTIRSLALVAKAGQATA-ADQGPASGEVALAPVQRWFFEQAIPQRQHWNQSLLLQARQPLDPDRLGRALERL 1145

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2218 LAHHDALRLGFRLEDGTWRAEHRAVEAGEVLlWQQSVADGQALEALAEQVQRSLDLGSGPLLRALLATLGDGSQRLLLVI 2297
Cdd:PRK12316  1146 VAHHDALRLRFREEDGGWQQAYAAPQAGEVL-WQRQAASEEELLALCEEAQRSLDLEQGPLLRALLVDMADGSQRLLLVI 1224

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2298 HHLVVDGVSWRILLEDLQTAYRQLQAgqavALPAKTSAFKAWAERLQAHArdGGLEGERGYWLAQLEGVSTELPCDDREG 2377
Cdd:PRK12316  1225 HHLVVDGVSWRILLEDLQRAYADLDA----DLPARTSSYQAWARRLHEHA--GARAEELDYWQAQLEDAPHELPCENPDG 1298

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2378 AQSVRHVRSARTELTEEATRRLLQEAPAAYRTQVNDLLLTALARVIGRWTGQADTLIQLEGHGREELFEDIDLTRTVGWF 2457
Cdd:PRK12316  1299 ALENRHERKLELRLDAERTRQLLQEAPAAYRTQVNDLLLTALARVTCRWSGQASVLVQLEGHGREDLFEDIDLSRTVGWF 1378

                         1370      1380      1390      1400      1410      1420      1430      1440
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2458 TSLFPLRLSPVAELGASIKRIKEQLRAIPHKGLGFGALRYLGSAEDRAALAALPSPRITFNYLGQFDGSFsaDSSALFRP 2537
Cdd:PRK12316  1379 TSLFPVRLTPAADLGESIKAIKEQLRAVPDKGIGYGLLRYLAGEEAAARLAALPQPRITFNYLGQFDRQF--DEAALFVP 1456

                         1450      1460      1470      1480      1490      1500      1510      1520
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2538 SADAAGSERDSDAPLDNWLSLNGQVYAGRLGIDWSFSAARFSEASILRLADAYRDELLALIEHCCAADVEGVTPSDFPLA 2617
Cdd:PRK12316  1457 ATESAGAAQDPCAPLANWLSIEGQVYGGELSLHWSFSREMFAEATVQRLADDYARELQALIEHCCDERNRGVTPSDFPLA 1536

                         1530      1540      1550      1560      1570      1580      1590      1600
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2618 GLDQRQLDALPLAAGEVEDLYPLSPMQQGMLFHSLYQQNSGDYINQMRLDVEGLDPQRFREAWQAALDAHEVLRSGFLWQ 2697
Cdd:PRK12316  1537 GLSQAQLDALPLPAGEIADIYPLSPMQQGMLFHSLYEQEAGDYINQLRVDVQGLDPDRFRAAWQATVDRHEILRSGFLWQ 1616

                         1610      1620      1630      1640      1650      1660      1670      1680
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2698 GALEKPLQLVRKRVEVPFSVHDWRDRADLAEALDALAAGEAGLGFELAEAPLLRLVLVRTGERRHHLIYTNHHILMDGWS 2777
Cdd:PRK12316  1617 DGLEQPLQVIHKQVELPFAELDWRGREDLGQALDALAQAERQKGFDLTRAPLLRLVLVRTGEGRHHLIYTNHHILMDGWS 1696

                         1690      1700      1710      1720      1730      1740      1750      1760
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2778 NSQLLGEVLQRYRGETPSRSDGRYRDYIAWLQRQDAGRTEAFWKQRLQRLGEPTLLVPAFAhGVRGAEGHADRYRQLDVT 2857
Cdd:PRK12316  1697 NAQLLGEVLQRYAGQPVAAPGGRYRDYIAWLQRQDAAASEAFWKEQLAALEEPTRLAQAAR-TEDGQVGYGDHQQLLDPA 1775

                         1770      1780      1790      1800      1810      1820      1830      1840
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2858 TSQRLAEFAREQKVTLNTLVQAAWLILLQRFTGQDTVAFGATVSGRPAELRGIEEQIGLFINTLPVVASPCPEQPIGDWL 2937
Cdd:PRK12316  1776 QTRALAEFARAQKVTLNTLVQAAWLLLLQRYTGQETVAFGATVAGRPAELPGIEQQIGLFINTLPVIAAPRPDQSVADWL 1855

                         1850      1860      1870      1880      1890      1900      1910      1920
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2938 QAVQGENLALREFEHTPLYDIQRWAGQVGEALFDNILVFENYPVSAALAEETPADMRIDALSNQEQTHYPLTLLVSAGET 3017
Cdd:PRK12316  1856 QEVQALNLALREHEHTPLYDIQRWAGQGGEALFDSLLVFENYPVAEALKQGAPAGLVFGRVSNHEQTNYPLTLAVTLGET 1935

                         1930      1940      1950      1960      1970      1980      1990      2000
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3018 LELHYSYSRQAFDEAAIECLAERLERLLLGMCENPGASLGELDSLAVAERYQLLEGWNATAAEYPLQRGVHRLFEEQVER 3097
Cdd:PRK12316  1936 LSLQYSYDRGHFDAAAIERLDRHLLHLLEQMAEDAQAALGELALLDAGERQRILADWDRTPEAYPRGPGVHQRIAEQAAR 2015

                         2010      2020      2030      2040      2050      2060      2070      2080
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3098 TPTAPALAFGEERLDYAELNRRANRLAHALIERGIGADRLVGVAMERSIEMVVALMAILKAGGAYVPVDPEYPEERQAYM 3177
Cdd:PRK12316  2016 APEAIAVVFGDQHLSYAELDSRANRLAHRLRARGVGPEVRVAIAAERSFELVVALLAVLKAGGAYVPLDPNYPAERLAYM 2095


                   ....*.
gi 2183974163 3178 LEDSGV 3183
Cdd:PRK12316  2096 LEDSGA 2101

PRK12316

peptide synthase; Provisional

4-1371

0e+00

peptide synthase; Provisional

Pssm-ID: 237054 [Multi-domain] Cd Length: 5163 Bit Score: 1403.93 E-value: 0e+00

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163    4 ALRVARRFITLPLDKRMLYLAKMQEEGVTPANLPIPEVASAFERIPLSYAQERQWFLWQMDPQSAAYNIPSALRLRGELD 83
Cdd:PRK12316     6 SLKLARRFIELPLEKRRVFLATLRGEGVDFSLFPIPAGVSSAERDRLSYAQQRMWFLWQLEPQSGAYNLPSAVRLNGPLD 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163   84 VEALSASLGAIVERHQSLRTVFVEdeQLDGFRQQVLASVDVPVP-VTLAGDDDA--QAQIRAFVESETQQPFDLRNGPLL 160
Cdd:PRK12316    86 RQALERAFASLVQRHETLRTVFPR--GADDSLAQVPLDRPLEVEfEDCSGLPEAeqEARLRDEAQRESLQPFDLCEGPLL 163

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  161 RARLLRLAADDHVLTLTIHHVAADGWSMRVLVEELIALYGARRQGIEATLPDLPIQYADYAIWQRHWLEAGERERQLEYW 240
Cdd:PRK12316   164 RVRLLRLGEEEHVLLLTLHHIVSDGWSMNVLIEEFSRFYSAYATGAEPGLPALPIQYADYALWQRSWLEAGEQERQLEYW 243

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  241 MARLGGGQSVLELPTDRQRPALPSYRGARHELQLPQALGRQLQALAQREGTTLFMLLLASFQALLHRYSGQDEIRVGVPV 320
Cdd:PRK12316   244 RAQLGEEHPVLELPTDHPRPAVPSYRGSRYEFSIDPALAEALRGTARRQGLTLFMLLLGAFNVLLHRYSGQTDIRVGVPI 323

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  321 ANRNRVETERLIGFFVNTQVLRADLDAQMPFLDLLQQTRVAALGAQSHQDLPFEQLVEALQPERSLSHSPLFQAMYNHQN 400
Cdd:PRK12316   324 ANRNRAEVEGLIGFFVNTQVLRSVFDGRTRVATLLAGVKDTVLGAQAHQDLPFERLVEALKVERSLSHSPLFQVMYNHQP 403

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  401 LgsAGRQSLAAQLPGLSVEDLSWGAHSAQFDLTLDTYESEQGVHAEFTYATDLFEAATVERLARHWRNLLEAVVAEPRRR 480
Cdd:PRK12316   404 L--VADIEALDTVAGLEFGQLEWKSRTTQFDLTLDTYEKGGRLHAALTYATDLFEARTVERMARHWQNLLRGMVENPQAR 481

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  481 LGDLPLLDAEERATLLQRSRLPASEYPAGQGVHRLFEAQAGLTPDAPALLFGEERLSYAELNALANRLAWRLREEGVGSD 560
Cdd:PRK12316   482 VDELPMLDAEERGQLVEGWNATAAEYPLQRGVHRLFEEQVERTPEAPALAFGEETLDYAELNRRANRLAHALIERGVGPD 561

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  561 VLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQYMIDDSGLRLLLSQQSVLARLPQSDGLQSLLLDDLERLVH 640
Cdd:PRK12316   562 VLVGVAMERSIEMVVALLAILKAGGAYVPLDPEYPAERLAYMLEDSGVQLLLSQSHLGRKLPLAAGVQVLDLDRPAAWLE 641

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  641 GYPAENPDLPEAPDSLCYAIYTSGSTGQPKGVMVRHRALTNFVCSIARQPGMLARDRLLSVTTFSFDIFGLELYVPLARG 720
Cdd:PRK12316   642 GYSEENPGTELNPENLAYVIYTSGSTGKPKGAGNRHRALSNRLCWMQQAYGLGVGDTVLQKTPFSFDVSVWEFFWPLMSG 721

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  721 ASMLLASREQAQDPEALLDLVERQGVTVLQATPATWRMLCDSERVDLLRGCTLL-CGGEALAEDLAARMRGL--SASTWN 797
Cdd:PRK12316   722 ARLVVAAPGDHRDPAKLVELINREGVDTLHFVPSMLQAFLQDEDVASCTSLRRIvCSGEALPADAQEQVFAKlpQAGLYN 801

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  798 LYGPTETTI----WSARFRLGEEarPFLGGPLENTALYILDSEMNPCPPGVAGELLIGGDGLARGYHRRPGLTAERFLPD 873
Cdd:PRK12316   802 LYGPTEAAIdvthWTCVEEGGDS--VPIGRPIANLACYILDANLEPVPVGVLGELYLAGRGLARGYHGRPGLTAERFVPS 879

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  874 PFaADGSRLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQpgvAGPTLVAYLVPTE 953
Cdd:PRK12316   880 PF-VAGERMYRTGDLARYRADGVIEYAGRIDHQVKLRGLRIELGEIEARLLEHPWVREAAVLAV---DGKQLVGYVVLES 955

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  954 AALVdaesarqqeLRSALKNSLLAVLPDYMVPAHMLLLENLPLTPNGKINRKALPLPDASAVRDAHVAPEGELERAMAAI 1033
Cdd:PRK12316   956 EGGD---------WREALKAHLAASLPEYMVPAQWLALERLPLTPNGKLDRKALPAPEASVAQQGYVAPRNALERTLAAI 1026

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1034 WSEVLKLGHIGRDDNFFELGGHSLLVTQVVSRVRRRlDLQVPLRTLFEHSTLRAYAQAV--AQLAPAAQGgivrcarDAS 1111
Cdd:PRK12316  1027 WQDVLGVERVGLDDNFFELGGDSIVSIQVVSRARQA-GIQLSPRDLFQHQTIRSLALVAkaGQATAADQG-------PAS 1098

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1112 PQLSFAQERQWFIWRLDPHSAAYNIPVALRLKGPLRRDALQGALDLLVQRHETLRTTFVEHDGAPRQVIHPTLPIAIEER 1191
Cdd:PRK12316  1099 GEVALAPVQRWFFEQAIPQRQHWNQSLLLQARQPLDPDRLGRALERLVAHHDALRLRFREEDGGWQQAYAAPQAGEVLWQ 1178

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1192 RPPVAGEDLKGLVEtEAHRPFDLQRGPLLRVLLLPLATDECVLVLTLHHIIADGWSMQVLVDELIRVYAALrhdqppaLA 1271
Cdd:PRK12316  1179 RQAASEEELLALCE-EAQRSLDLEQGPLLRALLVDMADGSQRLLLVIHHLVVDGVSWRILLEDLQRAYADL-------DA 1250

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1272 ELPIQYADFAAW-QRQWMDGGERERQLDYWVSRLGGEQPllELPSDRPRPQQQSHRGRRIGIPLPAELAEALRRLAQAEQ 1350
Cdd:PRK12316  1251 DLPARTSSYQAWaRRLHEHAGARAEELDYWQAQLEDAPH--ELPCENPDGALENRHERKLELRLDAERTRQLLQEAPAAY 1328

                         1370      1380
                   ....*....|....*....|..
gi 2183974163 1351 GTLFM-LLLASFQALLHRYSGQ 1371
Cdd:PRK12316  1329 RTQVNdLLLTALARVTCRWSGQ 1350

PRK05691

peptide synthase; Validated

518-2434

0e+00

peptide synthase; Validated

Pssm-ID: 235564 [Multi-domain] Cd Length: 4334 Bit Score: 1196.52 E-value: 0e+00

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  518 AQAGLTPDAPALLF----GEER--LSYAELNALANRLAWRLREEGVGSDVLVgIALERGVPMVVALLAVLKAGGAYVPLD 591
Cdd:PRK05691    17 RRAAQTPDRLALRFladdPGEGvvLSYRDLDLRARTIAAALQARASFGDRAV-LLFPSGPDYVAAFFGCLYAGVIAVPAY 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  592 P-----QYPADRLQYMIDDSGLRLLLSQQSVLARLPQSDGL------QSLLLDDLERLvhgyPAENPDLPE-APDSLCYA 659
Cdd:PRK05691    96 PpesarRHHQERLLSIIADAEPRLLLTVADLRDSLLQMEELaaanapELLCVDTLDPA----LAEAWQEPAlQPDDIAFL 171

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  660 IYTSGSTGQPKGVMVRHRALTNFVCSIARQPGMLAR--DRLLSVTTFSFDIfGL--ELYVPLARGAS-MLLASREQAQDP 734
Cdd:PRK05691   172 QYTSGSTALPKGVQVSHGNLVANEQLIRHGFGIDLNpdDVIVSWLPLYHDM-GLigGLLQPIFSGVPcVLMSPAYFLERP 250

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  735 EALLDLVERQGVTVLQATPATWRmLCdSERV--------DLLRGCTLLCGGEALAEDLAARMR------GLSASTW-NLY 799
Cdd:PRK05691   251 LRWLEAISEYGGTISGGPDFAYR-LC-SERVsesalerlDLSRWRVAYSGSEPIRQDSLERFAekfaacGFDPDSFfASY 328

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  800 GPTETTIWSARFRLGE---------------EARPFLGGPLENT-------ALYILDSE-MNPCPPGVAGELLIGGDGLA 856
Cdd:PRK05691   329 GLAEATLFVSGGRRGQgipaleldaealarnRAEPGTGSVLMSCgrsqpghAVLIVDPQsLEVLGDNRVGEIWASGPSIA 408

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  857 RGYHRRPGLTAERFLpdpfAADGSRLYRTGDLArYRADGVIEYLGRIDHQVKIRGFRIELGEIEtRLLEqdsvREAVVVA 936
Cdd:PRK05691   409 HGYWRNPEASAKTFV----EHDGRTWLRTGDLG-FLRDGELFVTGRLKDMLIVRGHNLYPQDIE-KTVE----REVEVVR 478

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  937 QPGVAgptlvAYLVP---TEAALVDAESAR--QQELRS-ALKNSLLAVLPD--YMVPAHMLLLE--NLPLTPNGKINRKA 1006
Cdd:PRK05691   479 KGRVA-----AFAVNhqgEEGIGIAAEISRsvQKILPPqALIKSIRQAVAEacQEAPSVVLLLNpgALPKTSSGKLQRSA 553

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1007 --LPLPDAS------------AVRDAHVAPEGELERAMAAIWSEVLKLGHIGRDDNFFELGGHSLLVTQVVSRVRRRLDL 1072
Cdd:PRK05691   554 crLRLADGSldsyalfpalqaVEAAQTAASGDELQARIAAIWCEQLKVEQVAADDHFFLLGGNSIAATQVVARLRDELGI 633

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1073 QVPLRTLFEHSTLRAYAQAVAQL---APAAQGGIVRCARDASPQLSFAQERQWFIWRLDPHSAAYNIPVALRLKGPLRRD 1149
Cdd:PRK05691   634 DLNLRQLFEAPTLAAFSAAVARQlagGGAAQAAIARLPRGQALPQSLAQNRLWLLWQLDPQSAAYNIPGGLHLRGELDEA 713

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1150 ALQGALDLLVQRHETLRTTFVEHDGAPRQVIHPTLPIAIE----ERRPPVAGEDLKGLV-ETEAHRPFDLQRGPLLRVLL 1224
Cdd:PRK05691   714 ALRASFQRLVERHESLRTRFYERDGVALQRIDAQGEFALQridlSDLPEAEREARAAQIrEEEARQPFDLEKGPLLRVTL 793

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1225 LPLATDECVLVLTLHHIIADGWSMQVLVDELIRVYAALRHDQPPALAELPIQYADFAAWQRQWMDGGERERQLDYWVSRL 1304
Cdd:PRK05691   794 VRLDDEEHQLLVTLHHIVADGWSLNILLDEFSRLYAAACQGQTAELAPLPLGYADYGAWQRQWLAQGEAARQLAYWKAQL 873

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1305 GGEQPLLELPSDRPRPQQQSHRGRRIGIPLPAELAEALRRLAQAEQGTLFMLLLASFQALLHRYSGQNDIRVGVPIANRN 1384
Cdd:PRK05691   874 GDEQPVLELATDHPRSARQAHSAARYSLRVDASLSEALRGLAQAHQATLFMVLLAAFQALLHRYSGQGDIRIGVPNANRP 953

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1385 REETEGLIGFFVNTQVLRAELDGQLPFRELLRQVRQAVVEAQGHQDLPFEQLVDALQPERSLShapLFQVMYNHQRDDHR 1464
Cdd:PRK05691   954 RLETQGLVGFFINTQVLRAQLDGRLPFTALLAQVRQATLGAQAHQDLPFEQLVEALPQAREQG---LFQVMFNHQQRDLS 1030

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1465 GSRfaSLGELEVEDLAWDVQTAQFDLTLDTYESSNGLLA-ELTYATDLFDASSAERIAGHWLNLLRSIVARPEARIAELK 1543
Cdd:PRK05691  1031 ALR--RLPGLLAEELPWHSREAKFDLQLHSEEDRNGRLTlSFDYAAELFDAATIERLAEHFLALLEQVCEDPQRALGDVQ 1108

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1544 LLDEAEaRADLLQWNPGPQdfTPAS-CLHRLIERQAAERPRATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVG 1622
Cdd:PRK05691  1109 LLDAAE-RAQLAQWGQAPC--APAQaWLPELLNEQARQTPERIALVWDGGSLDYAELHAQANRLAHYLRDKGVGPDVCVA 1185

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1623 LAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGYMIEDSGIRLLLTQRAARERLPLGEGLPCLLLDAEHeWAGYPES 1702
Cdd:PRK05691  1186 IAAERSPQLLVGLLAILKAGGAYVPLDPDYPAERLAYMLADSGVELLLTQSHLLERLPQAEGVSAIALDSLH-LDSWPSQ 1264

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1703 DPQSAVGVDNLAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRHWFGFSADDAWSLFHSYAFDFSVWEIFGALLHGGRLVI 1782
Cdd:PRK05691  1265 APGLHLHGDNLAYVIYTSGSTGQPKGVGNTHAALAERLQWMQATYALDDSDVLMQKAPISFDVSVWECFWPLITGCRLVL 1344

                         1370      1380      1390      1400      1410      1420      1430      1440
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1783 VPYETSRSPEDFLRLLCRERVTVLNQTPSAFKQLMQVACAGQevpPLALRHVVFGGEALEVqALRpwfERFGDRAP--RL 1860
Cdd:PRK05691  1345 AGPGEHRDPQRIAELVQQYGVTTLHFVPPLLQLFIDEPLAAA---CTSLRRLFSGGEALPA-ELR---NRVLQRLPqvQL 1417

                         1450      1460      1470      1480      1490      1500      1510      1520
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1861 VNMYGITETTVHVTYRPLSLADldgGAASPIGEPIPDLSWYLLDAGLNPVPRGCIGELYVGGAGLARGYLNRPELSCTRF 1940
Cdd:PRK05691  1418 HNRYGPTETAINVTHWQCQAED---GERSPIGRPLGNVLCRVLDAELNLLPPGVAGELCIGGAGLARGYLGRPALTAERF 1494

                         1530      1540      1550      1560      1570      1580      1590      1600
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1941 VADPFSTTGGRLYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVVLPHEGPGATQLVGYVV 2020
Cdd:PRK05691  1495 VPDPLGEDGARLYRTGDRARWNADGALEYLGRLDQQVKLRGFRVEPEEIQARLLAQPGVAQAAVLVREGAAGAQLVGYYT 1574

                         1610      1620      1630      1640      1650      1660      1670      1680
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2021 TQAAPSDPAalrDTLRQALKASLPEHMVPAHLLFLERLPLTANGKLDRRALPAPDAsrLQRDYTAPRSELEQRLAAIWAD 2100
Cdd:PRK05691  1575 GEAGQEAEA---ERLKAALAAELPEYMVPAQLIRLDQMPLGPSGKLDRRALPEPVW--QQREHVEPRTELQQQIAAIWRE 1649

                         1690      1700      1710      1720      1730      1740      1750      1760
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2101 VLKLGRVGLDDNFFELGGDSIISIQVVSRARQA-GIRLAPRDLFLHQTIRGLAgvAVEGRGLACAE---QGPI-----SG 2171
Cdd:PRK05691  1650 VLGLPRVGLRDDFFALGGHSLLATQIVSRTRQAcDVELPLRALFEASELGAFA--EQVARIQAAGErnsQGAIarvdrSQ 1727

                         1770      1780      1790      1800      1810      1820      1830      1840
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2172 STPLLPIQQ-MFFELDI-PRRQHWNQSVLLEPGQALDGTLLETALQALLAHHDALRLGFRLEDGTWRAEHRAvEAGEVLL 2249
Cdd:PRK05691  1728 PVPLSYSQQrMWFLWQMePDSPAYNVGGMARLSGVLDVDRFEAALQALILRHETLRTTFPSVDGVPVQQVAE-DSGLRMD 1806

                         1850      1860      1870      1880      1890      1900      1910      1920
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2250 WQQSVADG-----QALEALA-EQVQRSLDLGSGPLLRALLATLGDGSQRLLLVIHHLVVDGVSWRILLEDLQTAYRQLQA 2323
Cdd:PRK05691  1807 WQDFSALPadarqQRLQQLAdSEAHQPFDLERGPLLRACLVKAAEREHYFVLTLHHIVTEGWAMDIFARELGALYEAFLD 1886

                         1930      1940      1950      1960      1970      1980      1990      2000
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2324 GQA---VALPAKTSAFKAWaerlQAHARDGGlEGER--GYWLAQL--EGVSTELPCD-DREGAQSVRHvRSARTELTEEA 2395
Cdd:PRK05691  1887 DREsplEPLPVQYLDYSVW----QRQWLESG-ERQRqlDYWKAQLgnEHPLLELPADrPRPPVQSHRG-ELYRFDLSPEL 1960

                         2010      2020      2030      2040
                   ....*....|....*....|....*....|....*....|
gi 2183974163 2396 TRRLlqEAPAAYRTQVNDLLLTA-LARVIGRWTGQADTLI 2434
Cdd:PRK05691  1961 AARV--RAFNAQRGLTLFMTMTAtLAALLYRYSGQRDLRI 1998

EntF

EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites ...

1107-2421

0e+00

EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism];

Pssm-ID: 440643 [Multi-domain] Cd Length: 1329 Bit Score: 1123.41 E-value: 0e+00

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1107 ARDASPQLSFAQERQWFIWRLDPHSAAYNIPVALRLKGPLRRDALQGALDLLVQRHETLRTTFVEHDGAPRQVIHPTLPI 1186
Cdd:COG1020     13 AAAAPLPLSAAQQRLWLLLLLLLGSAAYNLALALLLLGLLLVAALLLLAALLARRRRALRTRLRTRAGRPVQVIQPVVAA 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1187 AIEERRPPVAGEDLKG-----LVETEAHRPFDLQRGPLLRVLLLPLATDECVLVLTLHHIIADGWSMQVLVDELIRVYAA 1261
Cdd:COG1020     93 PLPVVVLLVDLEALAEaaaeaAAAAEALAPFDLLRGPLLRLLLLLLLLLLLLLLLALHHIISDGLSDGLLLAELLRLYLA 172

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1262 LRHDQPPALAELPIQYADFAAWQRQWMDGGERERQLDYWVSRLGGEQPLLELPSDRPRPQQQSHRGRRIGIPLPAELAEA 1341
Cdd:COG1020    173 AYAGAPLPLPPLPIQYADYALWQREWLQGEELARQLAYWRQQLAGLPPLLELPTDRPRPAVQSYRGARVSFRLPAELTAA 252

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1342 LRRLAQAEQGTLFMLLLASFQALLHRYSGQNDIRVGVPIANRNREETEGLIGFFVNTQVLRAELDGQLPFRELLRQVRQA 1421
Cdd:COG1020    253 LRALARRHGVTLFMVLLAAFALLLARYSGQDDVVVGTPVAGRPRPELEGLVGFFVNTLPLRVDLSGDPSFAELLARVRET 332

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1422 VVEAQGHQDLPFEQLVDALQPERSLSHAPLFQVMYNHQRDDHRGSRfasLGELEVEDLAWDVQTAQFDLTLDTYESSNGL 1501
Cdd:COG1020    333 LLAAYAHQDLPFERLVEELQPERDLSRNPLFQVMFVLQNAPADELE---LPGLTLEPLELDSGTAKFDLTLTVVETGDGL 409

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1502 LAELTYATDLFDASSAERIAGHWLNLLRSIVARPEARIAELKLLDEAEARADLLQWNPGPQDFTPASCLHRLIERQAAER 1581
Cdd:COG1020    410 RLTLEYNTDLFDAATIERMAGHLVTLLEALAADPDQPLGDLPLLTAAERQQLLAEWNATAAPYPADATLHELFEAQAART 489

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1582 PRATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGYMI 1661
Cdd:COG1020    490 PDAVAVVFGDQSLTYAELNARANRLAHHLRALGVGPGDLVGVCLERSLEMVVALLAVLKAGAAYVPLDPAYPAERLAYML 569

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1662 EDSGIRLLLTQRAARERLPlGEGLPCLLLDAEhEWAGYPESDPQSAVGVDNLAYVIYTSGSTGKPKGTLLPHGNVLRLFD 1741
Cdd:COG1020    570 EDAGARLVLTQSALAARLP-ELGVPVLALDAL-ALAAEPATNPPVPVTPDDLAYVIYTSGSTGRPKGVMVEHRALVNLLA 647

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1742 ATRHWFGFSADDAWSLFHSYAFDFSVWEIFGALLHGGRLVIVPYETSRSPEDFLRLLCRERVTVLNQTPSAFKQLMQVAC 1821
Cdd:COG1020    648 WMQRRYGLGPGDRVLQFASLSFDASVWEIFGALLSGATLVLAPPEARRDPAALAELLARHRVTVLNLTPSLLRALLDAAP 727

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1822 AGqevpPLALRHVVFGGEALEVQALRPWFERFGDRapRLVNMYGITETTVHVTYRPLSLADLDGGaASPIGEPIPDLSWY 1901
Cdd:COG1020    728 EA----LPSLRLVLVGGEALPPELVRRWRARLPGA--RLVNLYGPTETTVDSTYYEVTPPDADGG-SVPIGRPIANTRVY 800

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1902 LLDAGLNPVPRGCIGELYVGGAGLARGYLNRPELSCTRFVADPFSTTGGRLYRTGDLARYRCDGVVEYVGRIDHQVKIRG 1981
Cdd:COG1020    801 VLDAHLQPVPVGVPGELYIGGAGLARGYLNRPELTAERFVADPFGFPGARLYRTGDLARWLPDGNLEFLGRADDQVKIRG 880

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1982 FRIELGEIEARLLAQPGVAEAVVLPHE-GPGATQLVGYVVTQAAPSDPAALRdtlRQALKASLPEHMVPAHLLFLERLPL 2060
Cdd:COG1020    881 FRIELGEIEAALLQHPGVREAVVVAREdAPGDKRLVAYVVPEAGAAAAAALL---RLALALLLPPYMVPAAVVLLLPLPL 957

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2061 TANGKLDRRALPAPDASRLQRDYTAPRSELEQRLAAIWADVLKLGRVGLDDNFFELGGDSIISIQVVSRARQAGIRLAPR 2140
Cdd:COG1020    958 TGNGKLDRLALPAPAAAAAAAAAAPPAEEEEEEAALALLLLLVVVVGDDDFFFFGGGLGLLLLLALARAARLLLLLLLLL 1037

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2141 DLFLHQTIRGLAGVAVEGRGLACAEQGPISGSTPLLPIQQMFFELDIPRRQHWNQSVLLEPGQALDGTLLETALQALLAH 2220
Cdd:COG1020   1038 LLFLAAAAAAAAAAAAAAAAAAAAPLAAAAAPLPLPPLLLSLLALLLALLLLLALLALLALLLLLLLLLLLLALLLLLAL 1117

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2221 HDALRLGFRLEDGTWRAEHRAVEAGEVLLWQ-------QSVADGQALEALAEQVQRSLDLGSGPLLRALLATLGDGSQRL 2293
Cdd:COG1020   1118 LLALLAALRARRAVRQEGPRLRLLVALAAALalaallaLLLAAAAAAAELLAAAALLLLLALLLLALLLLLLLLLLLLLL 1197

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2294 LLVIHHLVVDGVSWRILLEDLQTAYRQLQAGQAVALPAKTSAFKAWAERLQAHARDGGLEGERGYWLAQLEGVSTELPCD 2373
Cdd:COG1020   1198 LLLLLLLLLLLLLLLLLLLLLLLLLLLAAAAAALLALALLLALLALAALLALAALAALAAALLALALALLALALLLLALA 1277

                         1290      1300      1310      1320
                   ....*....|....*....|....*....|....*....|....*...
gi 2183974163 2374 DREGAQSVRHVRSARTELTEEATRRLLQEAPAAYRTQVNDLLLTALAR 2421
Cdd:COG1020   1278 LLLPALARARAARTARALALLLLLALLLLLALALALLLLLLLLLALLL 1325

EntF

EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites ...

36-1366

0e+00

EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism];

Pssm-ID: 440643 [Multi-domain] Cd Length: 1329 Bit Score: 1101.84 E-value: 0e+00

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163   36 LPIPEVASAFERIPLSYAQERQWFLWQMDPQSAAYNIPSALRLRGELDVEALSASLGAIVERHQSLRTVFV-EDEQLDGF 114
Cdd:COG1020      6 AAALPPAAAAAPLPLSAAQQRLWLLLLLLLGSAAYNLALALLLLGLLLVAALLLLAALLARRRRALRTRLRtRAGRPVQV 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  115 RQQVLASVDVPVPVTLAGDDDAQAQIRAFVESETQQPFDLRNGPLLRARLLRLAADDHVLTLTIHHVAADGWSMRVLVEE 194
Cdd:COG1020     86 IQPVVAAPLPVVVLLVDLEALAEAAAEAAAAAEALAPFDLLRGPLLRLLLLLLLLLLLLLLLALHHIISDGLSDGLLLAE 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  195 LIALYGARRQGIEATLPDLPIQYADYAIWQRHWLEAGERERQLEYWMARLGGGQSVLELPTDRQRPALPSYRGARHELQL 274
Cdd:COG1020    166 LLRLYLAAYAGAPLPLPPLPIQYADYALWQREWLQGEELARQLAYWRQQLAGLPPLLELPTDRPRPAVQSYRGARVSFRL 245

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  275 PQALGRQLQALAQREGTTLFMLLLASFQALLHRYSGQDEIRVGVPVANRNRVETERLIGFFVNTQVLRADLDAQMPFLDL 354
Cdd:COG1020    246 PAELTAALRALARRHGVTLFMVLLAAFALLLARYSGQDDVVVGTPVAGRPRPELEGLVGFFVNTLPLRVDLSGDPSFAEL 325

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  355 LQQTRVAALGAQSHQDLPFEQLVEALQPERSLSHSPLFQAMYNHQNLGSAgrqslAAQLPGLSVEDLSWGAHSAQFDLTL 434
Cdd:COG1020    326 LARVRETLLAAYAHQDLPFERLVEELQPERDLSRNPLFQVMFVLQNAPAD-----ELELPGLTLEPLELDSGTAKFDLTL 400

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  435 DTYESEQGVHAEFTYATDLFEAATVERLARHWRNLLEAVVAEPRRRLGDLPLLDAEERATLLQRSRLPASEYPAGQGVHR 514
Cdd:COG1020    401 TVVETGDGLRLTLEYNTDLFDAATIERMAGHLVTLLEALAADPDQPLGDLPLLTAAERQQLLAEWNATAAPYPADATLHE 480

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  515 LFEAQAGLTPDAPALLFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQY 594
Cdd:COG1020    481 LFEAQAARTPDAVAVVFGDQSLTYAELNARANRLAHHLRALGVGPGDLVGVCLERSLEMVVALLAVLKAGAAYVPLDPAY 560

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  595 PADRLQYMIDDSGLRLLLSQQSVLARLPQSdGLQSLLLDDLErlVHGYPAENPDLPEAPDSLCYAIYTSGSTGQPKGVMV 674
Cdd:COG1020    561 PAERLAYMLEDAGARLVLTQSALAARLPEL-GVPVLALDALA--LAAEPATNPPVPVTPDDLAYVIYTSGSTGRPKGVMV 637

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  675 RHRALTNFVCSIARQPGMLARDRLLSVTTFSFDIFGLELYVPLARGASMLLASREQAQDPEALLDLVERQGVTVLQATPA 754
Cdd:COG1020    638 EHRALVNLLAWMQRRYGLGPGDRVLQFASLSFDASVWEIFGALLSGATLVLAPPEARRDPAALAELLARHRVTVLNLTPS 717

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  755 TWRMLCDSERVDLLRGCTLLCGGEALAEDLAARMRGLSAST--WNLYGPTETTIWSARFRLGEE----ARPFLGGPLENT 828
Cdd:COG1020    718 LLRALLDAAPEALPSLRLVLVGGEALPPELVRRWRARLPGArlVNLYGPTETTVDSTYYEVTPPdadgGSVPIGRPIANT 797

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  829 ALYILDSEMNPCPPGVAGELLIGGDGLARGYHRRPGLTAERFLPDPFAADGSRLYRTGDLARYRADGVIEYLGRIDHQVK 908
Cdd:COG1020    798 RVYVLDAHLQPVPVGVPGELYIGGAGLARGYLNRPELTAERFVADPFGFPGARLYRTGDLARWLPDGNLEFLGRADDQVK 877

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  909 IRGFRIELGEIETRLLEQDSVREAVVVAQPGVAGPT-LVAYLVPTEAALVDAESARQQelrsalknsLLAVLPDYMVPAH 987
Cdd:COG1020    878 IRGFRIELGEIEAALLQHPGVREAVVVAREDAPGDKrLVAYVVPEAGAAAAAALLRLA---------LALLLPPYMVPAA 948

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  988 MLLLENLPLTPNGKINRKALPLPDASAVRDAhVAPEGELERAMAAIWSEVLKLGHIGRDDNFFELGGHSLLVTQVVSRVR 1067
Cdd:COG1020    949 VVLLLPLPLTGNGKLDRLALPAPAAAAAAAA-AAPPAEEEEEEAALALLLLLVVVVGDDDFFFFGGGLGLLLLLALARAA 1027

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1068 RRLDLQVPLRTLFEHSTLRAYAQAVAQLAPAAQGGIVRCARDASPQLSFAQERQWFIWRLDPHSAAYNIPVALRLKGPLR 1147
Cdd:COG1020   1028 RLLLLLLLLLLLFLAAAAAAAAAAAAAAAAAAAAPLAAAAAPLPLPPLLLSLLALLLALLLLLALLALLALLLLLLLLLL 1107

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1148 RDALQGALDLLVQRHETLRTTFVEHDGAPRQVIHPTLPIAIEE---RRPPVAGEDLKGLVETEAHRPFDLQRGPLLRVLL 1224
Cdd:COG1020   1108 LLALLLLLALLLALLAALRARRAVRQEGPRLRLLVALAAALALaalLALLLAAAAAAAELLAAAALLLLLALLLLALLLL 1187

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1225 LPLATDECVLVLTLHHIIADGWSMQVLVDELIRVYAALRHDQPPALAELPIQYADFAAWQRQWMDGGERERQLDYWVSRL 1304
Cdd:COG1020   1188 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLAAAAAALLALALLLALLALAALLALAALAALAAALLALALALL 1267

                         1290      1300      1310      1320      1330      1340
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2183974163 1305 GGEQPLLELPSDRPRPQQQSHRGRRIGIPLPAELAEALRRLAQAEQGTLFMLLLASFQALLH 1366
Cdd:COG1020   1268 ALALLLLALALLLPALARARAARTARALALLLLLALLLLLALALALLLLLLLLLALLLLALL 1329

PRK12316

peptide synthase; Provisional

30-1100

0e+00

peptide synthase; Provisional

Pssm-ID: 237054 [Multi-domain] Cd Length: 5163 Bit Score: 969.43 E-value: 0e+00

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163   30 GVTPANLPI-----------PEVASAFERI-PLSYAQERQWFLWQMDPQSAAYNIPSALRLRGeLDVEALSASLGAIVER 97
Cdd:PRK12316  4073 GVTPSDFPLagldqarldalPLPLGEIEDIyPLSPMQQGMLFHSLYEQEAGDYINQMRVDVQG-LDVERFRAAWQAALDR 4151

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163   98 HQSLRTVFVEDEQLDGFRQQVLASVDVPVPV-TLAGDDDAQAQIRAFVESETQQPFDLRNGPLLRARLLRLAADDHVLTL 176
Cdd:PRK12316  4152 HDVLRSGFVWQGELGRPLQVVHKQVSLPFAElDWRGRADLQAALDALAAAERERGFDLQRAPLLRLVLVRTAEGRHHLIY 4231

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  177 TIHHVAADGWSMRVLVEELIALYGARrqgieaTLPDLPIQYADYAIW-QRHWLEAGERerqleYWMARLGGGQSVLELPT 255
Cdd:PRK12316  4232 TNHHILMDGWSNSQLLGEVLERYSGR------PPAQPGGRYRDYIAWlQRQDAAASEA-----FWREQLAALDEPTRLAQ 4300

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  256 DRQRPALPSYRG-ARHELQLPQALGRQLQALAQREGTTLFMLLLASFQALLHRYSGQDEIRVGVPVANR--NRVETERLI 332
Cdd:PRK12316  4301 AIARADLRSANGyGEHVRELDATATARLREFARTQRVTLNTLVQAAWLLLLQRYTGQDTVAFGATVAGRpaELPGIEGQI 4380

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  333 GFFVNTQVLRADLDAQMPFLDLLQQTRVAALGAQSHQDLPFEQLvealQPERSLSHSPLFQAMYNHQN--LGSAGRQSLA 410
Cdd:PRK12316  4381 GLFINTLPVIATPRAQQSVVEWLQQVQRQNLALREHEHTPLYEI----QRWAGQGGEALFDSLLVFENypVSEALQQGAP 4456

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  411 AQLPGLSVEdlSWGAHSAQFDLTLDTYESEQgvhAEFTYATDLFEAATVERLARHWRNLLEAVVAEPRRRLGDLPLLDAE 490
Cdd:PRK12316  4457 GGLRFGEVT--NHEQTNYPLTLAVGLGETLS---LQFSYDRGHFDAATIERLARHLTNLLEAMAEDPQRRLGELQLLEKA 4531

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  491 ERATLLQRSRLPASEYPAGQGVHRLFEAQAGLTPDAPALLFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERG 570
Cdd:PRK12316  4532 EQQRIVALWNRTDAGYPATRCVHQLVAERARMTPDAVAVVFDEEKLTYAELNRRANRLAHALIARGVGPEVLVGIAMERS 4611

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  571 VPMVVALLAVLKAGGAYVPLDPQYPADRLQYMIDDSGLRLLLSQQSVLARLPQSDGLQSLLLDDlERLVHGYPAENPDLP 650
Cdd:PRK12316  4612 AEMMVGLLAVLKAGGAYVPLDPEYPRERLAYMMEDSGAALLLTQSHLLQRLPIPDGLASLALDR-DEDWEGFPAHDPAVR 4690

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  651 EAPDSLCYAIYTSGSTGQPKGVMVRHRALTNFVCSIARQPGMLARDRLLSVTTFSFDIFGLELYVPLARGASMLLASrEQ 730
Cdd:PRK12316  4691 LHPDNLAYVIYTSGSTGRPKGVAVSHGSLVNHLHATGERYELTPDDRVLQFMSFSFDGSHEGLYHPLINGASVVIRD-DS 4769

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  731 AQDPEALLDLVERQGVTVLQATPATWRMLC--DSERVDLLRGCTLLCGGEALAEDLAARMRGL--SASTWNLYGPTETTI 806
Cdd:PRK12316  4770 LWDPERLYAEIHEHRVTVLVFPPVYLQQLAehAERDGEPPSLRVYCFGGEAVAQASYDLAWRAlkPVYLFNGYGPTETTV 4849

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  807 WSARFRL------GEEARPfLGGPLENTALYILDSEMNPCPPGVAGELLIGGDGLARGYHRRPGLTAERFLPDPFAADGS 880
Cdd:PRK12316  4850 TVLLWKArdgdacGAAYMP-IGTPLGNRSGYVLDGQLNPLPVGVAGELYLGGEGVARGYLERPALTAERFVPDPFGAPGG 4928

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  881 RLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQPGVAGPTLVAYLVPTEAALVDAE 960
Cdd:PRK12316  4929 RLYRTGDLARYRADGVIDYLGRVDHQVKIRGFRIELGEIEARLREHPAVREAVVIAQEGAVGKQLVGYVVPQDPALADAD 5008

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  961 sARQQELRSALKNSLLAVLPDYMVPAHMLLLENLPLTPNGKINRKALPLPDASAVRDAHVAPEGELERAMAAIWSEVLKL 1040
Cdd:PRK12316  5009 -EAQAELRDELKAALRERLPEYMVPAHLVFLARMPLTPNGKLDRKALPQPDASLLQQAYVAPRSELEQQVAAIWAEVLQL 5087

                         1050      1060      1070      1080      1090      1100
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1041 GHIGRDDNFFELGGHSLLVTQVVSRVRRRLDLQVPLRTLFEHSTLRAYAQAVAQLAPAAQ 1100
Cdd:PRK12316  5088 ERVGLDDNFFELGGHSLLAIQVTSRIQLELGLELPLRELFQTPTLAAFVELAAAAGSGDD 5147

PRK12316

peptide synthase; Provisional

1148-2152

0e+00

peptide synthase; Provisional

Pssm-ID: 237054 [Multi-domain] Cd Length: 5163 Bit Score: 923.20 E-value: 0e+00

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1148 RDALQGALDllvqRHETLRTTFVEHD--GAPRQVIHP--TLPIAIEE-RRPPVAGEDLKGLVETEAHRPFDLQRGPLLRV 1222
Cdd:PRK12316  4142 RAAWQAALD----RHDVLRSGFVWQGelGRPLQVVHKqvSLPFAELDwRGRADLQAALDALAAAERERGFDLQRAPLLRL 4217

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1223 LLLPLATDECVLVLTLHHIIADGWSMQVLVDELIRVYAAlrhdQPPALAELpiQYADFAAW-QRQwmDGGERERqldYWV 1301
Cdd:PRK12316  4218 VLVRTAEGRHHLIYTNHHILMDGWSNSQLLGEVLERYSG----RPPAQPGG--RYRDYIAWlQRQ--DAAASEA---FWR 4286

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1302 SRLGGEQPLLELPSDRPRPQQQSHRGRRIGIP-LPAELAEALRRLAQAEQGTLFMLLLASFQALLHRYSGQNDIRVGVPI 1380
Cdd:PRK12316  4287 EQLAALDEPTRLAQAIARADLRSANGYGEHVReLDATATARLREFARTQRVTLNTLVQAAWLLLLQRYTGQDTVAFGATV 4366

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1381 ANR--NREETEGLIGFFVNTQVLRAELDGQLPFRELLRQVRQAVVEAQGHQDLPFEQLvdalQPERSLSHAPLFQVMYNH 1458
Cdd:PRK12316  4367 AGRpaELPGIEGQIGLFINTLPVIATPRAQQSVVEWLQQVQRQNLALREHEHTPLYEI----QRWAGQGGEALFDSLLVF 4442

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1459 QRD--DHRGSRFASLGELEVEDLAWDVQTAQFDLTLDTYESsngLLAELTYATDLFDASSAERIAGHWLNLLRSIVARPE 1536
Cdd:PRK12316  4443 ENYpvSEALQQGAPGGLRFGEVTNHEQTNYPLTLAVGLGET---LSLQFSYDRGHFDAATIERLARHLTNLLEAMAEDPQ 4519

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1537 ARIAELKLLDEAEARADLLQWNPGPQDFTPASCLHRLIERQAAERPRATAVVYGERALDYGELNLRANRLAHRLIELGVG 1616
Cdd:PRK12316  4520 RRLGELQLLEKAEQQRIVALWNRTDAGYPATRCVHQLVAERARMTPDAVAVVFDEEKLTYAELNRRANRLAHALIARGVG 4599

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1617 PDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGYMIEDSGIRLLLTQRAARERLPLGEGLPCLLLDAEHEW 1696
Cdd:PRK12316  4600 PEVLVGIAMERSAEMMVGLLAVLKAGGAYVPLDPEYPRERLAYMMEDSGAALLLTQSHLLQRLPIPDGLASLALDRDEDW 4679

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1697 AGYPESDPQSAVGVDNLAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRHWFGFSADDAWSLFHSYAFDFSVWEIFGALLH 1776
Cdd:PRK12316  4680 EGFPAHDPAVRLHPDNLAYVIYTSGSTGRPKGVAVSHGSLVNHLHATGERYELTPDDRVLQFMSFSFDGSHEGLYHPLIN 4759

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1777 GGRLVIVPYETSrSPEDFLRLLCRERVTVLNQTPSAFKQLMQVACAGQEVPPlaLRHVVFGGEALEVQALRPWFERFgdR 1856
Cdd:PRK12316  4760 GASVVIRDDSLW-DPERLYAEIHEHRVTVLVFPPVYLQQLAEHAERDGEPPS--LRVYCFGGEAVAQASYDLAWRAL--K 4834

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1857 APRLVNMYGITETTVHVTYRPLSLADLDGGAASPIGEPIPDLSWYLLDAGLNPVPRGCIGELYVGGAGLARGYLNRPELS 1936
Cdd:PRK12316  4835 PVYLFNGYGPTETTVTVLLWKARDGDACGAAYMPIGTPLGNRSGYVLDGQLNPLPVGVAGELYLGGEGVARGYLERPALT 4914

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1937 CTRFVADPFSTTGGRLYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVVLPHEGPGATQLV 2016
Cdd:PRK12316  4915 AERFVPDPFGAPGGRLYRTGDLARYRADGVIDYLGRVDHQVKIRGFRIELGEIEARLREHPAVREAVVIAQEGAVGKQLV 4994

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2017 GYVVTQA-----APSDPAALRDTLRQALKASLPEHMVPAHLLFLERLPLTANGKLDRRALPAPDASRLQRDYTAPRSELE 2091
Cdd:PRK12316  4995 GYVVPQDpaladADEAQAELRDELKAALRERLPEYMVPAHLVFLARMPLTPNGKLDRKALPQPDASLLQQAYVAPRSELE 5074

                          970       980       990      1000      1010      1020
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2183974163 2092 QRLAAIWADVLKLGRVGLDDNFFELGGDSIISIQVVSRAR-QAGIRLAPRDLFLHQTIRGLA 2152
Cdd:PRK12316  5075 QQVAAIWAEVLQLERVGLDDNFFELGGHSLLAIQVTSRIQlELGLELPLRELFQTPTLAAFV 5136

PRK12467

peptide synthase; Provisional

29-1418

0e+00

peptide synthase; Provisional

Pssm-ID: 237108 [Multi-domain] Cd Length: 3956 Bit Score: 851.76 E-value: 0e+00

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163   29 EGVTPANLPI-----------PEVASAFERI-PLSYAQERQWFLWQMDPQSAAYNIPSALRLRGeLDVEALSASLGAIVE 96
Cdd:PRK12467  2616 RGVTPSDFPLaglsqeqldrlPVAVGDIEDIyPLSPMQQGMLFHTLYEGGAGDYINQMRVDVEG-LDVERFRTAWQAVID 2694

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163   97 RHQSLRTVFVEDEQLDGFRQQVLASVDVPVPVTLAGDD-DAQAQIRAFVESETQQPFDLRNGPLLRARLLRLAADDHVLT 175
Cdd:PRK12467  2695 RHEILRSGFLWDGELEEPLQVVYKQARLPFSRLDWRDRaDLEQALDALAAADRQQGFDLLSAPLLRLTLVRTGEDRHHLI 2774

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  176 LTIHHVAADGWSMRVLVEELIALYGARrqgieaTLPDLPIQYADYAiwqrHWLEAGERERQLEYWMARLGGGQSVLEL-P 254
Cdd:PRK12467  2775 YTNHHILMDGWSGSQLLGEVLQRYFGQ------PPPAREGRYRDYI----AWLQAQDAEASEAFWKEQLAALEEPTRLaR 2844

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  255 TDRQRPALPSYRGARHELQLPQALGRQLQALAQREGTTLFMLLLASFQALLHRYSGQDEIRVGVPVANR--NRVETERLI 332
Cdd:PRK12467  2845 ALYPAPAEAVAGHGAHYLHLDATQTRQLIEFARRHRVTLNTLVQGAWLLLLQRFTGQDTVCFGATVAGRpaQLRGAEQQL 2924

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  333 GFFVNTQVLRADLDAQMPFLDLLQQTRVAALGAQSHQDLP-FEQLVEALQPERSLSHSPLFQAMYnhqnlgsagrqSLAA 411
Cdd:PRK12467  2925 GLFINTLPVIASPRAEQTVSDWLQQVQAQNLALREFEHTPlADIQRWAGQGGEALFDSILVFENY-----------PISE 2993

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  412 QLPGLSVEDLSWGAHSAQ----FDLTLDTYESEQgVHAEFTYATDLFEAATVERLARHWRNLLEAVVAEPRRRLGDLPLL 487
Cdd:PRK12467  2994 ALKQGAPSGLRFGAVSSReqtnYPLTLAVGLGDT-LELEFSYDRQHFDAAAIERLAESFDRLLQAMLNNPAARLGELPTL 3072

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  488 DAEERATLLQRSRLPASEYPAGQGVHRLFEAQAGLTPDAPALLFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIAL 567
Cdd:PRK12467  3073 AAHERRQVLHAWNATAAAYPSERLVHQLIEAQVARTPEAPALVFGDQQLSYAELNRRANRLAHRLIAIGVGPDVLVGVAV 3152

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  568 ERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQYMIDDSGLRLLLSQQSVLARLPQSDGLQSLLLDDLErlVHGYPAENP 647
Cdd:PRK12467  3153 ERSVEMIVALLAVLKAGGAYVPLDPEYPRERLAYMIEDSGVKLLLTQAHLLEQLPAPAGDTALTLDRLD--LNGYSENNP 3230

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  648 DLPEAPDSLCYAIYTSGSTGQPKGVMVRHRALTNFVCSIARQPGMLARDRLLSVTTFSFDIFGLELYVPLARGASMLLAS 727
Cdd:PRK12467  3231 STRVMGENLAYVIYTSGSTGKPKGVGVRHGALANHLCWIAEAYELDANDRVLLFMSFSFDGAQERFLWTLICGGCLVVRD 3310

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  728 REQaQDPEALLDLVERQGVTVLQATPATWRMLC-DSERVDLLRGCTLLCGGEALAEDLAARMRGL--SASTWNLYGPTET 804
Cdd:PRK12467  3311 NDL-WDPEELWQAIHAHRISIACFPPAYLQQFAeDAGGADCASLDIYVFGGEAVPPAAFEQVKRKlkPRGLTNGYGPTEA 3389

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  805 TIWSARFRLGEEARPFL-----GGPLENTALYILDSEMNPCPPGVAGELLIGGDGLARGYHRRPGLTAERFLPDPFAADG 879
Cdd:PRK12467  3390 VVTVTLWKCGGDAVCEApyapiGRPVAGRSIYVLDGQLNPVPVGVAGELYIGGVGLARGYHQRPSLTAERFVADPFSGSG 3469

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  880 SRLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQPGVAGPTLVAYLVPteaalvda 959
Cdd:PRK12467  3470 GRLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIEARLLQHPSVREAVVLARDGAGGKQLVAYVVP-------- 3541

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  960 eSARQQELRSALKNSLLAVLPDYMVPAHMLLLENLPLTPNGKINRKALPLPDASaVRDAHVAPEGELERAMAAIWSEVLK 1039
Cdd:PRK12467  3542 -ADPQGDWRETLRDHLAASLPDYMVPAQLLVLAAMPLGPNGKVDRKALPDPDAK-GSREYVAPRSEVEQQLAAIWADVLG 3619

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1040 LGHIGRDDNFFELGGHSLLVTQVVSRVRRRLDLQVPLRTLFEhstlrayAQAVAQLAPAAQGGIVRCARDASPQlsfaqe 1119
Cdd:PRK12467  3620 VEQVGVTDNFFELGGDSLLALQVLSRIRQSLGLKLSLRDLMS-------APTIAELAGYSPLGDVPVNLLLDLN------ 3686

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1120 rqwfiwrldphsaaynipvalrlkgplrrdALQGALDLLVQRHETLRTTFvehDGAPRQVIhptlpiaIEERRPpvaged 1199
Cdd:PRK12467  3687 ------------------------------RLETGFPALFCRHEGLGTVF---DYEPLAVI-------LEGDRH------ 3720

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1200 lkglveteahrpfdlqrgpllrvlllplatdecVLVLTLHHIIADGWsmqvlvdelirvyaalrhdQPPALAELPIQYAD 1279
Cdd:PRK12467  3721 ---------------------------------VLGLTCRHLLDDGW-------------------QDTSLQAMAVQYAD 3748

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1280 FAAWQRQWMDGGERerqldywvsrlggeqpllelpsdrprpqqqshrgrriGIPLPAELAEALRRLAQAEQgtlfmllla 1359
Cdd:PRK12467  3749 YILWQQAKGPYGLL-------------------------------------GWSLGGTLARLVAELLEREG--------- 3782

                         1370      1380      1390      1400      1410
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2183974163 1360 sfqallhrysgqndirvgvpianrnreETEGLIGFFVNTQVLRAELDGQLPFRELLRQV 1418
Cdd:PRK12467  3783 ---------------------------ESEAFLGLFDNTLPLPDEFVPQAEFLELLRQL 3814

PRK12467

peptide synthase; Provisional

1142-2269

0e+00

peptide synthase; Provisional

Pssm-ID: 237108 [Multi-domain] Cd Length: 3956 Bit Score: 816.32 E-value: 0e+00

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1142 LKGPLRRDALQGALDllvqRHETLRTTFVEHDGA--PRQVIHP--TLPIA-IEERRPPVAGEDLKGLVETEAHRPFDLQR 1216
Cdd:PRK12467  2680 LDVERFRTAWQAVID----RHEILRSGFLWDGELeePLQVVYKqaRLPFSrLDWRDRADLEQALDALAAADRQQGFDLLS 2755

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1217 GPLLRVLLLPLATDECVLVLTLHHIIADGWSMQVLVDELIRVYAAlrhdQPPALAELpiQYADFAAW-QRQwmDGGERER 1295
Cdd:PRK12467  2756 APLLRLTLVRTGEDRHHLIYTNHHILMDGWSGSQLLGEVLQRYFG----QPPPAREG--RYRDYIAWlQAQ--DAEASEA 2827

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1296 qldYWVSRLGG-EQPLLELPSDRPRPQQQSHRGRRIGIPLPAELAEALRRLAQAEQGTLFMLLLASFQALLHRYSGQNDI 1374
Cdd:PRK12467  2828 ---FWKEQLAAlEEPTRLARALYPAPAEAVAGHGAHYLHLDATQTRQLIEFARRHRVTLNTLVQGAWLLLLQRFTGQDTV 2904

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1375 RVGVPIANRNRE--ETEGLIGFFVNTQVLRAELDGQLPFRELLRQVRQAVVEAQGHQdlpfeqlvdalqperslsHAPLF 1452
Cdd:PRK12467  2905 CFGATVAGRPAQlrGAEQQLGLFINTLPVIASPRAEQTVSDWLQQVQAQNLALREFE------------------HTPLA 2966

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1453 QVmynhQRDDHRGSR--FASL-----------------GELEVEDLAWDVQTaQFDLTL-----DTyessngLLAELTYA 1508
Cdd:PRK12467  2967 DI----QRWAGQGGEalFDSIlvfenypisealkqgapSGLRFGAVSSREQT-NYPLTLavglgDT------LELEFSYD 3035

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1509 TDLFDASSAERIAGHWLNLLRSIVARPEARIAELKLLDEAEARADLLQWNPGPQDFTPASCLHRLIERQAAERPRATAVV 1588
Cdd:PRK12467  3036 RQHFDAAAIERLAESFDRLLQAMLNNPAARLGELPTLAAHERRQVLHAWNATAAAYPSERLVHQLIEAQVARTPEAPALV 3115

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1589 YGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGYMIEDSGIRL 1668
Cdd:PRK12467  3116 FGDQQLSYAELNRRANRLAHRLIAIGVGPDVLVGVAVERSVEMIVALLAVLKAGGAYVPLDPEYPRERLAYMIEDSGVKL 3195

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1669 LLTQRAARERLPLGEGLPCLLLDAEHEWaGYPESDPQSAVGVDNLAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRHWFG 1748
Cdd:PRK12467  3196 LLTQAHLLEQLPAPAGDTALTLDRLDLN-GYSENNPSTRVMGENLAYVIYTSGSTGKPKGVGVRHGALANHLCWIAEAYE 3274

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1749 FSADDAWSLFHSYAFDFSVWEIFGALLHGGRLVIVPYETsRSPEDFLRLLCRERVTVLNQTPSAFKQLMQVAcAGQEVPP 1828
Cdd:PRK12467  3275 LDANDRVLLFMSFSFDGAQERFLWTLICGGCLVVRDNDL-WDPEELWQAIHAHRISIACFPPAYLQQFAEDA-GGADCAS 3352

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1829 LalRHVVFGGEALEVQALRPWFERFGDRAprLVNMYGITETTVHVTYRPLSLADLDGGAASPIGEPIPDLSWYLLDAGLN 1908
Cdd:PRK12467  3353 L--DIYVFGGEAVPPAAFEQVKRKLKPRG--LTNGYGPTEAVVTVTLWKCGGDAVCEAPYAPIGRPVAGRSIYVLDGQLN 3428

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1909 PVPRGCIGELYVGGAGLARGYLNRPELSCTRFVADPFSTTGGRLYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGE 1988
Cdd:PRK12467  3429 PVPVGVAGELYIGGVGLARGYHQRPSLTAERFVADPFSGSGGRLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGE 3508

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1989 IEARLLAQPGVAEAVVLPHEGPGATQLVGYVVTQAapsDPAALRDTLRQALKASLPEHMVPAHLLFLERLPLTANGKLDR 2068
Cdd:PRK12467  3509 IEARLLQHPSVREAVVLARDGAGGKQLVAYVVPAD---PQGDWRETLRDHLAASLPDYMVPAQLLVLAAMPLGPNGKVDR 3585

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2069 RALPAPDASrLQRDYTAPRSELEQRLAAIWADVLKLGRVGLDDNFFELGGDSIISIQVVSRARQA-GIRLAPRDLFLHQT 2147
Cdd:PRK12467  3586 KALPDPDAK-GSREYVAPRSEVEQQLAAIWADVLGVEQVGVTDNFFELGGDSLLALQVLSRIRQSlGLKLSLRDLMSAPT 3664

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2148 IRGLAGVAvegrglacaeQGPISGSTPLLPIQqmffeldiprRQHWNQSVLLEPGQALDGTLLETALQALLAHHDA---L 2224
Cdd:PRK12467  3665 IAELAGYS----------PLGDVPVNLLLDLN----------RLETGFPALFCRHEGLGTVFDYEPLAVILEGDRHvlgL 3724

                         1130      1140      1150      1160      1170
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2183974163 2225 RLGFRLEDGtW---RAEHRAVEAGEVLLWQQSVA---------DGQALEALAEQVQR 2269
Cdd:PRK12467  3725 TCRHLLDDG-WqdtSLQAMAVQYADYILWQQAKGpygllgwslGGTLARLVAELLER 3780

A_NRPS_Cytc1-like

similar to adenylation domain of cytotrienin synthetase CytC1; This family of the adenylation ...

1582-2071

0e+00

Pssm-ID: 341298 [Multi-domain] Cd Length: 450 Bit Score: 719.86 E-value: 0e+00

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1582 PRATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGYMI 1661
Cdd:cd17643      1 PEAVAVVDEDRRLTYGELDARANRLARTLRAEGVGPGDRVALALPRSAELIVALLAILKAGGAYVPIDPAYPVERIAFIL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1662 EDSGIRLLLTQraarerlplgeglpcllldaehewagypesdpqsavgVDNLAYVIYTSGSTGKPKGTLLPHGNVLRLFD 1741
Cdd:cd17643     81 ADSGPSLLLTD-------------------------------------PDDLAYVIYTSGSTGRPKGVVVSHANVLALFA 123

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1742 ATRHWFGFSADDAWSLFHSYAFDFSVWEIFGALLHGGRLVIVPYETSRSPEDFLRLLCRERVTVLNQTPSAFKQLMQVAC 1821
Cdd:cd17643    124 ATQRWFGFNEDDVWTLFHSYAFDFSVWEIWGALLHGGRLVVVPYEVARSPEDFARLLRDEGVTVLNQTPSAFYQLVEAAD 203

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1822 AGQEvPPLALRHVVFGGEALEVQALRPWFERFGDRAPRLVNMYGITETTVHVTYRPLSLADLDGGAASPIGEPIPDLSWY 1901
Cdd:cd17643    204 RDGR-DPLALRYVIFGGEALEAAMLRPWAGRFGLDRPQLVNMYGITETTVHVTFRPLDAADLPAAAASPIGRPLPGLRVY 282

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1902 LLDAGLNPVPRGCIGELYVGGAGLARGYLNRPELSCTRFVADPFSTTGGRLYRTGDLARYRCDGVVEYVGRIDHQVKIRG 1981
Cdd:cd17643    283 VLDADGRPVPPGVVGELYVSGAGVARGYLGRPELTAERFVANPFGGPGSRMYRTGDLARRLPDGELEYLGRADEQVKIRG 362

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1982 FRIELGEIEARLLAQPGVAEAVVLPHEG-PGATQLVGYVVTQAAPSDPAAlrdTLRQALKASLPEHMVPAHLLFLERLPL 2060
Cdd:cd17643    363 FRIELGEIEAALATHPSVRDAAVIVREDePGDTRLVAYVVADDGAAADIA---ELRALLKELLPDYMVPARYVPLDALPL 439

                          490
                   ....*....|.
gi 2183974163 2061 TANGKLDRRAL 2071
Cdd:cd17643    440 TVNGKLDRAAL 450

LCL_NRPS-like

LCL-type Condensation (C) domain of non-ribosomal peptide synthetases(NRPSs) and similar ...

1114-1535

0e+00

LCL-type Condensation (C) domain of non-ribosomal peptide synthetases(NRPSs) and similar domains including the C-domain of SgcC5, a free-standing NRPS with both ester- and amide- bond forming activity; LCL-type Condensation (C) domains catalyze peptide bond formation between two L-amino acids, ((L)C(L)). C-domains of NRPSs catalyze peptide bond formation within (usually) large multi-modular enzymatic complexes. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long (with various activities such as antibiotic, antifungal, antitumor and immunosuppression). In addition to the LCL-type, there are various subtypes of C-domains such as the DCL-type which links an L-amino acid to the D-amino acid at the end of a growing peptide, starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and heterocyclization (Cyc) domains which catalyze both peptide bond formation and cyclization of Cys, Ser, or Thr residues. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the epimerization (E) domain, the ester-bond forming C-domain, dual E/C (epimerization and condensation) domains, and the X-domain. Streptomyces globisporus SgcC5 is a free-standing NRPS condensation enzyme (rather than a modular NRPS), which catalyzes the condensation between the SgcC2-tethered (S)-3-chloro-5-hydroxy-beta-tyrosine and (R)-1phenyl-1,2-ethanediol, forming an ester bond, during the synthesis of the chromoprotein enediyne antitumor antibiotic C-1027. It has some acceptor substrate promiscuity as it has been shown to also catalyze the formation of an amide bond between SgcC2-tethered (S)-3-chloro-5-hydroxy-beta-tyrosine and a mimic of the enediyne core acceptor substrate having an amine at its C-2 position. C-domains typically have a conserved HHxxxD motif at the active site; mutations in this motif can abolish or diminish condensation activity. An HHxx[SAG]DGxSx(6)[ED] motif is characteristic of LCL-type C-domains.

Pssm-ID: 380454 [Multi-domain] Cd Length: 427 Bit Score: 645.56 E-value: 0e+00

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1114 LSFAQERQWFIWRLDPHSAAYNIPVALRLKGPLRRDALQGALDLLVQRHETLRTTFVEHDGAPRQVIHPTLPIAIE---- 1189
Cdd:cd19531      4 LSFAQQRLWFLDQLEPGSAAYNIPGALRLRGPLDVAALERALNELVARHEALRTTFVEVDGEPVQVILPPLPLPLPvvdl 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1190 -ERRPPVAGEDLKGLVETEAHRPFDLQRGPLLRVLLLPLATDECVLVLTLHHIIADGWSMQVLVDELIRVYAALRHDQPP 1268
Cdd:cd19531     84 sGLPEAEREAEAQRLAREEARRPFDLARGPLLRATLLRLGEDEHVLLLTMHHIVSDGWSMGVLLRELAALYAAFLAGRPS 163

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1269 ALAELPIQYADFAAWQRQWMDGGERERQLDYWVSRLGGEQPLLELPSDRPRPQQQSHRGRRIGIPLPAELAEALRRLAQA 1348
Cdd:cd19531    164 PLPPLPIQYADYAVWQREWLQGEVLERQLAYWREQLAGAPPVLELPTDRPRPAVQSFRGARVRFTLPAELTAALRALARR 243

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1349 EQGTLFMLLLASFQALLHRYSGQNDIRVGVPIANRNREETEGLIGFFVNTQVLRAELDGQLPFRELLRQVRQAVVEAQGH 1428
Cdd:cd19531    244 EGATLFMTLLAAFQVLLHRYSGQDDIVVGTPVAGRNRAELEGLIGFFVNTLVLRTDLSGDPTFRELLARVRETALEAYAH 323

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1429 QDLPFEQLVDALQPERSLSHAPLFQVMYNHQRDDHRGsrfASLGELEVEDLAWDVQTAQFDLTLDTYESSNGLLAELTYA 1508
Cdd:cd19531    324 QDLPFEKLVEALQPERDLSRSPLFQVMFVLQNAPAAA---LELPGLTVEPLEVDSGTAKFDLTLSLTETDGGLRGSLEYN 400

                          410       420
                   ....*....|....*....|....*..
gi 2183974163 1509 TDLFDASSAERIAGHWLNLLRSIVARP 1535
Cdd:cd19531    401 TDLFDAATIERMAGHFQTLLEAIVADP 427

LCL_NRPS-like

LCL-type Condensation (C) domain of non-ribosomal peptide synthetases(NRPSs) and similar ...

47-477

0e+00

Pssm-ID: 380454 [Multi-domain] Cd Length: 427 Bit Score: 641.71 E-value: 0e+00

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163   47 RIPLSYAQERQWFLWQMDPQSAAYNIPSALRLRGELDVEALSASLGAIVERHQSLRTVFVEDEqlDGFRQQVLASVDVPV 126
Cdd:cd19531      1 PLPLSFAQQRLWFLDQLEPGSAAYNIPGALRLRGPLDVAALERALNELVARHEALRTTFVEVD--GEPVQVILPPLPLPL 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  127 PV---TLAGDDDAQAQIRAFVESETQQPFDLRNGPLLRARLLRLAADDHVLTLTIHHVAADGWSMRVLVEELIALYGARR 203
Cdd:cd19531     79 PVvdlSGLPEAEREAEAQRLAREEARRPFDLARGPLLRATLLRLGEDEHVLLLTMHHIVSDGWSMGVLLRELAALYAAFL 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  204 QGIEATLPDLPIQYADYAIWQRHWLEAGERERQLEYWMARLGGGQSVLELPTDRQRPALPSYRGARHELQLPQALGRQLQ 283
Cdd:cd19531    159 AGRPSPLPPLPIQYADYAVWQREWLQGEVLERQLAYWREQLAGAPPVLELPTDRPRPAVQSFRGARVRFTLPAELTAALR 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  284 ALAQREGTTLFMLLLASFQALLHRYSGQDEIRVGVPVANRNRVETERLIGFFVNTQVLRADLDAQMPFLDLLQQTRVAAL 363
Cdd:cd19531    239 ALARREGATLFMTLLAAFQVLLHRYSGQDDIVVGTPVAGRNRAELEGLIGFFVNTLVLRTDLSGDPTFRELLARVRETAL 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  364 GAQSHQDLPFEQLVEALQPERSLSHSPLFQAMYNHQNLGSAgrqslAAQLPGLSVEDLSWGAHSAQFDLTLDTYESEQGV 443
Cdd:cd19531    319 EAYAHQDLPFEKLVEALQPERDLSRSPLFQVMFVLQNAPAA-----ALELPGLTVEPLEVDSGTAKFDLTLSLTETDGGL 393

                          410       420       430
                   ....*....|....*....|....*....|....
gi 2183974163  444 HAEFTYATDLFEAATVERLARHWRNLLEAVVAEP 477
Cdd:cd19531    394 RGSLEYNTDLFDAATIERMAGHFQTLLEAIVADP 427

entF

enterobactin non-ribosomal peptide synthetase EntF;

41-1167

0e+00

enterobactin non-ribosomal peptide synthetase EntF;

Pssm-ID: 236668 [Multi-domain] Cd Length: 1296 Bit Score: 607.81 E-value: 0e+00

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163   41 VASAFERIPLSYAQERQWFLWQMDPQSAAYNIPSALRLRGELDVEALSASLGAIVERHQSLRTVFVEDEqlDGFRQQVLA 120
Cdd:PRK10252     1 AEPMSQHLPLVAAQPGIWMAEKLSPLPSAWSVAHYVELTGELDAPLLARAVVAGLAEADTLRMRFTEDN--GEVWQWVDP 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  121 SVDVPVP--VTLAGDDDAQAQIRAFVESETQQPFDLRNG-PLLRARLLRLAADDHVLTLTIHHVAADGWSMRVLVEELIA 197
Cdd:PRK10252    79 ALTFPLPeiIDLRTQPDPHAAAQALMQADLQQDLRVDSGkPLVFHQLIQLGDNRWYWYQRYHHLLVDGFSFPAITRRIAA 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  198 LYGARRQGI---EATLPDLPIQYADYAIWQRHwlEAGERERQleYWMARLGGGQSVLELPTDRQRPALPSYRGARHELQL 274
Cdd:PRK10252   159 IYCAWLRGEptpASPFTPFADVVEEYQRYRAS--EAWQRDAA--FWAEQRRQLPPPASLSPAPLPGRSASADILRLKLEF 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  275 PQALGRQLqaLAQREGTTLFMLLLASFQALLHRYSGQDEIRVGVPVANRNRVETERLIGFFVNTQVLRADLDAQMPFLDL 354
Cdd:PRK10252   235 TDGAFRQL--AAQASGVQRPDLALALVALWLGRLCGRMDYAAGFIFMRRLGSAALTATGPVLNVLPLRVHIAAQETLPEL 312

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  355 LQQTRVAALGAQSHQDLPFEQLVEAL---QPERSLsHSPLFQAMYNHQNLGSAGRQSLAAQLPGLSVEDLswgahsaqfd 431
Cdd:PRK10252   313 ATRLAAQLKKMRRHQRYDAEQIVRDSgraAGDEPL-FGPVLNIKVFDYQLDFPGVQAQTHTLATGPVNDL---------- 381

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  432 lTLDTYESEQG-VHAEFTYATDLFEAATVERLARHWRNLLEAVVAEPRRRLGDLPLLDAEERAtllQRSRLPASEYP-AG 509
Cdd:PRK10252   382 -ELALFPDEHGgLSIEILANPQRYDEATLIAHAERLKALIAQFAADPALLCGDVDILLPGEYA---QLAQVNATAVEiPE 457

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  510 QGVHRLFEAQAGLTPDAPALLFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVP 589
Cdd:PRK10252   458 TTLSALVAQQAAKTPDAPALADARYQFSYREMREQVVALANLLRERGVKPGDSVAVALPRSVFLTLALHAIVEAGAAWLP 537

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  590 LDPQYPADRLQYMIDDSGLRLLLSQQSVLARLPQSDGLQSLLLDDLErlvhGYPAENPDLPEAPDSLCYAIYTSGSTGQP 669
Cdd:PRK10252   538 LDTGYPDDRLKMMLEDARPSLLITTADQLPRFADVPDLTSLCYNAPL----APQGAAPLQLSQPHHTAYIIFTSGSTGRP 613

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  670 KGVMVRHRALTNFVCSIARQPGMLARDRLLSVTTFSFDIFGLELYVPLARGASMLLASREQAQDPEALLDLVERQGVTVL 749
Cdd:PRK10252   614 KGVMVGQTAIVNRLLWMQNHYPLTADDVVLQKTPCSFDVSVWEFFWPFIAGAKLVMAEPEAHRDPLAMQQFFAEYGVTTT 693

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  750 QATPATWRMLCDSERVDLLRGCTL-----LCGGEALAEDLAARMRGL-SASTWNLYGPTET----TIWSArfrLGEEARP 819
Cdd:PRK10252   694 HFVPSMLAAFVASLTPEGARQSCAslrqvFCSGEALPADLCREWQQLtGAPLHNLYGPTEAavdvSWYPA---FGEELAA 770

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  820 F------LGGPLENTALYILDSEMNPCPPGVAGELLIGGDGLARGYHRRPGLTAERFLPDPFaADGSRLYRTGDLARYRA 893
Cdd:PRK10252   771 VrgssvpIGYPVWNTGLRILDARMRPVPPGVAGDLYLTGIQLAQGYLGRPDLTASRFIADPF-APGERMYRTGDVARWLD 849

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  894 DGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQPGVAGPT-------LVAYLVPTEAALVDAEsarqqe 966
Cdd:PRK10252   850 DGAVEYLGRSDDQLKIRGQRIELGEIDRAMQALPDVEQAVTHACVINQAAAtggdarqLVGYLVSQSGLPLDTS------ 923

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  967 lrsALKNSLLAVLPDYMVPAHMLLLENLPLTPNGKINRKALPLPDaSAVRDAHVAPEGELERAMAAIWSEVLKLGHIGRD 1046
Cdd:PRK10252   924 ---ALQAQLRERLPPHMVPVVLLQLDQLPLSANGKLDRKALPLPE-LKAQVPGRAPKTGTETIIAAAFSSLLGCDVVDAD 999

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1047 DNFFELGGHSLLVTQVVSRVRRRLDLQVPLRTLFEHSTLRAYAQAVA---QLAPAAQGGIVRCARDAS-PQLSFAQERQW 1122
Cdd:PRK10252  1000 ADFFALGGHSLLAMKLAAQLSRQFARQVTPGQVMVASTVAKLATLLDaeeDESRRLGFGTILPLREGDgPTLFCFHPASG 1079

                         1130      1140      1150      1160      1170
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2183974163 1123 FIW-------RLDPHSAAYNIPvALRLKGPLrrdALQGALDLLVQRH-ETLRT 1167
Cdd:PRK10252  1080 FAWqfsvlsrYLDPQWSIYGIQ-SPRPDGPM---QTATSLDEVCEAHlATLLE 1128

A_NRPS_Ta1_like

cd12116

The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A ...

524-1007

0e+00

The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. This family includes the myxovirescin (TA) antibiotic biosynthetic gene in Myxococcus xanthus; TA production plays a role in predation. It also includes the salinosporamide A polyketide synthase which is involved in the biosynthesis of salinosporamide A, a marine microbial metabolite whose chlorine atom is crucial for potent proteasome inhibition and anticancer activity.

Pssm-ID: 341281 [Multi-domain] Cd Length: 470 Bit Score: 600.05 E-value: 0e+00

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  524 PDAPALLFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQYMI 603
Cdd:cd12116      1 PDATAVRDDDRSLSYAELDERANRLAARLRARGVGPGDRVAVYLPRSARLVAAMLAVLKAGAAYVPLDPDYPADRLRYIL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  604 DDSGLRLLLSQQSVLARLPQSDGLQSLLLDDLerlvhGYPAENPDLPEAPDSLCYAIYTSGSTGQPKGVMVRHRALTNFV 683
Cdd:cd12116     81 EDAEPALVLTDDALPDRLPAGLPVLLLALAAA-----AAAPAAPRTPVSPDDLAYVIYTSGSTGRPKGVVVSHRNLVNFL 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  684 CSIARQPGMLARDRLLSVTTFSFDIFGLELYVPLARGASMLLASREQAQDPEALLDLVERQGVTVLQATPATWRMLCDSE 763
Cdd:cd12116    156 HSMRERLGLGPGDRLLAVTTYAFDISLLELLLPLLAGARVVIAPRETQRDPEALARLIEAHSITVMQATPATWRMLLDAG 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  764 RVDLlRGCTLLCGGEALAEDLAARMRGLSASTWNLYGPTETTIWSARFRLGEEARPF-LGGPLENTALYILDSEMNPCPP 842
Cdd:cd12116    236 WQGR-AGLTALCGGEALPPDLAARLLSRVGSLWNLYGPTETTIWSTAARVTAAAGPIpIGRPLANTQVYVLDAALRPVPP 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  843 GVAGELLIGGDGLARGYHRRPGLTAERFLPDPFAADGSRLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETR 922
Cdd:cd12116    315 GVPGELYIGGDGVAQGYLGRPALTAERFVPDPFAGPGSRLYRTGDLVRRRADGRLEYLGRADGQVKIRGHRIELGEIEAA 394

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  923 LLEQDSVREAVVVAQPGVAGPTLVAYLVPTEAALVDAEsarqqELRSALKNSllavLPDYMVPAHMLLLENLPLTPNGKI 1002
Cdd:cd12116    395 LAAHPGVAQAAVVVREDGGDRRLVAYVVLKAGAAPDAA-----ALRAHLRAT----LPAYMVPSAFVRLDALPLTANGKL 465


                   ....*
gi 2183974163 1003 NRKAL 1007
Cdd:cd12116    466 DRKAL 470

A_NRPS

cd05930

The adenylation domain of nonribosomal peptide synthetases (NRPS); The adenylation (A) domain ...

1582-2071

0e+00

The adenylation domain of nonribosomal peptide synthetases (NRPS); The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.

Pssm-ID: 341253 [Multi-domain] Cd Length: 444 Bit Score: 589.50 E-value: 0e+00

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1582 PRATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGYMI 1661
Cdd:cd05930      1 PDAVAVVDGDQSLTYAELDARANRLARYLRERGVGPGDLVAVLLERSLEMVVAILAVLKAGAAYVPLDPSYPAERLAYIL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1662 EDSGIRLLLTQRaarerlplgeglpcllldaehewagypesdpqsavgvDNLAYVIYTSGSTGKPKGTLLPHGNVLRLFD 1741
Cdd:cd05930     81 EDSGAKLVLTDP-------------------------------------DDLAYVIYTSGSTGKPKGVMVEHRGLVNLLL 123

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1742 ATRHWFGFSADDAWSLFHSYAFDFSVWEIFGALLHGGRLVIVPYETSRSPEDFLRLLCRERVTVLNQTPSAFKQLMQvac 1821
Cdd:cd05930    124 WMQEAYPLTPGDRVLQFTSFSFDVSVWEIFGALLAGATLVVLPEEVRKDPEALADLLAEEGITVLHLTPSLLRLLLQ--- 200

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1822 AGQEVPPLALRHVVFGGEALEVQALRPWFERFGDRapRLVNMYGITETTVHVTYRPLSLADLDGGaASPIGEPIPDLSWY 1901
Cdd:cd05930    201 ELELAALPSLRLVLVGGEALPPDLVRRWRELLPGA--RLVNLYGPTEATVDATYYRVPPDDEEDG-RVPIGRPIPNTRVY 277

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1902 LLDAGLNPVPRGCIGELYVGGAGLARGYLNRPELSCTRFVADPFStTGGRLYRTGDLARYRCDGVVEYVGRIDHQVKIRG 1981
Cdd:cd05930    278 VLDENLRPVPPGVPGELYIGGAGLARGYLNRPELTAERFVPNPFG-PGERMYRTGDLVRWLPDGNLEFLGRIDDQVKIRG 356

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1982 FRIELGEIEARLLAQPGVAEAVVLPHE-GPGATQLVGYVVTQAAPSDPAAlrdTLRQALKASLPEHMVPAHLLFLERLPL 2060
Cdd:cd05930    357 YRIELGEIEAALLAHPGVREAAVVAREdGDGEKRLVAYVVPDEGGELDEE---ELRAHLAERLPDYMVPSAFVVLDALPL 433

                          490
                   ....*....|.
gi 2183974163 2061 TANGKLDRRAL 2071
Cdd:cd05930    434 TPNGKVDRKAL 444

A_NRPS

cd05930

The adenylation domain of nonribosomal peptide synthetases (NRPS); The adenylation (A) domain ...

524-1007

0e+00

Pssm-ID: 341253 [Multi-domain] Cd Length: 444 Bit Score: 583.72 E-value: 0e+00

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  524 PDAPALLFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQYMI 603
Cdd:cd05930      1 PDAVAVVDGDQSLTYAELDARANRLARYLRERGVGPGDLVAVLLERSLEMVVAILAVLKAGAAYVPLDPSYPAERLAYIL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  604 DDSGLRLLLSQqsvlarlpqsdglqslllddlerlvhgypaenpdlpeaPDSLCYAIYTSGSTGQPKGVMVRHRALTNFV 683
Cdd:cd05930     81 EDSGAKLVLTD--------------------------------------PDDLAYVIYTSGSTGKPKGVMVEHRGLVNLL 122

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  684 CSIARQPGMLARDRLLSVTTFSFDIFGLELYVPLARGASMLLASREQAQDPEALLDLVERQGVTVLQATPATWRML---C 760
Cdd:cd05930    123 LWMQEAYPLTPGDRVLQFTSFSFDVSVWEIFGALLAGATLVVLPEEVRKDPEALADLLAEEGITVLHLTPSLLRLLlqeL 202

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  761 DSERVDLLRgcTLLCGGEALAEDLAARMRGLSAST--WNLYGPTETTIWSARFRLGEEARPF----LGGPLENTALYILD 834
Cdd:cd05930    203 ELAALPSLR--LVLVGGEALPPDLVRRWRELLPGArlVNLYGPTEATVDATYYRVPPDDEEDgrvpIGRPIPNTRVYVLD 280

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  835 SEMNPCPPGVAGELLIGGDGLARGYHRRPGLTAERFLPDPFaADGSRLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRI 914
Cdd:cd05930    281 ENLRPVPPGVPGELYIGGAGLARGYLNRPELTAERFVPNPF-GPGERMYRTGDLVRWLPDGNLEFLGRIDDQVKIRGYRI 359

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  915 ELGEIETRLLEQDSVREAVVVAQPGVAG-PTLVAYLVPTEAALVDAEsarqqELRSALKNSllavLPDYMVPAHMLLLEN 993
Cdd:cd05930    360 ELGEIEAALLAHPGVREAAVVAREDGDGeKRLVAYVVPDEGGELDEE-----ELRAHLAER----LPDYMVPSAFVVLDA 430

                          490
                   ....*....|....
gi 2183974163  994 LPLTPNGKINRKAL 1007
Cdd:cd05930    431 LPLTPNGKVDRKAL 444

A_NRPS_Srf_like

cd12117

The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis ...

1572-2071

1.26e-177

The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and, in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. This family includes the adenylation domain of the Bacillus subtilis termination module (Surfactin domain, SrfA-C) which recognizes a specific amino acid building block, which is then activated and transferred to the terminal thiol of the 4'-phosphopantetheine (Ppan) arm of the downstream peptidyl carrier protein (PCP) domain.

Pssm-ID: 341282 [Multi-domain] Cd Length: 483 Bit Score: 555.27 E-value: 1.26e-177

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1572 RLIERQAAERPRATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPR 1651
Cdd:cd12117      1 ELFEEQAARTPDAVAVVYGDRSLTYAELNERANRLARRLRAAGVGPGDVVGVLAERSPELVVALLAVLKAGAAYVPLDPE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1652 YPSDRLGYMIEDSGIRLLLTQRAARERLPlgeGLPCLLLDAEHeWAGYPESDPQSAVGVDNLAYVIYTSGSTGKPKGTLL 1731
Cdd:cd12117     81 LPAERLAFMLADAGAKVLLTDRSLAGRAG---GLEVAVVIDEA-LDAGPAGNPAVPVSPDDLAYVMYTSGSTGRPKGVAV 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1732 PHGNVLRLFDATRhWFGFSADDAWSLFHSYAFDFSVWEIFGALLHGGRLVIVPYETSRSPEDFLRLLCRERVTVLNQTPS 1811
Cdd:cd12117    157 THRGVVRLVKNTN-YVTLGPDDRVLQTSPLAFDASTFEIWGALLNGARLVLAPKGTLLDPDALGALIAEEGVTVLWLTAA 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1812 AFKQLmqvacAGQEVPPLA-LRHVVFGGEALEVQALRPWFERFGDraPRLVNMYGITETTVHVTYRPLSLADLDGGAAsP 1890
Cdd:cd12117    236 LFNQL-----ADEDPECFAgLRELLTGGEVVSPPHVRRVLAACPG--LRLVNGYGPTENTTFTTSHVVTELDEVAGSI-P 307

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1891 IGEPIPDLSWYLLDAGLNPVPRGCIGELYVGGAGLARGYLNRPELSCTRFVADPFsTTGGRLYRTGDLARYRCDGVVEYV 1970
Cdd:cd12117    308 IGRPIANTRVYVLDEDGRPVPPGVPGELYVGGDGLALGYLNRPALTAERFVADPF-GPGERLYRTGDLARWLPDGRLEFL 386

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1971 GRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVVLPHEG-PGATQLVGYVVTQAAPSDpaalrDTLRQALKASLPEHMVP 2049
Cdd:cd12117    387 GRIDDQVKIRGFRIELGEIEAALRAHPGVREAVVVVREDaGGDKRLVAYVVAEGALDA-----AELRAFLRERLPAYMVP 461

                          490       500
                   ....*....|....*....|..
gi 2183974163 2050 AHLLFLERLPLTANGKLDRRAL 2071
Cdd:cd12117    462 AAFVVLDELPLTANGKVDRRAL 483

entF

enterobactin non-ribosomal peptide synthetase EntF;

1114-2152

1.65e-177

enterobactin non-ribosomal peptide synthetase EntF;

Pssm-ID: 236668 [Multi-domain] Cd Length: 1296 Bit Score: 585.47 E-value: 1.65e-177

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1114 LSFAQERQWFIWRLDPHSAAYNIPVALRLKGPLRRDALQGALDLLVQRHETLRTTFVEHDGAPRQVIHPTLPIAIEE--- 1190
Cdd:PRK10252    10 LVAAQPGIWMAEKLSPLPSAWSVAHYVELTGELDAPLLARAVVAGLAEADTLRMRFTEDNGEVWQWVDPALTFPLPEiid 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1191 -RRPPVAGEDLKGLVETEAHRPFDLQRGPLLRVLL-LPLATDECVLVLTLHHIIADGWSMQVLVDELIRVYAALRHDQPP 1268
Cdd:PRK10252    90 lRTQPDPHAAAQALMQADLQQDLRVDSGKPLVFHQlIQLGDNRWYWYQRYHHLLVDGFSFPAITRRIAAIYCAWLRGEPT 169

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1269 ALAELPiQYADFAAWQRQWMDGGERERQLDYWVSRLGGEQPLLELPSDRPRPQQQSHRGRRIGIPLPAELAEALrrLAQA 1348
Cdd:PRK10252   170 PASPFT-PFADVVEEYQRYRASEAWQRDAAFWAEQRRQLPPPASLSPAPLPGRSASADILRLKLEFTDGAFRQL--AAQA 246

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1349 EQGTLFMLLLASFQALLHRYSGQNDIRVGVPIANRNREETEGLIGFFVNTQVLRAELDGQLPFRELLRQVRQAVVEAQGH 1428
Cdd:PRK10252   247 SGVQRPDLALALVALWLGRLCGRMDYAAGFIFMRRLGSAALTATGPVLNVLPLRVHIAAQETLPELATRLAAQLKKMRRH 326

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1429 QDLPFEQLVDAL---QPERSLsHAPLFQVMYNHQRDDHRG--SRFASLGELEVEDLAwdvqtaqFDLTLDtyeSSNGLLA 1503
Cdd:PRK10252   327 QRYDAEQIVRDSgraAGDEPL-FGPVLNIKVFDYQLDFPGvqAQTHTLATGPVNDLE-------LALFPD---EHGGLSI 395

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1504 ELTYATDLFDASSAERIAGHWLNLLRSIVARPEARIAELKLLDEAEArADLLQWNPGPQDFtPASCLHRLIERQAAERPR 1583
Cdd:PRK10252   396 EILANPQRYDEATLIAHAERLKALIAQFAADPALLCGDVDILLPGEY-AQLAQVNATAVEI-PETTLSALVAQQAAKTPD 473

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1584 ATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGYMIED 1663
Cdd:PRK10252   474 APALADARYQFSYREMREQVVALANLLRERGVKPGDSVAVALPRSVFLTLALHAIVEAGAAWLPLDTGYPDDRLKMMLED 553

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1664 SGIRLLLTQRAARERLPLGEGLPCLLLDAehEWAGyPESDPQSAVGVDNLAYVIYTSGSTGKPKGTLLPHGNVLRLFDAT 1743
Cdd:PRK10252   554 ARPSLLITTADQLPRFADVPDLTSLCYNA--PLAP-QGAAPLQLSQPHHTAYIIFTSGSTGRPKGVMVGQTAIVNRLLWM 630

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1744 RHWFGFSADDAWSLFHSYAFDFSVWEIFGALLHGGRLVIVPYETSRSPEDFLRLLCRERVTVLNQTPS---AFkqLMQVA 1820
Cdd:PRK10252   631 QNHYPLTADDVVLQKTPCSFDVSVWEFFWPFIAGAKLVMAEPEAHRDPLAMQQFFAEYGVTTTHFVPSmlaAF--VASLT 708

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1821 CAGQEVPPLALRHVVFGGEALEVQALRPWFERFGdrAPrLVNMYGITETTVHVTYRPLSLADLDG--GAASPIGEPIPDL 1898
Cdd:PRK10252   709 PEGARQSCASLRQVFCSGEALPADLCREWQQLTG--AP-LHNLYGPTEAAVDVSWYPAFGEELAAvrGSSVPIGYPVWNT 785

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1899 SWYLLDAGLNPVPRGCIGELYVGGAGLARGYLNRPELSCTRFVADPFStTGGRLYRTGDLARYRCDGVVEYVGRIDHQVK 1978
Cdd:PRK10252   786 GLRILDARMRPVPPGVAGDLYLTGIQLAQGYLGRPDLTASRFIADPFA-PGERMYRTGDVARWLDDGAVEYLGRSDDQLK 864

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1979 IRGFRIELGEIEARLLAQPGVAEAVVL-------PHEGPGATQLVGYVVTQaapSDPAALRDTLRQALKASLPEHMVPAH 2051
Cdd:PRK10252   865 IRGQRIELGEIDRAMQALPDVEQAVTHacvinqaAATGGDARQLVGYLVSQ---SGLPLDTSALQAQLRERLPPHMVPVV 941

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2052 LLFLERLPLTANGKLDRRALPAPDASRlQRDYTAPRSELEQRLAAIWADVLKLGRVGLDDNFFELGGDSIISIQVVSRAR 2131
Cdd:PRK10252   942 LLQLDQLPLSANGKLDRKALPLPELKA-QVPGRAPKTGTETIIAAAFSSLLGCDVVDADADFFALGGHSLLAMKLAAQLS 1020

                         1050      1060
                   ....*....|....*....|..
gi 2183974163 2132 QA-GIRLAPRDLFLHQTIRGLA 2152
Cdd:PRK10252  1021 RQfARQVTPGQVMVASTVAKLA 1042

A_NRPS_PvdJ-like

cd17649

non-ribosomal peptide synthetase; This family of the adenylation (A) domain of nonribosomal ...

524-1008

1.39e-172

non-ribosomal peptide synthetase; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes pyoverdine biosynthesis protein PvdJ involved in the synthesis of pyoverdine, which consists of a chromophore group attached to a variable peptide chain and comprises around 6-12 amino acids that are specific for each Pseudomonas species, and for which the peptide might be first synthesized before the chromophore assembly. Also included is ornibactin biosynthesis protein OrbI; ornibactin is a tetrapeptide siderophore with an l-ornithine-d-hydroxyaspartate-l-serine-l-ornithine backbone. The adenylation domain at the N-terminal of OrbI possibly initiates the ornibactin with the binding of N5-hydroxyornithine. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.

Pssm-ID: 341304 [Multi-domain] Cd Length: 450 Bit Score: 539.65 E-value: 1.39e-172

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  524 PDAPALLFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQYMI 603
Cdd:cd17649      1 PDAVALVFGDQSLSYAELDARANRLAHRLRALGVGPEVRVGIALERSLEMVVALLAILKAGGAYVPLDPEYPAERLRYML 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  604 DDSGLRLLLSQqsvlarlpqsdglqslllddlerlvhgypaenpdlpeAPDSLCYAIYTSGSTGQPKGVMVRHRALTNFV 683
Cdd:cd17649     81 EDSGAGLLLTH-------------------------------------HPRQLAYVIYTSGSTGTPKGVAVSHGPLAAHC 123

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  684 CSIARQPGMLARDRLLSVTTFSFDIFGLELYVPLARGASMLLASREQAQDPEALLDLVERQGVTVLQATPATWRMLCDSE 763
Cdd:cd17649    124 QATAERYGLTPGDRELQFASFNFDGAHEQLLPPLICGACVVLRPDELWASADELAEMVRELGVTVLDLPPAYLQQLAEEA 203

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  764 RVDL------LRGCTLlcGGEALAEDLAARMRGLSASTWNLYGPTETTI----WSARFRLGEE-ARPFLGGPLENTALYI 832
Cdd:cd17649    204 DRTGdgrppsLRLYIF--GGEALSPELLRRWLKAPVRLFNAYGPTEATVtplvWKCEAGAARAgASMPIGRPLGGRSAYI 281

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  833 LDSEMNPCPPGVAGELLIGGDGLARGYHRRPGLTAERFLPDPFAADGSRLYRTGDLARYRADGVIEYLGRIDHQVKIRGF 912
Cdd:cd17649    282 LDADLNPVPVGVTGELYIGGEGLARGYLGRPELTAERFVPDPFGAPGSRLYRTGDLARWRDDGVIEYLGRVDHQVKIRGF 361

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  913 RIELGEIETRLLEQDSVREAVVVAQPGVAGPTLVAYLVPteaalvdAESARQQELRSALKNSLLAVLPDYMVPAHMLLLE 992
Cdd:cd17649    362 RIELGEIEAALLEHPGVREAAVVALDGAGGKQLVAYVVL-------RAAAAQPELRAQLRTALRASLPDYMVPAHLVFLA 434

                          490
                   ....*....|....*.
gi 2183974163  993 NLPLTPNGKINRKALP 1008
Cdd:cd17649    435 RLPLTPNGKLDRKALP 450

A_NRPS_PvdJ-like

cd17649

non-ribosomal peptide synthetase; This family of the adenylation (A) domain of nonribosomal ...

1582-2072

1.17e-171

Pssm-ID: 341304 [Multi-domain] Cd Length: 450 Bit Score: 536.95 E-value: 1.17e-171

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1582 PRATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGYMI 1661
Cdd:cd17649      1 PDAVALVFGDQSLSYAELDARANRLAHRLRALGVGPEVRVGIALERSLEMVVALLAILKAGGAYVPLDPEYPAERLRYML 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1662 EDSGIRLLLTQRAarerlplgeglpcllldaehewagypesdpqsavgvDNLAYVIYTSGSTGKPKGTLLPHGNVLRLFD 1741
Cdd:cd17649     81 EDSGAGLLLTHHP------------------------------------RQLAYVIYTSGSTGTPKGVAVSHGPLAAHCQ 124

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1742 ATRHWFGFSADDAWSLFHSYAFDFSVWEIFGALLHGGRLVIVPYETSRSPEDFLRLLCRERVTVLNQTPSAFKQLMQVAC 1821
Cdd:cd17649    125 ATAERYGLTPGDRELQFASFNFDGAHEQLLPPLICGACVVLRPDELWASADELAEMVRELGVTVLDLPPAYLQQLAEEAD 204

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1822 AGQEVPPLALRHVVFGGEALEVQALRPWFERfgdrAPRLVNMYGITETTVHVTYRPLSLADLDGGAASPIGEPIPDLSWY 1901
Cdd:cd17649    205 RTGDGRPPSLRLYIFGGEALSPELLRRWLKA----PVRLFNAYGPTEATVTPLVWKCEAGAARAGASMPIGRPLGGRSAY 280

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1902 LLDAGLNPVPRGCIGELYVGGAGLARGYLNRPELSCTRFVADPFSTTGGRLYRTGDLARYRCDGVVEYVGRIDHQVKIRG 1981
Cdd:cd17649    281 ILDADLNPVPVGVTGELYIGGEGLARGYLGRPELTAERFVPDPFGAPGSRLYRTGDLARWRDDGVIEYLGRVDHQVKIRG 360

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1982 FRIELGEIEARLLAQPGVAEAVVLPHEGPGATQLVGYVVTQAAPSDPaALRDTLRQALKASLPEHMVPAHLLFLERLPLT 2061
Cdd:cd17649    361 FRIELGEIEAALLEHPGVREAAVVALDGAGGKQLVAYVVLRAAAAQP-ELRAQLRTALRASLPDYMVPAHLVFLARLPLT 439

                          490
                   ....*....|.
gi 2183974163 2062 ANGKLDRRALP 2072
Cdd:cd17649    440 PNGKLDRKALP 450

PRK05691

peptide synthase; Validated

1127-2156

2.02e-168

peptide synthase; Validated

Pssm-ID: 235564 [Multi-domain] Cd Length: 4334 Bit Score: 587.91 E-value: 2.02e-168

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1127 LDPHSAAYNIPVALRLKGPLRRDALQGALDLLVQRHETLRTTFVEHDG-APRQVIHPTLPIAIEE---RRPPVAGED--L 1200
Cdd:PRK05691  3273 LEPGTGLYYMQDRYRINSALDPERFAQAWQAVVARHEALRASFSWNAGeTMLQVIHKPGRTPIDYldwRGLPEDGQEqrL 3352

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1201 KGLVETEAHRPFDLQRGPLLRVLLLPLATDECVLVLTLHHIIADGWSMQVLVDELIRVYAALRHDQPPALAELPiQYADF 1280
Cdd:PRK05691  3353 QALHKQEREAGFDLLNQPPFHLRLIRVDEARYWFMMSNHHILIDAWCRSLLMNDFFEIYTALGEGREAQLPVPP-RYRDY 3431

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1281 AAW-QRQwmdGGERERQldYWVSRLGGEQPLLELPSDRP--RPQQQSHRGRRIG---IPLPAELAEALRRLAQAEQGTLF 1354
Cdd:PRK05691  3432 IGWlQRQ---DLAQARQ--WWQDNLRGFERPTPIPSDRPflREHAGDSGGMVVGdcyTRLDAADGARLRELAQAHQLTVN 3506

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1355 MLLLASFQALLHRYSGQNDIRVGVPIANRNRE--ETEGLIGFFVNTQVLRAEL--DGQ-LPFRELLRQVRQAVVEAQGHQ 1429
Cdd:PRK05691  3507 TFAQAAWALVLRRYSGDRDVLFGVTVAGRPVSmpQMQRTVGLFINSIALRVQLpaAGQrCSVRQWLQGLLDSNMELREYE 3586

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1430 DLPfeqLVDALQPERSLSHAPLFQVMYNHQRDDHRGSRFASLGELEVEDLAWDVQTaQFDLTLDTYESSNgLLAELTYAT 1509
Cdd:PRK05691  3587 YLP---LVAIQECSELPKGQPLFDSLFVFENAPVEVSVLDRAQSLNASSDSGRTHT-NFPLTAVCYPGDD-LGLHLSYDQ 3661

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1510 DLFDASSAERIAGHWLNLLRSIVARPEARIAELKLLDEAEARADLLQWNPGPQDFTPASCLHRLIERQAAERPRATAVVY 1589
Cdd:PRK05691  3662 RYFDAPTVERLLGEFKRLLLALVQGFHGDLSELPLLGEQERDFLLDGCNRSERDYPLEQSYVRLFEAQVAAHPQRIAASC 3741

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1590 GERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGYMIEDSGIRLL 1669
Cdd:PRK05691  3742 LDQQWSYAELNRAANRLGHALRAAGVGVDQPVALLAERGLDLLGMIVGSFKAGAGYLPLDPGLPAQRLQRIIELSRTPVL 3821

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1670 LTQRAARER-LPLGEGLPC-----LLLDAEHEWAGYPESDPQSAVGVDNLAYVIYTSGSTGKPKGTLLPHGNVLRLFDAT 1743
Cdd:PRK05691  3822 VCSAACREQaRALLDELGCanrprLLVWEEVQAGEVASHNPGIYSGPDNLAYVIYTSGSTGLPKGVMVEQRGMLNNQLSK 3901

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1744 RHWFGFSADDAWSLFHSYAFDFSVWEIFGALLHGGRLVIVPYETSRSPEDFLRLLCRERVTVLNQTPSafkqLMQVACAG 1823
Cdd:PRK05691  3902 VPYLALSEADVIAQTASQSFDISVWQFLAAPLFGARVEIVPNAIAHDPQGLLAHVQAQGITVLESVPS----LIQGMLAE 3977

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1824 QEVPPLALRHVVFGGEALEVQALRPWFERFGDRAprLVNMYGITETTVHVTYRPLSLADLDGgAASPIGEPIPDLSWYLL 1903
Cdd:PRK05691  3978 DRQALDGLRWMLPTGEAMPPELARQWLQRYPQIG--LVNAYGPAECSDDVAFFRVDLASTRG-SYLPIGSPTDNNRLYLL 4054

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1904 DAGLNPVPRGCIGELYVGGAGLARGYLNRPELSCTRFVADPFSTTGGRLYRTGDLARYRCDGVVEYVGRIDHQVKIRGFR 1983
Cdd:PRK05691  4055 DEALELVPLGAVGELCVAGTGVGRGYVGDPLRTALAFVPHPFGAPGERLYRTGDLARRRSDGVLEYVGRIDHQVKIRGYR 4134

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1984 IELGEIEARLLAQPGVAEAVVLPHEGPGATQLVGYVVTQAAPSDPAALRDTLRQALKASLPEHMVPAHLLFLERLPLTAN 2063
Cdd:PRK05691  4135 IELGEIEARLHEQAEVREAAVAVQEGVNGKHLVGYLVPHQTVLAQGALLERIKQRLRAELPDYMVPLHWLWLDRLPLNAN 4214

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2064 GKLDRRALPAPDASRLQ-RDYTAPRSELEQRLAAIWADVLKLGRVGLDDNFFELGGDSIISIQVVSRARQAGIRLAP-RD 2141
Cdd:PRK05691  4215 GKLDRKALPALDIGQLQsQAYLAPRNELEQTLATIWADVLKVERVGVHDNFFELGGHSLLATQIASRVQKALQRNVPlRA 4294

                         1050      1060
                   ....*....|....*....|..
gi 2183974163 2142 LF-------LHQTIRGLAGVAV 2156
Cdd:PRK05691  4295 MFecstveeLAEYIEGLAGSAI 4316

A_NRPS_AB3403-like

cd17646

Peptide Synthetase; The adenylation (A) domain of NRPS recognizes a specific amino acid or ...

1571-2071

4.16e-168

Peptide Synthetase; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.

Pssm-ID: 341301 [Multi-domain] Cd Length: 488 Bit Score: 528.38 E-value: 4.16e-168

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1571 HRLIERQAAERPRATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDP 1650
Cdd:cd17646      1 HALVAEQAARTPDAPAVVDEGRTLTYRELDERANRLAHLLRARGVGPEDRVAVLLPRSADLVVALLAVLKAGAAYLPLDP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1651 RYPSDRLGYMIEDSGIRLLLTQRAARERLPlgeGLPCLLLDAEHEWAGYPESDPQSAVGVDNLAYVIYTSGSTGKPKGTL 1730
Cdd:cd17646     81 GYPADRLAYMLADAGPAVVLTTADLAARLP---AGGDVALLGDEALAAPPATPPLVPPRPDNLAYVIYTSGSTGRPKGVM 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1731 LPHGNVLRLFDATRHWFGFSADDAWSLFHSYAFDFSVWEIFGALLHGGRLVIVPYETSRSPEDFLRLLCRERVTVLNQTP 1810
Cdd:cd17646    158 VTHAGIVNRLLWMQDEYPLGPGDRVLQKTPLSFDVSVWELFWPLVAGARLVVARPGGHRDPAYLAALIREHGVTTCHFVP 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1811 SAFKQLMQVACAGQEVpplALRHVVFGGEALEVQALRPWFERFGdraPRLVNMYGITETTVHVTYRPLSLADLDGGAasP 1890
Cdd:cd17646    238 SMLRVFLAEPAAGSCA---SLRRVFCSGEALPPELAARFLALPG---AELHNLYGPTEAAIDVTHWPVRGPAETPSV--P 309

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1891 IGEPIPDLSWYLLDAGLNPVPRGCIGELYVGGAGLARGYLNRPELSCTRFVADPFStTGGRLYRTGDLARYRCDGVVEYV 1970
Cdd:cd17646    310 IGRPVPNTRLYVLDDALRPVPVGVPGELYLGGVQLARGYLGRPALTAERFVPDPFG-PGSRMYRTGDLARWRPDGALEFL 388

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1971 GRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVVLPHEGP-GATQLVGYVVTQAAPSDPAAlrDTLRQALKASLPEHMVP 2049
Cdd:cd17646    389 GRSDDQVKIRGFRVEPGEIEAALAAHPAVTHAVVVARAAPaGAARLVGYVVPAAGAAGPDT--AALRAHLAERLPEYMVP 466

                          490       500
                   ....*....|....*....|..
gi 2183974163 2050 AHLLFLERLPLTANGKLDRRAL 2071
Cdd:cd17646    467 AAFVVLDALPLTANGKLDRAAL 488

PRK05691

peptide synthase; Validated

36-1099

1.19e-167

peptide synthase; Validated

Pssm-ID: 235564 [Multi-domain] Cd Length: 4334 Bit Score: 585.21 E-value: 1.19e-167

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163   36 LPIPevASAFERI-PLSYAQERQWFLWQMDPQSAAYNIPSALRLRGELDVEALSASLGAIVERHQSLRTVFVEDEQldgf 114
Cdd:PRK05691  3247 LPVP--AAEIEDVyPLTPMQEGLLLHTLLEPGTGLYYMQDRYRINSALDPERFAQAWQAVVARHEALRASFSWNAG---- 3320

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  115 rQQVLASVDVPVPVTL------AGDDDAQAQ-IRAFVESETQQPFDLRNGPLLRARLLRLAADDHVLTLTIHHVAADGWS 187
Cdd:PRK05691  3321 -ETMLQVIHKPGRTPIdyldwrGLPEDGQEQrLQALHKQEREAGFDLLNQPPFHLRLIRVDEARYWFMMSNHHILIDAWC 3399

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  188 MRVLVEELIALYGARRQGIEATLPDLPiQYADYAIW-QRHWLEAGERerqleYWMARLGGGQSVLELPTDRqrPALPSYR 266
Cdd:PRK05691  3400 RSLLMNDFFEIYTALGEGREAQLPVPP-RYRDYIGWlQRQDLAQARQ-----WWQDNLRGFERPTPIPSDR--PFLREHA 3471

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  267 GARHELQ-------LPQALGRQLQALAQREGTTLFMLLLASFQALLHRYSGQDEIRVGVPVANR--NRVETERLIGFFVN 337
Cdd:PRK05691  3472 GDSGGMVvgdcytrLDAADGARLRELAQAHQLTVNTFAQAAWALVLRRYSGDRDVLFGVTVAGRpvSMPQMQRTVGLFIN 3551

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  338 TQVLRADL---DAQMPFLDLLQQTRVAALGAQSHQDLPfeqLVeALQPERSLSH-SPLFQAMYNHQNlgSAGRQSLAAQL 413
Cdd:PRK05691  3552 SIALRVQLpaaGQRCSVRQWLQGLLDSNMELREYEYLP---LV-AIQECSELPKgQPLFDSLFVFEN--APVEVSVLDRA 3625

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  414 PGLSVEDLSWGAHSaQFDLTLDTYESEQ-GVHaeFTYATDLFEAATVERLARHWRNLLEAVVAEPRRRLGDLPLLDAEER 492
Cdd:PRK05691  3626 QSLNASSDSGRTHT-NFPLTAVCYPGDDlGLH--LSYDQRYFDAPTVERLLGEFKRLLLALVQGFHGDLSELPLLGEQER 3702

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  493 ATLLQRSRLPASEYPAGQGVHRLFEAQAGLTPDAPALLFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVP 572
Cdd:PRK05691  3703 DFLLDGCNRSERDYPLEQSYVRLFEAQVAAHPQRIAASCLDQQWSYAELNRAANRLGHALRAAGVGVDQPVALLAERGLD 3782

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  573 MVVALLAVLKAGGAYVPLDPQYPADRLQYMIDDSGLRLLLSQQS-------VLARLPQSDGLQSLLLDDLERlvHGYPAE 645
Cdd:PRK05691  3783 LLGMIVGSFKAGAGYLPLDPGLPAQRLQRIIELSRTPVLVCSAAcreqaraLLDELGCANRPRLLVWEEVQA--GEVASH 3860

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  646 NPDLPEAPDSLCYAIYTSGSTGQPKGVMVRHRALTNFVCSIARQPGMLARDRLLSVTTFSFDIFGLE-LYVPLArGASML 724
Cdd:PRK05691  3861 NPGIYSGPDNLAYVIYTSGSTGLPKGVMVEQRGMLNNQLSKVPYLALSEADVIAQTASQSFDISVWQfLAAPLF-GARVE 3939

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  725 LASREQAQDPEALLDLVERQGVTVLQATPA-TWRMLC-DSERVDLLRgcTLLCGGEALAEDLAAR--MRGLSASTWNLYG 800
Cdd:PRK05691  3940 IVPNAIAHDPQGLLAHVQAQGITVLESVPSlIQGMLAeDRQALDGLR--WMLPTGEAMPPELARQwlQRYPQIGLVNAYG 4017

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  801 PTETTIWSARFRLGEEAR-----PfLGGPLENTALYILDSEMNPCPPGVAGELLIGGDGLARGYHRRPGLTAERFLPDPF 875
Cdd:PRK05691  4018 PAECSDDVAFFRVDLASTrgsylP-IGSPTDNNRLYLLDEALELVPLGAVGELCVAGTGVGRGYVGDPLRTALAFVPHPF 4096

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  876 AADGSRLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQPGVAGPTLVAYLVPTEAA 955
Cdd:PRK05691  4097 GAPGERLYRTGDLARRRSDGVLEYVGRIDHQVKIRGYRIELGEIEARLHEQAEVREAAVAVQEGVNGKHLVGYLVPHQTV 4176

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  956 LVDAesarqqELRSALKNSLLAVLPDYMVPAHMLLLENLPLTPNGKINRKALPLPDASAVRD-AHVAPEGELERAMAAIW 1034
Cdd:PRK05691  4177 LAQG------ALLERIKQRLRAELPDYMVPLHWLWLDRLPLNANGKLDRKALPALDIGQLQSqAYLAPRNELEQTLATIW 4250

                         1050      1060      1070      1080      1090      1100
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2183974163 1035 SEVLKLGHIGRDDNFFELGGHSLLVTQVVSRVRRRLDLQVPLRTLFEHSTLRAYAQAVAQLAPAA 1099
Cdd:PRK05691  4251 ADVLKVERVGVHDNFFELGGHSLLATQIASRVQKALQRNVPLRAMFECSTVEELAEYIEGLAGSA 4315

A_NRPS_VisG_like

cd17651

similar to adenylation domain of virginiamycin S synthetase; This family of the adenylation (A) ...

1574-2072

1.27e-166

similar to adenylation domain of virginiamycin S synthetase; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes virginiamycin S synthetase (VisG) in Streptomyces virginiae; VisG is involved in virginiamycin S (VS) biosynthesis as the provider of an L-pheGly molecule, a highly specific substrate for the last condensation step by VisF. This family also includes linear gramicidin synthetase B (LgrB) in Brevibacillus brevis. Substrate specificity analysis using residues of the substrate-binding pockets of all 16 adenylation domains has shown good agreement of the substrate amino acids predicted with the sequence of linear gramicidin. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.

Pssm-ID: 341306 [Multi-domain] Cd Length: 491 Bit Score: 524.22 E-value: 1.27e-166

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1574 IERQAAERPRATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYP 1653
Cdd:cd17651      1 FERQAARTPDAPALVAEGRRLTYAELDRRANRLAHRLRARGVGPGDLVALCARRSAELVVALLAILKAGAAYVPLDPAYP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1654 SDRLGYMIEDSGIRLLLTQRAARERLPlGEGLPCLLLDAEhEWAGYPESDPQSAVGVDNLAYVIYTSGSTGKPKGTLLPH 1733
Cdd:cd17651     81 AERLAFMLADAGPVLVLTHPALAGELA-VELVAVTLLDQP-GAAAGADAEPDPALDADDLAYVIYTSGSTGRPKGVVMPH 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1734 GNVLRLFDATRHWFGFSADDAWSLFHSYAFDFSVWEIFGALLHGGRLVIVPYETSRSPEDFLRLLCRERVTVLNQTPSAF 1813
Cdd:cd17651    159 RSLANLVAWQARASSLGPGARTLQFAGLGFDVSVQEIFSTLCAGATLVLPPEEVRTDPPALAAWLDEQRISRVFLPTVAL 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1814 KQLMQVAcAGQEVPPLALRHVVFGGEALEV-QALRPWFERFgdRAPRLVNMYGITETTVhVTYRPLSLADLDGGAASPIG 1892
Cdd:cd17651    239 RALAEHG-RPLGVRLAALRYLLTGGEQLVLtEDLREFCAGL--PGLRLHNHYGPTETHV-VTALSLPGDPAAWPAPPPIG 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1893 EPIPDLSWYLLDAGLNPVPRGCIGELYVGGAGLARGYLNRPELSCTRFVADPFStTGGRLYRTGDLARYRCDGVVEYVGR 1972
Cdd:cd17651    315 RPIDNTRVYVLDAALRPVPPGVPGELYIGGAGLARGYLNRPELTAERFVPDPFV-PGARMYRTGDLARWLPDGELEFLGR 393

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1973 IDHQVKIRGFRIELGEIEARLLAQPGVAEAVVLPHE-GPGATQLVGYVVTQAAPSDPAAlrdTLRQALKASLPEHMVPAH 2051
Cdd:cd17651    394 ADDQVKIRGFRIELGEIEAALARHPGVREAVVLAREdRPGEKRLVAYVVGDPEAPVDAA---ELRAALATHLPEYMVPSA 470

                          490       500
                   ....*....|....*....|.
gi 2183974163 2052 LLFLERLPLTANGKLDRRALP 2072
Cdd:cd17651    471 FVLLDALPLTPNGKLDRRALP 491

AA-adenyl-dom

amino acid adenylation domain; This model represents a domain responsible for the specific ...

1596-2004

9.09e-166

Pssm-ID: 273779 [Multi-domain] Cd Length: 409 Bit Score: 517.97 E-value: 9.09e-166

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1596 YGELNLRANRLAHRLIEL-GVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGYMIEDSGIRLLLTQRA 1674
Cdd:TIGR01733    2 YRELDERANRLARHLRAAgGVGPGDRVAVLLERSAELVVAILAVLKAGAAYVPLDPAYPAERLAFILEDAGARLLLTDSA 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1675 ARERLPlGEGLPCLLLDAEHEWAGYPESD---PQSAVGVDNLAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRHWFGFSA 1751
Cdd:TIGR01733   82 LASRLA-GLVLPVILLDPLELAALDDAPApppPDAPSGPDDLAYVIYTSGSTGRPKGVVVTHRSLVNLLAWLARRYGLDP 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1752 DDAWSLFHSYAFDFSVWEIFGALLHGGRLVIVPYETSRSPEDFLRLLCRER-VTVLNQTPSAFKQLMQVACAgqevPPLA 1830
Cdd:TIGR01733  161 DDRVLQFASLSFDASVEEIFGALLAGATLVVPPEDEERDDAALLAALIAEHpVTVLNLTPSLLALLAAALPP----ALAS 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1831 LRHVVFGGEALEVQALRPWFERFGDRapRLVNMYGITETTVHVTYRPLSLADLDGGAASPIGEPIPDLSWYLLDAGLNPV 1910
Cdd:TIGR01733  237 LRLVILGGEALTPALVDRWRARGPGA--RLINLYGPTETTVWSTATLVDPDDAPRESPVPIGRPLANTRLYVLDDDLRPV 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1911 PRGCIGELYVGGAGLARGYLNRPELSCTRFVADPFSTT-GGRLYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEI 1989
Cdd:TIGR01733  315 PVGVVGELYIGGPGVARGYLNRPELTAERFVPDPFAGGdGARLYRTGDLVRYLPDGNLEFLGRIDDQVKIRGYRIELGEI 394

                          410
                   ....*....|....*
gi 2183974163 1990 EARLLAQPGVAEAVV 2004
Cdd:TIGR01733  395 EAALLRHPGVREAVV 409

A_NRPS_Bac

cd17655

bacitracin synthetase and related proteins; This family of the adenylation (A) domain of ...

1572-2075

1.91e-165

bacitracin synthetase and related proteins; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes bacitracin synthetases 1, 2, and 3 (BA1, also known as ATP-dependent cysteine adenylase or cysteine activase, BA2, also known as ATP-dependent lysine adenylase or lysine activase, and BA3, also known as ATP-dependent isoleucine adenylase or isoleucine activase) in Bacilli. Bacitracin is a mixture of related cyclic peptides used as a polypeptide antibiotic. This family also includes gramicidin synthetase 1 involved in synthesis of the cyclic peptide antibiotic gramicidin S via activation of phenylalanine. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.

Pssm-ID: 341310 [Multi-domain] Cd Length: 490 Bit Score: 520.73 E-value: 1.91e-165

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1572 RLIERQAAERPRATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPR 1651
Cdd:cd17655      1 ELFEEQAEKTPDHTAVVFEDQTLTYRELNERANQLARTLREKGVGPDTIVGIMAERSLEMIVGILGILKAGGAYLPIDPD 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1652 YPSDRLGYMIEDSGIRLLLTQRAARERLpLGEGLpCLLLDaEHEWAGYPESDPQSAVGVDNLAYVIYTSGSTGKPKGTLL 1731
Cdd:cd17655     81 YPEERIQYILEDSGADILLTQSHLQPPI-AFIGL-IDLLD-EDTIYHEESENLEPVSKSDDLAYVIYTSGSTGKPKGVMI 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1732 PHGNVLRLFDATRHWFGFSADDAWSLFHSYAFDFSVWEIFGALLHGGRLVIVPYETSRSPEDFLRLLCRERVTVLNQTPS 1811
Cdd:cd17655    158 EHRGVVNLVEWANKVIYQGEHLRVALFASISFDASVTEIFASLLSGNTLYIVRKETVLDGQALTQYIRQNRITIIDLTPA 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1812 AFKQLMQVacagQEVPPLALRHVVFGGEALEVQALRPWFERFGDrAPRLVNMYGITETTVHVTYRPLSLADlDGGAASPI 1891
Cdd:cd17655    238 HLKLLDAA----DDSEGLSLKHLIVGGEALSTELAKKIIELFGT-NPTITNAYGPTETTVDASIYQYEPET-DQQVSVPI 311

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1892 GEPIPDLSWYLLDAGLNPVPRGCIGELYVGGAGLARGYLNRPELSCTRFVADPFsTTGGRLYRTGDLARYRCDGVVEYVG 1971
Cdd:cd17655    312 GKPLGNTRIYILDQYGRPQPVGVAGELYIGGEGVARGYLNRPELTAEKFVDDPF-VPGERMYRTGDLARWLPDGNIEFLG 390

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1972 RIDHQVKIRGFRIELGEIEARLLAQPGVAEAVVLPHEG-PGATQLVGYVVtqaapSDPAALRDTLRQALKASLPEHMVPA 2050
Cdd:cd17655    391 RIDHQVKIRGYRIELGEIEARLLQHPDIKEAVVIARKDeQGQNYLCAYIV-----SEKELPVAQLREFLARELPDYMIPS 465

                          490       500
                   ....*....|....*....|....*
gi 2183974163 2051 HLLFLERLPLTANGKLDRRALPAPD 2075
Cdd:cd17655    466 YFIKLDEIPLTPNGKVDRKALPEPD 490

A_NRPS_Bac

cd17655

bacitracin synthetase and related proteins; This family of the adenylation (A) domain of ...

514-1011

5.51e-165

Pssm-ID: 341310 [Multi-domain] Cd Length: 490 Bit Score: 519.58 E-value: 5.51e-165

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  514 RLFEAQAGLTPDAPALLFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQ 593
Cdd:cd17655      1 ELFEEQAEKTPDHTAVVFEDQTLTYRELNERANQLARTLREKGVGPDTIVGIMAERSLEMIVGILGILKAGGAYLPIDPD 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  594 YPADRLQYMIDDSGLRLLLSQQSVLARLpqsDGLQSLLLDDLERLVHGyPAENPDLPEAPDSLCYAIYTSGSTGQPKGVM 673
Cdd:cd17655     81 YPEERIQYILEDSGADILLTQSHLQPPI---AFIGLIDLLDEDTIYHE-ESENLEPVSKSDDLAYVIYTSGSTGKPKGVM 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  674 VRHRALTNFVCSIARQPGMLARDRLLSVTTFSFDIFGLELYVPLARGASMLLASREQAQDPEALLDLVERQGVTVLQATP 753
Cdd:cd17655    157 IEHRGVVNLVEWANKVIYQGEHLRVALFASISFDASVTEIFASLLSGNTLYIVRKETVLDGQALTQYIRQNRITIIDLTP 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  754 ATWRMLcdsERVDLLRGC---TLLCGGEALAEDLAAR---MRGLSASTWNLYGPTETTIWSARFRLGEEAR----PFLGG 823
Cdd:cd17655    237 AHLKLL---DAADDSEGLslkHLIVGGEALSTELAKKiieLFGTNPTITNAYGPTETTVDASIYQYEPETDqqvsVPIGK 313

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  824 PLENTALYILDSEMNPCPPGVAGELLIGGDGLARGYHRRPGLTAERFLPDPFAAdGSRLYRTGDLARYRADGVIEYLGRI 903
Cdd:cd17655    314 PLGNTRIYILDQYGRPQPVGVAGELYIGGEGVARGYLNRPELTAEKFVDDPFVP-GERMYRTGDLARWLPDGNIEFLGRI 392

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  904 DHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQPGVAG-PTLVAYLVPTeaalvdaESARQQELRSALKNSllavLPDY 982
Cdd:cd17655    393 DHQVKIRGYRIELGEIEARLLQHPDIKEAVVIARKDEQGqNYLCAYIVSE-------KELPVAQLREFLARE----LPDY 461

                          490       500
                   ....*....|....*....|....*....
gi 2183974163  983 MVPAHMLLLENLPLTPNGKINRKALPLPD 1011
Cdd:cd17655    462 MIPSYFIKLDEIPLTPNGKVDRKALPEPD 490

A_NRPS_Ta1_like

cd12116

The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A ...

1582-2071

1.37e-163

Pssm-ID: 341281 [Multi-domain] Cd Length: 470 Bit Score: 514.53 E-value: 1.37e-163

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1582 PRATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGYMI 1661
Cdd:cd12116      1 PDATAVRDDDRSLSYAELDERANRLAARLRARGVGPGDRVAVYLPRSARLVAAMLAVLKAGAAYVPLDPDYPADRLRYIL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1662 EDSGIRLLLTQRAARERLPLGEGLPCLLLDAehewAGYPESDPQSAVGVDNLAYVIYTSGSTGKPKGTLLPHGNVLRLFD 1741
Cdd:cd12116     81 EDAEPALVLTDDALPDRLPAGLPVLLLALAA----AAAAPAAPRTPVSPDDLAYVIYTSGSTGRPKGVVVSHRNLVNFLH 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1742 ATRHWFGFSADDAWSLFHSYAFDFSVWEIFGALLHGGRLVIVPYETSRSPEDFLRLLCRERVTVLNQTPSAFKQLMQvac 1821
Cdd:cd12116    157 SMRERLGLGPGDRLLAVTTYAFDISLLELLLPLLAGARVVIAPRETQRDPEALARLIEAHSITVMQATPATWRMLLD--- 233

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1822 AGQEvpPLALRHVVFGGEALEVQALrpwfERFGDRAPRLVNMYGITETTVHVTYRPLSLADldggAASPIGEPIPDLSWY 1901
Cdd:cd12116    234 AGWQ--GRAGLTALCGGEALPPDLA----ARLLSRVGSLWNLYGPTETTIWSTAARVTAAA----GPIPIGRPLANTQVY 303

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1902 LLDAGLNPVPRGCIGELYVGGAGLARGYLNRPELSCTRFVADPFSTTGGRLYRTGDLARYRCDGVVEYVGRIDHQVKIRG 1981
Cdd:cd12116    304 VLDAALRPVPPGVPGELYIGGDGVAQGYLGRPALTAERFVPDPFAGPGSRLYRTGDLVRRRADGRLEYLGRADGQVKIRG 383

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1982 FRIELGEIEARLLAQPGVAEAVVLPHEGPGATQLVGYVVtqaAPSDPAALRDTLRQALKASLPEHMVPAHLLFLERLPLT 2061
Cdd:cd12116    384 HRIELGEIEAALAAHPGVAQAAVVVREDGGDRRLVAYVV---LKAGAAPDAAALRAHLRATLPAYMVPSAFVRLDALPLT 460

                          490
                   ....*....|
gi 2183974163 2062 ANGKLDRRAL 2071
Cdd:cd12116    461 ANGKLDRKAL 470

A_NRPS_CmdD_like

cd17652

similar to adenylation domain of chondramide synthase cmdD; This family of the adenylation (A) ...

1582-2072

3.44e-163

similar to adenylation domain of chondramide synthase cmdD; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes phosphinothricin tripeptide (PTT, phosphinothricylalanylalanine) synthetase, where PTT is a natural-product antibiotic and potent herbicide that is produced by Streptomyces hygroscopicus. This adenylation domain has been confirmed to directly activate beta-tyrosine, and fluorinated chondramides are produced through precursor-directed biosynthesis. Also included in this family is chondramide synthase D (also known as ATP-dependent phenylalanine adenylase or phenylalanine activase or tyrosine activase). Chondramides A-D are depsipeptide antitumor and antifungal antibiotics produced by C. crocatus, are a class of mixed peptide/polyketide depsipeptides comprised of three amino acids (alanine, N-methyltryptophan, plus the unusual amino acid beta-tyrosine or alpha-methoxy-beta-tyrosine) and a polyketide chain ([E]-7-hydroxy-2,4,6-trimethyloct-4-enoic acid).

Pssm-ID: 341307 [Multi-domain] Cd Length: 436 Bit Score: 511.80 E-value: 3.44e-163

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1582 PRATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGYMI 1661
Cdd:cd17652      1 PDAPAVVFGDETLTYAELNARANRLARLLAARGVGPERLVALALPRSAELVVAILAVLKAGAAYLPLDPAYPAERIAYML 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1662 EDSGIRLLLTQraarerlplgeglpcllldaehewagypesdpqsavgVDNLAYVIYTSGSTGKPKGTLLPHGNVLRLFD 1741
Cdd:cd17652     81 ADARPALLLTT-------------------------------------PDNLAYVIYTSGSTGRPKGVVVTHRGLANLAA 123

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1742 ATRHWFGFSADDAWSLFHSYAFDFSVWEIFGALLHGGRLVIVPYETSRSPEDFLRLLCRERVTVLNQTPSAFKQLmqvac 1821
Cdd:cd17652    124 AQIAAFDVGPGSRVLQFASPSFDASVWELLMALLAGATLVLAPAEELLPGEPLADLLREHRITHVTLPPAALAAL----- 198

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1822 AGQEVPPLalRHVVFGGEALEVQALRPWferfgdrAP--RLVNMYGITETTVHVTYRPLsladLDGGAASPIGEPIPDLS 1899
Cdd:cd17652    199 PPDDLPDL--RTLVVAGEACPAELVDRW-------APgrRMINAYGPTETTVCATMAGP----LPGGGVPPIGRPVPGTR 265

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1900 WYLLDAGLNPVPRGCIGELYVGGAGLARGYLNRPELSCTRFVADPFSTTGGRLYRTGDLARYRCDGVVEYVGRIDHQVKI 1979
Cdd:cd17652    266 VYVLDARLRPVPPGVPGELYIAGAGLARGYLNRPGLTAERFVADPFGAPGSRMYRTGDLARWRADGQLEFLGRADDQVKI 345

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1980 RGFRIELGEIEARLLAQPGVAEAVVLPHE-GPGATQLVGYVVTQAAPSDPAAlrdTLRQALKASLPEHMVPAHLLFLERL 2058
Cdd:cd17652    346 RGFRIELGEVEAALTEHPGVAEAVVVVRDdRPGDKRLVAYVVPAPGAAPTAA---ELRAHLAERLPGYMVPAAFVVLDAL 422

                          490
                   ....*....|....
gi 2183974163 2059 PLTANGKLDRRALP 2072
Cdd:cd17652    423 PLTPNGKLDRRALP 436

A_NRPS_AB3403-like

cd17646

Peptide Synthetase; The adenylation (A) domain of NRPS recognizes a specific amino acid or ...

513-1007

2.84e-162

Pssm-ID: 341301 [Multi-domain] Cd Length: 488 Bit Score: 511.44 E-value: 2.84e-162

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  513 HRLFEAQAGLTPDAPALLFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDP 592
Cdd:cd17646      1 HALVAEQAARTPDAPAVVDEGRTLTYRELDERANRLAHLLRARGVGPEDRVAVLLPRSADLVVALLAVLKAGAAYLPLDP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  593 QYPADRLQYMIDDSGLRLLLSQQSVLARLPQSDGLQSLLLDDLERlvhgYPAENPDLPEAPDSLCYAIYTSGSTGQPKGV 672
Cdd:cd17646     81 GYPADRLAYMLADAGPAVVLTTADLAARLPAGGDVALLGDEALAA----PPATPPLVPPRPDNLAYVIYTSGSTGRPKGV 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  673 MVRHRALTNFVCSIARQPGMLARDRLLSVTTFSFDIFGLELYVPLARGASMLLASREQAQDPEALLDLVERQGVTVLQAT 752
Cdd:cd17646    157 MVTHAGIVNRLLWMQDEYPLGPGDRVLQKTPLSFDVSVWELFWPLVAGARLVVARPGGHRDPAYLAALIREHGVTTCHFV 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  753 PATWRMLCDSERVDLLRGCTL-LCGGEALAEDLAARMRGLS-ASTWNLYGPTETTIWSARFRL-GEEARPFL--GGPLEN 827
Cdd:cd17646    237 PSMLRVFLAEPAAGSCASLRRvFCSGEALPPELAARFLALPgAELHNLYGPTEAAIDVTHWPVrGPAETPSVpiGRPVPN 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  828 TALYILDSEMNPCPPGVAGELLIGGDGLARGYHRRPGLTAERFLPDPFAAdGSRLYRTGDLARYRADGVIEYLGRIDHQV 907
Cdd:cd17646    317 TRLYVLDDALRPVPVGVPGELYLGGVQLARGYLGRPALTAERFVPDPFGP-GSRMYRTGDLARWRPDGALEFLGRSDDQV 395

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  908 KIRGFRIELGEIETRLLEQDSVREAVVVAQ-PGVAGPTLVAYLVPTEaalvDAESARQQELRSALKnsllAVLPDYMVPA 986
Cdd:cd17646    396 KIRGFRVEPGEIEAALAAHPAVTHAVVVARaAPAGAARLVGYVVPAA----GAAGPDTAALRAHLA----ERLPEYMVPA 467

                          490       500
                   ....*....|....*....|.
gi 2183974163  987 HMLLLENLPLTPNGKINRKAL 1007
Cdd:cd17646    468 AFVVLDALPLTANGKLDRAAL 488

A_NRPS_Srf_like

cd12117

The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis ...

514-1007

4.84e-162

Pssm-ID: 341282 [Multi-domain] Cd Length: 483 Bit Score: 510.59 E-value: 4.84e-162

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  514 RLFEAQAGLTPDAPALLFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQ 593
Cdd:cd12117      1 ELFEEQAARTPDAVAVVYGDRSLTYAELNERANRLARRLRAAGVGPGDVVGVLAERSPELVVALLAVLKAGAAYVPLDPE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  594 YPADRLQYMIDDSGLRLLLSQQSVLARLpqsDGLQSLLLDDLERLvhGYPAENPDLPEAPDSLCYAIYTSGSTGQPKGVM 673
Cdd:cd12117     81 LPAERLAFMLADAGAKVLLTDRSLAGRA---GGLEVAVVIDEALD--AGPAGNPAVPVSPDDLAYVMYTSGSTGRPKGVA 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  674 VRHRALTNFVCSiARQPGMLARDRLLSVTTFSFDIFGLELYVPLARGASMLLASREQAQDPEALLDLVERQGVTVLQATP 753
Cdd:cd12117    156 VTHRGVVRLVKN-TNYVTLGPDDRVLQTSPLAFDASTFEIWGALLNGARLVLAPKGTLLDPDALGALIAEEGVTVLWLTA 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  754 ATWRMLCDsERVDLLRGC-TLLCGGEALAEDLAARMRGLSAST--WNLYGPTETTIWSARFRLGEEA----RPFLGGPLE 826
Cdd:cd12117    235 ALFNQLAD-EDPECFAGLrELLTGGEVVSPPHVRRVLAACPGLrlVNGYGPTENTTFTTSHVVTELDevagSIPIGRPIA 313

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  827 NTALYILDSEMNPCPPGVAGELLIGGDGLARGYHRRPGLTAERFLPDPFaADGSRLYRTGDLARYRADGVIEYLGRIDHQ 906
Cdd:cd12117    314 NTRVYVLDEDGRPVPPGVPGELYVGGDGLALGYLNRPALTAERFVADPF-GPGERLYRTGDLARWLPDGRLEFLGRIDDQ 392

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  907 VKIRGFRIELGEIETRLLEQDSVREAVVVAQPGVAGPT-LVAYLVPTEAalVDAEsarqqELRSALKnsllAVLPDYMVP 985
Cdd:cd12117    393 VKIRGFRIELGEIEAALRAHPGVREAVVVVREDAGGDKrLVAYVVAEGA--LDAA-----ELRAFLR----ERLPAYMVP 461

                          490       500
                   ....*....|....*....|..
gi 2183974163  986 AHMLLLENLPLTPNGKINRKAL 1007
Cdd:cd12117    462 AAFVVLDELPLTANGKVDRRAL 483

E_NRPS

Epimerization domain of nonribosomal peptide synthetases (NRPSs); belongs to the ...

2174-2601

2.59e-161

Epimerization domain of nonribosomal peptide synthetases (NRPSs); belongs to the Condensation-domain family; Epimerization (E) domains of nonribosomal peptide synthetases (NRPS) flip the chirality of the end amino acid of a peptide being manufactured by the NRPS. E-domains are homologous to the Condensation (C) domains. NRPSs catalyze peptide bond formation within (usually) large multi-modular enzymatic complexes. Specialized tailoring NRPS domains such as E-domains greatly increase the range of possible peptide products created by the NRPS machinery. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long (with various activities such as antibiotic, antifungal, antitumor and immunosuppression). There are various subtypes of C-domains such as the LCL-type which catalyzes peptide bond formation between two L-amino acids, the DCL-type which links an L-amino acid to the D-amino acid at the end of a growing peptide, starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and heterocyclization (Cyc) domains which catalyze both peptide bond formation and cyclization of Cys, Ser, or Thr residues. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the E-domain, the ester-bond forming C-domain, dual E/C (epimerization and condensation) domains, and the X-domain. C-domains typically have a conserved HHxxxD motif at the active site; mutations in this motif can abolish or diminish condensation activity.

Pssm-ID: 380457 [Multi-domain] Cd Length: 428 Bit Score: 506.02 E-value: 2.59e-161

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2174 PLLPIQQMFFELDIPRRQHWNQSVLLEPGQALDGTLLETALQALLAHHDALRLGFRLEDGTWRAEHRAVEAGEVLLWQQS 2253
Cdd:cd19534      3 PLTPIQRWFFEQNLAGRHHFNQSVLLRVPQGLDPDALRQALRALVEHHDALRMRFRREDGGWQQRIRGDVEELFRLEVVD 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2254 V---ADGQALEALAEQVQRSLDLGSGPLLRALLATLGDGSQRLLLVIHHLVVDGVSWRILLEDLQTAYRQLQAGQAVALP 2330
Cdd:cd19534     83 LsslAQAAAIEALAAEAQSSLDLEEGPLLAAALFDGTDGGDRLLLVIHHLVVDGVSWRILLEDLEAAYEQALAGEPIPLP 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2331 AKTSaFKAWAERLQAHARDGGLEGERGYWLAQLEGVSTELPCDDregAQSVRHVRSARTELTEEATRRLLQEAPAAYRTQ 2410
Cdd:cd19534    163 SKTS-FQTWAELLAEYAQSPALLEELAYWRELPAADYWGLPKDP---EQTYGDARTVSFTLDEEETEALLQEANAAYRTE 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2411 VNDLLLTALARVIGRWTGQADTLIQLEGHGREELFEDIDLTRTVGWFTSLFPLRLSPVA--ELGASIKRIKEQLRAIPHK 2488
Cdd:cd19534    239 INDLLLAALALAFQDWTGRAPPAIFLEGHGREEIDPGLDLSRTVGWFTSMYPVVLDLEAseDLGDTLKRVKEQLRRIPNK 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2489 GLGFGALRYLgSAEDRAALAALPSPRITFNYLGQFDGSFSADssALFRPSADAAGSERDSDAPLDNWLSLNGQVYAGRLG 2568
Cdd:cd19534    319 GIGYGILRYL-TPEGTKRLAFHPQPEISFNYLGQFDQGERDD--ALFVSAVGGGGSDIGPDTPRFALLDINAVVEGGQLV 395

                          410       420       430
                   ....*....|....*....|....*....|...
gi 2183974163 2569 IDWSFSAARFSEASILRLADAYRDELLALIEHC 2601
Cdd:cd19534    396 ITVSYSRNMYHEETIQQLADSYKEALEALIEHC 428

A_NRPS_ApnA-like

cd17644

similar to adenylation domain of anabaenopeptin synthetase (ApnA); This family of the ...

1569-2072

1.78e-157

similar to adenylation domain of anabaenopeptin synthetase (ApnA); This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes Planktothrix agardhii anabaenopeptin synthetase (ApnA A1), which is capable of activating two chemically distinct amino acids (Arg and Tyr). Structural studies show that the architecture of the active site forces Arg to adopt a Tyr-like conformation, thus explaining the bispecificity. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.

Pssm-ID: 341299 [Multi-domain] Cd Length: 465 Bit Score: 496.96 E-value: 1.78e-157

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1569 CLHRLIERQAAERPRATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPL 1648
Cdd:cd17644      1 CIHQLFEEQVERTPDAVAVVFEDQQLTYEELNTKANQLAHYLQSLGVKSESLVGICVERSLEMIIGLLAILKAGGAYVPL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1649 DPRYPSDRLGYMIEDSGIRLLLTQraarerlplgeglpcllldaehewagyPEsdpqsavgvdNLAYVIYTSGSTGKPKG 1728
Cdd:cd17644     81 DPNYPQERLTYILEDAQISVLLTQ---------------------------PE----------NLAYVIYTSGSTGKPKG 123

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1729 TLLPHGNVLRLFDATRHWFGFSADDAWSLFHSYAFDFSVWEIFGALLHGGRLVIVPYETSRSPEDFLRLLCRERVTVLNQ 1808
Cdd:cd17644    124 VMIEHQSLVNLSHGLIKEYGITSSDRVLQFASIAFDVAAEEIYVTLLSGATLVLRPEEMRSSLEDFVQYIQQWQLTVLSL 203

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1809 TPSAFKQLMQVACAGQEVPPLALRHVVFGGEALEVQALRPWFERFGDRaPRLVNMYGITETTVHVTYRPLSLADLDGGAA 1888
Cdd:cd17644    204 PPAYWHLLVLELLLSTIDLPSSLRLVIVGGEAVQPELVRQWQKNVGNF-IQLINVYGPTEATIAATVCRLTQLTERNITS 282

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1889 SPIGEPIPDLSWYLLDAGLNPVPRGCIGELYVGGAGLARGYLNRPELSCTRFVADPF-STTGGRLYRTGDLARYRCDGVV 1967
Cdd:cd17644    283 VPIGRPIANTQVYILDENLQPVPVGVPGELHIGGVGLARGYLNRPELTAEKFISHPFnSSESERLYKTGDLARYLPDGNI 362

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1968 EYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVVLPHEG-PGATQLVGYVVtqaAPSDPAALRDTLRQALKASLPEH 2046
Cdd:cd17644    363 EYLGRIDNQVKIRGFRIELGEIEAVLSQHNDVKTAVVIVREDqPGNKRLVAYIV---PHYEESPSTVELRQFLKAKLPDY 439

                          490       500
                   ....*....|....*....|....*.
gi 2183974163 2047 MVPAHLLFLERLPLTANGKLDRRALP 2072
Cdd:cd17644    440 MIPSAFVVLEELPLTPNGKIDRRALP 465

A_NRPS_VisG_like

cd17651

similar to adenylation domain of virginiamycin S synthetase; This family of the adenylation (A) ...

516-1008

4.36e-156

Pssm-ID: 341306 [Multi-domain] Cd Length: 491 Bit Score: 493.78 E-value: 4.36e-156

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  516 FEAQAGLTPDAPALLFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYP 595
Cdd:cd17651      1 FERQAARTPDAPALVAEGRRLTYAELDRRANRLAHRLRARGVGPGDLVALCARRSAELVVALLAILKAGAAYVPLDPAYP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  596 ADRLQYMIDDSGLRLLLSQQSVLARLPQSDGLQslLLDDLERLVHGYPAEnPDLPEAPDSLCYAIYTSGSTGQPKGVMVR 675
Cdd:cd17651     81 AERLAFMLADAGPVLVLTHPALAGELAVELVAV--TLLDQPGAAAGADAE-PDPALDADDLAYVIYTSGSTGRPKGVVMP 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  676 HRALTNFVCSIARQPGMLARDRLLSVTTFSFDIFGLELYVPLARGASMLLASREQAQDPEALLDLVERQGVTVLQATPAT 755
Cdd:cd17651    158 HRSLANLVAWQARASSLGPGARTLQFAGLGFDVSVQEIFSTLCAGATLVLPPEEVRTDPPALAAWLDEQRISRVFLPTVA 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  756 WRMLCDSERVDLLRGCTL---LCGGEAL--AEDLAARMRGLSASTW-NLYGPTETTIWSARFRLGE----EARPFLGGPL 825
Cdd:cd17651    238 LRALAEHGRPLGVRLAALrylLTGGEQLvlTEDLREFCAGLPGLRLhNHYGPTETHVVTALSLPGDpaawPAPPPIGRPI 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  826 ENTALYILDSEMNPCPPGVAGELLIGGDGLARGYHRRPGLTAERFLPDPFAAdGSRLYRTGDLARYRADGVIEYLGRIDH 905
Cdd:cd17651    318 DNTRVYVLDAALRPVPPGVPGELYIGGAGLARGYLNRPELTAERFVPDPFVP-GARMYRTGDLARWLPDGELEFLGRADD 396

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  906 QVKIRGFRIELGEIETRLLEQDSVREAVVVAQPGVAG-PTLVAYLVPTEAALVDAEsarqqELRSALKnsllAVLPDYMV 984
Cdd:cd17651    397 QVKIRGFRIELGEIEAALARHPGVREAVVLAREDRPGeKRLVAYVVGDPEAPVDAA-----ELRAALA----THLPEYMV 467

                          490       500
                   ....*....|....*....|....
gi 2183974163  985 PAHMLLLENLPLTPNGKINRKALP 1008
Cdd:cd17651    468 PSAFVLLDALPLTPNGKLDRRALP 491

DCL_NRPS

DCL-type Condensation domain of nonribosomal peptide synthetases (NRPSs), which catalyzes the ...

2638-3052

1.52e-155

DCL-type Condensation domain of nonribosomal peptide synthetases (NRPSs), which catalyzes the condensation between a D-aminoacyl/peptidyl-PCP donor and a L-aminoacyl-PCP acceptor; The DCL-type Condensation (C) domain catalyzes the condensation between a D-aminoacyl/peptidyl-PCP donor and a L-aminoacyl-PCP acceptor. This domain is D-specific for the peptidyl donor and L-specific for the aminoacyl acceptor ((D)C(L)); this is in contrast with the standard LCL domains which catalyze peptide bond formation between two L-amino acids, and the restriction of ribosomes to use only L-amino acids. C domains of nonribosomal peptide synthetases (NRPSs) catalyze peptide bond formation within (usually) large multi-modular enzymatic complexes. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long (with various activities such as antibiotic, antifungal, antitumor and immunosuppression). There are various subtypes of C-domains in addition to the LCL- and DCL-types such as starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and heterocyclization (Cyc) domains which catalyze both peptide bond formation and cyclization of Cys, Ser, or Thr residues. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the epimerization (E) domain, the ester-bond forming C-domain, dual E/C (epimerization and condensation) domains, and the X-domain. C-domains typically have a conserved HHxxxD motif at the active site; mutations in this motif can abolish or diminish condensation activity.

Pssm-ID: 380465 [Multi-domain] Cd Length: 423 Bit Score: 489.41 E-value: 1.52e-155

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2638 YPLSPMQQGMLFHSLYQQNSGDYINQMRLDVEG-LDPQRFREAWQAALDAHEVLRSGFLWQGaLEKPLQLVRKRVEVPFS 2716
Cdd:cd19543      2 YPLSPMQEGMLFHSLLDPGSGAYVEQMVITLEGpLDPDRFRAAWQAVVDRHPILRTSFVWEG-LGEPLQVVLKDRKLPWR 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2717 VHDWRDRADLAEALDALAAGEAGL--GFELAEAPLLRLVLVRTGERRHHLIYTNHHILMDGWSNSQLLGEVLQRYR---- 2790
Cdd:cd19543     81 ELDLSHLSEAEQEAELEALAEEDRerGFDLARAPLMRLTLIRLGDDRYRLVWSFHHILLDGWSLPILLKELFAIYAalge 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2791 GETPSR-SDGRYRDYIAWLQRQDAGRTEAFWKQRLQRLGEPTLLVPAFAHGVRGAEGHADRYRQLDVTTSQRLAEFAREQ 2869
Cdd:cd19543    161 GQPPSLpPVRPYRDYIAWLQRQDKEAAEAYWREYLAGFEEPTPLPKELPADADGSYEPGEVSFELSAELTARLQELARQH 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2870 KVTLNTLVQAAWLILLQRFTGQDTVAFGATVSGRPAELRGIEEQIGLFINTLPVVASPCPEQPIGDWLQAVQGENLALRE 2949
Cdd:cd19543    241 GVTLNTVVQGAWALLLSRYSGRDDVVFGTTVSGRPAELPGIETMVGLFINTLPVRVRLDPDQTVLELLKDLQAQQLELRE 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2950 FEHTPLYDIQRWAGQvGEALFDNILVFENYPVSAALAEETPAD-MRIDALSNQEQTHYPLTLLVSAGETLELHYSYSRQA 3028
Cdd:cd19543    321 HEYVPLYEIQAWSEG-KQALFDHLLVFENYPVDESLEEEQDEDgLRITDVSAEEQTNYPLTVVAIPGEELTIKLSYDAEV 399

                          410       420
                   ....*....|....*....|....
gi 2183974163 3029 FDEAAIECLAERLERLLLGMCENP 3052
Cdd:cd19543    400 FDEATIERLLGHLRRVLEQVAANP 423

AA-adenyl-dom

amino acid adenylation domain; This model represents a domain responsible for the specific ...

537-934

1.24e-153

Pssm-ID: 273779 [Multi-domain] Cd Length: 409 Bit Score: 483.31 E-value: 1.24e-153

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  537 SYAELNALANRLAWRLREE-GVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQYMIDDSGLRLLLSQQ 615
Cdd:TIGR01733    1 TYRELDERANRLARHLRAAgGVGPGDRVAVLLERSAELVVAILAVLKAGAAYVPLDPAYPAERLAFILEDAGARLLLTDS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  616 SVLARLPQSDGLQSLLLDDLERLVHGYPAEN-PDLPEAPDSLCYAIYTSGSTGQPKGVMVRHRALTNFVCSIARQPGMLA 694
Cdd:TIGR01733   81 ALASRLAGLVLPVILLDPLELAALDDAPAPPpPDAPSGPDDLAYVIYTSGSTGRPKGVVVTHRSLVNLLAWLARRYGLDP 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  695 RDRLLSVTTFSFDIFGLELYVPLARGASMLLASREQAQDPEALLDLVERQG-VTVLQATPATWRMLCDSERVDLLRGCTL 773
Cdd:TIGR01733  161 DDRVLQFASLSFDASVEEIFGALLAGATLVVPPEDEERDDAALLAALIAEHpVTVLNLTPSLLALLAAALPPALASLRLV 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  774 LCGGEALAEDLAARMRGLSAST--WNLYGPTETTIWSARFRL------GEEARPfLGGPLENTALYILDSEMNPCPPGVA 845
Cdd:TIGR01733  241 ILGGEALTPALVDRWRARGPGArlINLYGPTETTVWSTATLVdpddapRESPVP-IGRPLANTRLYVLDDDLRPVPVGVV 319

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  846 GELLIGGDGLARGYHRRPGLTAERFLPDPFAA-DGSRLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLL 924
Cdd:TIGR01733  320 GELYIGGPGVARGYLNRPELTAERFVPDPFAGgDGARLYRTGDLVRYLPDGNLEFLGRIDDQVKIRGYRIELGEIEAALL 399

                          410
                   ....*....|
gi 2183974163  925 EQDSVREAVV 934
Cdd:TIGR01733  400 RHPGVREAVV 409

LCL_NRPS-like

LCL-type Condensation domain of nonribosomal peptide synthetases (NRPSs) and similar domains; ...

47-477

6.43e-151

LCL-type Condensation domain of nonribosomal peptide synthetases (NRPSs) and similar domains; LCL-type Condensation (C) domains catalyze peptide bond formation between two L-amino acids, ((L)C(L)). C-domains of NRPSs catalyze peptide bond formation within (usually) large multi-modular enzymatic complexes. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long (with various activities such as antibiotic, antifungal, antitumor and immunosuppression). In addition to the LCL-type, there are various subtypes of C-domains such as the DCL-type which links an L-amino acid to the D-amino acid at the end of a growing peptide, starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and heterocyclization (Cyc) domains which catalyze both peptide bond formation and cyclization of Cys, Ser, or Thr residues. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the epimerization (E) domain, the ester-bond forming C-domain, dual E/C (epimerization and condensation) domains, and the X-domain. C-domains typically have a conserved HHxxxD motif at the active site; mutations in this motif can abolish or diminish condensation activity. An HHxx[SAG]DGxSx(6)[ED] motif is characteristic of LCL-type C-domains.

Pssm-ID: 380463 [Multi-domain] Cd Length: 433 Bit Score: 476.53 E-value: 6.43e-151

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163   47 RIPLSYAQERQWFLWQMDPQSAAYNIPSALRLRGELDVEALSASLGAIVERHQSLRTVFVEDEqlDGFRQQVL--ASVDV 124
Cdd:cd19540      1 RIPLSFAQQRLWFLNRLDGPSAAYNIPLALRLTGALDVDALRAALADVVARHESLRTVFPEDD--GGPYQVVLpaAEARP 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  125 PVPVTLAGDDDAQAQIRAFVEsetqQPFDLRNGPLLRARLLRLAADDHVLTLTIHHVAADGWSMRVLVEELIALYGARRQ 204
Cdd:cd19540     79 DLTVVDVTEDELAARLAEAAR----RGFDLTAELPLRARLFRLGPDEHVLVLVVHHIAADGWSMAPLARDLATAYAARRA 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  205 GIEATLPDLPIQYADYAIWQRHWLEAGER-----ERQLEYWMARLGGGQSVLELPTDRQRPALPSYRGARHELQLPQALG 279
Cdd:cd19540    155 GRAPDWAPLPVQYADYALWQRELLGDEDDpdslaARQLAYWRETLAGLPEELELPTDRPRPAVASYRGGTVEFTIDAELH 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  280 RQLQALAQREGTTLFMLLLASFQALLHRYSGQDEIRVGVPVANRNRVETERLIGFFVNTQVLRADLDAQMPFLDLLQQTR 359
Cdd:cd19540    235 ARLAALAREHGATLFMVLHAALAVLLSRLGAGDDIPIGTPVAGRGDEALDDLVGMFVNTLVLRTDVSGDPTFAELLARVR 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  360 VAALGAQSHQDLPFEQLVEALQPERSLSHSPLFQAMYNHQNLGSAgrqslAAQLPGLSVEDLSWGAHSAQFDLTL----- 434
Cdd:cd19540    315 ETDLAAFAHQDVPFERLVEALNPPRSTARHPLFQVMLAFQNTAAA-----TLELPGLTVEPVPVDTGVAKFDLSFtlter 389

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....
gi 2183974163  435 -DTYESEQGVHAEFTYATDLFEAATVERLARHWRNLLEAVVAEP 477
Cdd:cd19540    390 rDADGAPAGLTGELEYATDLFDRSTAERLADRFVRVLEAVVADP 433

A_NRPS_CmdD_like

cd17652

similar to adenylation domain of chondramide synthase cmdD; This family of the adenylation (A) ...

524-1008

8.05e-151

Pssm-ID: 341307 [Multi-domain] Cd Length: 436 Bit Score: 476.36 E-value: 8.05e-151

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  524 PDAPALLFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQYMI 603
Cdd:cd17652      1 PDAPAVVFGDETLTYAELNARANRLARLLAARGVGPERLVALALPRSAELVVAILAVLKAGAAYLPLDPAYPAERIAYML 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  604 DDSGLRLLLSQqsvlarlpqsdglqslllddlerlvhgypaenpdlpeaPDSLCYAIYTSGSTGQPKGVMVRHRALTNFV 683
Cdd:cd17652     81 ADARPALLLTT--------------------------------------PDNLAYVIYTSGSTGRPKGVVVTHRGLANLA 122

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  684 CSIARQPGMLARDRLLSVTTFSFDIFGLELYVPLARGASMLLASREQAQDPEALLDLVERQGVTVLQATPATWRMLcdsE 763
Cdd:cd17652    123 AAQIAAFDVGPGSRVLQFASPSFDASVWELLMALLAGATLVLAPAEELLPGEPLADLLREHRITHVTLPPAALAAL---P 199

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  764 RVDLLRGCTLLCGGEALAEDLAARmrglsastW-------NLYGPTETTIWSARFR-LGEEARPFLGGPLENTALYILDS 835
Cdd:cd17652    200 PDDLPDLRTLVVAGEACPAELVDR--------WapgrrmiNAYGPTETTVCATMAGpLPGGGVPPIGRPVPGTRVYVLDA 271

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  836 EMNPCPPGVAGELLIGGDGLARGYHRRPGLTAERFLPDPFAADGSRLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIE 915
Cdd:cd17652    272 RLRPVPPGVPGELYIAGAGLARGYLNRPGLTAERFVADPFGAPGSRMYRTGDLARWRADGQLEFLGRADDQVKIRGFRIE 351

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  916 LGEIETRLLEQDSVREAVVVAQ-PGVAGPTLVAYLVPTEAALVDAEsarqqELRSALKNSllavLPDYMVPAHMLLLENL 994
Cdd:cd17652    352 LGEVEAALTEHPGVAEAVVVVRdDRPGDKRLVAYVVPAPGAAPTAA-----ELRAHLAER----LPGYMVPAAFVVLDAL 422

                          490
                   ....*....|....
gi 2183974163  995 PLTPNGKINRKALP 1008
Cdd:cd17652    423 PLTPNGKLDRRALP 436

LCL_NRPS-like

LCL-type Condensation domain of nonribosomal peptide synthetases (NRPSs) and similar domains; ...

1114-1535

8.91e-148

Pssm-ID: 380463 [Multi-domain] Cd Length: 433 Bit Score: 467.28 E-value: 8.91e-148

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1114 LSFAQERQWFIWRLDPHSAAYNIPVALRLKGPLRRDALQGALDLLVQRHETLRTTFVEHDGAPRQVIHPTLPIAIEERRP 1193
Cdd:cd19540      4 LSFAQQRLWFLNRLDGPSAAYNIPLALRLTGALDVDALRAALADVVARHESLRTVFPEDDGGPYQVVLPAAEARPDLTVV 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1194 PVAGEDLKGLVETEAHRPFDLQRGPLLRVLLLPLATDECVLVLTLHHIIADGWSMQVLVDELIRVYAALRHDQPPALAEL 1273
Cdd:cd19540     84 DVTEDELAARLAEAARRGFDLTAELPLRARLFRLGPDEHVLVLVVHHIAADGWSMAPLARDLATAYAARRAGRAPDWAPL 163

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1274 PIQYADFAAWQRQWMdGGERE------RQLDYWVSRLGGEQPLLELPSDRPRPQQQSHRGRRIGIPLPAELAEALRRLAQ 1347
Cdd:cd19540    164 PVQYADYALWQRELL-GDEDDpdslaaRQLAYWRETLAGLPEELELPTDRPRPAVASYRGGTVEFTIDAELHARLAALAR 242

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1348 AEQGTLFMLLLASFQALLHRYSGQNDIRVGVPIANRNREETEGLIGFFVNTQVLRAELDGQLPFRELLRQVRQAVVEAQG 1427
Cdd:cd19540    243 EHGATLFMVLHAALAVLLSRLGAGDDIPIGTPVAGRGDEALDDLVGMFVNTLVLRTDVSGDPTFAELLARVRETDLAAFA 322

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1428 HQDLPFEQLVDALQPERSLSHAPLFQVMYNHQRDDHRGsrfASLGELEVEDLAWDVQTAQFDLTL------DTYESSNGL 1501
Cdd:cd19540    323 HQDVPFERLVEALNPPRSTARHPLFQVMLAFQNTAAAT---LELPGLTVEPVPVDTGVAKFDLSFtlterrDADGAPAGL 399

                          410       420       430
                   ....*....|....*....|....*....|....
gi 2183974163 1502 LAELTYATDLFDASSAERIAGHWLNLLRSIVARP 1535
Cdd:cd19540    400 TGELEYATDLFDRSTAERLADRFVRVLEAVVADP 433

A_NRPS_ApnA-like

cd17644

similar to adenylation domain of anabaenopeptin synthetase (ApnA); This family of the ...

512-1008

1.98e-147

Pssm-ID: 341299 [Multi-domain] Cd Length: 465 Bit Score: 468.07 E-value: 1.98e-147

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  512 VHRLFEAQAGLTPDAPALLFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLD 591
Cdd:cd17644      2 IHQLFEEQVERTPDAVAVVFEDQQLTYEELNTKANQLAHYLQSLGVKSESLVGICVERSLEMIIGLLAILKAGGAYVPLD 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  592 PQYPADRLQYMIDDSGLRLLLSQqsvlarlpqsdglqslllddlerlvhgypaenpdlpeaPDSLCYAIYTSGSTGQPKG 671
Cdd:cd17644     82 PNYPQERLTYILEDAQISVLLTQ--------------------------------------PENLAYVIYTSGSTGKPKG 123

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  672 VMVRHRALTNFVCSIARQPGMLARDRLLSVTTFSFDIFGLELYVPLARGASMLLASREQAQDPEALLDLVERQGVTVLQA 751
Cdd:cd17644    124 VMIEHQSLVNLSHGLIKEYGITSSDRVLQFASIAFDVAAEEIYVTLLSGATLVLRPEEMRSSLEDFVQYIQQWQLTVLSL 203

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  752 TPATWRMLCDS---ERVDLLRGCTL-LCGGEALAEDLA---ARMRGLSASTWNLYGPTETTIWSARFRL-----GEEARP 819
Cdd:cd17644    204 PPAYWHLLVLElllSTIDLPSSLRLvIVGGEAVQPELVrqwQKNVGNFIQLINVYGPTEATIAATVCRLtqlteRNITSV 283

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  820 FLGGPLENTALYILDSEMNPCPPGVAGELLIGGDGLARGYHRRPGLTAERFLPDPFA-ADGSRLYRTGDLARYRADGVIE 898
Cdd:cd17644    284 PIGRPIANTQVYILDENLQPVPVGVPGELHIGGVGLARGYLNRPELTAEKFISHPFNsSESERLYKTGDLARYLPDGNIE 363

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  899 YLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQPGVAG-PTLVAYLVPTEAALVDAEsarqqELRSALKNSlla 977
Cdd:cd17644    364 YLGRIDNQVKIRGFRIELGEIEAVLSQHNDVKTAVVIVREDQPGnKRLVAYIVPHYEESPSTV-----ELRQFLKAK--- 435

                          490       500       510
                   ....*....|....*....|....*....|.
gi 2183974163  978 vLPDYMVPAHMLLLENLPLTPNGKINRKALP 1008
Cdd:cd17644    436 -LPDYMIPSAFVVLEELPLTPNGKIDRRALP 465

A_NRPS_Cytc1-like

similar to adenylation domain of cytotrienin synthetase CytC1; This family of the adenylation ...

524-1007

8.31e-146

Pssm-ID: 341298 [Multi-domain] Cd Length: 450 Bit Score: 462.55 E-value: 8.31e-146

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  524 PDAPALLFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQYMI 603
Cdd:cd17643      1 PEAVAVVDEDRRLTYGELDARANRLARTLRAEGVGPGDRVALALPRSAELIVALLAILKAGGAYVPIDPAYPVERIAFIL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  604 DDSGLRLLLSQqsvlarlpqsdglqslllddlerlvhgypaenpdlpeaPDSLCYAIYTSGSTGQPKGVMVRHRALTNFV 683
Cdd:cd17643     81 ADSGPSLLLTD--------------------------------------PDDLAYVIYTSGSTGRPKGVVVSHANVLALF 122

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  684 CSIARQPGMLARDRLLSVTTFSFDIFGLELYVPLARGASMLLASREQAQDPEALLDLVERQGVTVLQATPATWRMLCDSE 763
Cdd:cd17643    123 AATQRWFGFNEDDVWTLFHSYAFDFSVWEIWGALLHGGRLVVVPYEVARSPEDFARLLRDEGVTVLNQTPSAFYQLVEAA 202

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  764 RVDLLRGCTL---LCGGEALA----EDLAARMRGLSASTWNLYGPTETTIWSARFRLGEE-----ARPFLGGPLENTALY 831
Cdd:cd17643    203 DRDGRDPLALryvIFGGEALEaamlRPWAGRFGLDRPQLVNMYGITETTVHVTFRPLDAAdlpaaAASPIGRPLPGLRVY 282

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  832 ILDSEMNPCPPGVAGELLIGGDGLARGYHRRPGLTAERFLPDPFAADGSRLYRTGDLARYRADGVIEYLGRIDHQVKIRG 911
Cdd:cd17643    283 VLDADGRPVPPGVVGELYVSGAGVARGYLGRPELTAERFVANPFGGPGSRMYRTGDLARRLPDGELEYLGRADEQVKIRG 362

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  912 FRIELGEIETRLLEQDSVREAVVVAQPGVAGPT-LVAYLVPTEAalvdaesarQQELRSALKNSLLAVLPDYMVPAHMLL 990
Cdd:cd17643    363 FRIELGEIEAALATHPSVRDAAVIVREDEPGDTrLVAYVVADDG---------AAADIAELRALLKELLPDYMVPARYVP 433

                          490
                   ....*....|....*..
gi 2183974163  991 LENLPLTPNGKINRKAL 1007
Cdd:cd17643    434 LDALPLTVNGKLDRAAL 450

A_NRPS_Sfm_like

cd12115

The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene ...

1570-2071

4.01e-142

The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. This family includes the saframycin A gene cluster from Streptomyces lavendulae which implicates the NRPS system for assembling the unusual tetrapeptidyl skeleton in an iterative manner. It also includes saframycin Mx1 produced by Myxococcus xanthus NRPS.

Pssm-ID: 341280 [Multi-domain] Cd Length: 447 Bit Score: 451.77 E-value: 4.01e-142

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1570 LHRLIERQAAERPRATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLD 1649
Cdd:cd12115      1 LHDLVEAQAARTPDAIALVCGDESLTYAELNRRANRLAARLRAAGVGPESRVGVCLERTPDLVVALLAVLKAGAAYVPLD 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1650 PRYPSDRLGYMIEDSGIRLLLTQRaarerlplgeglpcllldaehewagypesdpqsavgvDNLAYVIYTSGSTGKPKGT 1729
Cdd:cd12115     81 PAYPPERLRFILEDAQARLVLTDP-------------------------------------DDLAYVIYTSGSTGRPKGV 123

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1730 LLPHGNVLRLFDATRHwfGFSADDAWSLFH--SYAFDFSVWEIFGALLHGGRLVIVpyETSRSPEDFLRllcRERVTVLN 1807
Cdd:cd12115    124 AIEHRNAAAFLQWAAA--AFSAEELAGVLAstSICFDLSVFELFGPLATGGKVVLA--DNVLALPDLPA---AAEVTLIN 196

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1808 QTPSAFKQLMQvacagQEVPPLALRHVVFGGEALEVQALRPWFERfgDRAPRLVNMYGITETTVHVTYRPLSLADLDgga 1887
Cdd:cd12115    197 TVPSAAAELLR-----HDALPASVRVVNLAGEPLPRDLVQRLYAR--LQVERVVNLYGPSEDTTYSTVAPVPPGASG--- 266

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1888 ASPIGEPIPDLSWYLLDAGLNPVPRGCIGELYVGGAGLARGYLNRPELSCTRFVADPFSTtGGRLYRTGDLARYRCDGVV 1967
Cdd:cd12115    267 EVSIGRPLANTQAYVLDRALQPVPLGVPGELYIGGAGVARGYLGRPGLTAERFLPDPFGP-GARLYRTGDLVRWRPDGLL 345

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1968 EYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVVLPHE-GPGATQLVGYVVTQAApsdPAALRDTLRQALKASLPEH 2046
Cdd:cd12115    346 EFLGRADNQVKVRGFRIELGEIEAALRSIPGVREAVVVAIGdAAGERRLVAYIVAEPG---AAGLVEDLRRHLGTRLPAY 422

                          490       500
                   ....*....|....*....|....*
gi 2183974163 2047 MVPAHLLFLERLPLTANGKLDRRAL 2071
Cdd:cd12115    423 MVPSRFVRLDALPLTPNGKIDRSAL 447

A_NRPS_SidN3_like

cd05918

The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); ...

1570-2071

3.82e-139

The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. This family of siderophore-synthesizing NRPS includes the third adenylation domain of SidN from the endophytic fungus Neotyphodium lolii, ferrichrome siderophore synthetase, HC-toxin synthetase, and enniatin synthase. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.

Pssm-ID: 341242 [Multi-domain] Cd Length: 481 Bit Score: 444.68 E-value: 3.82e-139

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1570 LHRLIERQAAERPRATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLD 1649
Cdd:cd05918      1 VHDLIEERARSQPDAPAVCAWDGSLTYAELDRLSSRLAHHLRSLGVGPGVFVPLCFEKSKWAVVAMLAVLKAGGAFVPLD 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1650 PRYPSDRLGYMIEDSGIRLLLTqraarerlplgeglpcllldaehewagypeSDPqsavgvDNLAYVIYTSGSTGKPKGT 1729
Cdd:cd05918     81 PSHPLQRLQEILQDTGAKVVLT------------------------------SSP------SDAAYVIFTSGSTGKPKGV 124

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1730 LLPHGNVLRLFDATRHWFGFSADDAWSLFHSYAFDFSVWEIFGALLHGGrLVIVPYETSRsPEDFLRLLCRERVTVLNQT 1809
Cdd:cd05918    125 VIEHRALSTSALAHGRALGLTSESRVLQFASYTFDVSILEIFTTLAAGG-CLCIPSEEDR-LNDLAGFINRLRVTWAFLT 202

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1810 PSAFKQLMQvacagQEVPPLalRHVVFGGEALEVQALRPWferfGDRApRLVNMYGITETTVHVTYRPlslaDLDGGAAS 1889
Cdd:cd05918    203 PSVARLLDP-----EDVPSL--RTLVLGGEALTQSDVDTW----ADRV-RLINAYGPAECTIAATVSP----VVPSTDPR 266

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1890 PIGEPIPDLSWyLLDAGLN--PVPRGCIGELYVGGAGLARGYLNRPELSCTRFVADPF------STTGGRLYRTGDLARY 1961
Cdd:cd05918    267 NIGRPLGATCW-VVDPDNHdrLVPIGAVGELLIEGPILARGYLNDPEKTAAAFIEDPAwlkqegSGRGRRLYRTGDLVRY 345

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1962 RCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAE----AVVLPHEGPGATQLVGYVV-----TQAAPSDPAALR 2032
Cdd:cd05918    346 NPDGSLEYVGRKDTQVKIRGQRVELGEIEHHLRQSLPGAKevvvEVVKPKDGSSSPQLVAFVVldgssSGSGDGDSLFLE 425

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*...
gi 2183974163 2033 DT---------LRQALKASLPEHMVPAHLLFLERLPLTANGKLDRRAL 2071
Cdd:cd05918    426 PSdefralvaeLRSKLRQRLPSYMVPSVFLPLSHLPLTASGKIDRRAL 473

A_NRPS_Sfm_like

cd12115

The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene ...

512-1007

1.34e-138

Pssm-ID: 341280 [Multi-domain] Cd Length: 447 Bit Score: 441.76 E-value: 1.34e-138

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  512 VHRLFEAQAGLTPDAPALLFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLD 591
Cdd:cd12115      1 LHDLVEAQAARTPDAIALVCGDESLTYAELNRRANRLAARLRAAGVGPESRVGVCLERTPDLVVALLAVLKAGAAYVPLD 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  592 PQYPADRLQYMIDDSGLRLLLSQqsvlarlpqsdglqslllddlerlvhgypaenpdlpeaPDSLCYAIYTSGSTGQPKG 671
Cdd:cd12115     81 PAYPPERLRFILEDAQARLVLTD--------------------------------------PDDLAYVIYTSGSTGRPKG 122

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  672 VMVRHRALTNFVCSIARQPGMLARDRLLSVTTFSFDIFGLELYVPLARGASMLLAsreqaQDPEALLDLVERQGVTVLQA 751
Cdd:cd12115    123 VAIEHRNAAAFLQWAAAAFSAEELAGVLASTSICFDLSVFELFGPLATGGKVVLA-----DNVLALPDLPAAAEVTLINT 197

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  752 TPATWRMLCDSErvDLLRGCTLLC-GGEALAEDLAARMRGLS--ASTWNLYGPTETTIWS--ARFRLGEEARPFLGGPLE 826
Cdd:cd12115    198 VPSAAAELLRHD--ALPASVRVVNlAGEPLPRDLVQRLYARLqvERVVNLYGPSEDTTYStvAPVPPGASGEVSIGRPLA 275

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  827 NTALYILDSEMNPCPPGVAGELLIGGDGLARGYHRRPGLTAERFLPDPFAAdGSRLYRTGDLARYRADGVIEYLGRIDHQ 906
Cdd:cd12115    276 NTQAYVLDRALQPVPLGVPGELYIGGAGVARGYLGRPGLTAERFLPDPFGP-GARLYRTGDLVRWRPDGLLEFLGRADNQ 354

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  907 VKIRGFRIELGEIETRLLEQDSVREAVVVAQPGVAG-PTLVAYLVPteaalvdaeSARQQELRSALKNSLLAVLPDYMVP 985
Cdd:cd12115    355 VKVRGFRIELGEIEAALRSIPGVREAVVVAIGDAAGeRRLVAYIVA---------EPGAAGLVEDLRRHLGTRLPAYMVP 425

                          490       500
                   ....*....|....*....|..
gi 2183974163  986 AHMLLLENLPLTPNGKINRKAL 1007
Cdd:cd12115    426 SRFVRLDALPLTPNGKIDRSAL 447

A_NRPS_PpsD_like

cd17650

similar to adenylation domain of plipastatin synthase (PpsD); This family of the adenylation ...

1582-2071

2.59e-135

similar to adenylation domain of plipastatin synthase (PpsD); This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes bacitracin synthetase 1 (BacA) in Bacillus licheniformis, tyrocidine synthetase in Brevibacillus brevis, plipastatin synthase (PpsD, an important antifungal protein) in Bacillus subtilis and mannopeptimycin peptide synthetase (MppB) in Streptomyces hygroscopicus. Plipastatin has strong fungitoxic activity and is involved in inhibition of phospholipase A2 and biofilm formation. Bacitracin, a mixture of related cyclic peptides, is used as a polypeptide antibiotic while function of tyrocidine is thought to be regulation of sporulation. MppB is involved in biosynthetic pathway of mannopeptimycin, a novel class of mannosylated lipoglycopeptides. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.

Pssm-ID: 341305 [Multi-domain] Cd Length: 447 Bit Score: 432.28 E-value: 2.59e-135

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1582 PRATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGYMI 1661
Cdd:cd17650      1 PDAIAVSDATRQLTYRELNERANQLARTLRGLGVAPGSVVGVCADRSLDAIVGLLAVLKAGGAYVPIDPDYPAERLQYML 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1662 EDSGIRLLLTQraarerlplgeglpcllldaehewagyPEsdpqsavgvdNLAYVIYTSGSTGKPKGTLLPHGNVLRLFD 1741
Cdd:cd17650     81 EDSGAKLLLTQ---------------------------PE----------DLAYVIYTSGTTGKPKGVMVEHRNVAHAAH 123

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1742 ATRHWFGFSADDAWSL-FHSYAFDFSVWEIFGALLHGGRLVIVPYETSRSPEDFLRLLCRERVTVLNQTPSAFKQLMQVa 1820
Cdd:cd17650    124 AWRREYELDSFPVRLLqMASFSFDVFAGDFARSLLNGGTLVICPDEVKLDPAALYDLILKSRITLMESTPALIRPVMAY- 202

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1821 CAGQEVPPLALRHVVFGGEALEVQALRPWFERFGDRApRLVNMYGITETTVHVTYRPLSLADLDGGAASPIGEPIPDLSW 1900
Cdd:cd17650    203 VYRNGLDLSAMRLLIVGSDGCKAQDFKTLAARFGQGM-RIINSYGVTEATIDSTYYEEGRDPLGDSANVPIGRPLPNTAM 281

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1901 YLLDAGLNPVPRGCIGELYVGGAGLARGYLNRPELSCTRFVADPFStTGGRLYRTGDLARYRCDGVVEYVGRIDHQVKIR 1980
Cdd:cd17650    282 YVLDERLQPQPVGVAGELYIGGAGVARGYLNRPELTAERFVENPFA-PGERMYRTGDLARWRADGNVELLGRVDHQVKIR 360

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1981 GFRIELGEIEARLLAQPGVAEAVV-LPHEGPGATQLVGYVVTQAAPsDPAALRDTLRQalkaSLPEHMVPAHLLFLERLP 2059
Cdd:cd17650    361 GFRIELGEIESQLARHPAIDEAVVaVREDKGGEARLCAYVVAAATL-NTAELRAFLAK----ELPSYMIPSYYVQLDALP 435

                          490
                   ....*....|..
gi 2183974163 2060 LTANGKLDRRAL 2071
Cdd:cd17650    436 LTPNGKVDRRAL 447

A_NRPS_PpsD_like

cd17650

similar to adenylation domain of plipastatin synthase (PpsD); This family of the adenylation ...

524-1007

3.85e-135

Pssm-ID: 341305 [Multi-domain] Cd Length: 447 Bit Score: 431.89 E-value: 3.85e-135

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  524 PDAPALLFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQYMI 603
Cdd:cd17650      1 PDAIAVSDATRQLTYRELNERANQLARTLRGLGVAPGSVVGVCADRSLDAIVGLLAVLKAGGAYVPIDPDYPAERLQYML 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  604 DDSGLRLLLSQqsvlarlpqsdglqslllddlerlvhgypaenpdlpeaPDSLCYAIYTSGSTGQPKGVMVRHRALTNFV 683
Cdd:cd17650     81 EDSGAKLLLTQ--------------------------------------PEDLAYVIYTSGTTGKPKGVMVEHRNVAHAA 122

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  684 CSIARQPGMLARD-RLLSVTTFSFDIFGLELYVPLARGASMLLASREQAQDPEALLDLVERQGVTVLQATPATWRML--- 759
Cdd:cd17650    123 HAWRREYELDSFPvRLLQMASFSFDVFAGDFARSLLNGGTLVICPDEVKLDPAALYDLILKSRITLMESTPALIRPVmay 202

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  760 CDSERVDLLRGCTLLCGGEA--------LAEDLAARMRglsasTWNLYGPTETTIWSARF-----RLGEEARPFLGGPLE 826
Cdd:cd17650    203 VYRNGLDLSAMRLLIVGSDGckaqdfktLAARFGQGMR-----IINSYGVTEATIDSTYYeegrdPLGDSANVPIGRPLP 277

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  827 NTALYILDSEMNPCPPGVAGELLIGGDGLARGYHRRPGLTAERFLPDPFAAdGSRLYRTGDLARYRADGVIEYLGRIDHQ 906
Cdd:cd17650    278 NTAMYVLDERLQPQPVGVAGELYIGGAGVARGYLNRPELTAERFVENPFAP-GERMYRTGDLARWRADGNVELLGRVDHQ 356

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  907 VKIRGFRIELGEIETRLLEQDSVREAVVVAQPGVAGPT-LVAYLVPteaalvdAESARQQELRSALKNSllavLPDYMVP 985
Cdd:cd17650    357 VKIRGFRIELGEIESQLARHPAIDEAVVAVREDKGGEArLCAYVVA-------AATLNTAELRAFLAKE----LPSYMIP 425

                          490       500
                   ....*....|....*....|..
gi 2183974163  986 AHMLLLENLPLTPNGKINRKAL 1007
Cdd:cd17650    426 SYYVQLDALPLTPNGKVDRRAL 447

A_NRPS_TlmIV_like

cd12114

The adenylation domain of nonribosomal peptide synthetases (NRPS), including ...

524-1007

1.15e-134

The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. This family includes the TLM biosynthetic gene cluster from Streptoalloteichus that consists of nine NRPS genes; the N-terminal module of TlmVI (NRPS-5) and the starter module of BlmVI (NRPS-5) are comprised of the acyl CoA ligase (AL) and acyl carrier protein (ACP)-like domains, which are thought to be involved in the biosynthesis of the beta-aminoalaninamide moiety.

Pssm-ID: 341279 [Multi-domain] Cd Length: 477 Bit Score: 431.69 E-value: 1.15e-134

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  524 PDAPALLFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQYMI 603
Cdd:cd12114      1 PDATAVICGDGTLTYGELAERARRVAGALKAAGVRPGDLVAVTLPKGPEQVVAVLGILAAGAAYVPVDIDQPAARREAIL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  604 DDSGLRLLLSQQSVLARLPQSDGLQSLLLDDLERlvhgyPAENPDLPEAPDSLCYAIYTSGSTGQPKGVMVRHRALTNFV 683
Cdd:cd12114     81 ADAGARLVLTDGPDAQLDVAVFDVLILDLDALAA-----PAPPPPVDVAPDDLAYVIFTSGSTGTPKGVMISHRAALNTI 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  684 CSIARQPGMLARDRLLSVTTFSFDIFGLELYVPLARGASMLLASREQAQDPEALLDLVERQGVTVLQATPATWRMLCDSE 763
Cdd:cd12114    156 LDINRRFAVGPDDRVLALSSLSFDLSVYDIFGALSAGATLVLPDEARRRDPAHWAELIERHGVTLWNSVPALLEMLLDVL 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  764 RVDLLRGCTL---LCGGEALAEDLAARMRGLSAST--WNLYGPTETTIWSARFRLGEEAR-----PFlGGPLENTALYIL 833
Cdd:cd12114    236 EAAQALLPSLrlvLLSGDWIPLDLPARLRALAPDArlISLGGATEASIWSIYHPIDEVPPdwrsiPY-GRPLANQRYRVL 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  834 DSEMNPCPPGVAGELLIGGDGLARGYHRRPGLTAERFLPDPfaaDGSRLYRTGDLARYRADGVIEYLGRIDHQVKIRGFR 913
Cdd:cd12114    315 DPRGRDCPDWVPGELWIGGRGVALGYLGDPELTAARFVTHP---DGERLYRTGDLGRYRPDGTLEFLGRRDGQVKVRGYR 391

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  914 IELGEIETRLLEQDSVREAVVVAQPGVAGPTLVAYLVPTEaalvDAESARQQELRSALKnsllAVLPDYMVPAHMLLLEN 993
Cdd:cd12114    392 IELGEIEAALQAHPGVARAVVVVLGDPGGKRLAAFVVPDN----DGTPIAPDALRAFLA----QTLPAYMIPSRVIALEA 463

                          490
                   ....*....|....
gi 2183974163  994 LPLTPNGKINRKAL 1007
Cdd:cd12114    464 LPLTANGKVDRAAL 477

A_NRPS_TlmIV_like

cd12114

The adenylation domain of nonribosomal peptide synthetases (NRPS), including ...

1582-2071

4.38e-132

Pssm-ID: 341279 [Multi-domain] Cd Length: 477 Bit Score: 424.38 E-value: 4.38e-132

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1582 PRATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGYMI 1661
Cdd:cd12114      1 PDATAVICGDGTLTYGELAERARRVAGALKAAGVRPGDLVAVTLPKGPEQVVAVLGILAAGAAYVPVDIDQPAARREAIL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1662 EDSGIRLLLTQRAARERLPLGEGLPCLLLDAEHEWAGYPESDPQSavgvDNLAYVIYTSGSTGKPKGTLLPHGNVLRLFD 1741
Cdd:cd12114     81 ADAGARLVLTDGPDAQLDVAVFDVLILDLDALAAPAPPPPVDVAP----DDLAYVIFTSGSTGTPKGVMISHRAALNTIL 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1742 ATRHWFGFSADDAWSLFHSYAFDFSVWEIFGALLHGGRLVIVPYETSRSPEDFLRLLCRERVTVLNQTPSAFKQLMQVAC 1821
Cdd:cd12114    157 DINRRFAVGPDDRVLALSSLSFDLSVYDIFGALSAGATLVLPDEARRRDPAHWAELIERHGVTLWNSVPALLEMLLDVLE 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1822 AGQEVPPlALRHVVFGGEALEVQALRPWFERFGDraPRLVNMYGITETTVHVTYRPLslADLDGGAAS-PIGEPIPDLSW 1900
Cdd:cd12114    237 AAQALLP-SLRLVLLSGDWIPLDLPARLRALAPD--ARLISLGGATEASIWSIYHPI--DEVPPDWRSiPYGRPLANQRY 311

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1901 YLLDAGLNPVPRGCIGELYVGGAGLARGYLNRPELSCTRFVADPfstTGGRLYRTGDLARYRCDGVVEYVGRIDHQVKIR 1980
Cdd:cd12114    312 RVLDPRGRDCPDWVPGELWIGGRGVALGYLGDPELTAARFVTHP---DGERLYRTGDLGRYRPDGTLEFLGRRDGQVKVR 388

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1981 GFRIELGEIEARLLAQPGVAEAVVLPHEGPGATQLVGYVVTQAAPSDPAAlrDTLRQALKASLPEHMVPAHLLFLERLPL 2060
Cdd:cd12114    389 GYRIELGEIEAALQAHPGVARAVVVVLGDPGGKRLAAFVVPDNDGTPIAP--DALRAFLAQTLPAYMIPSRVIALEALPL 466

                          490
                   ....*....|.
gi 2183974163 2061 TANGKLDRRAL 2071
Cdd:cd12114    467 TANGKVDRAAL 477

A_NRPS_ACVS-like

cd17648

N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase; This family contains ACV ...

1582-2072

7.76e-128

N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase; This family contains ACV synthetase (ACVS, EC 6.3.2.26; also known as N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase or delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase) is involved in medically important antibiotic biosynthesis. ACV synthetase is active in an early step in the penicillin G biosynthesis pathway which involves the formation of the tripeptide 6-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine (ACV); each of the constituent amino acids of the tripeptide ACV are activated as aminoacyl-adenylates with peptide bonds formed through the participation of amino acid thioester intermediates. ACV is then cyclized by the action of isopenicillin N synthase.

Pssm-ID: 341303 [Multi-domain] Cd Length: 453 Bit Score: 411.02 E-value: 7.76e-128

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1582 PRATAVVYGERALDYGELNLRANRLAHRLIELGVG-PDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGYM 1660
Cdd:cd17648      1 PDRVAVVYGDKRLTYRELNERANRLAHYLLSVAEIrPDDLVGLVLDKSELMIIAILAVWKAGAAYVPIDPSYPDERIQFI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1661 IEDSGIRLLLTqraarerlplgeglpcllldaehewagypesdpqsavGVDNLAYVIYTSGSTGKPKGTLLPHGNVLRLF 1740
Cdd:cd17648     81 LEDTGARVVIT-------------------------------------NSTDLAYAIYTSGTTGKPKGVLVEHGSVVNLR 123

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1741 DATRHWFGFSA--DDAWSLFHSYAFDFSVWEIFGALLHGGRLVIVPYETSRSPEDFLRLLCRERVTVLNQTPSAFKQLMQ 1818
Cdd:cd17648    124 TSLSERYFGRDngDEAVLFFSNYVFDFFVEQMTLALLNGQKLVVPPDEMRFDPDRFYAYINREKVTYLSGTPSVLQQYDL 203

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1819 VACAgqevpplALRHVVFGGEALEVQALRPWFERFgdrAPRLVNMYGITETTVHVTYRPLSLadlDGGAASPIGEPIPDL 1898
Cdd:cd17648    204 ARLP-------HLKRVDAAGEEFTAPVFEKLRSRF---AGLIINAYGPTETTVTNHKRFFPG---DQRFDKSLGRPVRNT 270

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1899 SWYLLDAGLNPVPRGCIGELYVGGAGLARGYLNRPELSCTRFVADPFST-------TGGRLYRTGDLARYRCDGVVEYVG 1971
Cdd:cd17648    271 KCYVLNDAMKRVPVGAVGELYLGGDGVARGYLNRPELTAERFLPNPFQTeqerargRNARLYKTGDLVRWLPSGELEYLG 350

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1972 RIDHQVKIRGFRIELGEIEARLLAQPGVAEAVVLPHEGPGATQ------LVGYVVTQAAPSDPAALRDtlrqALKASLPE 2045
Cdd:cd17648    351 RNDFQVKIRGQRIEPGEVEAALASYPGVRECAVVAKEDASQAQsriqkyLVGYYLPEPGHVPESDLLS----FLRAKLPR 426

                          490       500
                   ....*....|....*....|....*..
gi 2183974163 2046 HMVPAHLLFLERLPLTANGKLDRRALP 2072
Cdd:cd17648    427 YMVPARLVRLEGIPVTINGKLDVRALP 453

A_NRPS_SidN3_like

cd05918

The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); ...

512-1007

4.01e-126

Pssm-ID: 341242 [Multi-domain] Cd Length: 481 Bit Score: 407.31 E-value: 4.01e-126

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  512 VHRLFEAQAGLTPDAPALLFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLD 591
Cdd:cd05918      1 VHDLIEERARSQPDAPAVCAWDGSLTYAELDRLSSRLAHHLRSLGVGPGVFVPLCFEKSKWAVVAMLAVLKAGGAFVPLD 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  592 PQYPADRLQYMIDDSGLRLLLSqqsvlarlpqsdglqslllddlerlvhgypaenpdlpEAPDSLCYAIYTSGSTGQPKG 671
Cdd:cd05918     81 PSHPLQRLQEILQDTGAKVVLT-------------------------------------SSPSDAAYVIFTSGSTGKPKG 123

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  672 VMVRHRALTNFVCSIARQPGMLARDRLLSVTTFSFDIFGLELYVPLARGASMLLASREQAQDpeALLDLVERQGVTVLQA 751
Cdd:cd05918    124 VVIEHRALSTSALAHGRALGLTSESRVLQFASYTFDVSILEIFTTLAAGGCLCIPSEEDRLN--DLAGFINRLRVTWAFL 201

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  752 TPATWRMLcDSERVDLLRgcTLLCGGEALAEDLAArmrglsasTW-------NLYGPTETTIWSARFRLGEEARP-FLGG 823
Cdd:cd05918    202 TPSVARLL-DPEDVPSLR--TLVLGGEALTQSDVD--------TWadrvrliNAYGPAECTIAATVSPVVPSTDPrNIGR 270

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  824 PLeNTALYILDSE-MN-PCPPGVAGELLIGGDGLARGYHRRPGLTAERFLPDPF------AADGSRLYRTGDLARYRADG 895
Cdd:cd05918    271 PL-GATCWVVDPDnHDrLVPIGAVGELLIEGPILARGYLNDPEKTAAAFIEDPAwlkqegSGRGRRLYRTGDLVRYNPDG 349

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  896 VIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVA----QPGVAGPTLVAYLVPTEAALVDAESARQ------- 964
Cdd:cd05918    350 SLEYVGRKDTQVKIRGQRVELGEIEHHLRQSLPGAKEVVVEvvkpKDGSSSPQLVAFVVLDGSSSGSGDGDSLflepsde 429

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....
gi 2183974163  965 -QELRSALKNSLLAVLPDYMVPAHMLLLENLPLTPNGKINRKAL 1007
Cdd:cd05918    430 fRALVAELRSKLRQRLPSYMVPSVFLPLSHLPLTASGKIDRRAL 473

A_NRPS_ProA

cd17656

gramicidin S synthase 2, also known as ATP-dependent proline adenylase; This family of the ...

1582-2072

4.73e-126

gramicidin S synthase 2, also known as ATP-dependent proline adenylase; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) contains gramicidin S synthase 2 (also known as ATP-dependent proline adenylase or proline activase or ProA). ProA is a multifunctional enzyme involved in synthesis of the cyclic peptide antibiotic gramicidin S and able to activate and polymerize the amino acids proline, valine, ornithine and leucine. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.

Pssm-ID: 341311 [Multi-domain] Cd Length: 479 Bit Score: 406.86 E-value: 4.73e-126

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1582 PRATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGYMI 1661
Cdd:cd17656      2 PDAVAVVFENQKLTYRELNERSNQLARFLREKGVKKDSIVAIMMERSAEMIVGILGILKAGGAFVPIDPEYPEERRIYIM 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1662 EDSGIRLLLTQRAARERLPLGEGLPCLLLDAEHEWAGypeSDPQSAVGVDNLAYVIYTSGSTGKPKGTLLPHGNVLRLFD 1741
Cdd:cd17656     82 LDSGVRVVLTQRHLKSKLSFNKSTILLEDPSISQEDT---SNIDYINNSDDLLYIIYTSGTTGKPKGVQLEHKNMVNLLH 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1742 ATRHWFGFSADDAWSLFHSYAFDFSVWEIFGALLHGGRLVIVPYETSRSPEDFLRLLCRERVTVLNqTPSAFkqLMQVAC 1821
Cdd:cd17656    159 FEREKTNINFSDKVLQFATCSFDVCYQEIFSTLLSGGTLYIIREETKRDVEQLFDLVKRHNIEVVF-LPVAF--LKFIFS 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1822 AGQEVPPLA--LRHVVFGGEALEVQalRPWFERFGDRAPRLVNMYGITETTVHVTYRplsladLDGGAA----SPIGEPI 1895
Cdd:cd17656    236 EREFINRFPtcVKHIITAGEQLVIT--NEFKEMLHEHNVHLHNHYGPSETHVVTTYT------INPEAEipelPPIGKPI 307

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1896 PDLSWYLLDAGLNPVPRGCIGELYVGGAGLARGYLNRPELSCTRFVADPFSTTgGRLYRTGDLARYRCDGVVEYVGRIDH 1975
Cdd:cd17656    308 SNTWIYILDQEQQLQPQGIVGELYISGASVARGYLNRQELTAEKFFPDPFDPN-ERMYRTGDLARYLPDGNIEFLGRADH 386

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1976 QVKIRGFRIELGEIEARLLAQPGVAEAVVLPH-EGPGATQLVGYVVTQAAPSDpaalrDTLRQALKASLPEHMVPAHLLF 2054
Cdd:cd17656    387 QVKIRGYRIELGEIEAQLLNHPGVSEAVVLDKaDDKGEKYLCAYFVMEQELNI-----SQLREYLAKQLPEYMIPSFFVP 461

                          490
                   ....*....|....*...
gi 2183974163 2055 LERLPLTANGKLDRRALP 2072
Cdd:cd17656    462 LDQLPLTPNGKVDRKALP 479

A_NRPS_ProA

cd17656

gramicidin S synthase 2, also known as ATP-dependent proline adenylase; This family of the ...

523-1008

5.13e-124

Pssm-ID: 341311 [Multi-domain] Cd Length: 479 Bit Score: 401.08 E-value: 5.13e-124

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  523 TPDAPALLFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQYM 602
Cdd:cd17656      1 TPDAVAVVFENQKLTYRELNERSNQLARFLREKGVKKDSIVAIMMERSAEMIVGILGILKAGGAFVPIDPEYPEERRIYI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  603 IDDSGLRLLLSQQSvLARLPQSDGLQSLLLDDLERLVHGypaENPDLPEAPDSLCYAIYTSGSTGQPKGVMVRHRALTNF 682
Cdd:cd17656     81 MLDSGVRVVLTQRH-LKSKLSFNKSTILLEDPSISQEDT---SNIDYINNSDDLLYIIYTSGTTGKPKGVQLEHKNMVNL 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  683 VCSIARQPGMLARDRLLSVTTFSFDIFGLELYVPLARGASMLLASREQAQDPEALLDLVERQGVTVLQATPATWRMLCdS 762
Cdd:cd17656    157 LHFEREKTNINFSDKVLQFATCSFDVCYQEIFSTLLSGGTLYIIREETKRDVEQLFDLVKRHNIEVVFLPVAFLKFIF-S 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  763 ER--VDLLRGCT--LLCGGEAL--AEDLAARMRGLSASTWNLYGPTETTIWSArFRLGEEAR----PFLGGPLENTALYI 832
Cdd:cd17656    236 ERefINRFPTCVkhIITAGEQLviTNEFKEMLHEHNVHLHNHYGPSETHVVTT-YTINPEAEipelPPIGKPISNTWIYI 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  833 LDSEMNPCPPGVAGELLIGGDGLARGYHRRPGLTAERFLPDPFAADgSRLYRTGDLARYRADGVIEYLGRIDHQVKIRGF 912
Cdd:cd17656    315 LDQEQQLQPQGIVGELYISGASVARGYLNRQELTAEKFFPDPFDPN-ERMYRTGDLARYLPDGNIEFLGRADHQVKIRGY 393

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  913 RIELGEIETRLLEQDSVREAVVVAQPGVAGPT-LVAYLVPtEAALVDAEsarqqelrsaLKNSLLAVLPDYMVPAHMLLL 991
Cdd:cd17656    394 RIELGEIEAQLLNHPGVSEAVVLDKADDKGEKyLCAYFVM-EQELNISQ----------LREYLAKQLPEYMIPSFFVPL 462

                          490
                   ....*....|....*..
gi 2183974163  992 ENLPLTPNGKINRKALP 1008
Cdd:cd17656    463 DQLPLTPNGKVDRKALP 479

DltA

cd05945

D-alanine:D-alanyl carrier protein ligase (DltA) and similar proteins; This family includes ...

1578-2071

1.38e-122

D-alanine:D-alanyl carrier protein ligase (DltA) and similar proteins; This family includes D-alanyl carrier protein ligase DltA and aliphatic beta-amino acid adenylation enzymes IdnL1 and CmiS6. DltA incorporates D-ala in techoic acids in gram-positive bacteria via a two-step process, starting with adenylation of D-alanine that transfers D-alanine to the D-alanyl carrier protein. IdnL1, a short-chain aliphatic beta-amino acid adenylation enzyme, recognizes 3-aminobutanoic acid, and is involved in the synthesis of the macrolactam antibiotic incednine. CmiS6 is a medium-chain beta-amino acid adenylation enzyme that recognizes 3-aminononanoic acid, and is involved in the synthesis of cremimycin, also a macrolactam antibiotic. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.

Pssm-ID: 341267 [Multi-domain] Cd Length: 449 Bit Score: 395.85 E-value: 1.38e-122

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1578 AAERPRATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRL 1657
Cdd:cd05945      1 AAANPDRPAVVEGGRTLTYRELKERADALAAALASLGLDAGDPVVVYGHKSPDAIAAFLAALKAGHAYVPLDASSPAERI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1658 GYMIEDSGirllltqraarerlplgeglPCLLLDAEHEwagypesdpqsavgvdnLAYVIYTSGSTGKPKGTLLPHGNVL 1737
Cdd:cd05945     81 REILDAAK--------------------PALLIADGDD-----------------NAYIIFTSGSTGRPKGVQISHDNLV 123

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1738 RLFDATRHWFGFSADDAWSLFHSYAFDFSVWEIFGALLHGGRLVIVPYETSRSPEDFLRLLCRERVTVLNQTPSAFKQLM 1817
Cdd:cd05945    124 SFTNWMLSDFPLGPGDVFLNQAPFSFDLSVMDLYPALASGATLVPVPRDATADPKQLFRFLAEHGITVWVSTPSFAAMCL 203

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1818 QVACAGQEVPPlALRHVVFGGEALEVQALRPWFERFGDRapRLVNMYGITETTVHVTYRPLSLADLDGGAASPIGEPIPD 1897
Cdd:cd05945    204 LSPTFTPESLP-SLRHFLFCGEVLPHKTARALQQRFPDA--RIYNTYGPTEATVAVTYIEVTPEVLDGYDRLPIGYAKPG 280

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1898 LSWYLLDAGLNPVPRGCIGELYVGGAGLARGYLNRPELSCTRFVADPfsttGGRLYRTGDLARYRCDGVVEYVGRIDHQV 1977
Cdd:cd05945    281 AKLVILDEDGRPVPPGEKGELVISGPSVSKGYLNNPEKTAAAFFPDE----GQRAYRTGDLVRLEADGLLFYRGRLDFQV 356

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1978 KIRGFRIELGEIEARLLAQPGVAEAVVLP-HEGPGATQLVGYVVTQaaPSDPAALRDTLRQALKASLPEHMVPAHLLFLE 2056
Cdd:cd05945    357 KLNGYRIELEEIEAALRQVPGVKEAVVVPkYKGEKVTELIAFVVPK--PGAEAGLTKAIKAELAERLPPYMIPRRFVYLD 434

                          490
                   ....*....|....*
gi 2183974163 2057 RLPLTANGKLDRRAL 2071
Cdd:cd05945    435 ELPLNANGKIDRKAL 449

LCL_NRPS

LCL-type Condensation domain of non-ribosomal peptide synthetases (NRPSs) and similar domains; ...

1114-1535

3.52e-121

LCL-type Condensation domain of non-ribosomal peptide synthetases (NRPSs) and similar domains; LCL-type Condensation (C) domains catalyze peptide bond formation between two L-amino acids, ((L)C(L)). C-domains of NRPSs catalyze peptide bond formation within (usually) large multi-modular enzymatic complexes. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long (with various activities such as antibiotic, antifungal, antitumor and immunosuppression). In addition to the LCL-type, there are various subtypes of C-domains such as the DCL-type which links an L-amino acid to the D-amino acid at the end of a growing peptide, starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and heterocyclization (Cyc) domains which catalyze both peptide bond formation and cyclization of Cys, Ser, or Thr residues. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the epimerization (E) domain, the ester-bond forming C-domain, dual E/C (epimerization and condensation) domains, and the X-domain. C-domains typically have a conserved HHxxxD motif at the active site; mutations in this motif can abolish or diminish condensation activity. An HHxx[SAG]DGxSx(6)[ED] motif is characteristic of LCL-type C-domains.

Pssm-ID: 380461 [Multi-domain] Cd Length: 432 Bit Score: 390.86 E-value: 3.52e-121

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1114 LSFAQERQWFIWRLDPHSAAYNIPVALRLKGPLRRDALQGALDLLVQRHETLRTTFVEHDGAPRQVIhptlpIAIEERRP 1193
Cdd:cd19538      4 LSFAQRRLWFLHQLEGPSATYNIPLVIKLKGKLDVQALQQALYDVVERHESLRTVFPEEDGVPYQLI-----LEEDEATP 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1194 P-----VAGEDLKGLVETEAHRPFDLQRGPLLRVLLLPLATDECVLVLTLHHIIADGWSMQVLVDELIRVYAALRHDQPP 1268
Cdd:cd19538     79 KleikeVDEEELESEINEAVRYPFDLSEEPPFRATLFELGENEHVLLLLLHHIAADGWSLAPLTRDLSKAYRARCKGEAP 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1269 ALAELPIQYADFAAWQRQWMDGGER-----ERQLDYWVSRLGGEQPLLELPSDRPRPQQQSHRGRRIGIPLPAELAEALR 1343
Cdd:cd19538    159 ELAPLPVQYADYALWQQELLGDESDpdsliARQLAYWKKQLAGLPDEIELPTDYPRPAESSYEGGTLTFEIDSELHQQLL 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1344 RLAQAEQGTLFMLLLASFQALLHRYSGQNDIRVGVPIANRNREETEGLIGFFVNTQVLRAELDGQLPFRELLRQVRQAVV 1423
Cdd:cd19538    239 QLAKDNNVTLFMVLQAGFAALLTRLGAGTDIPIGSPVAGRNDDSLEDLVGFFVNTLVLRTDTSGNPSFRELLERVKETNL 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1424 EAQGHQDLPFEQLVDALQPERSLSHAPLFQVMYNHQrddhrGSRFASlgeLEVEDLAWDVQ-----TAQFDLTLD----- 1493
Cdd:cd19538    319 EAYEHQDIPFERLVEALNPTRSRSRHPLFQIMLALQ-----NTPQPS---LDLPGLEAKLElrtvgSAKFDLTFElreqy 390

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|..
gi 2183974163 1494 TYESSNGLLAELTYATDLFDASSAERIAGHWLNLLRSIVARP 1535
Cdd:cd19538    391 NDGTPNGIEGFIEYRTDLFDHETIEALAQRYLLLLESAVENP 432

A_NRPS_GliP_like

cd17653

nonribosomal peptide synthase GliP-like; This family includes the adenylation (A) domain of ...

1572-2071

4.71e-121

nonribosomal peptide synthase GliP-like; This family includes the adenylation (A) domain of nonribosomal peptide synthases (NRPS) gliotoxin biosynthesis protein P (GliP), thioclapurine biosynthesis protein P (tcpP) and Sirodesmin biosynthesis protein P (SirP). In the filamentous fungus Aspergillus fumigatus, NRPS GliP is involved in the biosynthesis of gliotoxin, which is initiated by the condensation of serine and phenylalanine. Studies show that GliP is not required for invasive aspergillosis, suggesting that the principal targets of gliotoxin are neutrophils or other phagocytes. SirP is a phytotoxin produced by the fungus Leptosphaeria maculans, which causes blackleg disease of canola (Brassica napus). In the fungus Claviceps purpurea, NRPS tcpP catalyzes condensation of tyrosine and glycine, part of biosynthesis of an unusual class of epipolythiodioxopiperazines (ETPs) that lacks the reactive thiol group for toxicity. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.

Pssm-ID: 341308 [Multi-domain] Cd Length: 433 Bit Score: 390.52 E-value: 4.71e-121

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1572 RLIERQAAERPRATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPR 1651
Cdd:cd17653      1 DAFERIAAAHPDAVAVESLGGSLTYGELDAASNALANRLLQLGVVPGDVVPLLSDRSLEMLVAILAILKAGAAYVPLDAK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1652 YPSDRLGYMIEDSGIRLLLTQRAArerlplgeglpcllldaehewagypesdpqsavgvDNLAYVIYTSGSTGKPKGTLL 1731
Cdd:cd17653     81 LPSARIQAILRTSGATLLLTTDSP-----------------------------------DDLAYIIFTSGSTGIPKGVMV 125

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1732 PHGNVLRLFDATRHWFGFSADDAWSLFHSYAFDFSVWEIFGALLHGGRLVIvpyetsRSPEDFLRLLCRErVTVLNQTPS 1811
Cdd:cd17653    126 PHRGVLNYVSQPPARLDVGPGSRVAQVLSIAFDACIGEIFSTLCNGGTLVL------ADPSDPFAHVART-VDALMSTPS 198

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1812 AFkqlmqVACAGQEVPplALRHVVFGGEALEVQALRPWFERfgdraPRLVNMYGITETTVHVTYRPLSLadldgGAASPI 1891
Cdd:cd17653    199 IL-----STLSPQDFP--NLKTIFLGGEAVPPSLLDRWSPG-----RRLYNAYGPTECTISSTMTELLP-----GQPVTI 261

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1892 GEPIPDLSWYLLDAGLNPVPRGCIGELYVGGAGLARGYLNRPELSCTRFVADPFStTGGRLYRTGDLARYRCDGVVEYVG 1971
Cdd:cd17653    262 GKPIPNSTCYILDADLQPVPEGVVGEICISGVQVARGYLGNPALTASKFVPDPFW-PGSRMYRTGDYGRWTEDGGLEFLG 340

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1972 RIDHQVKIRGFRIELGEIEARLLA-QPGVAEAVVLPHEGpgatQLVGYVVTQAApsDPAALRDTLRQalkaSLPEHMVPA 2050
Cdd:cd17653    341 REDNQVKVRGFRINLEEIEEVVLQsQPEVTQAAAIVVNG----RLVAFVTPETV--DVDGLRSELAK----HLPSYAVPD 410

                          490       500
                   ....*....|....*....|.
gi 2183974163 2051 HLLFLERLPLTANGKLDRRAL 2071
Cdd:cd17653    411 RIIALDSFPLTANGKVDRKAL 431

A_NRPS_LgrA-like

cd17645

adenylation (A) domain of linear gramicidin synthetase (LgrA) and similar proteins; This ...

513-1008

1.03e-120

adenylation (A) domain of linear gramicidin synthetase (LgrA) and similar proteins; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes linear gramicidin synthetase (LgrA) in Brevibacillus brevis. LgrA has a formylation domain fused to the N-terminal end that formylates its substrate for linear gramicidin synthesis to proceed. This formyl group is essential for the clinically important antibacterial activity of gramicidin by enabling head-to-head gramicidin dimers to make a beta-helical pore in gram-positive bacterial membranes, allowing free passage of monovalent cations, destroying the ion gradient and killing bacteria. This family also includes bacitracin synthetase 1 (known as ATP-dependent cysteine adenylase or BA1); it activates cysteine, incorporates two D-amino acids, releases and cyclizes the mature bacitracin, an antibiotic that is a mixture of related cyclic peptides that disrupt gram positive bacteria by interfering with cell wall and peptidoglycan synthesis. Also included is surfactin synthetase which activates and polymerizes the amino acids Leu, Glu, Asp, and Val to form the antibiotic surfactin.

Pssm-ID: 341300 [Multi-domain] Cd Length: 440 Bit Score: 389.99 E-value: 1.03e-120

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  513 HRLFEAQAGLTPDAPALLFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDP 592
Cdd:cd17645      1 HQLFEEQVERTPDHVAVVDRGQSLTYKQLNEKANQLARHLRGKGVKPDDQVGIMLDKSLDMIAAILGVLKAGGAYVPIDP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  593 QYPADRLQYMIDDSGLRLLLSQqsvlarlpqsdglqslllddlerlvhgypaenpdlpeaPDSLCYAIYTSGSTGQPKGV 672
Cdd:cd17645     81 DYPGERIAYMLADSSAKILLTN--------------------------------------PDDLAYVIYTSGSTGLPKGV 122

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  673 MVRHRALTNFvCSIARQP-GMLARDRLLSVTTFSFDIFGLELYVPLARGASMLLASREQAQDPEALLDLVERQGVTV--L 749
Cdd:cd17645    123 MIEHHNLVNL-CEWHRPYfGVTPADKSLVYASFSFDASAWEIFPHLTAGAALHVVPSERRLDLDALNDYFNQEGITIsfL 201

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  750 QATPATWRMLCDSERvdlLRgcTLLCGGEALAedlaaRMRGLSASTWNLYGPTETTIWSARFRLG-EEARPFLGGPLENT 828
Cdd:cd17645    202 PTGAAEQFMQLDNQS---LR--VLLTGGDKLK-----KIERKGYKLVNNYGPTENTVVATSFEIDkPYANIPIGKPIDNT 271

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  829 ALYILDSEMNPCPPGVAGELLIGGDGLARGYHRRPGLTAERFLPDPFAAdGSRLYRTGDLARYRADGVIEYLGRIDHQVK 908
Cdd:cd17645    272 RVYILDEALQLQPIGVAGELCIAGEGLARGYLNRPELTAEKFIVHPFVP-GERMYRTGDLAKFLPDGNIEFLGRLDQQVK 350

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  909 IRGFRIELGEIETRLLEQDSVREAVVVAQPGVAG-PTLVAYLVPteaalvdAESARQQELRSALKNSllavLPDYMVPAH 987
Cdd:cd17645    351 IRGYRIEPGEIEPFLMNHPLIELAAVLAKEDADGrKYLVAYVTA-------PEEIPHEELREWLKND----LPDYMIPTY 419

                          490       500
                   ....*....|....*....|.
gi 2183974163  988 MLLLENLPLTPNGKINRKALP 1008
Cdd:cd17645    420 FVHLKALPLTANGKVDRKALP 440

A_NRPS_LgrA-like

cd17645

adenylation (A) domain of linear gramicidin synthetase (LgrA) and similar proteins; This ...

1571-2072

2.95e-120

Pssm-ID: 341300 [Multi-domain] Cd Length: 440 Bit Score: 388.84 E-value: 2.95e-120

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1571 HRLIERQAAERPRATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDP 1650
Cdd:cd17645      1 HQLFEEQVERTPDHVAVVDRGQSLTYKQLNEKANQLARHLRGKGVKPDDQVGIMLDKSLDMIAAILGVLKAGGAYVPIDP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1651 RYPSDRLGYMIEDSGIRLLLTQraarerlplgeglpcllldaehewagypesdpqsavgVDNLAYVIYTSGSTGKPKGTL 1730
Cdd:cd17645     81 DYPGERIAYMLADSSAKILLTN-------------------------------------PDDLAYVIYTSGSTGLPKGVM 123

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1731 LPHGNVLRLFDATRHWFGFSADDAWSLFHSYAFDFSVWEIFGALLHGGRLVIVPYETSRSPEDFLRLLCRERVTVLNQTP 1810
Cdd:cd17645    124 IEHHNLVNLCEWHRPYFGVTPADKSLVYASFSFDASAWEIFPHLTAGAALHVVPSERRLDLDALNDYFNQEGITISFLPT 203

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1811 SAFKQLMQVACAgqevpplALRHVVFGGEALEVQALRPWferfgdrapRLVNMYGITETTVHVTyrplsLADLDGGAAS- 1889
Cdd:cd17645    204 GAAEQFMQLDNQ-------SLRVLLTGGDKLKKIERKGY---------KLVNNYGPTENTVVAT-----SFEIDKPYANi 262

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1890 PIGEPIPDLSWYLLDAGLNPVPRGCIGELYVGGAGLARGYLNRPELSCTRFVADPFsTTGGRLYRTGDLARYRCDGVVEY 1969
Cdd:cd17645    263 PIGKPIDNTRVYILDEALQLQPIGVAGELCIAGEGLARGYLNRPELTAEKFIVHPF-VPGERMYRTGDLAKFLPDGNIEF 341

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1970 VGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVVLPHE-GPGATQLVGYVVTQaAPSDPAALRDTlrqaLKASLPEHMV 2048
Cdd:cd17645    342 LGRLDQQVKIRGYRIEPGEIEPFLMNHPLIELAAVLAKEdADGRKYLVAYVTAP-EEIPHEELREW----LKNDLPDYMI 416

                          490       500
                   ....*....|....*....|....
gi 2183974163 2049 PAHLLFLERLPLTANGKLDRRALP 2072
Cdd:cd17645    417 PTYFVHLKALPLTANGKVDRKALP 440

LCL_NRPS

LCL-type Condensation domain of non-ribosomal peptide synthetases (NRPSs) and similar domains; ...

47-477

3.48e-120

Pssm-ID: 380461 [Multi-domain] Cd Length: 432 Bit Score: 388.16 E-value: 3.48e-120

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163   47 RIPLSYAQERQWFLWQMDPQSAAYNIPSALRLRGELDVEALSASLGAIVERHQSLRTVFVEDeqlDGFRQQVLASVDVPV 126
Cdd:cd19538      1 EIPLSFAQRRLWFLHQLEGPSATYNIPLVIKLKGKLDVQALQQALYDVVERHESLRTVFPEE---DGVPYQLILEEDEAT 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  127 PVTLAGDDDaQAQIRAFVESETQQPFDLRNGPLLRARLLRLAADDHVLTLTIHHVAADGWSMRVLVEELIALYGARRQGI 206
Cdd:cd19538     78 PKLEIKEVD-EEELESEINEAVRYPFDLSEEPPFRATLFELGENEHVLLLLLHHIAADGWSLAPLTRDLSKAYRARCKGE 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  207 EATLPDLPIQYADYAIWQRHWLEAGER-----ERQLEYWMARLGGGQSVLELPTDRQRPALPSYRGARHELQLPQALGRQ 281
Cdd:cd19538    157 APELAPLPVQYADYALWQQELLGDESDpdsliARQLAYWKKQLAGLPDEIELPTDYPRPAESSYEGGTLTFEIDSELHQQ 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  282 LQALAQREGTTLFMLLLASFQALLHRYSGQDEIRVGVPVANRNRVETERLIGFFVNTQVLRADLDAQMPFLDLLQQTRVA 361
Cdd:cd19538    237 LLQLAKDNNVTLFMVLQAGFAALLTRLGAGTDIPIGSPVAGRNDDSLEDLVGFFVNTLVLRTDTSGNPSFRELLERVKET 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  362 ALGAQSHQDLPFEQLVEALQPERSLSHSPLFQAMYNHQNlgsagrqslaAQLPGLSVEDLSWGAH-----SAQFDLTLD- 435
Cdd:cd19538    317 NLEAYEHQDIPFERLVEALNPTRSRSRHPLFQIMLALQN----------TPQPSLDLPGLEAKLElrtvgSAKFDLTFEl 386

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*.
gi 2183974163  436 ----TYESEQGVHAEFTYATDLFEAATVERLARHWRNLLEAVVAEP 477
Cdd:cd19538    387 reqyNDGTPNGIEGFIEYRTDLFDHETIEALAQRYLLLLESAVENP 432

A_NRPS_ACVS-like

cd17648

N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase; This family contains ACV ...

524-1008

1.03e-119

Pssm-ID: 341303 [Multi-domain] Cd Length: 453 Bit Score: 387.53 E-value: 1.03e-119

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  524 PDAPALLFGEERLSYAELNALANRLAWRLREEGVG-SDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQYM 602
Cdd:cd17648      1 PDRVAVVYGDKRLTYRELNERANRLAHYLLSVAEIrPDDLVGLVLDKSELMIIAILAVWKAGAAYVPIDPSYPDERIQFI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  603 IDDSGLRLLLSQQSVLArlpqsdglqslllddlerlvhgypaenpdlpeapdslcYAIYTSGSTGQPKGVMVRHRALTNF 682
Cdd:cd17648     81 LEDTGARVVITNSTDLA--------------------------------------YAIYTSGTTGKPKGVLVEHGSVVNL 122

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  683 VCSIARQPGMLARD--RLLSVTTFSFDIFGLELYVPLARGASMLLASREQAQDPEALLDLVERQGVTVLQATPATWRMLc 760
Cdd:cd17648    123 RTSLSERYFGRDNGdeAVLFFSNYVFDFFVEQMTLALLNGQKLVVPPDEMRFDPDRFYAYINREKVTYLSGTPSVLQQY- 201

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  761 DSERVDLLRgcTLLCGGEALAEDLAARMRG-LSASTWNLYGPTETTIWS--ARFRLGEEARPFLGGPLENTALYILDSEM 837
Cdd:cd17648    202 DLARLPHLK--RVDAAGEEFTAPVFEKLRSrFAGLIINAYGPTETTVTNhkRFFPGDQRFDKSLGRPVRNTKCYVLNDAM 279

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  838 NPCPPGVAGELLIGGDGLARGYHRRPGLTAERFLPDPFAADG-------SRLYRTGDLARYRADGVIEYLGRIDHQVKIR 910
Cdd:cd17648    280 KRVPVGAVGELYLGGDGVARGYLNRPELTAERFLPNPFQTEQerargrnARLYKTGDLVRWLPSGELEYLGRNDFQVKIR 359

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  911 GFRIELGEIETRLLEQDSVREAVVVAQPGVAGPT------LVAYLVPteaalvDAESARQQELRSALKnsllAVLPDYMV 984
Cdd:cd17648    360 GQRIEPGEVEAALASYPGVRECAVVAKEDASQAQsriqkyLVGYYLP------EPGHVPESDLLSFLR----AKLPRYMV 429

                          490       500
                   ....*....|....*....|....
gi 2183974163  985 PAHMLLLENLPLTPNGKINRKALP 1008
Cdd:cd17648    430 PARLVRLEGIPVTINGKLDVRALP 453

AMP-binding

AMP-binding enzyme;

1574-1980

1.80e-116

AMP-binding enzyme;

Pssm-ID: 459834 [Multi-domain] Cd Length: 417 Bit Score: 376.65 E-value: 1.80e-116

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1574 IERQAAERPRATAVVYGE-RALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRY 1652
Cdd:pfam00501    1 LERQAARTPDKTALEVGEgRRLTYRELDERANRLAAGLRALGVGKGDRVAILLPNSPEWVVAFLACLKAGAVYVPLNPRL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1653 PSDRLGYMIEDSGIRLLLTQ--------RAARERLPLG------EGLPCLLLDAEHEWAGYPESDPQSAVGV--DNLAYV 1716
Cdd:pfam00501   81 PAEELAYILEDSGAKVLITDdalkleelLEALGKLEVVklvlvlDRDPVLKEEPLPEEAKPADVPPPPPPPPdpDDLAYI 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1717 IYTSGSTGKPKGTLLPHGNVLR----LFDATRHWFGFSADDAWSLFHSYAFDFSV-WEIFGALLHGGRLVIVPYETSRSP 1791
Cdd:pfam00501  161 IYTSGTTGKPKGVMLTHRNLVAnvlsIKRVRPRGFGLGPDDRVLSTLPLFHDFGLsLGLLGPLLAGATVVLPPGFPALDP 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1792 EDFLRLLCRERVTVLNQTPSAFKQLMQVACAGQEVPPlALRHVVFGGEALEVQALRPWFERFGdraPRLVNMYGITETTV 1871
Cdd:pfam00501  241 AALLELIERYKVTVLYGVPTLLNMLLEAGAPKRALLS-SLRLVLSGGAPLPPELARRFRELFG---GALVNGYGLTETTG 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1872 HVTYRPlsLADLDGGAASPIGEPIPDLSWYLLD-AGLNPVPRGCIGELYVGGAGLARGYLNRPELSCTRFVADpfsttgg 1950
Cdd:pfam00501  317 VVTTPL--PLDEDLRSLGSVGRPLPGTEVKIVDdETGEPVPPGEPGELCVRGPGVMKGYLNDPELTAEAFDED------- 387

                          410       420       430
                   ....*....|....*....|....*....|
gi 2183974163 1951 RLYRTGDLARYRCDGVVEYVGRIDHQVKIR 1980
Cdd:pfam00501  388 GWYRTGDLGRRDEDGYLEIVGRKKDQIKLG 417

MenE/FadK

COG0318

O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) [Lipid ...

1570-2073

3.91e-115

O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism]; O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) is part of the Pathway/BioSystem: Menaquinone biosynthesis

Pssm-ID: 440087 [Multi-domain] Cd Length: 452 Bit Score: 374.53 E-value: 3.91e-115

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1570 LHRLIERQAAERPRATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLD 1649
Cdd:COG0318      1 LADLLRRAAARHPDRPALVFGGRRLTYAELDARARRLAAALRALGVGPGDRVALLLPNSPEFVVAFLAALRAGAVVVPLN 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1650 PRYPSDRLGYMIEDSGIRLLLTqraarerlplgeglpcllldaehewagypesdpqsavgvdnlAYVIYTSGSTGKPKGT 1729
Cdd:COG0318     81 PRLTAEELAYILEDSGARALVT------------------------------------------ALILYTSGTTGRPKGV 118

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1730 LLPHGNVLRLFDATRHWFGFSADDAW----SLFHSYAFdfsVWEIFGALLHGGRLVIVPyetSRSPEDFLRLLCRERVTV 1805
Cdd:COG0318    119 MLTHRNLLANAAAIAAALGLTPGDVVlvalPLFHVFGL---TVGLLAPLLAGATLVLLP---RFDPERVLELIERERVTV 192

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1806 LNQTPSAFKQLMQVACAGQEVPPlALRHVVFGGEALEVQALRPWFERFGdraPRLVNMYGITETTVHVTYRPlslADLDG 1885
Cdd:COG0318    193 LFGVPTMLARLLRHPEFARYDLS-SLRLVVSGGAPLPPELLERFEERFG---VRIVEGYGLTETSPVVTVNP---EDPGE 265

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1886 GAASPIGEPIPDLSWYLLDAGLNPVPRGCIGELYVGGAGLARGYLNRPELSCTRFvADPFsttggrlYRTGDLARYRCDG 1965
Cdd:COG0318    266 RRPGSVGRPLPGVEVRIVDEDGRELPPGEVGEIVVRGPNVMKGYWNDPEATAEAF-RDGW-------LRTGDLGRLDEDG 337

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1966 VVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVV--LPHEGPGATQLVGYVVTQAAPSDPAALRDTLRQAlkasL 2043
Cdd:COG0318    338 YLYIVGRKKDMIISGGENVYPAEVEEVLAAHPGVAEAAVvgVPDEKWGERVVAFVVLRPGAELDAEELRAFLRER----L 413

                          490       500       510
                   ....*....|....*....|....*....|
gi 2183974163 2044 PEHMVPAHLLFLERLPLTANGKLDRRALPA 2073
Cdd:COG0318    414 ARYKVPRRVEFVDELPRTASGKIDRRALRE 443

A_NRPS_GliP_like

cd17653

nonribosomal peptide synthase GliP-like; This family includes the adenylation (A) domain of ...

514-1007

6.06e-114

Pssm-ID: 341308 [Multi-domain] Cd Length: 433 Bit Score: 370.10 E-value: 6.06e-114

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  514 RLFEAQAGLTPDAPALLFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQ 593
Cdd:cd17653      1 DAFERIAAAHPDAVAVESLGGSLTYGELDAASNALANRLLQLGVVPGDVVPLLSDRSLEMLVAILAILKAGAAYVPLDAK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  594 YPADRLQYMIDDSGLRLLLSqqsvlarlpqsdglqslllddlerlvhgypaenpdlPEAPDSLCYAIYTSGSTGQPKGVM 673
Cdd:cd17653     81 LPSARIQAILRTSGATLLLT------------------------------------TDSPDDLAYIIFTSGSTGIPKGVM 124

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  674 VRHRALTNFVC-SIAR---QPGmlarDRLLSVTTFSFDIFGLELYVPLARGASMLLAsreqaqDPEALLDLVERQgVTVL 749
Cdd:cd17653    125 VPHRGVLNYVSqPPARldvGPG----SRVAQVLSIAFDACIGEIFSTLCNGGTLVLA------DPSDPFAHVART-VDAL 193

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  750 QATPATWRMLcDSERVDLLRGCTLlcGGEALAEDLAARMRGlSASTWNLYGPTETTIWSARFRLGEEARPFLGGPLENTA 829
Cdd:cd17653    194 MSTPSILSTL-SPQDFPNLKTIFL--GGEAVPPSLLDRWSP-GRRLYNAYGPTECTISSTMTELLPGQPVTIGKPIPNST 269

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  830 LYILDSEMNPCPPGVAGELLIGGDGLARGYHRRPGLTAERFLPDPFaADGSRLYRTGDLARYRADGVIEYLGRIDHQVKI 909
Cdd:cd17653    270 CYILDADLQPVPEGVVGEICISGVQVARGYLGNPALTASKFVPDPF-WPGSRMYRTGDYGRWTEDGGLEFLGREDNQVKV 348

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  910 RGFRIELGEIE-TRLLEQDSVREAVVVaqpgVAGPTLVAYLVPteaalvdaESARQQELRSALKNSllavLPDYMVPAHM 988
Cdd:cd17653    349 RGFRINLEEIEeVVLQSQPEVTQAAAI----VVNGRLVAFVTP--------ETVDVDGLRSELAKH----LPSYAVPDRI 412

                          490
                   ....*....|....*....
gi 2183974163  989 LLLENLPLTPNGKINRKAL 1007
Cdd:cd17653    413 IALDSFPLTANGKVDRKAL 431

AMP-binding

AMP-binding enzyme;

516-910

1.28e-110

AMP-binding enzyme;

Pssm-ID: 459834 [Multi-domain] Cd Length: 417 Bit Score: 360.09 E-value: 1.28e-110

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  516 FEAQAGLTPDAPALLFGE-ERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQY 594
Cdd:pfam00501    1 LERQAARTPDKTALEVGEgRRLTYRELDERANRLAAGLRALGVGKGDRVAILLPNSPEWVVAFLACLKAGAVYVPLNPRL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  595 PADRLQYMIDDSGLRLLLSQQSVLA-----------------RLPQSDGLQSLLLDDLERLVHGYPAENPdlPEAPDSLC 657
Cdd:pfam00501   81 PAEELAYILEDSGAKVLITDDALKLeellealgklevvklvlVLDRDPVLKEEPLPEEAKPADVPPPPPP--PPDPDDLA 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  658 YAIYTSGSTGQPKGVMVRHRALTNFVCSIARQP----GMLARDRLLSVTTFSFDI-FGLELYVPLARGASMLLASREQAQ 732
Cdd:pfam00501  159 YIIYTSGTTGKPKGVMLTHRNLVANVLSIKRVRprgfGLGPDDRVLSTLPLFHDFgLSLGLLGPLLAGATVVLPPGFPAL 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  733 DPEALLDLVERQGVTVLQATPATWRMLCDSERVDL-----LRgcTLLCGGEALAEDLAARMRGLSAST-WNLYGPTETTI 806
Cdd:pfam00501  239 DPAALLELIERYKVTVLYGVPTLLNMLLEAGAPKRallssLR--LVLSGGAPLPPELARRFRELFGGAlVNGYGLTETTG 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  807 WSARFRLGEEARPFL---GGPLENTALYILD-SEMNPCPPGVAGELLIGGDGLARGYHRRPGLTAERFLPDpfaadgsRL 882
Cdd:pfam00501  317 VVTTPLPLDEDLRSLgsvGRPLPGTEVKIVDdETGEPVPPGEPGELCVRGPGVMKGYLNDPELTAEAFDED-------GW 389

                          410       420
                   ....*....|....*....|....*...
gi 2183974163  883 YRTGDLARYRADGVIEYLGRIDHQVKIR 910
Cdd:pfam00501  390 YRTGDLGRRDEDGYLEIVGRKKDQIKLG 417

Condensation

Condensation domain; This domain is found in many multi-domain enzymes which synthesize ...

48-496

2.94e-110

Condensation domain; This domain is found in many multi-domain enzymes which synthesize peptide antibiotics. This domain catalyzes a condensation reaction to form peptide bonds in non- ribosomal peptide biosynthesis. It is usually found to the carboxy side of a phosphopantetheine binding domain (pfam00550). It has been shown that mutations in the HHXXXDG motif abolish activity suggesting this is part of the active site.

Pssm-ID: 395541 [Multi-domain] Cd Length: 454 Bit Score: 360.50 E-value: 2.94e-110

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163   48 IPLSYAQERQWFLWQMDPQSAAYNIPSALRLRGELDVEALSASLGAIVERHQSLRTVFVEDEQLDgFRQQVLASVDVPVP 127
Cdd:pfam00668    5 YPLSPAQKRMWFLEKLEPHSSAYNMPAVLKLTGELDPERLEKALQELINRHDALRTVFIRQENGE-PVQVILEERPFELE 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  128 VTLAGDDDAQAQ---IRAFVESETQQPFDLRNGPLLRARLLRLAADDHVLTLTIHHVAADGWSMRVLVEELIALYGARRQ 204
Cdd:pfam00668   84 IIDISDLSESEEeeaIEAFIQRDLQSPFDLEKGPLFRAGLFRIAENRHHLLLSMHHIIVDGVSLGILLRDLADLYQQLLK 163

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  205 GieATLPDLPIQ-YADYAIWQRHWLEAGERERQLEYWMARLGGGQSVLELPTDRQRPALPSYRGARHELQLPQALGRQLQ 283
Cdd:pfam00668  164 G--EPLPLPPKTpYKDYAEWLQQYLQSEDYQKDAAYWLEQLEGELPVLQLPKDYARPADRSFKGDRLSFTLDEDTEELLR 241

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  284 ALAQREGTTLFMLLLASFQALLHRYSGQDEIRVGVPVANRNRVETERLIGFFVNTQVLRADLDAQMPFLDLLQQTRVAAL 363
Cdd:pfam00668  242 KLAKAHGTTLNDVLLAAYGLLLSRYTGQDDIVVGTPGSGRPSPDIERMVGMFVNTLPLRIDPKGGKTFSELIKRVQEDLL 321

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  364 GAQSHQDLPFEQLVEALQPERSLSHSPLFQAMYNHQNLGSAGRQSLAAQLPGLSVEDLSWGAHSAQFDLTLDTYESEQGV 443
Cdd:pfam00668  322 SAEPHQGYPFGDLVNDLRLPRDLSRHPLFDPMFSFQNYLGQDSQEEEFQLSELDLSVSSVIEEEAKYDLSLTASERGGGL 401

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2183974163  444 HAEFTYATDLFEAATVERLARHWRNLLEAVVAEPRRRLGDLPLLDAEERATLL 496
Cdd:pfam00668  402 TIKIDYNTSLFDEETIERFAEHFKELLEQAIAHPSQPLSELDLLSDAEKQKLL 454

EntF

EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites ...

2619-3183

1.45e-108

EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism];

Pssm-ID: 440643 [Multi-domain] Cd Length: 1329 Bit Score: 381.13 E-value: 1.45e-108

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2619 LDQRQLDALPLAAGEVEDLYPLSPMQQGMLFHSLYQQNSGDYINQMRLDVEGLDPQRFREAWQAALDAHEVLRSGFLWQG 2698
Cdd:COG1020      1 AAAAAAAALPPAAAAAPLPLSAAQQRLWLLLLLLLGSAAYNLALALLLLGLLLVAALLLLAALLARRRRALRTRLRTRAG 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2699 ALEKPLQLVRkRVEVPFSVHDWRDRADLAEALDALAAGEAGLGFELAEAPLLRLVLVRTGERRHHLIYTNHHILMDGWSN 2778
Cdd:COG1020     81 RPVQVIQPVV-AAPLPVVVLLVDLEALAEAAAEAAAAAEALAPFDLLRGPLLRLLLLLLLLLLLLLLLALHHIISDGLSD 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2779 SQLLGEVLQRY----------RGETPSRSDGRYRDYIAWLQRQDAGRTEAFWKQRLQRLGEPTLLVPAFAHGVRGAEGHA 2848
Cdd:COG1020    160 GLLLAELLRLYlaayagaplpLPPLPIQYADYALWQREWLQGEELARQLAYWRQQLAGLPPLLELPTDRPRPAVQSYRGA 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2849 DRYRQLDVTTSQRLAEFAREQKVTLNTLVQAAWLILLQRFTGQDTVAFGATVSGRPAElrGIEEQIGLFINTLPVVASPC 2928
Cdd:COG1020    240 RVSFRLPAELTAALRALARRHGVTLFMVLLAAFALLLARYSGQDDVVVGTPVAGRPRP--ELEGLVGFFVNTLPLRVDLS 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2929 PEQPIGDWLQAVQGENLALREFEHTPLYDIQRWAGQVGEA----LFDNILVFENYPVSA-ALAEETPADMRIDalsnQEQ 3003
Cdd:COG1020    318 GDPSFAELLARVRETLLAAYAHQDLPFERLVEELQPERDLsrnpLFQVMFVLQNAPADElELPGLTLEPLELD----SGT 393

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3004 THYPLTLLVS-AGETLELHYSYSRQAFDEAAIECLAERLERLLLGMCENPGASLGELDSLAVAERYQLLEGWNATAAEYP 3082
Cdd:COG1020    394 AKFDLTLTVVeTGDGLRLTLEYNTDLFDAATIERMAGHLVTLLEALAADPDQPLGDLPLLTAAERQQLLAEWNATAAPYP 473

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3083 LQRGVHRLFEEQVERTPTAPALAFGEERLDYAELNRRANRLAHALIERGIGADRLVGVAMERSIEMVVALMAILKAGGAY 3162
Cdd:COG1020    474 ADATLHELFEAQAARTPDAVAVVFGDQSLTYAELNARANRLAHHLRALGVGPGDLVGVCLERSLEMVVALLAVLKAGAAY 553

                          570       580
                   ....*....|....*....|.
gi 2183974163 3163 VPVDPEYPEERQAYMLEDSGV 3183
Cdd:COG1020    554 VPLDPAYPAERLAYMLEDAGA 574

Condensation

Condensation domain; This domain is found in many multi-domain enzymes which synthesize ...

1114-1555

1.49e-108

Pssm-ID: 395541 [Multi-domain] Cd Length: 454 Bit Score: 355.49 E-value: 1.49e-108

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1114 LSFAQERQWFIWRLDPHSAAYNIPVALRLKGPLRRDALQGALDLLVQRHETLRTTFVEH-DGAPRQVIHPTLPIAIEErr 1192
Cdd:pfam00668    7 LSPAQKRMWFLEKLEPHSSAYNMPAVLKLTGELDPERLEKALQELINRHDALRTVFIRQeNGEPVQVILEERPFELEI-- 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1193 ppvagEDLKGLVETEAHR------------PFDLQRGPLLRVLLLPLATDECVLVLTLHHIIADGWSMQVLVDELIRVYA 1260
Cdd:pfam00668   85 -----IDISDLSESEEEEaieafiqrdlqsPFDLEKGPLFRAGLFRIAENRHHLLLSMHHIIVDGVSLGILLRDLADLYQ 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1261 ALRHDQPPALAELPiQYADFAAWQRQWMDGGERERQLDYWVSRLGGEQPLLELPSDRPRPQQQSHRGRRIGIPLPAELAE 1340
Cdd:pfam00668  160 QLLKGEPLPLPPKT-PYKDYAEWLQQYLQSEDYQKDAAYWLEQLEGELPVLQLPKDYARPADRSFKGDRLSFTLDEDTEE 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1341 ALRRLAQAEQGTLFMLLLASFQALLHRYSGQNDIRVGVPIANRNREETEGLIGFFVNTQVLRAELDGQLPFRELLRQVRQ 1420
Cdd:pfam00668  239 LLRKLAKAHGTTLNDVLLAAYGLLLSRYTGQDDIVVGTPGSGRPSPDIERMVGMFVNTLPLRIDPKGGKTFSELIKRVQE 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1421 AVVEAQGHQDLPFEQLVDALQPERSLSHAPLFQVMYNHQRDDHRGSrFASLGELEVEDLAWDV---QTAQFDLTLDTYES 1497
Cdd:pfam00668  319 DLLSAEPHQGYPFGDLVNDLRLPRDLSRHPLFDPMFSFQNYLGQDS-QEEEFQLSELDLSVSSvieEEAKYDLSLTASER 397

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2183974163 1498 SNGLLAELTYATDLFDASSAERIAGHWLNLLRSIVARPEARIAELKLLDEAEaRADLL 1555
Cdd:pfam00668  398 GGGLTIKIDYNTSLFDEETIERFAEHFKELLEQAIAHPSQPLSELDLLSDAE-KQKLL 454

DltA

cd05945

D-alanine:D-alanyl carrier protein ligase (DltA) and similar proteins; This family includes ...

523-1007

1.65e-108

Pssm-ID: 341267 [Multi-domain] Cd Length: 449 Bit Score: 355.02 E-value: 1.65e-108

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  523 TPDAPALLFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQYM 602
Cdd:cd05945      4 NPDRPAVVEGGRTLTYRELKERADALAAALASLGLDAGDPVVVYGHKSPDAIAAFLAALKAGHAYVPLDASSPAERIREI 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  603 IDDSGLRLLLSqqsvlarlpqsdglqslllddlerlvhgypaenpdlpeAPDSLCYAIYTSGSTGQPKGVMVRHRALTNF 682
Cdd:cd05945     84 LDAAKPALLIA--------------------------------------DGDDNAYIIFTSGSTGRPKGVQISHDNLVSF 125

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  683 VCSIARQPGMLARDRLLSVTTFSFDIFGLELYVPLARGASMLLASREQAQDPEALLDLVERQGVTVLQATPATWRMLC-- 760
Cdd:cd05945    126 TNWMLSDFPLGPGDVFLNQAPFSFDLSVMDLYPALASGATLVPVPRDATADPKQLFRFLAEHGITVWVSTPSFAAMCLls 205

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  761 ---DSERVDLLRGcTLLCGgEALAEDLAARMRGL--SASTWNLYGPTETTIWSARFRLGEEA-----RPFLGGPLENTAL 830
Cdd:cd05945    206 ptfTPESLPSLRH-FLFCG-EVLPHKTARALQQRfpDARIYNTYGPTEATVAVTYIEVTPEVldgydRLPIGYAKPGAKL 283

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  831 YILDSEMNPCPPGVAGELLIGGDGLARGYHRRPGLTAERFLPDpfaaDGSRLYRTGDLARYRADGVIEYLGRIDHQVKIR 910
Cdd:cd05945    284 VILDEDGRPVPPGEKGELVISGPSVSKGYLNNPEKTAAAFFPD----EGQRAYRTGDLVRLEADGLLFYRGRLDFQVKLN 359

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  911 GFRIELGEIETRLLEQDSVREAVVVAQP-GVAGPTLVAYLVPTEAALvdaesarqQELRSALKNSLLAVLPDYMVPAHML 989
Cdd:cd05945    360 GYRIELEEIEAALRQVPGVKEAVVVPKYkGEKVTELIAFVVPKPGAE--------AGLTKAIKAELAERLPPYMIPRRFV 431

                          490
                   ....*....|....*...
gi 2183974163  990 LLENLPLTPNGKINRKAL 1007
Cdd:cd05945    432 YLDELPLNANGKIDRKAL 449

SgcC5_NRPS-like

SgcC5 is a non-ribosomal peptide synthetase (NRPS) condensation enzyme with ester- and amide- ...

47-477

6.13e-107

SgcC5 is a non-ribosomal peptide synthetase (NRPS) condensation enzyme with ester- and amide- bond forming activity and similar C-domains of modular NRPSs; SgcC5 is a free-standing NRPS condensation enzyme (rather than a modular NRPS), which catalyzes the condensation between the SgcC2-tethered (S)-3-chloro-5-hydroxy-beta-tyrosine and (R)-1phenyl-1,2-ethanediol, forming an ester bond, during the synthesis of the chromoprotein enediyne antitumor antibiotic C-1027. It has some acceptor substrate promiscuity as it has been shown to also catalyze the formation of an amide bond between SgcC2-tethered (S)-3-chloro-5-hydroxy-beta-tyrosine and a mimic of the enediyne core acceptor substrate having an amine at its C-2 position. This subfamily also includes similar C-domains of modular NRPSs such as Penicillium chrysogenum N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase PCBAB. Condensation (C) domains of NRPSs normally catalyze peptide bond formation within (usually) large multi-modular enzymatic complexes. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long (with various activities such as antibiotic, antifungal, antitumor and immunosuppression). There are various subtypes of C-domains such as the LCL-type which catalyzes peptide bond formation between two L-amino acids, the DCL-type which links an L-amino acid to the D-amino acid at the end of a growing peptide, starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and heterocyclization (Cyc) domains which catalyze both peptide bond formation and cyclization of Cys, Ser, or Thr residues. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the epimerization (E) domain, the ester-bond forming C-domain, dual E/C (epimerization and condensation) domains, and the X-domain. C-domains typically have a conserved HHxxxD motif at the active site; mutations in this motif can abolish or diminish condensation activity.

Pssm-ID: 380462 [Multi-domain] Cd Length: 427 Bit Score: 349.76 E-value: 6.13e-107

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163   47 RIPLSYAQERQWFLWQMDPQSAAYNIPSALRLRGELDVEALSASLGAIVERHQSLRTVFVEDEQlDGFRQQVLASVDVPV 126
Cdd:cd19539      1 RIPLSFAQERLWFIDQGEDGGPAYNIPGAWRLTGPLDVEALREALRDVVARHEALRTLLVRDDG-GVPRQEILPPGPAPL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  127 PVTL--AGDDDAQAQIRAFVESETQQPFDLRNGPLLRARLLRLAADDHVLTLTIHHVAADGWSMRVLVEELIALYGARRQ 204
Cdd:cd19539     80 EVRDlsDPDSDRERRLEELLRERESRGFDLDEEPPIRAVLGRFDPDDHVLVLVAHHTAFDAWSLDVFARDLAALYAARRK 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  205 GIEATLPDLPIQYADYAIWQRHWLEAGERERQLEYWMARLGGGQsVLELPTDRQRPALPSYRGARHELQLPQALGRQLQA 284
Cdd:cd19539    160 GPAAPLPELRQQYKEYAAWQREALAAPRAAELLDFWRRRLRGAE-PTALPTDRPRPAGFPYPGADLRFELDAELVAALRE 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  285 LAQREGTTLFMLLLASFQALLHRYSGQDEIRVGVPVANRNRVETERLIGFFVNTQVLRADLDAQMPFLDLLQQTRVAALG 364
Cdd:cd19539    239 LAKRARSSLFMVLLAAYCVLLRRYTGQTDIVVGTPVAGRNHPRFESTVGFFVNLLPLRVDVSDCATFRDLIARVRKALVD 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  365 AQSHQDLPFEQLVEALQPERSLSHSPLFQAMYNHQNLGSAGRqslaAQLPGLSVEDLSWGAHSAQFDLTLDTYESEQGVH 444
Cdd:cd19539    319 AQRHQELPFQQLVAELPVDRDAGRHPLVQIVFQVTNAPAGEL----ELAGGLSYTEGSDIPDGAKFDLNLTVTEEGTGLR 394

                          410       420       430
                   ....*....|....*....|....*....|...
gi 2183974163  445 AEFTYATDLFEAATVERLARHWRNLLEAVVAEP 477
Cdd:cd19539    395 GSLGYATSLFDEETIQGFLADYLQVLRQLLANP 427

MenE/FadK

COG0318

O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) [Lipid ...

512-1007

3.97e-106

Pssm-ID: 440087 [Multi-domain] Cd Length: 452 Bit Score: 348.34 E-value: 3.97e-106

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  512 VHRLFEAQAGLTPDAPALLFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLD 591
Cdd:COG0318      1 LADLLRRAAARHPDRPALVFGGRRLTYAELDARARRLAAALRALGVGPGDRVALLLPNSPEFVVAFLAALRAGAVVVPLN 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  592 PQYPADRLQYMIDDSGLRLLLSqqsvlarlpqsdglqslllddlerlvhgypaenpdlpeapdslCYAIYTSGSTGQPKG 671
Cdd:COG0318     81 PRLTAEELAYILEDSGARALVT-------------------------------------------ALILYTSGTTGRPKG 117

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  672 VMVRHRALTNFVCSIARQPGMLARDRLLSVTTFSFDiFGL--ELYVPLARGASMLLASReqaQDPEALLDLVERQGVTVL 749
Cdd:COG0318    118 VMLTHRNLLANAAAIAAALGLTPGDVVLVALPLFHV-FGLtvGLLAPLLAGATLVLLPR---FDPERVLELIERERVTVL 193

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  750 QATPATWRMLC---DSERVDL--LRgcTLLCGGEALAEDLAARMRGLSAST-WNLYGPTETT--IWSARFRLGEEARPFL 821
Cdd:COG0318    194 FGVPTMLARLLrhpEFARYDLssLR--LVVSGGAPLPPELLERFEERFGVRiVEGYGLTETSpvVTVNPEDPGERRPGSV 271

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  822 GGPLENTALYILDSEMNPCPPGVAGELLIGGDGLARGYHRRPGLTAERFlpdpfaADGsrLYRTGDLARYRADGVIEYLG 901
Cdd:COG0318    272 GRPLPGVEVRIVDEDGRELPPGEVGEIVVRGPNVMKGYWNDPEATAEAF------RDG--WLRTGDLGRLDEDGYLYIVG 343

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  902 RIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQPG-VAGPTLVAYLVPTEAALVDAEsarqqELRSALKnsllAVLP 980
Cdd:COG0318    344 RKKDMIISGGENVYPAEVEEVLAAHPGVAEAAVVGVPDeKWGERVVAFVVLRPGAELDAE-----ELRAFLR----ERLA 414

                          490       500
                   ....*....|....*....|....*..
gi 2183974163  981 DYMVPAHMLLLENLPLTPNGKINRKAL 1007
Cdd:COG0318    415 RYKVPRRVEFVDELPRTASGKIDRRAL 441

SgcC5_NRPS-like

SgcC5 is a non-ribosomal peptide synthetase (NRPS) condensation enzyme with ester- and amide- ...

1112-1535

7.77e-106

Pssm-ID: 380462 [Multi-domain] Cd Length: 427 Bit Score: 346.67 E-value: 7.77e-106

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1112 PQLSFAQERQWFIWRLDPHSAAYNIPVALRLKGPLRRDALQGALDLLVQRHETLRTTFVEHD-GAPRQVIHPTLPIAIEE 1190
Cdd:cd19539      2 IPLSFAQERLWFIDQGEDGGPAYNIPGAWRLTGPLDVEALREALRDVVARHEALRTLLVRDDgGVPRQEILPPGPAPLEV 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1191 RRPPVAGEDLKGLVET----EAHRPFDLQRGPLLRVLLLPLATDECVLVLTLHHIIADGWSMQVLVDELIRVYAALRHDQ 1266
Cdd:cd19539     82 RDLSDPDSDRERRLEEllreRESRGFDLDEEPPIRAVLGRFDPDDHVLVLVAHHTAFDAWSLDVFARDLAALYAARRKGP 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1267 PPALAELPIQYADFAAWQRQWMDGGERERQLDYWVSRLGGEQPLlELPSDRPRPQQQSHRGRRIGIPLPAELAEALRRLA 1346
Cdd:cd19539    162 AAPLPELRQQYKEYAAWQREALAAPRAAELLDFWRRRLRGAEPT-ALPTDRPRPAGFPYPGADLRFELDAELVAALRELA 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1347 QAEQGTLFMLLLASFQALLHRYSGQNDIRVGVPIANRNREETEGLIGFFVNTQVLRAELDGQLPFRELLRQVRQAVVEAQ 1426
Cdd:cd19539    241 KRARSSLFMVLLAAYCVLLRRYTGQTDIVVGTPVAGRNHPRFESTVGFFVNLLPLRVDVSDCATFRDLIARVRKALVDAQ 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1427 GHQDLPFEQLVDALQPERSLSHAPLFQVMYNHQRDDHRGSRFASLGELEVEDLAWDvqTAQFDLTLDTYESSNGLLAELT 1506
Cdd:cd19539    321 RHQELPFQQLVAELPVDRDAGRHPLVQIVFQVTNAPAGELELAGGLSYTEGSDIPD--GAKFDLNLTVTEEGTGLRGSLG 398

                          410       420
                   ....*....|....*....|....*....
gi 2183974163 1507 YATDLFDASSAERIAGHWLNLLRSIVARP 1535
Cdd:cd19539    399 YATSLFDEETIQGFLADYLQVLRQLLANP 427

alpha_am_amid

TIGR03443

L-aminoadipate-semialdehyde dehydrogenase; Members of this protein family are ...

240-1095

9.91e-100

L-aminoadipate-semialdehyde dehydrogenase; Members of this protein family are L-aminoadipate-semialdehyde dehydrogenase (EC 1.2.1.31), product of the LYS2 gene. It is also called alpha-aminoadipate reductase. In fungi, lysine is synthesized via aminoadipate. Currently, all members of this family are fungal.

Pssm-ID: 274582 [Multi-domain] Cd Length: 1389 Bit Score: 355.14 E-value: 9.91e-100

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  240 WMARLGGgQSVLELPTDRQRPALPSYRGARHELQLPQALGrqlqalAQREGTTLFMLLLASFQALLHRYSGQDEIRVGVP 319
Cdd:TIGR03443    2 WSERLDN-PTLSVLPHDYLRPANNRLVEATYSLQLPSAEV------TAGGGSTPFIILLAAFAALVYRLTGDEDIVLGTS 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  320 VANRNRVeterligffvntQVLRADLDAQMPFLDLLQQTRVAALGAQSHQDLPFEQLVEALQPERSL-SHSPLFQAMYNH 398
Cdd:TIGR03443   75 SNKSGRP------------FVLRLNITPELSFLQLYAKVSEEEKEGASDIGVPFDELSEHIQAAKKLeRTPPLFRLAFQD 142

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  399 QNlgsagrqslAAQLPGLSVEDLSwgahsaqfDLTLDTYESEQGVHAEFTYATDLFEAATVERLARHWRNLLEAVVAEPR 478
Cdd:TIGR03443  143 AP---------DNQQTTYSTGSTT--------DLTVFLTPSSPELELSIYYNSLLFSSDRITIVADQLAQLLSAASSNPD 205

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  479 RRLGDLPLLdaeeraTLLQRSRLPA-------SEYPAGqgVHRLFEAQAGLTPD------APALLFGEER---LSYAELN 542
Cdd:TIGR03443  206 EPIGKVSLI------TPSQKSLLPDptkdldwSGFRGA--IHDIFADNAEKHPDrtcvveTPSFLDPSSKtrsFTYKQIN 277

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  543 ALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQYMIDDSGLRLLLS-------QQ 615
Cdd:TIGR03443  278 EASNILAHYLLKTGIKRGDVVMIYAYRGVDLVVAVMGVLKAGATFSVIDPAYPPARQTIYLSVAKPRALIViekagtlDQ 357

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  616 SV----------LARLP----QSDG------LQSLLLDDLERLVHgYPAENPDLPEAPDSLCYAIYTSGSTGQPKGVMVR 675
Cdd:TIGR03443  358 LVrdyidkelelRTEIPalalQDDGslvggsLEGGETDVLAPYQA-LKDTPTGVVVGPDSNPTLSFTSGSEGIPKGVLGR 436

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  676 HRALTNFVCSIARQPGMLARDRLLSVTTFSFDIFGLELYVPLARGASMLLASREQAQDPEALLDLVERQGVTVLQATPAT 755
Cdd:TIGR03443  437 HFSLAYYFPWMAKRFGLSENDKFTMLSGIAHDPIQRDMFTPLFLGAQLLVPTADDIGTPGRLAEWMAKYGATVTHLTPAM 516

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  756 WRMLCDSERV------------DLL--RGCTLLcggEALAEDLaarmrglsaSTWNLYGPTETTIWSARFRLGEEAR--P 819
Cdd:TIGR03443  517 GQLLSAQATTpipslhhaffvgDILtkRDCLRL---QTLAENV---------CIVNMYGTTETQRAVSYFEIPSRSSdsT 584

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  820 FL---------GGPLENTALYILD--SEMNPCPPGVAGELLIGGDGLARGYHRRPGLTAERFLPDPFAADGS-------- 880
Cdd:TIGR03443  585 FLknlkdvmpaGKGMKNVQLLVVNrnDRTQTCGVGEVGEIYVRAGGLAEGYLGLPELNAEKFVNNWFVDPSHwidldken 664

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  881 -------------RLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAV-VVAQPGVAGPTLV 946
Cdd:TIGR03443  665 nkperefwlgprdRLYRTGDLGRYLPDGNVECCGRADDQVKIRGFRIELGEIDTHLSQHPLVRENVtLVRRDKDEEPTLV 744

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  947 AYLVPTE--------AALVDAESA---------RQQELRSALKNSLLAVLPDYMVPAHMLLLENLPLTPNGKINRKALPL 1009
Cdd:TIGR03443  745 SYIVPQDksdeleefKSEVDDEESsdpvvkgliKYRKLIKDIREYLKKKLPSYAIPTVIVPLKKLPLNPNGKVDKPALPF 824

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1010 PDASAV------RDAHVAPE--GELERAMAAIWSEVL--KLGHIGRDDNFFELGGHSLLVTQVVSRVRRRLDLQVPLRTL 1079
Cdd:TIGR03443  825 PDTAQLaavaknRSASAADEefTETEREIRDLWLELLpnRPATISPDDSFFDLGGHSILATRMIFELRKKLNVELPLGLI 904

                          970
                   ....*....|....*.
gi 2183974163 1080 FEHSTLRAYAQAVAQL 1095
Cdd:TIGR03443  905 FKSPTIKGFAKEVDRL 920

PRK12316

peptide synthase; Provisional

2627-3183

3.65e-92

peptide synthase; Provisional

Pssm-ID: 237054 [Multi-domain] Cd Length: 5163 Bit Score: 337.70 E-value: 3.65e-92

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2627 LPLAAG-EVEDLYPLSPMQQGMLFHSLYQQNSGDYINQMRLDVEG-LDPQRFREAWQAALDAHEVLRSGFLwQGALEKPL 2704
Cdd:PRK12316    38 FPIPAGvSSAERDRLSYAQQRMWFLWQLEPQSGAYNLPSAVRLNGpLDRQALERAFASLVQRHETLRTVFP-RGADDSLA 116

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2705 QLVRKR-VEVPFSVHDWRDRADLAEALDALAAGEAGLGFELAEAPLLRLVLVRTGERRHHLIYTNHHILMDGWSNSQLLG 2783
Cdd:PRK12316   117 QVPLDRpLEVEFEDCSGLPEAEQEARLRDEAQRESLQPFDLCEGPLLRVRLLRLGEEEHVLLLTLHHIVSDGWSMNVLIE 196

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2784 EVLQRYRGETPSRSDG------RYRDYI----AWLQRQDAGRTEAFWKqrlQRLGE--PTLLVPA-----FAHGVRGaeg 2846
Cdd:PRK12316   197 EFSRFYSAYATGAEPGlpalpiQYADYAlwqrSWLEAGEQERQLEYWR---AQLGEehPVLELPTdhprpAVPSYRG--- 270

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2847 haDRYR-QLDVTTSQRLAEFAREQKVTLNTLVQAAWLILLQRFTGQDTVAFGATVSGRP-AELRGIeeqIGLFINTLPVV 2924
Cdd:PRK12316   271 --SRYEfSIDPALAEALRGTARRQGLTLFMLLLGAFNVLLHRYSGQTDIRVGVPIANRNrAEVEGL---IGFFVNTQVLR 345

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2925 ASPCPEQPIGDWLQAVQGENL---------------AL---REFEHTPLYDIqrwagqvgealfdnilVFENYPVSAALA 2986
Cdd:PRK12316   346 SVFDGRTRVATLLAGVKDTVLgaqahqdlpferlveALkveRSLSHSPLFQV----------------MYNHQPLVADIE 409

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2987 E-ETPADMRIDALSNQEQT-HYPLTL-LVSAGETLELHYSYSRQAFDEAAIECLAERLERLLLGMCENPGASLGELDSLA 3063
Cdd:PRK12316   410 AlDTVAGLEFGQLEWKSRTtQFDLTLdTYEKGGRLHAALTYATDLFEARTVERMARHWQNLLRGMVENPQARVDELPMLD 489

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3064 VAERYQLLEGWNATAAEYPLQRGVHRLFEEQVERTPTAPALAFGEERLDYAELNRRANRLAHALIERGIGADRLVGVAME 3143
Cdd:PRK12316   490 AEERGQLVEGWNATAAEYPLQRGVHRLFEEQVERTPEAPALAFGEETLDYAELNRRANRLAHALIERGVGPDVLVGVAME 569

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|
gi 2183974163 3144 RSIEMVVALMAILKAGGAYVPVDPEYPEERQAYMLEDSGV 3183
Cdd:PRK12316   570 RSIEMVVALLAILKAGGAYVPLDPEYPAERLAYMLEDSGV 609

alpha_am_amid

TIGR03443

L-aminoadipate-semialdehyde dehydrogenase; Members of this protein family are ...

1300-2153

1.25e-86

Pssm-ID: 274582 [Multi-domain] Cd Length: 1389 Bit Score: 314.31 E-value: 1.25e-86

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1300 WVSRLGgEQPLLELPSDRPRPQQQSHrgrrigipLPAELAEALRRLAQAEQG--TLFMLLLASFQALLHRYSGQNDIRVG 1377
Cdd:TIGR03443    2 WSERLD-NPTLSVLPHDYLRPANNRL--------VEATYSLQLPSAEVTAGGgsTPFIILLAAFAALVYRLTGDEDIVLG 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1378 VpianrnREETEGligffvNTQVLRAELDGQLPFRELLRQVRQAVVEAQGHQDLPFEQLVDALQPERSL-SHAPLFQVMY 1456
Cdd:TIGR03443   73 T------SSNKSG------RPFVLRLNITPELSFLQLYAKVSEEEKEGASDIGVPFDELSEHIQAAKKLeRTPPLFRLAF 140

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1457 NHQRDDhrgsrfaSLGELEVEDLAwdvqtaqfDLTLDTYESSNGLLAELTYATDLFDASSAERIAGHWLNLLRSIVARPE 1536
Cdd:TIGR03443  141 QDAPDN-------QQTTYSTGSTT--------DLTVFLTPSSPELELSIYYNSLLFSSDRITIVADQLAQLLSAASSNPD 205

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1537 ARIAELKLLDEAEaRADL------LQWNpgpqDFTpaSCLHRLIERQAAERPRATAVV---------YGERALDYGELNL 1601
Cdd:TIGR03443  206 EPIGKVSLITPSQ-KSLLpdptkdLDWS----GFR--GAIHDIFADNAEKHPDRTCVVetpsfldpsSKTRSFTYKQINE 278

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1602 RANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGYMIEDSGIRLLLTQRAA------ 1675
Cdd:TIGR03443  279 ASNILAHYLLKTGIKRGDVVMIYAYRGVDLVVAVMGVLKAGATFSVIDPAYPPARQTIYLSVAKPRALIVIEKAgtldql 358

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1676 -----RERLPLGEGLPCL-LLDAEHEWAGYPESD------PQSA---------VGVDNLAYVIYTSGSTGKPKGTLLPHG 1734
Cdd:TIGR03443  359 vrdyiDKELELRTEIPALaLQDDGSLVGGSLEGGetdvlaPYQAlkdtptgvvVGPDSNPTLSFTSGSEGIPKGVLGRHF 438

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1735 NVLRLFDATRHWFGFSADDAWSLFHSYAFDFSVWEIFGALLHGGRLVIVPYETSRSPEDFLRLLCRERVTVLNQTPsAFK 1814
Cdd:TIGR03443  439 SLAYYFPWMAKRFGLSENDKFTMLSGIAHDPIQRDMFTPLFLGAQLLVPTADDIGTPGRLAEWMAKYGATVTHLTP-AMG 517

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1815 QLMqVACAGQEVPplALRHVVFGGEAL------EVQALrpwferfgdrAP--RLVNMYGITETTVHVTY--------RPL 1878
Cdd:TIGR03443  518 QLL-SAQATTPIP--SLHHAFFVGDILtkrdclRLQTL----------AEnvCIVNMYGTTETQRAVSYfeipsrssDST 584

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1879 SLADLDGgaASPIGEPIPDLSwyLLDAGLNPVPRGC----IGELYVGGAGLARGYLNRPELSCTRFVADPFSTTG----- 1949
Cdd:TIGR03443  585 FLKNLKD--VMPAGKGMKNVQ--LLVVNRNDRTQTCgvgeVGEIYVRAGGLAEGYLGLPELNAEKFVNNWFVDPShwidl 660

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1950 ----------------GRLYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVVL-PHEGPGA 2012
Cdd:TIGR03443  661 dkennkperefwlgprDRLYRTGDLGRYLPDGNVECCGRADDQVKIRGFRIELGEIDTHLSQHPLVRENVTLvRRDKDEE 740

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2013 TQLVGYVVTQ---------------AAPSDPA--------ALRDTLRQALKASLPEHMVPAHLLFLERLPLTANGKLDRR 2069
Cdd:TIGR03443  741 PTLVSYIVPQdksdeleefksevddEESSDPVvkglikyrKLIKDIREYLKKKLPSYAIPTVIVPLKKLPLNPNGKVDKP 820

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2070 ALPAPD------ASRLQRDYTAPR--SELEQRLAAIWADVL--KLGRVGLDDNFFELGGDSIISIQVVSRARQAGIRLAP 2139
Cdd:TIGR03443  821 ALPFPDtaqlaaVAKNRSASAADEefTETEREIRDLWLELLpnRPATISPDDSFFDLGGHSILATRMIFELRKKLNVELP 900

                          970
                   ....*....|....*
gi 2183974163 2140 RDL-FLHQTIRGLAG 2153
Cdd:TIGR03443  901 LGLiFKSPTIKGFAK 915

C_PKS-NRPS_PksJ-like

Condensation domain of hybrid polyketide synthetase/nonribosomal peptide synthetases (PKS ...

1111-1535

8.24e-85

Condensation domain of hybrid polyketide synthetase/nonribosomal peptide synthetases (PKS/NRPSs), similar to Bacillus subtilis PksJ; Condensation (C) domains of nonribosomal peptide synthetases (NRPSs) catalyze peptide bond formation within (usually) large multi-modular enzymatic complexes. Hybrid PKS/NRPS create polymers containing both polyketide and amide linkages. C-domains typically have a conserved HHxxxD motif at the active site; mutations in this motif can abolish or diminish condensation activity. Members of this subfamily have the typical C-domain HHxxxD motif. PksJ is involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is important in secondary metabolism. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long (with various activities such as antibiotic, antifungal, antitumor and immunosuppression). There are various subtypes of C-domains such as the LCL-type which catalyzes peptide bond formation between two L-amino acids, the DCL-type which links an L-amino acid to the D-amino acid at the end of a growing peptide, starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and heterocyclization (Cyc) domains which catalyze both peptide bond formation and cyclization of Cys, Ser, or Thr residues. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the epimerization (E) domain, the ester-bond forming C-domain, dual E/C (epimerization and condensation) domains, and the X-domain.

Pssm-ID: 380472 [Multi-domain] Cd Length: 430 Bit Score: 286.13 E-value: 8.24e-85

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1111 SPQLSFAQERQWFIWRLDPHSAAYNIPVALRLKGPLRRDALQGALDLLVQRHETLRTTFVEHDGAPRQVIHPTLPIAI-E 1189
Cdd:cd20484      1 RSPLSEGQKGLWMLQKMSPEMSAYNVPLCFRFSSKLDVEKFKQACQFVLEQHPILKSVIEEEDGVPFQKIEPSKPLSFqE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1190 ERRPPVAGEDLKGLVETEAHRPFDLQRGPLLRVLLLPLATDECVLVLTLHHIIADGWSMQVLVDELIRVYAALRHDQPPA 1269
Cdd:cd20484     81 EDISSLKESEIIAYLREKAKEPFVLENGPLMRVHLFSRSEQEHFVLITIHHIIFDGSSSLTLIHSLLDAYQALLQGKQPT 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1270 LAELPIQYADFAAWQRQWMDGGERERQLDYWVSRLGGEQPLLELPSDRPRPQQQSHRGRRIGIPLPAELAEALRRLAQAE 1349
Cdd:cd20484    161 LASSPASYYDFVAWEQDMLAGAEGEEHRAYWKQQLSGTLPILELPADRPRSSAPSFEGQTYTRRLPSELSNQIKSFARSQ 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1350 QGTLFMLLLASFQALLHRYSGQNDIRVGVPIANRNREETEGLIGFFVNTQVLRAELDGQLPFRELLRQVRQAVVEAQGHQ 1429
Cdd:cd20484    241 SINLSTVFLGIFKLLLHRYTGQEDIIVGMPTMGRPEERFDSLIGYFINMLPIRSRILGEETFSDFIRKLQLTVLDGLDHA 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1430 DLPFEQLVDALQPERSLSHAPLFQVMYNHQRDDHRGS------RFASLGELE-VEDLAwdvQTAQFDLTLDTYESSNGLL 1502
Cdd:cd20484    321 AYPFPAMVRDLNIPRSQANSPVFQVAFFYQNFLQSTSlqqflaEYQDVLSIEfVEGIH---QEGEYELVLEVYEQEDRFT 397

                          410       420       430
                   ....*....|....*....|....*....|...
gi 2183974163 1503 AELTYATDLFDASSAERIAGHWLNLLRSIVARP 1535
Cdd:cd20484    398 LNIKYNPDLFDASTIERMMEHYVKLAEELIANP 430

PRK04813

D-alanine--poly(phosphoribitol) ligase subunit DltA;

1574-2071

1.60e-84

D-alanine--poly(phosphoribitol) ligase subunit DltA;

Pssm-ID: 235313 [Multi-domain] Cd Length: 503 Bit Score: 287.95 E-value: 1.60e-84

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1574 IERQAAERPRATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYP 1653
Cdd:PRK04813     8 IEEFAQTQPDFPAYDYLGEKLTYGQLKEDSDALAAFIDSLKLPDKSPIIVFGHMSPEMLATFLGAVKAGHAYIPVDVSSP 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1654 SDRLGYMIEDSGIRLLLtqraARERLPLG-EGLPCLLLDA-EHEWAGYPESDPQSAVGVDNLAYVIYTSGSTGKPKGTLL 1731
Cdd:PRK04813    88 AERIEMIIEVAKPSLII----ATEELPLEiLGIPVITLDElKDIFATGNPYDFDHAVKGDDNYYIIFTSGTTGKPKGVQI 163

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1732 PHGNVLRLFDatrhW----FGFSADDAWSLFHSYAFDFSVWEIFGALLHGGRLVIVPYETSRSPEDFLRLLCRERVTVLN 1807
Cdd:PRK04813   164 SHDNLVSFTN----WmledFALPEGPQFLNQAPYSFDLSVMDLYPTLASGGTLVALPKDMTANFKQLFETLPQLPINVWV 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1808 QTPSaFKQ--LMQVACAGQEVPplALRHVVFGGEALEVQALRPWFERFGDraPRLVNMYGITETTVHVTYRPLSLADLDG 1885
Cdd:PRK04813   240 STPS-FADmcLLDPSFNEEHLP--NLTHFLFCGEELPHKTAKKLLERFPS--ATIYNTYGPTEATVAVTSIEITDEMLDQ 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1886 GAASPIGEPIPDLSWYLLDAGLNPVPRGCIGELYVGGAGLARGYLNRPELSCTRFvadpFSTTGGRLYRTGDLARYRcDG 1965
Cdd:PRK04813   315 YKRLPIGYAKPDSPLLIIDEEGTKLPDGEQGEIVISGPSVSKGYLNNPEKTAEAF----FTFDGQPAYHTGDAGYLE-DG 389

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1966 VVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVVLPHEGPG-ATQLVGYVVTQAAP-SDPAALRDTLRQALKASL 2043
Cdd:PRK04813   390 LLFYQGRIDFQIKLNGYRIELEEIEQNLRQSSYVESAVVVPYNKDHkVQYLIAYVVPKEEDfEREFELTKAIKKELKERL 469

                          490       500
                   ....*....|....*....|....*...
gi 2183974163 2044 PEHMVPAHLLFLERLPLTANGKLDRRAL 2071
Cdd:PRK04813   470 MEYMIPRKFIYRDSLPLTPNGKIDRKAL 497

C_PKS-NRPS_PksJ-like

Condensation domain of hybrid polyketide synthetase/nonribosomal peptide synthetases (PKS ...

47-477

3.47e-81

Pssm-ID: 380472 [Multi-domain] Cd Length: 430 Bit Score: 275.73 E-value: 3.47e-81

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163   47 RIPLSYAQERQWFLWQMDPQSAAYNIPSALRLRGELDVEALSASLGAIVERHQSLRTVFVEDEQLdGFRQQVLASvdvpv 126
Cdd:cd20484      1 RSPLSEGQKGLWMLQKMSPEMSAYNVPLCFRFSSKLDVEKFKQACQFVLEQHPILKSVIEEEDGV-PFQKIEPSK----- 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  127 PVTLAGDDDA---QAQIRAFVESETQQPFDLRNGPLLRARLLRLAADDHVLTLTIHHVAADGWSMRVLVEELIALYGARR 203
Cdd:cd20484     75 PLSFQEEDISslkESEIIAYLREKAKEPFVLENGPLMRVHLFSRSEQEHFVLITIHHIIFDGSSSLTLIHSLLDAYQALL 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  204 QGIEATLPDLPIQYADYAIWQRHWLEAGERERQLEYWMARLGGGQSVLELPTDRQRPALPSYRGARHELQLPQALGRQLQ 283
Cdd:cd20484    155 QGKQPTLASSPASYYDFVAWEQDMLAGAEGEEHRAYWKQQLSGTLPILELPADRPRSSAPSFEGQTYTRRLPSELSNQIK 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  284 ALAQREGTTLFMLLLASFQALLHRYSGQDEIRVGVPVANRNRVETERLIGFFVNTQVLRADLDAQMPFLDLLQQTRVAAL 363
Cdd:cd20484    235 SFARSQSINLSTVFLGIFKLLLHRYTGQEDIIVGMPTMGRPEERFDSLIGYFINMLPIRSRILGEETFSDFIRKLQLTVL 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  364 GAQSHQDLPFEQLVEALQPERSLSHSPLFQAMYNHQN-LGSAGRQSLAAQL-PGLSVEDLSWGAHSAQFDLTLDTYESEQ 441
Cdd:cd20484    315 DGLDHAAYPFPAMVRDLNIPRSQANSPVFQVAFFYQNfLQSTSLQQFLAEYqDVLSIEFVEGIHQEGEYELVLEVYEQED 394

                          410       420       430
                   ....*....|....*....|....*....|....*.
gi 2183974163  442 GVHAEFTYATDLFEAATVERLARHWRNLLEAVVAEP 477
Cdd:cd20484    395 RFTLNIKYNPDLFDASTIERMMEHYVKLAEELIANP 430

C_PKS-NRPS

Condensation domain of hybrid polyketide synthetase/nonribosomal peptide synthetases (PKS ...

47-474

8.88e-81

Condensation domain of hybrid polyketide synthetase/nonribosomal peptide synthetases (PKS/NRPSs); Condensation (C) domains of nonribosomal peptide synthetases (NRPSs) catalyze peptide bond formation within (usually) large multi-modular enzymatic complexes. Hybrid PKS/NRPS create polymers containing both polyketide and amide linkages. C-domains typically have a conserved HHxxxD motif at the active site; mutations in this motif can abolish or diminish condensation activity. Most members of this subfamily have the typical C-domain HHXXXD motif. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long (with various activities such as antibiotic, antifungal, antitumor and immunosuppression). There are various subtypes of C-domains such as the LCL-type which catalyzes peptide bond formation between two L-amino acids, the DCL-type which links an L-amino acid to the D-amino acid at the end of a growing peptide, starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and heterocyclization (Cyc) domains which catalyze both peptide bond formation and cyclization of Cys, Ser, or Thr residues. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the epimerization (E) domain, the ester-bond forming C-domain, dual E/C (epimerization and condensation) domains, and the X-domain.

Pssm-ID: 380471 [Multi-domain] Cd Length: 430 Bit Score: 274.52 E-value: 8.88e-81

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163   47 RIPLSYAQERQWFLWQMDPQSAAYNIPSALRLRGELDVEALSASLGAIVERHQSLRTVFVEDEqlDGFRQQVLASVDVPV 126
Cdd:cd20483      1 PRPMSTFQRRLWFLHNFLEDKTFLNLLLVCHIKGKPDVNLLQKALSELVRRHEVLRTAYFEGD--DFGEQQVLDDPSFHL 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  127 PVT-LAGDDDAQAQIRAFVESETQQPFDLRNGPLLRARLLRLAADDHVLTLTIHHVAADGWSMRVLVEELIALYGA-RRQ 204
Cdd:cd20483     79 IVIdLSEAADPEAALDQLVRNLRRQELDIEEGEVIRGWLVKLPDEEFALVLASHHIAWDRGSSKSIFEQFTALYDAlRAG 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  205 GIEATLPDLPIQYADYAIWQRHWLEAGERERQLEYWMARLGGG-QSVLELP-TDRQRPALPSYRGARHELQLPQALGRQL 282
Cdd:cd20483    159 RDLATVPPPPVQYIDFTLWHNALLQSPLVQPLLDFWKEKLEGIpDASKLLPfAKAERPPVKDYERSTVEATLDKELLARM 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  283 QALAQREGTTLFMLLLASFQALLHRYSGQDEIRVGVPVANRNRVETERLIGFFVNTQVLRADLDAQMPFLDLLQQTRVAA 362
Cdd:cd20483    239 KRICAQHAVTPFMFLLAAFRAFLYRYTEDEDLTIGMVDGDRPHPDFDDLVGFFVNMLPIRCRMDCDMSFDDLLESTKTTC 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  363 LGAQSHQDLPFEQLVEALQPERSLSHSPLFQAMYNHQNLGSagrqslaaqLPGLSVED---LSWGAHSA--QFDLTLDTY 437
Cdd:cd20483    319 LEAYEHSAVPFDYIVDALDVPRSTSHFPIGQIAVNYQVHGK---------FPEYDTGDfkfTDYDHYDIptACDIALEAE 389

                          410       420       430
                   ....*....|....*....|....*....|....*...
gi 2183974163  438 ESEQ-GVHAEFTYATDLFEAATVERLARHWRNLLEAVV 474
Cdd:cd20483    390 EDPDgGLDLRLEFSTTLYDSADMERFLDNFVTFLTSVI 427

PRK04813

D-alanine--poly(phosphoribitol) ligase subunit DltA;

512-1007

2.59e-80

D-alanine--poly(phosphoribitol) ligase subunit DltA;

Pssm-ID: 235313 [Multi-domain] Cd Length: 503 Bit Score: 275.62 E-value: 2.59e-80

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  512 VHRLFE-AQAglTPDAPALLFGEERLSYAELNALANRLAWRLREEGV--GSDVLV--GIALErgvpMVVALLAVLKAGGA 586
Cdd:PRK04813     5 IETIEEfAQT--QPDFPAYDYLGEKLTYGQLKEDSDALAAFIDSLKLpdKSPIIVfgHMSPE----MLATFLGAVKAGHA 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  587 YVPLDPQYPADRLQYMIDDSGLRLLLSqqsvLARLPQS-DGLQSLLLDDLERLVHGYPAENPDLPEAPDSLCYAIYTSGS 665
Cdd:PRK04813    79 YIPVDVSSPAERIEMIIEVAKPSLIIA----TEELPLEiLGIPVITLDELKDIFATGNPYDFDHAVKGDDNYYIIFTSGT 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  666 TGQPKGVMVRHRALTNFVCSIARQPGMLARDRLLSVTTFSFDIFGLELYVPLARGASMLLASREQAQDPEALLDLVERQG 745
Cdd:PRK04813   155 TGKPKGVQISHDNLVSFTNWMLEDFALPEGPQFLNQAPYSFDLSVMDLYPTLASGGTLVALPKDMTANFKQLFETLPQLP 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  746 VTVLQATPATWRM------LCDSERVDLLRgcTLLCGgEAL----AEDLaaRMRGLSASTWNLYGPTETTIWSARFRLGE 815
Cdd:PRK04813   235 INVWVSTPSFADMclldpsFNEEHLPNLTH--FLFCG-EELphktAKKL--LERFPSATIYNTYGPTEATVAVTSIEITD 309

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  816 EA-----RPFLGGPLENTALYILDSEMNPCPPGVAGELLIGGDGLARGYHRRPGLTAERFlpdpFAADGSRLYRTGDLAr 890
Cdd:PRK04813   310 EMldqykRLPIGYAKPDSPLLIIDEEGTKLPDGEQGEIVISGPSVSKGYLNNPEKTAEAF----FTFDGQPAYHTGDAG- 384

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  891 YRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVaqpgvagPT--------LVAYLVPTEAalvdaESA 962
Cdd:PRK04813   385 YLEDGLLFYQGRIDFQIKLNGYRIELEEIEQNLRQSSYVESAVVV-------PYnkdhkvqyLIAYVVPKEE-----DFE 452

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*
gi 2183974163  963 RQQELRSALKNSLLAVLPDYMVPAHMLLLENLPLTPNGKINRKAL 1007
Cdd:PRK04813   453 REFELTKAIKKELKERLMEYMIPRKFIYRDSLPLTPNGKIDRKAL 497

C_NRPS-like

Condensation domain of nonribosomal peptide synthetases (NRPSs); Condensation (C) domains of ...

1114-1535

2.60e-79

Condensation domain of nonribosomal peptide synthetases (NRPSs); Condensation (C) domains of nonribosomal peptide synthetases (NRPSs) catalyze peptide bond formation within (usually) large multi-modular enzymatic complexes. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long, with various activities such as antibiotic, antifungal, antitumor and immunosuppression. There are various subtypes of C-domains such as the LCL-type which catalyzes peptide bond formation between two L-amino acids, the DCL-type which links an L-amino acid to the D-amino acid at the end of a growing peptide, starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and heterocyclization (Cyc) domains which catalyze both peptide bond formation and cyclization of Cys, Ser, or Thr residues. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the epimerization (E) domain, the ester-bond forming C-domain, dual E/C (epimerization and condensation) domains, and the X-domain. C-domains typically have a conserved HHxxxD motif at the active site; mutations in this motif can abolish or diminish condensation activity.

Pssm-ID: 380453 [Multi-domain] Cd Length: 427 Bit Score: 270.05 E-value: 2.60e-79

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1114 LSFAQERQWFIWRLDPHSAAYNIPVALRLKGPLRRDALQGALDLLVQRHETLRTTFVEHDGAPRQVIHPTLPiaieerRP 1193
Cdd:cd19066      4 LSPMQRGMWFLKKLATDPSAFNVAIEMFLTGSLDLARLKQALDAVMERHDVLRTRFCEEAGRYEQVVLDKTV------RF 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1194 PVAGEDLKGLVETEA----------HRPFDLQRGPLLRVLLLPLATDECVLVLTLHHIIADGWSMQVLVDELIRVYAALR 1263
Cdd:cd19066     78 RIEIIDLRNLADPEArllelidqiqQTIYDLERGPLVRVALFRLADERDVLVVAIHHIIVDGGSFQILFEDISSVYDAAE 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1264 HDQPpALAELPIQYADFAAWQRQWMDGGERERQLDYWVSRLGGEQPLLELPSDRPRPQQQSHRGRRIGIPLPAELAEALR 1343
Cdd:cd19066    158 RQKP-TLPPPVGSYADYAAWLEKQLESEAAQADLAYWTSYLHGLPPPLPLPKAKRPSQVASYEVLTLEFFLRSEETKRLR 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1344 RLAQAEQGTLFMLLLASFQALLHRYSGQNDIRVGVPIANRNREETEGLIGFFVNTQVLRAELDGQLPFRELLRQVRQAVV 1423
Cdd:cd19066    237 EVARESGTTPTQLLLAAFALALKRLTASIDVVIGLTFLNRPDEAVEDTIGLFLNLLPLRIDTSPDATFPELLKRTKEQSR 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1424 EAQGHQDLPFEQLVDALQPERSLSHAPLFQVMYNHQrddhrgSRFASLGELEV-----EDLAWDvQTAQFDLTLDTYESS 1498
Cdd:cd19066    317 EAIEHQRVPFIELVRHLGVVPEAPKHPLFEPVFTFK------NNQQQLGKTGGfifttPVYTSS-EGTVFDLDLEASEDP 389

                          410       420       430
                   ....*....|....*....|....*....|....*...
gi 2183974163 1499 NG-LLAELTYATDLFDASSAERIAGHWLNLLRSIVARP 1535
Cdd:cd19066    390 DGdLLLRLEYSRGVYDERTIDRFAERYMTALRQLIENP 427

COG4908

Uncharacterized conserved protein, contains a NRPS condensation (elongation) domain [General ...

1114-1354

7.47e-79

Uncharacterized conserved protein, contains a NRPS condensation (elongation) domain [General function prediction only];

Pssm-ID: 443936 [Multi-domain] Cd Length: 243 Bit Score: 261.51 E-value: 7.47e-79

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1114 LSFAQERQWFiwrLDPHSAAYNIPVALRLKGPLRRDALQGALDLLVQRHETLRTTFVEHDGAPRQVIHPTLPIAIE---- 1189
Cdd:COG4908      1 LSPAQKRFLF---LEPGSNAYNIPAVLRLEGPLDVEALERALRELVRRHPALRTRFVEEDGEPVQRIDPDADLPLEvvdl 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1190 -ERRPPVAGEDLKGLVETEAHRPFDLQRGPLLRVLLLPLATDECVLVLTLHHIIADGWSMQVLVDELIRVYAALRHDQPP 1268
Cdd:COG4908     78 sALPEPEREAELEELVAEEASRPFDLARGPLLRAALIRLGEDEHVLLLTIHHIISDGWSLGILLRELAALYAALLEGEPP 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1269 ALAELPIQYADFAAWQRQWMDGGERERQLDYWVSRLGGEQPLLELPSDRPRPQQQSHRGRRIGIPLPAELAEALRRLAQA 1348
Cdd:COG4908    158 PLPELPIQYADYAAWQRAWLQSEALEKQLEYWRQQLAGAPPVLELPTDRPRPAVQTFRGATLSFTLPAELTEALKALAKA 237


                   ....*.
gi 2183974163 1349 EQGTLF 1354
Cdd:COG4908    238 HGATVN 243

C_PKS-NRPS

Condensation domain of hybrid polyketide synthetase/nonribosomal peptide synthetases (PKS ...

1114-1535

8.09e-77

Condensation domain of hybrid polyketide synthetase/nonribosomal peptide synthetases (PKS/NRPSs); Condensation (C) domains of nonribosomal peptide synthetases (NRPSs) catalyze peptide bond formation within (usually) large multi-modular enzymatic complexes. Hybrid PKS/NRPS create polymers containing both polyketide and amide linkages. C-domains typically have a conserved HHxxxD motif at the active site; mutations in this motif can abolish or diminish condensation activity. Most members of this subfamily have the typical C-domain HHxxxD motif, a few such as Monascus pilosus lovastatin nonaketide synthase MokA have a non-canonical HRxxxD motif in the C-domain and are unable to catalyze amide-bond formation. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long (with various activities such as antibiotic, antifungal, antitumor and immunosuppression). There are various subtypes of C-domains such as the LCL-type which catalyzes peptide bond formation between two L-amino acids, the DCL-type which links an L-amino acid to the D-amino acid at the end of a growing peptide, starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and heterocyclization (Cyc) domains which catalyze both peptide bond formation and cyclization of Cys, Ser, or Thr residues. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the epimerization (E) domain, the ester-bond forming C-domain, dual E/C (epimerization and condensation) domains, and the X-domain.

Pssm-ID: 380455 [Multi-domain] Cd Length: 421 Bit Score: 262.78 E-value: 8.09e-77

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1114 LSFAQERQWFIWRLDPHSAAYNIPVALRLKGPLRRDALQGALDLLVQRHETLRTTFV--EHDGAPRQVIHPTLPIAIEER 1191
Cdd:cd19532      4 MSFGQSRFWFLQQYLEDPTTFNVTFSYRLTGPLDVARLERAVRAVGQRHEALRTCFFtdPEDGEPMQGVLASSPLRLEHV 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1192 rpPVAGEDLkglVETEAHR----PFDLQRGPLLRVLLLPLATDECVLVLTLHHIIADGWSMQVLVDELIRVYAalrhDQP 1267
Cdd:cd19532     84 --QISDEAE---VEEEFERlknhVYDLESGETMRIVLLSLSPTEHYLIFGYHHIAMDGVSFQIFLRDLERAYN----GQP 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1268 paLAELPIQYADFAAWQRQWMDGGERERQLDYWVSRLGGEQ---PLLELPSDRPRPQQQSHRGRRIGIPLPAELAEALRR 1344
Cdd:cd19532    155 --LLPPPLQYLDFAARQRQDYESGALDEDLAYWKSEFSTLPeplPLLPFAKVKSRPPLTRYDTHTAERRLDAALAARIKE 232

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1345 LAQAEQGTLFMLLLASFQALLHRYSGQNDIRVGVPIANRNREETEGLIGFFVNTQVLRAELDGQLPFRELLRQVRQAVVE 1424
Cdd:cd19532    233 ASRKLRVTPFHFYLAALQVLLARLLDVDDICIGIADANRTDEDFMETIGFFLNLLPLRFRRDPSQTFADVLKETRDKAYA 312

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1425 AQGHQDLPFEQLVDALQPERSLSHAPLFQVMYNHqRDDHRGSRfaSLGELEVEDLAW-DVQTAqFDLTLDTYESSNG--L 1501
Cdd:cd19532    313 ALAHSRVPFDVLLDELGVPRSATHSPLFQVFINY-RQGVAESR--PFGDCELEGEEFeDARTP-YDLSLDIIDNPDGdcL 388

                          410       420       430
                   ....*....|....*....|....*....|....
gi 2183974163 1502 LaELTYATDLFDASSAERIAGHWLNLLRSIVARP 1535
Cdd:cd19532    389 L-TLKVQSSLYSEEDAELLLDSYVNLLEAFARDP 421

C_PKS-NRPS

Condensation domain of hybrid polyketide synthetase/nonribosomal peptide synthetases (PKS ...

49-477

9.15e-76

Condensation domain of hybrid polyketide synthetase/nonribosomal peptide synthetases (PKS/NRPSs); Condensation (C) domains of nonribosomal peptide synthetases (NRPSs) catalyze peptide bond formation within (usually) large multi-modular enzymatic complexes. Hybrid PKS/NRPS create polymers containing both polyketide and amide linkages. C-domains typically have a conserved HHxxxD motif at the active site; mutations in this motif can abolish or diminish condensation activity. Most members of this subfamily have the typical C-domain HHxxxD motif, a few such as Monascus pilosus lovastatin nonaketide synthase MokA have a non-canonical HRxxxD motif in the C-domain and are unable to catalyze amide-bond formation. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long (with various activities such as antibiotic, antifungal, antitumor and immunosuppression). There are various subtypes of C-domains such as the LCL-type which catalyzes peptide bond formation between two L-amino acids, the DCL-type which links an L-amino acid to the D-amino acid at the end of a growing peptide, starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and heterocyclization (Cyc) domains which catalyze both peptide bond formation and cyclization of Cys, Ser, or Thr residues. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the epimerization (E) domain, the ester-bond forming C-domain, dual E/C (epimerization and condensation) domains, and the X-domain.

Pssm-ID: 380455 [Multi-domain] Cd Length: 421 Bit Score: 259.70 E-value: 9.15e-76

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163   49 PLSYAQERQWFLWQMDPQSAAYNIPSALRLRGELDVEALSASLGAIVERHQSLRTVFVEDEQLDGFRQQVLA-SVDVPVP 127
Cdd:cd19532      3 PMSFGQSRFWFLQQYLEDPTTFNVTFSYRLTGPLDVARLERAVRAVGQRHEALRTCFFTDPEDGEPMQGVLAsSPLRLEH 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  128 VTLAGDDDAQAQIRAFVesetQQPFDLRNGPLLRARLLRLAADDHVLTLTIHHVAADGWSMRVLVEELIALYGARrqgie 207
Cdd:cd19532     83 VQISDEAEVEEEFERLK----NHVYDLESGETMRIVLLSLSPTEHYLIFGYHHIAMDGVSFQIFLRDLERAYNGQ----- 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  208 aTLPDLPIQYADYAIWQRHWLEAGERERQLEYWMARLGGGQSVLEL---PTDRQRPALPSYRGARHELQLPQALGRQLQA 284
Cdd:cd19532    154 -PLLPPPLQYLDFAARQRQDYESGALDEDLAYWKSEFSTLPEPLPLlpfAKVKSRPPLTRYDTHTAERRLDAALAARIKE 232

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  285 LAQREGTTLFMLLLASFQALLHRYSGQDEIRVGVPVANRNRVETERLIGFFVNTQVLRADLDAQMPFLDLLQQTRVAALG 364
Cdd:cd19532    233 ASRKLRVTPFHFYLAALQVLLARLLDVDDICIGIADANRTDEDFMETIGFFLNLLPLRFRRDPSQTFADVLKETRDKAYA 312

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  365 AQSHQDLPFEQLVEALQPERSLSHSPLFQAMYNHQnLGSAGRQSLA-AQLPGLSVEDlswgAHSAqFDLTLDTYESEQG- 442
Cdd:cd19532    313 ALAHSRVPFDVLLDELGVPRSATHSPLFQVFINYR-QGVAESRPFGdCELEGEEFED----ARTP-YDLSLDIIDNPDGd 386

                          410       420       430
                   ....*....|....*....|....*....|....*
gi 2183974163  443 VHAEFTYATDLFEAATVERLARHWRNLLEAVVAEP 477
Cdd:cd19532    387 CLLTLKVQSSLYSEEDAELLLDSYVNLLEAFARDP 421

C_NRPS-like

Condensation domain of nonribosomal peptide synthetases (NRPSs); Condensation (C) domains of ...

48-477

1.07e-75

Pssm-ID: 380453 [Multi-domain] Cd Length: 427 Bit Score: 259.65 E-value: 1.07e-75

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163   48 IPLSYAQERQWFLWQMDPQSAAYNIPSALRLRGELDVEALSASLGAIVERHQSLRTVFVED----EQ--LDGFRQQVLAS 121
Cdd:cd19066      2 IPLSPMQRGMWFLKKLATDPSAFNVAIEMFLTGSLDLARLKQALDAVMERHDVLRTRFCEEagryEQvvLDKTVRFRIEI 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  122 VDvpvpvtLAGDDDAQAQIRAFVESETQQPFDLRNGPLLRARLLRLAADDHVLTLTIHHVAADGWSMRVLVEELIALYGA 201
Cdd:cd19066     82 ID------LRNLADPEARLLELIDQIQQTIYDLERGPLVRVALFRLADERDVLVVAIHHIIVDGGSFQILFEDISSVYDA 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  202 RRQGiEATLPDLPIQYADYAIWQRHWLEAGERERQLEYWMARLGGGQSVLELPTDRQRPALPSYRGARHELQLPQALGRQ 281
Cdd:cd19066    156 AERQ-KPTLPPPVGSYADYAAWLEKQLESEAAQADLAYWTSYLHGLPPPLPLPKAKRPSQVASYEVLTLEFFLRSEETKR 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  282 LQALAQREGTTLFMLLLASFQALLHRYSGQDEIRVGVPVANRNRVETERLIGFFVNTQVLRADLDAQMPFLDLLQQTRVA 361
Cdd:cd19066    235 LREVARESGTTPTQLLLAAFALALKRLTASIDVVIGLTFLNRPDEAVEDTIGLFLNLLPLRIDTSPDATFPELLKRTKEQ 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  362 ALGAQSHQDLPFEQLVEALQPERSLSHSPLFQAMYN-HQNLGSAGRQSLAAqlpgLSVEDLSWgAHSAQFDLTLDTYE-S 439
Cdd:cd19066    315 SREAIEHQRVPFIELVRHLGVVPEAPKHPLFEPVFTfKNNQQQLGKTGGFI----FTTPVYTS-SEGTVFDLDLEASEdP 389

                          410       420       430
                   ....*....|....*....|....*....|....*...
gi 2183974163  440 EQGVHAEFTYATDLFEAATVERLARHWRNLLEAVVAEP 477
Cdd:cd19066    390 DGDLLLRLEYSRGVYDERTIDRFAERYMTALRQLIENP 427

X-Domain_NRPS

X-domain is a catalytically inactive Condensation-like domain shown to recruit oxygenases to ...

46-477

1.74e-74

X-domain is a catalytically inactive Condensation-like domain shown to recruit oxygenases to the non-ribosomal peptide synthetase (NRPS); The X-domain is a catalytically inactive member of the Condensation (C) domain family of non-ribosomal peptide synthetase (NRPS). It has been shown to recruit oxygenases to the NRPS to perform side-chain crosslinking in the production of glycopeptide antibiotics. C-domains of nonribosomal peptide synthetases (NRPSs) catalyze peptide bond formation within (usually) large multi-modular enzymatic complexes. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long (with various activities such as antibiotic, antifungal, antitumor and immunosuppression). There are various subtypes of C-domains such as the LCL-type which catalyzes peptide bond formation between two L-amino acids, the DCL-type which links an L-amino acid to the D-amino acid at the end of a growing peptide, starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and heterocyclization (Cyc) domains which catalyze both peptide bond formation and cyclization of Cys, Ser, or Thr residues. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as this X-domain, the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the epimerization (E) domain, the ester-bond forming C-domain, and dual E/C (epimerization and condensation) domains. C-domains typically have a conserved HHxxxD motif at the active site; mutations in this motif can abolish or diminish condensation activity; members of this X-domain subfamily lack the second H of this motif.

Pssm-ID: 380468 [Multi-domain] Cd Length: 440 Bit Score: 256.64 E-value: 1.74e-74

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163   46 ERIPLSYAQERQWFLWQMDPQSAAYNIPSALRLRGELDVEALSASLGAIVERHQSLRTVFVEDEQldGFRQQVL--ASVD 123
Cdd:cd19546      3 DEVPATAGQLRTWLLARLDEETRGRHLSVALRLRGRLDRDALEAALGDVAARHEILRTTFPGDGG--DVHQRILdaDAAR 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  124 VPVPVTLAGDDDAQAQIRAfvesETQQPFDLRNGPLLRARLLRLAADDHVLTLTIHHVAADGWSMRVLVEELIALYGARR 203
Cdd:cd19546     81 PELPVVPATEEELPALLAD----RAAHLFDLTRETPWRCTLFALSDTEHVLLLVVHRIAADDESLDVLVRDLAAAYGARR 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  204 QGIEATLPDLPIQYADYAIWQRHWLeAGERER------QLEYWMARLGGGQSVLELPTDRQRPALPSYRGARHELQLPQA 277
Cdd:cd19546    157 EGRAPERAPLPLQFADYALWERELL-AGEDDRdsligdQIAYWRDALAGAPDELELPTDRPRPVLPSRRAGAVPLRLDAE 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  278 LGRQLQALAQREGTTLFMLLLASFQALLHRYSGQDEIRVGVPVANRN-RVETERLIGFFVNTQVLRADLDAQMPFLDLLQ 356
Cdd:cd19546    236 VHARLMEAAESAGATMFTVVQAALAMLLTRLGAGTDVTVGTVLPRDDeEGDLEGMVGPFARPLALRTDLSGDPTFRELLG 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  357 QTRVAALGAQSHQDLPFEQLVEALQPERSLSHSPLFQAMYNHQNLGSAGRQSlaAQLPGLSVEDLSWGAHSAQFDLTLDT 436
Cdd:cd19546    316 RVREAVREARRHQDVPFERLAELLALPPSADRHPVFQVALDVRDDDNDPWDA--PELPGLRTSPVPLGTEAMELDLSLAL 393

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*..
gi 2183974163  437 YE------SEQGVHAEFTYATDLFEAATVERLARHWRNLLEAVVAEP 477
Cdd:cd19546    394 TErrnddgDPDGLDGSLRYAADLFDRATAAALARRLVRVLEQVAADP 440

Condensation

Condensation domain; This domain is found in many multi-domain enzymes which synthesize ...

2174-2614

2.24e-74

Pssm-ID: 395541 [Multi-domain] Cd Length: 454 Bit Score: 256.88 E-value: 2.24e-74

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2174 PLLPIQQ--MFFELDIPRRQHWNQSVLLEPGQALDGTLLETALQALLAHHDALRLGFRLEDGT----WRAEHRAVE-AGE 2246
Cdd:pfam00668    6 PLSPAQKrmWFLEKLEPHSSAYNMPAVLKLTGELDPERLEKALQELINRHDALRTVFIRQENGepvqVILEERPFElEII 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2247 VLLWQQSVADGQALEALAEQ-VQRSLDLGSGPLLRALLATLGDGSQRLLLVIHHLVVDGVSWRILLEDLQTAYRQLQAGQ 2325
Cdd:pfam00668   86 DISDLSESEEEEAIEAFIQRdLQSPFDLEKGPLFRAGLFRIAENRHHLLLSMHHIIVDGVSLGILLRDLADLYQQLLKGE 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2326 AVALPAKTSaFKAWAERLQAHARDGGLEGERGYWLAQLEG--VSTELPCDDREGAQsvRHVRSARTELT-EEATRRLLQE 2402
Cdd:pfam00668  166 PLPLPPKTP-YKDYAEWLQQYLQSEDYQKDAAYWLEQLEGelPVLQLPKDYARPAD--RSFKGDRLSFTlDEDTEELLRK 242

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2403 APAAYRTQVNDLLLTALARVIGRWTGQADTLIQLEGHGREElfEDIDltRTVGWFTSLFPLRL--SPVAELGASIKRIKE 2480
Cdd:pfam00668  243 LAKAHGTTLNDVLLAAYGLLLSRYTGQDDIVVGTPGSGRPS--PDIE--RMVGMFVNTLPLRIdpKGGKTFSELIKRVQE 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2481 QLR-AIPHKGLGFGALRYLgSAEDRAAL-AALPSPRITF-NYLGQFdgsfsaDSSALFRPSADAAGSERDSDAPLDNWLS 2557
Cdd:pfam00668  319 DLLsAEPHQGYPFGDLVND-LRLPRDLSrHPLFDPMFSFqNYLGQD------SQEEEFQLSELDLSVSSVIEEEAKYDLS 391

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2183974163 2558 LNGQVYAGRLGIDWSFSAARFSEASILRLADAYRDELLALIEHCCAADVEGVTPSDF 2614
Cdd:pfam00668  392 LTASERGGGLTIKIDYNTSLFDEETIERFAEHFKELLEQAIAHPSQPLSELDLLSDA 448

Condensation

Condensation domain; This domain is found in many multi-domain enzymes which synthesize ...

2634-3071

1.16e-73

Pssm-ID: 395541 [Multi-domain] Cd Length: 454 Bit Score: 254.57 E-value: 1.16e-73

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2634 VEDLYPLSPMQQGMLFHSLYQQNSGDYINQMRLDVEG-LDPQRFREAWQAALDAHEVLRSGFLWQgALEKPLQLVRKRVE 2712
Cdd:pfam00668    1 VQDEYPLSPAQKRMWFLEKLEPHSSAYNMPAVLKLTGeLDPERLEKALQELINRHDALRTVFIRQ-ENGEPVQVILEERP 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2713 VPFSVHDWRDRADLAEALDALAAGEAGL--GFELAEAPLLRLVLVRTGERRHHLIYTNHHILMDGWSNSQLLGEVLQRYR 2790
Cdd:pfam00668   80 FELEIIDISDLSESEEEEAIEAFIQRDLqsPFDLEKGPLFRAGLFRIAENRHHLLLSMHHIIVDGVSLGILLRDLADLYQ 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2791 G-----ETPSRSDGRYRDYIAWLQR----QDAGRTEAFWKQRLQRLGEPTLLVPAFAH-GVRGAEGHADRYRqLDVTTSQ 2860
Cdd:pfam00668  160 QllkgePLPLPPKTPYKDYAEWLQQylqsEDYQKDAAYWLEQLEGELPVLQLPKDYARpADRSFKGDRLSFT-LDEDTEE 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2861 RLAEFAREQKVTLNTLVQAAWLILLQRFTGQDTVAFGATVSGRPAElrGIEEQIGLFINTLPVVASPCPEQPIGDWLQAV 2940
Cdd:pfam00668  239 LLRKLAKAHGTTLNDVLLAAYGLLLSRYTGQDDIVVGTPGSGRPSP--DIERMVGMFVNTLPLRIDPKGGKTFSELIKRV 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2941 QGENLALREFEHTPLYDIQR----WAGQVGEALFDNILVFENYPVSAALAEE---TPADMRIDaLSNQEQTHYPLTLLVS 3013
Cdd:pfam00668  317 QEDLLSAEPHQGYPFGDLVNdlrlPRDLSRHPLFDPMFSFQNYLGQDSQEEEfqlSELDLSVS-SVIEEEAKYDLSLTAS 395

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2183974163 3014 -AGETLELHYSYSRQAFDEAAIECLAERLERLLLGMCENPGASLGELDSLAVAERYQLL 3071
Cdd:pfam00668  396 eRGGGLTIKIDYNTSLFDEETIERFAEHFKELLEQAIAHPSQPLSELDLLSDAEKQKLL 454

COG4908

Uncharacterized conserved protein, contains a NRPS condensation (elongation) domain [General ...

50-294

2.21e-73

Uncharacterized conserved protein, contains a NRPS condensation (elongation) domain [General function prediction only];

Pssm-ID: 443936 [Multi-domain] Cd Length: 243 Bit Score: 245.72 E-value: 2.21e-73

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163   50 LSYAQERQWFlwqMDPQSAAYNIPSALRLRGELDVEALSASLGAIVERHQSLRTVFVEDEqlDGFRQQVLASVDVPVPVT 129
Cdd:COG4908      1 LSPAQKRFLF---LEPGSNAYNIPAVLRLEGPLDVEALERALRELVRRHPALRTRFVEED--GEPVQRIDPDADLPLEVV 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  130 LAGD---DDAQAQIRAFVESETQQPFDLRNGPLLRARLLRLAADDHVLTLTIHHVAADGWSMRVLVEELIALYGARRQGI 206
Cdd:COG4908     76 DLSAlpePEREAELEELVAEEASRPFDLARGPLLRAALIRLGEDEHVLLLTIHHIISDGWSLGILLRELAALYAALLEGE 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  207 EATLPDLPIQYADYAIWQRHWLEAGERERQLEYWMARLGGGQSVLELPTDRQRPALPSYRGARHELQLPQALGRQLQALA 286
Cdd:COG4908    156 PPPLPELPIQYADYAAWQRAWLQSEALEKQLEYWRQQLAGAPPVLELPTDRPRPAVQTFRGATLSFTLPAELTEALKALA 235


                   ....*...
gi 2183974163  287 QREGTTLF 294
Cdd:COG4908    236 KAHGATVN 243

Acs

COG0365

Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase [Lipid transport and metabolism];

1571-2071

3.38e-73

Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase [Lipid transport and metabolism];

Pssm-ID: 440134 [Multi-domain] Cd Length: 565 Bit Score: 256.96 E-value: 3.38e-73

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1571 HRLIERQAAERPRATAVVY-----GERALDYGELNLRANRLAHRLIELGVGP-DVlVGLAAERSLEMIVGLLAILKAGGA 1644
Cdd:COG0365     12 YNCLDRHAEGRGDKVALIWegedgEERTLTYAELRREVNRFANALRALGVKKgDR-VAIYLPNIPEAVIAMLACARIGAV 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1645 YVPLDPRYPSDRLGYMIEDSGIRLLLTQ----------------RAARERLP-------LGEGLPCLLLDAEHEWAGYPE 1701
Cdd:COG0365     91 HSPVFPGFGAEALADRIEDAEAKVLITAdgglrggkvidlkekvDEALEELPslehvivVGRTGADVPMEGDLDWDELLA 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1702 SDPQSA----VGVDNLAYVIYTSGSTGKPKGTLLPHGNVLrLFDAT--RHWFGFSADD--------AWSLFHSYAfdfsv 1767
Cdd:COG0365    171 AASAEFepepTDADDPLFILYTSGTTGKPKGVVHTHGGYL-VHAATtaKYVLDLKPGDvfwctadiGWATGHSYI----- 244

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1768 weIFGALLHGGRLVIvpYE---TSRSPEDFLRLLCRERVTVLNQTPSAFKQLMQvacAGQEVPP----LALRHVVFGGEA 1840
Cdd:COG0365    245 --VYGPLLNGATVVL--YEgrpDFPDPGRLWELIEKYGVTVFFTAPTAIRALMK---AGDEPLKkydlSSLRLLGSAGEP 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1841 LEVQALRPWFERFGdrAPrLVNMYGITETTVHVtyrplsLADLDGGAASP--IGEPIPDLSWYLLDAGLNPVPRGCIGEL 1918
Cdd:COG0365    318 LNPEVWEWWYEAVG--VP-IVDGWGQTETGGIF------ISNLPGLPVKPgsMGKPVPGYDVAVVDEDGNPVPPGEEGEL 388

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1919 YVGGA--GLARGYLNRPElsctRFVADPFSTTGGrLYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQ 1996
Cdd:COG0365    389 VIKGPwpGMFRGYWNDPE----RYRETYFGRFPG-WYRTGDGARRDEDGYFWILGRSDDVINVSGHRIGTAEIESALVSH 463

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2183974163 1997 PGVAEAVV--LPHEGPGaTQLVGYVVTQAAPSDPAALRDTLRQALKASLPEHMVPAHLLFLERLPLTANGKLDRRAL 2071
Cdd:COG0365    464 PAVAEAAVvgVPDEIRG-QVVKAFVVLKPGVEPSDELAKELQAHVREELGPYAYPREIEFVDELPKTRSGKIMRRLL 539

C_PKS-NRPS

Condensation domain of hybrid polyketide synthetase/nonribosomal peptide synthetases (PKS ...

1114-1532

5.37e-73

Pssm-ID: 380471 [Multi-domain] Cd Length: 430 Bit Score: 251.80 E-value: 5.37e-73

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1114 LSFAQERQWFIWRLDPHSAAYNIPVALRLKGPLRRDALQGALDLLVQRHETLRTTFVEHDGAPRQ--VIHPTLPIAIEER 1191
Cdd:cd20483      4 MSTFQRRLWFLHNFLEDKTFLNLLLVCHIKGKPDVNLLQKALSELVRRHEVLRTAYFEGDDFGEQqvLDDPSFHLIVIDL 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1192 RPPVAGE-DLKGLVETEAHRPFDLQRGPLLRVLLLPLATDECVLVLTLHHIIADGWSMQVLVDELIRVYAALRHDQPPA- 1269
Cdd:cd20483     84 SEAADPEaALDQLVRNLRRQELDIEEGEVIRGWLVKLPDEEFALVLASHHIAWDRGSSKSIFEQFTALYDALRAGRDLAt 163

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1270 LAELPIQYADFAAWQRQWMDGGERERQLDYWVSRLGG--EQPLLeLP---SDRPrPQQQSHRGRRIGIpLPAELAEALRR 1344
Cdd:cd20483    164 VPPPPVQYIDFTLWHNALLQSPLVQPLLDFWKEKLEGipDASKL-LPfakAERP-PVKDYERSTVEAT-LDKELLARMKR 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1345 LAQAEQGTLFMLLLASFQALLHRYSGQNDIRVGVPIANRNREETEGLIGFFVNTQVLRAELDGQLPFRELLRQVRQAVVE 1424
Cdd:cd20483    241 ICAQHAVTPFMFLLAAFRAFLYRYTEDEDLTIGMVDGDRPHPDFDDLVGFFVNMLPIRCRMDCDMSFDDLLESTKTTCLE 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1425 AQGHQDLPFEQLVDALQPERSLSHAPLFQVMYNHQRddHRGSRFASLGELEVEDL-AWDVQTaQFDLTLDTYE-SSNGLL 1502
Cdd:cd20483    321 AYEHSAVPFDYIVDALDVPRSTSHFPIGQIAVNYQV--HGKFPEYDTGDFKFTDYdHYDIPT-ACDIALEAEEdPDGGLD 397

                          410       420       430
                   ....*....|....*....|....*....|
gi 2183974163 1503 AELTYATDLFDASSAERIAGHWLNLLRSIV 1532
Cdd:cd20483    398 LRLEFSTTLYDSADMERFLDNFVTFLTSVI 427

beta-lac_NRPS

Condensation domain of nonribosomal peptide synthetases (NRPSs) similar to Nocardia uniformis ...

2637-3052

7.75e-73

Condensation domain of nonribosomal peptide synthetases (NRPSs) similar to Nocardia uniformis NocB which exhibits an unusual cyclization to form beta-lactam rings in pro-nocardicin G synthesis; Nocardia uniformis NRPS NocB acts centrally in the biosynthesis of the nocardicin monocyclic beta-lactam antibiotics. Along with another NRPS NocA, it mediates an unusual cyclization to form beta-lactam rings in the synthesis of the beta-lactam-containing pentapeptide pro-nocardicin G. This small subfamily is related to DCL-type Condensation (C) domains, which catalyze condensation between a D-aminoacyl/peptidyl-PCP donor and a L-aminoacyl-PCP acceptor. NRPSs catalyze peptide bond formation within (usually) large multi-modular enzymatic complexes. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long (with various activities such as antibiotic, antifungal, antitumor and immunosuppression). There are various subtypes of C-domains such as the LCL-type which catalyzes peptide bond formation between two L-amino acids, the DCL-type which links an L-amino acid to the D-amino acid at the end of a growing peptide, starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and heterocyclization (Cyc) domains which catalyze both peptide bond formation and cyclization of Cys, Ser, or Thr residues. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the epimerization (E) domain, the ester-bond forming C-domain, dual E/C (epimerization and condensation) domains, and the X-domain. C-domains typically have a conserved HHxxxD motif at the active site; domains belonging to this subfamily have an HHHxxxD motif at the active site.

Pssm-ID: 380469 [Multi-domain] Cd Length: 422 Bit Score: 251.08 E-value: 7.75e-73

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2637 LYPLSPMQQGMLFHSLYQQNSGDYINQMRLD-VEGLDPQRFREAWQAALDAHEVLRSGFLWQgALEKPLQLVRKRVEVPF 2715
Cdd:cd19547      1 VYPLAPMQEGMLFRGLFWPDSDAYFNQNVLElVGGTDEDVLREAWRRVADRYEILRTGFTWR-DRAEPLQYVRDDLAPPW 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2716 SVHDWR----DRADLAEALDALAAGEAGLGfeLAEAPLLRLVLVRTGERRHHLIYTNHHILMDGWSNSQLLGEVLQRY-- 2789
Cdd:cd19547     80 ALLDWSgedpDRRAELLERLLADDRAAGLS--LADCPLYRLTLVRLGGGRHYLLWSHHHILLDGWCLSLIWGDVFRVYee 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2790 --RGETPSRSDGR-YRDYIAWLQRQDA--GRTEAFWKQRLQRLgEPTllvpAFAHGVRGAEGHADR-YRQLDVTTSQRLA 2863
Cdd:cd19547    158 laHGREPQLSPCRpYRDYVRWIRARTAqsEESERFWREYLRDL-TPS----PFSTAPADREGEFDTvVHEFPEQLTRLVN 232

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2864 EFAREQKVTLNTLVQAAWLILLQRFTGQDTVAFGATVSGRPAELRGIEEQIGLFINTLPVVASPCPEQPIGDWLQAVQGE 2943
Cdd:cd19547    233 EAARGYGVTTNAISQAAWSMLLALQTGARDVVHGLTIAGRPPELEGSEHMVGIFINTIPLRIRLDPDQTVTGLLETIHRD 312

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2944 NLALREFEHTPLYDIQRWAGQV---GEALFDNILVFENYPvsaalAEETPAD---MRIDALSNQEQTHYPLTLLVSAGET 3017
Cdd:cd19547    313 LATTAAHGHVPLAQIKSWASGErlsGGRVFDNLVAFENYP-----EDNLPGDdlsIQIIDLHAQEKTEYPIGLIVLPLQK 387

                          410       420       430
                   ....*....|....*....|....*....|....*
gi 2183974163 3018 LELHYSYSRQAFDEAAIECLAERLERLLLGMCENP 3052
Cdd:cd19547    388 LAFHFNYDTTHFTRAQVDRFIEVFRLLTEQLCRRP 422

AFD_class_I

cd04433

Adenylate forming domain, Class I, also known as the ANL superfamily; This family is known as ...

1713-2067

8.17e-73

Adenylate forming domain, Class I, also known as the ANL superfamily; This family is known as the ANL (acyl-CoA synthetases, the NRPS adenylation domains, and the Luciferase enzymes) superfamily. It includes acyl- and aryl-CoA ligases, as well as the adenylation domain of nonribosomal peptide synthetases and firefly luciferases.The adenylate-forming enzymes catalyze an ATP-dependent two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein. The active site of the domain is located at the interface of a large N-terminal subdomain and a smaller C-terminal subdomain.

Pssm-ID: 341228 [Multi-domain] Cd Length: 336 Bit Score: 247.97 E-value: 8.17e-73

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1713 LAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRHWFGFSADDAWSLFHSYAFDFSVWEIFGALLHGGRLVIVPyetSRSPE 1792
Cdd:cd04433      2 PALILYTSGTTGKPKGVVLSHRNLLAAAAALAASGGLTEGDVFLSTLPLFHIGGLFGLLGALLAGGTVVLLP---KFDPE 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1793 DFLRLLCRERVTVLNQTPSAFKQLMQVACAGQEVPPlALRHVVFGGEALEVQALRPWFERFGdraPRLVNMYGITETTVH 1872
Cdd:cd04433     79 AALELIEREKVTILLGVPTLLARLLKAPESAGYDLS-SLRALVSGGAPLPPELLERFEEAPG---IKLVNGYGLTETGGT 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1873 VTyrpLSLADLDGGAASPIGEPIPDLSWYLLDAGLNPVPRGCIGELYVGGAGLARGYLNRPELscTRFVadpfstTGGRL 1952
Cdd:cd04433    155 VA---TGPPDDDARKPGSVGRPVPGVEVRIVDPDGGELPPGEIGELVVRGPSVMKGYWNNPEA--TAAV------DEDGW 223

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1953 YRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVVLPHEGPGATQLVGYVVTQAAPSDPAAlr 2032
Cdd:cd04433    224 YRTGDLGRLDEDGYLYIVGRLKDMIKSGGENVYPAEVEAVLLGHPGVAEAAVVGVPDPEWGERVVAVVVLRPGADLDA-- 301

                          330       340       350
                   ....*....|....*....|....*....|....*
gi 2183974163 2033 DTLRQALKASLPEHMVPAHLLFLERLPLTANGKLD 2067
Cdd:cd04433    302 EELRAHVRERLAPYKVPRRVVFVDALPRTASGKID 336

X-Domain_NRPS

X-domain is a catalytically inactive Condensation-like domain shown to recruit oxygenases to ...

1114-1535

1.84e-72

Pssm-ID: 380468 [Multi-domain] Cd Length: 440 Bit Score: 250.86 E-value: 1.84e-72

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1114 LSFAQERQWFIWRLDPHSAAYNIPVALRLKGPLRRDALQGALDLLVQRHETLRTTFVEHDGAPRQVIHPTLPIAIEERRP 1193
Cdd:cd19546      7 ATAGQLRTWLLARLDEETRGRHLSVALRLRGRLDRDALEAALGDVAARHEILRTTFPGDGGDVHQRILDADAARPELPVV 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1194 PVAGEDLKGLVETEAHRPFDLQRGPLLRVLLLPLATDECVLVLTLHHIIADGWSMQVLVDELIRVYAALRHDQPPALAEL 1273
Cdd:cd19546     87 PATEEELPALLADRAAHLFDLTRETPWRCTLFALSDTEHVLLLVVHRIAADDESLDVLVRDLAAAYGARREGRAPERAPL 166

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1274 PIQYADFAAWQRQWMDgGERER------QLDYWVSRLGGEQPLLELPSDRPRPQQQSHRGRRIGIPLPAELAEALRRLAQ 1347
Cdd:cd19546    167 PLQFADYALWERELLA-GEDDRdsligdQIAYWRDALAGAPDELELPTDRPRPVLPSRRAGAVPLRLDAEVHARLMEAAE 245

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1348 AEQGTLFMLLLASFQALLHRYSGQNDIRVGVPIANRNRE-ETEGLIGFFVNTQVLRAELDGQLPFRELLRQVRQAVVEAQ 1426
Cdd:cd19546    246 SAGATMFTVVQAALAMLLTRLGAGTDVTVGTVLPRDDEEgDLEGMVGPFARPLALRTDLSGDPTFRELLGRVREAVREAR 325

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1427 GHQDLPFEQLVDALQPERSLSHAPLFQVMYNHQRDDHRGSRFASLGELEVEDLAWDVQTAQFDLTLDTYE------SSNG 1500
Cdd:cd19546    326 RHQDVPFERLAELLALPPSADRHPVFQVALDVRDDDNDPWDAPELPGLRTSPVPLGTEAMELDLSLALTErrnddgDPDG 405

                          410       420       430
                   ....*....|....*....|....*....|....*
gi 2183974163 1501 LLAELTYATDLFDASSAERIAGHWLNLLRSIVARP 1535
Cdd:cd19546    406 LDGSLRYAADLFDRATAAALARRLVRVLEQVAADP 440

FC-FACS_FadD_like

cd05936

Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; This ...

1570-2071

1.14e-69

Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; This subfamily of the AMP-forming adenylation family contains Escherichia coli FadD and similar prokaryotic fatty acid CoA synthetases. FadD was characterized as a long-chain fatty acid CoA synthetase. The gene fadD is regulated by the fatty acid regulatory protein FadR. Fatty acid CoA synthetase catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, followed by the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.

Pssm-ID: 341259 [Multi-domain] Cd Length: 468 Bit Score: 243.62 E-value: 1.14e-69

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1570 LHRLIERQAAERPRATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLD 1649
Cdd:cd05936      1 LADLLEEAARRFPDKTALIFMGRKLTYRELDALAEAFAAGLQNLGVQPGDRVALMLPNCPQFPIAYFGALKAGAVVVPLN 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1650 PRYPSDRLGYMIEDSGIRLLLTQRAARERLPLGEGLPcllldaehewaGYPESDPqsavgvDNLAYVIYTSGSTGKPKGT 1729
Cdd:cd05936     81 PLYTPRELEHILNDSGAKALIVAVSFTDLLAAGAPLG-----------ERVALTP------EDVAVLQYTSGTTGVPKGA 143

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1730 LLPHGNVLRLFDATRHWFGFS--ADD----AWSLFHSYAFDFSVweiFGALLHGGRLVIVPyetSRSPEDFLRLLCRERV 1803
Cdd:cd05936    144 MLTHRNLVANALQIKAWLEDLleGDDvvlaALPLFHVFGLTVAL---LLPLALGATIVLIP---RFRPIGVLKEIRKHRV 217

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1804 TVLNQTPSAFKQLMQVAcAGQEVPPLALRHVVFGGEALEVQALRPWFERFGDrapRLVNMYGITETTVHVTYRPLSLADL 1883
Cdd:cd05936    218 TIFPGVPTMYIALLNAP-EFKKRDFSSLRLCISGGAPLPVEVAERFEELTGV---PIVEGYGLTETSPVVAVNPLDGPRK 293

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1884 DGGaaspIGEPIPDLSWYLLDAGLNPVPRGCIGELYVGGAGLARGYLNRPELSCTRFVadpfsttGGRLyRTGDLARYRC 1963
Cdd:cd05936    294 PGS----IGIPLPGTEVKIVDDDGEELPPGEVGELWVRGPQVMKGYWNRPEETAEAFV-------DGWL-RTGDIGYMDE 361

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1964 DGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVV--LPHEGPGATqLVGYVVTQaapSDPAALRDTLRQALKA 2041
Cdd:cd05936    362 DGYFFIVDRKKDMIIVGGFNVYPREVEEVLYEHPAVAEAAVvgVPDPYSGEA-VKAFVVLK---EGASLTEEEIIAFCRE 437

                          490       500       510
                   ....*....|....*....|....*....|
gi 2183974163 2042 SLPEHMVPAHLLFLERLPLTANGKLDRRAL 2071
Cdd:cd05936    438 QLAGYKVPRQVEFRDELPKSAVGKILRREL 467

AFD_class_I

cd04433

Adenylate forming domain, Class I, also known as the ANL superfamily; This family is known as ...

656-1002

1.11e-66

Pssm-ID: 341228 [Multi-domain] Cd Length: 336 Bit Score: 230.25 E-value: 1.11e-66

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  656 LCYAIYTSGSTGQPKGVMVRHRALTNFVCSIARQPGMLARDRLLSVTTFSFDIFGLELYVPLARGASMLLASReqaQDPE 735
Cdd:cd04433      2 PALILYTSGTTGKPKGVVLSHRNLLAAAAALAASGGLTEGDVFLSTLPLFHIGGLFGLLGALLAGGTVVLLPK---FDPE 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  736 ALLDLVERQGVTVLQATPATWRMLCD---SERVDL--LRgcTLLCGGEALAEDLAAR-MRGLSASTWNLYGPTETTIWSA 809
Cdd:cd04433     79 AALELIEREKVTILLGVPTLLARLLKapeSAGYDLssLR--ALVSGGAPLPPELLERfEEAPGIKLVNGYGLTETGGTVA 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  810 RFRLGEEARPF--LGGPLENTALYILDSEMNPCPPGVAGELLIGGDGLARGYHRRPGLTAERFlpdpfaADGsrLYRTGD 887
Cdd:cd04433    157 TGPPDDDARKPgsVGRPVPGVEVRIVDPDGGELPPGEIGELVVRGPSVMKGYWNNPEATAAVD------EDG--WYRTGD 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  888 LARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQP-GVAGPTLVAYLVPTEAALVDAEsarqqE 966
Cdd:cd04433    229 LGRLDEDGYLYIVGRLKDMIKSGGENVYPAEVEAVLLGHPGVAEAAVVGVPdPEWGERVVAVVVLRPGADLDAE-----E 303

                          330       340       350
                   ....*....|....*....|....*....|....*.
gi 2183974163  967 LRSALKnsllAVLPDYMVPAHMLLLENLPLTPNGKI 1002
Cdd:cd04433    304 LRAHVR----ERLAPYKVPRRVVFVDALPRTASGKI 335

DCL_NRPS-like

DCL-type Condensation domains of nonribosomal peptide synthetases (NRPSs), such as terminal ...

2637-3035

5.53e-66

DCL-type Condensation domains of nonribosomal peptide synthetases (NRPSs), such as terminal fungal CT domains and Dual Epimerization/Condensation (E/C) domains; Condensation (C) domains of nonribosomal peptide synthetases (NRPSs) catalyze peptide bond formation within (usually) large multi-modular enzymatic complexes. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long (with various activities such as antibiotic, antifungal, antitumor and immunosuppression). There are various subtypes of C-domains such as the LCL-type which catalyzes peptide bond formation between two L-amino acids, the DCL-type [D-specific for the peptidyl donor and L-specific for the aminoacyl acceptor ((D)C(L))], which links an L-amino acid to the D-amino acid at the end of a growing peptide, starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and heterocyclization (Cyc) domains which catalyze both peptide bond formation and cyclization of Cys, Ser, or Thr residues. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the epimerization (E) domain, the ester-bond forming C-domain, dual E/C (epimerization and condensation) domains, and the X-domain. C-domains typically have a conserved HHxxxD motif at the active site; mutations in this motif can abolish or diminish condensation activity.

Pssm-ID: 380459 [Multi-domain] Cd Length: 419 Bit Score: 231.18 E-value: 5.53e-66

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2637 LYPLSPMQQGMLFHSLYQQNSGDYINQMRLDVEG-LDPQRFREAWQAALDAHEVLRSGFLWQGaLEKPLQLVRKRVEVPF 2715
Cdd:cd19536      1 MYPLSSLQEGMLFHSLLNPGGSVYLHNYTYTVGRrLNLDLLLEALQVLIDRHDILRTSFIEDG-LGQPVQVVHRQAQVPV 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2716 SVHDWRDRADLAEALDALAAGEAGLGFELAEAPLLRLVLVRTGERRHH-LIYTNHHILMDGWSNSQLLGEVLQRYRGET- 2793
Cdd:cd19536     80 TELDLTPLEEQLDPLRAYKEETKIRRFDLGRAPLVRAALVRKDERERFlLVISDHHSILDGWSLYLLVKEILAVYNQLLe 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2794 ------PSRSDgrYRDYIAWLQRQ-DAGRTEAFWKQRLQrlgEPTLLVPAFAHGVRGAEGHADRYRQLDVTTSQRLAEFA 2866
Cdd:cd19536    160 ykplslPPAQP--YRDFVAHERASiQQAASERYWREYLA---GATLATLPALSEAVGGGPEQDSELLVSVPLPVRSRSLA 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2867 REQKVTLNTLVQAAWLILLQRFTGQDTVAFGATVSGRPAELRGIEEQIGLFINTLPVVASpCPEQPIGDWLQAVQGENLA 2946
Cdd:cd19536    235 KRSGIPLSTLLLAAWALVLSRHSGSDDVVFGTVVHGRSEETTGAERLLGLFLNTLPLRVT-LSEETVEDLLKRAQEQELE 313

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2947 LREFEHTPLYDIQRWAGqvGEALFDNILVFENYPVSAALAEET-PADMRIDALSNQEQTHYPLTLLVS-AGETLELHYSY 3024
Cdd:cd19536    314 SLSHEQVPLADIQRCSE--GEPLFDSIVNFRHFDLDFGLPEWGsDEGMRRGLLFSEFKSNYDVNLSVLpKQDRLELKLAY 391

                          410
                   ....*....|.
gi 2183974163 3025 SRQAFDEAAIE 3035
Cdd:cd19536    392 NSQVLDEEQAQ 402

FACL_FadD13-like

cd17631

fatty acyl-CoA synthetase, including FadD13; This family contains fatty acyl-CoA synthetases, ...

520-1002

1.68e-65

fatty acyl-CoA synthetase, including FadD13; This family contains fatty acyl-CoA synthetases, including Mycobacterium tuberculosis acid-induced operon MymA encoding the fatty acyl-CoA synthetase FadD13 which is essential for virulence and intracellular growth of the pathogen. The fatty acyl-CoA synthetase activates lipids before entering into the metabolic pathways and is also involved in transmembrane lipid transport. However, unlike soluble fatty acyl-CoA synthetases, but like the mammalian integral-membrane very-long-chain acyl-CoA synthetases, FadD13 accepts lipid substrates up to the maximum length of C26, and this is facilitated by an extensive hydrophobic tunnel from the active site to a positively charged patch. Also included is feruloyl-CoA synthetase (Fcs) in Rhodococcus strains where it is involved in biotechnological vanillin production from eugenol and ferulic acid via a non-beta-oxidative pathway.

Pssm-ID: 341286 [Multi-domain] Cd Length: 435 Bit Score: 230.19 E-value: 1.68e-65

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  520 AGLTPDAPALLFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRL 599
Cdd:cd17631      5 ARRHPDRTALVFGGRSLTYAELDERVNRLAHALRALGVAKGDRVAVLSKNSPEFLELLFAAARLGAVFVPLNFRLTPPEV 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  600 QYMIDDSGLRLLLsqqsvlarlpqsdglqslllddlerlvhgypaenpdlpeapDSLCYAIYTSGSTGQPKGVMVRHRAL 679
Cdd:cd17631     85 AYILADSGAKVLF-----------------------------------------DDLALLMYTSGTTGRPKGAMLTHRNL 123

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  680 TNFVCSIARQPGMLARDRLLSVTTFsFDIFGLELYVP--LARGASMLLASReqaQDPEALLDLVERQGVTVLQATPATWR 757
Cdd:cd17631    124 LWNAVNALAALDLGPDDVLLVVAPL-FHIGGLGVFTLptLLRGGTVVILRK---FDPETVLDLIERHRVTSFFLVPTMIQ 199

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  758 MLCDSER---VDLLRGCTLLCGGEALAEDLAARMRGLSASTWNLYGPTETTIwSARFRLGEEARPFLGG---PLENTALY 831
Cdd:cd17631    200 ALLQHPRfatTDLSSLRAVIYGGAPMPERLLRALQARGVKFVQGYGMTETSP-GVTFLSPEDHRRKLGSagrPVFFVEVR 278

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  832 ILDSEMNPCPPGVAGELLIGGDGLARGYHRRPGLTAERFlpdpfaADGsrLYRTGDLARYRADGVIEYLGRIDHQVKIRG 911
Cdd:cd17631    279 IVDPDGREVPPGEVGEIVVRGPHVMAGYWNRPEATAAAF------RDG--WFHTGDLGRLDEDGYLYIVDRKKDMIISGG 350

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  912 FRIELGEIETRLLEQDSVREAVVVAQPGVA-GPTLVAYLVPTEAALVDAEsarqqelrsALKNSLLAVLPDYMVPAHMLL 990
Cdd:cd17631    351 ENVYPAEVEDVLYEHPAVAEVAVIGVPDEKwGEAVVAVVVPRPGAELDED---------ELIAHCRERLARYKIPKSVEF 421

                          490
                   ....*....|..
gi 2183974163  991 LENLPLTPNGKI 1002
Cdd:cd17631    422 VDALPRNATGKI 433

ligase_PEP_1

TIGR03098

acyl-CoA ligase (AMP-forming), exosortase A-associated; This group of proteins contains an ...

1570-2073

1.04e-64

acyl-CoA ligase (AMP-forming), exosortase A-associated; This group of proteins contains an AMP-binding domain (pfam00501) associated with acyl CoA-ligases. These proteins are generally found in genomes containing the exosortase/PEP-CTERM protein expoert system, specifically the type 1 variant of this system described by the Genome Property GenProp0652. When found in this context they are invariably present next to a decarboxylase enzyme. A number of sequences from Burkholderia species also hit this model, but the genomic context is obviously different. The hypothesis of a constant substrate for this family is only strong where the exosortase context is present.

Pssm-ID: 211788 [Multi-domain] Cd Length: 517 Bit Score: 230.82 E-value: 1.04e-64

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1570 LHRLIERQAAERPRATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLD 1649
Cdd:TIGR03098    2 LHHLLEDAAARLPDATALVHHDRTLTYAALSERVLALASGLRGLGLARGERVAIYLDKRLETVTAMFGAALAGGVFVPIN 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1650 PRYPSDRLGYMIEDSGIRLLLTqraARERL-----------------------PLGEGLPCLLLDAEHEWAGYPESDPQS 1706
Cdd:TIGR03098   82 PLLKAEQVAHILADCNVRLLVT---SSERLdllhpalpgchdlrtliivgdpaHASEGHPGEEPASWPKLLALGDADPPH 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1707 AVGVDNLAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRHWFGFSADDAWSLFHSYAFDFSVWEIFGALLHGGRLVIVPYE 1786
Cdd:TIGR03098  159 PVIDSDMAAILYTSGSTGRPKGVVLSHRNLVAGAQSVATYLENRPDDRLLAVLPLSFDYGFNQLTTAFYVGATVVLHDYL 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1787 TsrsPEDFLRLLCRERVTVLNQTPSAFKQLMQVAcagqeVPPLA---LRHVVFGGEALEVQALRPWFERFGDRAPRLvnM 1863
Cdd:TIGR03098  239 L---PRDVLKALEKHGITGLAAVPPLWAQLAQLD-----WPESAapsLRYLTNSGGAMPRATLSRLRSFLPNARLFL--M 308

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1864 YGITEtTVHVTYRPLSLADLDGGAaspIGEPIPDLSWYLLDAGLNPVPRGCIGELYVGGAGLARGYLNRPELSCTRFVAD 1943
Cdd:TIGR03098  309 YGLTE-AFRSTYLPPEEVDRRPDS---IGKAIPNAEVLVLREDGSECAPGEEGELVHRGALVAMGYWNDPEKTAERFRPL 384

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1944 P----FSTTGGRLYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVVLPHEGPGATQLVGYV 2019
Cdd:TIGR03098  385 PpfpgELHLPELAVWSGDTVRRDEEGFLYFVGRRDEMIKTSGYRVSPTEVEEVAYATGLVAEAVAFGVPDPTLGQAIVLV 464

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2183974163 2020 VTqaAPSDPAALRDTLRQALKASLPEHMVPAHLLFLERLPLTANGKLDRRALPA 2073
Cdd:TIGR03098  465 VT--PPGGEELDRAALLAECRARLPNYMVPALIHVRQALPRNANGKIDRKALAK 516

DCL_NRPS

DCL-type Condensation domain of nonribosomal peptide synthetases (NRPSs), which catalyzes the ...

49-477

3.65e-64

Pssm-ID: 380465 [Multi-domain] Cd Length: 423 Bit Score: 225.93 E-value: 3.65e-64

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163   49 PLSYAQERQWFLWQMDPQSAAYNIPSALRLRGELDVEALSASLGAIVERHQSLRTVFVEdEQLDGFRQQVLASVDVPVPV 128
Cdd:cd19543      3 PLSPMQEGMLFHSLLDPGSGAYVEQMVITLEGPLDPDRFRAAWQAVVDRHPILRTSFVW-EGLGEPLQVVLKDRKLPWRE 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  129 T-LAGDDDAQ--AQIRAFVESETQQPFDLRNGPLLRARLLRLAADDHVLTLTIHHVAADGWSMRVLVEELIALYGARRQG 205
Cdd:cd19543     82 LdLSHLSEAEqeAELEALAEEDRERGFDLARAPLMRLTLIRLGDDRYRLVWSFHHILLDGWSLPILLKELFAIYAALGEG 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  206 IEATLPDLPiQYADYAiwqrHWLEAGERERQLEYWMARLGGGQSVLELPTDRQRPALPSYRGARHELQLPQALGRQLQAL 285
Cdd:cd19543    162 QPPSLPPVR-PYRDYI----AWLQRQDKEAAEAYWREYLAGFEEPTPLPKELPADADGSYEPGEVSFELSAELTARLQEL 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  286 AQREGTTLFMLLLASFQALLHRYSGQDEIRVGVPVANRNR--VETERLIGFFVNTQVLRADLDAQMPFLDLLQQTRVAAL 363
Cdd:cd19543    237 ARQHGVTLNTVVQGAWALLLSRYSGRDDVVFGTTVSGRPAelPGIETMVGLFINTLPVRVRLDPDQTVLELLKDLQAQQL 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  364 GAQSHQDLPfeqLVEaLQpERSLSHSPLFQAMYNHQN--LGSAGRQSLAAQlpGLSVEDLSwGAHSAQFDLTLDTYESEQ 441
Cdd:cd19543    317 ELREHEYVP---LYE-IQ-AWSEGKQALFDHLLVFENypVDESLEEEQDED--GLRITDVS-AEEQTNYPLTVVAIPGEE 388

                          410       420       430
                   ....*....|....*....|....*....|....*.
gi 2183974163  442 gVHAEFTYATDLFEAATVERLARHWRNLLEAVVAEP 477
Cdd:cd19543    389 -LTIKLSYDAEVFDEATIERLLGHLRRVLEQVAANP 423

FC-FACS_FadD_like

cd05936

Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; This ...

514-1007

3.91e-64

Pssm-ID: 341259 [Multi-domain] Cd Length: 468 Bit Score: 227.45 E-value: 3.91e-64

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  514 RLFEAQAGLTPDAPALLFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQ 593
Cdd:cd05936      3 DLLEEAARRFPDKTALIFMGRKLTYRELDALAEAFAAGLQNLGVQPGDRVALMLPNCPQFPIAYFGALKAGAVVVPLNPL 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  594 YPADRLQYMIDDSGLRLLLSqqsvlarlpqsdglqsllLDDLERLVHGYPAENPDLPEAPDSLCYAIYTSGSTGQPKGVM 673
Cdd:cd05936     83 YTPRELEHILNDSGAKALIV------------------AVSFTDLLAAGAPLGERVALTPEDVAVLQYTSGTTGVPKGAM 144

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  674 VRHRALTNFVCSIAR--QPGMLARDRLLSVTTFsFDIFGLE--LYVPLARGASMLLASReqaQDPEALLDLVERQGVTVL 749
Cdd:cd05936    145 LTHRNLVANALQIKAwlEDLLEGDDVVLAALPL-FHVFGLTvaLLLPLALGATIVLIPR---FRPIGVLKEIRKHRVTIF 220

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  750 QATPATWRMLC---DSERVDL--LRGCtlLCGGEALAEDLAARMRGLSAStwNL---YGPTETTIWSARFRLGEEARP-F 820
Cdd:cd05936    221 PGVPTMYIALLnapEFKKRDFssLRLC--ISGGAPLPVEVAERFEELTGV--PIvegYGLTETSPVVAVNPLDGPRKPgS 296

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  821 LGGPLENTALYILDSEMNPCPPGVAGELLIGGDGLARGYHRRPGLTAERFLpdpfaaDGsrLYRTGDLARYRADGVIEYL 900
Cdd:cd05936    297 IGIPLPGTEVKIVDDDGEELPPGEVGELWVRGPQVMKGYWNRPEETAEAFV------DG--WLRTGDIGYMDEDGYFFIV 368

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  901 GRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQP-GVAGPTLVAYLVPTEAALVDAEsarqqELRSALKnsllAVL 979
Cdd:cd05936    369 DRKKDMIIVGGFNVYPREVEEVLYEHPAVAEAAVVGVPdPYSGEAVKAFVVLKEGASLTEE-----EIIAFCR----EQL 439

                          490       500
                   ....*....|....*....|....*...
gi 2183974163  980 PDYMVPAHMLLLENLPLTPNGKINRKAL 1007
Cdd:cd05936    440 AGYKVPRQVEFRDELPKSAVGKILRREL 467

DCL_NRPS

DCL-type Condensation domain of nonribosomal peptide synthetases (NRPSs), which catalyzes the ...

1127-1535

5.00e-64

Pssm-ID: 380465 [Multi-domain] Cd Length: 423 Bit Score: 225.55 E-value: 5.00e-64

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1127 LDPHSAAYNIPVALRLKGPLRRDALQGALDLLVQRHETLRTTFV-EHDGAPRQVIHptlpiaiEERRPPVAGEDLKGLVE 1205
Cdd:cd19543     17 LDPGSGAYVEQMVITLEGPLDPDRFRAAWQAVVDRHPILRTSFVwEGLGEPLQVVL-------KDRKLPWRELDLSHLSE 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1206 TEA------------HRPFDLQRGPLLRVLLLPLATDECVLVLTLHHIIADGWSMQVLVDELIRVYAALRHDQPPALAEL 1273
Cdd:cd19543     90 AEQeaelealaeedrERGFDLARAPLMRLTLIRLGDDRYRLVWSFHHILLDGWSLPILLKELFAIYAALGEGQPPSLPPV 169

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1274 PiQYADFAAW-QRQwmdggERERQLDYWVSRLGGEQPLLELPSDRPRPQQQSHRGRRIGIPLPAELAEALRRLAQAEQGT 1352
Cdd:cd19543    170 R-PYRDYIAWlQRQ-----DKEAAEAYWREYLAGFEEPTPLPKELPADADGSYEPGEVSFELSAELTARLQELARQHGVT 243

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1353 LFMLLLASFQALLHRYSGQNDIRVGVPIANRNRE--ETEGLIGFFVNTQVLRAELDGQLPFRELLRQVRQAVVEAQGHQD 1430
Cdd:cd19543    244 LNTVVQGAWALLLSRYSGRDDVVFGTTVSGRPAElpGIETMVGLFINTLPVRVRLDPDQTVLELLKDLQAQQLELREHEY 323

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1431 LPfeqLVDaLQpERSLSHAPLFQ---VMYNHQRDDHRGSRFASLGeLEVEDLAWDVQTaQFDLTLDTYEsSNGLLAELTY 1507
Cdd:cd19543    324 VP---LYE-IQ-AWSEGKQALFDhllVFENYPVDESLEEEQDEDG-LRITDVSAEEQT-NYPLTVVAIP-GEELTIKLSY 395

                          410       420
                   ....*....|....*....|....*...
gi 2183974163 1508 ATDLFDASSAERIAGHWLNLLRSIVARP 1535
Cdd:cd19543    396 DAEVFDEATIERLLGHLRRVLEQVAANP 423

A_NRPS_acs4

cd17654

acyl-CoA synthetase family member 4; This family of the adenylation (A) domain of nonribosomal ...

524-1007

1.40e-63

acyl-CoA synthetase family member 4; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) contains acyl-CoA synthethase family member 4, also known as 2-aminoadipic 6-semialdehyde dehydrogenase or aminoadipate-semialdehyde dehydrogenase, most of which are uncharacterized. Acyl-CoA synthetase catalyzes the initial reaction in fatty acid metabolism, by forming a thioester with CoA. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.

Pssm-ID: 341309 [Multi-domain] Cd Length: 449 Bit Score: 225.43 E-value: 1.40e-63

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  524 PDAPALLFGEER----LSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRL 599
Cdd:cd17654      1 PDRPALIIDQTTsdttVSYADLAEKISNLSNFLRKKFQTEERAIGLRCDRGTESPVAILAILFLGAAYAPIDPASPEQRS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  600 QYMIDDSGLRLLLSQQsvlarlpqsdglqsllLDDLERLVHGYPAENPDLPeAPDSLCYAIYTSGSTGQPKGVMVRHRAL 679
Cdd:cd17654     81 LTVMKKCHVSYLLQNK----------------ELDNAPLSFTPEHRHFNIR-TDECLAYVIHTSGTTGTPKIVAVPHKCI 143

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  680 TNFVCSiARQPGMLARDRLLSVTTF-SFDIFGLELYVPLARGASMLLASREQAQDPEALLD-LVERQGVTVLQATPATWR 757
Cdd:cd17654    144 LPNIQH-FRSLFNITSEDILFLTSPlTFDPSVVEIFLSLSSGATLLIVPTSVKVLPSKLADiLFKRHRITVLQATPTLFR 222

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  758 MLCDSERVDL-------LRgcTLLCGGEA---LAEDLAARMRGLSASTWNLYGPTETTIWSARFRLGEEARPF-LGGPLE 826
Cdd:cd17654    223 RFGSQSIKSTvlsatssLR--VLALGGEPfpsLVILSSWRGKGNRTRIFNIYGITEVSCWALAYKVPEEDSPVqLGSPLL 300

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  827 NTALYILDSEMNPcppgVAGELLIGgdGLARGYhrrpgltaerFLPDPFAADGSRLYRTGDLARyRADGVIEYLGRIDHQ 906
Cdd:cd17654    301 GTVIEVRDQNGSE----GTGQVFLG--GLNRVC----------ILDDEVTVPKGTMRATGDFVT-VKDGELFFLGRKDSQ 363

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  907 VKIRGFRIELGEIETRLLEQDSVrEAVVVA----QpgvagpTLVAYLVPTEAalvdaeSAR-QQELRSALKNSllAVLPD 981
Cdd:cd17654    364 IKRRGKRINLDLIQQVIESCLGV-ESCAVTlsdqQ------RLIAFIVGESS------SSRiHKELQLTLLSS--HAIPD 428

                          490       500
                   ....*....|....*....|....*.
gi 2183974163  982 YMVpahmlLLENLPLTPNGKINRKAL 1007
Cdd:cd17654    429 TFV-----QIDKLPLTSHGKVDKSEL 449

ligase_PEP_1

TIGR03098

acyl-CoA ligase (AMP-forming), exosortase A-associated; This group of proteins contains an ...

511-1007

1.16e-62

Pssm-ID: 211788 [Multi-domain] Cd Length: 517 Bit Score: 224.66 E-value: 1.16e-62

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  511 GVHRLFEAQAGLTPDAPALLFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPL 590
Cdd:TIGR03098    1 LLHHLLEDAAARLPDATALVHHDRTLTYAALSERVLALASGLRGLGLARGERVAIYLDKRLETVTAMFGAALAGGVFVPI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  591 DPQYPADRLQYMIDDSGLRLLLSQQSVLARL----PQSDGLQSLLL-DDLERLVHGYPAEN--------------PDLPE 651
Cdd:TIGR03098   81 NPLLKAEQVAHILADCNVRLLVTSSERLDLLhpalPGCHDLRTLIIvGDPAHASEGHPGEEpaswpkllalgdadPPHPV 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  652 APDSLCYAIYTSGSTGQPKGVMVRHRALTNFVCSIARQPGMLARDRLLSVTTFSFDiFGL-ELYVPLARGASMLLASREQ 730
Cdd:TIGR03098  161 IDSDMAAILYTSGSTGRPKGVVLSHRNLVAGAQSVATYLENRPDDRLLAVLPLSFD-YGFnQLTTAFYVGATVVLHDYLL 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  731 AQDpeaLLDLVERQGVTVLQATPATWRMLCD----SERVDLLRgcTLLCGGEALAEDLAARMRGL--SASTWNLYGPTET 804
Cdd:TIGR03098  240 PRD---VLKALEKHGITGLAAVPPLWAQLAQldwpESAAPSLR--YLTNSGGAMPRATLSRLRSFlpNARLFLMYGLTEA 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  805 tiWSARFRLGEEA--RP-FLGGPLENTALYILDSEMNPCPPGVAGELLIGGDGLARGYHRRPGLTAERFLPDPFAADGSR 881
Cdd:TIGR03098  315 --FRSTYLPPEEVdrRPdSIGKAIPNAEVLVLREDGSECAPGEEGELVHRGALVAMGYWNDPEKTAERFRPLPPFPGELH 392

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  882 LYRT----GDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVaqpGVAGPTLVAYLVPTEAALV 957
Cdd:TIGR03098  393 LPELavwsGDTVRRDEEGFLYFVGRRDEMIKTSGYRVSPTEVEEVAYATGLVAEAVAF---GVPDPTLGQAIVLVVTPPG 469

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|
gi 2183974163  958 DAESARqQELRSALKnsllAVLPDYMVPAHMLLLENLPLTPNGKINRKAL 1007
Cdd:TIGR03098  470 GEELDR-AALLAECR----ARLPNYMVPALIHVRQALPRNANGKIDRKAL 514

FACL_FadD13-like

cd17631

fatty acyl-CoA synthetase, including FadD13; This family contains fatty acyl-CoA synthetases, ...

1574-2068

2.58e-62

Pssm-ID: 341286 [Multi-domain] Cd Length: 435 Bit Score: 220.94 E-value: 2.58e-62

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1574 IERQAAERPRATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYP 1653
Cdd:cd17631      1 LRRRARRHPDRTALVFGGRSLTYAELDERVNRLAHALRALGVAKGDRVAVLSKNSPEFLELLFAAARLGAVFVPLNFRLT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1654 SDRLGYMIEDSGIRLLLtqraarerlplgeglpcllldaehewagypesdpqsavgvDNLAYVIYTSGSTGKPKGTLLPH 1733
Cdd:cd17631     81 PPEVAYILADSGAKVLF----------------------------------------DDLALLMYTSGTTGRPKGAMLTH 120

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1734 GNVLRLFDATRHWFGFSADD----AWSLFHSYAFDFSVweiFGALLHGGRLVIVPyetSRSPEDFLRLLCRERVTVLNQT 1809
Cdd:cd17631    121 RNLLWNAVNALAALDLGPDDvllvVAPLFHIGGLGVFT---LPTLLRGGTVVILR---KFDPETVLDLIERHRVTSFFLV 194

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1810 PSAFKQLMQVACAgQEVPPLALRHVVFGGEALEVQALRPWFErfgdRAPRLVNMYGITETTVHVTYrpLSLADLDGGAAS 1889
Cdd:cd17631    195 PTMIQALLQHPRF-ATTDLSSLRAVIYGGAPMPERLLRALQA----RGVKFVQGYGMTETSPGVTF--LSPEDHRRKLGS 267

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1890 pIGEPIPDLSWYLLDAGLNPVPRGCIGELYVGGAGLARGYLNRPELscTRfvadpfSTTGGRLYRTGDLARYRCDGVVEY 1969
Cdd:cd17631    268 -AGRPVFFVEVRIVDPDGREVPPGEVGEIVVRGPHVMAGYWNRPEA--TA------AAFRDGWFHTGDLGRLDEDGYLYI 338

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1970 VGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVV--LPHEGPGATQLVGYVVTQAAPSDPAALRDTLRQAlkasLPEHM 2047
Cdd:cd17631    339 VDRKKDMIISGGENVYPAEVEDVLYEHPAVAEVAVigVPDEKWGEAVVAVVVPRPGAELDEDELIAHCRER----LARYK 414

                          490       500
                   ....*....|....*....|.
gi 2183974163 2048 VPAHLLFLERLPLTANGKLDR 2068
Cdd:cd17631    415 IPKSVEFVDALPRNATGKILK 435

Acs

COG0365

Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase [Lipid transport and metabolism];

513-1020

4.25e-62

Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase [Lipid transport and metabolism];

Pssm-ID: 440134 [Multi-domain] Cd Length: 565 Bit Score: 224.61 E-value: 4.25e-62

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  513 HRLFEAQAGLTPDAPALLF----GEER-LSYAELNALANRLAWRLREEGVG-SDVlVGIALERGVPMVVALLAVLKAGGA 586
Cdd:COG0365     12 YNCLDRHAEGRGDKVALIWegedGEERtLTYAELRREVNRFANALRALGVKkGDR-VAIYLPNIPEAVIAMLACARIGAV 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  587 YVPLDPQYPADRLQYMIDDSGLRLLLSQQSVLAR-------------LPQSDGLQSLLL-------------DDLERLVH 640
Cdd:COG0365     91 HSPVFPGFGAEALADRIEDAEAKVLITADGGLRGgkvidlkekvdeaLEELPSLEHVIVvgrtgadvpmegdLDWDELLA 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  641 GYPAENPDLPEAPDSLCYAIYTSGSTGQPKGVMVRHR-----ALTNFVCSIARQPGmlarDRLLSVTTFSFdIFGL--EL 713
Cdd:COG0365    171 AASAEFEPEPTDADDPLFILYTSGTTGKPKGVVHTHGgylvhAATTAKYVLDLKPG----DVFWCTADIGW-ATGHsyIV 245

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  714 YVPLARGASMLLA-SREQAQDPEALLDLVERQGVTVLQATPATWRML-----CDSERVDL--LRgcTLLCGGEALAEDLA 785
Cdd:COG0365    246 YGPLLNGATVVLYeGRPDFPDPGRLWELIEKYGVTVFFTAPTAIRALmkagdEPLKKYDLssLR--LLGSAGEPLNPEVW 323

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  786 ARMR---GLS-ASTWnlyGPTETT-IWSArFRLGEEARP-FLGGPLENTALYILDSEMNPCPPGVAGELLIGGD--GLAR 857
Cdd:COG0365    324 EWWYeavGVPiVDGW---GQTETGgIFIS-NLPGLPVKPgSMGKPVPGYDVAVVDEDGNPVPPGEEGELVIKGPwpGMFR 399

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  858 GYHRRPGLTAERFLpDPFaaDGsrLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQ 937
Cdd:COG0365    400 GYWNDPERYRETYF-GRF--PG--WYRTGDGARRDEDGYFWILGRSDDVINVSGHRIGTAEIESALVSHPAVAEAAVVGV 474

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  938 P-GVAGPTLVAYLVPTEAALVDAesarqqELRSALKNSLLAVLPDYMVPAHMLLLENLPLTPNGKINRKAL-------PL 1009
Cdd:COG0365    475 PdEIRGQVVKAFVVLKPGVEPSD------ELAKELQAHVREELGPYAYPREIEFVDELPKTRSGKIMRRLLrkiaegrPL 548

                          570
                   ....*....|.
gi 2183974163 1010 PDASAVRDAHV 1020
Cdd:COG0365    549 GDTSTLEDPEA 559

CT_NRPS-like

Terminal Condensation (CT)-like domains of nonribosomal peptide synthetases (NRPSs); Unlike ...

2638-3036

4.47e-62

Terminal Condensation (CT)-like domains of nonribosomal peptide synthetases (NRPSs); Unlike bacterial NRPS, which typically have specialized terminal thioesterase (TE) domains to cyclize peptide products, many fungal NRPSs employ a terminal condensation-like (CT) domain to produce macrocyclic peptidyl products (e.g. cyclosporine and echinocandin). Domains in this subfamily (which includes both terminal and non-terminal domains) typically have a non-canonical conserved [SN]HxxxDx(14)Y motif at their active site compared to the standard Condensation (C) domain active site motif (HHxxxD). C-domains of NRPSs catalyze peptide bond formation within (usually) large multi-modular enzymatic complexes. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long (with various activities such as antibiotic, antifungal, antitumor and immunosuppression). There are various subtypes of C-domains such as the LCL-type which catalyzes peptide bond formation between two L-amino acids, the DCL-type which links an L-amino acid to the D-amino acid at the end of a growing peptide, starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and heterocyclization (Cyc) domains which catalyze both peptide bond formation and cyclization of Cys, Ser, or Thr residues. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the epimerization (E) domain, the ester-bond forming C-domain, dual E/C (epimerization and condensation) domains, and the X-domain.

Pssm-ID: 380464 [Multi-domain] Cd Length: 401 Bit Score: 219.10 E-value: 4.47e-62

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2638 YPLSPMQQGMLFHSLyqQNSGDYINQMRLDVEG-LDPQRFREAWQAALDAHEVLRSGFLWQGALEKPLQLVRKRVEVPFS 2716
Cdd:cd19542      2 YPCTPMQEGMLLSQL--RSPGLYFNHFVFDLDSsVDVERLRNAWRQLVQRHDILRTVFVESSAEGTFLQVVLKSLDPPIE 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2717 VHDWRDRADLAEALDALAAGEaglgfeLAEAPLLRLVLVRTGERRHHLIYTNHHILMDGWSNSQLLGEVLQRYRGETPSR 2796
Cdd:cd19542     80 EVETDEDSLDALTRDLLDDPT------LFGQPPHRLTLLETSSGEVYLVLRISHALYDGVSLPIILRDLAAAYNGQLLPP 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2797 SdGRYRDYIAWLQRQDAGRTEAFWKQRLQrlGEPTLLVPAfahgvrgAEGHADRYRQLDVT--TSQRLAEFAREQKVTLN 2874
Cdd:cd19542    154 A-PPFSDYISYLQSQSQEESLQYWRKYLQ--GASPCAFPS-------LSPKRPAERSLSSTrrSLAKLEAFCASLGVTLA 223

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2875 TLVQAAWLILLQRFTGQDTVAFGATVSGRPAELRGIEEQIGLFINTLPVVASPCPEQPIGDWLQAVQGENLALREFEHTP 2954
Cdd:cd19542    224 SLFQAAWALVLARYTGSRDVVFGYVVSGRDLPVPGIDDIVGPCINTLPVRVKLDPDWTVLDLLRQLQQQYLRSLPHQHLS 303

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2955 LYDIQRWAGQ-VGEALFDNILVFENYPvsAALAEETPADMRIDALSNQEQTHYPLTLLV-SAGETLELHYSYSRQAFDEA 3032
Cdd:cd19542    304 LREIQRALGLwPSGTLFNTLVSYQNFE--ASPESELSGSSVFELSAAEDPTEYPVAVEVePSGDSLKVSLAYSTSVLSEE 381


                   ....
gi 2183974163 3033 AIEC 3036
Cdd:cd19542    382 QAEE 385

PRK07656

long-chain-fatty-acid--CoA ligase; Validated

1573-2071

4.75e-60

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 236072 [Multi-domain] Cd Length: 513 Bit Score: 217.08 E-value: 4.75e-60

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1573 LIERQAAERPRATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRY 1652
Cdd:PRK07656    10 LLARAARRFGDKEAYVFGDQRLTYAELNARVRRAAAALAALGIGKGDRVAIWAPNSPHWVIAALGALKAGAVVVPLNTRY 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1653 PSDRLGYMIEDSGIRLLLTQ-------RAARERLPLGE-------GLPCLLLDAEHEWAGY--PESDPQSAVGV--DNLA 1714
Cdd:PRK07656    90 TADEAAYILARGDAKALFVLglflgvdYSATTRLPALEhvvicetEEDDPHTEKMKTFTDFlaAGDPAERAPEVdpDDVA 169

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1715 YVIYTSGSTGKPKGTLLPHGNVLRLFDATRHWFGFSADD----AWSLFHsyAFDFSVwEIFGALLHGGRLVIVPyetSRS 1790
Cdd:PRK07656   170 DILFTSGTTGRPKGAMLTHRQLLSNAADWAEYLGLTEGDrylaANPFFH--VFGYKA-GVNAPLMRGATILPLP---VFD 243

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1791 PEDFLRLLCRERVTVLNQTPSAFKQLMQVacAGQEVPPLA-LRHVVFGGEALEVQALRPWFERFGdrAPRLVNMYGITET 1869
Cdd:PRK07656   244 PDEVFRLIETERITVLPGPPTMYNSLLQH--PDRSAEDLSsLRLAVTGAASMPVALLERFESELG--VDIVLTGYGLSEA 319

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1870 TVHVTYRPlsladLDGGA---ASPIGEPIPDLSWYLLDAGLNPVPRGCIGELYVGGAGLARGYLNRPELSCTRFVADpfs 1946
Cdd:PRK07656   320 SGVTTFNR-----LDDDRktvAGTIGTAIAGVENKIVNELGEEVPVGEVGELLVRGPNVMKGYYDDPEATAAAIDAD--- 391

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1947 ttgGRLYrTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVVL--PHEGPGAtqlVG--YVVTQ 2022
Cdd:PRK07656   392 ---GWLH-TGDLGRLDEEGYLYIVDRKKDMFIVGGFNVYPAEVEEVLYEHPAVAEAAVIgvPDERLGE---VGkaYVVLK 464

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2183974163 2023 -AAPSDPAALRDTLRqalkaslpEHM----VPAHLLFLERLPLTANGKLDRRAL 2071
Cdd:PRK07656   465 pGAELTEEELIAYCR--------EHLakykVPRSIEFLDELPKNATGKVLKRAL 510

FUM14_C_NRPS-like

Condensation domains of nonribosomal peptide synthetases (NRPSs) similar to the ester-bond ...

2638-3036

9.49e-60

Condensation domains of nonribosomal peptide synthetases (NRPSs) similar to the ester-bond forming Fusarium verticillioides FUM14 protein; Condensation (C) domains of nonribosomal peptide synthetases (NRPSs) typically catalyze peptide bond formation within (usually) large multi-modular enzymatic complexes. However, some C-domains have ester-bond forming activity. This subfamily includes Fusarium verticillioides FUM14 (also known as NRPS8), a bi-domain protein with an ester-bond forming NRPS C-domain, which catalyzes linkages between an aminoacyl/peptidyl-PCP donor and a hydroxyl-containing acceptor. C-domains typically have a conserved HHxxxD motif at the active site; mutations in this motif can abolish or diminish condensation activity. FUM14 has an altered active site motif DHTHCD instead of the typical HHxxxD motif seen in other subfamily members. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long (with various activities such as antibiotic, antifungal, antitumor and immunosuppression). There are various subtypes of C-domains such as the LCL-type which catalyzes peptide bond formation between two L-amino acids, the DCL-type which links an L-amino acid to the D-amino acid at the end of a growing peptide, starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and heterocyclization (Cyc) domains which catalyze both peptide bond formation and cyclization of Cys, Ser, or Thr residues. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the epimerization (E) domain, the ester-bond forming C-domain, dual E/C (epimerization and condensation) domains, and the X-domain.

Pssm-ID: 380467 [Multi-domain] Cd Length: 395 Bit Score: 212.16 E-value: 9.49e-60

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2638 YPLSPMQQGMLFHSLyqQNSGDYINQMRLDV-EGLDPQRFREAWQAALDAHEVLRSGFLwQGALEKPLQLVRKRVEVPfs 2716
Cdd:cd19545      2 YPCTPLQEGLMALTA--RQPGAYVGQRVFELpPDIDLARLQAAWEQVVQANPILRTRIV-QSDSGGLLQVVVKESPIS-- 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2717 vhdWRDRADLAEALDALAAGEAGLGfelaeAPLLRLVLVRTGERRHHLIYTNHHILMDGWSNSQLLGEVLQRYRGETPSR 2796
Cdd:cd19545     77 ---WTESTSLDEYLEEDRAAPMGLG-----GPLVRLALVEDPDTERYFVWTIHHALYDGWSLPLILRQVLAAYQGEPVPQ 148

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2797 SDGrYRDYIAWLQRQDAGRTEAFWKQRLQRLGEPtllvPAFAHGVRGAEGHADRYRQLDVTTSQRlaefaREQKVTLNTL 2876
Cdd:cd19545    149 PPP-FSRFVKYLRQLDDEAAAEFWRSYLAGLDPA----VFPPLPSSRYQPRPDATLEHSISLPSS-----ASSGVTLATV 218

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2877 VQAAWLILLQRFTGQDTVAFGATVSGRPAELRGIEEQIGLFINTLPVVASPCPEQPIGDWLQAVQGENLALREFEHTPLY 2956
Cdd:cd19545    219 LRAAWALVLSRYTGSDDVVFGVTLSGRNAPVPGIEQIVGPTIATVPLRVRIDPEQSVEDFLQTVQKDLLDMIPFEHTGLQ 298

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2957 DIQRWAGQVGEAL-FDNILV----FENYPVSAALAEETPADMRIDALSNqeqthYPLTLLVS-AGETLELHYSYSRQAFD 3030
Cdd:cd19545    299 NIRRLGPDARAACnFQTLLVvqpaLPSSTSESLELGIEEESEDLEDFSS-----YGLTLECQlSGSGLRVRARYDSSVIS 373


                   ....*.
gi 2183974163 3031 EAAIEC 3036
Cdd:cd19545    374 EEQVER 379

PRK06187

long-chain-fatty-acid--CoA ligase; Validated

512-1007

1.48e-59

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 235730 [Multi-domain] Cd Length: 521 Bit Score: 215.82 E-value: 1.48e-59

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  512 VHRLFEAQAGLTPDAPALLFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLD 591
Cdd:PRK06187     8 IGRILRHGARKHPDKEAVYFDGRRTTYAELDERVNRLANALRALGVKKGDRVAVFDWNSHEYLEAYFAVPKIGAVLHPIN 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  592 PQYPADRLQYMIDDSGLRLLLSQQSVLARL----PQSDGLQS-LLLDDLER-----LVHGYP---AENPDLPEAPD---- 654
Cdd:PRK06187    88 IRLKPEEIAYILNDAEDRVVLVDSEFVPLLaailPQLPTVRTvIVEGDGPAaplapEVGEYEellAAASDTFDFPDiden 167

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  655 SLCYAIYTSGSTGQPKGVMVRHRALTNFVCSIARQPGMLARDRLLSVTTFsFDIFGLEL-YVPLARGASMLLASReqaQD 733
Cdd:PRK06187   168 DAAAMLYTSGTTGHPKGVVLSHRNLFLHSLAVCAWLKLSRDDVYLVIVPM-FHVHAWGLpYLALMAGAKQVIPRR---FD 243

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  734 PEALLDLVERQGVTVLQATPATWRMLCDSER---VDL--LRgcTLLCGGEALAEDLAARMRG-LSASTWNLYGPTET--T 805
Cdd:PRK06187   244 PENLLDLIETERVTFFFAVPTIWQMLLKAPRayfVDFssLR--LVIYGGAALPPALLREFKEkFGIDLVQGYGMTETspV 321

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  806 IWSARFRLGEEARPFL----GGPLENTALYILDSEMNPCPP--GVAGELLIGGDGLARGYHRRPGLTAERFlpdpfaADG 879
Cdd:PRK06187   322 VSVLPPEDQLPGQWTKrrsaGRPLPGVEARIVDDDGDELPPdgGEVGEIIVRGPWLMQGYWNRPEATAETI------DGG 395

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  880 srLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQPGVA-GPTLVAYLVPTEAALVD 958
Cdd:PRK06187   396 --WLHTGDVGYIDEDGYLYITDRIKDVIISGGENIYPRELEDALYGHPAVAEVAVIGVPDEKwGERPVAVVVLKPGATLD 473

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*....
gi 2183974163  959 AEsarqqelrsALKNSLLAVLPDYMVPAHMLLLENLPLTPNGKINRKAL 1007
Cdd:PRK06187   474 AK---------ELRAFLRGRLAKFKLPKRIAFVDELPRTSVGKILKRVL 513

PRK06187

long-chain-fatty-acid--CoA ligase; Validated

1570-2071

3.63e-59

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 235730 [Multi-domain] Cd Length: 521 Bit Score: 214.67 E-value: 3.63e-59

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1570 LHRLIERQAAERPRATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLD 1649
Cdd:PRK06187     8 IGRILRHGARKHPDKEAVYFDGRRTTYAELDERVNRLANALRALGVKKGDRVAVFDWNSHEYLEAYFAVPKIGAVLHPIN 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1650 PRYPSDRLGYMIEDSGIRLLLTQ-------RAARERLP-------LGEGLPCLLLDAEHEW----AGYPESDPQSAVGVD 1711
Cdd:PRK06187    88 IRLKPEEIAYILNDAEDRVVLVDsefvpllAAILPQLPtvrtvivEGDGPAAPLAPEVGEYeellAAASDTFDFPDIDEN 167

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1712 NLAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRHWFGFSADD----AWSLFHSYAFDFSVweifGALLHGGRLVIVP-YE 1786
Cdd:PRK06187   168 DAAAMLYTSGTTGHPKGVVLSHRNLFLHSLAVCAWLKLSRDDvylvIVPMFHVHAWGLPY----LALMAGAKQVIPRrFD 243

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1787 tsrsPEDFLRLLCRERVTVLNQTPSAFKQLMQ-VACAGQEVPPlaLRHVVFGGEALEVQALRPWFERFGdraPRLVNMYG 1865
Cdd:PRK06187   244 ----PENLLDLIETERVTFFFAVPTIWQMLLKaPRAYFVDFSS--LRLVIYGGAALPPALLREFKEKFG---IDLVQGYG 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1866 ITETTVHVTYRPLSlADLDGGAASPI--GEPIPDLSWYLLDAGLNPVPR--GCIGELYVGGAGLARGYLNRPELSCTRFV 1941
Cdd:PRK06187   315 MTETSPVVSVLPPE-DQLPGQWTKRRsaGRPLPGVEARIVDDDGDELPPdgGEVGEIIVRGPWLMQGYWNRPEATAETID 393

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1942 ADpfsttggrLYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVVL--PHEGPGATQLVGYV 2019
Cdd:PRK06187   394 GG--------WLHTGDVGYIDEDGYLYITDRIKDVIISGGENIYPRELEDALYGHPAVAEVAVIgvPDEKWGERPVAVVV 465

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2183974163 2020 VTQAAPSDPAALRDTLRQalkaSLPEHMVPAHLLFLERLPLTANGKLDRRAL 2071
Cdd:PRK06187   466 LKPGATLDAKELRAFLRG----RLAKFKLPKRIAFVDELPRTSVGKILKRVL 513

PRK05691

peptide synthase; Validated

1566-2623

5.11e-59

peptide synthase; Validated

Pssm-ID: 235564 [Multi-domain] Cd Length: 4334 Bit Score: 228.13 E-value: 5.11e-59

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1566 PASCLHRLiERQAAERPRATAVVY------GERALDYGELNLRANRLAHRLIELGVGPDVLVgLAAERSLEMIVGLLAIL 1639
Cdd:PRK05691     8 PLTLVQAL-QRRAAQTPDRLALRFladdpgEGVVLSYRDLDLRARTIAAALQARASFGDRAV-LLFPSGPDYVAAFFGCL 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1640 KAGGAYVPLDP-----RYPSDRLGYMIEDSGIRLLLTQRAARERLplgEGLPCLLLDAEHEWAGYPESDPQSA------- 1707
Cdd:PRK05691    86 YAGVIAVPAYPpesarRHHQERLLSIIADAEPRLLLTVADLRDSL---LQMEELAAANAPELLCVDTLDPALAeawqepa 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1708 VGVDNLAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRHWFGFSADD-----AW-SLFHSYAfdfsvweIFGALLHG---- 1777
Cdd:PRK05691   163 LQPDDIAFLQYTSGSTALPKGVQVSHGNLVANEQLIRHGFGIDLNPddvivSWlPLYHDMG-------LIGGLLQPifsg 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1778 ------------GRLV-----IVPYE-TSRSPEDFLRLLCRERVTvlnqtPSAFKQLmqvacagqevpPLALRHVVF-GG 1838
Cdd:PRK05691   236 vpcvlmspayflERPLrwleaISEYGgTISGGPDFAYRLCSERVS-----ESALERL-----------DLSRWRVAYsGS 299

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1839 EALEVQALRPWFERF---GDRAPRLVNMYGITETTVHVTY----RPLSLADLDG----------GAASPI---GEPIPDL 1898
Cdd:PRK05691   300 EPIRQDSLERFAEKFaacGFDPDSFFASYGLAEATLFVSGgrrgQGIPALELDAealarnraepGTGSVLmscGRSQPGH 379

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1899 SWYLLD-AGLNPVPRGCIGELYVGGAGLARGYLNRPELSCTRFVadpfSTTGGRLYRTGDLARYRcDGVVEYVGRIDHQV 1977
Cdd:PRK05691   380 AVLIVDpQSLEVLGDNRVGEIWASGPSIAHGYWRNPEASAKTFV----EHDGRTWLRTGDLGFLR-DGELFVTGRLKDML 454

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1978 KIRGFRIELGEIEARL-----LAQPGVAEAVVLPH---EGPGATQLVGYVVTQAAPsdPAALRDTLRQALKASLPEhmVP 2049
Cdd:PRK05691   455 IVRGHNLYPQDIEKTVereveVVRKGRVAAFAVNHqgeEGIGIAAEISRSVQKILP--PQALIKSIRQAVAEACQE--AP 530

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2050 AHLLFLE--RLPLTANGKLDRRA---------------LPAPDASrLQRDYTAPRSELEQRLAAIWADVLKLGRVGLDDN 2112
Cdd:PRK05691   531 SVVLLLNpgALPKTSSGKLQRSAcrlrladgsldsyalFPALQAV-EAAQTAASGDELQARIAAIWCEQLKVEQVAADDH 609

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2113 FFELGGDSIISIQVVSRARQA-GIRLAPRDLFLHQTIRGLAgvAVEGRGLacAEQGPISGSTPLLPIQQMF--------- 2182
Cdd:PRK05691   610 FFLLGGNSIAATQVVARLRDElGIDLNLRQLFEAPTLAAFS--AAVARQL--AGGGAAQAAIARLPRGQALpqslaqnrl 685

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2183 ---FELDiPRRQHWNQSVLLEPGQALDGTLLETALQALLAHHDALRLGFRLEDGTwrAEHRAVEAGEVLLWQQSVAD--- 2256
Cdd:PRK05691   686 wllWQLD-PQSAAYNIPGGLHLRGELDEAALRASFQRLVERHESLRTRFYERDGV--ALQRIDAQGEFALQRIDLSDlpe 762

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2257 ----GQALEALAEQVQRSLDLGSGPLLRALLATLGDGSQRLLLVIHHLVVDGVSWRILLEDLQTAYRQLQAGQAVALPAK 2332
Cdd:PRK05691   763 aereARAAQIREEEARQPFDLEKGPLLRVTLVRLDDEEHQLLVTLHHIVADGWSLNILLDEFSRLYAAACQGQTAELAPL 842

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2333 TSAFKAWAERLQAHARDGGLEGERGYWLAQLEGVSTELP-CDDREGAQSVRHVRSARTELTEEATRRLLQEAPAAYRTQV 2411
Cdd:PRK05691   843 PLGYADYGAWQRQWLAQGEAARQLAYWKAQLGDEQPVLElATDHPRSARQAHSAARYSLRVDASLSEALRGLAQAHQATL 922

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2412 NDLLLTALARVIGRWTGQADTLIQLEGHGREELfediDLTRTVGWFTSLFPLRLS-----PVAELGASIKRIKEQLRAip 2486
Cdd:PRK05691   923 FMVLLAAFQALLHRYSGQGDIRIGVPNANRPRL----ETQGLVGFFINTQVLRAQldgrlPFTALLAQVRQATLGAQA-- 996

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2487 HKGLGFGALrylgsaedraaLAALPSPRITfnylGQFDGSFS---ADSSALFRPSADAAGS--ERDSDAPLDnwLSLNGQ 2561
Cdd:PRK05691   997 HQDLPFEQL-----------VEALPQAREQ----GLFQVMFNhqqRDLSALRRLPGLLAEElpWHSREAKFD--LQLHSE 1059

                         1130      1140      1150      1160      1170      1180
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2183974163 2562 V-YAGRLGIDWSFSAARFSEASILRLADAYrdelLALIEHCCAADVEGVtpSDFPLAGLDQRQ 2623
Cdd:PRK05691  1060 EdRNGRLTLSFDYAAELFDAATIERLAEHF----LALLEQVCEDPQRAL--GDVQLLDAAERA 1116

A_NRPS_alphaAR

cd17647

Alpha-aminoadipate reductase; This family contains L-2-aminoadipate reductase, also known as ...

537-1010

5.39e-57

Alpha-aminoadipate reductase; This family contains L-2-aminoadipate reductase, also known as alpha-aminoadipate reductase (EC 1.2.1.95) or alpha-AR or L-aminoadipate-semialdehyde dehydrogenase (EC 1.2.1.31), which catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate.

Pssm-ID: 341302 [Multi-domain] Cd Length: 520 Bit Score: 208.14 E-value: 5.39e-57

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  537 SYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRlqymiddsglrlllsqQS 616
Cdd:cd17647     22 TYRDINEASNIVAHYLIKTGIKRGDVVMIYSYRGVDLMVAVMGVLKAGATFSVIDPAYPPAR----------------QN 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  617 VLARLPQSDGLQSLllddlerlvhgypaENPDLPEAPDSLCYAIYTSGSTGQPKGVMVRHRALTNFVCSIARQPGMLARD 696
Cdd:cd17647     86 IYLGVAKPRGLIVI--------------RAAGVVVGPDSNPTLSFTSGSEGIPKGVLGRHFSLAYYFPWMAKRFNLSEND 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  697 RLLSVTTFSFDIFGLELYVPLARGASMLLASREQAQDPEALLDLVERQGVTVLQATPATWRML---CDSERVDLLRGCTL 773
Cdd:cd17647    152 KFTMLSGIAHDPIQRDMFTPLFLGAQLLVPTQDDIGTPGRLAEWMAKYGATVTHLTPAMGQLLtaqATTPFPKLHHAFFV 231

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  774 lcgGEALAEDLAARMRGLS--ASTWNLYGPTETTIWSARFRLGEEAR--PFL---------GGPLENTALYILD--SEMN 838
Cdd:cd17647    232 ---GDILTKRDCLRLQTLAenVRIVNMYGTTETQRAVSYFEVPSRSSdpTFLknlkdvmpaGRGMLNVQLLVVNrnDRTQ 308

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  839 PCPPGVAGELLIGGDGLARGYHRRPGLTAERFLPDPFAADG---------------------SRLYRTGDLARYRADGVI 897
Cdd:cd17647    309 ICGIGEVGEIYVRAGGLAEGYRGLPELNKEKFVNNWFVEPDhwnyldkdnnepwrqfwlgprDRLYRTGDLGRYLPNGDC 388

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  898 EYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQPGVAG-PTLVAYLVPTEAALVDAESA-------------- 962
Cdd:cd17647    389 ECCGRADDQVKIRGFRIELGEIDTHISQHPLVRENITLVRRDKDEePTLVSYIVPRFDKPDDESFAqedvpkevstdpiv 468

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2183974163  963 ----RQQELRSALKNSLLAVLPDYMVPAHMLLLENLPLTPNGKINRKALPLP 1010
Cdd:cd17647    469 kgliGYRKLIKDIREFLKKRLASYAIPSLIVVLDKLPLNPNGKVDKPKLQFP 520

FACL_like_6

cd05922

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ...

1601-2071

3.48e-56

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.

Pssm-ID: 341246 [Multi-domain] Cd Length: 457 Bit Score: 203.83 E-value: 3.48e-56

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1601 LRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGA----YVPLDPRYPSDRLGYMIEDSGIRLLLTQRAAR 1676
Cdd:cd05922      1 LGVSAAASALLEAGGVRGERVVLILPNRFTYIELSFAVAYAGGRlglvFVPLNPTLKESVLRYLVADAGGRIVLADAGAA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1677 ERLPLGE---GLPCLLLDAEhEWAGYPESDPQSAVGVDNLAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRHWFGFSADD 1753
Cdd:cd05922     81 DRLRDALpasPDPGTVLDAD-GIRAARASAPAHEVSHEDLALLLYTSGSTGSPKLVRLSHQNLLANARSIAEYLGITADD 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1754 AWSLFHSYAFDFSVWEIFGALLHGGRLVIVPyeTSRSPEDFLRLLCRERVTVLNQTPSAFKQLMQVACAGQEVPplALRH 1833
Cdd:cd05922    160 RALTVLPLSYDYGLSVLNTHLLRGATLVLTN--DGVLDDAFWEDLREHGATGLAGVPSTYAMLTRLGFDPAKLP--SLRY 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1834 VVFGGEALEVQALRpwfeRFGDRAP--RLVNMYGITETTVHVTYRPlslADLDGGAASPIGEPIPDLSWYLLDAGLNPVP 1911
Cdd:cd05922    236 LTQAGGRLPQETIA----RLRELLPgaQVYVMYGQTEATRRMTYLP---PERILEKPGSIGLAIPGGEFEILDDDGTPTP 308

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1912 RGCIGELYVGGAGLARGYLNRPElsctrFVADPfSTTGGRLYrTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEA 1991
Cdd:cd05922    309 PGEPGEIVHRGPNVMKGYWNDPP-----YRRKE-GRGGGVLH-TGDLARRDEDGFLFIVGRRDRMIKLFGNRISPTEIEA 381

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1992 RLLAQPGVAEAVVLPHEGPgATQLVGYVVTQAAPSDPAALRDTLRqalkASLPEHMVPAHLLFLERLPLTANGKLDRRAL 2071
Cdd:cd05922    382 AARSIGLIIEAAAVGLPDP-LGEKLALFVTAPDKIDPKDVLRSLA----ERLPPYKVPATVRVVDELPLTASGKVDYAAL 456

FACL_DitJ_like

cd05934

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ...

1596-2072

1.01e-55

Pssm-ID: 341257 [Multi-domain] Cd Length: 422 Bit Score: 201.37 E-value: 1.01e-55

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1596 YGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGYMIEDSGIRLLLTqraa 1675
Cdd:cd05934      6 YAELLRESARIAAALAALGIRPGDRVALMLDNCPEFLFAWFALAKLGAVLVPINTALRGDELAYIIDHSGAQLVVV---- 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1676 rerlplgeglpcllldaehewagypesdpqsavgvdNLAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRHWFGFSADD-- 1753
Cdd:cd05934     82 ------------------------------------DPASILYTSGTTGPPKGVVITHANLTFAGYYSARRFGLGEDDvy 125

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1754 --AWSLFHSYAfdfSVWEIFGALLHGGRLVIVP-YETSRspedFLRLLCRERVTVLNQTPSAFKQLMQvacagQEVPPLA 1830
Cdd:cd05934    126 ltVLPLFHINA---QAVSVLAALSVGATLVLLPrFSASR----FWSDVRRYGATVTNYLGAMLSYLLA-----QPPSPDD 193

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1831 LRH---VVFGGEALEvQALRPWFERFGdraPRLVNMYGITETTVHVtyrplsLADLDG-GAASPIGEPIPDLSWYLLDAG 1906
Cdd:cd05934    194 RAHrlrAAYGAPNPP-ELHEEFEERFG---VRLLEGYGMTETIVGV------IGPRDEpRRPGSIGRPAPGYEVRIVDDD 263

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1907 LNPVPRGCIGELYV---GGAGLARGYLNRPELSCTRFvadpfstTGGrLYRTGDLARYRCDGVVEYVGRIDHQVKIRGFR 1983
Cdd:cd05934    264 GQELPAGEPGELVIrglRGWGFFKGYYNMPEATAEAM-------RNG-WFHTGDLGYRDADGFFYFVDRKKDMIRRRGEN 335

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1984 IELGEIEARLLAQPGVAEAVV--LPHEGPGATQLVGYVVTQAAPSDPAALRDTLRQalkaSLPEHMVPAHLLFLERLPLT 2061
Cdd:cd05934    336 ISSAEVERAILRHPAVREAAVvaVPDEVGEDEVKAVVVLRPGETLDPEELFAFCEG----QLAYFKVPRYIRFVDDLPKT 411

                          490
                   ....*....|.
gi 2183974163 2062 ANGKLDRRALP 2072
Cdd:cd05934    412 PTEKVAKAQLR 422

A_NRPS_alphaAR

cd17647

Alpha-aminoadipate reductase; This family contains L-2-aminoadipate reductase, also known as ...

1592-2074

1.19e-55

Pssm-ID: 341302 [Multi-domain] Cd Length: 520 Bit Score: 204.29 E-value: 1.19e-55

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1592 RALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSdrlgymiedsgirlllt 1671
Cdd:cd17647     19 RSFTYRDINEASNIVAHYLIKTGIKRGDVVMIYSYRGVDLMVAVMGVLKAGATFSVIDPAYPP----------------- 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1672 qraARERLPLGEGLPCLLLDAEHewAGYpesdpqsAVGVDNLAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRHWFGFSA 1751
Cdd:cd17647     82 ---ARQNIYLGVAKPRGLIVIRA--AGV-------VVGPDSNPTLSFTSGSEGIPKGVLGRHFSLAYYFPWMAKRFNLSE 149

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1752 DDAWSLFHSYAFDFSVWEIFGALLHGGRLVIVPYETSRSPEDFLRLLCRERVTVLNQTPSafkqLMQVACAGQEVPPLAL 1831
Cdd:cd17647    150 NDKFTMLSGIAHDPIQRDMFTPLFLGAQLLVPTQDDIGTPGRLAEWMAKYGATVTHLTPA----MGQLLTAQATTPFPKL 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1832 RHVVFGGEAL------EVQALRPWFerfgdrapRLVNMYGITETTVHVTYRPLSLADLDGGAASPIGEPIPD----LSWY 1901
Cdd:cd17647    226 HHAFFVGDILtkrdclRLQTLAENV--------RIVNMYGTTETQRAVSYFEVPSRSSDPTFLKNLKDVMPAgrgmLNVQ 297

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1902 LLDAGLNPVPRGC----IGELYVGGAGLARGYLNRPELSCTRFVADPFSTTG---------------------GRLYRTG 1956
Cdd:cd17647    298 LLVVNRNDRTQICgigeVGEIYVRAGGLAEGYRGLPELNKEKFVNNWFVEPDhwnyldkdnnepwrqfwlgprDRLYRTG 377

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1957 DLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVVL-PHEGPGATQLVGYVVTQAAP---------- 2025
Cdd:cd17647    378 DLGRYLPNGDCECCGRADDQVKIRGFRIELGEIDTHISQHPLVRENITLvRRDKDEEPTLVSYIVPRFDKpddesfaqed 457

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2183974163 2026 ------SDPAA--------LRDTLRQALKASLPEHMVPAHLLFLERLPLTANGKLDRRALPAP 2074
Cdd:cd17647    458 vpkevsTDPIVkgligyrkLIKDIREFLKKRLASYAIPSLIVVLDKLPLNPNGKVDKPKLQFP 520

MCS

cd05941

Malonyl-CoA synthetase (MCS); MCS catalyzes the formation of malonyl-CoA in a two-step ...

1584-2071

1.80e-55

Malonyl-CoA synthetase (MCS); MCS catalyzes the formation of malonyl-CoA in a two-step reaction consisting of the adenylation of malonate with ATP, followed by malonyl transfer from malonyl-AMP to CoA. Malonic acid and its derivatives are the building blocks of polyketides and malonyl-CoA serves as the substrate of polyketide synthases. Malonyl-CoA synthetase has broad substrate tolerance and can activate a variety of malonyl acid derivatives. MCS may play an important role in biosynthesis of polyketides, the important secondary metabolites with therapeutic and agrochemical utility.

Pssm-ID: 341264 [Multi-domain] Cd Length: 442 Bit Score: 201.36 E-value: 1.80e-55

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1584 ATAVVYGERALDYGELNLRANRLAHRLIELG-VGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGYMIE 1662
Cdd:cd05941      2 RIAIVDDGDSITYADLVARAARLANRLLALGkDLRGDRVAFLAPPSAEYVVAQLAIWRAGGVAVPLNPSYPLAELEYVIT 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1663 DSGIRLLLtqraarerlplgeglpcllldaehewagypesdpqsavgvdNLAYVIYTSGSTGKPKGTLLPHGNVLRLFDA 1742
Cdd:cd05941     82 DSEPSLVL-----------------------------------------DPALILYTSGTTGRPKGVVLTHANLAANVRA 120

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1743 TRHWFGFSADD----AWSLFHSYAFdfsVWEIFGALLHGGRLVIVPyetSRSPEDFLRLLCRERVTV----------LNQ 1808
Cdd:cd05941    121 LVDAWRWTEDDvllhVLPLHHVHGL---VNALLCPLFAGASVEFLP---KFDPKEVAISRLMPSITVfmgvptiytrLLQ 194

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1809 TPSAFKQLMQVACAgqeVPPLALRHVVFGGEALEVQALRPWFERFGDrapRLVNMYGITETTVHVTyRPLSLADLDGGaa 1888
Cdd:cd05941    195 YYEAHFTDPQFARA---AAAERLRLMVSGSAALPVPTLEEWEAITGH---TLLERYGMTEIGMALS-NPLDGERRPGT-- 265

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1889 spIGEPIPDLSWYLLD-AGLNPVPRGCIGELYVGGAGLARGYLNRPELSCTRFVADPFsttggrlYRTGDLARYRCDGVV 1967
Cdd:cd05941    266 --VGMPLPGVQARIVDeETGEPLPRGEVGEIQVRGPSVFKEYWNKPEATKEEFTDDGW-------FKTGDLGVVDEDGYY 336

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1968 EYVGRI-DHQVKIRGFRIELGEIEARLLAQPGVAEAVV--LPHEGPGatQLVGYVVTQAAPSDPAALRDtLRQALKASLP 2044
Cdd:cd05941    337 WILGRSsVDIIKSGGYKVSALEIERVLLAHPGVSECAVigVPDPDWG--ERVVAVVVLRAGAAALSLEE-LKEWAKQRLA 413

                          490       500
                   ....*....|....*....|....*..
gi 2183974163 2045 EHMVPAHLLFLERLPLTANGKLDRRAL 2071
Cdd:cd05941    414 PYKRPRRLILVDELPRNAMGKVNKKEL 440

A_NRPS_acs4

cd17654

acyl-CoA synthetase family member 4; This family of the adenylation (A) domain of nonribosomal ...

1596-2071

5.11e-55

Pssm-ID: 341309 [Multi-domain] Cd Length: 449 Bit Score: 200.39 E-value: 5.11e-55

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1596 YGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGYMIEDSGIRLLLTQraa 1675
Cdd:cd17654     19 YADLAEKISNLSNFLRKKFQTEERAIGLRCDRGTESPVAILAILFLGAAYAPIDPASPEQRSLTVMKKCHVSYLLQN--- 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1676 rerlplgeglpCLLLDAehewagyPESDPQSAVGVD-----NLAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRHWFGFS 1750
Cdd:cd17654     96 -----------KELDNA-------PLSFTPEHRHFNirtdeCLAYVIHTSGTTGTPKIVAVPHKCILPNIQHFRSLFNIT 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1751 ADDAWSLFHSYAFDFSVWEIFGALLHGGRLVIVPYETSRSPEDFLRLL-CRERVTVLNQTPSAFKQLMQVACAGQEVPPL 1829
Cdd:cd17654    158 SEDILFLTSPLTFDPSVVEIFLSLSSGATLLIVPTSVKVLPSKLADILfKRHRITVLQATPTLFRRFGSQSIKSTVLSAT 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1830 -ALRHVVFGGEAL----EVQALRPWFERFgdrapRLVNMYGITETTVHVTYRPLSladlDGGAASPIGEPIPDLSWYLLD 1904
Cdd:cd17654    238 sSLRVLALGGEPFpslvILSSWRGKGNRT-----RIFNIYGITEVSCWALAYKVP----EEDSPVQLGSPLLGTVIEVRD 308

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1905 AGLNPVPrgciGELYVGgaGLARGYlnrpelsctrFVADPFSTTGGRLYRTGDLARyRCDGVVEYVGRIDHQVKIRGFRI 1984
Cdd:cd17654    309 QNGSEGT----GQVFLG--GLNRVC----------ILDDEVTVPKGTMRATGDFVT-VKDGELFFLGRKDSQIKRRGKRI 371

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1985 ELGEIEARLLAQPGVAEAVVLPHEgpgATQLVGYVVTQaaPSDpAALRDTLRqalKASLPEHMVPAHLLFLERLPLTANG 2064
Cdd:cd17654    372 NLDLIQQVIESCLGVESCAVTLSD---QQRLIAFIVGE--SSS-SRIHKELQ---LTLLSSHAIPDTFVQIDKLPLTSHG 442


                   ....*..
gi 2183974163 2065 KLDRRAL 2071
Cdd:cd17654    443 KVDKSEL 449

C_NRPS-like

Condensation domain of nonribosomal peptide synthetases (NRPSs); Condensation (C) domains of ...

2174-2601

5.72e-54

Pssm-ID: 380453 [Multi-domain] Cd Length: 427 Bit Score: 196.48 E-value: 5.72e-54

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2174 PLLPIQQMFFELDI--PRRQHWNQSVLLEPGQALDGTLLETALQALLAHHDALRLGFRLEDGT---WRAEHRAVEAGEVL 2248
Cdd:cd19066      3 PLSPMQRGMWFLKKlaTDPSAFNVAIEMFLTGSLDLARLKQALDAVMERHDVLRTRFCEEAGRyeqVVLDKTVRFRIEII 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2249 -LWQQSVADGQALEALAEQVQRSLDLGSGPLLRALLATLGDGSQRLLLVIHHLVVDGVSWRILLEDLQTAYRQLQAGQAV 2327
Cdd:cd19066     83 dLRNLADPEARLLELIDQIQQTIYDLERGPLVRVALFRLADERDVLVVAIHHIIVDGGSFQILFEDISSVYDAAERQKPT 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2328 ALPAKTSaFKAWAERLQAHARDGGLEGERGYWLAQLEGVSTE--LPCDDREGAQSVRHVRSARTELTEEATRRLLQEApA 2405
Cdd:cd19066    163 LPPPVGS-YADYAAWLEKQLESEAAQADLAYWTSYLHGLPPPlpLPKAKRPSQVASYEVLTLEFFLRSEETKRLREVA-R 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2406 AYRTQVNDLLLTALARVIGRWTGQADTLIQLEGHGReelfEDIDLTRTVGWFTSLFPLRL--SPVAELGASIKRIKEQLR 2483
Cdd:cd19066    241 ESGTTPTQLLLAAFALALKRLTASIDVVIGLTFLNR----PDEAVEDTIGLFLNLLPLRIdtSPDATFPELLKRTKEQSR 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2484 AIPHKGLGFGALRYLGSAEDRAAlAALPSPRITFNYLGQFDGSFSADSSALFRPsaDAAGSERdsdAPLDNWLSLNGQVy 2563
Cdd:cd19066    317 EAIEHQRVPFIELVRHLGVVPEA-PKHPLFEPVFTFKNNQQQLGKTGGFIFTTP--VYTSSEG---TVFDLDLEASEDP- 389

                          410       420       430
                   ....*....|....*....|....*....|....*...
gi 2183974163 2564 AGRLGIDWSFSAARFSEASILRLADAYRDELLALIEHC 2601
Cdd:cd19066    390 DGDLLLRLEYSRGVYDERTIDRFAERYMTALRQLIENP 427

NRPS-para261

TIGR01720

non-ribosomal peptide synthase domain TIGR01720; This domain appears to be located immediately ...

2470-2627

6.64e-54

non-ribosomal peptide synthase domain TIGR01720; This domain appears to be located immediately downstream from a condensation domain (pfam00668), and is followed primarily by the end of the molecule or another condensation domain (in a few cases it is followed by pfam00501, an AMP-binding module). The converse is not true, pfam00668 domains are not always followed by this domain. This implicates this domain in possible post-condensation modification events. This model is 171 amino acids long and contains three very highly conserved regions. At the N-terminus is a nearly invariant lysine (position 11) followed by xxxRxxPxxGxGYG in which the proline and the first glycine are invariant. This is followed approximately 22 residues later by the motif FNYLG. Near the C-terminus of the domain is the sequence TxSD where the serine and aspartate are nearly invariant.

Pssm-ID: 273774 [Multi-domain] Cd Length: 153 Bit Score: 186.33 E-value: 6.64e-54

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2470 ELGASIKRIKEQLRAIPHKGLGFGALRYLgsAEDRAALAALPSPRITFNYLGQFDGSfsaDSSALFRPSADAAGSERDSD 2549
Cdd:TIGR01720    1 ELGRLIKAVKEQLRRIPNKGVGYGVLRYL--TEPEEKLAASPQPEISFNYLGQFDAD---SNDELFQPSSYSPGEAISPE 75

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2183974163 2550 APLDNWLSLNGQVYAGRLGIDWSFSAARFSEASILRLADAYRDELLALIEHCCAADVEGVTPSDFPLAGLDQRQLDAL 2627
Cdd:TIGR01720   76 SPRPYALEINAMIEDGELTLTWSYPTQLFSEDTIEQLADRFKEALEALIAHCAGKEGGGLTPSDFSLKDLTQDELDEL 153

BCL_4HBCL

cd05959

Benzoate CoA ligase (BCL) and 4-Hydroxybenzoate-Coenzyme A Ligase (4-HBA-CoA ligase); Benzoate ...

1572-2071

1.27e-53

Benzoate CoA ligase (BCL) and 4-Hydroxybenzoate-Coenzyme A Ligase (4-HBA-CoA ligase); Benzoate CoA ligase and 4-hydroxybenzoate-coenzyme A ligase catalyze the first activating step for benzoate and 4-hydroxybenzoate catabolic pathways, respectively. Although these two enzymes share very high sequence homology, they have their own substrate preference. The reaction proceeds via a two-step process; the first ATP-dependent step forms the substrate-AMP intermediate, while the second step forms the acyl-CoA ester, releasing the AMP. Aromatic compounds represent the second most abundant class of organic carbon compounds after carbohydrates. Some bacteria can use benzoic acid or benzenoid compounds as the sole source of carbon and energy through degradation. Benzoate CoA ligase and 4-hydroxybenzoate-Coenzyme A ligase are key enzymes of this process.

Pssm-ID: 341269 [Multi-domain] Cd Length: 508 Bit Score: 197.98 E-value: 1.27e-53

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1572 RLIERQAAE-RPRATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDP 1650
Cdd:cd05959      7 TLVDLNLNEgRGDKTAFIDDAGSLTYAELEAEARRVAGALRALGVKREERVLLIMLDTVDFPTAFLGAIRAGIVPVPVNT 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1651 RYPSDRLGYMIEDSGIRLLLT--------QRAARERLPL--------GEGLPCLLLDAEHEWAGYPESDPQSAVGVDNLA 1714
Cdd:cd05959     87 LLTPDDYAYYLEDSRARVVVVsgelapvlAAALTKSEHTlvvlivsgGAGPEAGALLLAELVAAEAEQLKPAATHADDPA 166

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1715 YVIYTSGSTGKPKGTLLPHGN---VLRLFdaTRHWFGFSADD----AWSLFHSYAFDFSVWEIFGAllhGGRLVIVPyet 1787
Cdd:cd05959    167 FWLYSSGSTGRPKGVVHLHADiywTAELY--ARNVLGIREDDvcfsAAKLFFAYGLGNSLTFPLSV---GATTVLMP--- 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1788 SR-SPEDFLRLLCRERVTVLNQTPSAFKQLMQVACAGQEvPPLALRHVVFGGEALEVQALRPWFERFGdraPRLVNMYGI 1866
Cdd:cd05959    239 ERpTPAAVFKRIRRYRPTVFFGVPTLYAAMLAAPNLPSR-DLSSLRLCVSAGEALPAEVGERWKARFG---LDILDGIGS 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1867 TETT-VHVTYRPlslADLDGGAAspiGEPIPDLSWYLLDAGLNPVPRGCIGELYVGGAGLARGYLNRPELSCTRFVadpf 1945
Cdd:cd05959    315 TEMLhIFLSNRP---GRVRYGTT---GKPVPGYEVELRDEDGGDVADGEPGELYVRGPSSATMYWNNRDKTRDTFQ---- 384

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1946 sttgGRLYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVVLPHEGP-GATQLVGYVVTQAA 2024
Cdd:cd05959    385 ----GEWTRTGDKYVRDDDGFYTYAGRADDMLKVSGIWVSPFEVESALVQHPAVLEAAVVGVEDEdGLTKPKAFVVLRPG 460

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*..
gi 2183974163 2025 PSDPAALRDTLRQALKASLPEHMVPAHLLFLERLPLTANGKLDRRAL 2071
Cdd:cd05959    461 YEDSEALEEELKEFVKDRLAPYKYPRWIVFVDELPKTATGKIQRFKL 507

COG4908

Uncharacterized conserved protein, contains a NRPS condensation (elongation) domain [General ...

2175-2412

1.40e-53

Uncharacterized conserved protein, contains a NRPS condensation (elongation) domain [General function prediction only];

Pssm-ID: 443936 [Multi-domain] Cd Length: 243 Bit Score: 189.09 E-value: 1.40e-53

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2175 LLPIQQMFFELDiPRRQHWNQSVLLEPGQALDGTLLETALQALLAHHDALRLGFRLEDGTWRAE-HRAVEAG-EVLLWQQ 2252
Cdd:COG4908      1 LSPAQKRFLFLE-PGSNAYNIPAVLRLEGPLDVEALERALRELVRRHPALRTRFVEEDGEPVQRiDPDADLPlEVVDLSA 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2253 SVADGQ---ALEALAEQVQRSLDLGSGPLLRALLATLGDGSQRLLLVIHHLVVDGVSWRILLEDLQTAYRQLQAGQAVAL 2329
Cdd:COG4908     80 LPEPEReaeLEELVAEEASRPFDLARGPLLRAALIRLGEDEHVLLLTIHHIISDGWSLGILLRELAALYAALLEGEPPPL 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2330 PAKTSAFKAWAERLQAHARDGGLEGERGYWLAQLEGVS--TELPCDDREGAQSVRHVRSARTELTEEATRRLLQEApAAY 2407
Cdd:COG4908    160 PELPIQYADYAAWQRAWLQSEALEKQLEYWRQQLAGAPpvLELPTDRPRPAVQTFRGATLSFTLPAELTEALKALA-KAH 238


                   ....*
gi 2183974163 2408 RTQVN 2412
Cdd:COG4908    239 GATVN 243

MCS

cd05941

Malonyl-CoA synthetase (MCS); MCS catalyzes the formation of malonyl-CoA in a two-step ...

525-1007

2.35e-53

Pssm-ID: 341264 [Multi-domain] Cd Length: 442 Bit Score: 195.20 E-value: 2.35e-53

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  525 DAPALLFGEERLSYAELNALANRLAWRLREEG-VGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQYMI 603
Cdd:cd05941      1 DRIAIVDDGDSITYADLVARAARLANRLLALGkDLRGDRVAFLAPPSAEYVVAQLAIWRAGGVAVPLNPSYPLAELEYVI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  604 DDSGlrlllsqqsvlarlpqsdglQSLLLDDlerlvhgypaenpdlpeapdslCYAIYTSGSTGQPKGVMVRHRALTNFV 683
Cdd:cd05941     81 TDSE--------------------PSLVLDP----------------------ALILYTSGTTGRPKGVVLTHANLAANV 118

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  684 CSIARQPGMLARDRLLSVTTFsFDIFGL--ELYVPLARGASMLLASREqaqDPEALLDLVERQGVTVLQATPATWRMLCD 761
Cdd:cd05941    119 RALVDAWRWTEDDVLLHVLPL-HHVHGLvnALLCPLFAGASVEFLPKF---DPKEVAISRLMPSITVFMGVPTIYTRLLQ 194

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  762 S------ERVDLLRGCT-----LLCGGEALAEDLAARMRGLSAST-WNLYGPTETTIwSARFRLGEEARP-FLGGPLENT 828
Cdd:cd05941    195 YyeahftDPQFARAAAAerlrlMVSGSAALPVPTLEEWEAITGHTlLERYGMTEIGM-ALSNPLDGERRPgTVGMPLPGV 273

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  829 ALYILDSEMN-PCPPGVAGELLIGGDGLARGYHRRPGLTAERFLPDPFaadgsrlYRTGDLARYRADGVIEYLGRI-DHQ 906
Cdd:cd05941    274 QARIVDEETGePLPRGEVGEIQVRGPSVFKEYWNKPEATKEEFTDDGW-------FKTGDLGVVDEDGYYWILGRSsVDI 346

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  907 VKIRGFRIELGEIETRLLEQDSVREAVVVaqpGVAGPTL----VAYLVPTE-AALVDAEsarqqelrsALKNSLLAVLPD 981
Cdd:cd05941    347 IKSGGYKVSALEIERVLLAHPGVSECAVI---GVPDPDWgervVAVVVLRAgAAALSLE---------ELKEWAKQRLAP 414

                          490       500
                   ....*....|....*....|....*.
gi 2183974163  982 YMVPAHMLLLENLPLTPNGKINRKAL 1007
Cdd:cd05941    415 YKRPRRLILVDELPRNAMGKVNKKEL 440

BCL_like

cd05919

Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; This family contains benzoate ...

1585-2071

2.64e-52

Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; This family contains benzoate CoA ligase (BCL) and related ligases that catalyze the acylation of benzoate derivatives, 2-aminobenzoate and 4-hydroxybenzoate. Aromatic compounds represent the second most abundant class of organic carbon compounds after carbohydrates. Xenobiotic aromatic compounds are also a major class of man-made pollutants. Some bacteria use benzoate as the sole source of carbon and energy through benzoate degradation. Benzoate degradation starts with its activation to benzoyl-CoA by benzoate CoA ligase. The reaction catalyzed by benzoate CoA ligase proceeds via a two-step process; the first ATP-dependent step forms an acyl-AMP intermediate, and the second step forms the acyl-CoA ester with release of the AMP.

Pssm-ID: 341243 [Multi-domain] Cd Length: 436 Bit Score: 191.91 E-value: 2.64e-52

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1585 TAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGYMIEDS 1664
Cdd:cd05919      2 TAFYAADRSVTYGQLHDGANRLGSALRNLGVSSGDRVLLLMLDSPELVQLFLGCLARGAIAVVINPLLHPDDYAYIARDC 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1665 GIRLLLTQRaarerlplgeglpcllldaehewagypesdpqsavgvDNLAYVIYTSGSTGKPKGTLLPHGNVLRLFDA-T 1743
Cdd:cd05919     82 EARLVVTSA-------------------------------------DDIAYLLYSSGTTGPPKGVMHAHRDPLLFADAmA 124

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1744 RHWFGFSADD----AWSLFHSYAFDFSVWeifGALLHGGRLVIVPyeTSRSPEDFLRLLCRERVTVLNQTPSAFKQLMqV 1819
Cdd:cd05919    125 REALGLTPGDrvfsSAKMFFGYGLGNSLW---FPLAVGASAVLNP--GWPTAERVLATLARFRPTVLYGVPTFYANLL-D 198

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1820 ACAGQEVPPLALRHVVFGGEALEVQALRPWFERFGdraPRLVNMYGITETT-VHVTYRPlsladldgGAASP--IGEPIP 1896
Cdd:cd05919    199 SCAGSPDALRSLRLCVSAGEALPRGLGERWMEHFG---GPILDGIGATEVGhIFLSNRP--------GAWRLgsTGRPVP 267

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1897 DLSWYLLDAGLNPVPRGCIGELYVGGAGLARGYLNRPELSCTRFVadpfsttgGRLYRTGDLARYRCDGVVEYVGRIDHQ 1976
Cdd:cd05919    268 GYEIRLVDEEGHTIPPGEEGDLLVRGPSAAVGYWNNPEKSRATFN--------GGWYRTGDKFCRDADGWYTHAGRADDM 339

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1977 VKIRGFRIELGEIEARLLAQPGVAEAVVLP-HEGPGATQLVGYVVTqAAPSDPA-ALRDTLRQALKASLPEHMVPAHLLF 2054
Cdd:cd05919    340 LKVGGQWVSPVEVESLIIQHPAVAEAAVVAvPESTGLSRLTAFVVL-KSPAAPQeSLARDIHRHLLERLSAHKVPRRIAF 418

                          490
                   ....*....|....*..
gi 2183974163 2055 LERLPLTANGKLDRRAL 2071
Cdd:cd05919    419 VDELPRTATGKLQRFKL 435

starter-C_NRPS

Starter Condensation domains, found in the first module of nonribosomal peptide synthetases ...

1114-1535

7.79e-52

Starter Condensation domains, found in the first module of nonribosomal peptide synthetases (NRPSs); Condensation (C) domains of nonribosomal peptide synthetases (NRPSs) catalyze peptide bond formation within (usually) large multi-modular enzymatic complexes. While standard C-domains catalyze peptide bond formation between two amino acids, an initial, ('starter') C-domain may instead acylate an amino acid with a fatty acid. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long (with various activities such as antibiotic, antifungal, antitumor and immunosuppression). There are various subtypes of C-domains such as the LCL-type which catalyzes peptide bond formation between two L-amino acids, the DCL-type which links an L-amino acid to the D-amino acid at the end of a growing peptide, starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and heterocyclization (Cyc) domains which catalyze both peptide bond formation and cyclization of Cys, Ser, or Thr residues. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the epimerization (E) domain, the ester-bond forming C-domain, dual E/C (epimerization and condensation) domains, and the X-domain. C-domains typically have a conserved HHxxxD motif at the active site; mutations in this motif can abolish or diminish condensation activity.

Pssm-ID: 380456 [Multi-domain] Cd Length: 419 Bit Score: 190.27 E-value: 7.79e-52

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1114 LSFAQERQWFIWRLDPHSAAYNIPVALRLKGPLRRDALQGALDLLVQRHETLRTTFVEHDGAPRQVIHPTLPIAIEE--- 1190
Cdd:cd19533      4 LTSAQRGVWFAEQLDPEGSIYNLAEYLEITGPVDLAVLERALRQVIAEAETLRLRFTEEEGEPYQWIDPYTPVPIRHidl 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1191 RRPPVAGEDLKGLVETEAHRPFDLQRGPLLRVLLLPLATDECVLVLTLHHIIADGWSMQVLVDELIRVYAALRHDQPPAL 1270
Cdd:cd19533     84 SGDPDPEGAAQQWMQEDLRKPLPLDNDPLFRHALFTLGDNRHFWYQRVHHIVMDGFSFALFGQRVAEIYTALLKGRPAPP 163

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1271 AELPiQYADFAAWQRQWMDGGERERQLDYWVSRLGGeqpLLELPSDRPRPQQQSHRGRRIGIPLPAELAEALRRLAQAEQ 1350
Cdd:cd19533    164 APFG-SFLDLVEEEQAYRQSERFERDRAFWTEQFED---LPEPVSLARRAPGRSLAFLRRTAELPPELTRTLLEAAEAHG 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1351 GTLFMLLLASFQALLHRYSGQNDIRVGVPIANR-NREETEGLiGFFVNTQVLRAELDGQLPFRELLRQVRQAVVEAQGHQ 1429
Cdd:cd19533    240 ASWPSFFIALVAAYLHRLTGANDVVLGVPVMGRlGAAARQTP-GMVANTLPLRLTVDPQQTFAELVAQVSRELRSLLRHQ 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1430 DLPFEQLVDALQPERSLshAPLFQVMYNHQRDDhRGSRFAsLGELEVEDLAWDVQTaqfDLTLDTYE--SSNGLLAELTY 1507
Cdd:cd19533    319 RYRYEDLRRDLGLTGEL--HPLFGPTVNYMPFD-YGLDFG-GVVGLTHNLSSGPTN---DLSIFVYDrdDESGLRIDFDA 391

                          410       420
                   ....*....|....*....|....*...
gi 2183974163 1508 ATDLFDASSAERIAGHWLNLLRSIVARP 1535
Cdd:cd19533    392 NPALYSGEDLARHQERLLRLLEEAAADP 419

FACL_like_6

cd05922

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ...

543-1007

8.35e-52

Pssm-ID: 341246 [Multi-domain] Cd Length: 457 Bit Score: 191.11 E-value: 8.35e-52

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  543 ALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGA----YVPLDPQYPADRLQYMIDDSGLRLLLSQQSVL 618
Cdd:cd05922      1 LGVSAAASALLEAGGVRGERVVLILPNRFTYIELSFAVAYAGGRlglvFVPLNPTLKESVLRYLVADAGGRIVLADAGAA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  619 AR----LPQS-DGLQSLLLDDLERLVHGYPAenpdLPEAPDSLCYAIYTSGSTGQPKGVMVRHRALTNFVCSIARQPGML 693
Cdd:cd05922     81 DRlrdaLPASpDPGTVLDADGIRAARASAPA----HEVSHEDLALLLYTSGSTGSPKLVRLSHQNLLANARSIAEYLGIT 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  694 ARDRLLSVTTFSFDiFGL-ELYVPLARGASMLLASREQAqdPEALLDLVERQGVTVLQATPATWRMLC----DSERVDLL 768
Cdd:cd05922    157 ADDRALTVLPLSYD-YGLsVLNTHLLRGATLVLTNDGVL--DDAFWEDLREHGATGLAGVPSTYAMLTrlgfDPAKLPSL 233

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  769 RgcTLLCGGEALAEDLAARMRGL--SASTWNLYGPTETTIWSARF---RLGEeaRP-FLGGPLENTALYILDSEMNPCPP 842
Cdd:cd05922    234 R--YLTQAGGRLPQETIARLRELlpGAQVYVMYGQTEATRRMTYLppeRILE--KPgSIGLAIPGGEFEILDDDGTPTPP 309

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  843 GVAGELLIGGDGLARGYHRRPgltaerflpdPFAADGSR---LYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEI 919
Cdd:cd05922    310 GEPGEIVHRGPNVMKGYWNDP----------PYRRKEGRgggVLHTGDLARRDEDGFLFIVGRRDRMIKLFGNRISPTEI 379

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  920 ETRLLEQDSVREAVVVAQPGVAGPTLVayLVPTEAALVDAESARQqelrsalknSLLAVLPDYMVPAHMLLLENLPLTPN 999
Cdd:cd05922    380 EAAARSIGLIIEAAAVGLPDPLGEKLA--LFVTAPDKIDPKDVLR---------SLAERLPPYKVPATVRVVDELPLTAS 448


                   ....*...
gi 2183974163 1000 GKINRKAL 1007
Cdd:cd05922    449 GKVDYAAL 456

E-C_NRPS

Dual Epimerization/Condensation (E/C) domains of nonribosomal peptide synthetases (NRPSs); ...

2638-3012

1.01e-51

Dual Epimerization/Condensation (E/C) domains of nonribosomal peptide synthetases (NRPSs); Dual function Epimerization/Condensation (E/C) domains have both an epimerization and a DCL condensation activity. Dual E/C domains first epimerize the substrate amino acid to produce a D-configuration, then catalyze the condensation between the D-aminoacyl/peptidyl-PCP donor and a L-aminoacyl-PCP acceptor. They are D-specific for the peptidyl donor and L-specific for the aminoacyl acceptor ((D)C(L)); this is in contrast with the standard LCL domains which catalyze peptide bond formation between two L-amino acids, and the restriction of ribosomes to use only L-amino acids. These Dual E/C domains contain an extended His-motif (HHx(N)GD) near the N-terminus of the domain in addition to the standard Condensation (C) domain active site motif (HHxxxD). C domains of nonribosomal peptide synthetases (NRPSs) catalyze peptide bond formation within (usually) large multi-modular enzymatic complexes. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long (with various activities such as antibiotic, antifungal, antitumor and immunosuppression). There are various subtypes of C-domains, these include the DCL-type, LCL-type, starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and heterocyclization (Cyc) domains which catalyze both peptide bond formation and cyclization of Cys, Ser, or Thr residues. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the epimerization (E) domain, the ester-bond forming C-domain, dual E/C domains, and the X-domain.

Pssm-ID: 380466 [Multi-domain] Cd Length: 413 Bit Score: 189.57 E-value: 1.01e-51

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2638 YPLSPMQQGMLFHSLYQQNSGDYINQMRL---DVEGLDpqRFREAWQAALDAHEVLRSGFLWQGaLEKPLQLVRKRVEVP 2714
Cdd:cd19544      2 YPLAPLQEGILFHHLLAEEGDPYLLRSLLafdSRARLD--AFLAALQQVIDRHDILRTAILWEG-LSEPVQVVWRQAELP 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2715 fsVHDWR-DRADLAEALDALAAGEAGLGFELAEAPLLRLVLVR-TGERRHHLIYTNHHILMDGWSNSQLLGEVLQRYRGE 2792
Cdd:cd19544     79 --VEELTlDPGDDALAQLRARFDPRRYRLDLRQAPLLRAHVAEdPANGRWLLLLLFHHLISDHTSLELLLEEIQAILAGR 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2793 T----PSRSdgrYRDYIAWLQRQ-DAGRTEAFWKQRLQRLGEPTLlvPAFAHGVRGAEGHADRYRQ-LDVTTSQRLAEFA 2866
Cdd:cd19544    157 AaalpPPVP---YRNFVAQARLGaSQAEHEAFFREMLGDVDEPTA--PFGLLDVQGDGSDITEARLaLDAELAQRLRAQA 231

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2867 REQKVTLNTLVQAAWLILLQRFTGQDTVAFGATVSGRPAELRGIEEQIGLFINTLPVVASpCPEQPIGDWLQAVQGENLA 2946
Cdd:cd19544    232 RRLGVSPASLFHLAWALVLARCSGRDDVVFGTVLSGRMQGGAGADRALGMFINTLPLRVR-LGGRSVREAVRQTHARLAE 310

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2183974163 2947 LREFEHTPLYDIQRWAG-QVGEALFDNILvfeNY--PVSAALAEETPADMRIDALSNQEQTHYPLTLLV 3012
Cdd:cd19544    311 LLRHEHASLALAQRCSGvPAPTPLFSALL---NYrhSAAAAAAAALAAWEGIELLGGEERTNYPLTLSV 376

PRK07656

long-chain-fatty-acid--CoA ligase; Validated

512-1007

1.20e-51

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 236072 [Multi-domain] Cd Length: 513 Bit Score: 192.43 E-value: 1.20e-51

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  512 VHRLFEAqAGLTPDAPALLFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLD 591
Cdd:PRK07656     8 PELLARA-ARRFGDKEAYVFGDQRLTYAELNARVRRAAAALAALGIGKGDRVAIWAPNSPHWVIAALGALKAGAVVVPLN 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  592 PQYPADRLQYMIDDSGLRLLLSQQSVLArlpqSDGLQSLLLDDLERLVHGYPAENPDLPE-------------------- 651
Cdd:PRK07656    87 TRYTADEAAYILARGDAKALFVLGLFLG----VDYSATTRLPALEHVVICETEEDDPHTEkmktftdflaagdpaerape 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  652 -APDSLCYAIYTSGSTGQPKGVMVRHRALTNFVCSIARQPGMLARDRLLSVTTFsFDIFGLE--LYVPLARGASMLLASR 728
Cdd:PRK07656   163 vDPDDVADILFTSGTTGRPKGAMLTHRQLLSNAADWAEYLGLTEGDRYLAANPF-FHVFGYKagVNAPLMRGATILPLPV 241

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  729 eqaQDPEALLDLVERQGVTVLQATPATWRMLCDSER---VDL--LRGCtlLCGGEALAEDLAARMRglsaSTWNL----- 798
Cdd:PRK07656   242 ---FDPDEVFRLIETERITVLPGPPTMYNSLLQHPDrsaEDLssLRLA--VTGAASMPVALLERFE----SELGVdivlt 312

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  799 -YGPTE----TTIwsarFRLGEEARPF---LGGPLENTALYILDSEMNPCPPGVAGELLIGGDGLARGYHRRPGLTAErf 870
Cdd:PRK07656   313 gYGLSEasgvTTF----NRLDDDRKTVagtIGTAIAGVENKIVNELGEEVPVGEVGELLVRGPNVMKGYYDDPEATAA-- 386

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  871 lpdpfAADGSRLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQP----GVAGptlV 946
Cdd:PRK07656   387 -----AIDADGWLHTGDLGRLDEEGYLYIVDRKKDMFIVGGFNVYPAEVEEVLYEHPAVAEAAVIGVPderlGEVG---K 458

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2183974163  947 AYLVPTEAALVDAES----ARQQelrsalknsllavLPDYMVPAHMLLLENLPLTPNGKINRKAL 1007
Cdd:PRK07656   459 AYVVLKPGAELTEEEliayCREH-------------LAKYKVPRSIEFLDELPKNATGKVLKRAL 510

Firefly_Luc_like

cd05911

Firefly luciferase of light emitting insects and 4-Coumarate-CoA Ligase (4CL); This family ...

536-1003

3.30e-50

Firefly luciferase of light emitting insects and 4-Coumarate-CoA Ligase (4CL); This family contains insect firefly luciferases that share significant sequence similarity to plant 4-coumarate:coenzyme A ligases, despite their functional diversity. Luciferase catalyzes the production of light in the presence of MgATP, molecular oxygen, and luciferin. In the first step, luciferin is activated by acylation of its carboxylate group with ATP, resulting in an enzyme-bound luciferyl adenylate. In the second step, luciferyl adenylate reacts with molecular oxygen, producing an enzyme-bound excited state product (Luc=O*) and releasing AMP. This excited-state product then decays to the ground state (Luc=O), emitting a quantum of visible light.

Pssm-ID: 341237 [Multi-domain] Cd Length: 486 Bit Score: 187.42 E-value: 3.30e-50

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  536 LSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQYMIDDSGLRLLLSQQ 615
Cdd:cd05911     11 LTYAQLRTLSRRLAAGLRKLGLKKGDVVGIISPNSTYYPPVFLGCLFAGGIFSAANPIYTADELAHQLKISKPKVIFTDP 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  616 SVLARL-----------------PQSDGLQSLLLDDLERLVHGYPAENPDLPEAPDSLCYAIYTSGSTGQPKGVMVRHRa 678
Cdd:cd05911     91 DGLEKVkeaakelgpkdkiivldDKPDGVLSIEDLLSPTLGEEDEDLPPPLKDGKDDTAAILYSSGTTGLPKGVCLSHR- 169

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  679 ltNFVCSI-----ARQPGMLARDRLLSVTTFsFDIFGLELYV-PLARGASMLLASReqaQDPEALLDLVERQGVTVLQAT 752
Cdd:cd05911    170 --NLIANLsqvqtFLYGNDGSNDVILGFLPL-YHIYGLFTTLaSLLNGATVIIMPK---FDSELFLDLIEKYKITFLYLV 243

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  753 PATWRMLCDSERVDL-----LRgcTLLCGGEALAEDLAARMRGLSASTW--NLYGPTETTIWSARFRLGEEARPFLGGPL 825
Cdd:cd05911    244 PPIAAALAKSPLLDKydlssLR--VILSGGAPLSKELQELLAKRFPNATikQGYGMTETGGILTVNPDGDDKPGSVGRLL 321

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  826 ENTALYILDSE-MNPCPPGVAGELLIGGDGLARGYHRRPGLTAERFLPDPFaadgsrlYRTGDLARYRADGVIEYLGRID 904
Cdd:cd05911    322 PNVEAKIVDDDgKDSLGPNEPGEICVRGPQVMKGYYNNPEATKETFDEDGW-------LHTGDIGYFDEDGYLYIVDRKK 394

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  905 HQVKIRGFRIELGEIETRLLEQDSVREAVVVAQP-GVAGPTLVAYLVpteaaLVDAESARQQELRsalknsllavlpDYM 983
Cdd:cd05911    395 ELIKYKGFQVAPAELEAVLLEHPGVADAAVIGIPdEVSGELPRAYVV-----RKPGEKLTEKEVK------------DYV 457

                          490       500
                   ....*....|....*....|....*....
gi 2183974163  984 ---VPAHMLL------LENLPLTPNGKIN 1003
Cdd:cd05911    458 akkVASYKQLrggvvfVDEIPKSASGKIL 486

starter-C_NRPS

Starter Condensation domains, found in the first module of nonribosomal peptide synthetases ...

47-477

1.28e-49

Pssm-ID: 380456 [Multi-domain] Cd Length: 419 Bit Score: 183.72 E-value: 1.28e-49

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163   47 RIPLSYAQERQWFLWQMDPQSAAYNIPSALRLRGELDVEALSASLGAIVERHQSLRTVFVEDEqlDGFRQQVLASVDVPV 126
Cdd:cd19533      1 RLPLTSAQRGVWFAEQLDPEGSIYNLAEYLEITGPVDLAVLERALRQVIAEAETLRLRFTEEE--GEPYQWIDPYTPVPI 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  127 PVT-LAGDDDAQAQIRAFVESETQQPFDLRNGPLLRARLLRLAADDHVLTLTIHHVAADGWSMRVLVEELIALYGARRQG 205
Cdd:cd19533     79 RHIdLSGDPDPEGAAQQWMQEDLRKPLPLDNDPLFRHALFTLGDNRHFWYQRVHHIVMDGFSFALFGQRVAEIYTALLKG 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  206 IEATLPDLPiQYADYAIWQRHWLEAGERERQLEYWMARLGGgqsVLELPTDRQRPALPSYRGARHELQLPQALGRQLQAL 285
Cdd:cd19533    159 RPAPPAPFG-SFLDLVEEEQAYRQSERFERDRAFWTEQFED---LPEPVSLARRAPGRSLAFLRRTAELPPELTRTLLEA 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  286 AQREGTTLFMLLLASFQALLHRYSGQDEIRVGVPVANRNRVETERLIGFFVNTQVLRADLDAQMPFLDLLQQTRVAALGA 365
Cdd:cd19533    235 AEAHGASWPSFFIALVAAYLHRLTGANDVVLGVPVMGRLGAAARQTPGMVANTLPLRLTVDPQQTFAELVAQVSRELRSL 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  366 QSHQDLPFEQLVEALQPERSLshSPLFQAMYNHQ----NLGSAGRQSLAAQLPGLSVEDLSwgahsaqfdLTLDTYESEQ 441
Cdd:cd19533    315 LRHQRYRYEDLRRDLGLTGEL--HPLFGPTVNYMpfdyGLDFGGVVGLTHNLSSGPTNDLS---------IFVYDRDDES 383

                          410       420       430
                   ....*....|....*....|....*....|....*.
gi 2183974163  442 GVHAEFTYATDLFEAATVERLARHWRNLLEAVVAEP 477
Cdd:cd19533    384 GLRIDFDANPALYSGEDLARHQERLLRLLEEAAADP 419

BCL_like

cd05919

Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; This family contains benzoate ...

527-1007

1.35e-49

Pssm-ID: 341243 [Multi-domain] Cd Length: 436 Bit Score: 184.20 E-value: 1.35e-49

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  527 PALLFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQYMIDDS 606
Cdd:cd05919      2 TAFYAADRSVTYGQLHDGANRLGSALRNLGVSSGDRVLLLMLDSPELVQLFLGCLARGAIAVVINPLLHPDDYAYIARDC 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  607 GLRLLLSQQsvlarlpqsdglqslllddlerlvhgypaenpdlpeapDSLCYAIYTSGSTGQPKGVMVRHRALTNFVCSI 686
Cdd:cd05919     82 EARLVVTSA--------------------------------------DDIAYLLYSSGTTGPPKGVMHAHRDPLLFADAM 123

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  687 ARQP-GMLARDRLLSVTTFSFDiFGL--ELYVPLARGASMLLASreQAQDPEALLDLVERQGVTVLQATPATWRML---C 760
Cdd:cd05919    124 AREAlGLTPGDRVFSSAKMFFG-YGLgnSLWFPLAVGASAVLNP--GWPTAERVLATLARFRPTVLYGVPTFYANLldsC 200

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  761 DSERVDL--LRGCTllCGGEALAEDLAAR-MRGLSASTWNLYGPTET--TIWSAR---FRLGEearpfLGGPLENTALYI 832
Cdd:cd05919    201 AGSPDALrsLRLCV--SAGEALPRGLGERwMEHFGGPILDGIGATEVghIFLSNRpgaWRLGS-----TGRPVPGYEIRL 273

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  833 LDSEMNPCPPGVAGELLIGGDGLARGYHRRPGLTAERFlpdpfaADGsrLYRTGDLARYRADGVIEYLGRIDHQVKIRGF 912
Cdd:cd05919    274 VDEEGHTIPPGEEGDLLVRGPSAAVGYWNNPEKSRATF------NGG--WYRTGDKFCRDADGWYTHAGRADDMLKVGGQ 345

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  913 RIELGEIETRLLEQDSVREAVVVAQP-GVAGPTLVAYLVPTEaalvdaESARQQELRSALKNSLLAVLPDYMVPAHMLLL 991
Cdd:cd05919    346 WVSPVEVESLIIQHPAVAEAAVVAVPeSTGLSRLTAFVVLKS------PAAPQESLARDIHRHLLERLSAHKVPRRIAFV 419

                          490
                   ....*....|....*.
gi 2183974163  992 ENLPLTPNGKINRKAL 1007
Cdd:cd05919    420 DELPRTATGKLQRFKL 435

FACL_fum10p_like

cd05926

Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; FACL ...

524-1007

6.56e-49

Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; FACL catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, followed by the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions. Fum10p is a fatty acid CoA ligase involved in the synthesis of fumonisin, a polyketide mycotoxin, in Gibberella moniliformis.

Pssm-ID: 341249 [Multi-domain] Cd Length: 493 Bit Score: 183.67 E-value: 6.56e-49

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  524 PDAPALLFGEER--LSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQY 601
Cdd:cd05926      1 PDAPALVVPGSTpaLTYADLAELVDDLARQLAALGIKKGDRVAIALPNGLEFVVAFLAAARAGAVVAPLNPAYKKAEFEF 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  602 MIDDSGLRLLLSQQSVL---ARLPQSDGL--QSLLLDDLERLVHG----YPAENPDLPEA-------PDSLCYAIYTSGS 665
Cdd:cd05926     81 YLADLGSKLVLTPKGELgpaSRAASKLGLaiLELALDVGVLIRAPsaesLSNLLADKKNAksegvplPDDLALILHTSGT 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  666 TGQPKGVMVRHRALTNFVCSIARQPGMLARDRLLSVTTFsFDIFGL--ELYVPLARGASMLLASReqaQDPEALLDLVER 743
Cdd:cd05926    161 TGRPKGVPLTHRNLAASATNITNTYKLTPDDRTLVVMPL-FHVHGLvaSLLSTLAAGGSVVLPPR---FSASTFWPDVRD 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  744 QGVTVLQATPATWRMLCDSE---------RVDLLRGCtllcgGEALAEDLAARM-RGLSASTWNLYGPTETT--IWSARF 811
Cdd:cd05926    237 YNATWYTAVPTIHQILLNRPepnpespppKLRFIRSC-----SASLPPAVLEALeATFGAPVLEAYGMTEAAhqMTSNPL 311

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  812 RLGEEaRPFLGGPLENTALYILDSEMNPCPPGVAGELLIGGDGLARGYHRRPGLTAERFLPDPFaadgsrlYRTGDLARY 891
Cdd:cd05926    312 PPGPR-KPGSVGKPVGVEVRILDEDGEILPPGVVGEICLRGPNVTRGYLNNPEANAEAAFKDGW-------FRTGDLGYL 383

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  892 RADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQPG-VAGPTLVAYLVPTEAALVDAEsarqqelrsA 970
Cdd:cd05926    384 DADGYLFLTGRIKELINRGGEKISPLEVDGVLLSHPAVLEAVAFGVPDeKYGEEVAAAVVLREGASVTEE---------E 454

                          490       500       510
                   ....*....|....*....|....*....|....*..
gi 2183974163  971 LKNSLLAVLPDYMVPAHMLLLENLPLTPNGKINRKAL 1007
Cdd:cd05926    455 LRAFCRKHLAAFKVPKKVYFVDELPKTATGKIQRRKV 491

PRK07787

acyl-CoA synthetase; Validated

1578-2074

2.03e-48

acyl-CoA synthetase; Validated

Pssm-ID: 236096 [Multi-domain] Cd Length: 471 Bit Score: 181.73 E-value: 2.03e-48

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1578 AAERPRATAVVYGERALDYGELNLRANRLAHRLieLGVGPdvlVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRL 1657
Cdd:PRK07787    10 AAAADIADAVRIGGRVLSRSDLAGAATAVAERV--AGARR---VAVLATPTLATVLAVVGALIAGVPVVPVPPDSGVAER 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1658 GYMIEDSGIRLLLTqraarERLPLGEGLPCLLLDAEHE-WAGYPESDPQSAvgvdnlAYVIYTSGSTGKPKGTLLPHGNV 1736
Cdd:PRK07787    85 RHILADSGAQAWLG-----PAPDDPAGLPHVPVRLHARsWHRYPEPDPDAP------ALIVYTSGTTGPPKGVVLSRRAI 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1737 LRLFDATRHWFGFSADD----AWSLFHSYAFdfsVWEIFGALLHGGRLVivpyETSR-SPEDFLRLLcRERVTVLNQTPS 1811
Cdd:PRK07787   154 AADLDALAEAWQWTADDvlvhGLPLFHVHGL---VLGVLGPLRIGNRFV----HTGRpTPEAYAQAL-SEGGTLYFGVPT 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1812 AFKQLmqvacAGQEVPPLAL---RHVVFGGEALEVqalrPWFERFGDRA-PRLVNMYGITETTVHVTYRplslADldgGA 1887
Cdd:PRK07787   226 VWSRI-----AADPEAARALrgaRLLVSGSAALPV----PVFDRLAALTgHRPVERYGMTETLITLSTR----AD---GE 289

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1888 ASP--IGEPIPDLSWYLLDAGLNPVPRG--CIGELYVGGAGLARGYLNRPELSCTRFVADPFsttggrlYRTGDLARYRC 1963
Cdd:PRK07787   290 RRPgwVGLPLAGVETRLVDEDGGPVPHDgeTVGELQVRGPTLFDGYLNRPDATAAAFTADGW-------FRTGDVAVVDP 362

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1964 DGVVEYVGR--IDhQVKIRGFRIELGEIEARLLAQPGVAEAVV--LPHEGPGaTQLVGYVVTqAAPSDPAALRDTLRQAL 2039
Cdd:PRK07787   363 DGMHRIVGResTD-LIKSGGYRIGAGEIETALLGHPGVREAAVvgVPDDDLG-QRIVAYVVG-ADDVAADELIDFVAQQL 439

                          490       500       510
                   ....*....|....*....|....*....|....*
gi 2183974163 2040 KAslpeHMVPAHLLFLERLPLTANGKLDRRALPAP 2074
Cdd:PRK07787   440 SV----HKRPREVRFVDALPRNAMGKVLKKQLLSE 470

MACS_like

cd05972

Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step activation of ...

1596-2071

2.71e-48

Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. The acyl-CoA is a key intermediate in many important biosynthetic and catabolic processes.

Pssm-ID: 341276 [Multi-domain] Cd Length: 428 Bit Score: 179.84 E-value: 2.71e-48

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1596 YGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGYMIEDSGIRLLLTQraa 1675
Cdd:cd05972      3 FRELKRESAKAANVLAKLGLRKGDRVAVLLPRVPELWAVILAVIKLGAVYVPLTTLLGPKDIEYRLEAAGAKAIVTD--- 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1676 rerlplgeglpcllldaehewagypESDPqsavgvdnlAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRHWFGFSADD-- 1753
Cdd:cd05972     80 -------------------------AEDP---------ALIYFTSGTTGLPKGVLHTHSYPLGHIPTAAYWLGLRPDDih 125

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1754 ------AWSLFHSYAFdfsvweiFGALLHGGRlVIVPYETSRSPEDFLRLLCRERVTVLNQTPSAFKQLMQVACAGQEvp 1827
Cdd:cd05972    126 wniadpGWAKGAWSSF-------FGPWLLGAT-VFVYEGPRFDAERILELLERYGVTSFCGPPTAYRMLIKQDLSSYK-- 195

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1828 PLALRHVVFGGEALEVQALRPWFERFGdraPRLVNMYGITETTvhvtyrpLSLADLDGGAASP--IGEPIPDLSWYLLDA 1905
Cdd:cd05972    196 FSHLRLVVSAGEPLNPEVIEWWRAATG---LPIRDGYGQTETG-------LTVGNFPDMPVKPgsMGRPTPGYDVAIIDD 265

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1906 GLNPVPRGCIGELYV--GGAGLARGYLNRPELSCTRFVADpfsttggrLYRTGDLARYRCDGVVEYVGRIDHQVKIRGFR 1983
Cdd:cd05972    266 DGRELPPGEEGDIAIklPPPGLFLGYVGDPEKTEASIRGD--------YYLTGDRAYRDEDGYFWFVGRADDIIKSSGYR 337

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1984 IELGEIEARLLAQPGVAEAVVLPHEGPGATQLV-GYVVTQAAPSDPAALRDTLRQALKASLPEHMVPAHLLFLERLPLTA 2062
Cdd:cd05972    338 IGPFEVESALLEHPAVAEAAVVGSPDPVRGEVVkAFVVLTSGYEPSEELAEELQGHVKKVLAPYKYPREIEFVEELPKTI 417


                   ....*....
gi 2183974163 2063 NGKLDRRAL 2071
Cdd:cd05972    418 SGKIRRVEL 426

MACS_like_4

cd05969

Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); This family is most ...

1596-2075

1.27e-47

Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); This family is most similar to acetyl-CoA synthetase. Acetyl-CoA synthetase (ACS) catalyzes the formation of acetyl-CoA from acetate, CoA, and ATP. Synthesis of acetyl-CoA is carried out in a two-step reaction. In the first step, the enzyme catalyzes the synthesis of acetyl-AMP intermediate from acetate and ATP. In the second step, acetyl-AMP reacts with CoA to produce acetyl-CoA. This enzyme is only present in bacteria.

Pssm-ID: 341273 [Multi-domain] Cd Length: 442 Bit Score: 178.46 E-value: 1.27e-47

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1596 YGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGYMIEDSGIRLLLTQRAA 1675
Cdd:cd05969      3 FAQLKVLSARFANVLKSLGVGKGDRVFVLSPRSPELYFSMLGIGKIGAVICPLFSAFGPEAIRDRLENSEAKVLITTEEL 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1676 RERLPlgeglpcllldaehewagyPEsDPqsavgvdnlAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRHWFGFSADD-- 1753
Cdd:cd05969     83 YERTD-------------------PE-DP---------TLLHYTSGTTGTPKGVLHVHDAMIFYYFTGKYVLDLHPDDiy 133

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1754 ------AWSLFHSYAfdfsvweIFGALLHGGRLVIvpYETSRSPEDFLRLLCRERVTVLNQTPSAFKQLMQVACAGQEVP 1827
Cdd:cd05969    134 wctadpGWVTGTVYG-------IWAPWLNGVTNVV--YEGRFDAESWYGIIERVKVTVWYTAPTAIRMLMKEGDELARKY 204

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1828 PL-ALRHVVFGGEALEVQALRPWFERFGdraPRLVNMYGITETTVHVtyrplsLADLDGGAASP--IGEPIPDLSWYLLD 1904
Cdd:cd05969    205 DLsSLRFIHSVGEPLNPEAIRWGMEVFG---VPIHDTWWQTETGSIM------IANYPCMPIKPgsMGKPLPGVKAAVVD 275

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1905 AGLNPVPRGCIGELYV--GGAGLARGYLNRPELSCTRFVadpfsttgGRLYRTGDLARYRCDGVVEYVGRIDHQVKIRGF 1982
Cdd:cd05969    276 ENGNELPPGTKGILALkpGWPSMFRGIWNDEERYKNSFI--------DGWYLTGDLAYRDEDGYFWFVGRADDIIKTSGH 347

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1983 RIELGEIEARLLAQPGVAEAVVLPHEGPGATQLV-GYVVTQAAPSDPAALRDTLRQALKASLPEHMVPAHLLFLERLPLT 2061
Cdd:cd05969    348 RVGPFEVESALMEHPAVAEAGVIGKPDPLRGEIIkAFISLKEGFEPSDELKEEIINFVRQKLGAHVAPREIEFVDNLPKT 427

                          490
                   ....*....|....
gi 2183974163 2062 ANGKLDRRALPAPD 2075
Cdd:cd05969    428 RSGKIMRRVLKAKE 441

FACL_DitJ_like

cd05934

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ...

533-1008

6.26e-47

Pssm-ID: 341257 [Multi-domain] Cd Length: 422 Bit Score: 175.94 E-value: 6.26e-47

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  533 EERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQYMIDDSGLRLLL 612
Cdd:cd05934      1 GRRWTYAELLRESARIAAALAALGIRPGDRVALMLDNCPEFLFAWFALAKLGAVLVPINTALRGDELAYIIDHSGAQLVV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  613 SqqsvlarlpqsdglqslllddlerlvhgypaenpdlpeapdSLCYAIYTSGSTGQPKGVMVRHRALTNFVCSIARQPGM 692
Cdd:cd05934     81 V-----------------------------------------DPASILYTSGTTGPPKGVVITHANLTFAGYYSARRFGL 119

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  693 LARDRLLSVT-TFSFDIFGLELYVPLARGASMLLASREQAQdpeALLDLVERQGVTVLQATPATWRMLC-----DSERVD 766
Cdd:cd05934    120 GEDDVYLTVLpLFHINAQAVSVLAALSVGATLVLLPRFSAS---RFWSDVRRYGATVTNYLGAMLSYLLaqppsPDDRAH 196

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  767 LLRGCtllCGGEALAEDLAARMRGLSASTWNLYGPTETT--IWSARfrlGEEARPF---LGGPLENTAlyILDSEMNPCP 841
Cdd:cd05934    197 RLRAA---YGAPNPPELHEEFEERFGVRLLEGYGMTETIvgVIGPR---DEPRRPGsigRPAPGYEVR--IVDDDGQELP 268

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  842 PGVAGELLI---GGDGLARGYHRRPGLTAERFlpdpfaADGsrLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGE 918
Cdd:cd05934    269 AGEPGELVIrglRGWGFFKGYYNMPEATAEAM------RNG--WFHTGDLGYRDADGFFYFVDRKKDMIRRRGENISSAE 340

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  919 IETRLLEQDSVREAVVVAQPG-VAGPTLVAYLVPTEAALVDAEsarqqELRSALKNSllavLPDYMVPAHMLLLENLPLT 997
Cdd:cd05934    341 VERAILRHPAVREAAVVAVPDeVGEDEVKAVVVLRPGETLDPE-----ELFAFCEGQ----LAYFKVPRYIRFVDDLPKT 411

                          490
                   ....*....|.
gi 2183974163  998 PNGKINRKALP 1008
Cdd:cd05934    412 PTEKVAKAQLR 422

Firefly_Luc_like

cd05911

Firefly luciferase of light emitting insects and 4-Coumarate-CoA Ligase (4CL); This family ...

1592-2066

1.16e-46

Pssm-ID: 341237 [Multi-domain] Cd Length: 486 Bit Score: 177.02 E-value: 1.16e-46

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1592 RALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGYMIEDSGIRLLLT 1671
Cdd:cd05911      9 KELTYAQLRTLSRRLAAGLRKLGLKKGDVVGIISPNSTYYPPVFLGCLFAGGIFSAANPIYTADELAHQLKISKPKVIFT 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1672 --------QRAARErlpLGEGLPCLLLDAEHEWAGYPESDPQSAVGV-------------DNLAYVIYTSGSTGKPKGTL 1730
Cdd:cd05911     89 dpdglekvKEAAKE---LGPKDKIIVLDDKPDGVLSIEDLLSPTLGEededlppplkdgkDDTAAILYSSGTTGLPKGVC 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1731 LPHGNVL-RLFDATRHWFG-FSADDAW----SLFHSYAFdfsvWEIFGALLHGGRLVIvpyeTSR-SPEDFLRLLCRERV 1803
Cdd:cd05911    166 LSHRNLIaNLSQVQTFLYGnDGSNDVIlgflPLYHIYGL----FTTLASLLNGATVII----MPKfDSELFLDLIEKYKI 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1804 TVLNQTPSafkqlmqVACAGQEVPPLA------LRHVVFGGEAL--EVQalrpwfERFGDRAP--RLVNMYGITETTVHV 1873
Cdd:cd05911    238 TFLYLVPP-------IAAALAKSPLLDkydlssLRVILSGGAPLskELQ------ELLAKRFPnaTIKQGYGMTETGGIL 304

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1874 TYRPLSlaDLDGGAAspiGEPIPDLSWYLLD-AGLNPVPRGCIGELYVGGAGLARGYLNRPELSCTRFVADPFsttggrl 1952
Cdd:cd05911    305 TVNPDG--DDKPGSV---GRLLPNVEAKIVDdDGKDSLGPNEPGEICVRGPQVMKGYYNNPEATKETFDEDGW------- 372

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1953 YRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVV--LPH----EGPGAtqlvgYVVTQAAPS 2026
Cdd:cd05911    373 LHTGDIGYFDEDGYLYIVDRKKELIKYKGFQVAPAELEAVLLEHPGVADAAVigIPDevsgELPRA-----YVVRKPGEK 447

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*.
gi 2183974163 2027 DPAA-LRDTLRQalkaslpeHMVPAHLL-----FLERLPLTANGKL 2066
Cdd:cd05911    448 LTEKeVKDYVAK--------KVASYKQLrggvvFVDEIPKSASGKI 485

MACS_like_3

cd05971

Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the ...

1596-2071

4.18e-46

Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. MACS enzymes are localized to mitochondria.

Pssm-ID: 341275 [Multi-domain] Cd Length: 439 Bit Score: 173.77 E-value: 4.18e-46

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1596 YGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGYMIEDSGIRLLLTQraa 1675
Cdd:cd05971      9 FKELKTASNRFANVLKEIGLEKGDRVGVFLSQGPECAIAHIAILRSGAIAVPLFALFGPEALEYRLSNSGASALVTD--- 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1676 rerlplgeglpcllldaehewagypesdpqsavGVDNLAYVIYTSGSTGKPKGTLLPH----GNV------LRLFDATRH 1745
Cdd:cd05971     86 ---------------------------------GSDDPALIIYTSGTTGPPKGALHAHrvllGHLpgvqfpFNLFPRDGD 132

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1746 WFGFSADDAW--SLFHSyafdfsvweIFGALLHGgrLVIVPYETSR-SPEDFLRLLCRERVTVLNQTPSAFKqLMQVACA 1822
Cdd:cd05971    133 LYWTPADWAWigGLLDV---------LLPSLYFG--VPVLAHRMTKfDPKAALDLMSRYGVTTAFLPPTALK-MMRQQGE 200

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1823 GQEVPPLALRHVVFGGEALEVQALRPWFERFGDRAPRLvnmYGITETTVhVTYRPLSLADLDGGAaspIGEPIPDLSWYL 1902
Cdd:cd05971    201 QLKHAQVKLRAIATGGESLGEELLGWAREQFGVEVNEF---YGQTECNL-VIGNCSALFPIKPGS---MGKPIPGHRVAI 273

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1903 LDAGLNPVPRGCIGELYV--GGAGLARGYLNRPELSCTRFVADPFsttggrlyRTGDLARYRCDGVVEYVGRIDHQVKIR 1980
Cdd:cd05971    274 VDDNGTPLPPGEVGEIAVelPDPVAFLGYWNNPSATEKKMAGDWL--------LTGDLGRKDSDGYFWYVGRDDDVITSS 345

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1981 GFRIELGEIEARLLAQPGVAEAVVLPHEGPGATQLV-GYVVTQAAPSDPAALRDTLRQALKASLPEHMVPAHLLFLERLP 2059
Cdd:cd05971    346 GYRIGPAEIEECLLKHPAVLMAAVVGIPDPIRGEIVkAFVVLNPGETPSDALAREIQELVKTRLAAHEYPREIEFVNELP 425

                          490
                   ....*....|..
gi 2183974163 2060 LTANGKLDRRAL 2071
Cdd:cd05971    426 RTATGKIRRREL 437

EntE

COG1021

EntE, 2,3-dihydroxybenzoate-AMP synthase component of non-ribosomal peptide synthetase ...

1570-2071

7.17e-46

EntE, 2,3-dihydroxybenzoate-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism];

Pssm-ID: 440644 [Multi-domain] Cd Length: 533 Bit Score: 175.72 E-value: 7.17e-46

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1570 LHRLIERQAAERPRATAVVYGERALDYGELNLRANRLAHRLIELGVGPD--VLVGLAaeRSLEMIVGLLAILKAGGAYVP 1647
Cdd:COG1021     27 LGDLLRRRAERHPDRIAVVDGERRLSYAELDRRADRLAAGLLALGLRPGdrVVVQLP--NVAEFVIVFFALFRAGAIPVF 104

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1648 LdprYPSDR---LGYMIEDSGIRLLLTQRAA------------RERLP-------LGEGLPCLLLDAeheWAGYPESDPQ 1705
Cdd:COG1021    105 A---LPAHRraeISHFAEQSEAVAYIIPDRHrgfdyralarelQAEVPslrhvlvVGDAGEFTSLDA---LLAAPADLSE 178

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1706 SAVGVDNLAYVIYTSGSTGKPKgtLLP--HG----NVLRLFDATrhwfGFSADDAW--SLFHSYAFDFSVWEIFGALLHG 1777
Cdd:COG1021    179 PRPDPDDVAFFQLSGGTTGLPK--LIPrtHDdylySVRASAEIC----GLDADTVYlaALPAAHNFPLSSPGVLGVLYAG 252

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1778 GRLVIVPyetSRSPEDFLRLLCRERVTVLNQTPSAFKQLMQvACAGQEVPPLALRHVVFGGEALEVQALRPWFERFGdra 1857
Cdd:COG1021    253 GTVVLAP---DPSPDTAFPLIERERVTVTALVPPLALLWLD-AAERSRYDLSSLRVLQVGGAKLSPELARRVRPALG--- 325

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1858 PRLVNMYGITETTVHVTyrplSLADLDGGAASPIGEPI-PDLSWYLLDAGLNPVPRGCIGELYVGGAGLARGYLNRPELS 1936
Cdd:COG1021    326 CTLQQVFGMAEGLVNYT----RLDDPEEVILTTQGRPIsPDDEVRIVDEDGNPVPPGEVGELLTRGPYTIRGYYRAPEHN 401

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1937 CTRFVADPFsttggrlYRTGDLARYRCDGVVEYVGRIDHQVkIR-GFRIELGEIEARLLAQPGVAEAVV--LPHEgpgat 2013
Cdd:COG1021    402 ARAFTPDGF-------YRTGDLVRRTPDGYLVVEGRAKDQI-NRgGEKIAAEEVENLLLAHPAVHDAAVvaMPDE----- 468

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2183974163 2014 qLVG-----YVVTQAAPSDPAALRDTLRQalkASLPEHMVPAHLLFLERLPLTANGKLDRRAL 2071
Cdd:COG1021    469 -YLGerscaFVVPRGEPLTLAELRRFLRE---RGLAAFKLPDRLEFVDALPLTAVGKIDKKAL 527

23DHB-AMP_lg

cd05920

2,3-dihydroxybenzoate-AMP ligase; 2,3-dihydroxybenzoate-AMP ligase activates 2, ...

1570-2071

1.83e-45

2,3-dihydroxybenzoate-AMP ligase; 2,3-dihydroxybenzoate-AMP ligase activates 2,3-dihydroxybenzoate (DHB) by ligation of AMP from ATP with the release of pyrophosphate. However, it can also catalyze the ATP-PPi exchange for 2,3-DHB analogs, such as salicyclic acid (o-hydrobenzoate), as well as 2,4-DHB and 2,5-DHB, but with less efficiency. Proteins in this family are the stand-alone adenylation components of non-ribosomal peptide synthases (NRPSs) involved in the biosynthesis of siderophores, which are low molecular weight iron-chelating compounds synthesized by many bacteria to aid in the acquisition of this vital trace elements. In Escherichia coli, the 2,3-dihydroxybenzoate-AMP ligase is called EntE, the adenylation component of the enterobactin NRPS system.

Pssm-ID: 341244 [Multi-domain] Cd Length: 482 Bit Score: 173.28 E-value: 1.83e-45

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1570 LHRLIERQAAERPRATAVVYGERALDYGELNLRANRLAHRLIELGVGP--DVLVGLAaeRSLEMIVGLLAILKAGGAYVP 1647
Cdd:cd05920     17 LGDLLARSAARHPDRIAVVDGDRRLTYRELDRRADRLAAGLRGLGIRPgdRVVVQLP--NVAEFVVLFFALLRLGAVPVL 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1648 LDPRYPSDRLGYMIEDSGIRLLLTQRaarerlplgeglpcllldaEHEWAGYPESDPQSAVGVDNLAYVIYTSGSTGKPK 1727
Cdd:cd05920     95 ALPSHRRSELSAFCAHAEAVAYIVPD-------------------RHAGFDHRALARELAESIPEVALFLLSGGTTGTPK 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1728 gtLLP--HGNVLRLFDATRHWFGFSADDAW----SLFHSYAFdfSVWEIFGALLHGGRLVIVPyetSRSPEDFLRLLCRE 1801
Cdd:cd05920    156 --LIPrtHNDYAYNVRASAEVCGLDQDTVYlavlPAAHNFPL--ACPGVLGTLLAGGRVVLAP---DPSPDAAFPLIERE 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1802 RVTVLNQTPSAFKQLMQvACAGQEVPPLALRHVVFGGEALEVQALRPWFERFGdraPRLVNMYGITETTVHVTyrplSLA 1881
Cdd:cd05920    229 GVTVTALVPALVSLWLD-AAASRRADLSSLRLLQVGGARLSPALARRVPPVLG---CTLQQVFGMAEGLLNYT----RLD 300

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1882 DLDGGAASPIGEPI-PDLSWYLLDAGLNPVPRGCIGELYVGGAGLARGYLNRPELSCTRFVADPFsttggrlYRTGDLAR 1960
Cdd:cd05920    301 DPDEVIIHTQGRPMsPDDEIRVVDEEGNPVPPGEEGELLTRGPYTIRGYYRAPEHNARAFTPDGF-------YRTGDLVR 373

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1961 YRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGV--AEAVVLPHEGPGATQLVGYVVTQAAPSdPAALRDTLRQa 2038
Cdd:cd05920    374 RTPDGYLVVEGRIKDQINRGGEKIAAEEVENLLLRHPAVhdAAVVAMPDELLGERSCAFVVLRDPPPS-AAQLRRFLRE- 451

                          490       500       510
                   ....*....|....*....|....*....|...
gi 2183974163 2039 lkASLPEHMVPAHLLFLERLPLTANGKLDRRAL 2071
Cdd:cd05920    452 --RGLAAYKLPDRIEFVDSLPLTAVGKIDKKAL 482

MACS_like

cd05972

Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step activation of ...

536-1007

6.00e-45

Pssm-ID: 341276 [Multi-domain] Cd Length: 428 Bit Score: 170.21 E-value: 6.00e-45

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  536 LSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQYMIDDSGLRLLLSQQ 615
Cdd:cd05972      1 WSFRELKRESAKAANVLAKLGLRKGDRVAVLLPRVPELWAVILAVIKLGAVYVPLTTLLGPKDIEYRLEAAGAKAIVTDA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  616 svlarlpqsdglqslllddlerlvhgypaenpdlpeapDSLCYAIYTSGSTGQPKGVMVRHRALTNFVCSIARQPGMLAR 695
Cdd:cd05972     81 --------------------------------------EDPALIYFTSGTTGLPKGVLHTHSYPLGHIPTAAYWLGLRPD 122

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  696 DRLLSV------TTFSFDIFGlelyvPLARGASMLLASREQAqDPEALLDLVERQGVTVLQATPATWRMLC--DSERVDL 767
Cdd:cd05972    123 DIHWNIadpgwaKGAWSSFFG-----PWLLGATVFVYEGPRF-DAERILELLERYGVTSFCGPPTAYRMLIkqDLSSYKF 196

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  768 LRGCTLLCGGEALAEDLAARMRG-LSASTWNLYGPTETTIWSARFRlGEEARP-FLGGPLENTALYILDSEMNPCPPGVA 845
Cdd:cd05972    197 SHLRLVVSAGEPLNPEVIEWWRAaTGLPIRDGYGQTETGLTVGNFP-DMPVKPgSMGRPTPGYDVAIIDDDGRELPPGEE 275

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  846 GEL--LIGGDGLARGYHRRPGLTAERFLPDpfaadgsrLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRL 923
Cdd:cd05972    276 GDIaiKLPPPGLFLGYVGDPEKTEASIRGD--------YYLTGDRAYRDEDGYFWFVGRADDIIKSSGYRIGPFEVESAL 347

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  924 LEQDSVREAVVVAQPG-VAGPTLVAYLVPTEAALvdaesaRQQELRSALKNSLLAVLPDYMVPAHMLLLENLPLTPNGKI 1002
Cdd:cd05972    348 LEHPAVAEAAVVGSPDpVRGEVVKAFVVLTSGYE------PSEELAEELQGHVKKVLAPYKYPREIEFVEELPKTISGKI 421


                   ....*
gi 2183974163 1003 NRKAL 1007
Cdd:cd05972    422 RRVEL 426

LCL_NRPS-like

LCL-type Condensation (C) domain of non-ribosomal peptide synthetases(NRPSs) and similar ...

2638-3035

7.93e-45

Pssm-ID: 380454 [Multi-domain] Cd Length: 427 Bit Score: 169.84 E-value: 7.93e-45

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2638 YPLSPMQQGMLFHSLYQQNSGDYINQMRLDVEG-LDPQRFREAWQAALDAHEVLRSGFLWQGalEKPLQLVRKRVEVPFS 2716
Cdd:cd19531      2 LPLSFAQQRLWFLDQLEPGSAAYNIPGALRLRGpLDVAALERALNELVARHEALRTTFVEVD--GEPVQVILPPLPLPLP 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2717 VHDWRDRADLAEALDALA--AGEAGLGFELAEAPLLRLVLVRTGERRHHLIYTNHHILMDGWSNSQLLGEVLQRYRGETP 2794
Cdd:cd19531     80 VVDLSGLPEAEREAEAQRlaREEARRPFDLARGPLLRATLLRLGEDEHVLLLTMHHIVSDGWSMGVLLRELAALYAAFLA 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2795 SRSDG------RYRDYIAWlQRQ--DAGRTE---AFWKQRLQrlGEPTLLV-------PAfahgVRGAEGhaDRYR-QLD 2855
Cdd:cd19531    160 GRPSPlpplpiQYADYAVW-QREwlQGEVLErqlAYWREQLA--GAPPVLElptdrprPA----VQSFRG--ARVRfTLP 230

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2856 VTTSQRLAEFAREQKVTLNTLVQAAWLILLQRFTGQDTVAFGATVSGRP-AELrgiEEQIGLFINTLPVVASPCPEQPIG 2934
Cdd:cd19531    231 AELTAALRALARREGATLFMTLLAAFQVLLHRYSGQDDIVVGTPVAGRNrAEL---EGLIGFFVNTLVLRTDLSGDPTFR 307

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2935 DWLQAVQGENL---------------AL---REFEHTPLYdiqrwagQVgealfdnILVFENYPVSAALAeetpADMRID 2996
Cdd:cd19531    308 ELLARVRETALeayahqdlpfeklveALqpeRDLSRSPLF-------QV-------MFVLQNAPAAALEL----PGLTVE 369

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|.
gi 2183974163 2997 ALSNQEQT-HYPLTLLVS-AGETLELHYSYSRQAFDEAAIE 3035
Cdd:cd19531    370 PLEVDSGTaKFDLTLSLTeTDGGLRGSLEYNTDLFDAATIE 410

entF

enterobactin non-ribosomal peptide synthetase EntF;

2748-3181

8.22e-45

enterobactin non-ribosomal peptide synthetase EntF;

Pssm-ID: 236668 [Multi-domain] Cd Length: 1296 Bit Score: 179.85 E-value: 8.22e-45

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2748 PLLRLVLVRTGERRHHLIYTNHHILMDGWSNSQLLGEVLQRYRG-----ETPSRSDGRYRDYIAWLQRQDAG----RTEA 2818
Cdd:PRK10252   119 PLVFHQLIQLGDNRWYWYQRYHHLLVDGFSFPAITRRIAAIYCAwlrgePTPASPFTPFADVVEEYQRYRASeawqRDAA 198

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2819 FWKQRLQRLGEPTLLVPAFAHGVRGAEGHADRYRQLDVTTSQRLAEFAREQKVT--LNTLVqAAWLillQRFTGQDTVAF 2896
Cdd:PRK10252   199 FWAEQRRQLPPPASLSPAPLPGRSASADILRLKLEFTDGAFRQLAAQASGVQRPdlALALV-ALWL---GRLCGRMDYAA 274

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2897 GATVSGR--PAELRGIeeqiGLFINTLPVVASPCPEQPIGDWLQAVQGEnlaLREFEHTPLYD---IQRWAGQVG--EAL 2969
Cdd:PRK10252   275 GFIFMRRlgSAALTAT----GPVLNVLPLRVHIAAQETLPELATRLAAQ---LKKMRRHQRYDaeqIVRDSGRAAgdEPL 347

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2970 FD---NILVFEnYPVsaalaeetpadmRIDALsnQEQTHY---------PLTLLVSAGETLELHYSYSRQAFDEAAIECL 3037
Cdd:PRK10252   348 FGpvlNIKVFD-YQL------------DFPGV--QAQTHTlatgpvndlELALFPDEHGGLSIEILANPQRYDEATLIAH 412

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3038 AERLERLLLGMCENPGASLGELDSLAVAErYQLLEGWNATAAEYPLQRgVHRLFEEQVERTPTAPALAFGEERLDYAELN 3117
Cdd:PRK10252   413 AERLKALIAQFAADPALLCGDVDILLPGE-YAQLAQVNATAVEIPETT-LSALVAQQAAKTPDAPALADARYQFSYREMR 490

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2183974163 3118 RRANRLAHALIERGIGADRLVGVAMERSIEMVVALMAILKAGGAYVPVDPEYPEERQAYMLEDS 3181
Cdd:PRK10252   491 EQVVALANLLRERGVKPGDSVAVALPRSVFLTLALHAIVEAGAAWLPLDTGYPDDRLKMMLEDA 554

FACL_fum10p_like

cd05926

Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; FACL ...

1593-2071

1.49e-44

Pssm-ID: 341249 [Multi-domain] Cd Length: 493 Bit Score: 170.96 E-value: 1.49e-44

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1593 ALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGYMIEDSGIRLLLTQ 1672
Cdd:cd05926     14 ALTYADLAELVDDLARQLAALGIKKGDRVAIALPNGLEFVVAFLAAARAGAVVAPLNPAYKKAEFEFYLADLGSKLVLTP 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1673 RAarERLPLGEGLP---CLLLDAEHEWAGYPESDPQSAVGV----------------DNLAYVIYTSGSTGKPKGTLLPH 1733
Cdd:cd05926     94 KG--ELGPASRAASklgLAILELALDVGVLIRAPSAESLSNlladkknaksegvplpDDLALILHTSGTTGRPKGVPLTH 171

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1734 GNVLRlfdATRH---WFGFSADDA----WSLFHSYAfdfsvweIFGALL----HGGRLVIVPyetSRSPEDFLRLLCRER 1802
Cdd:cd05926    172 RNLAA---SATNitnTYKLTPDDRtlvvMPLFHVHG-------LVASLLstlaAGGSVVLPP---RFSASTFWPDVRDYN 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1803 VTVLNQTPSAFKQLMQVACAGQEVPPLALRHVVFGGEALEVQALRPWFERFGdrAPrLVNMYGITETTVHVTYRPlslad 1882
Cdd:cd05926    239 ATWYTAVPTIHQILLNRPEPNPESPPPKLRFIRSCSASLPPAVLEALEATFG--AP-VLEAYGMTEAAHQMTSNP----- 310

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1883 LDGGAASP--IGEPI-PDLSwyLLDAGLNPVPRGCIGELYVGGAGLARGYLNRPELSCTRFVADPFsttggrlYRTGDLA 1959
Cdd:cd05926    311 LPPGPRKPgsVGKPVgVEVR--ILDEDGEILPPGVVGEICLRGPNVTRGYLNNPEANAEAAFKDGW-------FRTGDLG 381

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1960 RYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVV--LPHEGPGatQLVGYVVTQAApsDPAALRDTLRQ 2037
Cdd:cd05926    382 YLDADGYLFLTGRIKELINRGGEKISPLEVDGVLLSHPAVLEAVAfgVPDEKYG--EEVAAAVVLRE--GASVTEEELRA 457

                          490       500       510
                   ....*....|....*....|....*....|....
gi 2183974163 2038 ALKASLPEHMVPAHLLFLERLPLTANGKLDRRAL 2071
Cdd:cd05926    458 FCRKHLAAFKVPKKVYFVDELPKTATGKIQRRKV 491

C_NRPS-like

Condensation domain of nonribosomal peptide synthetases (NRPSs); Condensation (C) domains of ...

2637-3035

2.46e-44

Pssm-ID: 380453 [Multi-domain] Cd Length: 427 Bit Score: 168.36 E-value: 2.46e-44

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2637 LYPLSPMQQGMLFHSLYQQNSGDYINQMRLDVEG-LDPQRFREAWQAALDAHEVLRSGFLwQGAlEKPLQLVRKRVEVP- 2714
Cdd:cd19066      1 KIPLSPMQRGMWFLKKLATDPSAFNVAIEMFLTGsLDLARLKQALDAVMERHDVLRTRFC-EEA-GRYEQVVLDKTVRFr 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2715 FSVHDWRDRADLAEALDALAAGEAGLGFELAEAPLLRLVLVRTGERRHHLIYTNHHILMDGWSNSQLLGEVLQRYRG--- 2791
Cdd:cd19066     79 IEIIDLRNLADPEARLLELIDQIQQTIYDLERGPLVRVALFRLADERDVLVVAIHHIIVDGGSFQILFEDISSVYDAaer 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2792 --ETPSRSDGRYRDYIAWLQRQ----DAGRTEAFWKQRLQRLGEPTLLVPAFAHG-VRGAEGHADRYRqLDVTTSQRLAE 2864
Cdd:cd19066    159 qkPTLPPPVGSYADYAAWLEKQleseAAQADLAYWTSYLHGLPPPLPLPKAKRPSqVASYEVLTLEFF-LRSEETKRLRE 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2865 FAREQKVTLNTLVQAAWLILLQRFTGQDTVAFGATVSGRPAElrGIEEQIGLFINTLPVVASPCPEQPIGDWLQAVQGEN 2944
Cdd:cd19066    238 VARESGTTPTQLLLAAFALALKRLTASIDVVIGLTFLNRPDE--AVEDTIGLFLNLLPLRIDTSPDATFPELLKRTKEQS 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2945 LALREFEHTPLYDIQRWAGQVGEA----LFDNILVFENYPVSAALAEETPADMRIDALSnqEQTHYPLTLLVSAGET--L 3018
Cdd:cd19066    316 REAIEHQRVPFIELVRHLGVVPEApkhpLFEPVFTFKNNQQQLGKTGGFIFTTPVYTSS--EGTVFDLDLEASEDPDgdL 393

                          410
                   ....*....|....*..
gi 2183974163 3019 ELHYSYSRQAFDEAAIE 3035
Cdd:cd19066    394 LLRLEYSRGVYDERTID 410

BCL_4HBCL

cd05959

Benzoate CoA ligase (BCL) and 4-Hydroxybenzoate-Coenzyme A Ligase (4-HBA-CoA ligase); Benzoate ...

520-1007

2.73e-44

Pssm-ID: 341269 [Multi-domain] Cd Length: 508 Bit Score: 170.24 E-value: 2.73e-44

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  520 AGLTPDAPALLFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRL 599
Cdd:cd05959     14 NEGRGDKTAFIDDAGSLTYAELEAEARRVAGALRALGVKREERVLLIMLDTVDFPTAFLGAIRAGIVPVPVNTLLTPDDY 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  600 QYMIDDSGLRLLLSQQSVLARLPQSDGLQSLLL---------------DDLERLVhgyPAENPDLPEA---PDSLCYAIY 661
Cdd:cd05959     94 AYYLEDSRARVVVVSGELAPVLAAALTKSEHTLvvlivsggagpeagaLLLAELV---AAEAEQLKPAathADDPAFWLY 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  662 TSGSTGQPKGVMVRHRALTnFVCSIARQP--GMLARDRLLSVTTFSFDI-FGLELYVPLARGASMLLASREQAqdPEALL 738
Cdd:cd05959    171 SSGSTGRPKGVVHLHADIY-WTAELYARNvlGIREDDVCFSAAKLFFAYgLGNSLTFPLSVGATTVLMPERPT--PAAVF 247

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  739 DLVERQGVTVLQATPATWRMLCDSERV-----DLLRGCTllCGGEALAEDLAARMRGLSAST-WNLYGPTET-----TIW 807
Cdd:cd05959    248 KRIRRYRPTVFFGVPTLYAAMLAAPNLpsrdlSSLRLCV--SAGEALPAEVGERWKARFGLDiLDGIGSTEMlhiflSNR 325

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  808 SARFRLGEEARPFLGGPLEntalyILDSEMNPCPPGVAGELLIGGDGLARGYHRRPGLTAERFLpdpfaadGSrLYRTGD 887
Cdd:cd05959    326 PGRVRYGTTGKPVPGYEVE-----LRDEDGGDVADGEPGELYVRGPSSATMYWNNRDKTRDTFQ-------GE-WTRTGD 392

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  888 LARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQPGVAGPT-LVAYLVPTEAALVDAESARqqE 966
Cdd:cd05959    393 KYVRDDDGFYTYAGRADDMLKVSGIWVSPFEVESALVQHPAVLEAAVVGVEDEDGLTkPKAFVVLRPGYEDSEALEE--E 470

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|.
gi 2183974163  967 LRSALKNSLLAvlpdYMVPAHMLLLENLPLTPNGKINRKAL 1007
Cdd:cd05959    471 LKEFVKDRLAP----YKYPRWIVFVDELPKTATGKIQRFKL 507

LC_FACS_like

cd05935

Putative long-chain fatty acid CoA ligase; The members of this family are putative long-chain ...

535-1007

1.42e-43

Putative long-chain fatty acid CoA ligase; The members of this family are putative long-chain fatty acyl-CoA synthetases, which catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. Fatty acyl-CoA synthetases are responsible for fatty acid degradation as well as physiological regulation of cellular functions via the production of fatty acyl-CoA esters.

Pssm-ID: 341258 [Multi-domain] Cd Length: 430 Bit Score: 166.12 E-value: 1.42e-43

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  535 RLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQYMIDDSGLRLL--L 612
Cdd:cd05935      1 SLTYLELLEVVKKLASFLSNKGVRKGDRVGICLQNSPQYVIAYFAIWRANAVVVPINPMLKERELEYILNDSGAKVAvvG 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  613 SQQSVLARLPqsdglqslllddlerlvhgypaenpdlpeapdslcyaiYTSGSTGQPKGVMVRHRALTNFVCSIARQPGM 692
Cdd:cd05935     81 SELDDLALIP--------------------------------------YTSGTTGLPKGCMHTHFSAAANALQSAVWTGL 122

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  693 LARDRLLSVTTFsFDIFGLE--LYVPLARGASMLLASReqaQDPEALLDLVERQGVTVLQATPATWRMLCDSERV---DL 767
Cdd:cd05935    123 TPSDVILACLPL-FHVTGFVgsLNTAVYVGGTYVLMAR---WDRETALELIEKYKVTFWTNIPTMLVDLLATPEFktrDL 198

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  768 LRGCTLLCGGEALAEDLAARMRGLSASTWN-LYGPTETTIWSARFRLGEEARPFLGGPLENTALYILDSE-MNPCPPGVA 845
Cdd:cd05935    199 SSLKVLTGGGAPMPPAVAEKLLKLTGLRFVeGYGLTETMSQTHTNPPLRPKLQCLGIP*FGVDARVIDIEtGRELPPNEV 278

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  846 GELLIGGDGLARGYHRRPGLTAERFLPDpfaaDGSRLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLE 925
Cdd:cd05935    279 GEIVVRGPQIFKGYWNRPEETEESFIEI----KGRRFFRTGDLGYMDEEGYFFFVDRVKRMINVSGFKVWPAEVEAKLYK 354

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  926 QDSVREAVVVAQPG-VAGPTLVAYLV--PTEAALVDAES----ARQQelrsalknsllavLPDYMVPAHMLLLENLPLTP 998
Cdd:cd05935    355 HPAI*EVCVISVPDeRVGEEVKAFIVlrPEYRGKVTEEDiiewAREQ-------------MAAYKYPREVEFVDELPRSA 421


                   ....*....
gi 2183974163  999 NGKINRKAL 1007
Cdd:cd05935    422 SGKILWRLL 430

MACS_like_3

cd05971

Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the ...

534-1007

8.14e-43

Pssm-ID: 341275 [Multi-domain] Cd Length: 439 Bit Score: 164.14 E-value: 8.14e-43

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  534 ERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQYMIDDSGLRLLLS 613
Cdd:cd05971      5 EKVTFKELKTASNRFANVLKEIGLEKGDRVGVFLSQGPECAIAHIAILRSGAIAVPLFALFGPEALEYRLSNSGASALVT 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  614 qqsvlarlpqsdglqslllddlerlvhgypaenpdlpEAPDSLCYAIYTSGSTGQPKGVMVRHRALTNFVCSIARQPGML 693
Cdd:cd05971     85 -------------------------------------DGSDDPALIIYTSGTTGPPKGALHAHRVLLGHLPGVQFPFNLF 127

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  694 ARDRLLSVTTFSFDIFG--LELYVPLARGASMLLASREQAQDPEALLDLVERQGVTVLQATPATWRML------CDSERV 765
Cdd:cd05971    128 PRDGDLYWTPADWAWIGglLDVLLPSLYFGVPVLAHRMTKFDPKAALDLMSRYGVTTAFLPPTALKMMrqqgeqLKHAQV 207

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  766 DLLrgcTLLCGGEALAEDLAARMR-GLSASTWNLYGPTEttiwsARFRLGEEARPF------LGGPLENTALYILDSEMN 838
Cdd:cd05971    208 KLR---AIATGGESLGEELLGWAReQFGVEVNEFYGQTE-----CNLVIGNCSALFpikpgsMGKPIPGHRVAIVDDNGT 279

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  839 PCPPGVAGELLIG-GDGLAR-GYHRRPGLTAERFLPDPFaadgsrlyRTGDLARYRADGVIEYLGRIDHQVKIRGFRIEL 916
Cdd:cd05971    280 PLPPGEVGEIAVElPDPVAFlGYWNNPSATEKKMAGDWL--------LTGDLGRKDSDGYFWYVGRDDDVITSSGYRIGP 351

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  917 GEIETRLLEQDSVREAVVVAQPG-VAGPTLVAYLVPTEAALVDaesarqQELRSALKNSLLAVLPDYMVPAHMLLLENLP 995
Cdd:cd05971    352 AEIEECLLKHPAVLMAAVVGIPDpIRGEIVKAFVVLNPGETPS------DALAREIQELVKTRLAAHEYPREIEFVNELP 425

                          490
                   ....*....|..
gi 2183974163  996 LTPNGKINRKAL 1007
Cdd:cd05971    426 RTATGKIRRREL 437

A_NRPS_Bac

cd17655

bacitracin synthetase and related proteins; This family of the adenylation (A) domain of ...

3089-3183

8.69e-43

Pssm-ID: 341310 [Multi-domain] Cd Length: 490 Bit Score: 165.58 E-value: 8.69e-43

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3089 RLFEEQVERTPTAPALAFGEERLDYAELNRRANRLAHALIERGIGADRLVGVAMERSIEMVVALMAILKAGGAYVPVDPE 3168
Cdd:cd17655      1 ELFEEQAEKTPDHTAVVFEDQTLTYRELNERANQLARTLREKGVGPDTIVGIMAERSLEMIVGILGILKAGGAYLPIDPD 80

                           90
                   ....*....|....*
gi 2183974163 3169 YPEERQAYMLEDSGV 3183
Cdd:cd17655     81 YPEERIQYILEDSGA 95

FAAL

cd05931

Fatty acyl-AMP ligase (FAAL); FAAL belongs to the class I adenylate forming enzyme family and ...

1576-2070

1.42e-42

Fatty acyl-AMP ligase (FAAL); FAAL belongs to the class I adenylate forming enzyme family and is homologous to fatty acyl-coenzyme A (CoA) ligases (FACLs). However, FAALs produce only the acyl adenylate and are unable to perform the thioester-forming reaction, while FACLs perform a two-step catalytic reaction; AMP ligation followed by CoA ligation using ATP and CoA as cofactors. FAALs have insertion motifs between the N-terminal and C-terminal subdomains that distinguish them from the FACLs. This insertion motif precludes the binding of CoA, thus preventing CoA ligation. It has been suggested that the acyl adenylates serve as substrates for multifunctional polyketide synthases to permit synthesis of complex lipids such as phthiocerol dimycocerosate, sulfolipids, mycolic acids, and mycobactin.

Pssm-ID: 341254 [Multi-domain] Cd Length: 547 Bit Score: 166.26 E-value: 1.42e-42

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1576 RQAAERPRATAVVY------GERALDYGELNLRANRLAHRLIELGVGPDVlVGLAAERSLEMIVGLLAILKAGGAYVPLD 1649
Cdd:cd05931      1 RRAAARPDRPAYTFlddeggREETLTYAELDRRARAIAARLQAVGKPGDR-VLLLAPPGLDFVAAFLGCLYAGAIAVPLP 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1650 PRYPS---DRLGYMIEDSGIRLLLTQRAARERL-------PLGEGLPCLLLDAEHewAGYPESDPQSAVGVDNLAYVIYT 1719
Cdd:cd05931     80 PPTPGrhaERLAAILADAGPRVVLTTAAALAAVrafaasrPAAGTPRLLVVDLLP--DTSAADWPPPSPDPDDIAYLQYT 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1720 SGSTGKPKGTLLPHGNVLRLFDATRHWFGFSADDA---W-SLFHSYAFDFSvweIFGALLHGGRLVIV-PYETSRSPEDF 1794
Cdd:cd05931    158 SGSTGTPKGVVVTHRNLLANVRQIRRAYGLDPGDVvvsWlPLYHDMGLIGG---LLTPLYSGGPSVLMsPAAFLRRPLRW 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1795 LRLLCRERVTVlnqTPS---AFkQLMQVACAGQEVPPLAL---RHVVFGGEALEVQALRPWFERFGD---RAPRLVNMYG 1865
Cdd:cd05931    235 LRLISRYRATI---SAApnfAY-DLCVRRVRDEDLEGLDLsswRVALNGAEPVRPATLRRFAEAFAPfgfRPEAFRPSYG 310

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1866 ITETTVHVT------------YRPLSLADLDGGAASPI---------GEPIPDLSWYLLDA-GLNPVPRGCIGELYVGGA 1923
Cdd:cd05931    311 LAEATLFVSggppgtgpvvlrVDRDALAGRAVAVAADDpaarelvscGRPLPDQEVRIVDPeTGRELPDGEVGEIWVRGP 390

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1924 GLARGYLNRPELSCTRFVADPfSTTGGRLYRTGDLARYRcDGVVEYVGRIDHQVKIRGFRIELGEIEARLLA-----QPG 1998
Cdd:cd05931    391 SVASGYWGRPEATAETFGALA-ATDEGGWLRTGDLGFLH-DGELYITGRLKDLIIVRGRNHYPQDIEATAEEahpalRPG 468

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2183974163 1999 VAEAVVLPHEGPGATQLVGYVVTQAAPSDPAALRDTLRQALKAslpEHMVPAH-LLFLER--LPLTANGKLDRRA 2070
Cdd:cd05931    469 CVAAFSVPDDGEERLVVVAEVERGADPADLAAIAAAIRAAVAR---EHGVAPAdVVLVRPgsIPRTSSGKIQRRA 540

ABCL

cd05958

2-aminobenzoate-CoA ligase (ABCL); ABCL catalyzes the initial step in the 2-aminobenzoate ...

1584-2071

8.07e-42

2-aminobenzoate-CoA ligase (ABCL); ABCL catalyzes the initial step in the 2-aminobenzoate aerobic degradation pathway by activating 2-aminobenzoate to 2-aminobenzoyl-CoA. The reaction is carried out via a two-step process; the first step is ATP-dependent and forms a 2-aminobenzoyl-AMP intermediate, and the second step forms the 2-aminobenzoyl-CoA ester and releases the AMP. 2-Aminobenzoyl-CoA is further converted to 2-amino-5-oxo-cyclohex-1-ene-1-carbonyl-CoA catalyzed by 2-aminobenzoyl-CoA monooxygenase/reductase. ABCL has been purified from cells aerobically grown with 2-aminobenzoate as sole carbon, energy, and nitrogen source, and has been characterized as a monomer.

Pssm-ID: 341268 [Multi-domain] Cd Length: 439 Bit Score: 161.49 E-value: 8.07e-42

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1584 ATAVVYGERALDYGELNLRANRLAHRLI-ELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGYmie 1662
Cdd:cd05958      1 RTCLRSPEREWTYRDLLALANRIANVLVgELGIVPGNRVLLRGSNSPELVACWFGIQKAGAIAVATMPLLRPKELAY--- 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1663 dsgirllltqraarerlPLGEGLPCLLLDAEHEWAgypesdpqsavgVDNLAYVIYTSGSTGKPKGTLLPHGNVLRLFDA 1742
Cdd:cd05958     78 -----------------ILDKARITVALCAHALTA------------SDDICILAFTSGTTGAPKATMHFHRDPLASADR 128

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1743 -TRHWFGFSADDAW----SLFHSYAFDFSVWEIFGAllhGGRLVIVPyetSRSPEDFLRLLCRERVTVLNQTPSAFKQLM 1817
Cdd:cd05958    129 yAVNVLRLREDDRFvgspPLAFTFGLGGVLLFPFGV---GASGVLLE---EATPDLLLSAIARYKPTVLFTAPTAYRAML 202

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1818 QVACAGQevPPLA-LRHVVFGGEALEVQALRPWFERFGdraPRLVNMYGITETtVHVtyrplsLADLDGGAASP--IGEP 1894
Cdd:cd05958    203 AHPDAAG--PDLSsLRKCVSAGEALPAALHRAWKEATG---IPIIDGIGSTEM-FHI------FISARPGDARPgaTGKP 270

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1895 IPDLSWYLLDAGLNPVPRGCIGELYVGGaglargylnrpELSCtRFVADPFSTT---GGRLYrTGDLARYRCDGVVEYVG 1971
Cdd:cd05958    271 VPGYEAKVVDDEGNPVPDGTIGRLAVRG-----------PTGC-RYLADKRQRTyvqGGWNI-TGDTYSRDPDGYFRHQG 337

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1972 RIDHQVKIRGFRIELGEIEARLLAQPGVAEAVVLPHEGPGATQLV-GYVVTQAAPSDPAALRDTLRQALKASLPEHMVPA 2050
Cdd:cd05958    338 RSDDMIVSGGYNIAPPEVEDVLLQHPAVAECAVVGHPDESRGVVVkAFVVLRPGVIPGPVLARELQDHAKAHIAPYKYPR 417

                          490       500
                   ....*....|....*....|.
gi 2183974163 2051 HLLFLERLPLTANGKLDRRAL 2071
Cdd:cd05958    418 AIEFVTELPRTATGKLQRFAL 438

COG4908

Uncharacterized conserved protein, contains a NRPS condensation (elongation) domain [General ...

2640-2874

8.18e-42

Uncharacterized conserved protein, contains a NRPS condensation (elongation) domain [General function prediction only];

Pssm-ID: 443936 [Multi-domain] Cd Length: 243 Bit Score: 155.20 E-value: 8.18e-42

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2640 LSPMQQGMLFHslyQQNSGDYINQMRLDVEG-LDPQRFREAWQAALDAHEVLRSGFLWQGalEKPLQLVRKRVEVPFSVH 2718
Cdd:COG4908      1 LSPAQKRFLFL---EPGSNAYNIPAVLRLEGpLDVEALERALRELVRRHPALRTRFVEED--GEPVQRIDPDADLPLEVV 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2719 DWRD--RADLAEALDALAAGEAGLGFELAEAPLLRLVLVRTGERRHHLIYTNHHILMDGWSNSQLLGEVLQRYRGETPSR 2796
Cdd:COG4908     76 DLSAlpEPEREAELEELVAEEASRPFDLARGPLLRAALIRLGEDEHVLLLTIHHIISDGWSLGILLRELAALYAALLEGE 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2797 S------DGRYRDYIAWLQRQ----DAGRTEAFWKQRLQRLGEPTLLVPAFAHGVRGAEGHADRYRQLDVTTSQRLAEFA 2866
Cdd:COG4908    156 PpplpelPIQYADYAAWQRAWlqseALEKQLEYWRQQLAGAPPVLELPTDRPRPAVQTFRGATLSFTLPAELTEALKALA 235


                   ....*...
gi 2183974163 2867 REQKVTLN 2874
Cdd:COG4908    236 KAHGATVN 243

PRK06178

acyl-CoA synthetase; Validated

496-1007

1.35e-41

acyl-CoA synthetase; Validated

Pssm-ID: 235724 [Multi-domain] Cd Length: 567 Bit Score: 163.67 E-value: 1.35e-41

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  496 LQRSRLPAS-----EYPAGQ-GVHRLFEAQAGLTPDAPALLFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALER 569
Cdd:PRK06178    13 LQQAAWPAGiprepEYPHGErPLTEYLRAWARERPQRPAIIFYGHVITYAELDELSDRFAALLRQRGVGAGDRVAVFLPN 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  570 GVPMVVALLAVLKAGGAYVPLDPQYPADRLQYMIDDSGLRLLLSQ-------QSVLARLPQSDGLQSLLLD--------- 633
Cdd:PRK06178    93 CPQFHIVFFGILKLGAVHVPVSPLFREHELSYELNDAGAEVLLALdqlapvvEQVRAETSLRHVIVTSLADvlpaeptlp 172

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  634 ----------------DLERLVHGYPAENPDLPEAPDSLCYAIYTSGSTGQPKGVMVRHR-----ALTNFVCSIARQPGm 692
Cdd:PRK06178   173 lpdslraprlaaagaiDLLPALRACTAPVPLPPPALDALAALNYTGGTTGMPKGCEHTQRdmvytAAAAYAVAVVGGED- 251

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  693 lardrllSVTTFSFDIF-----GLELYVPLARGASMLLASReqaQDPEALLDLVERQGVTVLQATPATWRMLCDSERV-- 765
Cdd:PRK06178   252 -------SVFLSFLPEFwiageNFGLLFPLFSGATLVLLAR---WDAVAFMAAVERYRVTRTVMLVDNAVELMDHPRFae 321

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  766 -DL--LRGCTLLCGGEALAEDLAARMRGLSASTW--NLYGPTET----TIwSARFRLGEE---ARP-FLGGPLENTALYI 832
Cdd:PRK06178   322 yDLssLRQVRVVSFVKKLNPDYRQRWRALTGSVLaeAAWGMTEThtcdTF-TAGFQDDDFdllSQPvFVGLPVPGTEFKI 400

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  833 LDSEMN-PCPPGVAGELLIGGDGLARGYHRRPGLTAERFlpdpfaADGsrLYRTGDLARYRADGVIEYLGRIDHQVKIRG 911
Cdd:PRK06178   401 CDFETGeLLPLGAEGEIVVRTPSLLKGYWNKPEATAEAL------RDG--WLHTGDIGKIDEQGFLHYLGRRKEMLKVNG 472

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  912 FRIELGEIETRLLEQDSVREAVVVAQPGV-AGPTLVAYLVPTEAALVDAEsarqqELRSALKNSLLAvlpdYMVPaHMLL 990
Cdd:PRK06178   473 MSVFPSEVEALLGQHPAVLGSAVVGRPDPdKGQVPVAFVQLKPGADLTAA-----ALQAWCRENMAV----YKVP-EIRI 542

                          570
                   ....*....|....*..
gi 2183974163  991 LENLPLTPNGKINRKAL 1007
Cdd:PRK06178   543 VDALPMTATGKVRKQDL 559

CT_NRPS-like

Terminal Condensation (CT)-like domains of nonribosomal peptide synthetases (NRPSs); Unlike ...

70-477

1.73e-41

Pssm-ID: 380464 [Multi-domain] Cd Length: 401 Bit Score: 159.39 E-value: 1.73e-41

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163   70 YNIPSALRLRGELDVEALSASLGAIVERHQSLRTVFVEDEQLDGFRQQVLASVDVPVPVTlagdDDAQAQIRAFVESETQ 149
Cdd:cd19542     22 YFNHFVFDLDSSVDVERLRNAWRQLVQRHDILRTVFVESSAEGTFLQVVLKSLDPPIEEV----ETDEDSLDALTRDLLD 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  150 QPFdLRNGPLLRARLLRLAADDHVLTLTIHHVAADGWSMRVLVEELIALYgarrqgiEATLPDLPIQYADYAiwqRHwLE 229
Cdd:cd19542     98 DPT-LFGQPPHRLTLLETSSGEVYLVLRISHALYDGVSLPIILRDLAAAY-------NGQLLPPAPPFSDYI---SY-LQ 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  230 AGERERQLEYWMARLGGGQSVLElptdrqrPALPSYRGARHELQLPQALGRQLQALAQREGTTLFMLLLASFQALLHRYS 309
Cdd:cd19542    166 SQSQEESLQYWRKYLQGASPCAF-------PSLSPKRPAERSLSSTRRSLAKLEAFCASLGVTLASLFQAAWALVLARYT 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  310 GQDEIRVGVPVANRN--RVETERLIGFFVNTQVLRADLDAQMPFLDLLQQTRVAALGAQSHQDLPFEQLVEALqpeRSLS 387
Cdd:cd19542    239 GSRDVVFGYVVSGRDlpVPGIDDIVGPCINTLPVRVKLDPDWTVLDLLRQLQQQYLRSLPHQHLSLREIQRAL---GLWP 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  388 HSPLFQAMYNHQNLGSAGrqslAAQLPGLSVEDLSWGAHSAQFDLTLDTYESEQGVHAEFTYATDLFEAATVERLARHWR 467
Cdd:cd19542    316 SGTLFNTLVSYQNFEASP----ESELSGSSVFELSAAEDPTEYPVAVEVEPSGDSLKVSLAYSTSVLSEEQAEELLEQFD 391

                          410
                   ....*....|
gi 2183974163  468 NLLEAVVAEP 477
Cdd:cd19542    392 DILEALLANP 401

PRK04319

acetyl-CoA synthetase; Provisional

1531-2073

2.01e-41

acetyl-CoA synthetase; Provisional

Pssm-ID: 235279 [Multi-domain] Cd Length: 570 Bit Score: 163.14 E-value: 2.01e-41

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1531 IVARPEARIAELKLLDEAEARADLlQWNPGPQDFT--PASCL---HRLIERQAA-ERPRATAVVY----GERALDYGELN 1600
Cdd:PRK04319     2 KVETLPVIKGEPNLKDYEETYATF-SWEEVEKEFSwlETGKVniaYEAIDRHADgGRKDKVALRYldasRKEKYTYKELK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1601 LRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPL----DPRYPSDRLgymiEDSGIRLLLTQRAAR 1676
Cdd:PRK04319    81 ELSNKFANVLKELGVEKGDRVFIFMPRIPELYFALLGALKNGAIVGPLfeafMEEAVRDRL----EDSEAKVLITTPALL 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1677 ERLPLGEgLPCL---------------LLDAEHEWAGYPESDPQSAVGVDNLAYVIYTSGSTGKPKGTLLPHGN------ 1735
Cdd:PRK04319   157 ERKPADD-LPSLkhvllvgedveegpgTLDFNALMEQASDEFDIEWTDREDGAILHYTSGSTGKPKGVLHVHNAmlqhyq 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1736 ----VLRLFDATRHWfgFSADDAWSLFHSYAfdfsvweIFGALLHGGRLVIvpYETSRSPEDFLRLLCRERVTVLNQTPS 1811
Cdd:PRK04319   236 tgkyVLDLHEDDVYW--CTADPGWVTGTSYG-------IFAPWLNGATNVI--DGGRFSPERWYRILEDYKVTVWYTAPT 304

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1812 AFKQLMQvacAGQEVPP----LALRHVVFGGEALEVQALRpWFER-FGDrapRLVNMYGITETTVH--VTY-----RPLS 1879
Cdd:PRK04319   305 AIRMLMG---AGDDLVKkydlSSLRHILSVGEPLNPEVVR-WGMKvFGL---PIHDNWWMTETGGImiANYpamdiKPGS 377

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1880 LadldggaaspiGEPIPDLSWYLLDAGLNPVPRGCIGELYV--GGAGLARGYLNRPE--LSCtrFVADpfsttggrLYRT 1955
Cdd:PRK04319   378 M-----------GKPLPGIEAAIVDDQGNELPPNRMGNLAIkkGWPSMMRGIWNNPEkyESY--FAGD--------WYVS 436

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1956 GDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVVLPHEGPGATQLV--------GYvvtqaAPSD 2027
Cdd:PRK04319   437 GDSAYMDEDGYFWFQGRVDDVIKTSGERVGPFEVESKLMEHPAVAEAGVIGKPDPVRGEIIkafvalrpGY-----EPSE 511

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....*.
gi 2183974163 2028 paALRDTLRQALKASLPEHMVPAHLLFLERLPLTANGKLDRRALPA 2073
Cdd:PRK04319   512 --ELKEEIRGFVKKGLGAHAAPREIEFKDKLPKTRSGKIMRRVLKA 555

PRK06839

o-succinylbenzoate--CoA ligase;

1574-2071

3.42e-41

o-succinylbenzoate--CoA ligase;

Pssm-ID: 168698 [Multi-domain] Cd Length: 496 Bit Score: 160.80 E-value: 3.42e-41

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1574 IERQAAERPRATAVVYGERALDYGELNLRANRLAHRLI-ELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRY 1652
Cdd:PRK06839     8 IEKRAYLHPDRIAIITEEEEMTYKQLHEYVSKVAAYLIyELNVKKGERIAILSQNSLEYIVLLFAIAKVECIAVPLNIRL 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1653 PSDRLGYMIEDSGIRLLLTQR---AARERLPLGEGL--------PCLLLDAEHEWAGYP-ESDPqsavgvdnlaYVI-YT 1719
Cdd:PRK06839    88 TENELIFQLKDSGTTVLFVEKtfqNMALSMQKVSYVqrvisitsLKEIEDRKIDNFVEKnESAS----------FIIcYT 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1720 SGSTGKPKGTLLPHGNVlrLFDATRHWFG--FSADDA----WSLFHSYAFDFSVweiFGALLHGGRlVIVPYETsrSPED 1793
Cdd:PRK06839   158 SGTTGKPKGAVLTQENM--FWNALNNTFAidLTMHDRsivlLPLFHIGGIGLFA---FPTLFAGGV-IIVPRKF--EPTK 229

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1794 FLRLLCRERVTVLNQTPSAFKQLMQvaCAGQEVPPL-ALRHVVFGGEALEVQALRpwfeRFGDRAPRLVNMYGITETTVH 1872
Cdd:PRK06839   230 ALSMIEKHKVTVVMGVPTIHQALIN--CSKFETTNLqSVRWFYNGGAPCPEELMR----EFIDRGFLFGQGFGMTETSPT 303

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1873 VTYrpLSLADLDGGAASpIGEPIPDLSWYLLDAGLNPVPRGCIGELYVGGAGLARGYLNRPElsctrfvADPFSTTGGRL 1952
Cdd:PRK06839   304 VFM--LSEEDARRKVGS-IGKPVLFCDYELIDENKNKVEVGEVGELLIRGPNVMKEYWNRPD-------ATEETIQDGWL 373

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1953 YrTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVVL--PHEGPGATQLVGYVVTQAAPSDPAA 2030
Cdd:PRK06839   374 C-TGDLARVDEDGFVYIVGRKKEMIISGGENIYPLEVEQVINKLSDVYEVAVVgrQHVKWGEIPIAFIVKKSSSVLIEKD 452

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|.
gi 2183974163 2031 LRDTLRQalkaSLPEHMVPAHLLFLERLPLTANGKLDRRAL 2071
Cdd:PRK06839   453 VIEHCRL----FLAKYKIPKEIVFLKELPKNATGKIQKAQL 489

PRK08316

acyl-CoA synthetase; Validated

520-1002

5.74e-41

acyl-CoA synthetase; Validated

Pssm-ID: 181381 [Multi-domain] Cd Length: 523 Bit Score: 160.87 E-value: 5.74e-41

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  520 AGLTPDAPALLFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRL 599
Cdd:PRK08316    21 ARRYPDKTALVFGDRSWTYAELDAAVNRVAAALLDLGLKKGDRVAALGHNSDAYALLWLACARAGAVHVPVNFMLTGEEL 100

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  600 QYMIDDSGLRLLLSQ-------QSVLARLPQSDGLQSLLLD---------DLERLVHGYPAENPDLPEAPDSLCYAIYTS 663
Cdd:PRK08316   101 AYILDHSGARAFLVDpalaptaEAALALLPVDTLILSLVLGgreapggwlDFADWAEAGSVAEPDVELADDDLAQILYTS 180

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  664 GSTGQPKGVMVRHRALT-NFVCSIArQPGMLARDRLLSVT----TFSFDIF-GLELYVplarGASMLLAsreQAQDPEAL 737
Cdd:PRK08316   181 GTESLPKGAMLTHRALIaEYVSCIV-AGDMSADDIPLHALplyhCAQLDVFlGPYLYV----GATNVIL---DAPDPELI 252

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  738 LDLVERQGVTVLQATPATWRMLC---DSERVDL--LRGCtllCGG------EALAEdLAARMRGLsaSTWNLYGPTE--- 803
Cdd:PRK08316   253 LRTIEAERITSFFAPPTVWISLLrhpDFDTRDLssLRKG---YYGasimpvEVLKE-LRERLPGL--RFYNCYGQTEiap 326

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  804 -TTIWSAR---FRLGEEARPFLggpleNTALYILDSEMNPCPPGVAGELLIGGDGLARGYHRRPGLTAERFlpdpfaADG 879
Cdd:PRK08316   327 lATVLGPEehlRRPGSAGRPVL-----NVETRVVDDDGNDVAPGEVGEIVHRSPQLMLGYWDDPEKTAEAF------RGG 395

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  880 srLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQPG-VAGPTLVAYLVPTEAALVD 958
Cdd:PRK08316   396 --WFHSGDLGVMDEEGYITVVDRKKDMIKTGGENVASREVEEALYTHPAVAEVAVIGLPDpKWIEAVTAVVVPKAGATVT 473

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*...
gi 2183974163  959 AES----ARQQelrsalknsllavLPDYMVPAHMLLLENLPLTPNGKI 1002
Cdd:PRK08316   474 EDEliahCRAR-------------LAGFKVPKRVIFVDELPRNPSGKI 508

PRK07798

acyl-CoA synthetase; Validated

1573-2069

7.78e-41

acyl-CoA synthetase; Validated

Pssm-ID: 236100 [Multi-domain] Cd Length: 533 Bit Score: 160.82 E-value: 7.78e-41

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1573 LIERQAAERPRATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRY 1652
Cdd:PRK07798     8 LFEAVADAVPDRVALVCGDRRLTYAELEERANRLAHYLIAQGLGPGDHVGIYARNRIEYVEAMLGAFKARAVPVNVNYRY 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1653 PSDRLGYMIEDSGIRLLLTQR-------AARERLP-------LGEGLPCLLLDAEHEW-----AGYPESD--PQSAvgvD 1711
Cdd:PRK07798    88 VEDELRYLLDDSDAVALVYERefaprvaEVLPRLPklrtlvvVEDGSGNDLLPGAVDYedalaAGSPERDfgERSP---D 164

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1712 NLaYVIYTSGSTGKPKGTLLPHGNVLR-LFDATRHWFGFSADDAWSLFHSYAFDF--------------SVWEIFGALLH 1776
Cdd:PRK07798   165 DL-YLLYTGGTTGMPKGVMWRQEDIFRvLLGGRDFATGEPIEDEEELAKRAAAGPgmrrfpapplmhgaGQWAAFAALFS 243

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1777 GGRLVIVPyETSRSPEDFLRLLCRERVTVLNQTPSAFKQLMQVACAGQEVPPL-ALRHVVFGGEALEVQALRPWFERFGD 1855
Cdd:PRK07798   244 GQTVVLLP-DVRFDADEVWRTIEREKVNVITIVGDAMARPLLDALEARGPYDLsSLFAIASGGALFSPSVKEALLELLPN 322

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1856 RAprLVNMYGITETTVHVTYRPLSLADLDGGAASPIGEpipdlSWYLLDAGLNPVPRGcigelyVGGAG-LAR------G 1928
Cdd:PRK07798   323 VV--LTDSIGSSETGFGGSGTVAKGAVHTGGPRFTIGP-----RTVVLDEDGNPVEPG------SGEIGwIARrghiplG 389

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1929 YLNRPELSctrfvADPFSTTGGRLYR-TGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVV--L 2005
Cdd:PRK07798   390 YYKDPEKT-----AETFPTIDGVRYAiPGDRARVEADGTITLLGRGSVCINTGGEKVFPEEVEEALKAHPDVADALVvgV 464

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2183974163 2006 PHEGPGatQLVGYVVTQAAPSDPAAlrDTLRQALKASLPEHMVPAHLLFLERLPLTANGKLDRR 2069
Cdd:PRK07798   465 PDERWG--QEVVAVVQLREGARPDL--AELRAHCRSSLAGYKVPRAIWFVDEVQRSPAGKADYR 524

23DHB-AMP_lg

cd05920

2,3-dihydroxybenzoate-AMP ligase; 2,3-dihydroxybenzoate-AMP ligase activates 2, ...

506-1007

2.31e-40

Pssm-ID: 341244 [Multi-domain] Cd Length: 482 Bit Score: 158.26 E-value: 2.31e-40

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  506 YPAGQGVHRLFEAQAGLTPDAPALLFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGG 585
Cdd:cd05920     11 YWQDEPLGDLLARSAARHPDRIAVVDGDRRLTYRELDRRADRLAAGLRGLGIRPGDRVVVQLPNVAEFVVLFFALLRLGA 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  586 AYVPLDPQYPADRLQYMIDDSGLRLLlsqqsVLARLPQSDGLQSLLLDDLErlvhgypaenpdlpEAPDSLCYAIyTSGS 665
Cdd:cd05920     91 VPVLALPSHRRSELSAFCAHAEAVAY-----IVPDRHAGFDHRALARELAE--------------SIPEVALFLL-SGGT 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  666 TGQPKGVMVRHRALTNFVCSIARQPGMLARDRLLSVTTFSFD-------IFGLelyvpLARGASMLLASREqaqDPEALL 738
Cdd:cd05920    151 TGTPKLIPRTHNDYAYNVRASAEVCGLDQDTVYLAVLPAAHNfplacpgVLGT-----LLAGGRVVLAPDP---SPDAAF 222

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  739 DLVERQGVTVLQATPAT---WRMLCDSERVDLLRGCTLLCGGEALAEDLAARMRG-LSASTWNLYGPTETTIWSARFR-- 812
Cdd:cd05920    223 PLIEREGVTVTALVPALvslWLDAAASRRADLSSLRLLQVGGARLSPALARRVPPvLGCTLQQVFGMAEGLLNYTRLDdp 302

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  813 ----LGEEARPFlgGPLENtaLYILDSEMNPCPPGVAGELLIGGDGLARGYHRRPGLTAERFLPDPFaadgsrlYRTGDL 888
Cdd:cd05920    303 deviIHTQGRPM--SPDDE--IRVVDEEGNPVPPGEEGELLTRGPYTIRGYYRAPEHNARAFTPDGF-------YRTGDL 371

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  889 ARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQPG-VAGPTLVAYLVPTEAALvdaesaRQQEL 967
Cdd:cd05920    372 VRRTPDGYLVVEGRIKDQINRGGEKIAAEEVENLLLRHPAVHDAAVVAMPDeLLGERSCAFVVLRDPPP------SAAQL 445

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|
gi 2183974163  968 RSALKNSLLAvlpDYMVPAHMLLLENLPLTPNGKINRKAL 1007
Cdd:cd05920    446 RRFLRERGLA---AYKLPDRIEFVDSLPLTAVGKIDKKAL 482

ACS-like

cd17634

acetate-CoA ligase; This family includes acyl- and aryl-CoA ligases, as well as the ...

1550-2066

2.49e-40

acetate-CoA ligase; This family includes acyl- and aryl-CoA ligases, as well as the adenylation domain of nonribosomal peptide synthetases and firefly luciferases. The adenylate-forming enzymes catalyze an ATP-dependent two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein. The active site of the domain is located at the interface of a large N-terminal subdomain and a smaller C-terminal subdomain.

Pssm-ID: 341289 [Multi-domain] Cd Length: 587 Bit Score: 160.44 E-value: 2.49e-40

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1550 ARADLLQWNPGPQDFTPASCLhrliERQAAERPRATAVVY------GERALDYGELNLRANRLAHRLIELGVGPDVLVGL 1623
Cdd:cd17634     39 PGAPSIKWFEDATLNLAANAL----DRHLRENGDRTAIIYegddtsQSRTISYRELHREVCRFAGTLLDLGVKKGDRVAI 114

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1624 AAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGYMIEDSGIRLLLT-----------------QRAA----------- 1675
Cdd:cd17634    115 YMPMIPEAAVAMLACARIGAVHSVIFGGFAPEAVAGRIIDSSSRLLITadggvragrsvplkknvDDALnpnvtsvehvi 194

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1676 ---RERLPLGeGLPCLLLDAEHEWAGYPESDPQSAVGVDNLAYVIYTSGSTGKPKGTLLPHGN-VLRLFDATRHWFGFSA 1751
Cdd:cd17634    195 vlkRTGSDID-WQEGRDLWWRDLIAKASPEHQPEAMNAEDPLFILYTSGTTGKPKGVLHTTGGyLVYAATTMKYVFDYGP 273

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1752 DD--------AWSLFHSyafdfsvWEIFGALLHGGRLVIvpYE---TSRSPEDFLRLLCRERVTVLNQTPSAFKQLMQVA 1820
Cdd:cd17634    274 GDiywctadvGWVTGHS-------YLLYGPLACGATTLL--YEgvpNWPTPARMWQVVDKHGVNILYTAPTAIRALMAAG 344

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1821 CAGQEVPPLALRHVVFG-GEALEVQALRPWFERFGDRAPRLVNMYGITETT-VHVTYRPLsLADLDGGAASpigEPIPDL 1898
Cdd:cd17634    345 DDAIEGTDRSSLRILGSvGEPINPEAYEWYWKKIGKEKCPVVDTWWQTETGgFMITPLPG-AIELKAGSAT---RPVFGV 420

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1899 SWYLLDAGLNPVPRGCIGELYVGGA--GLARGYLNRPElsctRFVADPFSTTGGrLYRTGDLARYRCDGVVEYVGRIDHQ 1976
Cdd:cd17634    421 QPAVVDNEGHPQPGGTEGNLVITDPwpGQTRTLFGDHE----RFEQTYFSTFKG-MYFSGDGARRDEDGYYWITGRSDDV 495

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1977 VKIRGFRIELGEIEARLLAQPGVAEAVV--LPHEGPGaTQLVGYVVTQAAPSDPAALRDTLRQALKASLPEHMVPAHLLF 2054
Cdd:cd17634    496 INVAGHRLGTAEIESVLVAHPKVAEAAVvgIPHAIKG-QAPYAYVVLNHGVEPSPELYAELRNWVRKEIGPLATPDVVHW 574

                          570
                   ....*....|..
gi 2183974163 2055 LERLPLTANGKL 2066
Cdd:cd17634    575 VDSLPKTRSGKI 586

DCL_NRPS-like

DCL-type Condensation domains of nonribosomal peptide synthetases (NRPSs), such as terminal ...

49-477

9.13e-40

Pssm-ID: 380459 [Multi-domain] Cd Length: 419 Bit Score: 154.91 E-value: 9.13e-40

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163   49 PLSYAQERQWFLWQMDPQSAAYNIPSALRLRGELDVEALSASLGAIVERHQSLRTVFVEDEqLDGFRQQVLASVDVPVP- 127
Cdd:cd19536      3 PLSSLQEGMLFHSLLNPGGSVYLHNYTYTVGRRLNLDLLLEALQVLIDRHDILRTSFIEDG-LGQPVQVVHRQAQVPVTe 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  128 VTLAGDDDAQAQIRAFVESETQQPFDLRNGPLLRARLLRLAADDH-VLTLTIHHVAADGWSMRVLVEELIALYGARRQGI 206
Cdd:cd19536     82 LDLTPLEEQLDPLRAYKEETKIRRFDLGRAPLVRAALVRKDERERfLLVISDHHSILDGWSLYLLVKEILAVYNQLLEYK 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  207 EATLPdlPIQ-YADYAIWQRhwlEAGERERQLEYWMARLGGgqsvLELPTdrqRPALPSYRGARHELQLPQALGRQLQA- 284
Cdd:cd19536    162 PLSLP--PAQpYRDFVAHER---ASIQQAASERYWREYLAG----ATLAT---LPALSEAVGGGPEQDSELLVSVPLPVr 229

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  285 ---LAQREGTTLFMLLLASFQALLHRYSGQDEIRVGVPVANRNRVET--ERLIGFFVNTQVLRADLdAQMPFLDLLQQTR 359
Cdd:cd19536    230 srsLAKRSGIPLSTLLLAAWALVLSRHSGSDDVVFGTVVHGRSEETTgaERLLGLFLNTLPLRVTL-SEETVEDLLKRAQ 308

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  360 VAALGAQSHQDLPfeqlVEALQpeRSLSHSPLFQAMYNHQNlgsaGRQSLAAQLPGLSVEDLSWGAHSAQ---FDLTLDT 436
Cdd:cd19536    309 EQELESLSHEQVP----LADIQ--RCSEGEPLFDSIVNFRH----FDLDFGLPEWGSDEGMRRGLLFSEFksnYDVNLSV 378

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|.
gi 2183974163  437 YESEQGVHAEFTYATDLFEAATVERLARHWRNLLEAVVAEP 477
Cdd:cd19536    379 LPKQDRLELKLAYNSQVLDEEQAQRLAAYYKSAIAELATAP 419

C_NRPS-like

Condensation family domain with an atypical active site motif; Condensation (C) domains of ...

1119-1534

9.15e-40

Condensation family domain with an atypical active site motif; Condensation (C) domains of nonribosomal peptide synthetases (NRPSs) catalyze peptide bond formation within (usually) large multi-modular enzymatic complexes. C-domains typically have a conserved HHxxxD motif at the active site; mutations in this motif can abolish or diminish condensation activity. Members of this subfamily typically have a non-canonical conserved SHXXXDX(14)Y motif. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long (with various activities such as antibiotic, antifungal, antitumor and immunosuppression). There are various subtypes of C-domains such as the LCL-type which catalyzes peptide bond formation between two L-amino acids, the DCL-type which links an L-amino acid to the D-amino acid at the end of a growing peptide, starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and heterocyclization (Cyc) domains which catalyze both peptide bond formation and cyclization of Cys, Ser, or Thr residues. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the epimerization (E) domain, the ester-bond forming C-domain, dual E/C (epimerization and condensation) domains, and the X-domain.

Pssm-ID: 380460 [Multi-domain] Cd Length: 395 Bit Score: 153.88 E-value: 9.15e-40

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1119 ERQWFIW-RLDPHSAAYNIPVALRLKGPLRRDALQGALDLLVQRHETLRTTFVEHDGAPRQVIHPTLPiaieeRRPPVAG 1197
Cdd:cd19537      8 EREWWHKyQLSTGTSSFNVSFACRLSGDVDRDRLASAWNTVLARHRILRSRYVPRDGGLRRSYSSSPP-----RVQRVDT 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1198 EDlkglVETEAHRPFDLqrgpllrvlllplATDECV--------LVLTLHHIIADGWSMQVLVDELIRVYAALRhdqppa 1269
Cdd:cd19537     83 LD----VWKEINRPFDL-------------EREDPIrvfispdtLLVVMSHIICDLTTLQLLLREVSAAYNGKL------ 139

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1270 LAELPIQYADFAAWQRQwmdggERERQLDYWVSRLGGeQPLLELPsdrPRPQQQSHRGRRIGIPLPAELAEALRRLAQAE 1349
Cdd:cd19537    140 LPPVRREYLDSTAWSRP-----ASPEDLDFWSEYLSG-LPLLNLP---RRTSSKSYRGTSRVFQLPGSLYRSLLQFSTSS 210

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1350 QGTLFMLLLASFQALLHRYSGQNDIRVGVPIANRNREETEGLIGFFvntqvlraeLDgQLPFR------------ELLRQ 1417
Cdd:cd19537    211 GITLHQLALAAVALALQDLSDRTDIVLGAPYLNRTSEEDMETVGLF---------LE-PLPIRirfpsssdasaaDFLRA 280

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1418 VRQAVVEAQGHQdLPFEQLVDALQPERSLSHAPLFQVM--YNhqrdDHRGSRfaslGELEVEDLawDVQT-----AQFDL 1490
Cdd:cd19537    281 VRRSSQAALAHA-IPWHQLLEHLGLPPDSPNHPLFDVMvtFH----DDRGVS----LALPIPGV--EPLYtwaegAKFPL 349

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*
gi 2183974163 1491 TLD-TYESSNGLLAELTYATDLFDASSAERIAGHWLNLLRSIVAR 1534
Cdd:cd19537    350 MFEfTALSDDSLLLRLEYDTDCFSEEEIDRIESLILAALELLVEG 394

CHC_CoA_lg

cd05903

Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); ...

535-1002

1.29e-39

Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Cyclohexanecarboxylate-CoA ligase activates the aliphatic ring compound, cyclohexanecarboxylate, for degradation. It catalyzes the synthesis of cyclohexanecarboxylate-CoA thioesters in a two-step reaction involving the formation of cyclohexanecarboxylate-AMP anhydride, followed by the nucleophilic substitution of AMP by CoA.

Pssm-ID: 341229 [Multi-domain] Cd Length: 437 Bit Score: 154.85 E-value: 1.29e-39

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  535 RLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQYMIDDSGLRLLLSQ 614
Cdd:cd05903      1 RLTYSELDTRADRLAAGLAALGVGPGDVVAFQLPNWWEFAVLYLACLRIGAVTNPILPFFREHELAFILRRAKAKVFVVP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  615 QSVLARLPQSDglqslllddlerlvhgypaenpdlpeaPDSLCYAIYTSGSTGQPKGVMVRHRALTNFVCSIARQPGMLA 694
Cdd:cd05903     81 ERFRQFDPAAM---------------------------PDAVALLLFTSGTTGEPKGVMHSHNTLSASIRQYAERLGLGP 133

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  695 RDRLLSVTTFSFDI-FGLELYVPLARGASMLLASReqaQDPEALLDLVERQGVTVLQATPATWRMLCDS-----ERVDLL 768
Cdd:cd05903    134 GDVFLVASPMAHQTgFVYGFTLPLLLGAPVVLQDI---WDPDKALALMREHGVTFMMGATPFLTDLLNAveeagEPLSRL 210

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  769 RgcTLLCGG----EALAEDLAARMRGLSASTWnlyGPTETTIWSARFRLGEEARPFL--GGPLENTALYILDSEMNPCPP 842
Cdd:cd05903    211 R--TFVCGGatvpRSLARRAAELLGAKVCSAY---GSTECPGAVTSITPAPEDRRLYtdGRPLPGVEIKVVDDTGATLAP 285

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  843 GVAGELLIGGDGLARGYHRRPGLTAeRFLPDPFaadgsrlYRTGDLARYRADGVIEYLGRiDHQVKIR-GFRIELGEIET 921
Cdd:cd05903    286 GVEGELLSRGPSVFLGYLDRPDLTA-DAAPEGW-------FRTGDLARLDEDGYLRITGR-SKDIIIRgGENIPVLEVED 356

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  922 RLLEQDSVREAVVVAQPGV-AGPTLVAYLVPTEAALVDAEsarqqELRSALKNSLLAvlpDYMVPAHMLLLENLPLTPNG 1000
Cdd:cd05903    357 LLLGHPGVIEAAVVALPDErLGERACAVVVTKSGALLTFD-----ELVAYLDRQGVA---KQYWPERLVHVDDLPRTPSG 428


                   ..
gi 2183974163 1001 KI 1002
Cdd:cd05903    429 KV 430

PRK07514

malonyl-CoA synthase; Validated

1576-2065

2.42e-39

malonyl-CoA synthase; Validated

Pssm-ID: 181011 [Multi-domain] Cd Length: 504 Bit Score: 155.42 E-value: 2.42e-39

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1576 RQAAERPRATAV-VYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPS 1654
Cdd:PRK07514    10 RAAFADRDAPFIeTPDGLRYTYGDLDAASARLANLLVALGVKPGDRVAVQVEKSPEALALYLATLRAGAVFLPLNTAYTL 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1655 DRLGYMIEDSGIRLLLTQRAARERL-PLGE--GLPCLL-LDAEHEW------AGYPESDPQSAVGVDNLAYVIYTSGSTG 1724
Cdd:PRK07514    90 AELDYFIGDAEPALVVCDPANFAWLsKIAAaaGAPHVEtLDADGTGslleaaAAAPDDFETVPRGADDLAAILYTSGTTG 169

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1725 KPKGTLLPHGNVLRLFDATRHWFGFSADD----AWSLFHSYAfdfsvweIF----GALLHGGRLVIVPyetSRSPEDFLR 1796
Cdd:PRK07514   170 RSKGAMLSHGNLLSNALTLVDYWRFTPDDvlihALPIFHTHG-------LFvatnVALLAGASMIFLP---KFDPDAVLA 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1797 LLcrERVTVLNQTPSAFKQLMQVACAGQEvpplALRHV---VFGGEALEVQALRPWFERFGDrapRLVNMYGITETTVhV 1873
Cdd:PRK07514   240 LM--PRATVMMGVPTFYTRLLQEPRLTRE----AAAHMrlfISGSAPLLAETHREFQERTGH---AILERYGMTETNM-N 309

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1874 TYRPLSlADLDGGAaspIGEPIPDLSWYLLDAGLN-PVPRGCIGELYVGGAGLARGYLNRPELSCTRFVADPFsttggrl 1952
Cdd:PRK07514   310 TSNPYD-GERRAGT---VGFPLPGVSLRVTDPETGaELPPGEIGMIEVKGPNVFKGYWRMPEKTAEEFRADGF------- 378

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1953 YRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAE-AVV-LPHE--GPGATQLVgyVVTQAAPSDP 2028
Cdd:PRK07514   379 FITGDLGKIDERGYVHIVGRGKDLIISGGYNVYPKEVEGEIDELPGVVEsAVIgVPHPdfGEGVTAVV--VPKPGAALDE 456

                          490       500       510
                   ....*....|....*....|....*....|....*..
gi 2183974163 2029 AAlrdtLRQALKASLPEHMVPAHLLFLERLPLTANGK 2065
Cdd:PRK07514   457 AA----ILAALKGRLARFKQPKRVFFVDELPRNTMGK 489

PRK13295

cyclohexanecarboxylate-CoA ligase; Reviewed

485-1007

4.04e-39

cyclohexanecarboxylate-CoA ligase; Reviewed

Pssm-ID: 171961 [Multi-domain] Cd Length: 547 Bit Score: 155.98 E-value: 4.04e-39

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  485 PLLDAEERAtllqRSRlpaseyPAGQGVHRL----FEAQAGLTPDAPALL------FGEERLSYAELNALANRLAWRLRE 554
Cdd:PRK13295     5 AVLLPPRRA----ASI------AAGHWHDRTinddLDACVASCPDKTAVTavrlgtGAPRRFTYRELAALVDRVAVGLAR 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  555 EGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQYMIDDSGLRLLLSQQ--------SVLARL-PQSD 625
Cdd:PRK13295    75 LGVGRGDVVSCQLPNWWEFTVLYLACSRIGAVLNPLMPIFRERELSFMLKHAESKVLVVPKtfrgfdhaAMARRLrPELP 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  626 GLQSLLL------DDLERLVHGYPAEN-PDLPE-------APDSLCYAIYTSGSTGQPKGVMVRHRALTNFVCSIARQPG 691
Cdd:PRK13295   155 ALRHVVVvggdgaDSFEALLITPAWEQePDAPAilarlrpGPDDVTQLIYTSGTTGEPKGVMHTANTLMANIVPYAERLG 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  692 MLARDRLLSVTTFSFDI-FGLELYVPLARGASMLLasrEQAQDPEALLDLVERQGVT-VLQATPatwrMLCDSERVDLLR 769
Cdd:PRK13295   235 LGADDVILMASPMAHQTgFMYGLMMPVMLGATAVL---QDIWDPARAAELIRTEGVTfTMASTP----FLTDLTRAVKES 307

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  770 GC------TLLCGGEALAEDLAARMR-GLSASTWNLYGPTETTIWSArFRLG---EEARPFLGGPLENTALYILDSEMNP 839
Cdd:PRK13295   308 GRpvsslrTFLCAGAPIPGALVERARaALGAKIVSAWGMTENGAVTL-TKLDdpdERASTTDGCPLPGVEVRVVDADGAP 386

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  840 CPPGVAGELLIGGDGLARGYHRRPGLTAErflpdpfAADGsrLYRTGDLARYRADGVIEYLGRiDHQVKIRGFR-IELGE 918
Cdd:PRK13295   387 LPAGQIGRLQVRGCSNFGGYLKRPQLNGT-------DADG--WFDTGDLARIDADGYIRISGR-SKDVIIRGGEnIPVVE 456

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  919 IETRLLEQDSVREAVVVAQPGVA-GPTLVAYLVPTEAALVDAEsarqqELRSALKNSLLAVlpDYMvPAHMLLLENLPLT 997
Cdd:PRK13295   457 IEALLYRHPAIAQVAIVAYPDERlGERACAFVVPRPGQSLDFE-----EMVEFLKAQKVAK--QYI-PERLVVRDALPRT 528

                          570
                   ....*....|
gi 2183974163  998 PNGKINRKAL 1007
Cdd:PRK13295   529 PSGKIQKFRL 538

PRK08314

long-chain-fatty-acid--CoA ligase; Validated

501-1007

4.40e-39

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 236235 [Multi-domain] Cd Length: 546 Bit Score: 155.89 E-value: 4.40e-39

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  501 LPAS-EYPAGQGVHRLfEAQAGLTPDAPALLFGEERLSYAELNALANRLA-WRLREEGVGSDVLVGIALERGVPMVVALL 578
Cdd:PRK08314     1 LPKSlTLPETSLFHNL-EVSARRYPDKTAIVFYGRAISYRELLEEAERLAgYLQQECGVRKGDRVLLYMQNSPQFVIAYY 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  579 AVLKAGGAYVPLDPQYPADRLQYMIDDSGLRLLLSQQSVLARLPQ---SDGLQSLLL--------DDLERLVHGYPAENP 647
Cdd:PRK08314    80 AILRANAVVVPVNPMNREEELAHYVTDSGARVAIVGSELAPKVAPavgNLRLRHVIVaqysdylpAEPEIAVPAWLRAEP 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  648 DLPEA------------------------PDSLCYAIYTSGSTGQPKGVMVRHRALTNFVCSIARQPGMLARDRLLSVTT 703
Cdd:PRK08314   160 PLQALapggvvawkealaaglappphtagPDDLAVLPYTSGTTGVPKGCMHTHRTVMANAVGSVLWSNSTPESVVLAVLP 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  704 FsFDIFGLE--LYVPLARGASMLLASReqaQDPEALLDLVERQGVTVLQATPAtwrMLCD------SERVDLlrgCTLLC 775
Cdd:PRK08314   240 L-FHVTGMVhsMNAPIYAGATVVLMPR---WDREAAARLIERYRVTHWTNIPT---MVVDflaspgLAERDL---SSLRY 309

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  776 ---GGEALAEDLAARMRGLSASTW-NLYGPTETTiwsARFRLGEEARP---FLGGPLENTALYILDSEM-NPCPPGVAGE 847
Cdd:PRK08314   310 iggGGAAMPEAVAERLKELTGLDYvEGYGLTETM---AQTHSNPPDRPklqCLGIPTFGVDARVIDPETlEELPPGEVGE 386

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  848 LLIGGDGLARGYHRRPGLTAERFlpdpFAADGSRLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQD 927
Cdd:PRK08314   387 IVVHGPQVFKGYWNRPEATAEAF----IEIDGKRFFRTGDLGRMDEEGYFFITDRLKRMINASGFKVWPAEVENLLYKHP 462

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  928 SVREAVVVAQPGV-AGPTLVAYLV--PTEAALVDAES----ARQQelrsalknslLAVlpdYMVPAHMLLLENLPLTPNG 1000
Cdd:PRK08314   463 AIQEACVIATPDPrRGETVKAVVVlrPEARGKTTEEEiiawAREH----------MAA---YKYPRIVEFVDSLPKSGSG 529


                   ....*..
gi 2183974163 1001 KINRKAL 1007
Cdd:PRK08314   530 KILWRQL 536

EntE

COG1021

EntE, 2,3-dihydroxybenzoate-AMP synthase component of non-ribosomal peptide synthetase ...

509-1007

9.38e-39

EntE, 2,3-dihydroxybenzoate-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism];

Pssm-ID: 440644 [Multi-domain] Cd Length: 533 Bit Score: 154.53 E-value: 9.38e-39

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  509 GQGVHRLFEAQAGLTPDAPALLFGEERLSYAELNALANRLAWRLREEGV--GSDVLVgiALERGVPMVVALLAVLKAGGA 586
Cdd:COG1021     24 GETLGDLLRRRAERHPDRIAVVDGERRLSYAELDRRADRLAAGLLALGLrpGDRVVV--QLPNVAEFVIVFFALFRAGAI 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  587 YVPLdpqYPADR---LQYMIDDSGLRLLLSQ------------QSVLARLPqsdGLQSLLLD-------DLERLVHGyPA 644
Cdd:COG1021    102 PVFA---LPAHRraeISHFAEQSEAVAYIIPdrhrgfdyralaRELQAEVP---SLRHVLVVgdageftSLDALLAA-PA 174

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  645 ENPDLPEAPDSLCYAIYTSGSTGQPKGVMVRHRAltnFVCSI---ARQPGMLARDRLLSV-------TTFSFDIFGlely 714
Cdd:COG1021    175 DLSEPRPDPDDVAFFQLSGGTTGLPKLIPRTHDD---YLYSVrasAEICGLDADTVYLAAlpaahnfPLSSPGVLG---- 247

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  715 vPLARGASMLLASREqaqDPEALLDLVERQGVTVLQATPA---TWRMLCDSERVDL--LRgcTLLCGGEALAEDLAARMR 789
Cdd:COG1021    248 -VLYAGGTVVLAPDP---SPDTAFPLIERERVTVTALVPPlalLWLDAAERSRYDLssLR--VLQVGGAKLSPELARRVR 321

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  790 -GLSASTWNLYGPTETTIWSARFRLGEEARpflggplENTA---------LYILDSEMNPCPPGVAGELLIGGDGLARGY 859
Cdd:COG1021    322 pALGCTLQQVFGMAEGLVNYTRLDDPEEVI-------LTTQgrpispddeVRIVDEDGNPVPPGEVGELLTRGPYTIRGY 394

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  860 HRRPGLTAERFLPDPFaadgsrlYRTGDLARYRADGVIEYLGRIDHQVkIR-GFRIELGEIETRLLEQDSVREAVVVAQP 938
Cdd:COG1021    395 YRAPEHNARAFTPDGF-------YRTGDLVRRTPDGYLVVEGRAKDQI-NRgGEKIAAEEVENLLLAHPAVHDAAVVAMP 466

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  939 GVA-GPTLVAYLVPTEAALvdaesaRQQELRSALKNSLLAvlpDYMVPAHMLLLENLPLTPNGKINRKAL 1007
Cdd:COG1021    467 DEYlGERSCAFVVPRGEPL------TLAELRRFLRERGLA---AFKLPDRLEFVDALPLTAVGKIDKKAL 527

MACS_like_4

cd05969

Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); This family is most ...

536-1007

9.48e-39

Pssm-ID: 341273 [Multi-domain] Cd Length: 442 Bit Score: 152.27 E-value: 9.48e-39

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  536 LSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQYMIDDSGLRLLLSQQ 615
Cdd:cd05969      1 YTFAQLKVLSARFANVLKSLGVGKGDRVFVLSPRSPELYFSMLGIGKIGAVICPLFSAFGPEAIRDRLENSEAKVLITTE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  616 SVLARLPQSDGLqslllddlerLVHgypaenpdlpeapdslcyaiYTSGSTGQPKGVMVRHRALTNFVCSIARQPGMLAR 695
Cdd:cd05969     81 ELYERTDPEDPT----------LLH--------------------YTSGTTGTPKGVLHVHDAMIFYYFTGKYVLDLHPD 130

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  696 DRLLS------VTTFSFDIFGlelyvPLARGASMLlaSREQAQDPEALLDLVERQGVTVLQATPATWRMLCDS-----ER 764
Cdd:cd05969    131 DIYWCtadpgwVTGTVYGIWA-----PWLNGVTNV--VYEGRFDAESWYGIIERVKVTVWYTAPTAIRMLMKEgdelaRK 203

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  765 VDL--LRgcTLLCGGEAL-AEDLAARMRGLSASTWNLYGPTET-TIWSARFrLGEEARP-FLGGPLENTALYILDSEMNP 839
Cdd:cd05969    204 YDLssLR--FIHSVGEPLnPEAIRWGMEVFGVPIHDTWWQTETgSIMIANY-PCMPIKPgSMGKPLPGVKAAVVDENGNE 280

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  840 CPPGVAGELLIGGD--GLARGYHRRPGLTAERFLpdpfaaDGsrLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELG 917
Cdd:cd05969    281 LPPGTKGILALKPGwpSMFRGIWNDEERYKNSFI------DG--WYLTGDLAYRDEDGYFWFVGRADDIIKTSGHRVGPF 352

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  918 EIETRLLEQDSVREAVVVAQPG-VAGPTLVAYLVPTEAalVDAESARQQELRSALKNSLLAvlpdYMVPAHMLLLENLPL 996
Cdd:cd05969    353 EVESALMEHPAVAEAGVIGKPDpLRGEIIKAFISLKEG--FEPSDELKEEIINFVRQKLGA----HVAPREIEFVDNLPK 426

                          490
                   ....*....|.
gi 2183974163  997 TPNGKINRKAL 1007
Cdd:cd05969    427 TRSGKIMRRVL 437

PRK07798

acyl-CoA synthetase; Validated

515-1001

1.13e-38

acyl-CoA synthetase; Validated

Pssm-ID: 236100 [Multi-domain] Cd Length: 533 Bit Score: 154.27 E-value: 1.13e-38

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  515 LFEAQAGLTPDAPALLFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQY 594
Cdd:PRK07798     8 LFEAVADAVPDRVALVCGDRRLTYAELEERANRLAHYLIAQGLGPGDHVGIYARNRIEYVEAMLGAFKARAVPVNVNYRY 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  595 PADRLQYMIDDSGLRLLLSQQS-------VLARLPQ-------SDGLQSLLLD---DLERLVHGYPAENPDLPEAPDSLc 657
Cdd:PRK07798    88 VEDELRYLLDDSDAVALVYEREfaprvaeVLPRLPKlrtlvvvEDGSGNDLLPgavDYEDALAAGSPERDFGERSPDDL- 166

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  658 YAIYTSGSTGQPKGVMVRHraltnfvcSIARQPGMLARDRLLS--------VTTFSFDIFGLELYV--PLARGASMLLA- 726
Cdd:PRK07798   167 YLLYTGGTTGMPKGVMWRQ--------EDIFRVLLGGRDFATGepiedeeeLAKRAAAGPGMRRFPapPLMHGAGQWAAf 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  727 -----------SREQAQDPEALLDLVERQGVTVLQAT-PATWRMLCDS----ERVDLLRGCTLLCGGEALAEDLAARMRG 790
Cdd:PRK07798   239 aalfsgqtvvlLPDVRFDADEVWRTIEREKVNVITIVgDAMARPLLDAlearGPYDLSSLFAIASGGALFSPSVKEALLE 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  791 L--SASTWNLYGPTET----TIWSARFRLGEEARPFLGGPleNTALyiLDSEMNPCPPGvagellIGGDG-LAR------ 857
Cdd:PRK07798   319 LlpNVVLTDSIGSSETgfggSGTVAKGAVHTGGPRFTIGP--RTVV--LDEDGNPVEPG------SGEIGwIARrghipl 388

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  858 GYHRRPGLTAERFlpdpFAADGSRLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQ 937
Cdd:PRK07798   389 GYYKDPEKTAETF----PTIDGVRYAIPGDRARVEADGTITLLGRGSVCINTGGEKVFPEEVEEALKAHPDVADALVVGV 464

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2183974163  938 PGVA-GPTLVAYLVPTEAALVDAEsarqqELRSALKNSLLAvlpdYMVPAHMLLLENLPLTPNGK 1001
Cdd:PRK07798   465 PDERwGQEVVAVVQLREGARPDLA-----ELRAHCRSSLAG----YKVPRAIWFVDEVQRSPAGK 520

PRK05605

long-chain-fatty-acid--CoA ligase; Validated

502-1005

2.02e-38

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 235531 [Multi-domain] Cd Length: 573 Bit Score: 154.39 E-value: 2.02e-38

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  502 PAS-EYPAGQGVHrLFEAQAGLTPDAPALLFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAV 580
Cdd:PRK05605    24 PHDlDYGDTTLVD-LYDNAVARFGDRPALDFFGATTTYAELGKQVRRAAAGLRALGVRPGDRVAIVLPNCPQHIVAFYAV 102

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  581 LKAGGAYVPLDPQYPADRLQYMIDDSGLRLLL---SQQSVLARLPQSDGLQSLLLDDL---------------------- 635
Cdd:PRK05605   103 LRLGAVVVEHNPLYTAHELEHPFEDHGARVAIvwdKVAPTVERLRRTTPLETIVSVNMiaampllqrlalrlpipalrka 182

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  636 --------------ERLVH---GYPAENPDLPE-APDSLCYAIYTSGSTGQPKGVMVRHRAL-TNFVCSIARQPGMLARD 696
Cdd:PRK05605   183 raaltgpapgtvpwETLVDaaiGGDGSDVSHPRpTPDDVALILYTSGTTGKPKGAQLTHRNLfANAAQGKAWVPGLGDGP 262

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  697 -RLLSVTTFsFDIFGLELYVPLAR--GASMLLASREqaqDPEALLDLVERQGVTVLQATPATWRMLCDS---ERVDLLRG 770
Cdd:PRK05605   263 eRVLAALPM-FHAYGLTLCLTLAVsiGGELVLLPAP---DIDLILDAMKKHPPTWLPGVPPLYEKIAEAaeeRGVDLSGV 338

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  771 CTLLCGGEALAEDLAARMRGLSAStwNL---YGPTETTIWSARFRLGEEARP-FLGGPLENTALYILDSEmNPC---PPG 843
Cdd:PRK05605   339 RNAFSGAMALPVSTVELWEKLTGG--LLvegYGLTETSPIIVGNPMSDDRRPgYVGVPFPDTEVRIVDPE-DPDetmPDG 415

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  844 VAGELLIGGDGLARGYHRRPGLTAERFLPDpfaadgsrLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRL 923
Cdd:PRK05605   416 EEGELLVRGPQVFKGYWNRPEETAKSFLDG--------WFRTGDVVVMEEDGFIRIVDRIKELIITGGFNVYPAEVEEVL 487

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  924 LEQDSVREAVVVAQPGVAGP-TLVAYLVPTEAALVDAESarqqeLRSALKNSLLAvlpdYMVPAHMLLLENLPLTPNGKI 1002
Cdd:PRK05605   488 REHPGVEDAAVVGLPREDGSeEVVAAVVLEPGAALDPEG-----LRAYCREHLTR----YKVPRRFYHVDELPRDQLGKV 558


                   ...
gi 2183974163 1003 NRK 1005
Cdd:PRK05605   559 RRR 561

ttLC_FACS_AlkK_like

cd12119

Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; This family includes ...

1573-2071

2.56e-38

Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; This family includes fatty acyl-CoA synthetases that can activate medium-chain to long-chain fatty acids. They catalyze the ATP-dependent acylation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. The fatty acyl-CoA synthetases are responsible for fatty acid degradation as well as physiological regulation of cellular functions via the production of fatty acyl-CoA esters. The fatty acyl-CoA synthetase from Thermus thermophiles in this family catalyzes the long-chain fatty acid, myristoyl acid, while another member in this family, the AlkK protein identified from Pseudomonas oleovorans, targets medium chain fatty acids. This family also includes uncharacterized FACS proteins.

Pssm-ID: 341284 [Multi-domain] Cd Length: 518 Bit Score: 152.78 E-value: 2.56e-38

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1573 LIERQAAERPRATaVVY-----GERALDYGELNLRANRLAHRLIELGVGPDVLVGLAA---ERSLEMivgLLAILKAGGA 1644
Cdd:cd12119      1 LLEHAARLHGDRE-IVSrthegEVHRYTYAEVAERARRLANALRRLGVKPGDRVATLAwntHRHLEL---YYAVPGMGAV 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1645 YVPLDPRYPSDRLGYMIEDSGIRLLLTQR-------AARERLPLGEGLPCL-------------------LLDAEHEWAG 1698
Cdd:cd12119     77 LHTINPRLFPEQIAYIINHAEDRVVFVDRdflplleAIAPRLPTVEHVVVMtddaampepagvgvlayeeLLAAESPEYD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1699 YPESDpqsavgvDNLAYVI-YTSGSTGKPKGTLLPH-GNVL-----RLFDAtrhwFGFSADDAW----SLFHSYAfdfsv 1767
Cdd:cd12119    157 WPDFD-------ENTAAAIcYTSGTTGNPKGVVYSHrSLVLhamaaLLTDG----LGLSESDVVlpvvPMFHVNA----- 220

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1768 WEI-FGALLHGGRLVIV-PYEtsrSPEDFLRLLCRERVTVLNQTPSAFKQLMQ-VACAGQEVPPLalRHVVFGGEALEvQ 1844
Cdd:cd12119    221 WGLpYAAAMVGAKLVLPgPYL---DPASLAELIEREGVTFAAGVPTVWQGLLDhLEANGRDLSSL--RRVVIGGSAVP-R 294

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1845 ALRPWFErfgDRAPRLVNMYGITETT--VHVTYRPLSLADLDGGAA----SPIGEPIPDLSWYLLDAGLNPVPR--GCIG 1916
Cdd:cd12119    295 SLIEAFE---ERGVRVIHAWGMTETSplGTVARPPSEHSNLSEDEQlalrAKQGRPVPGVELRIVDDDGRELPWdgKAVG 371

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1917 ELYVGGAGLARGYLNRPElsctrfvADPFSTTGGRLyRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQ 1996
Cdd:cd12119    372 ELQVRGPWVTKSYYKNDE-------ESEALTEDGWL-RTGDVATIDEDGYLTITDRSKDVIKSGGEWISSVELENAIMAH 443

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2183974163 1997 PGVAEAVVL--PHEGPGATQLVGYVVTQAAPSDPAALRDTLRQALkaslPEHMVPAHLLFLERLPLTANGKLDRRAL 2071
Cdd:cd12119    444 PAVAEAAVIgvPHPKWGERPLAVVVLKEGATVTAEELLEFLADKV----AKWWLPDDVVFVDEIPKTSTGKIDKKAL 516

A_NRPS_Srf_like

cd12117

The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis ...

3089-3183

2.76e-38

Pssm-ID: 341282 [Multi-domain] Cd Length: 483 Bit Score: 151.97 E-value: 2.76e-38

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3089 RLFEEQVERTPTAPALAFGEERLDYAELNRRANRLAHALIERGIGADRLVGVAMERSIEMVVALMAILKAGGAYVPVDPE 3168
Cdd:cd12117      1 ELFEEQAARTPDAVAVVYGDRSLTYAELNERANRLARRLRAAGVGPGDVVGVLAERSPELVVALLAVLKAGAAYVPLDPE 80

                           90
                   ....*....|....*
gi 2183974163 3169 YPEERQAYMLEDSGV 3183
Cdd:cd12117     81 LPAERLAFMLADAGA 95

VL_LC_FACS_like

cd05907

Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA ...

536-1007

4.67e-38

Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; This family includes long-chain fatty acid (C12-C20) CoA synthetases and Bubblegum-like very long-chain (>C20) fatty acid CoA synthetases. FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Eukaryotes generally have multiple isoforms of LC-FACS genes with multiple splice variants. For example, nine genes are found in Arabidopsis and six genes are expressed in mammalian cells. Drosophila melanogaster mutant bubblegum (BGM) have elevated levels of very-long-chain fatty acids (VLCFA) caused by a defective gene later named bubblegum. The human homolog (hsBG) of bubblegum has been characterized as a very long chain fatty acid CoA synthetase that functions specifically in the brain; hsBG may play a central role in brain VLCFA metabolism and myelinogenesis. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.

Pssm-ID: 341233 [Multi-domain] Cd Length: 452 Bit Score: 150.44 E-value: 4.67e-38

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  536 LSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQYMIDDSGLRLLLSqq 615
Cdd:cd05907      6 ITWAEFAEEVRALAKGLIALGVEPGDRVAILSRNRPEWTIADLAILAIGAVPVPIYPTSSAEQIAYILNDSEAKALFV-- 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  616 svlarlpqsdglqslllddlerlvhgypaenpdlpEAPDSLCYAIYTSGSTGQPKGVMVRHRALTNFVCSIARQPGMLAR 695
Cdd:cd05907     84 -----------------------------------EDPDDLATIIYTSGTTGRPKGVMLSHRNILSNALALAERLPATEG 128

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  696 DRLLSVTTFSFdIFGLE--LYVPLARGASMLLASreqaqDPEALLDLVERQGVTVLQATPATWRMLCDSERVDL---LRG 770
Cdd:cd05907    129 DRHLSFLPLAH-VFERRagLYVPLLAGARIYFAS-----SAETLLDDLSEVRPTVFLAVPRVWEKVYAAIKVKAvpgLKR 202

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  771 CTLL-----------CGGEALAEDLAARMRGLSASTWNLYGPTET----TIWSA-RFRLGEearpfLGGPLENTALYIld 834
Cdd:cd05907    203 KLFDlavggrlrfaaSGGAPLPAELLHFFRALGIPVYEGYGLTETsavvTLNPPgDNRIGT-----VGKPLPGVEVRI-- 275

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  835 semnpcppGVAGELLIGGDGLARGYHRRPGLTAERFLPDPFaadgsrlYRTGDLARYRADGVIEYLGRI-DHQVKIRGFR 913
Cdd:cd05907    276 --------ADDGEILVRGPNVMLGYYKNPEATAEALDADGW-------LHTGDLGEIDEDGFLHITGRKkDLIITSGGKN 340

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  914 IELGEIETRLLEQDSVREAVVVAQpgvAGPTLVAYLVPTEAALVD------------AESARQQELRSALK---NSLLAV 978
Cdd:cd05907    341 ISPEPIENALKASPLISQAVVIGD---GRPFLVALIVPDPEALEAwaeehgiaytdvAELAANPAVRAEIEaavEAANAR 417

                          490       500       510
                   ....*....|....*....|....*....|....*
gi 2183974163  979 LPDYMVPAHMLLL------ENLPLTPNGKINRKAL 1007
Cdd:cd05907    418 LSRYEQIKKFLLLpepftiENGELTPTLKLKRPVI 452

PRK06188

acyl-CoA synthetase; Validated

1565-2074

6.26e-38

acyl-CoA synthetase; Validated

Pssm-ID: 235731 [Multi-domain] Cd Length: 524 Bit Score: 151.68 E-value: 6.26e-38

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1565 TPASCLHR------LIERQAAERPRATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAI 1638
Cdd:PRK06188     3 TMADLLHSgatyghLLVSALKRYPDRPALVLGDTRLTYGQLADRISRYIQAFEALGLGTGDAVALLSLNRPEVLMAIGAA 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1639 LKAGGAYVPLDPRYPSDRLGYMIEDSGIRLLLTQRAA-RER-LPLGEGLPCLLL--------DAEHEWAGYPESDPQSAV 1708
Cdd:PRK06188    83 QLAGLRRTALHPLGSLDDHAYVLEDAGISTLIVDPAPfVERaLALLARVPSLKHvltlgpvpDGVDLLAAAAKFGPAPLV 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1709 GVD---NLAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRHWFGFSADD----AWSLFHSYAFDFSVweifgALLHGGRLV 1781
Cdd:PRK06188   163 AAAlppDIAGLAYTGGTTGKPKGVMGTHRSIATMAQIQLAEWEWPADPrflmCTPLSHAGGAFFLP-----TLLRGGTVI 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1782 IVPyetSRSPEDFLRLLCRERVTVLNQTPSAFKQLMqvacagqEVPPLA------LRHVVFGGEALEVQALRPWFERFGd 1855
Cdd:PRK06188   238 VLA---KFDPAEVLRAIEEQRITATFLVPTMIYALL-------DHPDLRtrdlssLETVYYGASPMSPVRLAEAIERFG- 306

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1856 raPRLVNMYGITETTVHVTYrpLSLADLDGGAA---SPIGEPIPDLSWYLLDAGLNPVPRGCIGELYVGGAGLARGYLNR 1932
Cdd:PRK06188   307 --PIFAQYYGQTEAPMVITY--LRKRDHDPDDPkrlTSCGRPTPGLRVALLDEDGREVAQGEVGEICVRGPLVMDGYWNR 382

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1933 PELSCTRFvadpfstTGGRLyRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVVL--PHE-- 2008
Cdd:PRK06188   383 PEETAEAF-------RDGWL-HTGDVAREDEDGFYYIVDRKKDMIVTGGFNVFPREVEDVLAEHPAVAQVAVIgvPDEkw 454

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2183974163 2009 GPGATQLVgyVVTQAAPSDPAALRDTLRQAlKASlpeHMVPAHLLFLERLPLTANGKLDRRALPAP 2074
Cdd:PRK06188   455 GEAVTAVV--VLRPGAAVDAAELQAHVKER-KGS---VHAPKQVDFVDSLPLTALGKPDKKALRAR 514

PRK09088

acyl-CoA synthetase; Validated

519-1007

7.35e-38

acyl-CoA synthetase; Validated

Pssm-ID: 181644 [Multi-domain] Cd Length: 488 Bit Score: 150.73 E-value: 7.35e-38

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  519 QAGLTPDAPAL--LFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPA 596
Cdd:PRK09088     4 HARLQPQRLAAvdLALGRRWTYAELDALVGRLAAVLRRRGCVDGERLAVLARNSVWLVALHFACARVGAIYVPLNWRLSA 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  597 DRLQYMIDDSGLRLLLSQQSvlarlPQSDGLQSLLLDDLERLVHGY-PAENPDLPeaPDSLCYAIYTSGSTGQPKGVMVR 675
Cdd:PRK09088    84 SELDALLQDAEPRLLLGDDA-----VAAGRTDVEDLAAFIASADALePADTPSIP--PERVSLILFTSGTSGQPKGVMLS 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  676 HRALTNFVCSIARQPGMLARDRLLsVTTFSFDIFGLELYV--PLARGASMLLASreqAQDPEALLDLVERQ--GVTVLQA 751
Cdd:PRK09088   157 ERNLQQTAHNFGVLGRVDAHSSFL-CDAPMFHIIGLITSVrpVLAVGGSILVSN---GFEPKRTLGRLGDPalGITHYFC 232

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  752 TPATWRMLCDSERVD--LLRGCTLLCGGEA--LAEDLAARMR---------GLSASTWNLYGPTETTIWSARfrLGEEar 818
Cdd:PRK09088   233 VPQMAQAFRAQPGFDaaALRHLTALFTGGAphAAEDILGWLDdgipmvdgfGMSEAGTVFGMSVDCDVIRAK--AGAA-- 308

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  819 pflGGPLENTALYILDSEMNPCPPGVAGELLIGGDGLARGYHRRPGLTAERFlpdpfaaDGSRLYRTGDLARYRADGVIE 898
Cdd:PRK09088   309 ---GIPTPTVQTRVVDDQGNDCPAGVPGELLLRGPNLSPGYWRRPQATARAF-------TGDGWFRTGDIARRDADGFFW 378

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  899 YLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQPGVA-GPTLVAYLVPTEAALVDAEsarqqELRSALKnsllA 977
Cdd:PRK09088   379 VVDRKKDMFISGGENVYPAEIEAVLADHPGIRECAVVGMADAQwGEVGYLAIVPADGAPLDLE-----RIRSHLS----T 449

                          490       500       510
                   ....*....|....*....|....*....|
gi 2183974163  978 VLPDYMVPAHMLLLENLPLTPNGKINRKAL 1007
Cdd:PRK09088   450 RLAKYKVPKHLRLVDALPRTASGKLQKARL 479

ABCL

cd05958

2-aminobenzoate-CoA ligase (ABCL); ABCL catalyzes the initial step in the 2-aminobenzoate ...

526-1007

1.46e-37

Pssm-ID: 341268 [Multi-domain] Cd Length: 439 Bit Score: 148.78 E-value: 1.46e-37

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  526 APALLFGEERLSYAELNALANRLAWRLREEGV---GSDVLvgIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQYM 602
Cdd:cd05958      1 RTCLRSPEREWTYRDLLALANRIANVLVGELGivpGNRVL--LRGSNSPELVACWFGIQKAGAIAVATMPLLRPKELAYI 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  603 IDDSGLRLLLSQQSVLARlpqsdglqslllddlerlvhgypaenpdlpeapDSLCYAIYTSGSTGQPKGVMVRHRALTNF 682
Cdd:cd05958     79 LDKARITVALCAHALTAS---------------------------------DDICILAFTSGTTGAPKATMHFHRDPLAS 125

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  683 VCSIARQP-GMLARDRLLSVTTFSFDI-FGLELYVPLARGASMLLASREQAQDpeaLLDLVERQGVTVLQATPATWR-ML 759
Cdd:cd05958    126 ADRYAVNVlRLREDDRFVGSPPLAFTFgLGGVLLFPFGVGASGVLLEEATPDL---LLSAIARYKPTVLFTAPTAYRaML 202

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  760 CDSERVDLLRGCTLLC--GGEALAEDLAARMRGLSAS-TWNLYGPTET--TIWSARfrlGEEARP-FLGGPLENTALYIL 833
Cdd:cd05958    203 AHPDAAGPDLSSLRKCvsAGEALPAALHRAWKEATGIpIIDGIGSTEMfhIFISAR---PGDARPgATGKPVPGYEAKVV 279

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  834 DSEMNPCPPGVAGELLIGGDglargyhrrpglTAERFLPDPFAA---DGSRLYrTGDLARYRADGVIEYLGRIDHQVKIR 910
Cdd:cd05958    280 DDEGNPVPDGTIGRLAVRGP------------TGCRYLADKRQRtyvQGGWNI-TGDTYSRDPDGYFRHQGRSDDMIVSG 346

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  911 GFRIELGEIETRLLEQDSVREAVVVAQPGVAGPTLV-AYLVPTEAALVDAESARQqelrsaLKNSLLAVLPDYMVPAHML 989
Cdd:cd05958    347 GYNIAPPEVEDVLLQHPAVAECAVVGHPDESRGVVVkAFVVLRPGVIPGPVLARE------LQDHAKAHIAPYKYPRAIE 420

                          490
                   ....*....|....*...
gi 2183974163  990 LLENLPLTPNGKINRKAL 1007
Cdd:cd05958    421 FVTELPRTATGKLQRFAL 438

A_NRPS

cd05930

The adenylation domain of nonribosomal peptide synthetases (NRPS); The adenylation (A) domain ...

3099-3183

2.18e-37

Pssm-ID: 341253 [Multi-domain] Cd Length: 444 Bit Score: 148.44 E-value: 2.18e-37

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3099 PTAPALAFGEERLDYAELNRRANRLAHALIERGIGADRLVGVAMERSIEMVVALMAILKAGGAYVPVDPEYPEERQAYML 3178
Cdd:cd05930      1 PDAVAVVDGDQSLTYAELDARANRLARYLRERGVGPGDLVAVLLERSLEMVVAILAVLKAGAAYVPLDPSYPAERLAYIL 80


                   ....*
gi 2183974163 3179 EDSGV 3183
Cdd:cd05930     81 EDSGA 85

MACS_like_2

cd05973

Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the ...

1594-2071

2.67e-37

Pssm-ID: 341277 [Multi-domain] Cd Length: 437 Bit Score: 148.05 E-value: 2.67e-37

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1594 LDYGELNLRANRLAHRLIELGVGP-DVLVGLAAeRSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGYMIEDSGIRLLLTQ 1672
Cdd:cd05973      1 LTFGELRALSARFANALQELGVGPgDVVAGLLP-RTPELVVTILGIWRLGAVYQPLFTAFGPKAIEHRLRTSGARLVVTD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1673 RAARERLPlgeglpcllldaehewagypesdpqsavgvDNLAYVIYTSGSTGKPKGTLLP------HGNVLR----LFDA 1742
Cdd:cd05973     80 AANRHKLD------------------------------SDPFVMMFTSGTTGLPKGVPVPlralaaFGAYLRdavdLRPE 129

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1743 TRHWFgfSADDAWSLFHSYAfdfsvweIFGALLHGGRLVIvpYETSRSPEDFLRLLCRERVTVLNQTPSAFKQLMQVACA 1822
Cdd:cd05973    130 DSFWN--AADPGWAYGLYYA-------ITGPLALGHPTIL--LEGGFSVESTWRVIERLGVTNLAGSPTAYRLLMAAGAE 198

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1823 GQEVPPLALRHVVFGGEALEVQALRpWFerfGDRAPRLV-NMYGITETTV-----HVTYRPLSladldggaASPIGEPIP 1896
Cdd:cd05973    199 VPARPKGRLRRVSSAGEPLTPEVIR-WF---DAALGVPIhDHYGQTELGMvlanhHALEHPVH--------AGSAGRAMP 266

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1897 DLSWYLLDAGLNPVPRGCIGELYVGGAglargylNRPELSCTRFVADPFSTTGGRLYRTGDLARYRCDGVVEYVGRIDHQ 1976
Cdd:cd05973    267 GWRVAVLDDDGDELGPGEPGRLAIDIA-------NSPLMWFRGYQLPDTPAIDGGYYLTGDTVEFDPDGSFSFIGRADDV 339

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1977 VKIRGFRIELGEIEARLLAQPGVAEAVVLPHEGPGATQLV-GYVVTQAAPSDPAALRDTLRQALKASLPEHMVPAHLLFL 2055
Cdd:cd05973    340 ITMSGYRIGPFDVESALIEHPAVAEAAVIGVPDPERTEVVkAFVVLRGGHEGTPALADELQLHVKKRLSAHAYPRTIHFV 419

                          490
                   ....*....|....*.
gi 2183974163 2056 ERLPLTANGKLDRRAL 2071
Cdd:cd05973    420 DELPKTPSGKIQRFLL 435

PRK08316

acyl-CoA synthetase; Validated

1573-2071

1.67e-36

acyl-CoA synthetase; Validated

Pssm-ID: 181381 [Multi-domain] Cd Length: 523 Bit Score: 147.39 E-value: 1.67e-36

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1573 LIERQAAERPRATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRY 1652
Cdd:PRK08316    16 ILRRSARRYPDKTALVFGDRSWTYAELDAAVNRVAAALLDLGLKKGDRVAALGHNSDAYALLWLACARAGAVHVPVNFML 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1653 PSDRLGYMIEDSGIRLLLTQRAARERLP--------LGEGLPCLLLDAEHE--------WA-GYPESDPQSAVGVDNLAY 1715
Cdd:PRK08316    96 TGEELAYILDHSGARAFLVDPALAPTAEaalallpvDTLILSLVLGGREAPggwldfadWAeAGSVAEPDVELADDDLAQ 175

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1716 VIYTSGSTGKPKGTLLPHGNVLRLFDATRHWFGFSADD----AWSLFHSYAFDfsvweIF--GALLHGGRLVIVPyetSR 1789
Cdd:PRK08316   176 ILYTSGTESLPKGAMLTHRALIAEYVSCIVAGDMSADDiplhALPLYHCAQLD-----VFlgPYLYVGATNVILD---AP 247

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1790 SPEDFLRLLCRERVTVLNQTPSAFKQLmqvacagqevpplaLRHVVFggEALEVQALR-----------PWFERFGDRAP 1858
Cdd:PRK08316   248 DPELILRTIEAERITSFFAPPTVWISL--------------LRHPDF--DTRDLSSLRkgyygasimpvEVLKELRERLP 311

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1859 --RLVNMYGITE----TTVhvtyrpLSLADLDGGAASPiGEPIPDLSWYLLDAGLNPVPRGCIGELYVGGAGLARGYLNR 1932
Cdd:PRK08316   312 glRFYNCYGQTEiaplATV------LGPEEHLRRPGSA-GRPVLNVETRVVDDDGNDVAPGEVGEIVHRSPQLMLGYWDD 384

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1933 PELSctrfvADPFSttGGrLYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVV--LPHE-- 2008
Cdd:PRK08316   385 PEKT-----AEAFR--GG-WFHSGDLGVMDEEGYITVVDRKKDMIKTGGENVASREVEEALYTHPAVAEVAVigLPDPkw 456

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2183974163 2009 GPGATQLVgyVVTQAAPSDPAALRDTLRQALKAslpeHMVPAHLLFLERLPLTANGKLDRRAL 2071
Cdd:PRK08316   457 IEAVTAVV--VPKAGATVTEDELIAHCRARLAG----FKVPKRVIFVDELPRNPSGKILKREL 513

LC_FACS_like

cd05935

Putative long-chain fatty acid CoA ligase; The members of this family are putative long-chain ...

1594-2071

1.88e-36

Pssm-ID: 341258 [Multi-domain] Cd Length: 430 Bit Score: 145.31 E-value: 1.88e-36

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1594 LDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGYMIEDSGIRLLLTQR 1673
Cdd:cd05935      2 LTYLELLEVVKKLASFLSNKGVRKGDRVGICLQNSPQYVIAYFAIWRANAVVVPINPMLKERELEYILNDSGAKVAVVGS 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1674 AarerlplgeglpcllldaehewagypesdpqsavgVDNLAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRHWFGFSADD 1753
Cdd:cd05935     82 E-----------------------------------LDDLALIPYTSGTTGLPKGCMHTHFSAAANALQSAVWTGLTPSD 126

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1754 ----AWSLFHSYAFDFSVweiFGALLHGGRLVIVpyetSRSPEDFLR-LLCRERVTVLNQTPSAFKQLMqvACAGQEVPP 1828
Cdd:cd05935    127 vilaCLPLFHVTGFVGSL---NTAVYVGGTYVLM----ARWDRETALeLIEKYKVTFWTNIPTMLVDLL--ATPEFKTRD 197

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1829 LALRHVVFGGEALEVQALRpwfERFGDRAP-RLVNMYGITETTVHVTYRPLSLADLdggaaSPIGEPIPDLSWYLLDA-G 1906
Cdd:cd05935    198 LSSLKVLTGGGAPMPPAVA---EKLLKLTGlRFVEGYGLTETMSQTHTNPPLRPKL-----QCLGIP*FGVDARVIDIeT 269

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1907 LNPVPRGCIGELYVGGAGLARGYLNRPELSCTRFVADpfstTGGRLYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIEL 1986
Cdd:cd05935    270 GRELPPNEVGEIVVRGPQIFKGYWNRPEETEESFIEI----KGRRFFRTGDLGYMDEEGYFFFVDRVKRMINVSGFKVWP 345

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1987 GEIEARLLAQPGVAEAVVL--PHEGPGATqLVGYVVTQAAPSDPAALRDTLRQAlKASLPEHMVPAHLLFLERLPLTANG 2064
Cdd:cd05935    346 AEVEAKLYKHPAI*EVCVIsvPDERVGEE-VKAFIVLRPEYRGKVTEEDIIEWA-REQMAAYKYPREVEFVDELPRSASG 423


                   ....*..
gi 2183974163 2065 KLDRRAL 2071
Cdd:cd05935    424 KILWRLL 430

CBAL

cd05923

4-Chlorobenzoate-CoA ligase (CBAL); CBAL catalyzes the conversion of 4-chlorobenzoate (4-CB) ...

1570-2071

2.04e-36

4-Chlorobenzoate-CoA ligase (CBAL); CBAL catalyzes the conversion of 4-chlorobenzoate (4-CB) to 4-chlorobenzoyl-coenzyme A (4-CB-CoA) by the two-step adenylation and thioester-forming reactions. 4-Chlorobenzoate (4-CBA) is an environmental pollutant derived from microbial breakdown of aromatic pollutants, such as polychlorinated biphenyls (PCBs), DDT, and certain herbicides. The 4-CBA degrading pathway converts 4-CBA to the metabolite 4-hydroxybezoate (4-HBA), allowing some soil-dwelling microbes to utilize 4-CBA as an alternate carbon source. This pathway consists of three chemical steps catalyzed by 4-CBA-CoA ligase, 4-CBA-CoA dehalogenase, and 4HBA-CoA thioesterase in sequential reactions.

Pssm-ID: 341247 [Multi-domain] Cd Length: 493 Bit Score: 146.50 E-value: 2.04e-36

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1570 LHRLIERQAAERPRATAVVYGERALD--YGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVP 1647
Cdd:cd05923      3 VFEMLRRAASRAPDACAIADPARGLRltYSELRARIEAVAARLHARGLRPGQRVAVVLPNSVEAVIALLALHRLGAVPAL 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1648 LDPRYPSDRLGYMIEDSGIRLLLTQRAARERLPLGEGLPCLLL------DAEHEWAGYPESDPQSAVGVDnlAYVIYTSG 1721
Cdd:cd05923     83 INPRLKAAELAELIERGEMTAAVIAVDAQVMDAIFQSGVRVLAlsdlvgLGEPESAGPLIEDPPREPEQP--AFVFYTSG 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1722 STGKPKGTLLPHGNVLR--LFDAT----RHWFGFSADDAWSLFHSYAFdFSVweIFGALLHGGRLVIVPYEtsrSPEDFL 1795
Cdd:cd05923    161 TTGLPKGAVIPQRAAESrvLFMSTqaglRHGRHNVVLGLMPLYHVIGF-FAV--LVAALALDGTYVVVEEF---DPADAL 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1796 RLLCRERVTVLNQTPSAFKQLM-QVACAGQEVPplALRHVVFGGEALEVQALrpwfERFGDRAP-RLVNMYGITEttvhv 1873
Cdd:cd05923    235 KLIEQERVTSLFATPTHLDALAaAAEFAGLKLS--SLRHVTFAGATMPDAVL----ERVNQHLPgEKVNIYGTTE----- 303

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1874 TYRPLSLADLDGGAA-----------SPIGEPIPDLswylldaglnpVPRGCIGELYVGGAGLA--RGYLNRPELSCTRF 1940
Cdd:cd05923    304 AMNSLYMRDARTGTEmrpgffsevriVRIGGSPDEA-----------LANGEEGELIVAAAADAafTGYLNQPEATAKKL 372

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1941 VAdpfsttggRLYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVV--LPHEGPGATQLVGY 2018
Cdd:cd05923    373 QD--------GWYRTGDVGYVDPSGDVRILGRVDDMIISGGENIHPSEIERVLSRHPGVTEVVVigVADERWGQSVTACV 444

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2183974163 2019 VVTQAAPSDpaalrDTLRQALKAS-LPEHMVPAHLLFLERLPLTANGKLDRRAL 2071
Cdd:cd05923    445 VPREGTLSA-----DELDQFCRASeLADFKRPRRYFFLDELPKNAMNKVLRRQL 493

MACS_AAE_MA_like

cd05970

Medium-chain acyl-CoA synthetase (MACS) of AAE_MA like; MACS catalyzes the two-step activation ...

517-1007

2.94e-36

Medium-chain acyl-CoA synthetase (MACS) of AAE_MA like; MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This family of MACS enzymes is found in archaea and bacteria. It is represented by the acyl-adenylating enzyme from Methanosarcina acetivorans (AAE_MA). AAE_MA is most active with propionate, butyrate, and the branched analogs: 2-methyl-propionate, butyrate, and pentanoate. The specific activity is weaker for smaller or larger acids.

Pssm-ID: 341274 [Multi-domain] Cd Length: 537 Bit Score: 146.87 E-value: 2.94e-36

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  517 EAQAGLTPDAPALLF----GEER-LSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLD 591
Cdd:cd05970     24 DAMAKEYPDKLALVWcddaGEERiFTFAELADYSDKTANFFKAMGIGKGDTVMLTLKRRYEFWYSLLALHKLGAIAIPAT 103

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  592 PQYPADRLQYMIDDSGLRLLLS------QQSVLARLPQSDGLQSLLL---------DDLERLVHGYPaenPDL--PEAPD 654
Cdd:cd05970    104 HQLTAKDIVYRIESADIKMIVAiaedniPEEIEKAAPECPSKPKLVWvgdpvpegwIDFRKLIKNAS---PDFerPTANS 180

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  655 SLC-----YAIYTSGSTGQPKgvMVRHR---ALTNFVCSIARQpGMLARDRLLSV--TTFSFDIFGlELYVPLARGASML 724
Cdd:cd05970    181 YPCgedilLVYFSSGTTGMPK--MVEHDftyPLGHIVTAKYWQ-NVREGGLHLTVadTGWGKAVWG-KIYGQWIAGAAVF 256

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  725 LASREQAqDPEALLDLVERQGVTVLQATPATWRMLC--DSERVDL--LRGCTLlcGGEALAEDLAARMRGLSA-STWNLY 799
Cdd:cd05970    257 VYDYDKF-DPKALLEKLSKYGVTTFCAPPTIYRFLIreDLSRYDLssLRYCTT--AGEALNPEVFNTFKEKTGiKLMEGF 333

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  800 GPTETTIWSARFRlGEEARP-FLGGPLENTALYILDSEMNPCPPGVAGELLIGGD-----GLARGYHRRPGLTAERFlpd 873
Cdd:cd05970    334 GQTETTLTIATFP-WMEPKPgSMGKPAPGYEIDLIDREGRSCEAGEEGEIVIRTSkgkpvGLFGGYYKDAEKTAEVW--- 409

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  874 pfaADGsrLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQPG-VAGPTLVAYLVPT 952
Cdd:cd05970    410 ---HDG--YYHTGDAAWMDEDGYLWFVGRTDDLIKSSGYRIGPFEVESALIQHPAVLECAVTGVPDpIRGQVVKATIVLA 484

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2183974163  953 EaalvDAESArqQELRSALKNSLLAVLPDYMVPAHMLLLENLPLTPNGKINRKAL 1007
Cdd:cd05970    485 K----GYEPS--EELKKELQDHVKKVTAPYKYPRIVEFVDELPKTISGKIRRVEI 533

A_NRPS_VisG_like

cd17651

similar to adenylation domain of virginiamycin S synthetase; This family of the adenylation (A) ...

3091-3183

3.06e-36

Pssm-ID: 341306 [Multi-domain] Cd Length: 491 Bit Score: 145.95 E-value: 3.06e-36

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3091 FEEQVERTPTAPALAFGEERLDYAELNRRANRLAHALIERGIGADRLVGVAMERSIEMVVALMAILKAGGAYVPVDPEYP 3170
Cdd:cd17651      1 FERQAARTPDAPALVAEGRRLTYAELDRRANRLAHRLRARGVGPGDLVALCARRSAELVVALLAILKAGAAYVPLDPAYP 80

                           90
                   ....*....|...
gi 2183974163 3171 EERQAYMLEDSGV 3183
Cdd:cd17651     81 AERLAFMLADAGP 93

A_NRPS_ApnA-like

cd17644

similar to adenylation domain of anabaenopeptin synthetase (ApnA); This family of the ...

3087-3183

3.31e-36

Pssm-ID: 341299 [Multi-domain] Cd Length: 465 Bit Score: 145.27 E-value: 3.31e-36

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3087 VHRLFEEQVERTPTAPALAFGEERLDYAELNRRANRLAHALIERGIGADRLVGVAMERSIEMVVALMAILKAGGAYVPVD 3166
Cdd:cd17644      2 IHQLFEEQVERTPDAVAVVFEDQQLTYEELNTKANQLAHYLQSLGVKSESLVGICVERSLEMIIGLLAILKAGGAYVPLD 81

                           90
                   ....*....|....*..
gi 2183974163 3167 PEYPEERQAYMLEDSGV 3183
Cdd:cd17644     82 PNYPQERLTYILEDAQI 98

PRK07787

acyl-CoA synthetase; Validated

514-1007

7.75e-36

acyl-CoA synthetase; Validated

Pssm-ID: 236096 [Multi-domain] Cd Length: 471 Bit Score: 144.36 E-value: 7.75e-36

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  514 RLFEAQAGLTPD-APALLFGEERLSYAELNALANRLAWRLREEGvgsdvLVGIALERGVPMVVALLAVLKAGGAYVPLDP 592
Cdd:PRK07787     3 SLNPAAVAAAADiADAVRIGGRVLSRSDLAGAATAVAERVAGAR-----RVAVLATPTLATVLAVVGALIAGVPVVPVPP 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  593 QYPADRLQYMIDDSGLRLLLSqqsvlARLPQSDGLQSLLLDDLERLVHGYPaeNPDlpeaPDSLCYAIYTSGSTGQPKGV 672
Cdd:PRK07787    78 DSGVAERRHILADSGAQAWLG-----PAPDDPAGLPHVPVRLHARSWHRYP--EPD----PDAPALIVYTSGTTGPPKGV 146

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  673 MVRHRALTNFVCSIARQPGMLARDRLLSVTTFsFDIFGLELYV--PLARGASMLLASREqaqDPEALLDLVERQGvTVLQ 750
Cdd:PRK07787   147 VLSRRAIAADLDALAEAWQWTADDVLVHGLPL-FHVHGLVLGVlgPLRIGNRFVHTGRP---TPEAYAQALSEGG-TLYF 221

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  751 ATPATW-RMLCDSERVDLLRGCTLLCGGEA-LAEDLAARMRGLSA-STWNLYGPTETTI-WSARFrlGEEARP-FLGGPL 825
Cdd:PRK07787   222 GVPTVWsRIAADPEAARALRGARLLVSGSAaLPVPVFDRLAALTGhRPVERYGMTETLItLSTRA--DGERRPgWVGLPL 299

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  826 ENTALYILDSEMNPCPPGVA--GELLIGGDGLARGYHRRPGLTAERFLPDPFaadgsrlYRTGDLARYRADGVIEYLGR- 902
Cdd:PRK07787   300 AGVETRLVDEDGGPVPHDGEtvGELQVRGPTLFDGYLNRPDATAAAFTADGW-------FRTGDVAVVDPDGMHRIVGRe 372

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  903 -IDhQVKIRGFRIELGEIETRLLEQDSVREAVVVaqpGVAGPTL----VAYLV----PTEAALVDaESARQqelrsalkn 973
Cdd:PRK07787   373 sTD-LIKSGGYRIGAGEIETALLGHPGVREAAVV---GVPDDDLgqriVAYVVgaddVAADELID-FVAQQ--------- 438

                          490       500       510
                   ....*....|....*....|....*....|....
gi 2183974163  974 slLAVlpdYMVPAHMLLLENLPLTPNGKINRKAL 1007
Cdd:PRK07787   439 --LSV---HKRPREVRFVDALPRNAMGKVLKKQL 467

PRK06188

acyl-CoA synthetase; Validated

524-1007

9.49e-36

acyl-CoA synthetase; Validated

Pssm-ID: 235731 [Multi-domain] Cd Length: 524 Bit Score: 145.13 E-value: 9.49e-36

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  524 PDAPALLFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQYMI 603
Cdd:PRK06188    26 PDRPALVLGDTRLTYGQLADRISRYIQAFEALGLGTGDAVALLSLNRPEVLMAIGAAQLAGLRRTALHPLGSLDDHAYVL 105

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  604 DDSGLRLLLS-----QQSVLARLPQSDGLQSLL-------LDDLERLVHGYPAENPDLPEAPDSLCYAIYTSGSTGQPKG 671
Cdd:PRK06188   106 EDAGISTLIVdpapfVERALALLARVPSLKHVLtlgpvpdGVDLLAAAAKFGPAPLVAAALPPDIAGLAYTGGTTGKPKG 185

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  672 VMVRHRALTNFVCSIARQPGMLARDRLLSVTTFSfDIFGLELYVPLARGASMLLAsreQAQDPEALLDLVERQGVTVLQA 751
Cdd:PRK06188   186 VMGTHRSIATMAQIQLAEWEWPADPRFLMCTPLS-HAGGAFFLPTLLRGGTVIVL---AKFDPAEVLRAIEEQRITATFL 261

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  752 TPATWRMLCDSERV---DLLRGCTLLCGGEALAED-LAARMRGLSASTWNLYGPTET----TIWSARFRLGEEARPFL-- 821
Cdd:PRK06188   262 VPTMIYALLDHPDLrtrDLSSLETVYYGASPMSPVrLAEAIERFGPIFAQYYGQTEApmviTYLRKRDHDPDDPKRLTsc 341

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  822 GGPLENTALYILDSEMNPCPPGVAGELLIGGDGLARGYHRRPGLTAERFlpdpfaADGsrLYRTGDLARYRADGVIEYLG 901
Cdd:PRK06188   342 GRPTPGLRVALLDEDGREVAQGEVGEICVRGPLVMDGYWNRPEETAEAF------RDG--WLHTGDVAREDEDGFYYIVD 413

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  902 RIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQPGVA-GPTLVAYLVPTEAALVDAEsarqqELRSALKNSLLAVlp 980
Cdd:PRK06188   414 RKKDMIVTGGFNVFPREVEDVLAEHPAVAQVAVIGVPDEKwGEAVTAVVVLRPGAAVDAA-----ELQAHVKERKGSV-- 486

                          490       500
                   ....*....|....*....|....*..
gi 2183974163  981 dyMVPAHMLLLENLPLTPNGKINRKAL 1007
Cdd:PRK06188   487 --HAPKQVDFVDSLPLTALGKPDKKAL 511

DCL_NRPS-like

DCL-type Condensation domains of nonribosomal peptide synthetases (NRPSs), such as terminal ...

1114-1535

1.13e-35

Pssm-ID: 380459 [Multi-domain] Cd Length: 419 Bit Score: 142.59 E-value: 1.13e-35

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1114 LSFAQERQWFIWRLDPHSAAYNIPVALRLKGPLRRDALQGALDLLVQRHETLRTTFVEHD-GAPRQVIHPTLPIAIEE-- 1190
Cdd:cd19536      4 LSSLQEGMLFHSLLNPGGSVYLHNYTYTVGRRLNLDLLLEALQVLIDRHDILRTSFIEDGlGQPVQVVHRQAQVPVTEld 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1191 -RRPPVAGEDLKGLVETEAHRPFDLQRGPLLRVLLLPLATDE-CVLVLTLHHIIADGWSMQVLVDELIRVYAALRHDQPP 1268
Cdd:cd19536     84 lTPLEEQLDPLRAYKEETKIRRFDLGRAPLVRAALVRKDERErFLLVISDHHSILDGWSLYLLVKEILAVYNQLLEYKPL 163

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1269 ALAElPIQYADFAAWQRQWMDGGERERqldYWVSRLGGEQpLLELPSdrPRPQQQSHRGRRIGIPLPAELAEALRRLAQA 1348
Cdd:cd19536    164 SLPP-AQPYRDFVAHERASIQQAASER---YWREYLAGAT-LATLPA--LSEAVGGGPEQDSELLVSVPLPVRSRSLAKR 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1349 EQGTLFMLLLASFQALLHRYSGQNDIRVGVPIANRNREET--EGLIGFFVNTQVLRAELDGQlPFRELLRQVRQAVVEAQ 1426
Cdd:cd19536    237 SGIPLSTLLLAAWALVLSRHSGSDDVVFGTVVHGRSEETTgaERLLGLFLNTLPLRVTLSEE-TVEDLLKRAQEQELESL 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1427 GHQDLPfeqLVDAlqpERSLSHAPLFQVMYNHqRDDHRGSRFASLGELEVEDLawDVQTAQFDLTLDTYESSNGLLAELT 1506
Cdd:cd19536    316 SHEQVP---LADI---QRCSEGEPLFDSIVNF-RHFDLDFGLPEWGSDEGMRR--GLLFSEFKSNYDVNLSVLPKQDRLE 386

                          410       420       430
                   ....*....|....*....|....*....|...
gi 2183974163 1507 ----YATDLFDASSAERIAGHWLNLLRSIVARP 1535
Cdd:cd19536    387 lklaYNSQVLDEEQAQRLAAYYKSAIAELATAP 419

CHC_CoA_lg

cd05903

Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); ...

1593-2066

1.29e-35

Pssm-ID: 341229 [Multi-domain] Cd Length: 437 Bit Score: 142.90 E-value: 1.29e-35

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1593 ALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGYMIEDSGIRLLLTQ 1672
Cdd:cd05903      1 RLTYSELDTRADRLAAGLAALGVGPGDVVAFQLPNWWEFAVLYLACLRIGAVTNPILPFFREHELAFILRRAKAKVFVVP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1673 RAARERLPLGEGlpcllldaehewagypesdpqsavgvDNLAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRHWFGFSAD 1752
Cdd:cd05903     81 ERFRQFDPAAMP--------------------------DAVALLLFTSGTTGEPKGVMHSHNTLSASIRQYAERLGLGPG 134

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1753 D----AWSLFHSYAFdfsVWEIFGALLHGGRLVIvpyETSRSPEDFLRLLCRERVTVLNQTPSAFKQLMQVACAGQEVPP 1828
Cdd:cd05903    135 DvflvASPMAHQTGF---VYGFTLPLLLGAPVVL---QDIWDPDKALALMREHGVTFMMGATPFLTDLLNAVEEAGEPLS 208

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1829 lALRHVVFGGEALEVQALRPWFERFGdraPRLVNMYGITETTVHVTYRPLslaDLDGGAASPIGEPIPDLSWYLLDAGLN 1908
Cdd:cd05903    209 -RLRTFVCGGATVPRSLARRAAELLG---AKVCSAYGSTECPGAVTSITP---APEDRRLYTDGRPLPGVEIKVVDDTGA 281

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1909 PVPRGCIGELYVGGAGLARGYLNRPELSctrFVADPfsttgGRLYRTGDLARYRCDGVVEYVGRiDHQVKIR-GFRIELG 1987
Cdd:cd05903    282 TLAPGVEGELLSRGPSVFLGYLDRPDLT---ADAAP-----EGWFRTGDLARLDEDGYLRITGR-SKDIIIRgGENIPVL 352

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1988 EIEARLLAQPGVAEAVV--LPHEGPGaTQLVGYVVTQAAPS-DPAALRDTLrqaLKASLPEHMVPAHLLFLERLPLTANG 2064
Cdd:cd05903    353 EVEDLLLGHPGVIEAAVvaLPDERLG-ERACAVVVTKSGALlTFDELVAYL---DRQGVAKQYWPERLVHVDDLPRTPSG 428


                   ..
gi 2183974163 2065 KL 2066
Cdd:cd05903    429 KV 430

CT_NRPS-like

Terminal Condensation (CT)-like domains of nonribosomal peptide synthetases (NRPSs); Unlike ...

1134-1535

1.56e-35

Pssm-ID: 380464 [Multi-domain] Cd Length: 401 Bit Score: 141.67 E-value: 1.56e-35

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1134 YNIPVALRLKGPLRRDALQGALDLLVQRHETLRTTFVEHDGAPR--QVIHPTLPIAIEE-----------RRPPVAGEDL 1200
Cdd:cd19542     22 YFNHFVFDLDSSVDVERLRNAWRQLVQRHDILRTVFVESSAEGTflQVVLKSLDPPIEEvetdedsldalTRDLLDDPTL 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1201 KGlveTEAHRpFDLQRGpllrvlllplATDECVLVLTLHHIIADGWSMQVLVDELIRVYaalrHDQPPALAElpiQYADF 1280
Cdd:cd19542    102 FG---QPPHR-LTLLET----------SSGEVYLVLRISHALYDGVSLPIILRDLAAAY----NGQLLPPAP---PFSDY 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1281 AAWQRQwmdgGERERQLDYWVSRLGGEQPLLELPSDRPRPQQQShrgrrigIPLPAELAEALRRLAQAEQGTLFMLLLAS 1360
Cdd:cd19542    161 ISYLQS----QSQEESLQYWRKYLQGASPCAFPSLSPKRPAERS-------LSSTRRSLAKLEAFCASLGVTLASLFQAA 229

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1361 FQALLHRYSGQNDIRVGVPIANRN--REETEGLIGFFVNTQVLRAELDGQLPFRELLRQVRQAVVEAQGHQDLPFEQLVD 1438
Cdd:cd19542    230 WALVLARYTGSRDVVFGYVVSGRDlpVPGIDDIVGPCINTLPVRVKLDPDWTVLDLLRQLQQQYLRSLPHQHLSLREIQR 309

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1439 ALqpeRSLSHAPLFQVMYNHQRDDHRGSrFASLGELEVEDLAWDVQTaQFDLTLDTYESSNGLLAELTYATDLFDASSAE 1518
Cdd:cd19542    310 AL---GLWPSGTLFNTLVSYQNFEASPE-SELSGSSVFELSAAEDPT-EYPVAVEVEPSGDSLKVSLAYSTSVLSEEQAE 384

                          410
                   ....*....|....*..
gi 2183974163 1519 RIAGHWLNLLRSIVARP 1535
Cdd:cd19542    385 ELLEQFDDILEALLANP 401

PRK07514

malonyl-CoA synthase; Validated

514-1007

1.92e-35

malonyl-CoA synthase; Validated

Pssm-ID: 181011 [Multi-domain] Cd Length: 504 Bit Score: 143.86 E-value: 1.92e-35

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  514 RLFEAQAGltPDAPALLFGE-ERLSYAELNALANRLAWRLREEGV--GSDVLVGIalERGVPMVVALLAVLKAGGAYVPL 590
Cdd:PRK07514     8 ALRAAFAD--RDAPFIETPDgLRYTYGDLDAASARLANLLVALGVkpGDRVAVQV--EKSPEALALYLATLRAGAVFLPL 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  591 DPQYPADRLQYMIDDSGLRLLL---SQQSVLARLPQSDGLQSLL-LDD-----LERLVHGYPAENPDLPEAPDSLCYAIY 661
Cdd:PRK07514    84 NTAYTLAELDYFIGDAEPALVVcdpANFAWLSKIAAAAGAPHVEtLDAdgtgsLLEAAAAAPDDFETVPRGADDLAAILY 163

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  662 TSGSTGQPKGVMVRHRALTNFVCSIARQPGMLARDRLLSvttfSFDIF---GL--ELYVPLARGASMLLASReqaQDPEA 736
Cdd:PRK07514   164 TSGTTGRSKGAMLSHGNLLSNALTLVDYWRFTPDDVLIH----ALPIFhthGLfvATNVALLAGASMIFLPK---FDPDA 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  737 LLDLVERqgVTVLQATPATW-RMLCDservdllrgctllcggEALAEDLAARMR----G---LSASTWN----------- 797
Cdd:PRK07514   237 VLALMPR--ATVMMGVPTFYtRLLQE----------------PRLTREAAAHMRlfisGsapLLAETHRefqertghail 298

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  798 -LYGPTETTIWSARFRLGEEARPFLGGPLENTALYILDSEMN-PCPPGVAGELLIGGDGLARGYHRRPGLTAERFLPDPF 875
Cdd:PRK07514   299 eRYGMTETNMNTSNPYDGERRAGTVGFPLPGVSLRVTDPETGaELPPGEIGMIEVKGPNVFKGYWRMPEKTAEEFRADGF 378

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  876 aadgsrlYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVaqpGVA----GPTLVAYLVP 951
Cdd:PRK07514   379 -------FITGDLGKIDERGYVHIVGRGKDLIISGGYNVYPKEVEGEIDELPGVVESAVI---GVPhpdfGEGVTAVVVP 448

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2183974163  952 TEAALVDaESARQQELRSALKNsllavlpdYMVPAHMLLLENLPLTPNGKINRKAL 1007
Cdd:PRK07514   449 KPGAALD-EAAILAALKGRLAR--------FKQPKRVFFVDELPRNTMGKVQKNLL 495

OSB_CoA_lg

cd05912

O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA ...

1596-2071

2.12e-35

O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); O-succinylbenzoic acid-CoA synthase catalyzes the coenzyme A (CoA)- and ATP-dependent conversion of o-succinylbenzoic acid to o-succinylbenzoyl-CoA. The reaction is the fourth step of the biosynthesis pathway of menaquinone (vitamin K2). In certain bacteria, menaquinone is used during fumarate reduction in anaerobic respiration. In cyanobacteria, the product of the menaquinone pathway is phylloquinone (2-methyl-3-phytyl-1,4-naphthoquinone), a molecule used exclusively as an electron transfer cofactor in Photosystem 1. In green sulfur bacteria and heliobacteria, menaquinones are used as loosely bound secondary electron acceptors in the photosynthetic reaction center.

Pssm-ID: 341238 [Multi-domain] Cd Length: 411 Bit Score: 141.72 E-value: 2.12e-35

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1596 YGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGYMIEDSGirllltqraa 1675
Cdd:cd05912      4 FAELFEEVSRLAEHLAALGVRKGDRVALLSKNSIEMILLIHALWLLGAEAVLLNTRLTPNELAFQLKDSD---------- 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1676 rerlplgeglpcllldaehewagypesdpqsaVGVDNLAYVIYTSGSTGKPKGTLLPHGNvlrlfdatrHWF-------- 1747
Cdd:cd05912     74 --------------------------------VKLDDIATIMYTSGTTGKPKGVQQTFGN---------HWWsaigsaln 112

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1748 -GFSADDAW----SLFHSYAfdFSVweIFGALLHGGRLVIVPyetSRSPEDFLRLLCRERVTVLNQTPSAFKQLMQVacA 1822
Cdd:cd05912    113 lGLTEDDNWlcalPLFHISG--LSI--LMRSVIYGMTVYLVD---KFDAEQVLHLINSGKVTIISVVPTMLQRLLEI--L 183

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1823 GQEVPPlALRHVVFGGEalevQALRPWFERFGDRAPRLVNMYGITETTVH-VTYRPLSLADLDGGAaspiGEPIPDLSWY 1901
Cdd:cd05912    184 GEGYPN-NLRCILLGGG----PAPKPLLEQCKEKGIPVYQSYGMTETCSQiVTLSPEDALNKIGSA----GKPLFPVELK 254

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1902 LLDAGLNPvprGCIGELYVGGAGLARGYLNRPELSCTRFVADPFsttggrlyRTGDLARYRCDGVVEYVGRIDHQVKIRG 1981
Cdd:cd05912    255 IEDDGQPP---YEVGEILLKGPNVTKGYLNRPDATEESFENGWF--------KTGDIGYLDEEGFLYVLDRRSDLIISGG 323

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1982 FRIELGEIEARLLAQPGVAEAVVLPHEGPGATQL-VGYVVTQAAPSdpaalRDTLRQALKASLPEHMVPAHLLFLERLPL 2060
Cdd:cd05912    324 ENIYPAEIEEVLLSHPAIKEAGVVGIPDDKWGQVpVAFVVSERPIS-----EEELIAYCSEKLAKYKVPKKIYFVDELPR 398

                          490
                   ....*....|.
gi 2183974163 2061 TANGKLDRRAL 2071
Cdd:cd05912    399 TASGKLLRHEL 409

PRK06087

medium-chain fatty-acid--CoA ligase;

1576-2086

2.39e-35

medium-chain fatty-acid--CoA ligase;

Pssm-ID: 180393 [Multi-domain] Cd Length: 547 Bit Score: 144.51 E-value: 2.39e-35

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1576 RQAAERPRATAVVYGERA-LDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPS 1654
Cdd:PRK06087    31 QTARAMPDKIAVVDNHGAsYTYSALDHAASRLANWLLAKGIEPGDRVAFQLPGWCEFTIIYLACLKVGAVSVPLLPSWRE 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1655 DRLGYMIEDSGIRLLLTQRAARERLPLGEGLPC----------LLLDAE----------HEWAGY-PESDPQSAVGvDNL 1713
Cdd:PRK06087   111 AELVWVLNKCQAKMFFAPTLFKQTRPVDLILPLqnqlpqlqqiVGVDKLapatsslslsQIIADYePLTTAITTHG-DEL 189

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1714 AYVIYTSGSTGKPKGTLLPHGNVL---RLFDATrhwFGFSADD----AWSLFHSYAFDFSVWEIFgalLHGGRLVIvpyE 1786
Cdd:PRK06087   190 AAVLFTSGTEGLPKGVMLTHNNILaseRAYCAR---LNLTWQDvfmmPAPLGHATGFLHGVTAPF---LIGARSVL---L 260

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1787 TSRSPEDFLRLLCRERVT-VLNQTPSAFKQLMQVACAGQEVPplALRHVVFGGEALEVQALRPWFErfgdRAPRLVNMYG 1865
Cdd:PRK06087   261 DIFTPDACLALLEQQRCTcMLGATPFIYDLLNLLEKQPADLS--ALRFFLCGGTTIPKKVARECQQ----RGIKLLSVYG 334

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1866 ITETTVHVTYRPLSLADLDGGAAspiGEPIPDLSWYLLDAGLNPVPRGCIGELYVGGAGLARGYLNRPELSCTRFVADPF 1945
Cdd:PRK06087   335 STESSPHAVVNLDDPLSRFMHTD---GYAAAGVEIKVVDEARKTLPPGCEGEEASRGPNVFMGYLDEPELTARALDEEGW 411

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1946 sttggrlYRTGDLARYRCDGVVEYVGRiDHQVKIRGFR-IELGEIEARLLAQPGVAEAVV--LPHEGPGaTQLVGYVVTQ 2022
Cdd:PRK06087   412 -------YYSGDLCRMDEAGYIKITGR-KKDIIVRGGEnISSREVEDILLQHPKIHDACVvaMPDERLG-ERSCAYVVLK 482

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2183974163 2023 AAPSDPaALRDTLRQALKASLPEHMVPAHLLFLERLPLTANGKLDRRALPAPDASRLQRDYTAP 2086
Cdd:PRK06087   483 APHHSL-TLEEVVAFFSRKRVAKYKYPEHIVVIDKLPRTASGKIQKFLLRKDIMRRLTQDVCEE 545

ttLC_FACS_AlkK_like

cd12119

Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; This family includes ...

532-1007

3.41e-35

Pssm-ID: 341284 [Multi-domain] Cd Length: 518 Bit Score: 143.54 E-value: 3.41e-35

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  532 GEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQYMIDDSGLRLL 611
Cdd:cd12119     22 EVHRYTYAEVAERARRLANALRRLGVKPGDRVATLAWNTHRHLELYYAVPGMGAVLHTINPRLFPEQIAYIINHAEDRVV 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  612 LSQQS-------VLARLPQ-------SDGLQSLLLDDL-----ERLVHGYPAE--NPDLPE-APDSLCYaiyTSGSTGQP 669
Cdd:cd12119    102 FVDRDflplleaIAPRLPTvehvvvmTDDAAMPEPAGVgvlayEELLAAESPEydWPDFDEnTAAAICY---TSGTTGNP 178

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  670 KGVMVRHRALTNFVCSIARQPGML--ARDRLLSVT-TFSFDIFGLElYVPLARGASMLLASReqAQDPEALLDLVERQGV 746
Cdd:cd12119    179 KGVVYSHRSLVLHAMAALLTDGLGlsESDVVLPVVpMFHVNAWGLP-YAAAMVGAKLVLPGP--YLDPASLAELIEREGV 255

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  747 TVLQATPATWRML---CDSERVDLLRGCTLLCGGEALAEDLAARMRGLSASTWNLYGPTET----TI----WSARFRLGE 815
Cdd:cd12119    256 TFAAGVPTVWQGLldhLEANGRDLSSLRRVVIGGSAVPRSLIEAFEERGVRVIHAWGMTETsplgTVarppSEHSNLSED 335

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  816 EARPFL---GGPLENTALYILDSEMNPCP--PGVAGELLIGGDGLARGYHRRPGLTAERFlpdpfaADGsrLYRTGDLAR 890
Cdd:cd12119    336 EQLALRakqGRPVPGVELRIVDDDGRELPwdGKAVGELQVRGPWVTKSYYKNDEESEALT------EDG--WLRTGDVAT 407

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  891 YRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQPG---VAGPtlVAYLVPTEAALVDAEsarqqel 967
Cdd:cd12119    408 IDEDGYLTITDRSKDVIKSGGEWISSVELENAIMAHPAVAEAAVIGVPHpkwGERP--LAVVVLKEGATVTAE------- 478

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|
gi 2183974163  968 rsALKNSLLAVLPDYMVPAHMLLLENLPLTPNGKINRKAL 1007
Cdd:cd12119    479 --ELLEFLADKVAKWWLPDDVVFVDEIPKTSTGKIDKKAL 516

4CL

cd05904

4-Coumarate-CoA Ligase (4CL); 4-Coumarate:coenzyme A ligase is a key enzyme in the ...

1578-2022

3.55e-35

4-Coumarate-CoA Ligase (4CL); 4-Coumarate:coenzyme A ligase is a key enzyme in the phenylpropanoid metabolic pathway for monolignol and flavonoid biosynthesis. It catalyzes the synthesis of hydroxycinnamate-CoA thioesters in a two-step reaction, involving the formation of hydroxycinnamate-AMP anhydride and the nucleophilic substitution of AMP by CoA. The phenylpropanoid pathway is one of the most important secondary metabolism pathways in plants and hydroxycinnamate-CoA thioesters are the precursors of lignin and other important phenylpropanoids.

Pssm-ID: 341230 [Multi-domain] Cd Length: 505 Bit Score: 143.14 E-value: 3.55e-35

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1578 AAERPRATAVVYGE--RALDYGELNLRANRLAHRLIELGVGP-DVlVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPS 1654
Cdd:cd05904     15 ASAHPSRPALIDAAtgRALTYAELERRVRRLAAGLAKRGGRKgDV-VLLLSPNSIEFPVAFLAVLSLGAVVTTANPLSTP 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1655 DRLGYMIEDSGIRLLLTQRAARERLPlGEGLPCLLLDAEHEWAGYPESD---------PQSAVGVDNLAYVIYTSGSTGK 1725
Cdd:cd05904     94 AEIAKQVKDSGAKLAFTTAELAEKLA-SLALPVVLLDSAEFDSLSFSDLlfeadeaepPVVVIKQDDVAALLYSSGTTGR 172

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1726 PKGTLLPHGN-------VLRLFDATRHwfgfsADDAW----SLFHSYAFDFsvweIFGALLH-GGRLVIVP-YETsrspE 1792
Cdd:cd05904    173 SKGVMLTHRNliamvaqFVAGEGSNSD-----SEDVFlcvlPMFHIYGLSS----FALGLLRlGATVVVMPrFDL----E 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1793 DFLRLLCRERVTVLNQTPSAFKQLMQVACAGQEvPPLALRHVVFGGEAL--EVQalrpwfERFGDRAP--RLVNMYGITE 1868
Cdd:cd05904    240 ELLAAIERYKVTHLPVVPPIVLALVKSPIVDKY-DLSSLRQIMSGAAPLgkELI------EAFRAKFPnvDLGQGYGMTE 312

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1869 TT--VHVTYRPLSLAdldgGAASPIGEPIPDLSWYLLD-AGLNPVPRGCIGELYVGGAGLARGYLNRPELSCTRFVADpf 1945
Cdd:cd05904    313 STgvVAMCFAPEKDR----AKYGSVGRLVPNVEAKIVDpETGESLPPNQTGELWIRGPSIMKGYLNNPEATAATIDKE-- 386

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2183974163 1946 sttgGRLyRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVVLPHEGPGATQL-VGYVVTQ 2022
Cdd:cd05904    387 ----GWL-HTGDLCYIDEDGYLFIVDRLKELIKYKGFQVAPAELEALLLSHPEILDAAVIPYPDEEAGEVpMAFVVRK 459

PRK07470

acyl-CoA synthetase; Validated

1576-2093

3.64e-35

acyl-CoA synthetase; Validated

Pssm-ID: 180988 [Multi-domain] Cd Length: 528 Bit Score: 143.64 E-value: 3.64e-35

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1576 RQAAER-PRATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPS 1654
Cdd:PRK07470    14 RQAARRfPDRIALVWGDRSWTWREIDARVDALAAALAARGVRKGDRILVHSRNCNQMFESMFAAFRLGAVWVPTNFRQTP 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1655 DRLGYMIEDSGIRLLLTQ-------RAARE-----RLPLGEGLPCLLLDAEHEWAGYPESDPQSA-VGVDNLAYVIYTSG 1721
Cdd:PRK07470    94 DEVAYLAEASGARAMICHadfpehaAAVRAaspdlTHVVAIGGARAGLDYEALVARHLGARVANAaVDHDDPCWFFFTSG 173

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1722 STGKPKGTLLPHGNVLrlFDATRHWF----GFSADDA----WSLFHsyafdfsvweifGALLH-------GGRLVIVPYE 1786
Cdd:PRK07470   174 TTGRPKAAVLTHGQMA--FVITNHLAdlmpGTTEQDAslvvAPLSH------------GAGIHqlcqvarGAATVLLPSE 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1787 tSRSPEDFLRLLCRERVTVLNQTPSAFKQLMqvacagqEVPPLA------LRHVVFGG----EALEVQALRpwfeRFGdr 1856
Cdd:PRK07470   240 -RFDPAEVWALVERHRVTNLFTVPTILKMLV-------EHPAVDrydhssLRYVIYAGapmyRADQKRALA----KLG-- 305

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1857 aPRLVNMYGITETTVHVTYRPLSLADLDGGAASPIGE---PIPDLSWYLLDAGLNPVPRGCIGELYVGGAGLARGYLNRP 1933
Cdd:PRK07470   306 -KVLVQYFGLGEVTGNITVLPPALHDAEDGPDARIGTcgfERTGMEVQIQDDEGRELPPGETGEICVIGPAVFAGYYNNP 384

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1934 ELSCTRFVADPFsttggrlyRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVVL--PHEGPG 2011
Cdd:PRK07470   385 EANAKAFRDGWF--------RTGDLGHLDARGFLYITGRASDMYISGGSNVYPREIEEKLLTHPAVSEVAVLgvPDPVWG 456

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2012 AtqlVGYVVTQAapSDPAAL-RDTLRQALKASLPEHMVPAHLLFLERLPLTANGKLDRRALpapdasrlqrdytapRSEL 2090
Cdd:PRK07470   457 E---VGVAVCVA--RDGAPVdEAELLAWLDGKVARYKLPKRFFFWDALPKSGYGKITKKMV---------------REEL 516


                   ...
gi 2183974163 2091 EQR 2093
Cdd:PRK07470   517 EER 519

AACS_like

cd05968

Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; This ...

1553-2073

4.45e-35

Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; This uncharacterized acyl-CoA synthetase family (EC 6.2.1.16, or acetoacetate#CoA ligase or acetoacetate:CoA ligase (AMP-forming)) is highly homologous to acetoacetyl-CoA synthetase. However, the proteins in this family exist in only bacteria and archaea. AACS is a cytosolic ligase that specifically activates acetoacetate to its coenzyme A ester by a two-step reaction. Acetoacetate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is the first step of the mevalonate pathway of isoprenoid biosynthesis via isopentenyl diphosphate. Isoprenoids are a large class of compounds found in all living organisms.

Pssm-ID: 341272 [Multi-domain] Cd Length: 610 Bit Score: 144.56 E-value: 4.45e-35

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1553 DLLQWNPGPQDFTPASC--LHRLIERQAAERPRATAVVY-GE----RALDYGELNLRANRLAHRLIELGVGPDVLVGLAA 1625
Cdd:cd05968     44 DLSGGKPWAAWFVGGRMniVEQLLDKWLADTRTRPALRWeGEdgtsRTLTYGELLYEVKRLANGLRALGVGKGDRVGIYL 123

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1626 ERSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGYMIEDSGIRLLLTQ----RAARERLPLGE------------------ 1683
Cdd:cd05968    124 PMIPEIVPAFLAVARIGGIVVPIFSGFGKEAAATRLQDAEAKALITAdgftRRGREVNLKEEadkacaqcptvekvvvvr 203

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1684 --GLPCLLLDAEHEWagYPE----SDPQSA-VGVDNLAYVIYTSGSTGKPKGTLLPHGN--VLRLFDATrHWFGFSADDA 1754
Cdd:cd05968    204 hlGNDFTPAKGRDLS--YDEeketAGDGAErTESEDPLMIIYTSGTTGKPKGTVHVHAGfpLKAAQDMY-FQFDLKPGDL 280

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1755 WSLFHSYAFDFSVWEIFGALLHGGRLVIvpYETS---RSPEDFLRLLCRERVTVLNQTPSAFKQLMQVACAGQEVPPL-A 1830
Cdd:cd05968    281 LTWFTDLGWMMGPWLIFGGLILGATMVL--YDGApdhPKADRLWRMVEDHEITHLGLSPTLIRALKPRGDAPVNAHDLsS 358

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1831 LRhvVFG--GEALEVQALRPWFERFGDRAPRLVNMYGITETT----VHVTYRPLSLADLDGgaaspigePIPDLSWYLLD 1904
Cdd:cd05968    359 LR--VLGstGEPWNPEPWNWLFETVGKGRNPIINYSGGTEISggilGNVLIKPIKPSSFNG--------PVPGMKADVLD 428

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1905 AGLNPVpRGCIGELYVGGA--GLARGYLNRPElsctRFVADPFSTTGGrLYRTGDLARYRCDGVVEYVGRIDHQVKIRGF 1982
Cdd:cd05968    429 ESGKPA-RPEVGELVLLAPwpGMTRGFWRDED----RYLETYWSRFDN-VWVHGDFAYYDEEGYFYILGRSDDTINVAGK 502

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1983 RIELGEIEARLLAQPGVAE--AVVLPHEGPGaTQLVGYVVTQAAPSDPAALRDTLRQALKASLPEHMVPAHLLFLERLPL 2060
Cdd:cd05968    503 RVGPAEIESVLNAHPAVLEsaAIGVPHPVKG-EAIVCFVVLKPGVTPTEALAEELMERVADELGKPLSPERILFVKDLPK 581

                          570
                   ....*....|...
gi 2183974163 2061 TANGKLDRRALPA 2073
Cdd:cd05968    582 TRNAKVMRRVIRA 594

A_NRPS_CmdD_like

cd17652

similar to adenylation domain of chondramide synthase cmdD; This family of the adenylation (A) ...

3099-3182

5.50e-35

Pssm-ID: 341307 [Multi-domain] Cd Length: 436 Bit Score: 141.24 E-value: 5.50e-35

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3099 PTAPALAFGEERLDYAELNRRANRLAHALIERGIGADRLVGVAMERSIEMVVALMAILKAGGAYVPVDPEYPEERQAYML 3178
Cdd:cd17652      1 PDAPAVVFGDETLTYAELNARANRLARLLAARGVGPERLVALALPRSAELVVAILAVLKAGAAYLPLDPAYPAERIAYML 80


                   ....
gi 2183974163 3179 EDSG 3182
Cdd:cd17652     81 ADAR 84

A_NRPS_Sfm_like

cd12115

The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene ...

3087-3183

5.64e-35

Pssm-ID: 341280 [Multi-domain] Cd Length: 447 Bit Score: 141.30 E-value: 5.64e-35

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3087 VHRLFEEQVERTPTAPALAFGEERLDYAELNRRANRLAHALIERGIGADRLVGVAMERSIEMVVALMAILKAGGAYVPVD 3166
Cdd:cd12115      1 LHDLVEAQAARTPDAIALVCGDESLTYAELNRRANRLAARLRAAGVGPESRVGVCLERTPDLVVALLAVLKAGAAYVPLD 80

                           90
                   ....*....|....*..
gi 2183974163 3167 PEYPEERQAYMLEDSGV 3183
Cdd:cd12115     81 PAYPPERLRFILEDAQA 97

C_NRPS-like

Condensation family domain with an atypical active site motif; Condensation (C) domains of ...

49-476

6.76e-35

Pssm-ID: 380460 [Multi-domain] Cd Length: 395 Bit Score: 139.63 E-value: 6.76e-35

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163   49 PLSYAqERQWFLW-QMDPQSAAYNIPSALRLRGELDVEALSASLGAIVERHQSLRTVFVEDeqlDGF----------RQQ 117
Cdd:cd19537      3 ALSPI-EREWWHKyQLSTGTSSFNVSFACRLSGDVDRDRLASAWNTVLARHRILRSRYVPR---DGGlrrsysssppRVQ 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  118 VLASVDVPVPVTLAGDDDAQAQIRAFVESETqqpfdlrngpllrarllrlaaddhvLTLTIHHVAADGWSMRVLVEELIA 197
Cdd:cd19537     79 RVDTLDVWKEINRPFDLEREDPIRVFISPDT-------------------------LLVVMSHIICDLTTLQLLLREVSA 133

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  198 LYGARrqgieaTLPDLPIQYADYAIWQRHwleagERERQLEYWMARLGGGQsVLELPTdrqRPALPSYRGARHELQLPQA 277
Cdd:cd19537    134 AYNGK------LLPPVRREYLDSTAWSRP-----ASPEDLDFWSEYLSGLP-LLNLPR---RTSSKSYRGTSRVFQLPGS 198

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  278 LGRQLQALAQREGTTLFMLLLASFQALLHRYSGQDEIRVGVPVANRNRVETERLIGFFVntQVL----RADLDAQMPFLD 353
Cdd:cd19537    199 LYRSLLQFSTSSGITLHQLALAAVALALQDLSDRTDIVLGAPYLNRTSEEDMETVGLFL--EPLpiriRFPSSSDASAAD 276

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  354 LLQQTRVAALGAQSHQdLPFEQLVEALQ-PERSLSHsPLFQAM--YNHqnlgsAGRQSLAAQLPGLSVEdLSWgAHSAQF 430
Cdd:cd19537    277 FLRAVRRSSQAALAHA-IPWHQLLEHLGlPPDSPNH-PLFDVMvtFHD-----DRGVSLALPIPGVEPL-YTW-AEGAKF 347

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*..
gi 2183974163  431 DLTLD-TYESEQGVHAEFTYATDLFEAATVERLARHWRNLLEAVVAE 476
Cdd:cd19537    348 PLMFEfTALSDDSLLLRLEYDTDCFSEEEIDRIESLILAALELLVEG 394

PRK08314

long-chain-fatty-acid--CoA ligase; Validated

1561-2081

7.32e-35

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 236235 [Multi-domain] Cd Length: 546 Bit Score: 142.79 E-value: 7.32e-35

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1561 PQDFT-PASCLHRLIERQAAERPRATAVVYGERALDYGELNLRANRLAHRLI-ELGVGPDVLVGLAAERSLEMIVGLLAI 1638
Cdd:PRK08314     2 PKSLTlPETSLFHNLEVSARRYPDKTAIVFYGRAISYRELLEEAERLAGYLQqECGVRKGDRVLLYMQNSPQFVIAYYAI 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1639 LKAGGAYVPLDPRYPSDRLGYMIEDSGIRLLLT-QRAARERLPL--GEGLPCLL-------------------LDAEHEW 1696
Cdd:PRK08314    82 LRANAVVVPVNPMNREEELAHYVTDSGARVAIVgSELAPKVAPAvgNLRLRHVIvaqysdylpaepeiavpawLRAEPPL 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1697 AGYPESD--------------PQSAVGVDNLAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRHWFGFSADD----AWSLF 1758
Cdd:PRK08314   162 QALAPGGvvawkealaaglapPPHTAGPDDLAVLPYTSGTTGVPKGCMHTHRTVMANAVGSVLWSNSTPESvvlaVLPLF 241

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1759 HSYAFDFSVweiFGALLHGGRLVIVPY---ETSRspedflRLLCRERVTVLNQTPSafkqlMQVACAGQevPPLA----- 1830
Cdd:PRK08314   242 HVTGMVHSM---NAPIYAGATVVLMPRwdrEAAA------RLIERYRVTHWTNIPT-----MVVDFLAS--PGLAerdls 305

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1831 -LRHVVFGGEALEVQALRPWFERFGdraPRLVNMYGITETTVHVTYRPLSLADLDGgaaspIGEPIPDLSWYLLD-AGLN 1908
Cdd:PRK08314   306 sLRYIGGGGAAMPEAVAERLKELTG---LDYVEGYGLTETMAQTHSNPPDRPKLQC-----LGIPTFGVDARVIDpETLE 377

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1909 PVPRGCIGELYVGGAGLARGYLNRPELSctrfvADPFSTTGG-RLYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELG 1987
Cdd:PRK08314   378 ELPPGEVGEIVVHGPQVFKGYWNRPEAT-----AEAFIEIDGkRFFRTGDLGRMDEEGYFFITDRLKRMINASGFKVWPA 452

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1988 EIEARLLAQPGVAEAVVL----PHEGPGATQLVgyVVTQAAPSDPAAlrdtlrQALKASLPEHM----VPAHLLFLERLP 2059
Cdd:PRK08314   453 EVENLLYKHPAIQEACVIatpdPRRGETVKAVV--VLRPEARGKTTE------EEIIAWAREHMaaykYPRIVEFVDSLP 524

                          570       580
                   ....*....|....*....|..
gi 2183974163 2060 LTANGKLDRRALPAPDASRLQR 2081
Cdd:PRK08314   525 KSGSGKILWRQLQEQEKARAAK 546

FAAL

cd05931

Fatty acyl-AMP ligase (FAAL); FAAL belongs to the class I adenylate forming enzyme family and ...

520-1021

8.52e-35

Pssm-ID: 341254 [Multi-domain] Cd Length: 547 Bit Score: 142.76 E-value: 8.52e-35

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  520 AGLTPDAPALLF------GEERLSYAELNALANRLAWRLREEGVGSDVlVGIALERGVPMVVALLAVLKAGGAYVPL--- 590
Cdd:cd05931      3 AAARPDRPAYTFlddeggREETLTYAELDRRARAIAARLQAVGKPGDR-VLLLAPPGLDFVAAFLGCLYAGAIAVPLppp 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  591 DPQYPADRLQYMIDDSGLRLLLSQQSVLARLPQ------SDGLQSLLLDDLERLVHGYPAENPDLpeAPDSLCYAIYTSG 664
Cdd:cd05931     82 TPGRHAERLAAILADAGPRVVLTTAAALAAVRAfaasrpAAGTPRLLVVDLLPDTSAADWPPPSP--DPDDIAYLQYTSG 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  665 STGQPKGVMVRHRALTNFVCSIARQPGMLARDRLLSVTTFSFDiFGLE--LYVPLARGA-SMLLASREQAQDPEALLDLV 741
Cdd:cd05931    160 STGTPKGVVVTHRNLLANVRQIRRAYGLDPGDVVVSWLPLYHD-MGLIggLLTPLYSGGpSVLMSPAAFLRRPLRWLRLI 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  742 ERQGVTVLQATPATWRmLC-------DSERVDLLRGCTLLCGGE----ALAEDLAARMR--GLSASTwnL---YGPTETT 805
Cdd:cd05931    239 SRYRATISAAPNFAYD-LCvrrvrdeDLEGLDLSSWRVALNGAEpvrpATLRRFAEAFApfGFRPEA--FrpsYGLAEAT 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  806 --------------IWSARFRL----------GEEARPFL--GGPLENTALYILDSEMN-PCPPGVAGELLIGGDGLARG 858
Cdd:cd05931    316 lfvsggppgtgpvvLRVDRDALagravavaadDPAARELVscGRPLPDQEVRIVDPETGrELPDGEVGEIWVRGPSVASG 395

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  859 YHRRPGLTAERFLPDPfAADGSRLYRTGDLArYRADGVIEYLGRIDHQVKIRGFRIELGEIETrlleqdSVREAVVVAQP 938
Cdd:cd05931    396 YWGRPEATAETFGALA-ATDEGGWLRTGDLG-FLHDGELYITGRLKDLIIVRGRNHYPQDIEA------TAEEAHPALRP 467

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  939 GVAgptlVAYLVP---TEAALVDAESARQQ---ELRSALKNSLLAVLPDYMVPAHMLLLEN---LPLTPNGKINRkalpl 1009
Cdd:cd05931    468 GCV----AAFSVPddgEERLVVVAEVERGAdpaDLAAIAAAIRAAVAREHGVAPADVVLVRpgsIPRTSSGKIQR----- 538

                          570
                   ....*....|..
gi 2183974163 1010 pdaSAVRDAHVA 1021
Cdd:cd05931    539 ---RACRAAYLD 547

PRK06164

acyl-CoA synthetase; Validated

1570-2070

1.17e-34

acyl-CoA synthetase; Validated

Pssm-ID: 235722 [Multi-domain] Cd Length: 540 Bit Score: 142.19 E-value: 1.17e-34

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1570 LHRLIERQAAERPRATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLD 1649
Cdd:PRK06164    12 LASLLDAHARARPDAVALIDEDRPLSRAELRALVDRLAAWLAAQGVRRGDRVAVWLPNCIEWVVLFLACARLGATVIAVN 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1650 PRYPSDRLGYMIEDSGIRLLLTQRAAR--------------ERLPL---------GEGLPCLLLDAEHEWAGYPESDPQS 1706
Cdd:PRK06164    92 TRYRSHEVAHILGRGRARWLVVWPGFKgidfaailaavppdALPPLraiavvddaADATPAPAPGARVQLFALPDPAPPA 171

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1707 AVGV-----DNLAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRHWFGFSADDAW--SLFHSYAFDFSVweIFGALLHGGR 1779
Cdd:PRK06164   172 AAGEraadpDAGALLFTTSGTTSGPKLVLHRQATLLRHARAIARAYGYDPGAVLlaALPFCGVFGFST--LLGALAGGAP 249

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1780 LVIVP-YETSRSpedfLRLLCRERVTVLNQTPSAFKQLMQVACAGQEVPplALRHVVFGGEALEVQALRPWFErfgDRAP 1858
Cdd:PRK06164   250 LVCEPvFDAART----ARALRRHRVTHTFGNDEMLRRILDTAGERADFP--SARLFGFASFAPALGELAALAR---ARGV 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1859 RLVNMYGITETTVHVTYRPLSLAD----LDGGA-ASPIGE-PIPDlswyLLDAGLnpVPRGCIGELYVGGAGLARGYLNR 1932
Cdd:PRK06164   321 PLTGLYGSSEVQALVALQPATDPVsvriEGGGRpASPEARvRARD----PQDGAL--LPDGESGEIEIRAPSLMRGYLDN 394

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1933 PELSCTRFVADPFsttggrlYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVVLPHEGPGA 2012
Cdd:PRK06164   395 PDATARALTDDGY-------FRTGDLGYTRGDGQFVYQTRMGDSLRLGGFLVNPAEIEHALEALPGVAAAQVVGATRDGK 467

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2183974163 2013 TQLVGYVVTQA-APSDPAALRDTLRQALKAslpeHMVPAHLLFLERLPLT--ANGKLDRRA 2070
Cdd:PRK06164   468 TVPVAFVIPTDgASPDEAGLMAACREALAG----FKVPARVQVVEAFPVTesANGAKIQKH 524

4CL

cd05904

4-Coumarate-CoA Ligase (4CL); 4-Coumarate:coenzyme A ligase is a key enzyme in the ...

524-950

1.33e-34

Pssm-ID: 341230 [Multi-domain] Cd Length: 505 Bit Score: 141.22 E-value: 1.33e-34

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  524 PDAPALLFGE--ERLSYAELNALANRLAWRLREEGVGS-DVlVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQ 600
Cdd:cd05904     19 PSRPALIDAAtgRALTYAELERRVRRLAAGLAKRGGRKgDV-VLLLSPNSIEFPVAFLAVLSLGAVVTTANPLSTPAEIA 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  601 YMIDDSGLRLLLSQQSVLARLPQSdGLQSLLLDDLERLVHGY-----PAENPDLPEA---PDSLCYAIYTSGSTGQPKGV 672
Cdd:cd05904     98 KQVKDSGAKLAFTTAELAEKLASL-ALPVVLLDSAEFDSLSFsdllfEADEAEPPVVvikQDDVAALLYSSGTTGRSKGV 176

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  673 MVRHRALTNFVCSI-ARQPGMLAR-DRLLSVTTFsFDIFGLELYV--PLARGASMLLASReqaQDPEALLDLVERQGVTV 748
Cdd:cd05904    177 MLTHRNLIAMVAQFvAGEGSNSDSeDVFLCVLPM-FHIYGLSSFAlgLLRLGATVVVMPR---FDLEELLAAIERYKVTH 252

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  749 LQATPATWRMLCDSERV---DLLRGCTLLCGGEALAEDLAARMR----------GlsastwnlYGPTETTIWSARFRLGE 815
Cdd:cd05904    253 LPVVPPIVLALVKSPIVdkyDLSSLRQIMSGAAPLGKELIEAFRakfpnvdlgqG--------YGMTESTGVVAMCFAPE 324

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  816 EARPFLG--GPL-ENTALYILDSEMN-PCPPGVAGELLIGGDGLARGYHRRPGLTAERFLPDPFaadgsrlYRTGDLARY 891
Cdd:cd05904    325 KDRAKYGsvGRLvPNVEAKIVDPETGeSLPPNQTGELWIRGPSIMKGYLNNPEATAATIDKEGW-------LHTGDLCYI 397

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  892 RADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQPG-VAGPTLVAYLV 950
Cdd:cd05904    398 DEDGYLFIVDRLKELIKYKGFQVAPAELEALLLSHPEILDAAVIPYPDeEAGEVPMAFVV 457

A_NRPS_AB3403-like

cd17646

Peptide Synthetase; The adenylation (A) domain of NRPS recognizes a specific amino acid or ...

3088-3183

1.38e-34

Pssm-ID: 341301 [Multi-domain] Cd Length: 488 Bit Score: 140.87 E-value: 1.38e-34

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3088 HRLFEEQVERTPTAPALAFGEERLDYAELNRRANRLAHALIERGIGADRLVGVAMERSIEMVVALMAILKAGGAYVPVDP 3167
Cdd:cd17646      1 HALVAEQAARTPDAPAVVDEGRTLTYRELDERANRLAHLLRARGVGPEDRVAVLLPRSADLVVALLAVLKAGAAYLPLDP 80

                           90
                   ....*....|....*.
gi 2183974163 3168 EYPEERQAYMLEDSGV 3183
Cdd:cd17646     81 GYPADRLAYMLADAGP 96

A_NRPS_PvdJ-like

cd17649

non-ribosomal peptide synthetase; This family of the adenylation (A) domain of nonribosomal ...

3099-3183

1.42e-34

Pssm-ID: 341304 [Multi-domain] Cd Length: 450 Bit Score: 140.20 E-value: 1.42e-34

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3099 PTAPALAFGEERLDYAELNRRANRLAHALIERGIGADRLVGVAMERSIEMVVALMAILKAGGAYVPVDPEYPEERQAYML 3178
Cdd:cd17649      1 PDAVALVFGDQSLSYAELDARANRLAHRLRALGVGPEVRVGIALERSLEMVVALLAILKAGGAYVPLDPEYPAERLRYML 80


                   ....*
gi 2183974163 3179 EDSGV 3183
Cdd:cd17649     81 EDSGA 85

PRK03640

o-succinylbenzoate--CoA ligase;

1581-2071

5.68e-34

o-succinylbenzoate--CoA ligase;

Pssm-ID: 235146 [Multi-domain] Cd Length: 483 Bit Score: 138.94 E-value: 5.68e-34

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1581 RPRATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGYM 1660
Cdd:PRK03640    15 TPDRTAIEFEEKKVTFMELHEAVVSVAGKLAALGVKKGDRVALLMKNGMEMILVIHALQQLGAVAVLLNTRLSREELLWQ 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1661 IEDSGIRLLLTQRAARERlpLGEGLPCLLLDAEHEwaGYPESDPQSAVGVDNLAYVIYTSGSTGKPKGTLLPHGNvlrlf 1740
Cdd:PRK03640    95 LDDAEVKCLITDDDFEAK--LIPGISVKFAELMNG--PKEEAEIQEEFDLDEVATIMYTSGTTGKPKGVIQTYGN----- 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1741 datrHWF---------GFSADDAW----SLFHSYAfdFSVweIFGALLHGGRLVIVPyetSRSPEDFLRLLCRERVTVLN 1807
Cdd:PRK03640   166 ----HWWsavgsalnlGLTEDDCWlaavPIFHISG--LSI--LMRSVIYGMRVVLVE---KFDAEKINKLLQTGGVTIIS 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1808 QTPSAFKQLMQVacAGQEVPPLALRHVVFGGEAlevqALRPWFERFGDRAPRLVNMYGITETTVH-VTYRPLSLADLDGG 1886
Cdd:PRK03640   235 VVSTMLQRLLER--LGEGTYPSSFRCMLLGGGP----APKPLLEQCKEKGIPVYQSYGMTETASQiVTLSPEDALTKLGS 308

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1887 AaspiGEPIPDLSWYLLDAGlNPVPRGCIGELYVGGAGLARGYLNRPElsctrfvADPFSTTGGRLYrTGDLARYRCDGV 1966
Cdd:PRK03640   309 A----GKPLFPCELKIEKDG-VVVPPFEEGEIVVKGPNVTKGYLNRED-------ATRETFQDGWFK-TGDIGYLDEEGF 375

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1967 VEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVV--LPHEGPGATQlVGYVVTQAAPSDpaalrDTLRQALKASLP 2044
Cdd:PRK03640   376 LYVLDRRSDLIISGGENIYPAEIEEVLLSHPGVAEAGVvgVPDDKWGQVP-VAFVVKSGEVTE-----EELRHFCEEKLA 449

                          490       500
                   ....*....|....*....|....*..
gi 2183974163 2045 EHMVPAHLLFLERLPLTANGKLDRRAL 2071
Cdd:PRK03640   450 KYKVPKRFYFVEELPRNASGKLLRHEL 476

FAA1

COG1022

Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism];

1562-2005

2.66e-33

Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism];

Pssm-ID: 440645 [Multi-domain] Cd Length: 603 Bit Score: 139.08 E-value: 2.66e-33

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1562 QDFTPASCLHRLIERQAAERPRATAVVY----GERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLA 1637
Cdd:COG1022      5 SDVPPADTLPDLLRRRAARFPDRVALREkedgIWQSLTWAEFAERVRALAAGLLALGVKPGDRVAILSDNRPEWVIADLA 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1638 ILKAGGAYVPLDPRYPSDRLGYMIEDSGIRLLLTQRAARER--LPLGEGLPCL----LLDAEHEW-------------AG 1698
Cdd:COG1022     85 ILAAGAVTVPIYPTSSAEEVAYILNDSGAKVLFVEDQEQLDklLEVRDELPSLrhivVLDPRGLRddprllsldellaLG 164

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1699 YPESDPQ------SAVGVDNLAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRHWFGFSADDAWSLF----HSYAFdfsVW 1768
Cdd:COG1022    165 REVADPAelearrAAVKPDDLATIIYTSGTTGRPKGVMLTHRNLLSNARALLERLPLGPGDRTLSFlplaHVFER---TV 241

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1769 EIFgALLHGGRLVIVPyetsrSPEDFLRLLcRE-RVTVLNQTP-----------------SAFKQLM---------QVAC 1821
Cdd:COG1022    242 SYY-ALAAGATVAFAE-----SPDTLAEDL-REvKPTFMLAVPrvwekvyagiqakaeeaGGLKRKLfrwalavgrRYAR 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1822 A---GQEVPP-LALRHVVFggEALevqALRPWFERFGDR-----------APRL--------VNM---YGITETTVHVTY 1875
Cdd:COG1022    315 ArlaGKSPSLlLRLKHALA--DKL---VFSKLREALGGRlrfavsggaalGPELarffralgIPVlegYGLTETSPVITV 389

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1876 RPLSLADLDGgaaspIGEPIPDLSWYLLDAglnpvprgciGELYVGGAGLARGYLNRPELSCTRFVADPFsttggrlYRT 1955
Cdd:COG1022    390 NRPGDNRIGT-----VGPPLPGVEVKIAED----------GEILVRGPNVMKGYYKNPEATAEAFDADGW-------LHT 447

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2183974163 1956 GDLARYRCDGVVEYVGRIDHQVKIR-GFRIELGEIEARLLAQPGVAEAVVL 2005
Cdd:COG1022    448 GDIGELDEDGFLRITGRKKDLIVTSgGKNVAPQPIENALKASPLIEQAVVV 498

PRK06164

acyl-CoA synthetase; Validated

515-1007

2.94e-33

acyl-CoA synthetase; Validated

Pssm-ID: 235722 [Multi-domain] Cd Length: 540 Bit Score: 137.95 E-value: 2.94e-33

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  515 LFEAQAGLTPDAPALLFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQY 594
Cdd:PRK06164    15 LLDAHARARPDAVALIDEDRPLSRAELRALVDRLAAWLAAQGVRRGDRVAVWLPNCIEWVVLFLACARLGATVIAVNTRY 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  595 PADRLQYMIDDSGLRLLL----------------SQQSVLARLPQ--------SDGLQSLLLDDLERLVHGYPAENPDL- 649
Cdd:PRK06164    95 RSHEVAHILGRGRARWLVvwpgfkgidfaailaaVPPDALPPLRAiavvddaaDATPAPAPGARVQLFALPDPAPPAAAg 174

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  650 -PEAPDSLCYAIYT-SGSTGQPKGVMVRHRALTNFVCSIARQPGMLARDRLLSVTTFSfDIFGLE-LYVPLARGASMLLa 726
Cdd:PRK06164   175 eRAADPDAGALLFTtSGTTSGPKLVLHRQATLLRHARAIARAYGYDPGAVLLAALPFC-GVFGFStLLGALAGGAPLVC- 252

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  727 srEQAQDPEALLDLVERQGVTVLQATPATWRMLCDSERVDLLRGCTLLCGGEALA---EDLAARMRGLSASTWNLYGPTE 803
Cdd:PRK06164   253 --EPVFDAARTARALRRHRVTHTFGNDEMLRRILDTAGERADFPSARLFGFASFApalGELAALARARGVPLTGLYGSSE 330

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  804 ----------TTIWSARFRLGeearpflGGPLENTA-LYILDSEMNP-CPPGVAGELLIGGDGLARGYHRRPGLTAERFL 871
Cdd:PRK06164   331 vqalvalqpaTDPVSVRIEGG-------GRPASPEArVRARDPQDGAlLPDGESGEIEIRAPSLMRGYLDNPDATARALT 403

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  872 PDPFaadgsrlYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQPGVAGPTLVAYLVP 951
Cdd:PRK06164   404 DDGY-------FRTGDLGYTRGDGQFVYQTRMGDSLRLGGFLVNPAEIEHALEALPGVAAAQVVGATRDGKTVPVAFVIP 476

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2183974163  952 TeaalvDAESARQQELRSALKNSLLAvlpdYMVPAHMLLLENLPLTPNG---KINRKAL 1007
Cdd:PRK06164   477 T-----DGASPDEAGLMAACREALAG----FKVPARVQVVEAFPVTESAngaKIQKHRL 526

PRK07470

acyl-CoA synthetase; Validated

524-1007

2.95e-33

acyl-CoA synthetase; Validated

Pssm-ID: 180988 [Multi-domain] Cd Length: 528 Bit Score: 137.87 E-value: 2.95e-33

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  524 PDAPALLFGEERLSYAELNALANRLAWRLREEGV--GSDVLVGIAleRGVPMVVALLAVLKAGGAYVPLDPQYPADRLQY 601
Cdd:PRK07470    21 PDRIALVWGDRSWTWREIDARVDALAAALAARGVrkGDRILVHSR--NCNQMFESMFAAFRLGAVWVPTNFRQTPDEVAY 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  602 MIDDSGLRLLLSQ----QSVLARLPQSDGLQSLLLDDLERLVHGYPA---ENPDLPEAP-----DSLCYAIYTSGSTGQP 669
Cdd:PRK07470    99 LAEASGARAMICHadfpEHAAAVRAASPDLTHVVAIGGARAGLDYEAlvaRHLGARVANaavdhDDPCWFFFTSGTTGRP 178

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  670 KGVMVRHRAL----TNFVCSIArqPGMLARDRLLSVTTFSFDIfGLELYVPLARGA-SMLLASREqaQDPEALLDLVERQ 744
Cdd:PRK07470   179 KAAVLTHGQMafviTNHLADLM--PGTTEQDASLVVAPLSHGA-GIHQLCQVARGAaTVLLPSER--FDPAEVWALVERH 253

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  745 GVTVLQATPATWRMLCDSERVDLLRGCTL----LCGGEALAEDLAARMRGLSASTWNLYGPTETT----IWSARF----- 811
Cdd:PRK07470   254 RVTNLFTVPTILKMLVEHPAVDRYDHSSLryviYAGAPMYRADQKRALAKLGKVLVQYFGLGEVTgnitVLPPALhdaed 333

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  812 ----RLGEEARPFLGgplenTALYILDSEMNPCPPGVAGELLIGGDGLARGYHRRPGLTAERFlpdpfaADGsrLYRTGD 887
Cdd:PRK07470   334 gpdaRIGTCGFERTG-----MEVQIQDDEGRELPPGETGEICVIGPAVFAGYYNNPEANAKAF------RDG--WFRTGD 400

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  888 LARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQP-GVAGPTLVAYLVPTEAALVDAEsarqqe 966
Cdd:PRK07470   401 LGHLDARGFLYITGRASDMYISGGSNVYPREIEEKLLTHPAVSEVAVLGVPdPVWGEVGVAVCVARDGAPVDEA------ 474

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|.
gi 2183974163  967 lrsALKNSLLAVLPDYMVPAHMLLLENLPLTPNGKINRKAL 1007
Cdd:PRK07470   475 ---ELLAWLDGKVARYKLPKRFFFWDALPKSGYGKITKKMV 512

OSB_MenE-like

cd17630

O-succinylbenzoic acid-CoA ligase; This family contains O-succinylbenzoyl-CoA (OSB-CoA) ...

655-1007

5.14e-33

O-succinylbenzoic acid-CoA ligase; This family contains O-succinylbenzoyl-CoA (OSB-CoA) synthetase (also known as O-succinylbenzoic acid CoA ligase) that belongs to the ANL superfamily and catalyzes the ligation of CoA to o-succinylbenzoate (OSB). It includes MenE in the bacterial menaquinone biosynthesis pathway which is a promising target for the development of novel antibacterial agents. MenE catalyzes CoA ligation via an acyl-adenylate intermediate; tight-binding inhibitors of MenE based on stable acyl-sulfonyladenosine analogs of this intermediate provide a pathway toward the development of optimized MenE inhibitors.

Pssm-ID: 341285 [Multi-domain] Cd Length: 325 Bit Score: 132.45 E-value: 5.14e-33

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  655 SLCYAIYTSGSTGQPKGVMVRHRALTNFVCSIARQPGMLARDRLLsVTTFSFDIFGLE-LYVPLARGASMLLASREQAqd 733
Cdd:cd17630      1 RLATVILTSGSTGTPKAVVHTAANLLASAAGLHSRLGFGGGDSWL-LSLPLYHVGGLAiLVRSLLAGAELVLLERNQA-- 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  734 peALLDLvERQGVTVLQATPATWRMLCDS----ERVDLLRGctLLCGGEALAEDLAARMRGLSASTWNLYGPTETTIWSA 809
Cdd:cd17630     78 --LAEDL-APPGVTHVSLVPTQLQRLLDSgqgpAALKSLRA--VLLGGAPIPPELLERAADRGIPLYTTYGMTETASQVA 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  810 RFRLGEEARPFLGGPLENTALYILDsemnpcppgvAGELLIGGDGLARGYHRRPgltaerfLPDPFAADGsrLYRTGDLA 889
Cdd:cd17630    153 TKRPDGFGRGGVGVLLPGRELRIVE----------DGEIWVGGASLAMGYLRGQ-------LVPEFNEDG--WFTTKDLG 213

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  890 RYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVaqpGVAGPTLVAYLVpteAALVDAESARQQELRS 969
Cdd:cd17630    214 ELHADGRLTVLGRADNMIISGGENIQPEEIEAALAAHPAVRDAFVV---GVPDEELGQRPV---AVIVGRGPADPAELRA 287

                          330       340       350
                   ....*....|....*....|....*....|....*...
gi 2183974163  970 ALKNSllavLPDYMVPAHMLLLENLPLTPNGKINRKAL 1007
Cdd:cd17630    288 WLKDK----LARFKLPKRIYPVPELPRTGGGKVDRRAL 321

ACS-like

cd17634

acetate-CoA ligase; This family includes acyl- and aryl-CoA ligases, as well as the ...

524-1002

5.46e-33

Pssm-ID: 341289 [Multi-domain] Cd Length: 587 Bit Score: 138.09 E-value: 5.46e-33

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  524 PDAPALLF-GEE-----RLSYAELNALANRLAWRLREEGVGSDVLVGIALergvPMV----VALLAVLKAGGAYVPLDPQ 593
Cdd:cd17634     67 GDRTAIIYeGDDtsqsrTISYRELHREVCRFAGTLLDLGVKKGDRVAIYM----PMIpeaaVAMLACARIGAVHSVIFGG 142

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  594 YPADRLQYMIDDSGLRLLLSQQSVL--------------ARLPQSDGLQSLLLDDLER---------------LVHGYPA 644
Cdd:cd17634    143 FAPEAVAGRIIDSSSRLLITADGGVragrsvplkknvddALNPNVTSVEHVIVLKRTGsdidwqegrdlwwrdLIAKASP 222

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  645 ENPDLPEAPDSLCYAIYTSGSTGQPKGVMVRH-----RALTNFVCSIARQPG---MLARDrLLSVTTFSFDIFGlelyvP 716
Cdd:cd17634    223 EHQPEAMNAEDPLFILYTSGTTGKPKGVLHTTggylvYAATTMKYVFDYGPGdiyWCTAD-VGWVTGHSYLLYG-----P 296

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  717 LARGASMLL-ASREQAQDPEALLDLVERQGVTVLQATPATWRMLCDS-----ERVDLLRGCTLLCGGEALAEDLAA---- 786
Cdd:cd17634    297 LACGATTLLyEGVPNWPTPARMWQVVDKHGVNILYTAPTAIRALMAAgddaiEGTDRSSLRILGSVGEPINPEAYEwywk 376

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  787 RMRGLSASTWNLYGPTETT--IWSAR-----FRLGEEARPFLGgplenTALYILDSEMNPCPPGVAGELLIGGD--GLAR 857
Cdd:cd17634    377 KIGKEKCPVVDTWWQTETGgfMITPLpgaieLKAGSATRPVFG-----VQPAVVDNEGHPQPGGTEGNLVITDPwpGQTR 451

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  858 GYHRRPgltaERFLPDPFAA-DGsrLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVA 936
Cdd:cd17634    452 TLFGDH----ERFEQTYFSTfKG--MYFSGDGARRDEDGYYWITGRSDDVINVAGHRLGTAEIESVLVAHPKVAEAAVVG 525

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2183974163  937 QP-GVAGPTLVAYLVpTEAALVDAESARqQELRSALKNSLLAVLpdymVPAHMLLLENLPLTPNGKI 1002
Cdd:cd17634    526 IPhAIKGQAPYAYVV-LNHGVEPSPELY-AELRNWVRKEIGPLA----TPDVVHWVDSLPKTRSGKI 586

A_NRPS_LgrA-like

cd17645

adenylation (A) domain of linear gramicidin synthetase (LgrA) and similar proteins; This ...

3088-3183

6.10e-33

Pssm-ID: 341300 [Multi-domain] Cd Length: 440 Bit Score: 134.99 E-value: 6.10e-33

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3088 HRLFEEQVERTPTAPALAFGEERLDYAELNRRANRLAHALIERGIGADRLVGVAMERSIEMVVALMAILKAGGAYVPVDP 3167
Cdd:cd17645      1 HQLFEEQVERTPDHVAVVDRGQSLTYKQLNEKANQLARHLRGKGVKPDDQVGIMLDKSLDMIAAILGVLKAGGAYVPIDP 80

                           90
                   ....*....|....*.
gi 2183974163 3168 EYPEERQAYMLEDSGV 3183
Cdd:cd17645     81 DYPGERIAYMLADSSA 96

OSB_MenE-like

cd17630

O-succinylbenzoic acid-CoA ligase; This family contains O-succinylbenzoyl-CoA (OSB-CoA) ...

1713-2071

7.23e-33

Pssm-ID: 341285 [Multi-domain] Cd Length: 325 Bit Score: 132.07 E-value: 7.23e-33

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1713 LAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRHWFGFSADDAW----SLFH--SYAFdfsvweIFGALLHGGRLVIVPYE 1786
Cdd:cd17630      2 LATVILTSGSTGTPKAVVHTAANLLASAAGLHSRLGFGGGDSWllslPLYHvgGLAI------LVRSLLAGAELVLLERN 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1787 tsrspEDFLRLLCRERVTVLNQTPSAFKQLMQvacAGQEVPPLA-LRHVVFGGEALEVQALrpwfERFGDRAPRLVNMYG 1865
Cdd:cd17630     76 -----QALAEDLAPPGVTHVSLVPTQLQRLLD---SGQGPAALKsLRAVLLGGAPIPPELL----ERAADRGIPLYTTYG 143

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1866 ITETTVHVTyrplsLADLDGGAASPIGEPIPDlswylldAGLNPVPRGCIGelyVGGAGLARGYLNRPELsctrfvaDPF 1945
Cdd:cd17630    144 MTETASQVA-----TKRPDGFGRGGVGVLLPG-------RELRIVEDGEIW---VGGASLAMGYLRGQLV-------PEF 201

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1946 STTGgrLYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVVLPHEGPGATQLVGYVVTQAAP 2025
Cdd:cd17630    202 NEDG--WFTTKDLGELHADGRLTVLGRADNMIISGGENIQPEEIEAALAAHPAVRDAFVVGVPDEELGQRPVAVIVGRGP 279

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*.
gi 2183974163 2026 SDPAAlrdtLRQALKASLPEHMVPAHLLFLERLPLTANGKLDRRAL 2071
Cdd:cd17630    280 ADPAE----LRAWLKDKLARFKLPKRIYPVPELPRTGGGKVDRRAL 321

PRK06087

medium-chain fatty-acid--CoA ligase;

537-1007

8.97e-33

medium-chain fatty-acid--CoA ligase;

Pssm-ID: 180393 [Multi-domain] Cd Length: 547 Bit Score: 136.80 E-value: 8.97e-33

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  537 SYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQYMIDDSGLRLLLSQQ- 615
Cdd:PRK06087    51 TYSALDHAASRLANWLLAKGIEPGDRVAFQLPGWCEFTIIYLACLKVGAVSVPLLPSWREAELVWVLNKCQAKMFFAPTl 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  616 -----------SVLARLPQsdgLQSLLLDD----------LERLVHGYPAENPDLPEAPDSLCYAIYTSGSTGQPKGVMV 674
Cdd:PRK06087   131 fkqtrpvdlilPLQNQLPQ---LQQIVGVDklapatsslsLSQIIADYEPLTTAITTHGDELAAVLFTSGTEGLPKGVML 207

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  675 RHRALtnfvcsIARQPGMLARdrlLSVTtfSFDIFGLElyVPL--ARG------ASMLLASREQAQD---PEALLDLVER 743
Cdd:PRK06087   208 THNNI------LASERAYCAR---LNLT--WQDVFMMP--APLghATGflhgvtAPFLIGARSVLLDiftPDACLALLEQ 274

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  744 QGVT-VLQATPATWRMLC--DSERVDL--LRgcTLLCGGEALAEDLAARMRGLSASTWNLYGPTETtIWSARFRLGEEAR 818
Cdd:PRK06087   275 QRCTcMLGATPFIYDLLNllEKQPADLsaLR--FFLCGGTTIPKKVARECQQRGIKLLSVYGSTES-SPHAVVNLDDPLS 351

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  819 PFL---GGPLENTALYILDSEMNPCPPGVAGELLIGGDGLARGYHRRPGLTAeRFLPDpfaaDGsrLYRTGDLARYRADG 895
Cdd:PRK06087   352 RFMhtdGYAAAGVEIKVVDEARKTLPPGCEGEEASRGPNVFMGYLDEPELTA-RALDE----EG--WYYSGDLCRMDEAG 424

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  896 VIEYLGRiDHQVKIRGFR-IELGEIETRLLEQDSVREAVVVAQPGV-AGPTLVAYLVPTEaalvdaesarqQELRSALKN 973
Cdd:PRK06087   425 YIKITGR-KKDIIVRGGEnISSREVEDILLQHPKIHDACVVAMPDErLGERSCAYVVLKA-----------PHHSLTLEE 492

                          490       500       510
                   ....*....|....*....|....*....|....*....
gi 2183974163  974 sLLAVL-----PDYMVPAHMLLLENLPLTPNGKINRKAL 1007
Cdd:PRK06087   493 -VVAFFsrkrvAKYKYPEHIVVIDKLPRTASGKIQKFLL 530

PRK06145

acyl-CoA synthetase; Validated

523-1007

9.33e-33

acyl-CoA synthetase; Validated

Pssm-ID: 102207 [Multi-domain] Cd Length: 497 Bit Score: 135.78 E-value: 9.33e-33

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  523 TPDAPALLFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQYM 602
Cdd:PRK06145    15 TPDRAALVYRDQEISYAEFHQRILQAAGMLHARGIGQGDVVALLMKNSAAFLELAFAASYLGAVFLPINYRLAADEVAYI 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  603 IDDSGLRLLLSQQSVLArlPQSDGLQSLLLD-----DLERLVHGYPAENPDLPEAPDSLCYAIYTSGSTGQPKGVMVRHr 677
Cdd:PRK06145    95 LGDAGAKLLLVDEEFDA--IVALETPKIVIDaaaqaDSRRLAQGGLEIPPQAAVAPTDLVRLMYTSGTTDRPKGVMHSY- 171

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  678 alTNFVCSIARQP---GMLARDRLLSVTTF----SFDIFGLELyvpLARGAsMLLASREqaQDPEALLDLVERQGVTVLQ 750
Cdd:PRK06145   172 --GNLHWKSIDHVialGLTASERLLVVGPLyhvgAFDLPGIAV---LWVGG-TLRIHRE--FDPEAVLAAIERHRLTCAW 243

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  751 ATPA-TWRMLC--DSERVDLLRGCTLLCGGEALAEdlaARMRGLS-----ASTWNLYGPTETTIWSARFRLGEEARPF-- 820
Cdd:PRK06145   244 MAPVmLSRVLTvpDRDRFDLDSLAWCIGGGEKTPE---SRIRDFTrvftrARYIDAYGLTETCSGDTLMEAGREIEKIgs 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  821 LGGPLENTALYILDSEMNPCPPGVAGELLIGGDGLARGYHRRPGLTAERFLPDPFaadgsrlyRTGDLARYRADGVIEYL 900
Cdd:PRK06145   321 TGRALAHVEIRIADGAGRWLPPNMKGEICMRGPKVTKGYWKDPEKTAEAFYGDWF--------RSGDVGYLDEEGFLYLT 392

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  901 GRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQPGVA-GPTLVAYLVPTEAALVDAEsarqqelrsALKNSLLAVL 979
Cdd:PRK06145   393 DRKKDMIISGGENIASSEVERVIYELPEVAEAAVIGVHDDRwGERITAVVVLNPGATLTLE---------ALDRHCRQRL 463

                          490       500
                   ....*....|....*....|....*...
gi 2183974163  980 PDYMVPAHMLLLENLPLTPNGKINRKAL 1007
Cdd:PRK06145   464 ASFKVPRQLKVRDELPRNPSGKVLKRVL 491

PRK05605

long-chain-fatty-acid--CoA ligase; Validated

1557-2069

1.30e-32

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 235531 [Multi-domain] Cd Length: 573 Bit Score: 136.67 E-value: 1.30e-32

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1557 WNPGPQDFTPASCLHrLIERQAAERPRATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLL 1636
Cdd:PRK05605    22 WTPHDLDYGDTTLVD-LYDNAVARFGDRPALDFFGATTTYAELGKQVRRAAAGLRALGVRPGDRVAIVLPNCPQHIVAFY 100

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1637 AILKAGGAYVPLDPRYPSDRLGYMIEDSGIRL---------------------------------LLTQ----------R 1673
Cdd:PRK05605   101 AVLRLGAVVVEHNPLYTAHELEHPFEDHGARVaivwdkvaptverlrrttpletivsvnmiaampLLQRlalrlpipalR 180

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1674 AARERL--PLGEGLPC-LLLDAEHEWAGYPESDPqsAVGVDNLAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRHWFGFS 1750
Cdd:PRK05605   181 KARAALtgPAPGTVPWeTLVDAAIGGDGSDVSHP--RPTPDDVALILYTSGTTGKPKGAQLTHRNLFANAAQGKAWVPGL 258

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1751 ADD------AWSLFHSY------AFDFSVweifgallhGGRLVIVPyeTSRSPEdFLRLLCRERVTVLNQTPSAFKQLMQ 1818
Cdd:PRK05605   259 GDGpervlaALPMFHAYgltlclTLAVSI---------GGELVLLP--APDIDL-ILDAMKKHPPTWLPGVPPLYEKIAE 326

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1819 VAcAGQEVPPLALRHVVFGGEALEVQALRPWFERFGDrapRLVNMYGITETTVHVTYRPLSladlDGGAASPIGEPIPDL 1898
Cdd:PRK05605   327 AA-EERGVDLSGVRNAFSGAMALPVSTVELWEKLTGG---LLVEGYGLTETSPIIVGNPMS----DDRRPGYVGVPFPDT 398

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1899 SWYLLDAGlNP---VPRGCIGELYVGGAGLARGYLNRPELSCTRFVADpfsttggrLYRTGDLARYRCDGVVEYVGRIDH 1975
Cdd:PRK05605   399 EVRIVDPE-DPdetMPDGEEGELLVRGPQVFKGYWNRPEETAKSFLDG--------WFRTGDVVVMEEDGFIRIVDRIKE 469

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1976 QVKIRGFRIELGEIEARLLAQPGVAEAVV--LPHEGPGATQLVGYVVTQAAPSDPAALRDTLRQALKAslpeHMVPAHLL 2053
Cdd:PRK05605   470 LIITGGFNVYPAEVEEVLREHPGVEDAAVvgLPREDGSEEVVAAVVLEPGAALDPEGLRAYCREHLTR----YKVPRRFY 545

                          570
                   ....*....|....*.
gi 2183974163 2054 FLERLPLTANGKLDRR 2069
Cdd:PRK05605   546 HVDELPRDQLGKVRRR 561

A_NRPS_Cytc1-like

similar to adenylation domain of cytotrienin synthetase CytC1; This family of the adenylation ...

3099-3183

3.51e-32

Pssm-ID: 341298 [Multi-domain] Cd Length: 450 Bit Score: 133.20 E-value: 3.51e-32

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3099 PTAPALAFGEERLDYAELNRRANRLAHALIERGIGADRLVGVAMERSIEMVVALMAILKAGGAYVPVDPEYPEERQAYML 3178
Cdd:cd17643      1 PEAVAVVDEDRRLTYGELDARANRLARTLRAEGVGPGDRVALALPRSAELIVALLAILKAGGAYVPIDPAYPVERIAFIL 80


                   ....*
gi 2183974163 3179 EDSGV 3183
Cdd:cd17643     81 ADSGP 85

FACL_like_2

cd05917

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ...

653-1004

1.39e-31

Pssm-ID: 341241 [Multi-domain] Cd Length: 349 Bit Score: 128.93 E-value: 1.39e-31

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  653 PDSLCYAIYTSGSTGQPKGVMVRHRALTNFVCSIARQPGMLARDRLLSVTTFsFDIFGLELYV--PLARGASMLLASReq 730
Cdd:cd05917      1 PDDVINIQFTSGTTGSPKGATLTHHNIVNNGYFIGERLGLTEQDRLCIPVPL-FHCFGSVLGVlaCLTHGATMVFPSP-- 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  731 AQDPEALLDLVERQGVTVLQATPAtwrMLCDS------ERVDLLRGCTLLCGGEALAEDLAARMR---GLSASTwNLYGP 801
Cdd:cd05917     78 SFDPLAVLEAIEKEKCTALHGVPT---MFIAElehpdfDKFDLSSLRTGIMAGAPCPPELMKRVIevmNMKDVT-IAYGM 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  802 TETTIWSARFRLGEEARPFL---GGPLENTALYILDSEMNP-CPPGVAGELLIGGDGLARGYHRRPGLTAErflpdpfAA 877
Cdd:cd05917    154 TETSPVSTQTRTDDSIEKRVntvGRIMPHTEAKIVDPEGGIvPPVGVPGELCIRGYSVMKGYWNDPEKTAE-------AI 226

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  878 DGSRLYRTGDLARYRADGVIEYLGRIDHQVkIRGFR-IELGEIETRLLEQDSVREAVVVaqpGVA----GPTLVAYLVPT 952
Cdd:cd05917    227 DGDGWLHTGDLAVMDEDGYCRIVGRIKDMI-IRGGEnIYPREIEEFLHTHPKVSDVQVV---GVPderyGEEVCAWIRLK 302

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2183974163  953 EAALVDAEsarqqELRSALKNSLLAvlpdYMVPAHMLLLENLPLTPNGKINR 1004
Cdd:cd05917    303 EGAELTEE-----DIKAYCKGKIAH----YKVPRYVFFVDEFPLTVSGKIQK 345

PRK06060

p-hydroxybenzoic acid--AMP ligase FadD22;

1573-2180

1.58e-31

p-hydroxybenzoic acid--AMP ligase FadD22;

Pssm-ID: 180374 [Multi-domain] Cd Length: 705 Bit Score: 134.77 E-value: 1.58e-31

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1573 LIERQAAE-----RPrataVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVP 1647
Cdd:PRK06060     9 LLAEQASEagwydRP----AFYAADVVTHGQIHDGAARLGEVLRNRGLSSGDRVLLCLPDSPDLVQLLLACLARGVMAFL 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1648 LDPRYPSDRLGYMIEDSGIRLLLTQRAARERLPLGEGLPCLLLDAEHEWAGYPESDPqsaVGVDNLAYVIYTSGSTGKPK 1727
Cdd:PRK06060    85 ANPELHRDDHALAARNTEPALVVTSDALRDRFQPSRVAEAAELMSEAARVAPGGYEP---MGGDALAYATYTSGTTGPPK 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1728 GTLLPHGNVLRLFDAT-RHWFGFSADD----AWSLFHSYAFDFSVWeifGALLHGGRLVIVPYETSrsPEDFLRLLCRER 1802
Cdd:PRK06060   162 AAIHRHADPLTFVDAMcRKALRLTPEDtglcSARMYFAYGLGNSVW---FPLATGGSAVINSAPVT--PEAAAILSARFG 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1803 VTVLNQTPSAFKQLMQvACAGQEVPplALRHVVFGGEALEVQALRPWFERFGDraprLVNMYGITETTVHVTYRPLSLAD 1882
Cdd:PRK06060   237 PSVLYGVPNFFARVID-SCSPDSFR--SLRCVVSAGEALELGLAERLMEFFGG----IPILDGIGSTEVGQTFVSNRVDE 309

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1883 LDGGAaspIGEPIPDLSWYLLDAGLNPVPRGCIGELYVGGAGLARGYLNRPelsctrfvaDPFSTTGGRLyRTGDLARYR 1962
Cdd:PRK06060   310 WRLGT---LGRVLPPYEIRVVAPDGTTAGPGVEGDLWVRGPAIAKGYWNRP---------DSPVANEGWL-DTRDRVCID 376

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1963 CDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAE-AVVLPHEGPGATQLVGYVV-TQAAPSDPAALRDTLRQALk 2040
Cdd:PRK06060   377 SDGWVTYRCRADDTEVIGGVNVDPREVERLIIEDEAVAEaAVVAVRESTGASTLQAFLVaTSGATIDGSVMRDLHRGLL- 455

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2041 ASLPEHMVPAHLLFLERLPLTANGKLDRRALPA--------------------------PDASRLQRDYTAPRSELEQRL 2094
Cdd:PRK06060   456 NRLSAFKVPHRFAVVDRLPRTPNGKLVRGALRKqsptkpiwelsltepgsgvraqrddlSASNMTIAGGNDGGATLRERL 535

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2095 A------------AIWADVLKL------GRVGLDDNFFELGGDSIISIQVVSR-ARQAGIRLAPRDLFLHQTIRGLAG-V 2154
Cdd:PRK06060   536 ValrqerqrlvvdAVCAEAAKMlgepdpWSVDQDLAFSELGFDSQMTVTLCKRlAAVTGLRLPETVGWDYGSISGLAQyL 615

                          650       660
                   ....*....|....*....|....*....
gi 2183974163 2155 AVEGRGLACAEQGPI---SGSTPLLPIQQ 2180
Cdd:PRK06060   616 EAELAGGHGRLKSAGpvnSGATGLWAIEE 644

AAS_C

cd05909

C-terminal domain of the acyl-acyl carrier protein synthetase (also called ...

1711-2071

2.66e-31

C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Acyl-acyl carrier protein synthase (Aas) is a membrane protein responsible for a minor pathway of incorporating exogenous fatty acids into membrane phospholipids. Its in vitro activity is characterized by the ligation of free fatty acids between 8 and 18 carbons in length to the acyl carrier protein sulfydryl group (ACP-SH) in the presence of ATP and Mg2+. However, its in vivo function is as a 2-acylglycerophosphoethanolamine (2-acyl-GPE) acyltransferase. The reaction occurs in two steps: the acyl chain is first esterified to acyl carrier protein (ACP) via a thioester bond, followed by a second step where the acyl chain is transferred to a 2-acyllysophospholipid, thus completing the transacylation reaction. This model represents the C-terminal domain of the enzyme, which belongs to the class I adenylate-forming enzyme family, including acyl-CoA synthetases.

Pssm-ID: 341235 [Multi-domain] Cd Length: 490 Bit Score: 131.30 E-value: 2.66e-31

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1711 DNLAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRHWFGFSADD----AWSLFHSYAFDFSVWEifgALLHGGRLVIVPYE 1786
Cdd:cd05909    147 DDPAVILFTSGSEGLPKGVVLSHKNLLANVEQITAIFDPNPEDvvfgALPFFHSFGLTGCLWL---PLLSGIKVVFHPNP 223

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1787 TsrSPEDFLRLLCRERVTVLNQTPSaFkqLMQVACAGQEVPPLALRHVVFGGEALEVQALRPWFERFGdraPRLVNMYGI 1866
Cdd:cd05909    224 L--DYKKIPELIYDKKATILLGTPT-F--LRGYARAAHPEDFSSLRLVVAGAEKLKDTLRQEFQEKFG---IRILEGYGT 295

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1867 TETTVHVTyrpLSLADLDGGAASpIGEPIPDLSWYLLD-AGLNPVPRGCIGELYVGGAGLARGYLNRPELscTRFVAdpf 1945
Cdd:cd05909    296 TECSPVIS---VNTPQSPNKEGT-VGRPLPGMEVKIVSvETHEEVPIGEGGLLLVRGPNVMLGYLNEPEL--TSFAF--- 366

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1946 sttGGRLYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIE---ARLLAQPGVAEAVVLPHEGPGATQLVGYVvtq 2022
Cdd:cd05909    367 ---GDGWYDTGDIGKIDGEGFLTITGRLSRFAKIAGEMVSLEAIEdilSEILPEDNEVAVVSVPDGRKGEKIVLLTT--- 440

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2023 aapsDPAALRDTLRQALKAS-LPEHMVPAHLLFLERLPLTANGKLDRRAL 2071
Cdd:cd05909    441 ----TTDTDPSSLNDILKNAgISNLAKPSYIHQVEEIPLLGTGKPDYVTL 486

PRK09088

acyl-CoA synthetase; Validated

1577-2071

3.26e-31

acyl-CoA synthetase; Validated

Pssm-ID: 181644 [Multi-domain] Cd Length: 488 Bit Score: 130.70 E-value: 3.26e-31

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1577 QAAERPRATAVV--YGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPS 1654
Cdd:PRK09088     4 HARLQPQRLAAVdlALGRRWTYAELDALVGRLAAVLRRRGCVDGERLAVLARNSVWLVALHFACARVGAIYVPLNWRLSA 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1655 DRLGYMIEDSGIRLLLTQRAARERLPLGEGLPCLLLDAEHEwagypESDPQSAVGVDNLAYVIYTSGSTGKPKGTLLPHG 1734
Cdd:PRK09088    84 SELDALLQDAEPRLLLGDDAVAAGRTDVEDLAAFIASADAL-----EPADTPSIPPERVSLILFTSGTSGQPKGVMLSER 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1735 NVlrlfDATRHWFGFSAD-DAWSLFHSYAFDFS----VWEIFGALLHGGRLVIVP-YETSRSpedfLRLLCRERVTVLNQ 1808
Cdd:PRK09088   159 NL----QQTAHNFGVLGRvDAHSSFLCDAPMFHiiglITSVRPVLAVGGSILVSNgFEPKRT----LGRLGDPALGITHY 230

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1809 TpsAFKQLMQVACAGQEVPPLALRH---VVFGGEALEVQALRPWFerfgDRAPRLVNMYGITETTVhVTYRPLSLADLDG 1885
Cdd:PRK09088   231 F--CVPQMAQAFRAQPGFDAAALRHltaLFTGGAPHAAEDILGWL----DDGIPMVDGFGMSEAGT-VFGMSVDCDVIRA 303

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1886 GAASPiGEPIPDLSWYLLDAGLNPVPRGCIGELYVGGAGLARGYLNRPELSCTRFVADPFsttggrlYRTGDLARYRCDG 1965
Cdd:PRK09088   304 KAGAA-GIPTPTVQTRVVDDQGNDCPAGVPGELLLRGPNLSPGYWRRPQATARAFTGDGW-------FRTGDIARRDADG 375

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1966 VVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVVLPHEGPGATQlVGYVVTQAAPSDPAALRDtLRQALKASLPE 2045
Cdd:PRK09088   376 FFWVVDRKKDMFISGGENVYPAEIEAVLADHPGIRECAVVGMADAQWGE-VGYLAIVPADGAPLDLER-IRSHLSTRLAK 453

                          490       500
                   ....*....|....*....|....*.
gi 2183974163 2046 HMVPAHLLFLERLPLTANGKLDRRAL 2071
Cdd:PRK09088   454 YKVPKHLRLVDALPRTASGKLQKARL 479

PRK06060

p-hydroxybenzoic acid--AMP ligase FadD22;

518-1090

3.27e-31

p-hydroxybenzoic acid--AMP ligase FadD22;

Pssm-ID: 180374 [Multi-domain] Cd Length: 705 Bit Score: 133.62 E-value: 3.27e-31

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  518 AQAGLTpDAPALlFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPAD 597
Cdd:PRK06060    15 SEAGWY-DRPAF-YAADVVTHGQIHDGAARLGEVLRNRGLSSGDRVLLCLPDSPDLVQLLLACLARGVMAFLANPELHRD 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  598 RLQYMIDDSGLRLLLSQQSVLARLPQSDglqslLLDDLERLVHGYPAENPDL-PEAPDSLCYAIYTSGSTGQPKGVMVRH 676
Cdd:PRK06060    93 DHALAARNTEPALVVTSDALRDRFQPSR-----VAEAAELMSEAARVAPGGYePMGGDALAYATYTSGTTGPPKAAIHRH 167

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  677 RALTNFVCSIARQPGMLA-RDRLLSVTTFSFdIFGL--ELYVPLARGASMLLASREQAQDPEALLDlvERQGVTVLQATP 753
Cdd:PRK06060   168 ADPLTFVDAMCRKALRLTpEDTGLCSARMYF-AYGLgnSVWFPLATGGSAVINSAPVTPEAAAILS--ARFGPSVLYGVP 244

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  754 ATWRMLCDSERVDLLRGC-TLLCGGEALAEDLAARMRGLSASTWNLYGPTETTIWSARFRLG-EEARP-FLGGPLENTAL 830
Cdd:PRK06060   245 NFFARVIDSCSPDSFRSLrCVVSAGEALELGLAERLMEFFGGIPILDGIGSTEVGQTFVSNRvDEWRLgTLGRVLPPYEI 324

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  831 YILDSEMNPCPPGVAGELLIGGDGLARGYHRRPgltaerflpDPFAADGSRLyRTGDLARYRADGVIEYLGRIDHQVKIR 910
Cdd:PRK06060   325 RVVAPDGTTAGPGVEGDLWVRGPAIAKGYWNRP---------DSPVANEGWL-DTRDRVCIDSDGWVTYRCRADDTEVIG 394

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  911 GFRIELGEIETRLLEQDSVREAVVVAQPGVAG-PTLVAYLVPTEAALVDAESARQQELRsalknsLLAVLPDYMVPAHML 989
Cdd:PRK06060   395 GVNVDPREVERLIIEDEAVAEAAVVAVRESTGaSTLQAFLVATSGATIDGSVMRDLHRG------LLNRLSAFKVPHRFA 468

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  990 LLENLPLTPNGKINRKAL-------PL-------------------PDASAVRDAHVAPEGELERAMAAIWSEVLKL--- 1040
Cdd:PRK06060   469 VVDRLPRTPNGKLVRGALrkqsptkPIwelsltepgsgvraqrddlSASNMTIAGGNDGGATLRERLVALRQERQRLvvd 548

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2183974163 1041 ---------------GHIGRDDNFFELGGHSLLVTQVVSRVRRRLDLQVPLRTLFEHSTLRAYAQ 1090
Cdd:PRK06060   549 avcaeaakmlgepdpWSVDQDLAFSELGFDSQMTVTLCKRLAAVTGLRLPETVGWDYGSISGLAQ 613

PRK06839

o-succinylbenzoate--CoA ligase;

510-1007

3.65e-31

o-succinylbenzoate--CoA ligase;

Pssm-ID: 168698 [Multi-domain] Cd Length: 496 Bit Score: 130.75 E-value: 3.65e-31

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  510 QGVHRLFEAQAGLTPDAPALLFGEERLSYAELNALANRLAWRLREE-GVGSDVLVGIALERGVPMVVALLAVLKAGGAYV 588
Cdd:PRK06839     2 QGIAYWIEKRAYLHPDRIAIITEEEEMTYKQLHEYVSKVAAYLIYElNVKKGERIAILSQNSLEYIVLLFAIAKVECIAV 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  589 PLDPQYPADRLQYMIDDSGLRLLLSQ---QSVLARLPQSDGLQSLL-LDDLERLVHgypAENPDLPEAPDSLCYAI-YTS 663
Cdd:PRK06839    82 PLNIRLTENELIFQLKDSGTTVLFVEktfQNMALSMQKVSYVQRVIsITSLKEIED---RKIDNFVEKNESASFIIcYTS 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  664 GSTGQPKG-VMVRHRALTNFVCSIArQPGMLARDRLLSVTTFsFDIFGLELYV--PLARGASMLLASReqaQDPEALLDL 740
Cdd:PRK06839   159 GTTGKPKGaVLTQENMFWNALNNTF-AIDLTMHDRSIVLLPL-FHIGGIGLFAfpTLFAGGVIIVPRK---FEPTKALSM 233

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  741 VERQGVTVLQATPATWRMLCDS---ERVDLLRGCTLLCGGEALAEDL--AARMRGLSASTWnlYGPTETTiwSARFRLGE 815
Cdd:PRK06839   234 IEKHKVTVVMGVPTIHQALINCskfETTNLQSVRWFYNGGAPCPEELmrEFIDRGFLFGQG--FGMTETS--PTVFMLSE 309

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  816 E--ARPF--LGGPLENTALYILDSEMNPCPPGVAGELLIGGDGLARGYHRRPGLTAERFlpdpfaADGsrLYRTGDLARY 891
Cdd:PRK06839   310 EdaRRKVgsIGKPVLFCDYELIDENKNKVEVGEVGELLIRGPNVMKEYWNRPDATEETI------QDG--WLCTGDLARV 381

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  892 RADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQPGVA-GPTLVAYLVPTEAALVDAESarqqelrsa 970
Cdd:PRK06839   382 DEDGFVYIVGRKKEMIISGGENIYPLEVEQVINKLSDVYEVAVVGRQHVKwGEIPIAFIVKKSSSVLIEKD--------- 452

                          490       500       510
                   ....*....|....*....|....*....|....*..
gi 2183974163  971 LKNSLLAVLPDYMVPAHMLLLENLPLTPNGKINRKAL 1007
Cdd:PRK06839   453 VIEHCRLFLAKYKIPKEIVFLKELPKNATGKIQKAQL 489

CBAL

cd05923

4-Chlorobenzoate-CoA ligase (CBAL); CBAL catalyzes the conversion of 4-chlorobenzoate (4-CB) ...

510-1007

5.45e-31

Pssm-ID: 341247 [Multi-domain] Cd Length: 493 Bit Score: 130.32 E-value: 5.45e-31

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  510 QGVHRLFEAQAGLTPDAPALLF--GEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAY 587
Cdd:cd05923      1 QTVFEMLRRAASRAPDACAIADpaRGLRLTYSELRARIEAVAARLHARGLRPGQRVAVVLPNSVEAVIALLALHRLGAVP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  588 VPLDPQYPADRLQYMIDDSGLRLLLSQqsVLARLPQSD---GLQSLLLDDLERLVHGYPAEN--PDLPEAPDSLCYAIYT 662
Cdd:cd05923     81 ALINPRLKAAELAELIERGEMTAAVIA--VDAQVMDAIfqsGVRVLALSDLVGLGEPESAGPliEDPPREPEQPAFVFYT 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  663 SGSTGQPKGVMVRHRALTNFVCSIARQPGML--ARDRLLSVTTFSFDI--FGLeLYVPLARGASMLLAsreQAQDPEALL 738
Cdd:cd05923    159 SGTTGLPKGAVIPQRAAESRVLFMSTQAGLRhgRHNVVLGLMPLYHVIgfFAV-LVAALALDGTYVVV---EEFDPADAL 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  739 DLVERQGVTVLQATPATWRMLCDSE-----RVDLLRgcTLLCGGEALAEDLAARM-RGLSASTWNLYGPTE--TTIWSAR 810
Cdd:cd05923    235 KLIEQERVTSLFATPTHLDALAAAAefaglKLSSLR--HVTFAGATMPDAVLERVnQHLPGEKVNIYGTTEamNSLYMRD 312

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  811 FRLGEEARPflGGPLENTALYILDSEMNPCPPGVAGELLI--GGDGLARGYHRRPGLTAERFlpdpfaADGsrLYRTGDL 888
Cdd:cd05923    313 ARTGTEMRP--GFFSEVRIVRIGGSPDEALANGEEGELIVaaAADAAFTGYLNQPEATAKKL------QDG--WYRTGDV 382

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  889 ARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVaqpGVA----GPTLVAYLVPTEAalvdaeSARQ 964
Cdd:cd05923    383 GYVDPSGDVRILGRVDDMIISGGENIHPSEIERVLSRHPGVTEVVVI---GVAderwGQSVTACVVPREG------TLSA 453

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|...
gi 2183974163  965 QELRSALKNSLLAvlpDYMVPAHMLLLENLPLTPNGKINRKAL 1007
Cdd:cd05923    454 DELDQFCRASELA---DFKRPRRYFFLDELPKNAMNKVLRRQL 493

PRK07788

acyl-CoA synthetase; Validated

1572-2075

7.54e-31

acyl-CoA synthetase; Validated

Pssm-ID: 236097 [Multi-domain] Cd Length: 549 Bit Score: 130.82 E-value: 7.54e-31

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1572 RLIERQAAERPRATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPR 1651
Cdd:PRK07788    53 GLVAHAARRAPDRAALIDERGTLTYAELDEQSNALARGLLALGVRAGDGVAVLARNHRGFVLALYAAGKVGARIILLNTG 132

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1652 YPSDRLGYMIEDSGIRLLLtqrAARERLPLGEGLPClLLDAEHEWAGYPESDPQSAVGVDNLA----------------- 1714
Cdd:PRK07788   133 FSGPQLAEVAAREGVKALV---YDDEFTDLLSALPP-DLGRLRAWGGNPDDDEPSGSTDETLDdliagsstaplpkppkp 208

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1715 --YVIYTSGSTGKPKGTLLPHGNVLRLFDATRHWFGFSADD----AWSLFHSYAfdFSVWEIfgALLHGGRLVivpyeTS 1788
Cdd:PRK07788   209 ggIVILTSGTTGTPKGAPRPEPSPLAPLAGLLSRVPFRAGEttllPAPMFHATG--WAHLTL--AMALGSTVV-----LR 279

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1789 R--SPEDFLRLLCRERVTVLNQTPSAFKQLMQVACAGQEVPPL-ALRHVVFGGEALEVQALRPWFERFGdraPRLVNMYG 1865
Cdd:PRK07788   280 RrfDPEATLEDIAKHKATALVVVPVMLSRILDLGPEVLAKYDTsSLKIIFVSGSALSPELATRALEAFG---PVLYNLYG 356

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1866 ITETTVHVTYRPLSLADldggAASPIGEPIPDLSWYLLDAGLNPVPRGCIGELYVGGAGLARGYlnrpelsctrfvadpf 1945
Cdd:PRK07788   357 STEVAFATIATPEDLAE----APGTVGRPPKGVTVKILDENGNEVPRGVVGRIFVGNGFPFEGY---------------- 416

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1946 stTGGR-------LYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVVL--PHEGPGAtQLV 2016
Cdd:PRK07788   417 --TDGRdkqiidgLLSSGDVGYFDEDGLLFVDGRDDDMIVSGGENVFPAEVEDLLAGHPDVVEAAVIgvDDEEFGQ-RLR 493

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2017 GYVVtqaaPSDPAAL-RDTLRQALKASLPEHMVPAHLLFLERLPLTANGKLDRRALPAPD 2075
Cdd:PRK07788   494 AFVV----KAPGAALdEDAIKDYVRDNLARYKVPRDVVFLDELPRNPTGKVLKRELREMD 549

MACS_like_2

cd05973

Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the ...

536-1007

7.64e-31

Pssm-ID: 341277 [Multi-domain] Cd Length: 437 Bit Score: 128.79 E-value: 7.64e-31

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  536 LSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQYMIDDSGLRLLLSQQ 615
Cdd:cd05973      1 LTFGELRALSARFANALQELGVGPGDVVAGLLPRTPELVVTILGIWRLGAVYQPLFTAFGPKAIEHRLRTSGARLVVTDA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  616 SVLARLpqsdglqsllldDLERLVHgypaenpdlpeapdslcyaIYTSGSTGQPKGVMVRHRALTNFVCSIARQPGMLAR 695
Cdd:cd05973     81 ANRHKL------------DSDPFVM-------------------MFTSGTTGLPKGVPVPLRALAAFGAYLRDAVDLRPE 129

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  696 DRLLSVTTFSFdIFGLELYV--PLARGASMLLAsrEQAQDPEALLDLVERQGVTVLQATPATWRML-CDSERVDLLRGCT 772
Cdd:cd05973    130 DSFWNAADPGW-AYGLYYAItgPLALGHPTILL--EGGFSVESTWRVIERLGVTNLAGSPTAYRLLmAAGAEVPARPKGR 206

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  773 LL---CGGEALAEDLAARMRG-LSASTWNLYGPTETTIWSAR-FRLGEEARP-FLGGPLENTALYILDSEMNPCPPGVAG 846
Cdd:cd05973    207 LRrvsSAGEPLTPEVIRWFDAaLGVPIHDHYGQTELGMVLANhHALEHPVHAgSAGRAMPGWRVAVLDDDGDELGPGEPG 286

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  847 ELLIGgdglargYHRRPGLTAERF-LPDPFAADGsRLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLE 925
Cdd:cd05973    287 RLAID-------IANSPLMWFRGYqLPDTPAIDG-GYYLTGDTVEFDPDGSFSFIGRADDVITMSGYRIGPFDVESALIE 358

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  926 QDSVREAVVVAQPG-VAGPTLVAYLVPTEAAlvDAESARQQELRSALKNSLLAvlpdYMVPAHMLLLENLPLTPNGKINR 1004
Cdd:cd05973    359 HPAVAEAAVIGVPDpERTEVVKAFVVLRGGH--EGTPALADELQLHVKKRLSA----HAYPRTIHFVDELPKTPSGKIQR 432


                   ...
gi 2183974163 1005 KAL 1007
Cdd:cd05973    433 FLL 435

PRK07786

long-chain-fatty-acid--CoA ligase; Validated

1574-2066

9.64e-31

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 169098 [Multi-domain] Cd Length: 542 Bit Score: 130.28 E-value: 9.64e-31

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1574 IERQAAERPRATAVVYGERALDYGELNLRANRLAHRLIELGVG-PDVLVGLAAERSlEMIVGLLAILKAGGAYVPLDPRY 1652
Cdd:PRK07786    23 LARHALMQPDAPALRFLGNTTTWRELDDRVAALAGALSRRGVGfGDRVLILMLNRT-EFVESVLAANMLGAIAVPVNFRL 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1653 PSDRLGYMIEDSGIRLLLTQ-------RAARERLPLGEGLPCLLLDAEHEWAGY----PESDPQSA---VGVDNLAYVIY 1718
Cdd:PRK07786   102 TPPEIAFLVSDCGAHVVVTEaalapvaTAVRDIVPLLSTVVVAGGSSDDSVLGYedllAEAGPAHApvdIPNDSPALIMY 181

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1719 TSGSTGKPKGTLLPHGNVL-RLFDATRHWFGFSADD----AWSLFHSYAfdfsVWEIFGALLHGGRLVIVPYEtSRSPED 1793
Cdd:PRK07786   182 TSGTTGRPKGAVLTHANLTgQAMTCLRTNGADINSDvgfvGVPLFHIAG----IGSMLPGLLLGAPTVIYPLG-AFDPGQ 256

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1794 FLRLLCRERVTVLNQTPSAFkqlmQVACAGQEVPP--LALRHVVFGGEALEVQALRPWFERFGDRAprLVNMYGITETTv 1871
Cdd:PRK07786   257 LLDVLEAEKVTGIFLVPAQW----QAVCAEQQARPrdLALRVLSWGAAPASDTLLRQMAATFPEAQ--ILAAFGQTEMS- 329

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1872 hvtyrPLSLAdLDGGAA----SPIGEPIPDLSWYLLDAGLNPVPRGCIGELYVGGAGLARGYLNRPELSctrfvADPFSt 1947
Cdd:PRK07786   330 -----PVTCM-LLGEDAirklGSVGKVIPTVAARVVDENMNDVPVGEVGEIVYRAPTLMSGYWNNPEAT-----AEAFA- 397

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1948 tgGRLYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVVL--PHEGPGATQLVgyVVTQAAP 2025
Cdd:PRK07786   398 --GGWFHSGDLVRQDEEGYVWVVDRKKDMIISGGENIYCAEVENVLASHPDIVEVAVIgrADEKWGEVPVA--VAAVRND 473

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|.
gi 2183974163 2026 SDPAALRDtLRQALKASLPEHMVPAHLLFLERLPLTANGKL 2066
Cdd:PRK07786   474 DAALTLED-LAEFLTDRLARYKHPKALEIVDALPRNPAGKV 513

Ac_CoA_lig_AcsA

TIGR02188

acetate--CoA ligase; This model describes acetate-CoA ligase (EC 6.2.1.1), also called ...

1574-2071

9.93e-31

acetate--CoA ligase; This model describes acetate-CoA ligase (EC 6.2.1.1), also called acetyl-CoA synthetase and acetyl-activating enzyme. It catalyzes the reaction ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA and belongs to the family of AMP-binding enzymes described by pfam00501.

Pssm-ID: 274022 [Multi-domain] Cd Length: 626 Bit Score: 131.22 E-value: 9.93e-31

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1574 IERQAAERPRATAVVY-GE-----RALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVP 1647
Cdd:TIGR02188   63 VDRHLEARPDKVAIIWeGDepgevRKITYRELHREVCRFANVLKSLGVKKGDRVAIYMPMIPEAAIAMLACARIGAIHSV 142

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1648 LDPRYPSDRLGYMIEDSGIRLLLTQRAARER---LPL------------------------GEGLPCLLLDAEHEW---- 1696
Cdd:TIGR02188  143 VFGGFSAEALADRINDAGAKLVITADEGLRGgkvIPLkaivdealekcpvsvehvlvvrrtGNPVVPWVEGRDVWWhdlm 222

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1697 AGYPESDPQSAVGVDNLAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRHW---------FGFSADDAWSLFHSYAfdfsv 1767
Cdd:TIGR02188  223 AKASAYCEPEPMDSEDPLFILYTSGSTGKPKGVLHTTGGYLLYAAMTMKYvfdikdgdiFWCTADVGWITGHSYI----- 297

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1768 weIFGALLHGGRLVIvpYE---TSRSPEDFLRLLCRERVTVLNQTPSAFKQLMQvacAGQEVP------PLALRHVVfgG 1838
Cdd:TIGR02188  298 --VYGPLANGATTVM--FEgvpTYPDPGRFWEIIEKHKVTIFYTAPTAIRALMR---LGDEWVkkhdlsSLRLLGSV--G 368

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1839 EALEVQALRPWFERFGDRAPRLVNMYGITETTVHVTyRPL-SLADLDGGAASPigePIPDLSWYLLDAGLNPVPrgcigE 1917
Cdd:TIGR02188  369 EPINPEAWMWYYKVVGKERCPIVDTWWQTETGGIMI-TPLpGATPTKPGSATL---PFFGIEPAVVDEEGNPVE-----G 439

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1918 LYVGGA--------GLARGYLNRPElsctRFVADPFSTTGGrLYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEI 1989
Cdd:TIGR02188  440 PGEGGYlvikqpwpGMLRTIYGDHE----RFVDTYFSPFPG-YYFTGDGARRDKDGYIWITGRVDDVINVSGHRLGTAEI 514

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1990 EARLLAQPGVAEAVVL--PHEGPGATqLVGYVVTQAAPSDPAALRDTLRQALKASLPEHMVPAHLLFLERLPLTANGKLD 2067
Cdd:TIGR02188  515 ESALVSHPAVAEAAVVgiPDDIKGQA-IYAFVTLKDGYEPDDELRKELRKHVRKEIGPIAKPDKIRFVPGLPKTRSGKIM 593


                   ....
gi 2183974163 2068 RRAL 2071
Cdd:TIGR02188  594 RRLL 597

PRK12406

long-chain-fatty-acid--CoA ligase; Provisional

1586-2074

1.07e-30

long-chain-fatty-acid--CoA ligase; Provisional

Pssm-ID: 183506 [Multi-domain] Cd Length: 509 Bit Score: 129.82 E-value: 1.07e-30

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1586 AVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGYMIEDSG 1665
Cdd:PRK12406     4 TIISGDRRRSFDELAQRAARAAGGLAALGVRPGDCVALLMRNDFAFFEAAYAAMRLGAYAVPVNWHFKPEEIAYILEDSG 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1666 IRLLLTQ----RAARERLPlgEGLPCLL------------LDAEH--------EWAGY-PESDPQSAVGVDNLAYVIYTS 1720
Cdd:PRK12406    84 ARVLIAHadllHGLASALP--AGVTVLSvptppeiaaayrISPALltppagaiDWEGWlAQQEPYDGPPVPQPQSMIYTS 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1721 GSTGKPKGtllphgnvLRLFDAT-----------RHWFGFSADD----AWSLFHS--YAFDFSvweifgALLHGGRLVIV 1783
Cdd:PRK12406   162 GTTGHPKG--------VRRAAPTpeqaaaaeqmrALIYGLKPGIrallTGPLYHSapNAYGLR------AGRLGGVLVLQ 227

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1784 P-YEtsrsPEDFLRLLCRERVTVLNQTPSAFKQLMQVACAGQEVPPLA-LRHVVFGGEALEVQALRPWFERFGdraPRLV 1861
Cdd:PRK12406   228 PrFD----PEELLQLIERHRITHMHMVPTMFIRLLKLPEEVRAKYDVSsLRHVIHAAAPCPADVKRAMIEWWG---PVIY 300

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1862 NMYGITETTVhVTYrplslADLDGGAASP--IGEPIPDLSWYLLDAGLNPVPRGCIGELYVGGAGLAR-GYLNRPElscT 1938
Cdd:PRK12406   301 EYYGSTESGA-VTF-----ATSEDALSHPgtVGKAAPGAELRFVDEDGRPLPQGEIGEIYSRIAGNPDfTYHNKPE---K 371

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1939 RFVADPfsttgGRLYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVV--LPHEGPGATqLV 2016
Cdd:PRK12406   372 RAEIDR-----GGFITSGDVGYLDADGYLFLCDRKRDMVISGGVNIYPAEIEAVLHAVPGVHDCAVfgIPDAEFGEA-LM 445

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2183974163 2017 GYVVTQA-APSDPAALRDTLrqalKASLPEHMVPAHLLFLERLPLTANGKLDRRALPAP 2074
Cdd:PRK12406   446 AVVEPQPgATLDEADIRAQL----KARLAGYKVPKHIEIMAELPREDSGKIFKRRLRDP 500

FAA1

COG1022

Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism];

503-956

1.14e-30

Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism];

Pssm-ID: 440645 [Multi-domain] Cd Length: 603 Bit Score: 130.99 E-value: 1.14e-30

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  503 ASEYPAGQGVHRLFEAQAGLTPDAPALLF----GEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALL 578
Cdd:COG1022      4 FSDVPPADTLPDLLRRRAARFPDRVALREkedgIWQSLTWAEFAERVRALAAGLLALGVKPGDRVAILSDNRPEWVIADL 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  579 AVLKAGGAYVPLDPQYPADRLQYMIDDSGLRLLL--SQQ------SVLARLPQ------------SDGLQSLLLDDLERL 638
Cdd:COG1022     84 AILAAGAVTVPIYPTSSAEEVAYILNDSGAKVLFveDQEqldkllEVRDELPSlrhivvldprglRDDPRLLSLDELLAL 163

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  639 vhGYPAENPDLPEA------PDSLCYAIYTSGSTGQPKGVMVRHRALTNFVCSIARQPGMLARDRLLSVTTFSFdIFG-- 710
Cdd:COG1022    164 --GREVADPAELEArraavkPDDLATIIYTSGTTGRPKGVMLTHRNLLSNARALLERLPLGPGDRTLSFLPLAH-VFErt 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  711 LELYVpLARGASMLLASreqaqDPEALLDLVERQGVTVLQATPATW---------------------------------R 757
Cdd:COG1022    241 VSYYA-LAAGATVAFAE-----SPDTLAEDLREVKPTFMLAVPRVWekvyagiqakaeeagglkrklfrwalavgrryaR 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  758 MLCDSERVDLL----------------------RGCTLLCGGEALAEDLAARMRGLSASTWNLYGPTET----TIWSA-R 810
Cdd:COG1022    315 ARLAGKSPSLLlrlkhaladklvfsklrealggRLRFAVSGGAALGPELARFFRALGIPVLEGYGLTETspviTVNRPgD 394

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  811 FRLGEearpfLGGPLENTALYILDSemnpcppgvaGELLIGGDGLARGYHRRPGLTAERFLPDPFaadgsrlYRTGDLAR 890
Cdd:COG1022    395 NRIGT-----VGPPLPGVEVKIAED----------GEILVRGPNVMKGYYKNPEATAEAFDADGW-------LHTGDIGE 452

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2183974163  891 YRADGVIEYLGRIDHQVKIR-GFRIELGEIETRLLEQDSVREAVVVAQpgvAGPTLVAYLVPTEAAL 956
Cdd:COG1022    453 LDEDGFLRITGRKKDLIVTSgGKNVAPQPIENALKASPLIEQAVVVGD---GRPFLAALIVPDFEAL 516

PRK06155

crotonobetaine/carnitine-CoA ligase; Provisional

1551-2071

1.29e-30

crotonobetaine/carnitine-CoA ligase; Provisional

Pssm-ID: 235719 [Multi-domain] Cd Length: 542 Bit Score: 129.88 E-value: 1.29e-30

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1551 RADLLQWNPGPQDFTPAS-CLHRLIERQAAERPRATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSL 1629
Cdd:PRK06155     3 PLGAGLAARAVDPLPPSErTLPAMLARQAERYPDRPLLVFGGTRWTYAEAARAAAAAAHALAAAGVKRGDRVALMCGNRI 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1630 EMIVGLLAILKAGGAYVPLDPRYPSDRLGYMIEDSGIRLLLTQRAARERL----PLGEGLPCL-LLDAEHEWA------- 1697
Cdd:PRK06155    83 EFLDVFLGCAWLGAIAVPINTALRGPQLEHILRNSGARLLVVEAALLAALeaadPGDLPLPAVwLLDAPASVSvpagwst 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1698 -GYPESD---PQSAVGVDNLAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRHWFGFSADDAW----SLFHSYAFDfsvwE 1769
Cdd:PRK06155   163 aPLPPLDapaPAAAVQPGDTAAILYTSGTTGPSKGVCCPHAQFYWWGRNSAEDLEIGADDVLyttlPLFHTNALN----A 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1770 IFGALLHGGRLVIVP-YETSRspedFLRLLCRERVTV-----------LNQTPSAFKQLMQVACA-GQEVPPlalrhvvf 1836
Cdd:PRK06155   239 FFQALLAGATYVLEPrFSASG----FWPAVRRHGATVtyllgamvsilLSQPARESDRAHRVRVAlGPGVPA-------- 306

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1837 ggealevQALRPWFERFGdraPRLVNMYGITETTVHVTyrpLSLADLDGGAAspiGEPIPDLSWYLLDAGLNPVPRGCIG 1916
Cdd:PRK06155   307 -------ALHAAFRERFG---VDLLDGYGSTETNFVIA---VTHGSQRPGSM---GRLAPGFEARVVDEHDQELPDGEPG 370

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1917 ELYVGGA---GLARGYLNRPELSCTRFVADPFsttggrlyRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARL 1993
Cdd:PRK06155   371 ELLLRADepfAFATGYFGMPEKTVEAWRNLWF--------HTGDRVVRDADGWFRFVDRIKDAIRRRGENISSFEVEQVL 442

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1994 LAQPGVAEAVV--LPHEGPGATQLVGYVVTQAAPSDPAALrdtLRQAlKASLPEHMVPAHLLFLERLPLTANGKLDRRAL 2071
Cdd:PRK06155   443 LSHPAVAAAAVfpVPSELGEDEVMAAVVLRDGTALEPVAL---VRHC-EPRLAYFAVPRYVEFVAALPKTENGKVQKFVL 518

C_PKS-NRPS

Condensation domain of hybrid polyketide synthetase/nonribosomal peptide synthetases (PKS ...

2639-2940

1.57e-30

Condensation domain of hybrid polyketide synthetase/nonribosomal peptide synthetases (PKS/NRPSs); Condensation (C) domains of nonribosomal peptide synthetases (NRPSs) catalyze peptide bond formation within (usually) large multi-modular enzymatic complexes. Hybrid PKS/NRPS create polymers containing both polyketide and amide linkages. C-domains typically have a conserved HHxxxD motif at the active site; mutations in this motif can abolish or diminish condensation activity. Most members of this subfamily have the typical C-domain HHxxxD motif, a few such as Monascus pilosus lovastatin nonaketide synthase MokA have a non-canonical HRxxxD motif in the C-domain and are unable to catalyze amide-bond formation. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long (with various activities such as antibiotic, antifungal, antitumor and immunosuppression). There are various subtypes of C-domains such as the LCL-type which catalyzes peptide bond formation between two L-amino acids, the DCL-type which links an L-amino acid to the D-amino acid at the end of a growing peptide, starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and heterocyclization (Cyc) domains which catalyze both peptide bond formation and cyclization of Cys, Ser, or Thr residues. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the epimerization (E) domain, the ester-bond forming C-domain, dual E/C (epimerization and condensation) domains, and the X-domain.

Pssm-ID: 380455 [Multi-domain] Cd Length: 421 Bit Score: 127.57 E-value: 1.57e-30

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2639 PLSPMQQGMLFHSLYQQNSGDYINQMRLDVEG-LDPQRFREAWQAALDAHEVLRSGFLW--------QGALEKP-LQLVR 2708
Cdd:cd19532      3 PMSFGQSRFWFLQQYLEDPTTFNVTFSYRLTGpLDVARLERAVRAVGQRHEALRTCFFTdpedgepmQGVLASSpLRLEH 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2709 KRVEVPFSVHDWRDRADLAEaldalaageaglgFELAEAPLLRLVLVRTGERRHHLIYTNHHILMDGWSNSQLLGEVLQR 2788
Cdd:cd19532     83 VQISDEAEVEEEFERLKNHV-------------YDLESGETMRIVLLSLSPTEHYLIFGYHHIAMDGVSFQIFLRDLERA 149

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2789 YRGETPSRSDGRYRDYIAwLQRQD--AGRTE---AFWKQRLQRLGEPTLLVPaFAH-GVRGAeghADRY------RQLDV 2856
Cdd:cd19532    150 YNGQPLLPPPLQYLDFAA-RQRQDyeSGALDedlAYWKSEFSTLPEPLPLLP-FAKvKSRPP---LTRYdthtaeRRLDA 224

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2857 TTSQRLAEFAREQKVT-----LntlvqAAWLILLQRFTGQDTVAFGATVSGRPAElrGIEEQIGLFINTLPVVASPCPEQ 2931
Cdd:cd19532    225 ALAARIKEASRKLRVTpfhfyL-----AALQVLLARLLDVDDICIGIADANRTDE--DFMETIGFFLNLLPLRFRRDPSQ 297


                   ....*....
gi 2183974163 2932 PIGDWLQAV 2940
Cdd:cd19532    298 TFADVLKET 306

VL_LC_FACS_like

cd05907

Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA ...

1590-2071

2.57e-30

Pssm-ID: 341233 [Multi-domain] Cd Length: 452 Bit Score: 127.33 E-value: 2.57e-30

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1590 GERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGYMIEDSGIRLL 1669
Cdd:cd05907      2 VWQPITWAEFAEEVRALAKGLIALGVEPGDRVAILSRNRPEWTIADLAILAIGAVPVPIYPTSSAEQIAYILNDSEAKAL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1670 LTqraarerlplgeglpcllldaehewagypeSDPqsavgvDNLAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRHWFGF 1749
Cdd:cd05907     82 FV------------------------------EDP------DDLATIIYTSGTTGRPKGVMLSHRNILSNALALAERLPA 125

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1750 SADDAWSLF----HSYAfdfSVWEIFGALLHGGRLVIVPyetsrSPEDFLRLLCRERVTVLNQTPSAFKQlMQVACAGQE 1825
Cdd:cd05907    126 TEGDRHLSFlplaHVFE---RRAGLYVPLLAGARIYFAS-----SAETLLDDLSEVRPTVFLAVPRVWEK-VYAAIKVKA 196

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1826 VPPLA-----------LRHVVFGGEALEVQALRpWFERFGdraprlVNM---YGITETTVHVTYRPlsLADLDGGAaspI 1891
Cdd:cd05907    197 VPGLKrklfdlavggrLRFAASGGAPLPAELLH-FFRALG------IPVyegYGLTETSAVVTLNP--PGDNRIGT---V 264

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1892 GEPIPDLSWYLLDAglnpvprgciGELYVGGAGLARGYLNRPELSCTRFVADPFsttggrlYRTGDLARYRCDGVVEYVG 1971
Cdd:cd05907    265 GKPLPGVEVRIADD----------GEILVRGPNVMLGYYKNPEATAEALDADGW-------LHTGDLGEIDEDGFLHITG 327

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1972 RI-DHQVKIRGFRIELGEIEARLLAQPGVAEAVVLpheGPGATQLVGYVV------------TQAAPSDPA------ALR 2032
Cdd:cd05907    328 RKkDLIITSGGKNISPEPIENALKASPLISQAVVI---GDGRPFLVALIVpdpealeawaeeHGIAYTDVAelaanpAVR 404

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*...
gi 2183974163 2033 DTLRQALK---ASLPEHMVPAHLLFLERLP------LTANGKLDRRAL 2071
Cdd:cd05907    405 AEIEAAVEaanARLSRYEQIKKFLLLPEPFtiengeLTPTLKLKRPVI 452

A_NRPS_PpsD_like

cd17650

similar to adenylation domain of plipastatin synthase (PpsD); This family of the adenylation ...

3099-3183

4.01e-30

Pssm-ID: 341305 [Multi-domain] Cd Length: 447 Bit Score: 126.81 E-value: 4.01e-30

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3099 PTAPALAFGEERLDYAELNRRANRLAHALIERGIGADRLVGVAMERSIEMVVALMAILKAGGAYVPVDPEYPEERQAYML 3178
Cdd:cd17650      1 PDAIAVSDATRQLTYRELNERANQLARTLRGLGVAPGSVVGVCADRSLDAIVGLLAVLKAGGAYVPIDPDYPAERLQYML 80


                   ....*
gi 2183974163 3179 EDSGV 3183
Cdd:cd17650     81 EDSGA 85

A_NRPS_TubE_like

cd05906

The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) ...

1559-2071

6.81e-30

The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) synthesizing toxins and antitumor agents; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino)-acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. This family includes NRPSs that synthesize toxins and antitumor agents; for example, TubE for Tubulysine, CrpA for cryptophycin, TdiA for terrequinone A, KtzG for kutzneride, and Vlm1/Vlm2 for Valinomycin. Nonribosomal peptide synthetases are large multifunctional enzymes which synthesize many therapeutically useful peptides. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and, in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.

Pssm-ID: 341232 [Multi-domain] Cd Length: 540 Bit Score: 127.78 E-value: 6.81e-30

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1559 PGPQDFTPASCLHRLieRQAAERPRATAVVY-----GERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIV 1633
Cdd:cd05906      2 LHRPEGAPRTLLELL--LRAAERGPTKGITYidadgSEEFQSYQDLLEDARRLAAGLRQLGLRPGDSVILQFDDNEDFIP 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1634 GLLAILKAGGAYVPLDP----RYPSDRLGYM-----IEDSGiRLLLTQRAARERLPLGE--GLPCLLLDAEHEWAGYPES 1702
Cdd:cd05906     80 AFWACVLAGFVPAPLTVpptyDEPNARLRKLrhiwqLLGSP-VVLTDAELVAEFAGLETlsGLPGIRVLSIEELLDTAAD 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1703 DPQSAVGVDNLAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRHWFGFSADDAwslfhsyafdFSVWEIF---GALLH--- 1776
Cdd:cd05906    159 HDLPQSRPDDLALLMLTSGSTGFPKAVPLTHRNILARSAGKIQHNGLTPQDV----------FLNWVPLdhvGGLVElhl 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1777 -----GGRLVIVPYETS-RSPEDFLRLLCRERVTVLNQTPSAFKQLMQVACagqEVPP-----LALRHVVFGGEALEVQA 1845
Cdd:cd05906    229 ravylGCQQVHVPTEEIlADPLRWLDLIDRYRVTITWAPNFAFALLNDLLE---EIEDgtwdlSSLRYLVNAGEAVVAKT 305

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1846 LRPW---FERFGDRAPRLVNMYGITETTVHVTY-RPLSLADLDGGAA-SPIGEPIPDLSWYLLDAGLNPVPRGCIGELYV 1920
Cdd:cd05906    306 IRRLlrlLEPYGLPPDAIRPAFGMTETCSGVIYsRSFPTYDHSQALEfVSLGRPIPGVSMRIVDDEGQLLPEGEVGRLQV 385

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1921 GGAGLARGYLNRPELSCTRFVADPFsttggrlYRTGDLArYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVA 2000
Cdd:cd05906    386 RGPVVTKGYYNNPEANAEAFTEDGW-------FRTGDLG-FLDNGNLTITGRTKDTIIVNGVNYYSHEIEAAVEEVPGVE 457

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2183974163 2001 E---AVVLPHEGPGATQL--VGYVVTQAAPSDPAALRDTLRQalKASLPEHMVPAHLLFLER--LPLTANGKLDRRAL 2071
Cdd:cd05906    458 PsftAAFAVRDPGAETEElaIFFVPEYDLQDALSETLRAIRS--VVSREVGVSPAYLIPLPKeeIPKTSLGKIQRSKL 533

FACL_like_2

cd05917

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ...

1718-2068

1.22e-29

Pssm-ID: 341241 [Multi-domain] Cd Length: 349 Bit Score: 123.16 E-value: 1.22e-29

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1718 YTSGSTGKPKGTLLPHGNVLRLFDATRHWFGFSADD----AWSLFHSYAfdfSVWEIFGALLHGGRLVIVpyETSRSPED 1793
Cdd:cd05917      9 FTSGTTGSPKGATLTHHNIVNNGYFIGERLGLTEQDrlciPVPLFHCFG---SVLGVLACLTHGATMVFP--SPSFDPLA 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1794 FLRLLCRERVTVLNQTPSAFkqlmqVACAGQ----EVPPLALRHVVFGGEALEVQALRPWFERFGdrAPRLVNMYGITET 1869
Cdd:cd05917     84 VLEAIEKEKCTALHGVPTMF-----IAELEHpdfdKFDLSSLRTGIMAGAPCPPELMKRVIEVMN--MKDVTIAYGMTET 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1870 TvHVTYRPLSLADLDGGAASpIGEPIPDLSWYLLDAGLNPVP-RGCIGELYVGGAGLARGYLNRPELscTRFVADpfstt 1948
Cdd:cd05917    157 S-PVSTQTRTDDSIEKRVNT-VGRIMPHTEAKIVDPEGGIVPpVGVPGELCIRGYSVMKGYWNDPEK--TAEAID----- 227

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1949 GGRLYRTGDLARYRCDGVVEYVGRIDHQVkIRGFR-IELGEIEARLLAQPGVAEAVV--LPHEGPGaTQLVGYVVTQAAP 2025
Cdd:cd05917    228 GDGWLHTGDLAVMDEDGYCRIVGRIKDMI-IRGGEnIYPREIEEFLHTHPKVSDVQVvgVPDERYG-EEVCAWIRLKEGA 305

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|...
gi 2183974163 2026 SdpaALRDTLRQALKASLPEHMVPAHLLFLERLPLTANGKLDR 2068
Cdd:cd05917    306 E---LTEEDIKAYCKGKIAHYKVPRYVFFVDEFPLTVSGKIQK 345

A_NRPS_SidN3_like

cd05918

The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); ...

3087-3182

1.34e-29

Pssm-ID: 341242 [Multi-domain] Cd Length: 481 Bit Score: 125.73 E-value: 1.34e-29

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3087 VHRLFEEQVERTPTAPALAFGEERLDYAELNRRANRLAHALIERGIGADRLVGVAMERSIEMVVALMAILKAGGAYVPVD 3166
Cdd:cd05918      1 VHDLIEERARSQPDAPAVCAWDGSLTYAELDRLSSRLAHHLRSLGVGPGVFVPLCFEKSKWAVVAMLAVLKAGGAFVPLD 80

                           90
                   ....*....|....*.
gi 2183974163 3167 PEYPEERQAYMLEDSG 3182
Cdd:cd05918     81 PSHPLQRLQEILQDTG 96

AMP-binding

AMP-binding enzyme;

3091-3183

1.98e-29

AMP-binding enzyme;

Pssm-ID: 459834 [Multi-domain] Cd Length: 417 Bit Score: 123.96 E-value: 1.98e-29

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3091 FEEQVERTPTAPALAFGE-ERLDYAELNRRANRLAHALIERGIGADRLVGVAMERSIEMVVALMAILKAGGAYVPVDPEY 3169
Cdd:pfam00501    1 LERQAARTPDKTALEVGEgRRLTYRELDERANRLAAGLRALGVGKGDRVAILLPNSPEWVVAFLACLKAGAVYVPLNPRL 80

                           90
                   ....*....|....
gi 2183974163 3170 PEERQAYMLEDSGV 3183
Cdd:pfam00501   81 PAEELAYILEDSGA 94

PRK05852

fatty acid--CoA ligase family protein;

1559-2071

3.20e-29

fatty acid--CoA ligase family protein;

Pssm-ID: 235625 [Multi-domain] Cd Length: 534 Bit Score: 125.77 E-value: 3.20e-29

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1559 PGPQDFTPAscLHRLIERQAAERPRATA-VVYGER-ALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLL 1636
Cdd:PRK05852     9 PMASDFGPR--IADLVEVAATRLPEAPAlVVTADRiAISYRDLARLVDDLAGQLTRSGLLPGDRVALRMGSNAEFVVALL 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1637 AILKAGGAYVPLDPRYPSDRLGYMIEDSGIRLLL-------------------TQRAARERLPlGEGLPCLLLDAehewA 1697
Cdd:PRK05852    87 AASRADLVVVPLDPALPIAEQRVRSQAAGARVVLidadgphdraepttrwwplTVNVGGDSGP-SGGTLSVHLDA----A 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1698 GYPESDPQSAVGV-DNLAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRHWFGFSADDA----WSLFHSYAFDFSVWeifg 1772
Cdd:PRK05852   162 TEPTPATSTPEGLrPDDAMIMFTGGTTGLPKMVPWTHANIASSVRAIITGYRLSPRDAtvavMPLYHGHGLIAALL---- 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1773 ALLHGGRLVIVPYETSRSPEDFLRLLCRERVTVLNQTPSAFKQLMQVAcAGQEVP--PLALRHVVFGGEALEVQALRPWF 1850
Cdd:PRK05852   238 ATLASGGAVLLPARGRFSAHTFWDDIKAVGATWYTAVPTIHQILLERA-ATEPSGrkPAALRFIRSCSAPLTAETAQALQ 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1851 ERFGdrAPrLVNMYGITETTVHVTYRPLSLADLD---GGAASPIGEPI-PDLSWYLLDAGlnPVPRGCIGELYVGGAGLA 1926
Cdd:PRK05852   317 TEFA--AP-VVCAFGMTEATHQVTTTQIEGIGQTenpVVSTGLVGRSTgAQIRIVGSDGL--PLPAGAVGEVWLRGTTVV 391

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1927 RGYLNRPELSCTRFvadpfstTGGRLyRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVVL- 2005
Cdd:PRK05852   392 RGYLGDPTITAANF-------TDGWL-RTGDLGSLSAAGDLSIRGRIKELINRGGEKISPERVEGVLASHPNVMEAAVFg 463

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2183974163 2006 -PHEGPGATqlVGYVVTQAAPSDPAAlrDTLRQALKASLPEHMVPAHLLFLERLPLTANGKLDRRAL 2071
Cdd:PRK05852   464 vPDQLYGEA--VAAVIVPRESAPPTA--EELVQFCRERLAAFEIPASFQEASGLPHTAKGSLDRRAV 526

DCL_NRPS

DCL-type Condensation domain of nonribosomal peptide synthetases (NRPSs), which catalyzes the ...

2174-2600

3.48e-29

Pssm-ID: 380465 [Multi-domain] Cd Length: 423 Bit Score: 123.47 E-value: 3.48e-29

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2174 PLLPIQQ-MFFE--LDIPRRQHWNQSVL-LEpgQALDGTLLETALQALLAHHDALRLGFRLEdgtWRAE-----HRAVEA 2244
Cdd:cd19543      3 PLSPMQEgMLFHslLDPGSGAYVEQMVItLE--GPLDPDRFRAAWQAVVDRHPILRTSFVWE---GLGEplqvvLKDRKL 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2245 G-EVLLWQQSVADGQ--ALEALAEQVQ-RSLDLGSGPLLRALLATLGDGSQRLLLVIHHLVVDGVSWRILLEDLQTAYRQ 2320
Cdd:cd19543     78 PwRELDLSHLSEAEQeaELEALAEEDReRGFDLARAPLMRLTLIRLGDDRYRLVWSFHHILLDGWSLPILLKELFAIYAA 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2321 LQAGQAVALPAKTSaFKAWAERLQAHARdgglEGERGYWLAQLEGVS--TELPCDDREGAQSVRHVRSARTELTEEATRR 2398
Cdd:cd19543    158 LGEGQPPSLPPVRP-YRDYIAWLQRQDK----EAAEAYWREYLAGFEepTPLPKELPADADGSYEPGEVSFELSAELTAR 232

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2399 LLQEApAAYRTQVNDLLLTALARVIGRWTGQADTLIQLEGHGREELFEDIDltRTVGWFTSLFPLR--LSPVAELGASIK 2476
Cdd:cd19543    233 LQELA-RQHGVTLNTVVQGAWALLLSRYSGRDDVVFGTTVSGRPAELPGIE--TMVGLFINTLPVRvrLDPDQTVLELLK 309

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2477 RI-KEQLRAIPHKGLGFGALRylgsaedraALAALPSPRI----TF-NYLGQFDGSFSADSSALfrpSADAAGSERDSDA 2550
Cdd:cd19543    310 DLqAQQLELREHEYVPLYEIQ---------AWSEGKQALFdhllVFeNYPVDESLEEEQDEDGL---RITDVSAEEQTNY 377

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2551 PLdNWLSLNGqvyaGRLGIDWSFSAARFSEASILRLADAYRDELLALIEH 2600
Cdd:cd19543    378 PL-TVVAIPG----EELTIKLSYDAEVFDEATIERLLGHLRRVLEQVAAN 422

PRK08276

long-chain-fatty-acid--CoA ligase; Validated

1583-2071

4.52e-29

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 236215 [Multi-domain] Cd Length: 502 Bit Score: 124.63 E-value: 4.52e-29

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1583 RATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGYMIE 1662
Cdd:PRK08276     1 PAVIMAPSGEVVTYGELEARSNRLAHGLRALGLREGDVVAILLENNPEFFEVYWAARRSGLYYTPINWHLTAAEIAYIVD 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1663 DSGIRLLLTQ-------RAARERLPLgeGLPCLLLDAEHE--WAGYPES-DPQSAVGVDNL---AYVIYTSGSTGKPKGT 1729
Cdd:PRK08276    81 DSGAKVLIVSaaladtaAELAAELPA--GVPLLLVVAGPVpgFRSYEEAlAAQPDTPIADEtagADMLYSSGTTGRPKGI 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1730 L--LPH-------GNVLRLFDAtrhWFGFSADDAW----SLFHSYAFDFSVWeifgALLHGGRLVIVPyetSRSPEDFLR 1796
Cdd:PRK08276   159 KrpLPGldpdeapGMMLALLGF---GMYGGPDSVYlspaPLYHTAPLRFGMS----ALALGGTVVVME---KFDAEEALA 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1797 LLCRERVTVLNQTPSAFKQLMQVAcagQEVPPL----ALRHVVFGGEALEVQALRPWFERFGdraPRLVNMYGITETTVh 1872
Cdd:PRK08276   229 LIERYRVTHSQLVPTMFVRMLKLP---EEVRARydvsSLRVAIHAAAPCPVEVKRAMIDWWG---PIIHEYYASSEGGG- 301

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1873 vtyrpLSLADLDGGAASP--IGEPIpDLSWYLLDAGLNPVPRGCIGELYVGGAGLARGYLNRPELSCTRFVADPFSTTG- 1949
Cdd:PRK08276   302 -----VTVITSEDWLAHPgsVGKAV-LGEVRILDEDGNELPPGEIGTVYFEMDGYPFEYHNDPEKTAAARNPHGWVTVGd 375

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1950 -GRLYRTGDLarYRCDgvveyvgRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVV--LPHEGPGatQLVGYVVTqaaPS 2026
Cdd:PRK08276   376 vGYLDEDGYL--YLTD-------RKSDMIISGGVNIYPQEIENLLVTHPKVADVAVfgVPDEEMG--ERVKAVVQ---PA 441

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*....
gi 2183974163 2027 DPAALRDTLRQALKASLPEH----MVPAHLLFLERLPLTANGKLDRRAL 2071
Cdd:PRK08276   442 DGADAGDALAAELIAWLRGRlahyKCPRSIDFEDELPRTPTGKLYKRRL 490

PRK03640

o-succinylbenzoate--CoA ligase;

519-1007

4.85e-29

o-succinylbenzoate--CoA ligase;

Pssm-ID: 235146 [Multi-domain] Cd Length: 483 Bit Score: 124.30 E-value: 4.85e-29

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  519 QAGLTPDAPALLFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADR 598
Cdd:PRK03640    11 RAFLTPDRTAIEFEEKKVTFMELHEAVVSVAGKLAALGVKKGDRVALLMKNGMEMILVIHALQQLGAVAVLLNTRLSREE 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  599 LQYMIDDSGLRLLLSQQSVLARLpqsDGLQSLLLDDLERLvhgyPAENPDLPEA--PDSLCYAIYTSGSTGQPKGVMVR- 675
Cdd:PRK03640    91 LLWQLDDAEVKCLITDDDFEAKL---IPGISVKFAELMNG----PKEEAEIQEEfdLDEVATIMYTSGTTGKPKGVIQTy 163

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  676 ----HRALtnfvcSIARQPGMLARDRLLSVTTFsFDIFGLELYV-PLARGASMLLasrEQAQDPEALLDLVERQGVTVLQ 750
Cdd:PRK03640   164 gnhwWSAV-----GSALNLGLTEDDCWLAAVPI-FHISGLSILMrSVIYGMRVVL---VEKFDAEKINKLLQTGGVTIIS 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  751 ATPAtwrMLCD-SERV------DLLRgCTLLCGGEALAEDL-AARMRGLsaSTWNLYGPTETTiwS---------ARFRL 813
Cdd:PRK03640   235 VVST---MLQRlLERLgegtypSSFR-CMLLGGGPAPKPLLeQCKEKGI--PVYQSYGMTETA--SqivtlspedALTKL 306

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  814 GEearpfLGGPLENTALYILDsEMNPCPPGVAGELLIGGDGLARGYHRRPGLTAERFlpdpfaADGsrLYRTGDLARYRA 893
Cdd:PRK03640   307 GS-----AGKPLFPCELKIEK-DGVVVPPFEEGEIVVKGPNVTKGYLNREDATRETF------QDG--WFKTGDIGYLDE 372

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  894 DGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVaqpGVAGPTLVAylVPTeAALVDAESARQQELRSALKN 973
Cdd:PRK03640   373 EGFLYVLDRRSDLIISGGENIYPAEIEEVLLSHPGVAEAGVV---GVPDDKWGQ--VPV-AFVVKSGEVTEEELRHFCEE 446

                          490       500       510
                   ....*....|....*....|....*....|....
gi 2183974163  974 SllavLPDYMVPAHMLLLENLPLTPNGKINRKAL 1007
Cdd:PRK03640   447 K----LAKYKVPKRFYFVEELPRNASGKLLRHEL 476

PRK04319

acetyl-CoA synthetase; Provisional

525-1017

4.87e-29

acetyl-CoA synthetase; Provisional

Pssm-ID: 235279 [Multi-domain] Cd Length: 570 Bit Score: 125.39 E-value: 4.87e-29

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  525 DAPALLF----GEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPL----DPQYPA 596
Cdd:PRK04319    59 DKVALRYldasRKEKYTYKELKELSNKFANVLKELGVEKGDRVFIFMPRIPELYFALLGALKNGAIVGPLfeafMEEAVR 138

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  597 DRLQymidDSGLRLLLSQQSVLARLPQsDGLQSL----LLDDLERLVHGYPAENPDLPEAPDSLCY--------AI--YT 662
Cdd:PRK04319   139 DRLE----DSEAKVLITTPALLERKPA-DDLPSLkhvlLVGEDVEEGPGTLDFNALMEQASDEFDIewtdredgAIlhYT 213

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  663 SGSTGQPKGV------MVRHRALTNFV----------CSIarQPGMlardrllsVTTFSFDIFGlelyvPLARGASMLLa 726
Cdd:PRK04319   214 SGSTGKPKGVlhvhnaMLQHYQTGKYVldlheddvywCTA--DPGW--------VTGTSYGIFA-----PWLNGATNVI- 277

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  727 sREQAQDPEALLDLVERQGVTVLQATPATWRML--CDSE---RVDL--LRgcTLLCGGEAL-AEDLAARMRGLSA---ST 795
Cdd:PRK04319   278 -DGGRFSPERWYRILEDYKVTVWYTAPTAIRMLmgAGDDlvkKYDLssLR--HILSVGEPLnPEVVRWGMKVFGLpihDN 354

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  796 WNLygpTET-TIWSARFRlGEEARP-FLGGPLENTALYILDSEMNPCPPGVAGELLI--GGDGLARGYHRRPGLTAERFL 871
Cdd:PRK04319   355 WWM---TETgGIMIANYP-AMDIKPgSMGKPLPGIEAAIVDDQGNELPPNRMGNLAIkkGWPSMMRGIWNNPEKYESYFA 430

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  872 PDpfaadgsrLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQPG-VAGPTLVAYLV 950
Cdd:PRK04319   431 GD--------WYVSGDSAYMDEDGYFWFQGRVDDVIKTSGERVGPFEVESKLMEHPAVAEAGVIGKPDpVRGEIIKAFVA 502

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  951 ------PTEAAlvdaesarQQELRSALKNSLLAvlpdYMVPAHMLLLENLPLTPNGKINR---KA----LPLPDASAVRD 1017
Cdd:PRK04319   503 lrpgyePSEEL--------KEEIRGFVKKGLGA----HAAPREIEFKDKLPKTRSGKIMRrvlKAwelgLPEGDLSTMED 570

AFD_YhfT-like

cd17633

fatty acid-CoA ligase VraA; This family of acyl-CoA ligases includes Bacillus subtilis YhfT, ...

1712-2068

1.47e-28

fatty acid-CoA ligase VraA; This family of acyl-CoA ligases includes Bacillus subtilis YhfT, as well as long-chain fatty acid-CoA ligase VraA, all of which are as yet to be characterized. These proteins belong to the adenylate-forming enzymes which catalyze an ATP-dependent two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein. The active site of the domain is located at the interface of a large N-terminal subdomain and a smaller C-terminal subdomain

Pssm-ID: 341288 [Multi-domain] Cd Length: 320 Bit Score: 119.05 E-value: 1.47e-28

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1712 NLAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRHWFGFSADDAWSLFHSYAFDFSVWEIFGALLHGGRLVIvpyETSRSP 1791
Cdd:cd17633      1 NPFYIGFTSGTTGLPKAYYRSERSWIESFVCNEDLFNISGEDAILAPGPLSHSLFLYGAISALYLGGTFIG---QRKFNP 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1792 EDFLRLLCRERVTVLNQTPSAFKQLMQVacagqEVPPLALRHVVFGGEALEVQAlrpwFERFGDRAPR--LVNMYGITET 1869
Cdd:cd17633     78 KSWIRKINQYNATVIYLVPTMLQALART-----LEPESKIKSIFSSGQKLFEST----KKKLKNIFPKanLIEFYGTSEL 148

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1870 TvHVTYRplsladLDGGAASP--IGEPIPDLSWYLLDAGlnpvpRGCIGELYVGGAGLARGYLNRPELSCTRFvadpfst 1947
Cdd:cd17633    149 S-FITYN------FNQESRPPnsVGRPFPNVEIEIRNAD-----GGEIGKIFVKSEMVFSGYVRGGFSNPDGW------- 209

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1948 tggrlYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVVL--PHEGPGATQLVGYVVTQAAp 2025
Cdd:cd17633    210 -----MSVGDIGYVDEEGYLYLVGRESDMIIIGGINIFPTEIESVLKAIPGIEEAIVVgiPDARFGEIAVALYSGDKLT- 283

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|...
gi 2183974163 2026 sdpaalRDTLRQALKASLPEHMVPAHLLFLERLPLTANGKLDR 2068
Cdd:cd17633    284 ------YKQLKRFLKQKLSRYEIPKKIIFVDSLPYTSSGKIAR 320

PRK05852

fatty acid--CoA ligase family protein;

499-1007

1.51e-28

fatty acid--CoA ligase family protein;

Pssm-ID: 235625 [Multi-domain] Cd Length: 534 Bit Score: 123.46 E-value: 1.51e-28

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  499 SRLPASEypAGQGVHRLFEAQAGLTPDAPALLFGEER--LSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVA 576
Cdd:PRK05852     7 AAPMASD--FGPRIADLVEVAATRLPEAPALVVTADRiaISYRDLARLVDDLAGQLTRSGLLPGDRVALRMGSNAEFVVA 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  577 LLAVLKAGGAYVPLDPQYPA----DRLQ------YMIDDSG--------LRLLLSQQSVLARLPQSDGLQSLLLDDLERL 638
Cdd:PRK05852    85 LLAASRADLVVVPLDPALPIaeqrVRSQaagarvVLIDADGphdraeptTRWWPLTVNVGGDSGPSGGTLSVHLDAATEP 164

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  639 VHGYPAenPDLPEAPDSLCyaIYTSGSTGQPKGVMVRHRALTNFVCSIARQPGMLARDRLLSVTTFsFDIFGL--ELYVP 716
Cdd:PRK05852   165 TPATST--PEGLRPDDAMI--MFTGGTTGLPKMVPWTHANIASSVRAIITGYRLSPRDATVAVMPL-YHGHGLiaALLAT 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  717 LARGASMLLASREQAQdPEALLDLVERQGVTVLQATPATWRMLCDSERVDLLRGCTLL------CGGEALAEDLAARMRG 790
Cdd:PRK05852   240 LASGGAVLLPARGRFS-AHTFWDDIKAVGATWYTAVPTIHQILLERAATEPSGRKPAAlrfirsCSAPLTAETAQALQTE 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  791 LSASTWNLYGPTETTIWSARFRL-----GEEARPFLGGPLENTA--LYILDSEMNPCPPGVAGELLIGGDGLARGYHRRP 863
Cdd:PRK05852   319 FAAPVVCAFGMTEATHQVTTTQIegigqTENPVVSTGLVGRSTGaqIRIVGSDGLPLPAGAVGEVWLRGTTVVRGYLGDP 398

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  864 GLTAERFlpdpfaADGsrLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQP-GVAG 942
Cdd:PRK05852   399 TITAANF------TDG--WLRTGDLGSLSAAGDLSIRGRIKELINRGGEKISPERVEGVLASHPNVMEAAVFGVPdQLYG 470

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2183974163  943 PTLVAYLVPTEAALVDAesarqQELRSALKNSLLAvlpdYMVPAHMLLLENLPLTPNGKINRKAL 1007
Cdd:PRK05852   471 EAVAAVIVPRESAPPTA-----EELVQFCRERLAA----FEIPASFQEASGLPHTAKGSLDRRAV 526

PRK06145

acyl-CoA synthetase; Validated

1578-2071

1.68e-28

acyl-CoA synthetase; Validated

Pssm-ID: 102207 [Multi-domain] Cd Length: 497 Bit Score: 122.69 E-value: 1.68e-28

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1578 AAERPRATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRL 1657
Cdd:PRK06145    12 ARRTPDRAALVYRDQEISYAEFHQRILQAAGMLHARGIGQGDVVALLMKNSAAFLELAFAASYLGAVFLPINYRLAADEV 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1658 GYMIEDSGIRLLLTQRAAreRLPLGEGLPCLLLDAEHEW------AGYPESDPQSAVGVDNLAYVIYTSGSTGKPKGTLL 1731
Cdd:PRK06145    92 AYILGDAGAKLLLVDEEF--DAIVALETPKIVIDAAAQAdsrrlaQGGLEIPPQAAVAPTDLVRLMYTSGTTDRPKGVMH 169

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1732 PHGNV-LRLFDATRHwFGFSADD----AWSLFHSYAFDFSVweiFGALLHGGRLVIvpyETSRSPEDFLRLLCRERVTVL 1806
Cdd:PRK06145   170 SYGNLhWKSIDHVIA-LGLTASErllvVGPLYHVGAFDLPG---IAVLWVGGTLRI---HREFDPEAVLAAIERHRLTCA 242

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1807 NQTPSAFKQLMqvACAGQEVPPL-ALRHVVFGGEALEVQALRPWFERFgdRAPRLVNMYGITETTVHVTyrpLSLADLDG 1885
Cdd:PRK06145   243 WMAPVMLSRVL--TVPDRDRFDLdSLAWCIGGGEKTPESRIRDFTRVF--TRARYIDAYGLTETCSGDT---LMEAGREI 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1886 GAASPIGEPIPDLSWYLLDAGLNPVPRGCIGELYVGGAGLARGYLNRPELSCTRFVADPFsttggrlyRTGDLARYRCDG 1965
Cdd:PRK06145   316 EKIGSTGRALAHVEIRIADGAGRWLPPNMKGEICMRGPKVTKGYWKDPEKTAEAFYGDWF--------RSGDVGYLDEEG 387

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1966 VVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVVL-PHEGPGATQLVGYVVTQAAPSdpaALRDTLRQALKASLP 2044
Cdd:PRK06145   388 FLYLTDRKKDMIISGGENIASSEVERVIYELPEVAEAAVIgVHDDRWGERITAVVVLNPGAT---LTLEALDRHCRQRLA 464

                          490       500
                   ....*....|....*....|....*..
gi 2183974163 2045 EHMVPAHLLFLERLPLTANGKLDRRAL 2071
Cdd:PRK06145   465 SFKVPRQLKVRDELPRNPSGKVLKRVL 491

ACS

cd05966

Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); ...

1555-2071

1.81e-28

Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Acetyl-CoA synthetase (ACS, EC 6.2.1.1, acetate#CoA ligase or acetate:CoA ligase (AMP-forming)) catalyzes the formation of acetyl-CoA from acetate, CoA, and ATP. Synthesis of acetyl-CoA is carried out in a two-step reaction. In the first step, the enzyme catalyzes the synthesis of acetyl-AMP intermediate from acetate and ATP. In the second step, acetyl-AMP reacts with CoA to produce acetyl-CoA. This enzyme is widely present in all living organisms. The activity of this enzyme is crucial for maintaining the required levels of acetyl-CoA, a key intermediate in many important biosynthetic and catabolic processes. Acetyl-CoA is used in the biosynthesis of glucose, fatty acids, and cholesterol. It can also be used in the production of energy in the citric acid cycle. Eukaryotes typically have two isoforms of acetyl-CoA synthetase, a cytosolic form involved in biosynthetic processes and a mitochondrial form primarily involved in energy generation.

Pssm-ID: 341270 [Multi-domain] Cd Length: 608 Bit Score: 124.21 E-value: 1.81e-28

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1555 LQWNPGPQDF-------TPASclHRLIERQAAERPRATAVVY-GE-----RALDYGELNLRANRLAHRLIELGVGPDVLV 1621
Cdd:cd05966     35 LDWSKGPPFIkwfeggkLNIS--YNCLDRHLKERGDKVAIIWeGDepdqsRTITYRELLREVCRFANVLKSLGVKKGDRV 112

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1622 GLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGYMIEDSGIRLLLTQRAARER---LPLG-------EGLP----C 1687
Cdd:cd05966    113 AIYMPMIPELVIAMLACARIGAVHSVVFAGFSAESLADRINDAQCKLVITADGGYRGgkvIPLKeivdealEKCPsvekV 192

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1688 LL---------------LDAEHEWAGYPESDPQSAVGVDNLAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRHW------ 1746
Cdd:cd05966    193 LVvkrtggevpmtegrdLWWHDLMAKQSPECEPEWMDSEDPLFILYTSGSTGKPKGVVHTTGGYLLYAATTFKYvfdyhp 272

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1747 ---FGFSADDAWSLFHSYAfdfsvweIFGALLHGGRLVIvpYE---TSRSPEDFLRLLCRERVTVLNQTPSAFKQLMQva 1820
Cdd:cd05966    273 ddiYWCTADIGWITGHSYI-------VYGPLANGATTVM--FEgtpTYPDPGRYWDIVEKHKVTIFYTAPTAIRALMK-- 341

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1821 cAGQEVPP------LALRHVVfgGEALEVQALRpWFERF--GDRAPrLVNMYGITETTVH-VTYRPlSLADLDGGAASPi 1891
Cdd:cd05966    342 -FGDEWVKkhdlssLRVLGSV--GEPINPEAWM-WYYEVigKERCP-IVDTWWQTETGGImITPLP-GATPLKPGSATR- 414

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1892 gePIPDLSWYLLDAGLNPVPRGCIGELYVGGA--GLARGYLNRPElsctRFVADPFSTTGGrLYRTGDLARYRCDGVVEY 1969
Cdd:cd05966    415 --PFFGIEPAILDEEGNEVEGEVEGYLVIKRPwpGMARTIYGDHE----RYEDTYFSKFPG-YYFTGDGARRDEDGYYWI 487

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1970 VGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVV--LPHEGPGATqLVGYVVTQAAPSDPAALRDTLRQALKASLPEHM 2047
Cdd:cd05966    488 TGRVDDVINVSGHRLGTAEVESALVAHPAVAEAAVvgRPHDIKGEA-IYAFVTLKDGEEPSDELRKELRKHVRKEIGPIA 566

                          570       580
                   ....*....|....*....|....
gi 2183974163 2048 VPAHLLFLERLPLTANGKLDRRAL 2071
Cdd:cd05966    567 TPDKIQFVPGLPKTRSGKIMRRIL 590

AA-adenyl-dom

amino acid adenylation domain; This model represents a domain responsible for the specific ...

3113-3183

2.34e-28

Pssm-ID: 273779 [Multi-domain] Cd Length: 409 Bit Score: 120.83 E-value: 2.34e-28

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2183974163 3113 YAELNRRANRLAHALIER-GIGADRLVGVAMERSIEMVVALMAILKAGGAYVPVDPEYPEERQAYMLEDSGV 3183
Cdd:TIGR01733    2 YRELDERANRLARHLRAAgGVGPGDRVAVLLERSAELVVAILAVLKAGAAYVPLDPAYPAERLAFILEDAGA 73

MACS_like_1

cd05974

Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the ...

1594-2071

2.50e-28

Pssm-ID: 341278 [Multi-domain] Cd Length: 432 Bit Score: 121.14 E-value: 2.50e-28

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1594 LDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPrypsdrlgymiedsgirlLLTQR 1673
Cdd:cd05974      1 VSFAEMSARSSRVANFLRSIGVGRGDRILLMLGNVVELWEAMLAAMKLGAVVIPATT------------------LLTPD 62

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1674 AARERLPLGEGLPCLLLDAEHEwagypeSDPQsavgvdnLAYviYTSGSTGKPKGTLLPHGNVLRLFDATRHWFGFSADD 1753
Cdd:cd05974     63 DLRDRVDRGGAVYAAVDENTHA------DDPM-------LLY--FTSGTTSKPKLVEHTHRSYPVGHLSTMYWIGLKPGD 127

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1754 AWSLFHSYAFDFSVWEIFGALLHGGRLVIVPYETSRSPEDFLRLLCRERVTVLNQTPSAFKQLMQVACAGQEVPplaLRH 1833
Cdd:cd05974    128 VHWNISSPGWAKHAWSCFFAPWNAGATVFLFNYARFDAKRVLAALVRYGVTTLCAPPTVWRMLIQQDLASFDVK---LRE 204

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1834 VVFGGEAL--EV--QALRPWFERFGDRaprlvnmYGITETTVHVTYRPLSLAdldggAASPIGEPIPDLSWYLLDAGLNP 1909
Cdd:cd05974    205 VVGAGEPLnpEVieQVRRAWGLTIRDG-------YGQTETTALVGNSPGQPV-----KAGSMGRPLPGYRVALLDPDGAP 272

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1910 VPRGCIGeLYVGG---AGLARGYLNRPELSCtrfvadpfSTTGGRLYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIEL 1986
Cdd:cd05974    273 ATEGEVA-LDLGDtrpVGLMKGYAGDPDKTA--------HAMRGGYYRTGDIAMRDEDGYLTYVGRADDVFKSSDYRISP 343

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1987 GEIEARLLAQPGVAEAVVLPheGPGATQLV---GYVV-TQAAPSDPAALRDTLRQALKASLPEHMVpAHLLFLErLPLTA 2062
Cdd:cd05974    344 FELESVLIEHPAVAEAAVVP--SPDPVRLSvpkAFIVlRAGYEPSPETALEIFRFSRERLAPYKRI-RRLEFAE-LPKTI 419


                   ....*....
gi 2183974163 2063 NGKLDRRAL 2071
Cdd:cd05974    420 SGKIRRVEL 428

PRK07638

acyl-CoA synthetase; Validated

1578-2071

4.09e-28

acyl-CoA synthetase; Validated

Pssm-ID: 236071 [Multi-domain] Cd Length: 487 Bit Score: 121.42 E-value: 4.09e-28

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1578 AAERPRATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVlVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRL 1657
Cdd:PRK07638    11 ASLQPNKIAIKENDRVLTYKDWFESVCKVANWLNEKESKNKT-IAILLENRIEFLQLFAGAAMAGWTCVPLDIKWKQDEL 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1658 GYMIEDSGIRLLLTQRAARERLPLGEGlPCLLLDaehEWAGYPESDPQSAVGVDNLA----YVIYTSGSTGKPKGTLLPH 1733
Cdd:PRK07638    90 KERLAISNADMIVTERYKLNDLPDEEG-RVIEID---EWKRMIEKYLPTYAPIENVQnapfYMGFTSGSTGKPKAFLRAQ 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1734 GNVLRLFDATRHWFGFSADD----AWSLFHSYaFdfsvweIFGAL--LHGGRLVIVpyETSRSPEDFLRLLCRERVTVLN 1807
Cdd:PRK07638   166 QSWLHSFDCNVHDFHMKREDsvliAGTLVHSL-F------LYGAIstLYVGQTVHL--MRKFIPNQVLDKLETENISVMY 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1808 QTPSAFKQLMQVacagQEVPPLALRHVVFGG--EALEVQALRPWFERFgdrapRLVNMYGITETTVhVTYrpLSLADLDG 1885
Cdd:PRK07638   237 TVPTMLESLYKE----NRVIENKMKIISSGAkwEAEAKEKIKNIFPYA-----KLYEFYGASELSF-VTA--LVDEESER 304

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1886 GAASpIGEPIPDLSWYLLDAGLNPVPRGCIGELYVGGAGLARGYLN----RPELSctrfvADPFSTtggrlyrTGDLARY 1961
Cdd:PRK07638   305 RPNS-VGRPFHNVQVRICNEAGEEVQKGEIGTVYVKSPQFFMGYIIggvlARELN-----ADGWMT-------VRDVGYE 371

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1962 RCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVVL--PHEGPGaTQLVGYVVTQAApsdpaalRDTLRQAL 2039
Cdd:PRK07638   372 DEEGFIYIVGREKNMILFGGINIFPEEIESVLHEHPAVDEIVVIgvPDSYWG-EKPVAIIKGSAT-------KQQLKSFC 443

                          490       500       510
                   ....*....|....*....|....*....|..
gi 2183974163 2040 KASLPEHMVPAHLLFLERLPLTANGKLDRRAL 2071
Cdd:PRK07638   444 LQRLSSFKIPKEWHFVDEIPYTNSGKIARMEA 475

FADD10

cd17635

adenylate forming domain, fatty acid CoA ligase (FadD10); This family contains long chain ...

1716-2068

4.75e-28

adenylate forming domain, fatty acid CoA ligase (FadD10); This family contains long chain fatty acid CoA ligases, including FadD10 which is involved in the synthesis of a virulence-related lipopeptide. FadD10 is a fatty acyl-AMP ligase (FAAL) that transfers fatty acids to an acyl carrier protein. Structures of FadD10 in apo- and complexed form with dodecanoyl-AMP, show a novel open conformation, facilitated by its unique inter-domain and intermolecular interactions, which is critical for the enzyme to carry out the acyl transfer onto the acyl carrier protein (Rv0100) rather than coenzyme A.

Pssm-ID: 341290 [Multi-domain] Cd Length: 340 Bit Score: 118.13 E-value: 4.75e-28

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1716 VIYTSGSTGKPKGTLLPHGN-VLRLFDATRHWFGFSADDAWSLFHSYAFDFSVWEIFGALLHGGRLVIvpYETSRSPEDF 1794
Cdd:cd17635      6 VIFTSGTTGEPKAVLLANKTfFAVPDILQKEGLNWVVGDVTYLPLPATHIGGLWWILTCLIHGGLCVT--GGENTTYKSL 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1795 LRLLCRERVTVLNQTPSAFKQLM-QVACAGQEVPplALRHVVFGGEALeVQALRPWFERFGDraPRLVNMYGITETTVhV 1873
Cdd:cd17635     84 FKILTTNAVTTTCLVPTLLSKLVsELKSANATVP--SLRLIGYGGSRA-IAADVRFIEATGL--TNTAQVYGLSETGT-A 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1874 TYRPLSLADLDGGAaspIGEPIPDLSWYLLDAGLNPVPRGCIGELYVGGAGLARGYLNRPELSCTRFVadpfsttGGRLY 1953
Cdd:cd17635    158 LCLPTDDDSIEINA---VGRPYPGVDVYLAATDGIAGPSASFGTIWIKSPANMLGYWNNPERTAEVLI-------DGWVN 227

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1954 rTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVV--LPHEGPGAtqLVGYVVTQAAPSDPAAL 2031
Cdd:cd17635    228 -TGDLGERREDGFLFITGRSSESINCGGVKIAPDEVERIAEGVSGVQECACyeISDEEFGE--LVGLAVVASAELDENAI 304

                          330       340       350
                   ....*....|....*....|....*....|....*..
gi 2183974163 2032 RDtLRQALKASLPEHMVPAHLLFLERLPLTANGKLDR 2068
Cdd:cd17635    305 RA-LKHTIRRELEPYARPSTIVIVTDIPRTQSGKVKR 340

PRK12583

acyl-CoA synthetase; Provisional

1569-2068

4.89e-28

acyl-CoA synthetase; Provisional

Pssm-ID: 237145 [Multi-domain] Cd Length: 558 Bit Score: 122.19 E-value: 4.89e-28

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1569 CLHRLIERQAAERPRATAVVYGERAL--DYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYV 1646
Cdd:PRK12583    19 TIGDAFDATVARFPDREALVVRHQALryTWRQLADAVDRLARGLLALGVQPGDRVGIWAPNCAEWLLTQFATARIGAILV 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1647 PLDPRYPSDRLGYMIEDSGIRLLLTQRAAR-------------------------ERLPLGEGLpcLLLDAE-------- 1693
Cdd:PRK12583    99 NINPAYRASELEYALGQSGVRWVICADAFKtsdyhamlqellpglaegqpgalacERLPELRGV--VSLAPApppgflaw 176

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1694 HEWAGYPES-------DPQSAVGVDNLAYVIYTSGSTGKPKGTLLPHGNVLR--LFDATRhwFGFSADDAW----SLFHS 1760
Cdd:PRK12583   177 HELQARGETvsrealaERQASLDRDDPINIQYTSGTTGFPKGATLSHHNILNngYFVAES--LGLTEHDRLcvpvPLYHC 254

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1761 YAFdfsVWEIFGALLHGGRLVIvPYEtSRSPEDFLRLLCRERVTVLNQTPSAF--------------KQLMQVACAGQEV 1826
Cdd:PRK12583   255 FGM---VLANLGCMTVGACLVY-PNE-AFDPLATLQAVEEERCTALYGVPTMFiaeldhpqrgnfdlSSLRTGIMAGAPC 329

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1827 PPLALRHVVFGGEALEVQAlrpwferfgdraprlvnMYGITETTvHVTYRPLSLADLDGGAASpIGEPIPDLSWYLLDAG 1906
Cdd:PRK12583   330 PIEVMRRVMDEMHMAEVQI-----------------AYGMTETS-PVSLQTTAADDLERRVET-VGRTQPHLEVKVVDPD 390

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1907 LNPVPRGCIGELYVGGAGLARGYLNRPELSCTRFVADpfsttgGRLYrTGDLARYRCDGVVEYVGRIDHQVKIRGFRIEL 1986
Cdd:PRK12583   391 GATVPRGEIGELCTRGYSVMKGYWNNPEATAESIDED------GWMH-TGDLATMDEQGYVRIVGRSKDMIIRGGENIYP 463

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1987 GEIEARLLAQPGVAEAVV--LPHEGPGaTQLVGYVVTQaapSDPAALRDTLRQALKASLPEHMVPAHLLFLERLPLTANG 2064
Cdd:PRK12583   464 REIEEFLFTHPAVADVQVfgVPDEKYG-EEIVAWVRLH---PGHAASEEELREFCKARIAHFKVPRYFRFVDEFPMTVTG 539


                   ....
gi 2183974163 2065 KLDR 2068
Cdd:PRK12583   540 KVQK 543

A_NRPS_ProA

cd17656

gramicidin S synthase 2, also known as ATP-dependent proline adenylase; This family of the ...

3098-3183

5.12e-28

Pssm-ID: 341311 [Multi-domain] Cd Length: 479 Bit Score: 121.04 E-value: 5.12e-28

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3098 TPTAPALAFGEERLDYAELNRRANRLAHALIERGIGADRLVGVAMERSIEMVVALMAILKAGGAYVPVDPEYPEERQAYM 3177
Cdd:cd17656      1 TPDAVAVVFENQKLTYRELNERSNQLARFLREKGVKKDSIVAIMMERSAEMIVGILGILKAGGAFVPIDPEYPEERRIYI 80


                   ....*.
gi 2183974163 3178 LEDSGV 3183
Cdd:cd17656     81 MLDSGV 86

PRK06178

acyl-CoA synthetase; Validated

1578-2071

5.75e-28

acyl-CoA synthetase; Validated

Pssm-ID: 235724 [Multi-domain] Cd Length: 567 Bit Score: 122.07 E-value: 5.75e-28

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1578 AAERPRATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRL 1657
Cdd:PRK06178    43 ARERPQRPAIIFYGHVITYAELDELSDRFAALLRQRGVGAGDRVAVFLPNCPQFHIVFFGILKLGAVHVPVSPLFREHEL 122

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1658 GYMIEDSGIRLLLTQ-------RAARERLPLGEG----------------LPCLLLDAEHEWAGY----------PESDP 1704
Cdd:PRK06178   123 SYELNDAGAEVLLALdqlapvvEQVRAETSLRHVivtsladvlpaeptlpLPDSLRAPRLAAAGAidllpalracTAPVP 202

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1705 QSAVGVDNLAYVIYTSGSTGKPKGTLLPHGNVLRLFdATRHWFGFSADDAwSLFHSYAFDFsvW---EIFGALL---HGG 1778
Cdd:PRK06178   203 LPPPALDALAALNYTGGTTGMPKGCEHTQRDMVYTA-AAAYAVAVVGGED-SVFLSFLPEF--WiagENFGLLFplfSGA 278

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1779 RLVIVpyeTSRSPEDFLRLLCRERVTVLNQTPSAFKQLMqvacagqEVPPLA------LRHVvfgGEALEVQALRPWF-E 1851
Cdd:PRK06178   279 TLVLL---ARWDAVAFMAAVERYRVTRTVMLVDNAVELM-------DHPRFAeydlssLRQV---RVVSFVKKLNPDYrQ 345

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1852 RFGDRAPRLV--NMYGITETTVHVTY-RPLSLADLD-GGAASPIGEPIPDLSWYLLD--AGlNPVPRGCIGELYVGGAGL 1925
Cdd:PRK06178   346 RWRALTGSVLaeAAWGMTETHTCDTFtAGFQDDDFDlLSQPVFVGLPVPGTEFKICDfeTG-ELLPLGAEGEIVVRTPSL 424

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1926 ARGYLNRPELSCTRFVadpfsttGGRLyRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVVL 2005
Cdd:PRK06178   425 LKGYWNKPEATAEALR-------DGWL-HTGDIGKIDEQGFLHYLGRRKEMLKVNGMSVFPSEVEALLGQHPAVLGSAVV 496

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2183974163 2006 PHEGPGATQL-VGYVVTQ-AAPSDPAALRDTLRQALKAslpeHMVPaHLLFLERLPLTANGKLDRRAL 2071
Cdd:PRK06178   497 GRPDPDKGQVpVAFVQLKpGADLTAAALQAWCRENMAV----YKVP-EIRIVDALPMTATGKVRKQDL 559

PRK07786

long-chain-fatty-acid--CoA ligase; Validated

520-1024

6.60e-28

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 169098 [Multi-domain] Cd Length: 542 Bit Score: 121.81 E-value: 6.60e-28

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  520 AGLTPDAPALLFGEERLSYAELNALANRLAWRLREEGVG-SDVLVGIALERgVPMVVALLAVLKAGGAYVPLDPQYPADR 598
Cdd:PRK07786    27 ALMQPDAPALRFLGNTTTWRELDDRVAALAGALSRRGVGfGDRVLILMLNR-TEFVESVLAANMLGAIAVPVNFRLTPPE 105

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  599 LQYMIDDSGLRLLLSQ---QSVLARLPQSDGLQSLLL---DDLERLVHGY--------PAENP-DLPEapDSLCYAIYTS 663
Cdd:PRK07786   106 IAFLVSDCGAHVVVTEaalAPVATAVRDIVPLLSTVVvagGSSDDSVLGYedllaeagPAHAPvDIPN--DSPALIMYTS 183

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  664 GSTGQPKGVMVRHRALTNFVCSIARQPGMLARDRLLSVTTFSFDIFGLELYVP-LARGASMLLASReQAQDPEALLDLVE 742
Cdd:PRK07786   184 GTTGRPKGAVLTHANLTGQAMTCLRTNGADINSDVGFVGVPLFHIAGIGSMLPgLLLGAPTVIYPL-GAFDPGQLLDVLE 262

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  743 RQGVTVLQATPATWRMLCDSERV---DL-LRgctLLCGGEALAED-LAARMRGLSASTWNL--YGPTETTIWSARFrLGE 815
Cdd:PRK07786   263 AEKVTGIFLVPAQWQAVCAEQQArprDLaLR---VLSWGAAPASDtLLRQMAATFPEAQILaaFGQTEMSPVTCML-LGE 338

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  816 EA---RPFLGGPLENTALYILDSEMNPCPPGVAGELLIGGDGLARGYHRRPGLTAERFlpdpfaADGsrLYRTGDLARYR 892
Cdd:PRK07786   339 DAirkLGSVGKVIPTVAARVVDENMNDVPVGEVGEIVYRAPTLMSGYWNNPEATAEAF------AGG--WFHSGDLVRQD 410

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  893 ADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQPGVA-GPTLVAYLVPTEaalvDAESARQQELRSAL 971
Cdd:PRK07786   411 EEGYVWVVDRKKDMIISGGENIYCAEVENVLASHPDIVEVAVIGRADEKwGEVPVAVAAVRN----DDAALTLEDLAEFL 486

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2183974163  972 KNSllavLPDYMVPAHMLLLENLPLTPNGKIN----RKALPLPDASAVRDAHVAPEG 1024
Cdd:PRK07786   487 TDR----LARYKHPKALEIVDALPRNPAGKVLktelRERYGACVNVERRSASAGFTE 539

PRK06155

crotonobetaine/carnitine-CoA ligase; Provisional

491-1007

7.00e-28

crotonobetaine/carnitine-CoA ligase; Provisional

Pssm-ID: 235719 [Multi-domain] Cd Length: 542 Bit Score: 121.40 E-value: 7.00e-28

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  491 ERATLLQRSRLPASEYPAGQGVHRLFEAQAGLTPDAPALLFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERG 570
Cdd:PRK06155     2 EPLGAGLAARAVDPLPPSERTLPAMLARQAERYPDRPLLVFGGTRWTYAEAARAAAAAAHALAAAGVKRGDRVALMCGNR 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  571 VPMVVALLAVLKAGGAYVPLDPQYPADRLQYMIDDSGLRLLLSQQSVLARlpqsdgLQSLLLDDLER----LVHGYPAEN 646
Cdd:PRK06155    82 IEFLDVFLGCAWLGAIAVPINTALRGPQLEHILRNSGARLLVVEAALLAA------LEAADPGDLPLpavwLLDAPASVS 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  647 PD-------LPEAPDSLCYA----------IYTSGSTGQPKGVMVRHRALTNFVCSIARQPGMLARDRLLsvTTFS-FDI 708
Cdd:PRK06155   156 VPagwstapLPPLDAPAPAAavqpgdtaaiLYTSGTTGPSKGVCCPHAQFYWWGRNSAEDLEIGADDVLY--TTLPlFHT 233

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  709 FGLELYVP-LARGASMLLASREQAQdpeALLDLVERQGVTV----------LQATPATwrmlcDSERVDLLRGCTLLCGG 777
Cdd:PRK06155   234 NALNAFFQaLLAGATYVLEPRFSAS---GFWPAVRRHGATVtyllgamvsiLLSQPAR-----ESDRAHRVRVALGPGVP 305

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  778 EALAEDLAAR--MRGLSAstwnlYGPTETTI------------WSARFRLGEEARpflggplentalyILDSEMNPCPPG 843
Cdd:PRK06155   306 AALHAAFRERfgVDLLDG-----YGSTETNFviavthgsqrpgSMGRLAPGFEAR-------------VVDEHDQELPDG 367

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  844 VAGELLIGGD---GLARGYHRRPGLTAErflpdpfaADGSRLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIE 920
Cdd:PRK06155   368 EPGELLLRADepfAFATGYFGMPEKTVE--------AWRNLWFHTGDRVVRDADGWFRFVDRIKDAIRRRGENISSFEVE 439

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  921 TRLLEQDSVREAVVVAQPG-VAGPTLVAYLVPTEA-ALVDAESARQQELRsalknsllavLPDYMVPAHMLLLENLPLTP 998
Cdd:PRK06155   440 QVLLSHPAVAAAAVFPVPSeLGEDEVMAAVVLRDGtALEPVALVRHCEPR----------LAYFAVPRYVEFVAALPKTE 509


                   ....*....
gi 2183974163  999 NGKINRKAL 1007
Cdd:PRK06155   510 NGKVQKFVL 518

MACS_AAE_MA_like

cd05970

Medium-chain acyl-CoA synthetase (MACS) of AAE_MA like; MACS catalyzes the two-step activation ...

1561-2068

1.23e-27

Pssm-ID: 341274 [Multi-domain] Cd Length: 537 Bit Score: 120.68 E-value: 1.23e-27

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1561 PQDFTPAsclHRLIERQAAERPRATAVVY-----GERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGL 1635
Cdd:cd05970     13 PENFNFA---YDVVDAMAKEYPDKLALVWcddagEERIFTFAELADYSDKTANFFKAMGIGKGDTVMLTLKRRYEFWYSL 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1636 LAILKAGGAYVPLDPRYPSDRLGYMIEDSGIRLL-------LTQR--AARERLP-------LGEGLPCLLLDAEHEWAGY 1699
Cdd:cd05970     90 LALHKLGAIAIPATHQLTAKDIVYRIESADIKMIvaiaednIPEEieKAAPECPskpklvwVGDPVPEGWIDFRKLIKNA 169

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1700 PES-----DPQSAVGvDNLAYVIYTSGSTGKPKGT----LLPHGNVL------RLFDATRHWFgfSADDAWSLfhsyafd 1764
Cdd:cd05970    170 SPDferptANSYPCG-EDILLVYFSSGTTGMPKMVehdfTYPLGHIVtakywqNVREGGLHLT--VADTGWGK------- 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1765 fSVW-EIFGALLHGGRLVIVPYETSrSPEDFLRLLCRERVTVLNQTPSAFKQLMQVACAGQEVPplALRHVVFGGEALEV 1843
Cdd:cd05970    240 -AVWgKIYGQWIAGAAVFVYDYDKF-DPKALLEKLSKYGVTTFCAPPTIYRFLIREDLSRYDLS--SLRYCTTAGEALNP 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1844 QALRPWFERFGdraPRLVNMYGITETTvhvtyrpLSLADLDGGAASP--IGEPIPDLSWYLLDAGLNPVPRGCIGELYVG 1921
Cdd:cd05970    316 EVFNTFKEKTG---IKLMEGFGQTETT-------LTIATFPWMEPKPgsMGKPAPGYEIDLIDREGRSCEAGEEGEIVIR 385

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1922 GA-----GLARGYLNRPELSCtrfvadpfSTTGGRLYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQ 1996
Cdd:cd05970    386 TSkgkpvGLFGGYYKDAEKTA--------EVWHDGYYHTGDAAWMDEDGYLWFVGRTDDLIKSSGYRIGPFEVESALIQH 457

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2183974163 1997 PGVAEAVVLPHEGPGATQLVGYVVTQAAPSDPA-ALRDTLRQALKASLPEHMVPAHLLFLERLPLTANGKLDR 2068
Cdd:cd05970    458 PAVLECAVTGVPDPIRGQVVKATIVLAKGYEPSeELKKELQDHVKKVTAPYKYPRIVEFVDELPKTISGKIRR 530

PRK13295

cyclohexanecarboxylate-CoA ligase; Reviewed

1578-2071

2.47e-27

cyclohexanecarboxylate-CoA ligase; Reviewed

Pssm-ID: 171961 [Multi-domain] Cd Length: 547 Bit Score: 119.77 E-value: 2.47e-27

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1578 AAERPRATAVV-----YGE-RALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPR 1651
Cdd:PRK13295    34 VASCPDKTAVTavrlgTGApRRFTYRELAALVDRVAVGLARLGVGRGDVVSCQLPNWWEFTVLYLACSRIGAVLNPLMPI 113

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1652 YPSDRLGYMIEDSGIRLLLTQRAAR--ERLPLGEGLPCLLLDAEH-------------------EWAGYPESDP---QSA 1707
Cdd:PRK13295   114 FRERELSFMLKHAESKVLVVPKTFRgfDHAAMARRLRPELPALRHvvvvggdgadsfeallitpAWEQEPDAPAilaRLR 193

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1708 VGVDNLAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRHWFGFSADD----AWSLFHSYAFdfsvweIFGALLH---GGRL 1780
Cdd:PRK13295   194 PGPDDVTQLIYTSGTTGEPKGVMHTANTLMANIVPYAERLGLGADDvilmASPMAHQTGF------MYGLMMPvmlGATA 267

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1781 VivpYETSRSPEDFLRLLCRERVT--------------VLNQTPSAFKQLMQVACAGQEVPPlalrhvvfggeALEVQAL 1846
Cdd:PRK13295   268 V---LQDIWDPARAAELIRTEGVTftmastpfltdltrAVKESGRPVSSLRTFLCAGAPIPG-----------ALVERAR 333

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1847 rpwfERFGdraPRLVNMYGITETTVHVTYRPlslADLDGGAASPIGEPIPDLSWYLLDAGLNPVPRGCIGELYVGGAGLA 1926
Cdd:PRK13295   334 ----AALG---AKIVSAWGMTENGAVTLTKL---DDPDERASTTDGCPLPGVEVRVVDADGAPLPAGQIGRLQVRGCSNF 403

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1927 RGYLNRPELscTRFVADPFsttggrlYRTGDLARYRCDGVVEYVGRiDHQVKIRGFR-IELGEIEARLLAQPGVAEAVVL 2005
Cdd:PRK13295   404 GGYLKRPQL--NGTDADGW-------FDTGDLARIDADGYIRISGR-SKDVIIRGGEnIPVVEIEALLYRHPAIAQVAIV 473

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2183974163 2006 --PHEGPGaTQLVGYVVTQAAPS-DPAALRDTLRQalkASLPEHMVPAHLLFLERLPLTANGKLDRRAL 2071
Cdd:PRK13295   474 ayPDERLG-ERACAFVVPRPGQSlDFEEMVEFLKA---QKVAKQYIPERLVVRDALPRTPSGKIQKFRL 538

A_NRPS_Ta1_like

cd12116

The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A ...

3099-3183

3.72e-27

Pssm-ID: 341281 [Multi-domain] Cd Length: 470 Bit Score: 118.16 E-value: 3.72e-27

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3099 PTAPALAFGEERLDYAELNRRANRLAHALIERGIGADRLVGVAMERSIEMVVALMAILKAGGAYVPVDPEYPEERQAYML 3178
Cdd:cd12116      1 PDATAVRDDDRSLSYAELDERANRLAARLRARGVGPGDRVAVYLPRSARLVAAMLAVLKAGAAYVPLDPDYPADRLRYIL 80


                   ....*
gi 2183974163 3179 EDSGV 3183
Cdd:cd12116     81 EDAEP 85

PRK08279

long-chain-acyl-CoA synthetase; Validated

470-985

4.49e-27

long-chain-acyl-CoA synthetase; Validated

Pssm-ID: 236217 [Multi-domain] Cd Length: 600 Bit Score: 119.59 E-value: 4.49e-27

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  470 LEAVVAEPRRRLGDLPLLDaeeRATLLQRSRLPASEYpagqGVHRLFEAQAGLTPDAPALLFGEERLSYAELNALANRLA 549
Cdd:PRK08279     4 LMDLAARLPRRLPDLPGIL---RGLKRTALITPDSKR----SLGDVFEEAAARHPDRPALLFEDQSISYAELNARANRYA 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  550 WRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQYMIDDSGLRLL----------------LS 613
Cdd:PRK08279    77 HWAAARGVGKGDVVALLMENRPEYLAAWLGLAKLGAVVALLNTQQRGAVLAHSLNLVDAKHLivgeelveafeearadLA 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  614 QQSVLARLPQSDGLQSLLLDDLERLVHGYPAENPDLPEA--PDSLCYAIYTSGSTGQPKGVMVRHRALTNFVCSIARQPG 691
Cdd:PRK08279   157 RPPRLWVAGGDTLDDPEGYEDLAAAAAGAPTTNPASRSGvtAKDTAFYIYTSGTTGLPKAAVMSHMRWLKAMGGFGGLLR 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  692 MLARDRLLSVttfsfdifgLELY----------VPLARGASMLLASREQAQdpeALLDLVERQGVTVLQATPATWRMLCD 761
Cdd:PRK08279   237 LTPDDVLYCC---------LPLYhntggtvawsSVLAAGATLALRRKFSAS---RFWDDVRRYRATAFQYIGELCRYLLN 304

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  762 SERVDLLRG--CTLLCGGealaedlaarmrGLSASTWN-------------LYGPTETTIW---------SARFRLGEEA 817
Cdd:PRK08279   305 QPPKPTDRDhrLRLMIGN------------GLRPDIWDefqqrfgiprileFYAASEGNVGfinvfnfdgTVGRVPLWLA 372

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  818 RPF--------LGGPLENTalyilDSEMNPCPPGVAGELL--IGGDGLARGYhRRPGLTAERFLPDPFaADGSRLYRTGD 887
Cdd:PRK08279   373 HPYaivkydvdTGEPVRDA-----DGRCIKVKPGEVGLLIgrITDRGPFDGY-TDPEASEKKILRDVF-KKGDAWFNTGD 445

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  888 LARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVV--VAQPGVAGPTLVAYLVPTEAALVDaesarqq 965
Cdd:PRK08279   446 LMRDDGFGHAQFVDRLGDTFRWKGENVATTEVENALSGFPGVEEAVVygVEVPGTDGRAGMAAIVLADGAEFD------- 518

                          570       580
                   ....*....|....*....|
gi 2183974163  966 elRSALKNSLLAVLPDYMVP 985
Cdd:PRK08279   519 --LAALAAHLYERLPAYAVP 536

LC_FACS_like

cd17640

Long-chain fatty acid CoA synthetase; This family includes long-chain fatty acid (C12-C20) CoA ...

532-937

5.04e-27

Long-chain fatty acid CoA synthetase; This family includes long-chain fatty acid (C12-C20) CoA synthetases, including an Arabidopsis gene At4g14070 that plays a role in activation and elongation of exogenous fatty acids. FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Eukaryotes generally have multiple isoforms of LC-FACS genes with multiple splice variants. For example, nine genes are found in Arabidopsis and six genes are expressed in mammalian cells. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.

Pssm-ID: 341295 [Multi-domain] Cd Length: 468 Bit Score: 117.85 E-value: 5.04e-27

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  532 GEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQYMIDDSGLRLL 611
Cdd:cd17640      2 PPKRITYKDLYQEILDFAAGLRSLGVKAGEKVALFADNSPRWLIADQGIMALGAVDVVRGSDSSVEELLYILNHSESVAL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  612 LsqqsvlarlpqsdglqslllddlerlvhgypAENpdlpeAPDSLCYAIYTSGSTGQPKGVMVRHRALT----NFVCSIA 687
Cdd:cd17640     82 V-------------------------------VEN-----DSDDLATIIYTSGTTGNPKGVMLTHANLLhqirSLSDIVP 125

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  688 RQPGmlarDRLLSVTTfSFDIF--GLElYVPLARGASMLLASreqaqdPEALLDLVERQGVTVLQATPATWRMLcdSERV 765
Cdd:cd17640    126 PQPG----DRFLSILP-IWHSYerSAE-YFIFACGCSQAYTS------IRTLKDDLKRVKPHYIVSVPRLWESL--YSGI 191

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  766 D----------------LLRGCTL---LCGGEALAEDLAARMRGLSASTWNLYGPTETTIWSARFRLGEEARPFLGGPLE 826
Cdd:cd17640    192 QkqvsksspikqflflfFLSGGIFkfgISGGGALPPHVDTFFEAIGIEVLNGYGLTETSPVVSARRLKCNVRGSVGRPLP 271

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  827 NTALYILDSEMN-PCPPGVAGELLIGGDGLARGYHRRPGLTAERFLPDPFaadgsrlYRTGDLARYRADGVIEYLGRI-D 904
Cdd:cd17640    272 GTEIKIVDPEGNvVLPPGEKGIVWVRGPQVMKGYYKNPEATSKVLDSDGW-------FNTGDLGWLTCGGELVLTGRAkD 344

                          410       420       430
                   ....*....|....*....|....*....|...
gi 2183974163  905 HQVKIRGFRIELGEIETRLLEQDSVREAVVVAQ 937
Cdd:cd17640    345 TIVLSNGENVEPQPIEEALMRSPFIEQIMVVGQ 377

PRK07529

AMP-binding domain protein; Validated

487-1032

5.60e-27

AMP-binding domain protein; Validated

Pssm-ID: 236043 [Multi-domain] Cd Length: 632 Bit Score: 119.67 E-value: 5.60e-27

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  487 LDAEERATLLQRsRLPASEYpagqgvhRLFEAQAGLTPDAPAL---LFGE-----ERLSYAELNALANRLAWRLREEGVG 558
Cdd:PRK07529    10 IEAIEAVPLAAR-DLPASTY-------ELLSRAAARHPDAPALsflLDADpldrpETWTYAELLADVTRTANLLHSLGVG 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  559 SDVLVGIALERGVPMVVALLAVLKAGGAyVPLDPQYPADRLQYMIDDSGLRLLL------------SQQSVLARLPqsdG 626
Cdd:PRK07529    82 PGDVVAFLLPNLPETHFALWGGEAAGIA-NPINPLLEPEQIAELLRAAGAKVLVtlgpfpgtdiwqKVAEVLAALP---E 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  627 LQSLLLDDLERL-------------------VHGYPAE----------NPDLPEAPDSLCYaIYTSGSTGQPKGVMVRHR 677
Cdd:PRK07529   158 LRTVVEVDLARYlpgpkrlavplirrkaharILDFDAElarqpgdrlfSGRPIGPDDVAAY-FHTGGTTGMPKLAQHTHG 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  678 ALTNFVCSIARQPGMLARDRLLSVTTFsFDIFGL--ELYVPLARGASMLLASREQAQDPEA---LLDLVERQGVTVLQAT 752
Cdd:PRK07529   237 NEVANAWLGALLLGLGPGDTVFCGLPL-FHVNALlvTGLAPLARGAHVVLATPQGYRGPGVianFWKIVERYRINFLSGV 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  753 PATWRML----CDSERVDLLRgcTLLCGGEALAEDLAAR-MRGLSASTWNLYGPTETTIWSAR-FRLGEEARPFLGGPLE 826
Cdd:PRK07529   316 PTVYAALlqvpVDGHDISSLR--YALCGAAPLPVEVFRRfEAATGVRIVEGYGLTEATCVSSVnPPDGERRIGSVGLRLP 393

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  827 NTALYILDSEMN-----PCPPGVAGELLIGGDGLARGYhrrpgLTAERflpDPFAADGSRLYRTGDLARYRADGVIEYLG 901
Cdd:PRK07529   394 YQRVRVVILDDAgrylrDCAVDEVGVLCIAGPNVFSGY-----LEAAH---NKGLWLEDGWLNTGDLGRIDADGYFWLTG 465

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  902 RidhqVK---IR-GFRIELGEIETRLLEQDSVREAVVVAQPGV-AGPTLVAY--LVP----TEAALVDAESARQQElRSA 970
Cdd:PRK07529   466 R----AKdliIRgGHNIDPAAIEEALLRHPAVALAAAVGRPDAhAGELPVAYvqLKPgasaTEAELLAFARDHIAE-RAA 540

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  971 lknsllavlpdymVPAHMLLLENLPLTPNGKIN-------------RKAL-----PLPDASAVRD------AHVAPEGEL 1026
Cdd:PRK07529   541 -------------VPKHVRILDALPKTAVGKIFkpalrrdairrvlRAALrdagvEAEVVDVVEDgrrglvAQVALRGAE 607


                   ....*.
gi 2183974163 1027 ERAMAA 1032
Cdd:PRK07529   608 DREAVA 613

PrpE

cd05967

Propionyl-CoA synthetase (PrpE); EC 6.2.1.17: propanoate:CoA ligase (AMP-forming) or ...

1574-2086

5.85e-27

Propionyl-CoA synthetase (PrpE); EC 6.2.1.17: propanoate:CoA ligase (AMP-forming) or propionate#CoA ligase (PrpE) catalyzes the first step of the 2-methylcitric acid cycle for propionate catabolism. It activates propionate to propionyl-CoA in a two-step reaction, which proceeds through a propionyl-AMP intermediate and requires ATP and Mg2+. In Salmonella enterica, the PrpE protein is required for growth of Salmonella enterica on propionate and can substitute for the acetyl-CoA synthetase (Acs) enzyme during growth on acetate. PrpE can also activate acetate, 3HP, and butyrate to their corresponding CoA-thioesters, although with less efficiency.

Pssm-ID: 341271 [Multi-domain] Cd Length: 617 Bit Score: 119.34 E-value: 5.85e-27

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1574 IERQAAE-RPRATAVVY------GERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYV 1646
Cdd:cd05967     56 LDRHVEAgRGDQIALIYdspvtgTERTYTYAELLDEVSRLAGVLRKLGVVKGDRVIIYMPMIPEAAIAMLACARIGAIHS 135

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1647 PLDPRYPSDRLGYMIEDSGIRLLLTQRAA-------------------------------RERLPLGEGLPCLLLDAEHE 1695
Cdd:cd05967    136 VVFGGFAAKELASRIDDAKPKLIVTASCGiepgkvvpykplldkalelsghkphhvlvlnRPQVPADLTKPGRDLDWSEL 215

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1696 WAGYPESDPQSAVGVDNLaYVIYTSGSTGKPKGTLLPH-GNVLRLFDATRHWFG-------FSADD-AWSLFHSYAfdfs 1766
Cdd:cd05967    216 LAKAEPVDCVPVAATDPL-YILYTSGTTGKPKGVVRDNgGHAVALNWSMRNIYGikpgdvwWAASDvGWVVGHSYI---- 290

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1767 vweIFGALLHG-------GRLVIVPyetsrSPEDFLRLLCRERVTVLNQTPSAFKQLMQV---ACAGQEVPPLALRHVVF 1836
Cdd:cd05967    291 ---VYGPLLHGattvlyeGKPVGTP-----DPGAFWRVIEKYQVNALFTAPTAIRAIRKEdpdGKYIKKYDLSSLRTLFL 362

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1837 GGEALEVQALRpWFERFGDRAprLVNMYGITETTVHVTYRPLSLADLDGGAASPiGEPIPDLSWYLLDAGLNPVPRGCIG 1916
Cdd:cd05967    363 AGERLDPPTLE-WAENTLGVP--VIDHWWQTETGWPITANPVGLEPLPIKAGSP-GKPVPGYQVQVLDEDGEPVGPNELG 438

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1917 ELYVGGA---GLARGYLNRPElsctRFVADPFSTTGGrLYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARL 1993
Cdd:cd05967    439 NIVIKLPlppGCLLTLWKNDE----RFKKLYLSKFPG-YYDTGDAGYKDEDGYLFIMGRTDDVINVAGHRLSTGEMEESV 513

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1994 LAQPGVAEAVVL--PHEGPGATQLVGYVVTQAAPSDPAALRDTLRQALKASLPEHMVPAHLLFLERLPLTANGKLDRRAL 2071
Cdd:cd05967    514 LSHPAVAECAVVgvRDELKGQVPLGLVVLKEGVKITAEELEKELVALVREQIGPVAAFRLVIFVKRLPKTRSGKILRRTL 593

                          570
                   ....*....|....*.
gi 2183974163 2072 PA-PDasrlQRDYTAP 2086
Cdd:cd05967    594 RKiAD----GEDYTIP 605

PRK05857

fatty acid--CoA ligase;

1566-2073

5.92e-27

fatty acid--CoA ligase;

Pssm-ID: 180293 [Multi-domain] Cd Length: 540 Bit Score: 118.57 E-value: 5.92e-27

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1566 PASCLHRLIErQAAERPRATAVVY--GERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGG 1643
Cdd:PRK05857    13 PSTVLDRVFE-QARQQPEAIALRRcdGTSALRYRELVAEVGGLAADLRAQSVSRGSRVLVISDNGPETYLSVLACAKLGA 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1644 AYVPLDPRYPS---DRLGYMIEDSGIRLLLTQRAARERLPLG-EGLPCLLLDAEHEWA--------GYPESDPQSavGVD 1711
Cdd:PRK05857    92 IAVMADGNLPIaaiERFCQITDPAAALVAPGSKMASSAVPEAlHSIPVIAVDIAAVTResehsldaASLAGNADQ--GSE 169

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1712 NLAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRH----WFGFSADDAWSLFHSYAFDFSVWEIFGALLHGGrLVIVPYET 1787
Cdd:PRK05857   170 DPLAMIFTSGTTGEPKAVLLANRTFFAVPDILQKeglnWVTWVVGETTYSPLPATHIGGLWWILTCLMHGG-LCVTGGEN 248

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1788 SRSpedFLRLLCRERVTVLNQTPSAFKQLM-QVACAGQEVPPlaLRHVVFGGEALEVQALRpWFERFGDRAPRLvnmYGI 1866
Cdd:PRK05857   249 TTS---LLEILTTNAVATTCLVPTLLSKLVsELKSANATVPS--LRLVGYGGSRAIAADVR-FIEATGVRTAQV---YGL 319

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1867 TETTVHVTYRPL---SLADLDGGAaspIGEPIPDLSWYLLDA-GLNPV-----PRGCIGELYVGGAGLARGYLNRPELSc 1937
Cdd:PRK05857   320 SETGCTALCLPTddgSIVKIEAGA---VGRPYPGVDVYLAATdGIGPTapgagPSASFGTLWIKSPANMLGYWNNPERT- 395

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1938 TRFVADPFsttggrlYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVV--LPHEGPGAtqL 2015
Cdd:PRK05857   396 AEVLIDGW-------VNTGDLLERREDGFFYIKGRSSEMIICGGVNIAPDEVDRIAEGVSGVREAACyeIPDEEFGA--L 466

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2183974163 2016 VGYVVTQAAPSDPAALRDtLRQALKASL---PEHMV-PAHLLFLERLPLTANGKLDRRALPA 2073
Cdd:PRK05857   467 VGLAVVASAELDESAARA-LKHTIAARFrreSEPMArPSTIVIVTDIPRTQSGKVMRASLAA 527

AACS_like

cd05968

Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; This ...

512-1017

6.17e-27

Pssm-ID: 341272 [Multi-domain] Cd Length: 610 Bit Score: 119.52 E-value: 6.17e-27

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  512 VHRLFEAQAGLTPDAPALLFGEER-----LSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGA 586
Cdd:cd05968     63 VEQLLDKWLADTRTRPALRWEGEDgtsrtLTYGELLYEVKRLANGLRALGVGKGDRVGIYLPMIPEIVPAFLAVARIGGI 142

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  587 YVPLDPQYPADRLQYMIDDSGLRLLLSQQSVLARlpqsdGLQSLLLDDLERLVHGYP----------AENPDLPEAPDSL 656
Cdd:cd05968    143 VVPIFSGFGKEAAATRLQDAEAKALITADGFTRR-----GREVNLKEEADKACAQCPtvekvvvvrhLGNDFTPAKGRDL 217

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  657 CYA---------------------IYTSGSTGQPKGVMVRHRAL-TNFVCSIARQPGMLARDRLLSVTTFSFDIFGLELY 714
Cdd:cd05968    218 SYDeeketagdgaertesedplmiIYTSGTTGKPKGTVHVHAGFpLKAAQDMYFQFDLKPGDLLTWFTDLGWMMGPWLIF 297

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  715 VPLARGASMLLasREQAQD---PEALLDLVERQGVTVLQATPATWRmlcdservdllrgcTLLCGGEAL--AEDLAA-RM 788
Cdd:cd05968    298 GGLILGATMVL--YDGAPDhpkADRLWRMVEDHEITHLGLSPTLIR--------------ALKPRGDAPvnAHDLSSlRV 361

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  789 RGLSASTWNLygptETTIWSARFRLGEEA---------------------RPF----LGGPLENTALYILDSEMNPCPPG 843
Cdd:cd05968    362 LGSTGEPWNP----EPWNWLFETVGKGRNpiinysggteisggilgnvliKPIkpssFNGPVPGMKADVLDESGKPARPE 437

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  844 VaGELLIGGD--GLARGYHRRPgltaERFLPDPFaadgSRL---YRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGE 918
Cdd:cd05968    438 V-GELVLLAPwpGMTRGFWRDE----DRYLETYW----SRFdnvWVHGDFAYYDEEGYFYILGRSDDTINVAGKRVGPAE 508

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  919 IETRLLEQDSVREAVVVAQPG-VAGPTLVAYLVPTEAalVDAESARQQELRSALKNSLLAVLpdymVPAHMLLLENLPLT 997
Cdd:cd05968    509 IESVLNAHPAVLESAAIGVPHpVKGEAIVCFVVLKPG--VTPTEALAEELMERVADELGKPL----SPERILFVKDLPKT 582

                          570       580
                   ....*....|....*....|....*..
gi 2183974163  998 PNGKINRKAL-------PLPDASAVRD 1017
Cdd:cd05968    583 RNAKVMRRVIraaylgkELGDLSSLEN 609

PRK08751

long-chain fatty acid--CoA ligase;

1698-2071

6.85e-27

long-chain fatty acid--CoA ligase;

Pssm-ID: 181546 [Multi-domain] Cd Length: 560 Bit Score: 118.83 E-value: 6.85e-27

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1698 GYPESDPQSAVGVDNLAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRHWFGFSAD---------DAWSLFHSYAFDFS-- 1766
Cdd:PRK08751   195 GRKHSMPTLQIEPDDIAFLQYTGGTTGVAKGAMLTHRNLVANMQQAHQWLAGTGKleegcevviTALPLYHIFALTANgl 274

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1767 VWEIFGALLHggrLVIVPyetsRSPEDFLRLLCRERVTVLNQTPSAFKQLMQVACAGQeVPPLALRHVVFGGEALEVQAL 1846
Cdd:PRK08751   275 VFMKIGGCNH---LISNP----RDMPGFVKELKKTRFTAFTGVNTLFNGLLNTPGFDQ-IDFSSLKMTLGGGMAVQRSVA 346

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1847 RPWFERFGdraPRLVNMYGITETTVHVTYRPLSLADLDGGaaspIGEPIPDLSWYLLDAGLNPVPRGCIGELYVGGAGLA 1926
Cdd:PRK08751   347 ERWKQVTG---LTLVEAYGLTETSPAACINPLTLKEYNGS----IGLPIPSTDACIKDDAGTVLAIGEIGELCIKGPQVM 419

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1927 RGYLNRPELSCTRFVADPFsttggrlYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAE--AVV 2004
Cdd:PRK08751   420 KGYWKRPEETAKVMDADGW-------LHTGDIARMDEQGFVYIVDRKKDMILVSGFNVYPNEIEDVIAMMPGVLEvaAVG 492

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2183974163 2005 LPHEGPGatQLVGYVVTQaapSDPAALRDTLRQALKASLPEHMVPAHLLFLERLPLTANGKLDRRAL 2071
Cdd:PRK08751   493 VPDEKSG--EIVKVVIVK---KDPALTAEDVKAHARANLTGYKQPRIIEFRKELPKTNVGKILRREL 554

LCL_NRPS-like

LCL-type Condensation (C) domain of non-ribosomal peptide synthetases(NRPSs) and similar ...

2204-2431

7.31e-27

Pssm-ID: 380454 [Multi-domain] Cd Length: 427 Bit Score: 116.69 E-value: 7.31e-27

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2204 ALDGTLLETALQALLAHHDALRLGFRLEDGTWR---AEHRAVEAGEVLL--WQQSVADGQALEALAEQVQRSLDLGSGPL 2278
Cdd:cd19531     35 PLDVAALERALNELVARHEALRTTFVEVDGEPVqviLPPLPLPLPVVDLsgLPEAEREAEAQRLAREEARRPFDLARGPL 114

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2279 LRALLATLGDGSQRLLLVIHHLVVDGVSWRILLEDLQTAYRQLQAGQAVALPAKTSAFKAWAERLQAHARDGGLEGERGY 2358
Cdd:cd19531    115 LRATLLRLGEDEHVLLLTMHHIVSDGWSMGVLLRELAALYAAFLAGRPSPLPPLPIQYADYAVWQREWLQGEVLERQLAY 194

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2359 WLAQLEGVST--ELPCD-------DREGAqsvrhvrSARTELTEEATRRLLQEApAAYRTQVNDLLLTALARVIGRWTGQ 2429
Cdd:cd19531    195 WREQLAGAPPvlELPTDrprpavqSFRGA-------RVRFTLPAELTAALRALA-RREGATLFMTLLAAFQVLLHRYSGQ 266


                   ..
gi 2183974163 2430 AD 2431
Cdd:cd19531    267 DD 268

PRK08633

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated

535-1007

1.04e-26

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated

Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 120.41 E-value: 1.04e-26

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  535 RLSYAELNALANRLAWRLREEgVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQYMIDDSGLRLLLSQ 614
Cdd:PRK08633   641 ELSYGKALTGALALARLLKRE-LKDEENVGILLPPSVAGALANLALLLAGKVPVNLNYTASEAALKSAIEQAQIKTVITS 719

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  615 QSVLARLPQSDGLQSLLLDD----LERLVHG---------------YPA---ENPDLPE-APDSLCYAIYTSGSTGQPKG 671
Cdd:PRK08633   720 RKFLEKLKNKGFDLELPENVkviyLEDLKAKiskvdkltallaarlLPArllKRLYGPTfKPDDTATIIFSSGSEGEPKG 799

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  672 VMVRHRALTNFVCSIARQPGMLARDRLLSVTTFsFDIFGL--ELYVPLARGASMllASREQAQDPEALLDLVERQGVTVL 749
Cdd:PRK08633   800 VMLSHHNILSNIEQISDVFNLRNDDVILSSLPF-FHSFGLtvTLWLPLLEGIKV--VYHPDPTDALGIAKLVAKHRATIL 876

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  750 QATPATWRMLCDSERVDLLRGCTL---LCGGEALAEDLAA--RMR-------GlsastwnlYGPTETT------------ 805
Cdd:PRK08633   877 LGTPTFLRLYLRNKKLHPLMFASLrlvVAGAEKLKPEVADafEEKfgirileG--------YGATETSpvasvnlpdvla 948

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  806 --IWSARF-RLGEearpfLGGPLENTALYILDSE-MNPCPPGVAGELLIGGDGLARGYHRRPGLTAErFLPDpfaADGSR 881
Cdd:PRK08633   949 adFKRQTGsKEGS-----VGMPLPGVAVRIVDPEtFEELPPGEDGLILIGGPQVMKGYLGDPEKTAE-VIKD---IDGIG 1019

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  882 LYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRL---LEQDSVREAVVVaqpgvagptlvaylVPTE----- 953
Cdd:PRK08633  1020 WYVTGDKGHLDEDGFLTITDRYSRFAKIGGEMVPLGAVEEELakaLGGEEVVFAVTA--------------VPDEkkgek 1085

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2183974163  954 -AALVDAESARQQELRSALKNSllaVLPDYMVPAHMLLLENLPLTPNGKINRKAL 1007
Cdd:PRK08633  1086 lVVLHTCGAEDVEELKRAIKES---GLPNLWKPSRYFKVEALPLLGSGKLDLKGL 1137

ttLC_FACS_AEE21_like

cd12118

Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; This ...

524-1002

1.21e-26

Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; This family includes fatty acyl-CoA synthetases that can activate medium to long-chain fatty acids. These enzymes catalyze the ATP-dependent acylation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. Fatty acyl-CoA synthetases are responsible for fatty acid degradation as well as physiological regulation of cellular functions via the production of fatty acyl-CoA esters. The fatty acyl-CoA synthetase from Thermus thermophiles in this family has been shown to catalyze the long-chain fatty acid, myristoyl acid. Also included in this family are acyl activating enzymes from Arabidopsis, which contains a large number of proteins from this family with up to 63 different genes, many of which are uncharacterized.

Pssm-ID: 341283 [Multi-domain] Cd Length: 486 Bit Score: 117.01 E-value: 1.21e-26

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  524 PDAPALLFGEERLSYAELNALANRLAWRLREEGVGSDVLVGiALERGVP-MVVALLAVLKAGGAYVPLDPQYPADRLQYM 602
Cdd:cd12118     18 PDRTSIVYGDRRYTWRQTYDRCRRLASALAALGISRGDTVA-VLAPNTPaMYELHFGVPMAGAVLNALNTRLDAEEIAFI 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  603 IDDSGLRLLLSQQSvlarlpqsdglqsLLLDDLerLVHGypaeNPD-LPEAPDSLCYAI---YTSGSTGQPKGVMVRHR- 677
Cdd:cd12118     97 LRHSEAKVLFVDRE-------------FEYEDL--LAEG----DPDfEWIPPADEWDPIalnYTSGTTGRPKGVVYHHRg 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  678 ALTNFVCSIARQpGMlardRLLSVTTFSFDIF-----GLELYVPLARGASMLLasREQaqDPEALLDLVERQGVTVLQAT 752
Cdd:cd12118    158 AYLNALANILEW-EM----KQHPVYLWTLPMFhcngwCFPWTVAAVGGTNVCL--RKV--DAKAIYDLIEKHKVTHFCGA 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  753 PATWRMLCD---SERVDLLRGCTLLCGGEALAEDLAARMRGLSASTWNLYGPTETT------IWSA---------RFRLg 814
Cdd:cd12118    229 PTVLNMLANappSDARPLPHRVHVMTAGAPPPAAVLAKMEELGFDVTHVYGLTETYgpatvcAWKPewdelpteeRARL- 307

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  815 eEARPFLGGPLEnTALYILDSE-MNPCP-PGV-AGELLIGGDGLARGYHRRPGLTAERFlpdpfaADGsrLYRTGDLARY 891
Cdd:cd12118    308 -KARQGVRYVGL-EEVDVLDPEtMKPVPrDGKtIGEIVFRGNIVMKGYLKNPEATAEAF------RGG--WFHSGDLAVI 377

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  892 RADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQPGVA-GPTLVAYLvpteaALVDAESARQQELRSA 970
Cdd:cd12118    378 HPDGYIEIKDRSKDIIISGGENISSVEVEGVLYKHPAVLEAAVVARPDEKwGEVPCAFV-----ELKEGAKVTEEEIIAF 452

                          490       500       510
                   ....*....|....*....|....*....|..
gi 2183974163  971 LKNSllavLPDYMVPAHMLLLEnLPLTPNGKI 1002
Cdd:cd12118    453 CREH----LAGFMVPKTVVFGE-LPKTSTGKI 479

A_NRPS_TubE_like

cd05906

The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) ...

532-1007

1.21e-26

Pssm-ID: 341232 [Multi-domain] Cd Length: 540 Bit Score: 117.77 E-value: 1.21e-26

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  532 GEERLSYAELNALANRLAWRLREEGV--GSDVLVGIALERGVpmVVALLAVLKAGGAYVPLDP----QYPADRLQYM--- 602
Cdd:cd05906     36 SEEFQSYQDLLEDARRLAAGLRQLGLrpGDSVILQFDDNEDF--IPAFWACVLAGFVPAPLTVpptyDEPNARLRKLrhi 113

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  603 ---------IDDSGLRLLLSQQSVLARLPQSDGLQSLLLDDLERLVHGYPAEnpdlpeaPDSLCYAIYTSGSTGQPKGVM 673
Cdd:cd05906    114 wqllgspvvLTDAELVAEFAGLETLSGLPGIRVLSIEELLDTAADHDLPQSR-------PDDLALLMLTSGSTGFPKAVP 186

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  674 VRHRALTNFVCSIARQPGMLARDRLLSvtTFSFDIFG--LELYV-PLARGASML-LASREQAQDPEALLDLVERQGVTVl 749
Cdd:cd05906    187 LTHRNILARSAGKIQHNGLTPQDVFLN--WVPLDHVGglVELHLrAVYLGCQQVhVPTEEILADPLRWLDLIDRYRVTI- 263

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  750 qatpaTW------RMLCDSERV------DLLRGCTLLCGGEAL----AEDLAARMR--GLSAS----TWnlyGPTET--- 804
Cdd:cd05906    264 -----TWapnfafALLNDLLEEiedgtwDLSSLRYLVNAGEAVvaktIRRLLRLLEpyGLPPDairpAF---GMTETcsg 335

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  805 TIWSARFRLGE--EARPF--LGGPLENTALYILDSEMNPCPPGVAGELLIGGDGLARGYHRRPGLTAERFLPDPFaadgs 880
Cdd:cd05906    336 VIYSRSFPTYDhsQALEFvsLGRPIPGVSMRIVDDEGQLLPEGEVGRLQVRGPVVTKGYYNNPEANAEAFTEDGW----- 410

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  881 rlYRTGDLArYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVRE----AVVVAQPGVAGPTLVAYLVPtEAAL 956
Cdd:cd05906    411 --FRTGDLG-FLDNGNLTITGRTKDTIIVNGVNYYSHEIEAAVEEVPGVEPsftaAFAVRDPGAETEELAIFFVP-EYDL 486

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2183974163  957 VDAESARQQELRSALKNSlLAVLPDYMVPahmLLLENLPLTPNGKINRKAL 1007
Cdd:cd05906    487 QDALSETLRAIRSVVSRE-VGVSPAYLIP---LPKEEIPKTSLGKIQRSKL 533

PRK06710

long-chain-fatty-acid--CoA ligase; Validated

510-1007

1.28e-26

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 180666 [Multi-domain] Cd Length: 563 Bit Score: 117.83 E-value: 1.28e-26

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  510 QGVHRLFEAQAGLTPDAPALLFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVP 589
Cdd:PRK06710    24 QPLHKYVEQMASRYPEKKALHFLGKDITFSVFHDKVKRFANYLQKLGVEKGDRVAIMLPNCPQAVIGYYGTLLAGGIVVQ 103

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  590 LDPQYPADRLQYMIDDSGLRLLLSQQSVLAR---------------------LPQSDGL--------QSLLLDDLER--L 638
Cdd:PRK06710   104 TNPLYTERELEYQLHDSGAKVILCLDLVFPRvtnvqsatkiehvivtriadfLPFPKNLlypfvqkkQSNLVVKVSEseT 183

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  639 VHGYPAENPDLPEAPDSLC-------YAIYTSGSTGQPKGVMVRHRAL-TNFVCSIARQPGML-ARDRLLSVTTFsFDIF 709
Cdd:PRK06710   184 IHLWNSVEKEVNTGVEVPCdpendlaLLQYTGGTTGFPKGVMLTHKNLvSNTLMGVQWLYNCKeGEEVVLGVLPF-FHVY 262

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  710 GLELYVPLA--RGASMLLASReqaQDPEALLDLVERQGVTVLQATPATWRMLCDSE-----RVDLLRGCtlLCGGEALAE 782
Cdd:PRK06710   263 GMTAVMNLSimQGYKMVLIPK---FDMKMVFEAIKKHKVTLFPGAPTIYIALLNSPllkeyDISSIRAC--ISGSAPLPV 337

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  783 DLAARMRGLSASTW-NLYGPTETTIWSARFRLGEEARP-FLGGPLENTALYILDSEMNPC-PPGVAGELLIGGDGLARGY 859
Cdd:PRK06710   338 EVQEKFETVTGGKLvEGYGLTESSPVTHSNFLWEKRVPgSIGVPWPDTEAMIMSLETGEAlPPGEIGEIVVKGPQIMKGY 417

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  860 HRRPGLTAERFlpdpfaADGsrLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQPG 939
Cdd:PRK06710   418 WNKPEETAAVL------QDG--WLHTGDVGYMDEDGFFYVKDRKKDMIVASGFNVYPREVEEVLYEHEKVQEVVTIGVPD 489

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2183974163  940 -VAGPTLVAYLVpteaaLVDAESARQQELRSALKNSLLAvlpdYMVPAHMLLLENLPLTPNGKINRKAL 1007
Cdd:PRK06710   490 pYRGETVKAFVV-----LKEGTECSEEELNQFARKYLAA----YKVPKVYEFRDELPKTTVGKILRRVL 549

Cyc_NRPS

Cyc (heterocyclization) domain of nonribosomal peptide synthetases (NRPSs); belongs to the ...

82-371

1.29e-26

Cyc (heterocyclization) domain of nonribosomal peptide synthetases (NRPSs); belongs to the Condensation-domain family; Cyc (heterocyclization) domains catalyze two separate reactions in the creation of heterocyclized peptide products in nonribosomal peptide synthesis: amide bond formation followed by intramolecular cyclodehydration between a Cys, Ser, or Thr side chain and a carbonyl carbon on the peptide backbone to form a thiazoline, oxazoline, or methyloxazoline ring. Cyc-domains are homologous to standard NRPS Condensation (C) domains. C-domains typically have a conserved HHxxxD motif at the active site; Cyc-domains have an alternative, conserved DxxxxD active site motif, mutation of the aspartate residues in this motif can abolish or diminish condensation activity. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long (with various activities such as antibiotic, antifungal, antitumor and immunosuppression). There are various subtypes of C-domains such as the LCL-type which catalyzes peptide bond formation between two L-amino acids, the DCL-type which links an L-amino acid to the D-amino acid at the end of a growing peptide, starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and Cyc-domains. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the epimerization (E) domain, the ester-bond forming C-domain, dual E/C (epimerization and condensation) domains, and the X-domain.

Pssm-ID: 380458 [Multi-domain] Cd Length: 423 Bit Score: 115.66 E-value: 1.29e-26

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163   82 LDVEALSASLGAIVERHQSLRTVFvedeqLDGFRQQVLASVDVP-VPV---TLAGDDDAQAQIRAFVESETQQPFDLRNG 157
Cdd:cd19535     37 LDPDRLERAWNKLIARHPMLRAVF-----LDDGTQQILPEVPWYgITVhdlRGLSEEEAEAALEELRERLSHRVLDVERG 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  158 PLLRARLLRLAADDHVLTLTIHHVAADGWSMRVLVEELIALYGARrqgiEATLPDLPIQYADYAIWQRHwLEAGERERQL 237
Cdd:cd19535    112 PLFDIRLSLLPEGRTRLHLSIDLLVADALSLQILLRELAALYEDP----GEPLPPLELSFRDYLLAEQA-LRETAYERAR 186

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  238 EYWMARLgggqsvLELPTdrqRPALP---------SYRGARHELQLPQALGRQLQALAQREGTTLFMLLLASFQALLHRY 308
Cdd:cd19535    187 AYWQERL------PTLPP---APQLPlakdpeeikEPRFTRREHRLSAEQWQRLKERARQHGVTPSMVLLTAYAEVLARW 257

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2183974163  309 SGQDEIRVGVPVANRNRV--ETERLIGFFVNTQVLRADLDAQMPFLDllqqtRVAALGAQSHQDL 371
Cdd:cd19535    258 SGQPRFLLNLTLFNRLPLhpDVNDVVGDFTSLLLLEVDGSEGQSFLE-----RARRLQQQLWEDL 317

MACS_like_1

cd05974

Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the ...

536-1007

1.67e-26

Pssm-ID: 341278 [Multi-domain] Cd Length: 432 Bit Score: 115.74 E-value: 1.67e-26

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  536 LSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQymiddsglrlllsqq 615
Cdd:cd05974      1 VSFAEMSARSSRVANFLRSIGVGRGDRILLMLGNVVELWEAMLAAMKLGAVVIPATTLLTPDDLR--------------- 65

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  616 svlarlpqsdglqslllDDLERLVHGYPAENpDLPEAPDSLCYaIYTSGSTGQPKGVMVRHRALTNFVCSIARQPGMLAR 695
Cdd:cd05974     66 -----------------DRVDRGGAVYAAVD-ENTHADDPMLL-YFTSGTTSKPKLVEHTHRSYPVGHLSTMYWIGLKPG 126

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  696 DRLLSVTTFSFDIFGLE-LYVPLARGASMLLASrEQAQDPEALLDLVERQGVTVLQATPATWRMLCDSERVDLLRGCTLL 774
Cdd:cd05974    127 DVHWNISSPGWAKHAWScFFAPWNAGATVFLFN-YARFDAKRVLAALVRYGVTTLCAPPTVWRMLIQQDLASFDVKLREV 205

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  775 CG-GEALAEDLAARMRGLsastWNL-----YGPTETTIWSARfRLGEEARP-FLGGPLENTALYILDSEMNPCPPGVAGe 847
Cdd:cd05974    206 VGaGEPLNPEVIEQVRRA----WGLtirdgYGQTETTALVGN-SPGQPVKAgSMGRPLPGYRVALLDPDGAPATEGEVA- 279

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  848 LLIGGD---GLARGYHRRPGLTAErflpdpfaADGSRLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLL 924
Cdd:cd05974    280 LDLGDTrpvGLMKGYAGDPDKTAH--------AMRGGYYRTGDIAMRDEDGYLTYVGRADDVFKSSDYRISPFELESVLI 351

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  925 EQDSVREAVVVAQPgvaGPTLVAylVPTEAALVDAESARQQELRSALKNSLLAVLPDYMVPAHMLLLEnLPLTPNGKINR 1004
Cdd:cd05974    352 EHPAVAEAAVVPSP---DPVRLS--VPKAFIVLRAGYEPSPETALEIFRFSRERLAPYKRIRRLEFAE-LPKTISGKIRR 425


                   ...
gi 2183974163 1005 KAL 1007
Cdd:cd05974    426 VEL 428

entE

PRK10946

(2,3-dihydroxybenzoyl)adenylate synthase;

524-1007

1.75e-26

(2,3-dihydroxybenzoyl)adenylate synthase;

Pssm-ID: 236803 [Multi-domain] Cd Length: 536 Bit Score: 117.01 E-value: 1.75e-26

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  524 PDAPALLFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGgaYVPLDPQYPADRLQY-- 601
Cdd:PRK10946    37 SDAIAVICGERQFSYRELNQASDNLACSLRRQGIKPGDTALVQLGNVAEFYITFFALLKLG--VAPVNALFSHQRSELna 114

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  602 ---------MIDDSGLRLLLSQQSVLARLPQSDGLQSLLLD------DLERLVHGYPAENPDLPEAPDSLCYAIYTSGST 666
Cdd:PRK10946   115 yasqiepalLIADRQHALFSDDDFLNTLVAEHSSLRVVLLLnddgehSLDDAINHPAEDFTATPSPADEVAFFQLSGGST 194

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  667 GQPKGVMVRH-------RAlTNFVCSIARQPGML-----ARDRLLSvttfSFDIFGlelyVPLARGASMLlasreqAQDP 734
Cdd:PRK10946   195 GTPKLIPRTHndyyysvRR-SVEICGFTPQTRYLcalpaAHNYPMS----SPGALG----VFLAGGTVVL------APDP 259

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  735 EALL--DLVERQGVTVLQATP---ATW-RMLCDSERVDLLRGCTLL-CGGEALAEDLAARMRG-LSASTWNLYGPTETTI 806
Cdd:PRK10946   260 SATLcfPLIEKHQVNVTALVPpavSLWlQAIAEGGSRAQLASLKLLqVGGARLSETLARRIPAeLGCQLQQVFGMAEGLV 339

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  807 WSARFRLGEEaRPFL--GGPL-ENTALYILDSEMNPCPPGVAGELLIGGDGLARGYHRRPGLTAERFLPDPFaadgsrlY 883
Cdd:PRK10946   340 NYTRLDDSDE-RIFTtqGRPMsPDDEVWVADADGNPLPQGEVGRLMTRGPYTFRGYYKSPQHNASAFDANGF-------Y 411

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  884 RTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQP-GVAGPTLVAYLVPTEAalvdaesA 962
Cdd:PRK10946   412 CSGDLVSIDPDGYITVVGREKDQINRGGEKIAAEEIENLLLRHPAVIHAALVSMEdELMGEKSCAFLVVKEP-------L 484

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*
gi 2183974163  963 RQQELRSALKNSLLAvlpDYMVPAHMLLLENLPLTPNGKINRKAL 1007
Cdd:PRK10946   485 KAVQLRRFLREQGIA---EFKLPDRVECVDSLPLTAVGKVDKKQL 526

EntF

EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites ...

2174-2600

2.29e-26

EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism];

Pssm-ID: 440643 [Multi-domain] Cd Length: 1329 Bit Score: 119.58 E-value: 2.29e-26

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2174 PLLPIQQMFFELDIPRRQHWNQSVLLEPGQALDGTLLETALQALLAHHDALRLGFRLEDGTWRAEHRAVEAGEVLLWQQS 2253
Cdd:COG1020     21 SAAQQRLWLLLLLLLGSAAYNLALALLLLGLLLVAALLLLAALLARRRRALRTRLRTRAGRPVQVIQPVVAAPLPVVVLL 100

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2254 V-----ADGQALEALAEQVQRSLDLGSGPLLRALLATLGDGSQRLLLVIHHLVVDGVSWRILLEDLQTAYRQLQAGQAVA 2328
Cdd:COG1020    101 VdlealAEAAAEAAAAAEALAPFDLLRGPLLRLLLLLLLLLLLLLLLALHHIISDGLSDGLLLAELLRLYLAAYAGAPLP 180

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2329 LPAKTSAFKAWAERLQAHARDGGLEGERGYWLAQLEG--VSTELPCDDREGAQSVRHVRSARTELTEEATRRLLQEApAA 2406
Cdd:COG1020    181 LPPLPIQYADYALWQREWLQGEELARQLAYWRQQLAGlpPLLELPTDRPRPAVQSYRGARVSFRLPAELTAALRALA-RR 259

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2407 YRTQVNDLLLTALARVIGRWTGQADTLIQLEGHGReelfEDIDLTRTVGWFTSLFPLRL-----SPVAELGASIKRikEQ 2481
Cdd:COG1020    260 HGVTLFMVLLAAFALLLARYSGQDDVVVGTPVAGR----PRPELEGLVGFFVNTLPLRVdlsgdPSFAELLARVRE--TL 333

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2482 LRAIPHKGLGFGALRylgsaeDRAALAALPSPRITFNYLGQFDgSFSADSSALfrPSADAAGSERDSDAPlDNWLSLNGQ 2561
Cdd:COG1020    334 LAAYAHQDLPFERLV------EELQPERDLSRNPLFQVMFVLQ-NAPADELEL--PGLTLEPLELDSGTA-KFDLTLTVV 403

                          410       420       430
                   ....*....|....*....|....*....|....*....
gi 2183974163 2562 VYAGRLGIDWSFSAARFSEASILRLADAYRDELLALIEH 2600
Cdd:COG1020    404 ETGDGLRLTLEYNTDLFDAATIERMAGHLVTLLEALAAD 442

PRK08279

long-chain-acyl-CoA synthetase; Validated

1574-2055

3.97e-26

long-chain-acyl-CoA synthetase; Validated

Pssm-ID: 236217 [Multi-domain] Cd Length: 600 Bit Score: 116.90 E-value: 3.97e-26

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1574 IERQAAERPRATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYP 1653
Cdd:PRK08279    43 FEEAAARHPDRPALLFEDQSISYAELNARANRYAHWAAARGVGKGDVVALLMENRPEYLAAWLGLAKLGAVVALLNTQQR 122

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1654 SDRLGYMIEDSGIRLLLTQRAARERL-----------------PLGEGLPCLLLDAEHEWAGYPESDPQSAVGV--DNLA 1714
Cdd:PRK08279   123 GAVLAHSLNLVDAKHLIVGEELVEAFeearadlarpprlwvagGDTLDDPEGYEDLAAAAAGAPTTNPASRSGVtaKDTA 202

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1715 YVIYTSGSTGKPKGTLLPHGNVLRlfdaTRHWFGFSAD--------DAWSLFHSYAFdFSVWEifGALLHGGRLVIVP-Y 1785
Cdd:PRK08279   203 FYIYTSGTTGLPKAAVMSHMRWLK----AMGGFGGLLRltpddvlyCCLPLYHNTGG-TVAWS--SVLAAGATLALRRkF 275

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1786 ETSRspedFLRLLCRERVTV-----------LNQTPSafkqlmqvacagqevpPLALRH---VVFGgealevQALRP--- 1848
Cdd:PRK08279   276 SASR----FWDDVRRYRATAfqyigelcrylLNQPPK----------------PTDRDHrlrLMIG------NGLRPdiw 329

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1849 --WFERFGdrAPRLVNMYGITETTVhvtyrplSLADLDG--GA--------ASPI---------GEPIPDlswyllDAG- 1906
Cdd:PRK08279   330 deFQQRFG--IPRILEFYAASEGNV-------GFINVFNfdGTvgrvplwlAHPYaivkydvdtGEPVRD------ADGr 394

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1907 LNPVPRGCIGELY--VGGAGLARGYlNRPELSCTRFVADPFsTTGGRLYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRI 1984
Cdd:PRK08279   395 CIKVKPGEVGLLIgrITDRGPFDGY-TDPEASEKKILRDVF-KKGDAWFNTGDLMRDDGFGHAQFVDRLGDTFRWKGENV 472

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2183974163 1985 ELGEIEARLLAQPGVAEAVVLPHEGPGATQLVGY---VVTQAAPSDPAALRDTLRQAlkasLPEHMVPahlLFL 2055
Cdd:PRK08279   473 ATTEVENALSGFPGVEEAVVYGVEVPGTDGRAGMaaiVLADGAEFDLAALAAHLYER----LPAYAVP---LFV 539

PRK13391

acyl-CoA synthetase; Provisional

1575-2071

8.11e-26

acyl-CoA synthetase; Provisional

Pssm-ID: 184022 [Multi-domain] Cd Length: 511 Bit Score: 114.79 E-value: 8.11e-26

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1575 ERQAAERPRATAVVYGE--RALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRY 1652
Cdd:PRK13391     4 GIHAQTTPDKPAVIMAStgEVVTYRELDERSNRLAHLFRSLGLKRGDHVAIFMENNLRYLEVCWAAERSGLYYTCVNSHL 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1653 PSDRLGYMIEDSGIRLLLTQRAARE-------RLPlgEGLPCLLLDAEHE---WAGYPESD--------PQSAVGVDNLa 1714
Cdd:PRK13391    84 TPAEAAYIVDDSGARALITSAAKLDvarallkQCP--GVRHRLVLDGDGElegFVGYAEAVaglpatpiADESLGTDML- 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1715 yviYTSGSTGKPKGTL--LPHGNV---LRLFDATRHWFGFSADDAW----SLFHSYAFDFSvweifGALLHGGRLVIVpY 1785
Cdd:PRK13391   161 ---YSSGTTGRPKGIKrpLPEQPPdtpLPLTAFLQRLWGFRSDMVYlspaPLYHSAPQRAV-----MLVIRLGGTVIV-M 231

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1786 ETSrSPEDFLRLLCRERVTVLNQTPSAFKQLMQVACAGQEVPPLA-LRHVVFGGEALEVQALRPWFERFGdraPRLVNMY 1864
Cdd:PRK13391   232 EHF-DAEQYLALIEEYGVTHTQLVPTMFSRMLKLPEEVRDKYDLSsLEVAIHAAAPCPPQVKEQMIDWWG---PIIHEYY 307

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1865 GITETTVHVTYRPLSLADLDGGAASPI-GEPipdlswYLLDAGLNPVPRGCIGELYVGGaGLARGYLNRPELSCTRFVAD 1943
Cdd:PRK13391   308 AATEGLGFTACDSEEWLAHPGTVGRAMfGDL------HILDDDGAELPPGEPGTIWFEG-GRPFEYLNDPAKTAEARHPD 380

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1944 PFSTTggrlyrTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVV--LPHEGPGatQLVGYVVT 2021
Cdd:PRK13391   381 GTWST------VGDIGYVDEDGYLYLTDRAAFMIISGGVNIYPQEAENLLITHPKVADAAVfgVPNEDLG--EEVKAVVQ 452

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2183974163 2022 QAAPSDP-AALRDTLRQALKASLPEHMVPAHLLFLERLPLTANGKLDRRAL 2071
Cdd:PRK13391   453 PVDGVDPgPALAAELIAFCRQRLSRQKCPRSIDFEDELPRLPTGKLYKRLL 503

Firefly_Luc

cd17642

insect luciferase, similar to plant 4-coumarate: CoA ligases; This family contains insect ...

1559-2071

9.73e-26

insect luciferase, similar to plant 4-coumarate: CoA ligases; This family contains insect firefly luciferases that share significant sequence similarity to plant 4-coumarate:coenzyme A ligases, despite their functional diversity. Luciferase catalyzes the production of light in the presence of MgATP, molecular oxygen, and luciferin. In the first step, luciferin is activated by acylation of its carboxylate group with ATP, resulting in an enzyme-bound luciferyl adenylate. In the second step, luciferyl adenylate reacts with molecular oxygen, producing an enzyme-bound excited state product (Luc=O*) and releasing AMP. This excited-state product then decays to the ground state (Luc=O), emitting a quantum of visible light.

Pssm-ID: 341297 [Multi-domain] Cd Length: 532 Bit Score: 114.93 E-value: 9.73e-26

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1559 PGP----QDFTPASCLHRLIERQAaERPRATAVV--YGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMI 1632
Cdd:cd17642      5 PGPfyplEDGTAGEQLHKAMKRYA-SVPGTIAFTdaHTGVNYSYAEYLEMSVRLAEALKKYGLKQNDRIAVCSENSLQFF 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1633 VGLLAILKAGGAYVPLDPRYPSDRLGYMIEDSGIRLLLTQRAARER-------LPLGEGLpcLLLDAEHEWAGYPESD-- 1703
Cdd:cd17642     84 LPVIAGLFIGVGVAPTNDIYNERELDHSLNISKPTIVFCSKKGLQKvlnvqkkLKIIKTI--IILDSKEDYKGYQCLYtf 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1704 ---------------PQSAVGVDNLAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRH-WFGFSADDAWSLFHSYAF--DF 1765
Cdd:cd17642    162 itqnlppgfneydfkPPSFDRDEQVALIMNSSGSTGLPKGVQLTHKNIVARFSHARDpIFGNQIIPDTAILTVIPFhhGF 241

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1766 SVWEIFGALLHGGRLVIVP-YETsrspEDFLRLLCRERVTVLNQTPSAF--------------KQLMQVACAGQevpPLA 1830
Cdd:cd17642    242 GMFTTLGYLICGFRVVLMYkFEE----ELFLRSLQDYKVQSALLVPTLFaffakstlvdkydlSNLHEIASGGA---PLS 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1831 lRHVvfgGEALEvqalrpwfERFGdrAPRLVNMYGITETTVHVTYRPLSlaDLDGGAaspIGEPIPDLSWYL--LDAG-- 1906
Cdd:cd17642    315 -KEV---GEAVA--------KRFK--LPGIRQGYGLTETTSAILITPEG--DDKPGA---VGKVVPFFYAKVvdLDTGkt 375

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1907 LNPVPRGcigELYVGGAGLARGYLNRPELSCTRFVADpfsttgGRLyRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIEL 1986
Cdd:cd17642    376 LGPNERG---ELCVKGPMIMKGYVNNPEATKALIDKD------GWL-HSGDIAYYDEDGHFFIVDRLKSLIKYKGYQVPP 445

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1987 GEIEARLLAQPGVAEAVV--LPHEG----PGA------------TQLVGYVVTQAAPSDpaalrdTLRQALKaslpehmv 2048
Cdd:cd17642    446 AELESILLQHPKIFDAGVagIPDEDagelPAAvvvleagktmteKEVMDYVASQVSTAK------RLRGGVK-------- 511

                          570       580
                   ....*....|....*....|...
gi 2183974163 2049 pahllFLERLPLTANGKLDRRAL 2071
Cdd:cd17642    512 -----FVDEVPKGLTGKIDRRKI 529

PRK07788

acyl-CoA synthetase; Validated

514-1008

2.75e-25

acyl-CoA synthetase; Validated

Pssm-ID: 236097 [Multi-domain] Cd Length: 549 Bit Score: 113.48 E-value: 2.75e-25

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  514 RLFEAQAGLTPDAPALLFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQ 593
Cdd:PRK07788    53 GLVAHAARRAPDRAALIDERGTLTYAELDEQSNALARGLLALGVRAGDGVAVLARNHRGFVLALYAAGKVGARIILLNTG 132

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  594 YPADRLQYMIDDSGLRLLLSQQSVLARL----------------PQSDGLQSLLLDDLERLVHGYPAENPDLPEAPDSLc 657
Cdd:PRK07788   133 FSGPQLAEVAAREGVKALVYDDEFTDLLsalppdlgrlrawggnPDDDEPSGSTDETLDDLIAGSSTAPLPKPPKPGGI- 211

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  658 yAIYTSGSTGQPKGVMVRH-RALTNFVCSIARQPgmLARDRLLSVTTFSFDIFGL-ELYVPLARGASMLLASReqaQDPE 735
Cdd:PRK07788   212 -VILTSGTTGTPKGAPRPEpSPLAPLAGLLSRVP--FRAGETTLLPAPMFHATGWaHLTLAMALGSTVVLRRR---FDPE 285

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  736 ALLDLVERQGVTVLQATPATWRMLCD-----SERVDL--LRgcTLLCGGEALAEDLAAR-MRGLSASTWNLYGPTETTIW 807
Cdd:PRK07788   286 ATLEDIAKHKATALVVVPVMLSRILDlgpevLAKYDTssLK--IIFVSGSALSPELATRaLEAFGPVLYNLYGSTEVAFA 363

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  808 S-ARFRLGEEARPFLGGPLENTALYILDSEMNPCPPGVAGELLIGGDGLARGYhrrpglTAERflpDPFAADGsrLYRTG 886
Cdd:PRK07788   364 TiATPEDLAEAPGTVGRPPKGVTVKILDENGNEVPRGVVGRIFVGNGFPFEGY------TDGR---DKQIIDG--LLSSG 432

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  887 DLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVaqpGVA----GPTLVAYLVPTEAALVDAEsa 962
Cdd:PRK07788   433 DVGYFDEDGLLFVDGRDDDMIVSGGENVFPAEVEDLLAGHPDVVEAAVI---GVDdeefGQRLRAFVVKAPGAALDED-- 507

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*.
gi 2183974163  963 rqqELRSALKNSllavLPDYMVPAHMLLLENLPLTPNGKINRKALP 1008
Cdd:PRK07788   508 ---AIKDYVRDN----LARYKVPRDVVFLDELPRNPTGKVLKRELR 546

SgcC5_NRPS-like

SgcC5 is a non-ribosomal peptide synthetase (NRPS) condensation enzyme with ester- and amide- ...

2204-2597

2.78e-25

Pssm-ID: 380462 [Multi-domain] Cd Length: 427 Bit Score: 111.70 E-value: 2.78e-25

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2204 ALDGTLLETALQALLAHHDALRLGF-RLEDGTWRAEHRAVEAGEVLLWQQSVADG---QALEALAEQVQ-RSLDLGSGPL 2278
Cdd:cd19539     35 PLDVEALREALRDVVARHEALRTLLvRDDGGVPRQEILPPGPAPLEVRDLSDPDSdreRRLEELLREREsRGFDLDEEPP 114

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2279 LRALLATLGDGSQRLLLVIHHLVVDGVSWRILLEDLQTAYRQLQAGQAVALPAKTSAFKAWAERLQAHARDGGLEGERGY 2358
Cdd:cd19539    115 IRAVLGRFDPDDHVLVLVAHHTAFDAWSLDVFARDLAALYAARRKGPAAPLPELRQQYKEYAAWQREALAAPRAAELLDF 194

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2359 WLAQLEGVS-TELPCDDREGAQSVRHVRSARTELTEEATRRLLQEAPAAyRTQVNDLLLTALARVIGRWTGQADTLIQLE 2437
Cdd:cd19539    195 WRRRLRGAEpTALPTDRPRPAGFPYPGADLRFELDAELVAALRELAKRA-RSSLFMVLLAAYCVLLRRYTGQTDIVVGTP 273

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2438 GHGREElfedIDLTRTVGWFTSLFPLR--LSPVAELGASIKRI-KEQLRAIPHKGLGFGALrylgSAEDRAALAALPSPR 2514
Cdd:cd19539    274 VAGRNH----PRFESTVGFFVNLLPLRvdVSDCATFRDLIARVrKALVDAQRHQELPFQQL----VAELPVDRDAGRHPL 345

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2515 --ITFNYLGQFDGSFSADSSALFRPsadaaGSERDSDAPLDnwLSLNGQVYAGRLGIDWSFSAARFSEASILRLADAYRD 2592
Cdd:cd19539    346 vqIVFQVTNAPAGELELAGGLSYTE-----GSDIPDGAKFD--LNLTVTEEGTGLRGSLGYATSLFDEETIQGFLADYLQ 418


                   ....*
gi 2183974163 2593 ELLAL 2597
Cdd:cd19539    419 VLRQL 423

PRK05677

long-chain-fatty-acid--CoA ligase; Validated

1697-2071

3.76e-25

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 168170 [Multi-domain] Cd Length: 562 Bit Score: 113.32 E-value: 3.76e-25

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1697 AGYP--ESDPQSavgvDNLAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRHWFGFSADDA-------WSLFHSYAFDFSV 1767
Cdd:PRK05677   195 AGQPvtEANPQA----DDVAVLQYTGGTTGVAKGAMLTHRNLVANMLQCRALMGSNLNEGceiliapLPLYHIYAFTFHC 270

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1768 WEIfgaLLHGGRLVIVPyeTSRSPEDFLRLLCRERVTVLNQTPSAFKQLmqvaCAGQEVPPL---ALRHVVFGGEALEVQ 1844
Cdd:PRK05677   271 MAM---MLIGNHNILIS--NPRDLPAMVKELGKWKFSGFVGLNTLFVAL----CNNEAFRKLdfsALKLTLSGGMALQLA 341

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1845 ALRPWFERFGdraPRLVNMYGITETTVHVTYRPLSLADLdggaaSPIGEPIPDLSWYLLDAGLNPVPRGCIGELYVGGAG 1924
Cdd:PRK05677   342 TAERWKEVTG---CAICEGYGMTETSPVVSVNPSQAIQV-----GTIGIPVPSTLCKVIDDDGNELPLGEVGELCVKGPQ 413

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1925 LARGYLNRPELSCTRFVADPFsttggrlYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAE--A 2002
Cdd:PRK05677   414 VMKGYWQRPEATDEILDSDGW-------LKTGDIALIQEDGYMRIVDRKKDMILVSGFNVYPNELEDVLAALPGVLQcaA 486

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2183974163 2003 VVLPHEGPGATQLVgYVVtqaAPSDPAALRDTLRQALKASLPEHMVPAHLLFLERLPLTANGKLDRRAL 2071
Cdd:PRK05677   487 IGVPDEKSGEAIKV-FVV---VKPGETLTKEQVMEHMRANLTGYKVPKAVEFRDELPTTNVGKILRREL 551

SgcC5_NRPS-like

SgcC5 is a non-ribosomal peptide synthetase (NRPS) condensation enzyme with ester- and amide- ...

2639-2980

4.12e-25

Pssm-ID: 380462 [Multi-domain] Cd Length: 427 Bit Score: 111.32 E-value: 4.12e-25

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2639 PLSPMQQGMLFHSLYQQNSGDYINQMRLDVEG-LDPQRFREAWQAALDAHEVLRSGFLWQGALEkPLQLVRKRVEVPFSV 2717
Cdd:cd19539      3 PLSFAQERLWFIDQGEDGGPAYNIPGAWRLTGpLDVEALREALRDVVARHEALRTLLVRDDGGV-PRQEILPPGPAPLEV 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2718 HDWRDRADLAEALDALAAGEA-GLGFELAEAPLLRLVLVRTGERRHHLIYTNHHILMDGWSNSQLLGEVLQRYRGETPSR 2796
Cdd:cd19539     82 RDLSDPDSDRERRLEELLREReSRGFDLDEEPPIRAVLGRFDPDDHVLVLVAHHTAFDAWSLDVFARDLAALYAARRKGP 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2797 S------DGRYRDYIAWLQRQDAGRTEA----FWKQRLQRLGEPTLLVPAFAHGVRGAEGHADRYRQLDVTTSQrLAEFA 2866
Cdd:cd19539    162 AaplpelRQQYKEYAAWQREALAAPRAAelldFWRRRLRGAEPTALPTDRPRPAGFPYPGADLRFELDAELVAA-LRELA 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2867 REQKVTLNTLVQAAWLILLQRFTGQDTVAFGATVSGRPAElrGIEEQIGLFINTLPVVASPCPEQPIGDWLQAVQGENLA 2946
Cdd:cd19539    241 KRARSSLFMVLLAAYCVLLRRYTGQTDIVVGTPVAGRNHP--RFESTVGFFVNLLPLRVDVSDCATFRDLIARVRKALVD 318

                          330       340       350
                   ....*....|....*....|....*....|....*...
gi 2183974163 2947 LREFEHTPLYDIQRWAGQVGEA----LFDNILVFENYP 2980
Cdd:cd19539    319 AQRHQELPFQQLVAELPVDRDAgrhpLVQIVFQVTNAP 356

EntF2

COG3319

Thioesterase domain of type I polyketide synthase or non-ribosomal peptide synthetase ...

512-1113

4.81e-25

Thioesterase domain of type I polyketide synthase or non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism];

Pssm-ID: 442548 [Multi-domain] Cd Length: 855 Bit Score: 114.42 E-value: 4.81e-25

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  512 VHRLFEAQAGLTPDAPALLFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLD 591
Cdd:COG3319      3 AAAAAAAAAAAAAAAAAAAAAAAALAAAAAAAAAAALLLLAAALLVALAALALAALALAALLAVALLAAALALAALAALA 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  592 PQYPADRLQYMIDDSGLRLLLSQQSVLARLPQSDGLQSLLLDDLERLVHGYPAENPDLPEAPDSLCYAIYTSGSTGQPKG 671
Cdd:COG3319     83 ALALALAAAAAALLLAALALLLALLAALALALLALLLAALLLALAALAAAAAAAALAAAAAAAAALAAAAGLGGGGGGAG 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  672 VMVRHRALTNFVCSIARQPGMLARDRLLSVTTFSFDIFGLELYVPLARGASMLLASREQAQDPEALLDLVERQGVTVLQA 751
Cdd:COG3319    163 VLVLVLAALLALLLAALLALALALAALLLLALAAALALALLLLLALLLLLLLLLALLLLLLLALLAAAALLALLLALLLL 242

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  752 TPATWRMLCDSERVDLLRGCTLLCGGEALAEDLAARMRGLSASTWNLY------GPTETTIWSARFRLGEEARPFLGGPL 825
Cdd:COG3319    243 LLAALLLLLALALLLLLALLLLLGLLALLLALLLLLALLLLAAAAALAaggtatTAAVTTTAAAAAPGVAGALGPIGGGP 322

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  826 ENTALYILDSEMNPCPPGVAGELLIGGDGLARGYHRRPGLTAERFLPDPFAADGSRLYRTGDLARYRADGVIEYLGRIDH 905
Cdd:COG3319    323 GLLVLLVLLVLLLPLLLGVGGGGGGGGGGGGAGGLAGRGLRAAAALRDPAGAGARGRLRRGGDRGRRLGGGLLLGLGRLR 402

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  906 QVKIRGFRIELGEIETRLLEQDSVREAVVVAQPGVAGPTLVAYLVPTEAALVDAESARQQelrsalknsLLAVLPDYMVP 985
Cdd:COG3319    403 LQRLRRGLREELEEAEAALAEAAAVAAAVAAAAAAAAAAAALAAAVVAAAALAAAALLLL---------LLLLLLPPPLP 473

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  986 AHMLLLENLPLTPNGKINRKALPLPDASAVRDAHVAPEGELERAMAAIWSEVLKLGHIGRDDNFFELGGHSLLVTQVVSR 1065
Cdd:COG3319    474 PALLLLLLLLLLLLLAALLLAAAAPAAAAAAAAAPAPAAALELALALLLLLLLGLGLVGDDDDFFGGGGGSLLALLLLLL 553

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....*...
gi 2183974163 1066 VRRRLDLQVPLRTLFEHSTLRAYAQAVAQLAPAAQGGIVRCARDASPQ 1113
Cdd:COG3319    554 LLALLLRLLLLLALLLAPTLAALAAALAAAAAAAALSPLVPLRAGGSG 601

PRK08633

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated

1711-2071

6.61e-25

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated

Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 114.64 E-value: 6.61e-25

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1711 DNLAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRHWFGFSADD----AWSLFHSyaFDFSVwEIFGALLHGGRLVIVPye 1786
Cdd:PRK08633   782 DDTATIIFSSGSEGEPKGVMLSHHNILSNIEQISDVFNLRNDDvilsSLPFFHS--FGLTV-TLWLPLLEGIKVVYHP-- 856

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1787 tsrSPEDFL---RLLCRERVTVLNQTPSAFKQLMQvacaGQEVPPL---ALRHVVFGGEALEvQALRPWF-ERFGdraPR 1859
Cdd:PRK08633   857 ---DPTDALgiaKLVAKHRATILLGTPTFLRLYLR----NKKLHPLmfaSLRLVVAGAEKLK-PEVADAFeEKFG---IR 925

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1860 LVNMYGITETTVHVTyrpLSLAD-LDGGAAS-------PIGEPIPDLSWYLLDA-GLNPVPRGCIGELYVGGAGLARGYL 1930
Cdd:PRK08633   926 ILEGYGATETSPVAS---VNLPDvLAADFKRqtgskegSVGMPLPGVAVRIVDPeTFEELPPGEDGLILIGGPQVMKGYL 1002

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1931 NRPELScTRFVADpfsTTGGRLYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIE----ARLLAQPGVAEAVVLP 2006
Cdd:PRK08633  1003 GDPEKT-AEVIKD---IDGIGWYVTGDKGHLDEDGFLTITDRYSRFAKIGGEMVPLGAVEeelaKALGGEEVVFAVTAVP 1078

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2183974163 2007 HEGPGaTQLVgyVVTQAAPSDPAALRdtlRQALKASLPEHMVPAHLLFLERLPLTANGKLDRRAL 2071
Cdd:PRK08633  1079 DEKKG-EKLV--VLHTCGAEDVEELK---RAIKESGLPNLWKPSRYFKVEALPLLGSGKLDLKGL 1137

MenE/FadK

COG0318

O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) [Lipid ...

3087-3183

6.79e-25

Pssm-ID: 440087 [Multi-domain] Cd Length: 452 Bit Score: 111.06 E-value: 6.79e-25

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3087 VHRLFEEQVERTPTAPALAFGEERLDYAELNRRANRLAHALIERGIGADRLVGVAMERSIEMVVALMAILKAGGAYVPVD 3166
Cdd:COG0318      1 LADLLRRAAARHPDRPALVFGGRRLTYAELDARARRLAAALRALGVGPGDRVALLLPNSPEFVVAFLAALRAGAVVVPLN 80

                           90
                   ....*....|....*..
gi 2183974163 3167 PEYPEERQAYMLEDSGV 3183
Cdd:COG0318     81 PRLTAEELAYILEDSGA 97

FUM14_C_NRPS-like

Condensation domains of nonribosomal peptide synthetases (NRPSs) similar to the ester-bond ...

66-477

7.27e-25

Pssm-ID: 380467 [Multi-domain] Cd Length: 395 Bit Score: 110.08 E-value: 7.27e-25

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163   66 QSAAYNIPSALRLRGELDVEALSASLGAIVERHQSLRTVFVEDEQLDGFrQQVLAsvDVPVPVTLAGDDDAqaqiraFVE 145
Cdd:cd19545     18 QPGAYVGQRVFELPPDIDLARLQAAWEQVVQANPILRTRIVQSDSGGLL-QVVVK--ESPISWTESTSLDE------YLE 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  146 SETQQPFDLrNGPLLRARLLRLAADDHVLTLTIHHVAADGWSMRVLVEELIALYGARRqgieatlpdlPIQYADYAIWQR 225
Cdd:cd19545     89 EDRAAPMGL-GGPLVRLALVEDPDTERYFVWTIHHALYDGWSLPLILRQVLAAYQGEP----------VPQPPPFSRFVK 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  226 HwLEAGERERQLEYWMARLGGGQSVlelptdrQRPALPSYRG-------ARHELQLPQALGRqlqalaqreGTTLFMLLL 298
Cdd:cd19545    158 Y-LRQLDDEAAAEFWRSYLAGLDPA-------VFPPLPSSRYqprpdatLEHSISLPSSASS---------GVTLATVLR 220

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  299 ASFQALLHRYSGQDEIRVGVPVANRN----RVetERLIGFFVNTQVLRADLDAQMPFLDLLQQTRvaalgAQSHQDLPFE 374
Cdd:cd19545    221 AAWALVLSRYTGSDDVVFGVTLSGRNapvpGI--EQIVGPTIATVPLRVRIDPEQSVEDFLQTVQ-----KDLLDMIPFE 293

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  375 QLveALQPERSLS----HSPLFQAMYNHQ-NLGSAGRQSLAAQLPGLSVEDLSWGAHSaqfdLTLDTYESEQGVHAEFTY 449
Cdd:cd19545    294 HT--GLQNIRRLGpdarAACNFQTLLVVQpALPSSTSESLELGIEEESEDLEDFSSYG----LTLECQLSGSGLRVRARY 367

                          410       420
                   ....*....|....*....|....*...
gi 2183974163  450 ATDLFEAATVERLARHWRNLLEAVVAEP 477
Cdd:cd19545    368 DSSVISEEQVERLLDQFEHVLQQLASAP 395

E_NRPS

Epimerization domain of nonribosomal peptide synthetases (NRPSs); belongs to the ...

48-476

7.36e-25

Pssm-ID: 380457 [Multi-domain] Cd Length: 428 Bit Score: 110.42 E-value: 7.36e-25

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163   48 IPLSYAQerQWFLWQMDPQSAAYNIPSALRLRGELDVEALSASLGAIVERHQSLRTVFVEDEQldGFRQQVLASVDVPVP 127
Cdd:cd19534      2 VPLTPIQ--RWFFEQNLAGRHHFNQSVLLRVPQGLDPDALRQALRALVEHHDALRMRFRREDG--GWQQRIRGDVEELFR 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  128 ---VTLAGDDDAQAqIRAFVEsETQQPFDLRNGPLLRARLLRLAADDHVLTLTIHHVAADGWSMRVLVEELIALYgarRQ 204
Cdd:cd19534     78 levVDLSSLAQAAA-IEALAA-EAQSSLDLEEGPLLAAALFDGTDGGDRLLLVIHHLVVDGVSWRILLEDLEAAY---EQ 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  205 GIEATLPDLP--IQYADYAIWQRHWLEAGERERQLEYWMARLggGQSVLELPTDRQRpalpSYRGARHE-LQLPQALGRQ 281
Cdd:cd19534    153 ALAGEPIPLPskTSFQTWAELLAEYAQSPALLEELAYWRELP--AADYWGLPKDPEQ----TYGDARTVsFTLDEEETEA 226

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  282 L-QALAQREGTTLFMLLLASFQALLHRYSGQDEIRVGVPVANRNRVETE----RLIGFFVNTQVLRADLDAQMPFLDLLQ 356
Cdd:cd19534    227 LlQEANAAYRTEINDLLLAALALAFQDWTGRAPPAIFLEGHGREEIDPGldlsRTVGWFTSMYPVVLDLEASEDLGDTLK 306

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  357 QTRvAALGAQSHQDLPFEQLVEALQPERS-LSHSPLFQAMYN----HQNLGSAGrqSLAAQLPGLSVEDLSWGAH-SAQF 430
Cdd:cd19534    307 RVK-EQLRRIPNKGIGYGILRYLTPEGTKrLAFHPQPEISFNylgqFDQGERDD--ALFVSAVGGGGSDIGPDTPrFALL 383

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*.
gi 2183974163  431 DLTLDTYESEqgVHAEFTYATDLFEAATVERLARHWRNLLEAVVAE 476
Cdd:cd19534    384 DINAVVEGGQ--LVITVSYSRNMYHEETIQQLADSYKEALEALIEH 427

entE

PRK10946

(2,3-dihydroxybenzoyl)adenylate synthase;

1570-2071

8.31e-25

(2,3-dihydroxybenzoyl)adenylate synthase;

Pssm-ID: 236803 [Multi-domain] Cd Length: 536 Bit Score: 112.01 E-value: 8.31e-25

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1570 LHRLIERQAAerPRATAVVYGERALDYGELNLRANRLAHRLIELGVGP--DVLVGLAAErsLEMIVGLLAILKAGgaYVP 1647
Cdd:PRK10946    27 LTDILTRHAA--SDAIAVICGERQFSYRELNQASDNLACSLRRQGIKPgdTALVQLGNV--AEFYITFFALLKLG--VAP 100

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1648 LDPRYPSDRL---GY--------MIEDSG---------IRLLLTQ-RAARERLPLGEGLPCLLLDA-EHEWAGYPESdPQ 1705
Cdd:PRK10946   101 VNALFSHQRSelnAYasqiepalLIADRQhalfsdddfLNTLVAEhSSLRVVLLLNDDGEHSLDDAiNHPAEDFTAT-PS 179

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1706 SAvgvDNLAYVIYTSGSTGKPKgtLLP--HGNVLRLFDATRHWFGFSADD----AWSLFHSYAFdfSVWEIFGALLHGGR 1779
Cdd:PRK10946   180 PA---DEVAFFQLSGGSTGTPK--LIPrtHNDYYYSVRRSVEICGFTPQTrylcALPAAHNYPM--SSPGALGVFLAGGT 252

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1780 LVIVPyetSRSPEDFLRLLCRERVTVLNQTPSAFKQLMQVACAGQEVPPLA-LRHVVFGGEALEvqalrpwfERFGDRAP 1858
Cdd:PRK10946   253 VVLAP---DPSATLCFPLIEKHQVNVTALVPPAVSLWLQAIAEGGSRAQLAsLKLLQVGGARLS--------ETLARRIP 321

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1859 -----RLVNMYGITETTVHVTyrplSLADLDGGAASPIGEPI-PDLSWYLLDAGLNPVPRGCIGELYVGGAGLARGYLNR 1932
Cdd:PRK10946   322 aelgcQLQQVFGMAEGLVNYT----RLDDSDERIFTTQGRPMsPDDEVWVADADGNPLPQGEVGRLMTRGPYTFRGYYKS 397

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1933 PELSCTRFVADPFsttggrlYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEA--VVLPHEgp 2010
Cdd:PRK10946   398 PQHNASAFDANGF-------YCSGDLVSIDPDGYITVVGREKDQINRGGEKIAAEEIENLLLRHPAVIHAalVSMEDE-- 468

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2183974163 2011 gatqLVG-----YVVTQaAPSDPAALRDTLRQALKAslpEHMVPAHLLFLERLPLTANGKLDRRAL 2071
Cdd:PRK10946   469 ----LMGekscaFLVVK-EPLKAVQLRRFLREQGIA---EFKLPDRVECVDSLPLTAVGKVDKKQL 526

PRK06710

long-chain-fatty-acid--CoA ligase; Validated

1570-2071

8.57e-25

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 180666 [Multi-domain] Cd Length: 563 Bit Score: 112.43 E-value: 8.57e-25

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1570 LHRLIERQAAERPRATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLD 1649
Cdd:PRK06710    26 LHKYVEQMASRYPEKKALHFLGKDITFSVFHDKVKRFANYLQKLGVEKGDRVAIMLPNCPQAVIGYYGTLLAGGIVVQTN 105

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1650 PRYPSDRLGYMIEDSGIRLLL-----------TQRAAR----------ERLPLGEGL---------PCLLLDAE-----H 1694
Cdd:PRK06710   106 PLYTERELEYQLHDSGAKVILcldlvfprvtnVQSATKiehvivtriaDFLPFPKNLlypfvqkkqSNLVVKVSesetiH 185

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1695 EWAGYpESDPQSAVGV-----DNLAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRHWFGFSAD------DAWSLFHSYAF 1763
Cdd:PRK06710   186 LWNSV-EKEVNTGVEVpcdpeNDLALLQYTGGTTGFPKGVMLTHKNLVSNTLMGVQWLYNCKEgeevvlGVLPFFHVYGM 264

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1764 DfSVWEIfgALLHGGRLVIVPYETSRSPEDFLRllcRERVTVLNQTPSAFKQLMQVACAgQEVPPLALRHVVFGGEALEV 1843
Cdd:PRK06710   265 T-AVMNL--SIMQGYKMVLIPKFDMKMVFEAIK---KHKVTLFPGAPTIYIALLNSPLL-KEYDISSIRACISGSAPLPV 337

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1844 QaLRPWFERFgdRAPRLVNMYGITETTvhvtyrPLSLADL--DGGAASPIGEPIPDLSWYL--LDAGlNPVPRGCIGELY 1919
Cdd:PRK06710   338 E-VQEKFETV--TGGKLVEGYGLTESS------PVTHSNFlwEKRVPGSIGVPWPDTEAMImsLETG-EALPPGEIGEIV 407

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1920 VGGAGLARGYLNRPELSCTRFvadpfstTGGRLYrTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGV 1999
Cdd:PRK06710   408 VKGPQIMKGYWNKPEETAAVL-------QDGWLH-TGDVGYMDEDGFFYVKDRKKDMIVASGFNVYPREVEEVLYEHEKV 479

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2183974163 2000 AEAVVLPHEGPGATQLV-GYVVTQaapSDPAALRDTLRQALKASLPEHMVPAHLLFLERLPLTANGKLDRRAL 2071
Cdd:PRK06710   480 QEVVTIGVPDPYRGETVkAFVVLK---EGTECSEEELNQFARKYLAAYKVPKVYEFRDELPKTTVGKILRRVL 549

PLN02246

4-coumarate--CoA ligase

488-953

1.18e-24

4-coumarate--CoA ligase

Pssm-ID: 215137 [Multi-domain] Cd Length: 537 Bit Score: 111.61 E-value: 1.18e-24

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  488 DAEERATLLQRSRLPASEYPAGQGVHR-LFEAQAGLtPDAPALLFGE--ERLSYAELNALANRLAWRLREEGVGSDVLVG 564
Cdd:PLN02246     1 EASASEEFIFRSKLPDIYIPNHLPLHDyCFERLSEF-SDRPCLIDGAtgRVYTYADVELLSRRVAAGLHKLGIRQGDVVM 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  565 IALERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQYMIDDSGLRLLLSQQSV---LARLPQSDGLQSLLLDDL-ERLVH 640
Cdd:PLN02246    80 LLLPNCPEFVLAFLGASRRGAVTTTANPFYTPAEIAKQAKASGAKLIITQSCYvdkLKGLAEDDGVTVVTIDDPpEGCLH 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  641 GYP---AENPDLPEA---PDSLCYAIYTSGSTGQPKGVMVRHRALtnfVCSIARQ-----P--GMLARDRLLSVTTFsFD 707
Cdd:PLN02246   160 FSEltqADENELPEVeisPDDVVALPYSSGTTGLPKGVMLTHKGL---VTSVAQQvdgenPnlYFHSDDVILCVLPM-FH 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  708 IFGLE--LYVPLARGASMLLASReqaQDPEALLDLVERQGVTVLQATPATWRMLCDSERV---DLLRGCTLLCGGEALAE 782
Cdd:PLN02246   236 IYSLNsvLLCGLRVGAAILIMPK---FEIGALLELIQRHKVTIAPFVPPIVLAIAKSPVVekyDLSSIRMVLSGAAPLGK 312

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  783 DL--AARMRGLSASTWNLYGPTET-TIWSARFRLGEEarPF------LGGPLENTALYILDSEMN-PCPPGVAGELLIGG 852
Cdd:PLN02246   313 ELedAFRAKLPNAVLGQGYGMTEAgPVLAMCLAFAKE--PFpvksgsCGTVVRNAELKIVDPETGaSLPRNQPGEICIRG 390

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  853 DGLARGYHRRPGLTAErflpdpfAADGSRLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREA 932
Cdd:PLN02246   391 PQIMKGYLNDPEATAN-------TIDKDGWLHTGDIGYIDDDDELFIVDRLKELIKYKGFQVAPAELEALLISHPSIADA 463

                          490       500
                   ....*....|....*....|..
gi 2183974163  933 VVVAQPG-VAGPTLVAYLVPTE 953
Cdd:PLN02246   464 AVVPMKDeVAGEVPVAFVVRSN 485

PRK13383

acyl-CoA synthetase; Provisional

1527-2073

1.35e-24

acyl-CoA synthetase; Provisional

Pssm-ID: 139531 [Multi-domain] Cd Length: 516 Bit Score: 111.24 E-value: 1.35e-24

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1527 LLRSIVARPEARIAELKLLDEAearadllqWNPGPQDFTPASClhrlierQAAERPRATAVVYGERALDYGELNLRANRL 1606
Cdd:PRK13383     9 LVRSGLLNPPSPRAVLRLLREA--------SRGGTNPYTLLAV-------TAARWPGRTAIIDDDGALSYRELQRATESL 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1607 AHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGYMIEDSGIRLLLTQRAARERLPlGEGLP 1686
Cdd:PRK13383    74 ARRLTRDGVAPGRAVGVMCRNGRGFVTAVFAVGLLGADVVPISTEFRSDALAAALRAHHISTVVADNEFAERIA-GADDA 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1687 CLLLDAEHewAGYPESDPQSAVGVDNlAYVIYTSGSTGKPKGtlLPHGNVLR--------LFDATRHWFGFSADDAWSLF 1758
Cdd:PRK13383   153 VAVIDPAT--AGAEESGGRPAVAAPG-RIVLLTSGTTGKPKG--VPRAPQLRsavgvwvtILDRTRLRTGSRISVAMPMF 227

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1759 HSYAFDFSVWEIfgALlhGGRLVivpyeTSR--SPEDFLRLLCRERVTVLNQTPSAFKQLMQVACAGQEVPPL-ALRHVV 1835
Cdd:PRK13383   228 HGLGLGMLMLTI--AL--GGTVL-----THRhfDAEAALAQASLHRADAFTAVPVVLARILELPPRVRARNPLpQLRVVM 298

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1836 FGGEALEVQALRPWFERFGDrapRLVNMYGITETTVHVTYRPLSLADldggAASPIGEPIPDLSWYLLDAGLNPVPRGCI 1915
Cdd:PRK13383   299 SSGDRLDPTLGQRFMDTYGD---ILYNGYGSTEVGIGALATPADLRD----APETVGKPVAGCPVRILDRNNRPVGPRVT 371

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1916 GELYVGGaglargylnrpELSCTRfvadpFSTTGGR-----LYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIE 1990
Cdd:PRK13383   372 GRIFVGG-----------ELAGTR-----YTDGGGKavvdgMTSTGDMGYLDNAGRLFIVGREDDMIISGGENVYPRAVE 435

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1991 ARLLAQPGVAEAVVL--PHEGPGaTQLVGYVVTQAAPS-DPAALRDTlrqaLKASLPEHMVPAHLLFLERLPLTANGKLD 2067
Cdd:PRK13383   436 NALAAHPAVADNAVIgvPDERFG-HRLAAFVVLHPGSGvDAAQLRDY----LKDRVSRFEQPRDINIVSSIPRNPTGKVL 510


                   ....*.
gi 2183974163 2068 RRALPA 2073
Cdd:PRK13383   511 RKELPG 516

A_NRPS_ACVS-like

cd17648

N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase; This family contains ACV ...

3099-3182

1.37e-24

Pssm-ID: 341303 [Multi-domain] Cd Length: 453 Bit Score: 110.18 E-value: 1.37e-24

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3099 PTAPALAFGEERLDYAELNRRANRLAHALIERGIG-ADRLVGVAMERSIEMVVALMAILKAGGAYVPVDPEYPEERQAYM 3177
Cdd:cd17648      1 PDRVAVVYGDKRLTYRELNERANRLAHYLLSVAEIrPDDLVGLVLDKSELMIIAILAVWKAGAAYVPIDPSYPDERIQFI 80


                   ....*
gi 2183974163 3178 LEDSG 3182
Cdd:cd17648     81 LEDTG 85

LC_FACS_like

cd17640

Long-chain fatty acid CoA synthetase; This family includes long-chain fatty acid (C12-C20) CoA ...

1590-2008

1.53e-24

Pssm-ID: 341295 [Multi-domain] Cd Length: 468 Bit Score: 110.14 E-value: 1.53e-24

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1590 GERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGYMIEDSGIRLL 1669
Cdd:cd17640      2 PPKRITYKDLYQEILDFAAGLRSLGVKAGEKVALFADNSPRWLIADQGIMALGAVDVVRGSDSSVEELLYILNHSESVAL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1670 LTqraarerlplgeglpcllldaehewagypESDPqsavgvDNLAYVIYTSGSTGKPKGTLLPHGNVLrlfdatrhwfgF 1749
Cdd:cd17640     82 VV-----------------------------ENDS------DDLATIIYTSGTTGNPKGVMLTHANLL-----------H 115

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1750 SADDAWSLFHSYAFDFSV-----WEIFG------ALLHGGRLVivpYETSRS-PEDFLRLlcreRVTVLNQTP------- 1810
Cdd:cd17640    116 QIRSLSDIVPPQPGDRFLsilpiWHSYErsaeyfIFACGCSQA---YTSIRTlKDDLKRV----KPHYIVSVPrlwesly 188

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1811 ----------SAFKQ-LMQVACAGQEvpplaLRHVVFGGEALeVQALRPWFERFGdraPRLVNMYGITETTVHVTYRpls 1879
Cdd:cd17640    189 sgiqkqvsksSPIKQfLFLFFLSGGI-----FKFGISGGGAL-PPHVDTFFEAIG---IEVLNGYGLTETSPVVSAR--- 256

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1880 laDLDGGAASPIGEPIPDLSWYLLDA-GLNPVPRGCIGELYVGGAGLARGYLNRPELSCTRFVADPFsttggrlYRTGDL 1958
Cdd:cd17640    257 --RLKCNVRGSVGRPLPGTEIKIVDPeGNVVLPPGEKGIVWVRGPQVMKGYYKNPEATSKVLDSDGW-------FNTGDL 327

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2183974163 1959 ARYRCDGVVEYVGRI-DHQVKIRGFRIELGEIEARLLAQPGVAEAVVLPHE 2008
Cdd:cd17640    328 GWLTCGGELVLTGRAkDTIVLSNGENVEPQPIEEALMRSPFIEQIMVVGQD 378

LC_FACL_like

cd05914

Uncharacterized subfamily of fatty acid CoA ligase (FACL); The members of this family are ...

529-1004

3.04e-24

Uncharacterized subfamily of fatty acid CoA ligase (FACL); The members of this family are bacterial long-chain fatty acid CoA synthetase, most of which are as yet uncharacterized. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.

Pssm-ID: 341240 [Multi-domain] Cd Length: 463 Bit Score: 109.45 E-value: 3.04e-24

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  529 LLFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQYMIDDSGL 608
Cdd:cd05914      1 LYYGGEPLTYKDLADNIAKFALLLKINGVGTGDRVALMGENRPEWGIAFFAIWTYGAIAVPILAEFTADEVHHILNHSEA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  609 RLLLSqqsvlarlpqSDglqslllddlerlvhgypaenpdlpeaPDSLCYAIYTSGSTGQPKGVMVRHRALTNFVCSIAR 688
Cdd:cd05914     81 KAIFV----------SD---------------------------EDDVALINYTSGTTGNSKGVMLTYRNIVSNVDGVKE 123

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  689 QPGMLARDRLLSVTTFSfDIFGL--ELYVPLARGASMLLASREqaqdPEALLDLVERQGVTVLQATPATWRML-----CD 761
Cdd:cd05914    124 VVLLGKGDKILSILPLH-HIYPLtfTLLLPLLNGAHVVFLDKI----PSAKIIALAFAQVTPTLGVPVPLVIEkifkmDI 198

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  762 SERVDLLRGCTLL-----------------------------CGGEALAEDLAARMRGLSASTWNLYGPTET------TI 806
Cdd:cd05914    199 IPKLTLKKFKFKLakkinnrkirklafkkvheafggnikefvIGGAKINPDVEEFLRTIGFPYTIGYGMTETapiisySP 278

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  807 WsARFRLGEearpfLGGPLENTALYILDsemnPCPPGVAGELLIGGDGLARGYHRRPGLTAERFLPDPFaadgsrlYRTG 886
Cdd:cd05914    279 P-NRIRLGS-----AGKVIDGVEVRIDS----PDPATGEGEIIVRGPNVMKGYYKNPEATAEAFDKDGW-------FHTG 341

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  887 DLARYRADGVIEYLGRIDHQ-VKIRGFRIELGEIETRLLEQDSVREAVVVAQPGvagpTLVAYLVPtEAALVDAESARQQ 965
Cdd:cd05914    342 DLGKIDAEGYLYIRGRKKEMiVLSSGKNIYPEEIEAKINNMPFVLESLVVVQEK----KLVALAYI-DPDFLDVKALKQR 416

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....
gi 2183974163  966 ELRSALKNSLL----AVLPDY-MVPAHMLLLENLPLTPNGKINR 1004
Cdd:cd05914    417 NIIDAIKWEVRdkvnQKVPNYkKISKVKIVKEEFEKTPKGKIKR 460

ACLS-CaiC

cd17637

acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; This family contains fatty acid CoA ...

1716-2068

3.14e-24

acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; This family contains fatty acid CoA ligases, including acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II, most of which are yet to be characterized, but may be similar to Carnitine-CoA ligase (CaiC) which catalyzes the transfer of CoA to carnitine. Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.

Pssm-ID: 341292 [Multi-domain] Cd Length: 333 Bit Score: 106.59 E-value: 3.14e-24

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1716 VIYTSGSTGKPKGTLLPHGNVLRLFDATRHWFGFSADDAW----SLFHSYAFDFSVweifgALLH-GGRLVIVPyetSRS 1790
Cdd:cd17637      5 IIHTAAVAGRPRGAVLSHGNLIAANLQLIHAMGLTEADVYlnmlPLFHIAGLNLAL-----ATFHaGGANVVME---KFD 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1791 PEDFLRLLCRERVTVLNQTPSAFKQLMQVAcAGQEVPPLALRHVvFGGEALEVqalrpwFERFGDRAP-RLVNMYGITET 1869
Cdd:cd17637     77 PAEALELIEEEKVTLMGSFPPILSNLLDAA-EKSGVDLSSLRHV-LGLDAPET------IQRFEETTGaTFWSLYGQTET 148

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1870 TVHVTYRPLSlaDLDGGAaspiGEPIPDLSWYLLDAGLNPVPRGCIGELYVGGAGLARGYLNRPELSCTrfvadpfsTTG 1949
Cdd:cd17637    149 SGLVTLSPYR--ERPGSA----GRPGPLVRVRIVDDNDRPVPAGETGEIVVRGPLVFQGYWNLPELTAY--------TFR 214

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1950 GRLYRTGDLARYRCDGVVEYVGRIDHQ--VKIRGFRIELGEIEARLLAQPGVAEAVVLPHEGPGATQLVGYVVTQAAPSD 2027
Cdd:cd17637    215 NGWHHTGDLGRFDEDGYLWYAGRKPEKelIKPGGENVYPAEVEKVILEHPAIAEVCVIGVPDPKWGEGIKAVCVLKPGAT 294

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|.
gi 2183974163 2028 PAAlrDTLRQALKASLPEHMVPAHLLFLERLPLTANGKLDR 2068
Cdd:cd17637    295 LTA--DELIEFVGSRIARYKKPRYVVFVEALPKTADGSIDR 333

DCL_NRPS-like

DCL-type Condensation domains of nonribosomal peptide synthetases (NRPSs), such as terminal ...

2174-2598

3.66e-24

Pssm-ID: 380459 [Multi-domain] Cd Length: 419 Bit Score: 108.31 E-value: 3.66e-24

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2174 PLLPIQQ--MFFELDIPRRQHWNQSVLLEPGQALDGTLLETALQALLAHHDALRLGFRLEDG----TWRAEHRAVEAGEV 2247
Cdd:cd19536      3 PLSSLQEgmLFHSLLNPGGSVYLHNYTYTVGRRLNLDLLLEALQVLIDRHDILRTSFIEDGLgqpvQVVHRQAQVPVTEL 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2248 LLWQQSVADGQALEALAEQVQRSLDLGSGPLLRALLATLgDGSQRLLLVI--HHLVVDGVSWRILLEDLQTAYRQLQAGQ 2325
Cdd:cd19536     83 DLTPLEEQLDPLRAYKEETKIRRFDLGRAPLVRAALVRK-DERERFLLVIsdHHSILDGWSLYLLVKEILAVYNQLLEYK 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2326 AVALPaKTSAFKAWAERLQAHARDGGLEgerGYWLAQLEGVSTELPCDDREGAQSVRHVRSARTELTEEATRrllqEAPA 2405
Cdd:cd19536    162 PLSLP-PAQPYRDFVAHERASIQQAASE---RYWREYLAGATLATLPALSEAVGGGPEQDSELLVSVPLPVR----SRSL 233

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2406 AYRTQVN--DLLLTALARVIGRWTGQADTLIQLEGHGREELFEDIDltRTVGWFTSLFPLRLS-PVAELGASIKRIKEQL 2482
Cdd:cd19536    234 AKRSGIPlsTLLLAAWALVLSRHSGSDDVVFGTVVHGRSEETTGAE--RLLGLFLNTLPLRVTlSEETVEDLLKRAQEQE 311

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2483 R-AIPHKGLGFGALRYLGSAEdraalaalpsPRIT--FNYLgQFDGSFSADS-SALFRPSADAAGSERDSDAPLdnWLSL 2558
Cdd:cd19536    312 LeSLSHEQVPLADIQRCSEGE----------PLFDsiVNFR-HFDLDFGLPEwGSDEGMRRGLLFSEFKSNYDV--NLSV 378

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|
gi 2183974163 2559 NGQvyAGRLGIDWSFSAARFSEASILRLADAYRDELLALI 2598
Cdd:cd19536    379 LPK--QDRLELKLAYNSQVLDEEQAQRLAAYYKSAIAELA 416

PRK13391

acyl-CoA synthetase; Provisional

520-1007

6.28e-24

acyl-CoA synthetase; Provisional

Pssm-ID: 184022 [Multi-domain] Cd Length: 511 Bit Score: 109.01 E-value: 6.28e-24

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  520 AGLTPDAPALLFGE--ERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPAD 597
Cdd:PRK13391     7 AQTTPDKPAVIMAStgEVVTYRELDERSNRLAHLFRSLGLKRGDHVAIFMENNLRYLEVCWAAERSGLYYTCVNSHLTPA 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  598 RLQYMIDDSGLRLLLS---QQSVLARLPQS--DGLQSLLLD---DLERLVhGYPAENPDLPEAP---DSLCYAI-YTSGS 665
Cdd:PRK13391    87 EAAYIVDDSGARALITsaaKLDVARALLKQcpGVRHRLVLDgdgELEGFV-GYAEAVAGLPATPiadESLGTDMlYSSGT 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  666 TGQPKGVMvrhraltnfvcsiaRQPGMLARDRLLSVTTFSFDIFGLE----------LY--VPLArgASMLLASR----- 728
Cdd:PRK13391   166 TGRPKGIK--------------RPLPEQPPDTPLPLTAFLQRLWGFRsdmvylspapLYhsAPQR--AVMLVIRLggtvi 229

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  729 -EQAQDPEALLDLVERQGVTVLQATPATW-RMLCDSERV----DLlrgCTLLCGGEALA---EDLAARM-RGLSASTWNL 798
Cdd:PRK13391   230 vMEHFDAEQYLALIEEYGVTHTQLVPTMFsRMLKLPEEVrdkyDL---SSLEVAIHAAApcpPQVKEQMiDWWGPIIHEY 306

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  799 YGPTE----TTIWSARF--RLGEEARPFLGgplentALYILDSEMNPCPPGVAGELLIGGdGLARGYHRRPGLTAERFLP 872
Cdd:PRK13391   307 YAATEglgfTACDSEEWlaHPGTVGRAMFG------DLHILDDDGAELPPGEPGTIWFEG-GRPFEYLNDPAKTAEARHP 379

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  873 DPfaadgsRLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQPGVA-GPTLVAYLVP 951
Cdd:PRK13391   380 DG------TWSTVGDIGYVDEDGYLYLTDRAAFMIISGGVNIYPQEAENLLITHPKVADAAVFGVPNEDlGEEVKAVVQP 453

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2183974163  952 TEAalVDAESARQQELRSALKNSLLAvlpdYMVPAHMLLLENLPLTPNGKINRKAL 1007
Cdd:PRK13391   454 VDG--VDPGPALAAELIAFCRQRLSR----QKCPRSIDFEDELPRLPTGKLYKRLL 503

PRK07638

acyl-CoA synthetase; Validated

520-1007

8.83e-24

acyl-CoA synthetase; Validated

Pssm-ID: 236071 [Multi-domain] Cd Length: 487 Bit Score: 108.33 E-value: 8.83e-24

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  520 AGLTPDAPALLFGEERLSYAELNALANRLAWRLREEGvGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRL 599
Cdd:PRK07638    11 ASLQPNKIAIKENDRVLTYKDWFESVCKVANWLNEKE-SKNKTIAILLENRIEFLQLFAGAAMAGWTCVPLDIKWKQDEL 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  600 QYMIDDSGLRLLLSQQSVLARLPQSDGlQSLLLDDLERLVHGY---PAENPDLPEAPdslCYAIYTSGSTGQPKGVMVRH 676
Cdd:PRK07638    90 KERLAISNADMIVTERYKLNDLPDEEG-RVIEIDEWKRMIEKYlptYAPIENVQNAP---FYMGFTSGSTGKPKAFLRAQ 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  677 RA-LTNFVCSiARQPGMLARDRLLSVTTF--SFDIFGL--ELYVplarGASMLLasrEQAQDPEALLDLVERQGVTVLQA 751
Cdd:PRK07638   166 QSwLHSFDCN-VHDFHMKREDSVLIAGTLvhSLFLYGAisTLYV----GQTVHL---MRKFIPNQVLDKLETENISVMYT 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  752 TPATWRMLCDSERVdLLRGCTLLCGG---EALAEDlAARMRGLSASTWNLYGPTETTIWSARFRLGEEARP-FLGGPLEN 827
Cdd:PRK07638   238 VPTMLESLYKENRV-IENKMKIISSGakwEAEAKE-KIKNIFPYAKLYEFYGASELSFVTALVDEESERRPnSVGRPFHN 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  828 TALYILDSEMNPCPPGVAGELLIGGDGLARGYhrrpglTAERFLPDPFAADGsrlYRT-GDLARYRADGVIEYLGRIDHQ 906
Cdd:PRK07638   316 VQVRICNEAGEEVQKGEIGTVYVKSPQFFMGY------IIGGVLARELNADG---WMTvRDVGYEDEEGFIYIVGREKNM 386

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  907 VKIRGFRIELGEIETRLLEQDSVREAVVVaqpGVAGPtlvaYLVPTEAALVDAeSARQQELRSALKNSllavLPDYMVPA 986
Cdd:PRK07638   387 ILFGGINIFPEEIESVLHEHPAVDEIVVI---GVPDS----YWGEKPVAIIKG-SATKQQLKSFCLQR----LSSFKIPK 454

                          490       500
                   ....*....|....*....|.
gi 2183974163  987 HMLLLENLPLTPNGKINRKAL 1007
Cdd:PRK07638   455 EWHFVDEIPYTNSGKIARMEA 475

OSB_CoA_lg

cd05912

O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA ...

536-1007

9.93e-24

Pssm-ID: 341238 [Multi-domain] Cd Length: 411 Bit Score: 107.05 E-value: 9.93e-24

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  536 LSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQYMIDDSGLRLllsqq 615
Cdd:cd05912      2 YTFAELFEEVSRLAEHLAALGVRKGDRVALLSKNSIEMILLIHALWLLGAEAVLLNTRLTPNELAFQLKDSDVKL----- 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  616 svlarlpqsdglqslllddlerlvhgypaenpdlpeapDSLCYAIYTSGSTGQPKGVMVRHRALTNFVCSIARQPGMLAR 695
Cdd:cd05912     77 --------------------------------------DDIATIMYTSGTTGKPKGVQQTFGNHWWSAIGSALNLGLTED 118

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  696 DRLLSVTTFsFDIFGLELYV-PLARGASMLLasrEQAQDPEALLDLVERQGVTVLQATPATWRMLCDservDLLRGC--- 771
Cdd:cd05912    119 DNWLCALPL-FHISGLSILMrSVIYGMTVYL---VDKFDAEQVLHLINSGKVTIISVVPTMLQRLLE----ILGEGYpnn 190

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  772 --TLLCGGEALAEDLAARMRGLSASTWNLYGPTET-------TIWSARFRLGEearpfLGGPLENTALYILDSEMnpcPP 842
Cdd:cd05912    191 lrCILLGGGPAPKPLLEQCKEKGIPVYQSYGMTETcsqivtlSPEDALNKIGS-----AGKPLFPVELKIEDDGQ---PP 262

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  843 GVAGELLIGGDGLARGYHRRPGLTAERFLPDPFaadgsrlyRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETR 922
Cdd:cd05912    263 YEVGEILLKGPNVTKGYLNRPDATEESFENGWF--------KTGDIGYLDEEGFLYVLDRRSDLIISGGENIYPAEIEEV 334

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  923 LLEQDSVREAVVVAQPGVA-GPTLVAYLVpteaalvdaesaRQQELRSA-LKNSLLAVLPDYMVPAHMLLLENLPLTPNG 1000
Cdd:cd05912    335 LLSHPAIKEAGVVGIPDDKwGQVPVAFVV------------SERPISEEeLIAYCSEKLAKYKVPKKIYFVDELPRTASG 402


                   ....*..
gi 2183974163 1001 KINRKAL 1007
Cdd:cd05912    403 KLLRHEL 409

caiC

PRK08008

putative crotonobetaine/carnitine-CoA ligase; Validated

1585-2071

1.34e-23

putative crotonobetaine/carnitine-CoA ligase; Validated

Pssm-ID: 181195 [Multi-domain] Cd Length: 517 Bit Score: 107.85 E-value: 1.34e-23

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1585 TAVVYGERALD-----YGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGY 1659
Cdd:PRK08008    24 TALIFESSGGVvrrysYLELNEEINRTANLFYSLGIRKGDKVALHLDNCPEFIFCWFGLAKIGAIMVPINARLLREESAW 103

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1660 MIEDSGIRLLLTQRAA---------------RERLPLGEGLPCL-------LLDAEHEwagyPESDPQSAVGVDNLAYVI 1717
Cdd:PRK08008   104 ILQNSQASLLVTSAQFypmyrqiqqedatplRHICLTRVALPADdgvssftQLKAQQP----ATLCYAPPLSTDDTAEIL 179

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1718 YTSGSTGKPKGTLLPHGNvLRLFDATRHWFG-FSADDAW-SLFHSYAFDFSVWEIFGALLHGGRLVIVPYETSRSpedFL 1795
Cdd:PRK08008   180 FTSGTTSRPKGVVITHYN-LRFAGYYSAWQCaLRDDDVYlTVMPAFHIDCQCTAAMAAFSAGATFVLLEKYSARA---FW 255

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1796 RLLCRERVTVLNQTPSAFKQLM-QVACAGQEvpPLALRHVVFgGEALEVQALRPWFERFGdraPRLVNMYGITETTVHVt 1874
Cdd:PRK08008   256 GQVCKYRATITECIPMMIRTLMvQPPSANDR--QHCLREVMF-YLNLSDQEKDAFEERFG---VRLLTSYGMTETIVGI- 328

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1875 yrplsLADLDGGAAS--PIGEPIPDLSWYLLDAGLNPVPRGCIGELYVGG-AG--LARGYLNRPELSCTRFVADpfsttg 1949
Cdd:PRK08008   329 -----IGDRPGDKRRwpSIGRPGFCYEAEIRDDHNRPLPAGEIGEICIKGvPGktIFKEYYLDPKATAKVLEAD------ 397

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1950 GRLYrTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVVlphegpgatqlVGYvvtqaapsdPA 2029
Cdd:PRK08008   398 GWLH-TGDTGYVDEEGFFYFVDRRCNMIKRGGENVSCVELENIIATHPKIQDIVV-----------VGI---------KD 456

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2183974163 2030 ALRDtlrQALKA--------SLPE---------HM----VPAHLLFLERLPLTANGKLDRRAL 2071
Cdd:PRK08008   457 SIRD---EAIKAfvvlnegeTLSEeeffafceqNMakfkVPSYLEIRKDLPRNCSGKIIKKNL 516

PRK12492

long-chain-fatty-acid--CoA ligase; Provisional

1707-2071

1.44e-23

long-chain-fatty-acid--CoA ligase; Provisional

Pssm-ID: 171539 [Multi-domain] Cd Length: 562 Bit Score: 108.37 E-value: 1.44e-23

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1707 AVGVDNLAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRHWFGFSADDAWSLF--------------HSYAFDFSVweiFG 1772
Cdd:PRK12492   203 PVGLDDIAVLQYTGGTTGLAKGAMLTHGNLVANMLQVRACLSQLGPDGQPLMkegqevmiaplplyHIYAFTANC---MC 279

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1773 ALLHGGRLVIVPyetsrSPED---FLRLLCRERVTVLNQTPSAFKQLMQVAcAGQEVPPLALRHVVFGGEALEVQALRPW 1849
Cdd:PRK12492   280 MMVSGNHNVLIT-----NPRDipgFIKELGKWRFSALLGLNTLFVALMDHP-GFKDLDFSALKLTNSGGTALVKATAERW 353

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1850 FERFGdraPRLVNMYGITETTVHVTYRPL-SLADLdggaaSPIGEPIPDLSWYLLDAGLNPVPRGCIGELYVGGAGLARG 1928
Cdd:PRK12492   354 EQLTG---CTIVEGYGLTETSPVASTNPYgELARL-----GTVGIPVPGTALKVIDDDGNELPLGERGELCIKGPQVMKG 425

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1929 YLNRPELSCTRFVADPFsttggrlYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAE--AVVLP 2006
Cdd:PRK12492   426 YWQQPEATAEALDAEGW-------FKTGDIAVIDPDGFVRIVDRKKDLIIVSGFNVYPNEIEDVVMAHPKVANcaAIGVP 498

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2183974163 2007 HEGPG-ATQLvgYVVtqaaPSDPAALRDTLRQALKASLPEHMVPAHLLFLERLPLTANGKLDRRAL 2071
Cdd:PRK12492   499 DERSGeAVKL--FVV----ARDPGLSVEELKAYCKENFTGYKVPKHIVLRDSLPMTPVGKILRREL 558

FACL_like_4

cd05944

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ...

1711-2078

1.72e-23

Pssm-ID: 341266 [Multi-domain] Cd Length: 359 Bit Score: 105.26 E-value: 1.72e-23

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1711 DNLAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRHWFGFSADD----AWSLFHSyafdFSVWEIFGALLHGGRLVIVP-- 1784
Cdd:cd05944      2 DDVAAYFHTGGTTGTPKLAQHTHSNEVYNAWMLALNSLFDPDDvllcGLPLFHV----NGSVVTLLTPLASGAHVVLAgp 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1785 --YETSRSPEDFLRLLCRERVTVLNQTPSAFKQLMQVAcAGQEVPplALRHVVFGGEALEVQAlrpwFERFGDRAP-RLV 1861
Cdd:cd05944     78 agYRNPGLFDNFWKLVERYRITSLSTVPTVYAALLQVP-VNADIS--SLRFAMSGAAPLPVEL----RARFEDATGlPVV 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1862 NMYGITETTVHVTYRPlsladlDGGAASP--IGEPIP----------DLSWYLLDAGLNPVprgciGELYVGGAGLARGY 1929
Cdd:cd05944    151 EGYGLTEATCLVAVNP------PDGPKRPgsVGLRLPyarvrikvldGVGRLLRDCAPDEV-----GEICVAGPGVFGGY 219

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1930 LNRpELSCTRFVADPFsttggrlYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVVLPHEG 2009
Cdd:cd05944    220 LYT-EGNKNAFVADGW-------LNTGDLGRLDADGYLFITGRAKDLIIRGGHNIDPALIEEALLRHPAVAFAGAVGQPD 291

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2183974163 2010 PGATQL-VGYV-VTQAAPSDPAALRDTLRqalkASLPEHM-VPAHLLFLERLPLTANGKLDRRALPAPDASR 2078
Cdd:cd05944    292 AHAGELpVAYVqLKPGAVVEEEELLAWAR----DHVPERAaVPKHIEVLEELPVTAVGKVFKPALRADAIHR 359

ttLC_FACS_AEE21_like

cd12118

Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; This ...

1565-2065

1.75e-23

Pssm-ID: 341283 [Multi-domain] Cd Length: 486 Bit Score: 107.38 E-value: 1.75e-23

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1565 TPASclhrLIERQAAERPRATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGA 1644
Cdd:cd12118      5 TPLS----FLERAAAVYPDRTSIVYGDRRYTWRQTYDRCRRLASALAALGISRGDTVAVLAPNTPAMYELHFGVPMAGAV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1645 YVPLDPRYPSDRLGYMIEDSGIRLLLTqraarerlplgeglpclllDAEHEW-----AGYPESDPQSAVGVDNLAYVIYT 1719
Cdd:cd12118     81 LNALNTRLDAEEIAFILRHSEAKVLFV-------------------DREFEYedllaEGDPDFEWIPPADEWDPIALNYT 141

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1720 SGSTGKPKGTLLPH-GNVLRLFDATRHW-FGFSADDAWSL--FHSYAFDFsVWEIFGAllhGGRLVIVPyeTSRSPEDFl 1795
Cdd:cd12118    142 SGTTGRPKGVVYHHrGAYLNALANILEWeMKQHPVYLWTLpmFHCNGWCF-PWTVAAV---GGTNVCLR--KVDAKAIY- 214

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1796 RLLCRERVT-------VLN-------QTPSAFKQLMQVACAGqeVPPLAlrHVVFGGEALEVqalrpwferfgdrapRLV 1861
Cdd:cd12118    215 DLIEKHKVThfcgaptVLNmlanappSDARPLPHRVHVMTAG--APPPA--AVLAKMEELGF---------------DVT 275

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1862 NMYGITETTVHVT---YRP----LSLADLDG-----GAASPIGEPIPdlswyLLDA-GLNPVPRG--CIGELYVGGAGLA 1926
Cdd:cd12118    276 HVYGLTETYGPATvcaWKPewdeLPTEERARlkarqGVRYVGLEEVD-----VLDPeTMKPVPRDgkTIGEIVFRGNIVM 350

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1927 RGYLNRPElsctrfvADPFSTTGGrLYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVVL- 2005
Cdd:cd12118    351 KGYLKNPE-------ATAEAFRGG-WFHSGDLAVIHPDGYIEIKDRSKDIIISGGENISSVEVEGVLYKHPAVLEAAVVa 422

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2183974163 2006 -PHEGPGATqLVGYVVTQAAPSdpaALRDTLRQALKASLPEHMVPAHLLFLErLPLTANGK 2065
Cdd:cd12118    423 rPDEKWGEV-PCAFVELKEGAK---VTEEEIIAFCREHLAGFMVPKTVVFGE-LPKTSTGK 478

PRK07867

acyl-CoA synthetase; Validated

507-1007

3.27e-23

acyl-CoA synthetase; Validated

Pssm-ID: 236120 [Multi-domain] Cd Length: 529 Bit Score: 107.07 E-value: 3.27e-23

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  507 PAGQGVHRLFEAQAGLtpDAPALLFGEERLSYAELNALANRLAWRLREE-GVGSDVLVGIALERGVPMVVALLAVLKAGG 585
Cdd:PRK07867     2 SSAPTVAELLLPLAED--DDRGLYFEDSFTSWREHIRGSAARAAALRARlDPTRPPHVGVLLDNTPEFSLLLGAAALSGI 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  586 AYVPLDPQYPADRLQYMIDDSGLRLLLSQQSVLARLPQSDGLQSLLLDDLER---LVHGYPAENPDLPEA-PDSLCYAIY 661
Cdd:PRK07867    80 VPVGLNPTRRGAALARDIAHADCQLVLTESAHAELLDGLDPGVRVINVDSPAwadELAAHRDAEPPFRVAdPDDLFMLIF 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  662 TSGSTGQPKGVMVRHRALTNFVCSIARQPGMLARD-RLLSVTTFSFDIFGLELYVPLARGASMLLASREQAQdpeALLDL 740
Cdd:PRK07867   160 TSGTSGDPKAVRCTHRKVASAGVMLAQRFGLGPDDvCYVSMPLFHSNAVMAGWAVALAAGASIALRRKFSAS---GFLPD 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  741 VERQGVT-----------VLqATPatwrmlcdsERVD----LLRgctLLCGGEALAEDLAARMRGLSASTWNLYGPTETT 805
Cdd:PRK07867   237 VRRYGATyanyvgkplsyVL-ATP---------ERPDdadnPLR---IVYGNEGAPGDIARFARRFGCVVVDGFGSTEGG 303

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  806 IWSARfrlgEEARP--FLGGPLENTAlyILDSEM-NPCPPGVA------------GELL-IGGDGLARGYHRRPGLTAER 869
Cdd:PRK07867   304 VAITR----TPDTPpgALGPLPPGVA--IVDPDTgTECPPAEDadgrllnadeaiGELVnTAGPGGFEGYYNDPEADAER 377

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  870 flpdpfAADGsrLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQPG-VAGPTLVAY 948
Cdd:PRK07867   378 ------MRGG--VYWSGDLAYRDADGYAYFAGRLGDWMRVDGENLGTAPIERILLRYPDATEVAVYAVPDpVVGDQVMAA 449

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2183974163  949 LVPTEAALVDAESARQQelrsalknslLAVLPDY---MVPAHMLLLENLPLTPNGKINRKAL 1007
Cdd:PRK07867   450 LVLAPGAKFDPDAFAEF----------LAAQPDLgpkQWPSYVRVCAELPRTATFKVLKRQL 501

PRK07867

acyl-CoA synthetase; Validated

1621-2073

3.80e-23

acyl-CoA synthetase; Validated

Pssm-ID: 236120 [Multi-domain] Cd Length: 529 Bit Score: 106.69 E-value: 3.80e-23

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1621 VGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGYMIEDSGIRLLLTQRAARERL-PLGEGLPCLLLDAEH---EW 1696
Cdd:PRK07867    57 VGVLLDNTPEFSLLLGAAALSGIVPVGLNPTRRGAALARDIAHADCQLVLTESAHAELLdGLDPGVRVINVDSPAwadEL 136

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1697 AGYPESDPQ-SAVGVDNLAYVIYTSGSTGKPKGTLLPH------GNVLrlfdATRhwFGFSADD----AWSLFHSYAF-- 1763
Cdd:PRK07867   137 AAHRDAEPPfRVADPDDLFMLIFTSGTSGDPKAVRCTHrkvasaGVML----AQR--FGLGPDDvcyvSMPLFHSNAVma 210

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1764 DFSVweifgaLLHGGRLVIVPYETSRSpeDFLRLLCRERVTVLNQTPSAFKQLMqvacAGQEVPPLA---LRhVVFGGEA 1840
Cdd:PRK07867   211 GWAV------ALAAGASIALRRKFSAS--GFLPDVRRYGATYANYVGKPLSYVL----ATPERPDDAdnpLR-IVYGNEG 277

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1841 LEVqALRPWFERFGdraPRLVNMYGITETTVHVTYRPlsladldGGAASPIGEPIPDLSWYLLDAGlNPVPRG------- 1913
Cdd:PRK07867   278 APG-DIARFARRFG---CVVVDGFGSTEGGVAITRTP-------DTPPGALGPLPPGVAIVDPDTG-TECPPAedadgrl 345

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1914 -----CIGELY-VGGAGLARGYLNRPElsctrfvADPFSTTGGRlYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELG 1987
Cdd:PRK07867   346 lnadeAIGELVnTAGPGGFEGYYNDPE-------ADAERMRGGV-YWSGDLAYRDADGYAYFAGRLGDWMRVDGENLGTA 417

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1988 EIEARLLAQPGVAEAVV--LPHEGPGATQLVGYVVTQAAPSDPAALRDTLRQalKASLPEHMVPAHLLFLERLPLTANGK 2065
Cdd:PRK07867   418 PIERILLRYPDATEVAVyaVPDPVVGDQVMAALVLAPGAKFDPDAFAEFLAA--QPDLGPKQWPSYVRVCAELPRTATFK 495


                   ....*...
gi 2183974163 2066 LDRRALPA 2073
Cdd:PRK07867   496 VLKRQLSA 503

PRK07529

AMP-binding domain protein; Validated

1566-2071

4.67e-23

AMP-binding domain protein; Validated

Pssm-ID: 236043 [Multi-domain] Cd Length: 632 Bit Score: 107.35 E-value: 4.67e-23

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1566 PAScLHRLIERQAAERPRATAVVYGERA--------LDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLA 1637
Cdd:PRK07529    24 PAS-TYELLSRAAARHPDAPALSFLLDAdpldrpetWTYAELLADVTRTANLLHSLGVGPGDVVAFLLPNLPETHFALWG 102

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1638 ILKAGGAyVPLDPRYPSDRLGYMIEDSGIRLLLT----------QRAARERLPLGEGLPCLLLD-AEH------------ 1694
Cdd:PRK07529   103 GEAAGIA-NPINPLLEPEQIAELLRAAGAKVLVTlgpfpgtdiwQKVAEVLAALPELRTVVEVDlARYlpgpkrlavpli 181

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1695 -------------EWAGYPES--DPQSAVGVDNLAYVIYTSGSTGKPKGTLLPHGNvlrlfDATRHW-----FGFSADD- 1753
Cdd:PRK07529   182 rrkaharildfdaELARQPGDrlFSGRPIGPDDVAAYFHTGGTTGMPKLAQHTHGN-----EVANAWlgallLGLGPGDt 256

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1754 ---AWSLFHSYAfdfSVWEIFGALLHGGRLVIVPYETSRSPE---DFLRLLCRERVTVLNQTPSAFKQLMQVACAGQEVP 1827
Cdd:PRK07529   257 vfcGLPLFHVNA---LLVTGLAPLARGAHVVLATPQGYRGPGviaNFWKIVERYRINFLSGVPTVYAALLQVPVDGHDIS 333

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1828 plALRHVVFGGEALEVQALRpwfeRFGDRAP-RLVNMYGITETTVHVTYRPLSLADLDGGaaspIGEPIPdlswY----- 1901
Cdd:PRK07529   334 --SLRYALCGAAPLPVEVFR----RFEAATGvRIVEGYGLTEATCVSSVNPPDGERRIGS----VGLRLP----Yqrvrv 399

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1902 --LLDAG--LNPVPRGCIGELYVGGAGLARGYLNrpelscTRFVADPFstTGGRLYRTGDLARYRCDGVVEYVGRidhqV 1977
Cdd:PRK07529   400 viLDDAGryLRDCAVDEVGVLCIAGPNVFSGYLE------AAHNKGLW--LEDGWLNTGDLGRIDADGYFWLTGR----A 467

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1978 K---IR-GFRIELGEIEARLLAQPGVAEAVVLPHEGPGATQL-VGYV-VTQAAPSDPAALRDTLRQAL--KASLPEHMVP 2049
Cdd:PRK07529   468 KdliIRgGHNIDPAAIEEALLRHPAVALAAAVGRPDAHAGELpVAYVqLKPGASATEAELLAFARDHIaeRAAVPKHVRI 547

                          570       580
                   ....*....|....*....|..
gi 2183974163 2050 ahllfLERLPLTANGKLDRRAL 2071
Cdd:PRK07529   548 -----LDALPKTAVGKIFKPAL 564

PRK09274

peptide synthase; Provisional

514-1007

6.76e-23

peptide synthase; Provisional

Pssm-ID: 236443 [Multi-domain] Cd Length: 552 Bit Score: 106.14 E-value: 6.76e-23

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  514 RLFEAQAGLTPDAPALLFGE----------ERLSYAELNALANRLAWRLREEGVGSDVlvgialeRGVPMV-------VA 576
Cdd:PRK09274    10 RHLPRAAQERPDQLAVAVPGgrgadgklayDELSFAELDARSDAIAHGLNAAGIGRGM-------RAVLMVtpsleffAL 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  577 LLAVLKAGGAYVPLDPQYPADRLQYMIDDSG------------LRLLL--SQQSVLARLPQSDGLqSLLLDDLERLVHGY 642
Cdd:PRK09274    83 TFALFKAGAVPVLVDPGMGIKNLKQCLAEAQpdafigipkahlARRLFgwGKPSVRRLVTVGGRL-LWGGTTLATLLRDG 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  643 PAENPDLPE-APDSLCYAIYTSGSTGQPKGVMVRHRALTNFVCSIARQPGMLARDRLLSvttfSFDIFGLelyVPLARGA 721
Cdd:PRK09274   162 AAAPFPMADlAPDDMAAILFTSGSTGTPKGVVYTHGMFEAQIEALREDYGIEPGEIDLP----TFPLFAL---FGPALGM 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  722 SMLL----ASREQAQDPEALLDLVERQGVTVLQATPATWRML---CDSERVDL--LRgcTLLCGGEALAEDLAARMRGL- 791
Cdd:PRK09274   235 TSVIpdmdPTRPATVDPAKLFAAIERYGVTNLFGSPALLERLgryGEANGIKLpsLR--RVISAGAPVPIAVIERFRAMl 312

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  792 --SASTWNLYGPTE----TTIwSARFRLGEEARPF-------LGGPLENTALYILD---------SEMNPCPPGVAGELL 849
Cdd:PRK09274   313 ppDAEILTPYGATEalpiSSI-ESREILFATRAATdngagicVGRPVDGVEVRIIAisdapipewDDALRLATGEIGEIV 391

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  850 IGGDGLARGYHRRPGLTAERFLPDPfaaDGSRLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSV 929
Cdd:PRK09274   392 VAGPMVTRSYYNRPEATRLAKIPDG---QGDVWHRMGDLGYLDAQGRLWFCGRKAHRVETAGGTLYTIPCERIFNTHPGV 468

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  930 -REAVV-VAQPGVAGPTLVaylVPTEAALVDAESARQQELRS-ALKNSLLAVLPDYmvpahmLLLENLPLTP--NGKINR 1004
Cdd:PRK09274   469 kRSALVgVGVPGAQRPVLC---VELEPGVACSKSALYQELRAlAAAHPHTAGIERF------LIHPSFPVDIrhNAKIFR 539


                   ...
gi 2183974163 1005 KAL 1007
Cdd:PRK09274   540 EKL 542

C_PKS-NRPS_PksJ-like

Condensation domain of hybrid polyketide synthetase/nonribosomal peptide synthetases (PKS ...

2742-2941

1.20e-22

Pssm-ID: 380472 [Multi-domain] Cd Length: 430 Bit Score: 103.94 E-value: 1.20e-22

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2742 FELAEAPLLRLVLVRTGERRHHLIYTNHHILMDGWSNSQLLGEVLQRY----RGETP--SRSDGRYRDYIAWLQRQDAGR 2815
Cdd:cd20484    103 FVLENGPLMRVHLFSRSEQEHFVLITIHHIIFDGSSSLTLIHSLLDAYqallQGKQPtlASSPASYYDFVAWEQDMLAGA 182

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2816 T----EAFWKQRLQrlGE-PTLLVPAF--AHGVRGAEGHADRYRqLDVTTSQRLAEFAREQKVTLNTLVQAAWLILLQRF 2888
Cdd:cd20484    183 EgeehRAYWKQQLS--GTlPILELPADrpRSSAPSFEGQTYTRR-LPSELSNQIKSFARSQSINLSTVFLGIFKLLLHRY 259

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2183974163 2889 TGQDTVAFGATVSGRPAElrGIEEQIGLFINTLPVVASPCPEQPIGDWLQAVQ 2941
Cdd:cd20484    260 TGQEDIIVGMPTMGRPEE--RFDSLIGYFINMLPIRSRILGEETFSDFIRKLQ 310

PRK13388

acyl-CoA synthetase; Provisional

1573-2073

1.42e-22

acyl-CoA synthetase; Provisional

Pssm-ID: 237374 [Multi-domain] Cd Length: 540 Bit Score: 105.11 E-value: 1.42e-22

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1573 LIERQAAERPratAVVYGERALDYGELNLRANRLAHRLIELGVGPDVL-VGLAAERSLEMIVGLLAILKAGGAYVPLDPR 1651
Cdd:PRK13388     9 LRDRAGDDTI---AVRYGDRTWTWREVLAEAAARAAALIALADPDRPLhVGVLLGNTPEMLFWLAAAALGGYVLVGLNTT 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1652 YPSDRLGYMIEDSGIRLLLTQRAARERLPlGEGLPC--LLLDAEHEWA----GYPESDPQSAVGVDNLAYVIYTSGSTGK 1725
Cdd:PRK13388    86 RRGAALAADIRRADCQLLVTDAEHRPLLD-GLDLPGvrVLDVDTPAYAelvaAAGALTPHREVDAMDPFMLIFTSGTTGA 164

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1726 PKGTLLPHGNVLRLFDATRHWFGFSADD----AWSLFHSYAFdFSVWEIfgALLHGGRLVIVPyetSRSPEDFLRLLCRE 1801
Cdd:PRK13388   165 PKAVRCSHGRLAFAGRALTERFGLTRDDvcyvSMPLFHSNAV-MAGWAP--AVASGAAVALPA---KFSASGFLDDVRRY 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1802 RVTVLNQTPSAFKQLMqvacAGQEVPPLA---LRhVVFGGEALEvQALRPWFERFGdraPRLVNMYGITETTVHVTYRPl 1878
Cdd:PRK13388   239 GATYFNYVGKPLAYIL----ATPERPDDAdnpLR-VAFGNEASP-RDIAEFSRRFG---CQVEDGYGSSEGAVIVVREP- 308

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1879 sladldGGAASPIGEPIPDLSWYLLDAG--------------LNpvPRGCIGELY-VGGAGLARGYLNRPELSCTRFvad 1943
Cdd:PRK13388   309 ------GTPPGSIGRGAPGVAIYNPETLtecavarfdahgalLN--ADEAIGELVnTAGAGFFEGYYNNPEATAERM--- 377

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1944 pfstTGGRlYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVV--LPHEGPGATQLVGYVVT 2021
Cdd:PRK13388   378 ----RHGM-YWSGDLAYRDADGWIYFAGRTADWMRVDGENLSAAPIERILLRHPAINRVAVyaVPDERVGDQVMAALVLR 452

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2183974163 2022 QAAPSDPAALRDTLrqALKASLPEHMVPAHLLFLERLPLTANGKLDRRALPA 2073
Cdd:PRK13388   453 DGATFDPDAFAAFL--AAQPDLGTKAWPRYVRIAADLPSTATNKVLKRELIA 502

FUM14_C_NRPS-like

Condensation domains of nonribosomal peptide synthetases (NRPSs) similar to the ester-bond ...

1130-1533

1.96e-22

Pssm-ID: 380467 [Multi-domain] Cd Length: 395 Bit Score: 102.76 E-value: 1.96e-22

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1130 HSAAYNIPVALRLKGPLRRDALQGALDLLVQRHETLRTTFVEHD-GAPRQVIHPTLPIAIEERRppvageDLKGLVETEA 1208
Cdd:cd19545     18 QPGAYVGQRVFELPPDIDLARLQAAWEQVVQANPILRTRIVQSDsGGLLQVVVKESPISWTEST------SLDEYLEEDR 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1209 HRPFDLQrGPLLRVLLLPLATDECVLVLTLHHIIADGWSMQVLVDELIRVYAALRHDQPPalaelpiQYADFAAW-QRQW 1287
Cdd:cd19545     92 AAPMGLG-GPLVRLALVEDPDTERYFVWTIHHALYDGWSLPLILRQVLAAYQGEPVPQPP-------PFSRFVKYlRQLD 163

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1288 MDGGErerqlDYWVSRLGGEQPLL--ELPSDRPRPQQQSHRGRRIGIPLPAELaealrrlaqaeQGTLFMLLLASFQALL 1365
Cdd:cd19545    164 DEAAA-----EFWRSYLAGLDPAVfpPLPSSRYQPRPDATLEHSISLPSSASS-----------GVTLATVLRAAWALVL 227

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1366 HRYSGQNDIRVGVPIANRN--REETEGLIGFFVNTQVLRAELDGQLPFRELLRQVRQAVVEAqghqdLPFEQLvdALQPE 1443
Cdd:cd19545    228 SRYTGSDDVVFGVTLSGRNapVPGIEQIVGPTIATVPLRVRIDPEQSVEDFLQTVQKDLLDM-----IPFEHT--GLQNI 300

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1444 RSLS----HAPLFQVMYNHQRDDHR---GSRFASLGELEVEDLAWDvqtaQFDLTLDTYESSNGLLAELTYATDLFDASS 1516
Cdd:cd19545    301 RRLGpdarAACNFQTLLVVQPALPSstsESLELGIEEESEDLEDFS----SYGLTLECQLSGSGLRVRARYDSSVISEEQ 376

                          410
                   ....*....|....*..
gi 2183974163 1517 AERIAGHWLNLLRSIVA 1533
Cdd:cd19545    377 VERLLDQFEHVLQQLAS 393

MACS_euk

cd05928

Eukaryotic Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step ...

519-1007

3.00e-22

Eukaryotic Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. The acyl-CoA is a key intermediate in many important biosynthetic and catabolic processes. MACS enzymes are localized to mitochondria. Two murine MACS family proteins are found in liver and kidney. In rodents, a MACS member is detected particularly in the olfactory epithelium and is called O-MACS. O-MACS demonstrates substrate preference for the fatty acid lengths of C6-C12.

Pssm-ID: 341251 [Multi-domain] Cd Length: 530 Bit Score: 104.08 E-value: 3.00e-22

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  519 QAGLTPDAPALLF----GEE-RLSYAELNALANRLAwrlreegvgsDVLVGI-ALERGVPMVVAL----------LAVLK 582
Cdd:cd05928     20 KAGKRPPNPALWWvngkGDEvKWSFRELGSLSRKAA----------NVLSGAcGLQRGDRVAVILprvpewwlvnVACIR 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  583 AGGAYVPLDPQYPADRLQYMIDDSGLRLLLSQQSVLARL----PQSDGLQS-LLLDDLERlvHGYPAENPDLPEAPDS-L 656
Cdd:cd05928     90 TGLVFIPGTIQLTAKDILYRLQASKAKCIVTSDELAPEVdsvaSECPSLKTkLLVSEKSR--DGWLNFKELLNEASTEhH 167

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  657 C--------YAIY-TSGSTGQPKgvMVRHRAltnfvCSIARQPGMLARdRLLSVTtfSFDIF------------GLELYV 715
Cdd:cd05928    168 CvetgsqepMAIYfTSGTTGSPK--MAEHSH-----SSLGLGLKVNGR-YWLDLT--ASDIMwntsdtgwiksaWSSLFE 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  716 PLARGASMLLASREQAqDPEALLDLVERQGVTVLQATPATWRMLCD----SERVDLLRGCtlLCGGEALAEDLAARMRGL 791
Cdd:cd05928    238 PWIQGACVFVHHLPRF-DPLVILKTLSSYPITTFCGAPTVYRMLVQqdlsSYKFPSLQHC--VTGGEPLNPEVLEKWKAQ 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  792 SA-STWNLYGPTETTIWSARFRlGEEARP-FLGGPLENTALYILDSEMNPCPPGVAGELLIGGD-----GLARGYHRRPG 864
Cdd:cd05928    315 TGlDIYEGYGQTETGLICANFK-GMKIKPgSMGKASPPYDVQIIDDNGNVLPPGTEGDIGIRVKpirpfGLFSGYVDNPE 393

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  865 LTAERFLPDpfaadgsrLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQPG-VAGP 943
Cdd:cd05928    394 KTAATIRGD--------FYLTGDRGIMDEDGYFWFMGRADDVINSSGYRIGPFEVESALIEHPAVVESAVVSSPDpIRGE 465

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2183974163  944 TLVAYLVPTEAALVDAESARQQELRSALKNsllaVLPDYMVPAHMLLLENLPLTPNGKINRKAL 1007
Cdd:cd05928    466 VVKAFVVLAPQFLSHDPEQLTKELQQHVKS----VTAPYKYPRKVEFVQELPKTVTGKIQRNEL 525

BACL_like

cd05929

Bacterial Bile acid CoA ligases and similar proteins; Bile acid-Coenzyme A ligase catalyzes ...

1578-2071

3.13e-22

Bacterial Bile acid CoA ligases and similar proteins; Bile acid-Coenzyme A ligase catalyzes the formation of bile acid-CoA conjugates in a two-step reaction: the formation of a bile acid-AMP molecule as an intermediate, followed by the formation of a bile acid-CoA. This ligase requires a bile acid with a free carboxyl group, ATP, Mg2+, and CoA for synthesis of the final bile acid-CoA conjugate. The bile acid-CoA ligation is believed to be the initial step in the bile acid 7alpha-dehydroxylation pathway in the intestinal bacterium Eubacterium sp.

Pssm-ID: 341252 [Multi-domain] Cd Length: 473 Bit Score: 103.23 E-value: 3.13e-22

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1578 AAERPRATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDrl 1657
Cdd:cd05929      2 EARDLDRAQVFHQRRLLLLDVYSIALNRNARAAAAEGVWIADGVYIYLINSILTVFAAAAAWKCGACPAYKSSRAPRA-- 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1658 gymiEDSGIrLLLTQRAARERLPLGEGLPCLLLDAEHEWAGYPESDPQSAVgvdNLAYVIYTSGSTGKPKGTLLPHGNVL 1737
Cdd:cd05929     80 ----EACAI-IEIKAAALVCGLFTGGGALDGLEDYEAAEGGSPETPIEDEA---AGWKMLYSGGTTGRPKGIKRGLPGGP 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1738 RLFDATRHW---FGFSADDAW----SLFHSYAFDFSvweiFGALLHGGRLVIVPyetSRSPEDFLRLLCRERVTVLNQTP 1810
Cdd:cd05929    152 PDNDTLMAAalgFGPGADSVYlspaPLYHAAPFRWS----MTALFMGGTLVLME---KFDPEEFLRLIERYRVTFAQFVP 224

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1811 SAFKQLMQVACAGQEVPPLA-LRHVVFGGEALEVQALRPWFERFGdraPRLVNMYGITETTvhvtyrPLSLADLDGGAAS 1889
Cdd:cd05929    225 TMFVRLLKLPEAVRNAYDLSsLKRVIHAAAPCPPWVKEQWIDWGG---PIIWEYYGGTEGQ------GLTIINGEEWLTH 295

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1890 P--IGEPI-PDLSwyLLDAGLNPVPRGCIGELYVGGAGlARGYLNRPELSCTRFVADPFSTTGgrlyrtgDLARYRCDGV 1966
Cdd:cd05929    296 PgsVGRAVlGKVH--ILDEDGNEVPPGEIGEVYFANGP-GFEYTNDPEKTAAARNEGGWSTLG-------DVGYLDEDGY 365

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1967 VEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVV--LPHEGPGatQLVGYVVtQAAPSDPA--ALRDTLRQALKAS 2042
Cdd:cd05929    366 LYLTDRRSDMIISGGVNIYPQEIENALIAHPKVLDAAVvgVPDEELG--QRVHAVV-QPAPGADAgtALAEELIAFLRDR 442

                          490       500
                   ....*....|....*....|....*....
gi 2183974163 2043 LPEHMVPAHLLFLERLPLTANGKLDRRAL 2071
Cdd:cd05929    443 LSRYKCPRSIEFVAELPRDDTGKLYRRLL 471

PRK13382

bile acid CoA ligase;

1578-2074

3.45e-22

bile acid CoA ligase;

Pssm-ID: 172019 [Multi-domain] Cd Length: 537 Bit Score: 103.68 E-value: 3.45e-22

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1578 AAER-PRATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDR 1656
Cdd:PRK13382    52 AAQRcPDRPGLIDELGTLTWRELDERSDALAAALQALPIGEPRVVGIMCRNHRGFVEALLAANRIGADILLLNTSFAGPA 131

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1657 LGYMIEDSGIRLL--------LTQRAARER--------LPLGEG-LPCLLLDAEHEWAGYPESDPQSAVgvdnlayVIYT 1719
Cdd:PRK13382   132 LAEVVTREGVDTViydeefsaTVDRALADCpqatrivaWTDEDHdLTVEVLIAAHAGQRPEPTGRKGRV-------ILLT 204

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1720 SGSTGKPKGTLLP----HGNVLRLFDAT----RHWFGFSAddawSLFHSYAFDFSVweiFGALLhggRLVIVpyeTSR-- 1789
Cdd:PRK13382   205 SGTTGTPKGARRSgpggIGTLKAILDRTpwraEEPTVIVA----PMFHAWGFSQLV---LAASL---ACTIV---TRRrf 271

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1790 SPEDFLRLLCRERVTVLNQTPSAFKQLMqvacagqEVPP--------LALRHVVFGGEALEVQALRPWFERFGDRaprLV 1861
Cdd:PRK13382   272 DPEATLDLIDRHRATGLAVVPVMFDRIM-------DLPAevrnrysgRSLRFAAASGSRMRPDVVIAFMDQFGDV---IY 341

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1862 NMYGITETTVHVTYRPlslADLDGgAASPIGEPIPDLSWYLLDAGLNPVPRGCIGELYVGGAGLARGYLNrpelSCTRFV 1941
Cdd:PRK13382   342 NNYNATEAGMIATATP---ADLRA-APDTAGRPAEGTEIRILDQDFREVPTGEVGTIFVRNDTQFDGYTS----GSTKDF 413

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1942 ADPFSTTGgrlyrtgDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVVLPHEGPGATQ-LVGYVV 2020
Cdd:PRK13382   414 HDGFMASG-------DVGYLDENGRLFVVGRDDEMIVSGGENVYPIEVEKTLATHPDVAEAAVIGVDDEQYGQrLAAFVV 486

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2183974163 2021 TQAapsDPAALRDTLRQALKASLPEHMVPAHLLFLERLPLTANGKLDRRALPAP 2074
Cdd:PRK13382   487 LKP---GASATPETLKQHVRDNLANYKVPRDIVVLDELPRGATGKILRRELQAR 537

PRK08276

long-chain-fatty-acid--CoA ligase; Validated

531-1007

4.88e-22

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 236215 [Multi-domain] Cd Length: 502 Bit Score: 103.06 E-value: 4.88e-22

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  531 FGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQYMIDDSGLRL 610
Cdd:PRK08276     7 PSGEVVTYGELEARSNRLAHGLRALGLREGDVVAILLENNPEFFEVYWAARRSGLYYTPINWHLTAAEIAYIVDDSGAKV 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  611 LLSQ-------QSVLARLPQsdGLQSLLLDD--------LERLVHGYPAENPDLPEAPDSLcyaIYTSGSTGQPKGVMvr 675
Cdd:PRK08276    87 LIVSaaladtaAELAAELPA--GVPLLLVVAgpvpgfrsYEEALAAQPDTPIADETAGADM---LYSSGTTGRPKGIK-- 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  676 hRALTNfvCSIARQPGMLARdrllsVTTFSFDIFGLELYV---PLARGASMLLASREQAQ----------DPEALLDLVE 742
Cdd:PRK08276   160 -RPLPG--LDPDEAPGMMLA-----LLGFGMYGGPDSVYLspaPLYHTAPLRFGMSALALggtvvvmekfDAEEALALIE 231

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  743 RQGVTVLQATPATW-RMLCDSERV----DL--LRGctLLCGGEALAEDLAARMrglsaSTW------NLYGPTE----TT 805
Cdd:PRK08276   232 RYRVTHSQLVPTMFvRMLKLPEEVraryDVssLRV--AIHAAAPCPVEVKRAM-----IDWwgpiihEYYASSEgggvTV 304

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  806 IWSARF--RLGEEARPFLGGplentaLYILDSEMNPCPPGVAGELLIGGDGLARGYHRRPGLTAERFLPDPFAAdgsrly 883
Cdd:PRK08276   305 ITSEDWlaHPGSVGKAVLGE------VRILDEDGNELPPGEIGTVYFEMDGYPFEYHNDPEKTAAARNPHGWVT------ 372

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  884 rTGDLARYRADGvieYL---GRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVaqpGVA----GPTLVAYLVPteAAL 956
Cdd:PRK08276   373 -VGDVGYLDEDG---YLyltDRKSDMIISGGVNIYPQEIENLLVTHPKVADVAVF---GVPdeemGERVKAVVQP--ADG 443

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2183974163  957 VDAESARQQELRSALKNSLLAvlpdYMVPAHMLLLENLPLTPNGKINRKAL 1007
Cdd:PRK08276   444 ADAGDALAAELIAWLRGRLAH----YKCPRSIDFEDELPRTPTGKLYKRRL 490

A_NRPS_GliP_like

cd17653

nonribosomal peptide synthase GliP-like; This family includes the adenylation (A) domain of ...

3089-3182

5.50e-22

Pssm-ID: 341308 [Multi-domain] Cd Length: 433 Bit Score: 102.00 E-value: 5.50e-22

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3089 RLFEEQVERTPTAPALAFGEERLDYAELNRRANRLAHALIERGIGADRLVGVAMERSIEMVVALMAILKAGGAYVPVDPE 3168
Cdd:cd17653      1 DAFERIAAAHPDAVAVESLGGSLTYGELDAASNALANRLLQLGVVPGDVVPLLSDRSLEMLVAILAILKAGAAYVPLDAK 80

                           90
                   ....*....|....
gi 2183974163 3169 YPEERQAYMLEDSG 3182
Cdd:cd17653     81 LPSARIQAILRTSG 94

PRK12406

long-chain-fatty-acid--CoA ligase; Provisional

528-1007

5.70e-22

long-chain-fatty-acid--CoA ligase; Provisional

Pssm-ID: 183506 [Multi-domain] Cd Length: 509 Bit Score: 102.85 E-value: 5.70e-22

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  528 ALLFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQYMIDDSG 607
Cdd:PRK12406     4 TIISGDRRRSFDELAQRAARAAGGLAALGVRPGDCVALLMRNDFAFFEAAYAAMRLGAYAVPVNWHFKPEEIAYILEDSG 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  608 LRLLLSQQSVLA----RLPQsdGLQSLL------------LDDLER------------LVHGYPAENPDLPeAPDSLcya 659
Cdd:PRK12406    84 ARVLIAHADLLHglasALPA--GVTVLSvptppeiaaayrISPALLtppagaidwegwLAQQEPYDGPPVP-QPQSM--- 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  660 IYTSGSTGQPKGVmvRHRALT-----NFVCSIARQPGMLARDRLL------SVTTFSFDIFGLELyvplarGASMLLASR 728
Cdd:PRK12406   158 IYTSGTTGHPKGV--RRAAPTpeqaaAAEQMRALIYGLKPGIRALltgplyHSAPNAYGLRAGRL------GGVLVLQPR 229

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  729 eqaQDPEALLDLVERQGVTVLQATPATWRMLCD-----SERVDL--LRGCTLlcGGEALAEDLAARMrglsASTW----- 796
Cdd:PRK12406   230 ---FDPEELLQLIERHRITHMHMVPTMFIRLLKlpeevRAKYDVssLRHVIH--AAAPCPADVKRAM----IEWWgpviy 300

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  797 NLYGPTETTIwsARFRLGEEA--RP-FLGGPLENTALYILDSEMNPCPPGVAGELLIGGDGLAR-GYHRRPGLTAErflp 872
Cdd:PRK12406   301 EYYGSTESGA--VTFATSEDAlsHPgTVGKAAPGAELRFVDEDGRPLPQGEIGEIYSRIAGNPDfTYHNKPEKRAE---- 374

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  873 dpfaADGSRLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQPGVA-GPTLVAYLVP 951
Cdd:PRK12406   375 ----IDRGGFITSGDVGYLDADGYLFLCDRKRDMVISGGVNIYPAEIEAVLHAVPGVHDCAVFGIPDAEfGEALMAVVEP 450

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2183974163  952 TEAALVDAEsarqqELRSALKNSllavLPDYMVPAHMLLLENLPLTPNGKINRKAL 1007
Cdd:PRK12406   451 QPGATLDEA-----DIRAQLKAR----LAGYKVPKHIEIMAELPREDSGKIFKRRL 497

AcpA

COG3433

Acyl carrier protein/domain [Lipid transport and metabolism, Secondary metabolites ...

1874-2152

6.04e-22

Acyl carrier protein/domain [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism];

Pssm-ID: 442659 [Multi-domain] Cd Length: 295 Bit Score: 99.05 E-value: 6.04e-22

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1874 TYRPLSLADLDGGAASPIGEPIPDLSWYLLDAGLNPVPRGCIGELYVGGAGLARGYLNRPELSCTRFVADPFSTTGGRLY 1953
Cdd:COG3433      3 IATPPPAPPTPDEPPPVIPPAIVQARALLLIVDLQGYFGGFGGEGGLLGAGLLLRIRLLAAAARAPFIPVPYPAQPGRQA 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1954 RTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVVLPHEGPGATQLVGYVVTQAAPSDPAALRD 2033
Cdd:COG3433     83 DDLRLLLRRGLGPGGGLERLVQQVVIRAERGEEEELLLVLRAAAVVRVAVLAALRGAGVGLLLIVGAVAALDGLAAAAAL 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2034 tlrqALKASLPEHMVPAHLLFLERLPLTANGKLDRRALPAPDASRLQRDYTAPRS-----ELEQRLAAIWADVLKLG--R 2106
Cdd:COG3433    163 ----AALDKVPPDVVAASAVVALDALLLLALKVVARAAPALAAAEALLAAASPAPaletaLTEEELRADVAELLGVDpeE 238

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 2183974163 2107 VGLDDNFFELGGDSIISIQVVSRARQAGIRLAPRDLFLHQTIRGLA 2152
Cdd:COG3433    239 IDPDDNLFDLGLDSIRLMQLVERWRKAGLDVSFADLAEHPTLAAWW 284

MACS_euk

cd05928

Eukaryotic Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step ...

1686-2071

6.44e-22

Pssm-ID: 341251 [Multi-domain] Cd Length: 530 Bit Score: 102.93 E-value: 6.44e-22

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1686 PCL---LLDAEHEWAGYPE--------SDPQSAVGVDNL-AYVIY-TSGSTGKPKGTLLPHGNV-LRLFDATRHWFGFSA 1751
Cdd:cd05928    136 PSLktkLLVSEKSRDGWLNfkellneaSTEHHCVETGSQePMAIYfTSGTTGSPKMAEHSHSSLgLGLKVNGRYWLDLTA 215

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1752 DD-AWSLFHSYAFDFSVWEIFGALLHGGrLVIVPYETSRSPEDFLRLLCRERVTVLNQTPSAFKQLMQVACAGQEVPplA 1830
Cdd:cd05928    216 SDiMWNTSDTGWIKSAWSSLFEPWIQGA-CVFVHHLPRFDPLVILKTLSSYPITTFCGAPTVYRMLVQQDLSSYKFP--S 292

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1831 LRHVVFGGEALEVQALRPWFERFGdraPRLVNMYGITETTvhvtyrpLSLADLDGGAASP--IGEPIPDLSWYLLDAGLN 1908
Cdd:cd05928    293 LQHCVTGGEPLNPEVLEKWKAQTG---LDIYEGYGQTETG-------LICANFKGMKIKPgsMGKASPPYDVQIIDDNGN 362

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1909 PVPRGCIGELYVggaglaRGYLNRPELSCTRFVADPFSTTG---GRLYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIE 1985
Cdd:cd05928    363 VLPPGTEGDIGI------RVKPIRPFGLFSGYVDNPEKTAAtirGDFYLTGDRGIMDEDGYFWFMGRADDVINSSGYRIG 436

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1986 LGEIEARLLAQPGVAEAVVLPHEGPGATQLVGYVVTQAAP---SDPAALRDTLRQALKASLPEHMVPAHLLFLERLPLTA 2062
Cdd:cd05928    437 PFEVESALIEHPAVVESAVVSSPDPIRGEVVKAFVVLAPQflsHDPEQLTKELQQHVKSVTAPYKYPRKVEFVQELPKTV 516


                   ....*....
gi 2183974163 2063 NGKLDRRAL 2071
Cdd:cd05928    517 TGKIQRNEL 525

CT_NRPS-like

Terminal Condensation (CT)-like domains of nonribosomal peptide synthetases (NRPSs); Unlike ...

2174-2600

6.85e-22

Pssm-ID: 380464 [Multi-domain] Cd Length: 401 Bit Score: 101.23 E-value: 6.85e-22

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2174 PLLPIQQMFFE--LDIPRRqHWNQSVLlEPGQALDGTLLETALQALLAHHDALRLGFrledgtwraehrAVEAGEVLLWQ 2251
Cdd:cd19542      3 PCTPMQEGMLLsqLRSPGL-YFNHFVF-DLDSSVDVERLRNAWRQLVQRHDILRTVF------------VESSAEGTFLQ 68

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2252 ----------QSVADgqALEALAEQVQRSLD---LGSGPLLRALLATLGDGSQRLLLVIHHLVVDGVSWRILLEDLQTAY 2318
Cdd:cd19542     69 vvlksldppiEEVET--DEDSLDALTRDLLDdptLFGQPPHRLTLLETSSGEVYLVLRISHALYDGVSLPIILRDLAAAY 146

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2319 RQlqagqavALPAKTSAFKAWAERLQAHARDGGLEgergYWLAQLEGVST-ELPC--DDREGAQSVRHVRSARTElteea 2395
Cdd:cd19542    147 NG-------QLLPPAPPFSDYISYLQSQSQEESLQ----YWRKYLQGASPcAFPSlsPKRPAERSLSSTRRSLAK----- 210

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2396 trrlLQEAPAAYRTQVNDLLLTALARVIGRWTGQAD----TLIqlegHGREELFEDIDltRTVGWFTSLFPLRLS----- 2466
Cdd:cd19542    211 ----LEAFCASLGVTLASLFQAAWALVLARYTGSRDvvfgYVV----SGRDLPVPGID--DIVGPCINTLPVRVKldpdw 280

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2467 PVAELgasIKRIKEQ-LRAIPHKGLGFGAL-RYLGSAEDRAALAALpspritFNYLGQFD-GSFSADSSALFRPSADAAG 2543
Cdd:cd19542    281 TVLDL---LRQLQQQyLRSLPHQHLSLREIqRALGLWPSGTLFNTL------VSYQNFEAsPESELSGSSVFELSAAEDP 351

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2183974163 2544 SERDsdapldnwLSLNGQVYAGRLGIDWSFSAARFSEASILRLADAYRDELLALIEH 2600
Cdd:cd19542    352 TEYP--------VAVEVEPSGDSLKVSLAYSTSVLSEEQAEELLEQFDDILEALLAN 400

ACS

cd05966

Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); ...

524-1017

1.55e-21

Pssm-ID: 341270 [Multi-domain] Cd Length: 608 Bit Score: 102.25 E-value: 1.55e-21

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  524 PDAPALLF-GEE-----RLSYAELNALANRLAWRLREEGVGSDVLVGIALergvPM----VVALLA---------VLKAG 584
Cdd:cd05966     67 GDKVAIIWeGDEpdqsrTITYRELLREVCRFANVLKSLGVKKGDRVAIYM----PMipelVIAMLAcarigavhsVVFAG 142

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  585 gayvpldpqYPADRLQYMIDDSGLRLLLSQQSVLAR-------------LPQSDGLQSLL--------------LD-DLE 636
Cdd:cd05966    143 ---------FSAESLADRINDAQCKLVITADGGYRGgkviplkeivdeaLEKCPSVEKVLvvkrtggevpmtegRDlWWH 213

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  637 RLVHGYPAENPdlPEAPDSL--CYAIYTSGSTGQPKGVMvrHRaltnfvcsiarQPGMLardrLLSVTTFSF-------D 707
Cdd:cd05966    214 DLMAKQSPECE--PEWMDSEdpLFILYTSGSTGKPKGVV--HT-----------TGGYL----LYAATTFKYvfdyhpdD 274

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  708 IFGLE------------LYVPLARGASMLLasREQAQ---DPEALLDLVERQGVTVLQATPATWRMLC---DS--ERVDL 767
Cdd:cd05966    275 IYWCTadigwitghsyiVYGPLANGATTVM--FEGTPtypDPGRYWDIVEKHKVTIFYTAPTAIRALMkfgDEwvKKHDL 352

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  768 --LRgctlLCG--GEALAE-------DLAARMRGLSASTW-----------NLYGPTETTIWSArfrlgeeARPFLGGPL 825
Cdd:cd05966    353 ssLR----VLGsvGEPINPeawmwyyEVIGKERCPIVDTWwqtetggimitPLPGATPLKPGSA-------TRPFFGIEP 421

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  826 EntalyILDSEMNPCPPGVAGELLIGGD--GLARGYHRRPgltaERFLPDPFAADgSRLYRTGDLARYRADGVIEYLGRI 903
Cdd:cd05966    422 A-----ILDEEGNEVEGEVEGYLVIKRPwpGMARTIYGDH----ERYEDTYFSKF-PGYYFTGDGARRDEDGYYWITGRV 491

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  904 DHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQP-GVAGPTLVAYLVPTEAAlvdaesARQQELRSALKNSLLAVLPDY 982
Cdd:cd05966    492 DDVINVSGHRLGTAEVESALVAHPAVAEAAVVGRPhDIKGEAIYAFVTLKDGE------EPSDELRKELRKHVRKEIGPI 565

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|...
gi 2183974163  983 MVPAHMLLLENLPLTPNGKINRKAL--------PLPDASAVRD 1017
Cdd:cd05966    566 ATPDKIQFVPGLPKTRSGKIMRRILrkiaageeELGDTSTLAD 608

A_NRPS_TlmIV_like

cd12114

The adenylation domain of nonribosomal peptide synthetases (NRPS), including ...

3099-3183

1.58e-21

Pssm-ID: 341279 [Multi-domain] Cd Length: 477 Bit Score: 101.19 E-value: 1.58e-21

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3099 PTAPALAFGEERLDYAELNRRANRLAHALIERGIGADRLVGVAMERSIEMVVALMAILKAGGAYVPVDPEYPEERQAYML 3178
Cdd:cd12114      1 PDATAVICGDGTLTYGELAERARRVAGALKAAGVRPGDLVAVTLPKGPEQVVAVLGILAAGAAYVPVDIDQPAARREAIL 80


                   ....*
gi 2183974163 3179 EDSGV 3183
Cdd:cd12114     81 ADAGA 85

PRK12583

acyl-CoA synthetase; Provisional

509-1004

1.71e-21

acyl-CoA synthetase; Provisional

Pssm-ID: 237145 [Multi-domain] Cd Length: 558 Bit Score: 101.77 E-value: 1.71e-21

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  509 GQGVHRLFEAQAGLTPDAPALLFGEE--RLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGA 586
Cdd:PRK12583    17 TQTIGDAFDATVARFPDREALVVRHQalRYTWRQLADAVDRLARGLLALGVQPGDRVGIWAPNCAEWLLTQFATARIGAI 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  587 YVPLDPQYPADRLQYMIDDSGLRLLLSQQS---------VLARLP-----QSDGLQSLLLDDLERLVHGYPAENP----- 647
Cdd:PRK12583    97 LVNINPAYRASELEYALGQSGVRWVICADAfktsdyhamLQELLPglaegQPGALACERLPELRGVVSLAPAPPPgflaw 176

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  648 -------------DLPEAPDSLCY--AI---YTSGSTGQPKGVMVRHRALTNFVCSIARQPGMLARDRLLSVTTFsFDIF 709
Cdd:PRK12583   177 helqargetvsreALAERQASLDRddPIniqYTSGTTGFPKGATLSHHNILNNGYFVAESLGLTEHDRLCVPVPL-YHCF 255

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  710 GLEL--YVPLARGASMLLASreQAQDPEALLDLVERQGVTVLQATPATWRMLCDSERVDLLRGCTLLCGGEALAEDLAAR 787
Cdd:PRK12583   256 GMVLanLGCMTVGACLVYPN--EAFDPLATLQAVEEERCTALYGVPTMFIAELDHPQRGNFDLSSLRTGIMAGAPCPIEV 333

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  788 MRGL-----SASTWNLYGPTET---TIWSARFRLGEEARPFLGGPLENTALYILDSEMNPCPPGVAGELLIGGDGLARGY 859
Cdd:PRK12583   334 MRRVmdemhMAEVQIAYGMTETspvSLQTTAADDLERRVETVGRTQPHLEVKVVDPDGATVPRGEIGELCTRGYSVMKGY 413

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  860 HRRPGLTAErflpdpfAADGSRLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQP- 938
Cdd:PRK12583   414 WNNPEATAE-------SIDEDGWMHTGDLATMDEQGYVRIVGRSKDMIIRGGENIYPREIEEFLFTHPAVADVQVFGVPd 486

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2183974163  939 GVAGPTLVAYLVpteaaLVDAESARQQELRSALKnsllAVLPDYMVPAHMLLLENLPLTPNGKINR 1004
Cdd:PRK12583   487 EKYGEEIVAWVR-----LHPGHAASEEELREFCK----ARIAHFKVPRYFRFVDEFPMTVTGKVQK 543

AAS_C

cd05909

C-terminal domain of the acyl-acyl carrier protein synthetase (also called ...

536-1007

1.96e-21

Pssm-ID: 341235 [Multi-domain] Cd Length: 490 Bit Score: 100.87 E-value: 1.96e-21

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  536 LSYAEL--NALAnrLAWRLREEGVGSDvLVGIALERGVPMVVALLAVLKAGgaYVPLDPQYPA--DRLQYMIDDSGLRLL 611
Cdd:cd05909      8 LTYRKLltGAIA--LARKLAKMTKEGE-NVGVMLPPSAGGALANFALALSG--KVPVMLNYTAglRELRACIKLAGIKTV 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  612 LSQQSVLARLPQSDGL------QSLLLDDLER----------LVHGY-PAENPDL-----PEAPDSLCYAIYTSGSTGQP 669
Cdd:cd05909     83 LTSKQFIEKLKLHHLFdveydaRIVYLEDLRAkiskadkckaFLAGKfPPKWLLRifgvaPVQPDDPAVILFTSGSEGLP 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  670 KGVMVRHRALTNFVCSIARQPGMLARDRLLSVTTFsFDIFGLE--LYVPLARGASMLLASreQAQDPEALLDLVERQGVT 747
Cdd:cd05909    163 KGVVLSHKNLLANVEQITAIFDPNPEDVVFGALPF-FHSFGLTgcLWLPLLSGIKVVFHP--NPLDYKKIPELIYDKKAT 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  748 VLQATPATWRMLCDSERVDLLRGCTL-LCGGEALAEDLA---------ARMRGlsastwnlYGPTET------TIWSARF 811
Cdd:cd05909    240 ILLGTPTFLRGYARAAHPEDFSSLRLvVAGAEKLKDTLRqefqekfgiRILEG--------YGTTECspvisvNTPQSPN 311

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  812 RLGEearpfLGGPLENTALYILDSE-MNPCPPGVAGELLIGGDGLARGYHRRPGLTAERFlpdpfaADGsrLYRTGDLAR 890
Cdd:cd05909    312 KEGT-----VGRPLPGMEVKIVSVEtHEEVPIGEGGLLLVRGPNVMLGYLNEPELTSFAF------GDG--WYDTGDIGK 378

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  891 YRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLE--QDSVREAVVVAQPGVAGPTLVAYLVPTEAAlvdaesarQQELR 968
Cdd:cd05909    379 IDGEGFLTITGRLSRFAKIAGEMVSLEAIEDILSEilPEDNEVAVVSVPDGRKGEKIVLLTTTTDTD--------PSSLN 450

                          490       500       510
                   ....*....|....*....|....*....|....*....
gi 2183974163  969 SALKNSLLAVLpdyMVPAHMLLLENLPLTPNGKINRKAL 1007
Cdd:cd05909    451 DILKNAGISNL---AKPSYIHQVEEIPLLGTGKPDYVTL 486

PRK12492

long-chain-fatty-acid--CoA ligase; Provisional

508-1007

3.18e-21

long-chain-fatty-acid--CoA ligase; Provisional

Pssm-ID: 171539 [Multi-domain] Cd Length: 562 Bit Score: 101.05 E-value: 3.18e-21

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  508 AGQGVHRLFEAQAGLTPDAPALLFGEERLSYAELNALANRLAWRLREEgvgSDVLVGIALERGVPMV----VALLAVLKA 583
Cdd:PRK12492    22 AYKSVVEVFERSCKKFADRPAFSNLGVTLSYAELERHSAAFAAYLQQH---TDLVPGDRIAVQMPNVlqypIAVFGALRA 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  584 GGAYVPLDPQYPADRLQYMIDDSGLRLLL-------SQQSVLAR--------------LPQSDG-LQSLLLDDLERLVHG 641
Cdd:PRK12492    99 GLIVVNTNPLYTAREMRHQFKDSGARALVylnmfgkLVQEVLPDtgieylieakmgdlLPAAKGwLVNTVVDKVKKMVPA 178

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  642 YpaenpDLPEAP---------------------DSLCYAIYTSGSTGQPKGVMVRHralTNFVCSIARQPGMLARDRLLS 700
Cdd:PRK12492   179 Y-----HLPQAVpfkqalrqgrglslkpvpvglDDIAVLQYTGGTTGLAKGAMLTH---GNLVANMLQVRACLSQLGPDG 250

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  701 VTTF----SFDIFGLELYVPLARGAS---MLLASREQA-----QDPEALLDLVERQGVTVLQATPATWRMLCDS---ERV 765
Cdd:PRK12492   251 QPLMkegqEVMIAPLPLYHIYAFTANcmcMMVSGNHNVlitnpRDIPGFIKELGKWRFSALLGLNTLFVALMDHpgfKDL 330

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  766 DLLRGCTLLCGGEALAEDLAARMRGLSASTW-NLYGPTETTIWSARFRLGEEAR-PFLGGPLENTALYILDSEMNPCPPG 843
Cdd:PRK12492   331 DFSALKLTNSGGTALVKATAERWEQLTGCTIvEGYGLTETSPVASTNPYGELARlGTVGIPVPGTALKVIDDDGNELPLG 410

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  844 VAGELLIGGDGLARGYHRRPGLTAErflpdpfAADGSRLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRL 923
Cdd:PRK12492   411 ERGELCIKGPQVMKGYWQQPEATAE-------ALDAEGWFKTGDIAVIDPDGFVRIVDRKKDLIIVSGFNVYPNEIEDVV 483

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  924 LEQDSVREAVVVAQPG-VAGPTLVAYLVPTEAALvdaesaRQQELRSALKNSLLAvlpdYMVPAHMLLLENLPLTPNGKI 1002
Cdd:PRK12492   484 MAHPKVANCAAIGVPDeRSGEAVKLFVVARDPGL------SVEELKAYCKENFTG----YKVPKHIVLRDSLPMTPVGKI 553


                   ....*
gi 2183974163 1003 NRKAL 1007
Cdd:PRK12492   554 LRREL 558

PtmA

cd17636

long-chain fatty acid CoA ligase (FadD); This family contains fatty acid CoA ligases, ...

1716-2067

5.06e-21

long-chain fatty acid CoA ligase (FadD); This family contains fatty acid CoA ligases, including acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II, most of which are yet to be characterized. Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.

Pssm-ID: 341291 [Multi-domain] Cd Length: 331 Bit Score: 96.99 E-value: 5.06e-21

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1716 VIYTSGSTGKPKGTLLPHGNVL----RLFDATRHWFGFSADDAWSLFHSYAFDFSVweifGALLHGGRLVIVPyetSRSP 1791
Cdd:cd17636      5 AIYTAAFSGRPNGALLSHQALLaqalVLAVLQAIDEGTVFLNSGPLFHIGTLMFTL----ATFHAGGTNVFVR---RVDA 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1792 EDFLRLLCRERVTVLNQTPSAFKQLMQVACAGqevpPLALRHVVFGGEALEVQALRP-WFERFGdRAPRLvnmYGITETT 1870
Cdd:cd17636     78 EEVLELIEAERCTHAFLLPPTIDQIVELNADG----LYDLSSLRSSPAAPEWNDMATvDTSPWG-RKPGG---YGQTEVM 149

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1871 VHVTYrplslADLDGGAASPIGEPIPDLSWYLLDAGLNPVPRGCIGELYVGGAGLARGYLNRPELSCTRFVadpfsttgG 1950
Cdd:cd17636    150 GLATF-----AALGGGAIGGAGRPSPLVQVRILDEDGREVPDGEVGEIVARGPTVMAGYWNRPEVNARRTR--------G 216

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1951 RLYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVVLPHEGPGATQLVGYVVT--QAAPSDP 2028
Cdd:cd17636    217 GWHHTNDLGRREPDGSLSFVGPKTRMIKSGAENIYPAEVERCLRQHPAVADAAVIGVPDPRWAQSVKAIVVlkPGASVTE 296

                          330       340       350
                   ....*....|....*....|....*....|....*....
gi 2183974163 2029 AALRDTLRQALkASLPEhmvPAHLLFLERLPLTANGKLD 2067
Cdd:cd17636    297 AELIEHCRARI-ASYKK---PKSVEFADALPRTAGGADD 331

LC_FACS_bac

cd05932

Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter ...

534-1007

7.53e-21

Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase; The members of this family are bacterial long-chain fatty acid CoA synthetase. Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase in this family is involved in the synthesis of isoprenoid wax ester storage compounds when grown on phytol as the sole carbon source. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.

Pssm-ID: 341255 [Multi-domain] Cd Length: 508 Bit Score: 99.47 E-value: 7.53e-21

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  534 ERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQYMIDDSGLRLLL- 612
Cdd:cd05932      5 VEFTWGEVADKARRLAAALRALGLEPGSKIALISKNCAEWFITDLAIWMAGHISVPLYPTLNPDTIRYVLEHSESKALFv 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  613 -------SQQSVLArlpqsDGLQSLLL---------DDLERLVHGYPAENPDLPEAPDSLCYAIYTSGSTGQPKGVMVRH 676
Cdd:cd05932     85 gklddwkAMAPGVP-----EGLISISLpppsaancqYQWDDLIAQHPPLEERPTRFPEQLATLIYTSGTTGQPKGVMLTF 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  677 RALTNFVCSIARQPGMLARDRLLSvttfsfdifglelYVPLARGASML------LASREQAQDPEALLDLVE---RQGVT 747
Cdd:cd05932    160 GSFAWAAQAGIEHIGTEENDRMLS-------------YLPLAHVTERVfveggsLYGGVLVAFAESLDTFVEdvqRARPT 226

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  748 VLQATPATWRML-------CDSERVDLL--------------------RGCTLLCGGEA-LAEDLAARMRGLSASTWNLY 799
Cdd:cd05932    227 LFFSVPRLWTKFqqgvqdkIPQQKLNLLlkipvvnslvkrkvlkglglDQCRLAGCGSApVPPALLEWYRSLGLNILEAY 306

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  800 GPTETTIWSARFRLGEEARPFLGGPLENTALYILDSemnpcppgvaGELLIGGDGLARGYHRRPGLTAERFLPDPFaadg 879
Cdd:cd05932    307 GMTENFAYSHLNYPGRDKIGTVGNAGPGVEVRISED----------GEILVRSPALMMGYYKDPEATAEAFTADGF---- 372

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  880 srlYRTGDLARYRADGVIEYLGRIDHQVKI-RGFRIELGEIETRLLEQDSVrEAVVVAQPGVAGPtlVAYLVPTEAALVD 958
Cdd:cd05932    373 ---LRTGDKGELDADGNLTITGRVKDIFKTsKGKYVAPAPIENKLAEHDRV-EMVCVIGSGLPAP--LALVVLSEEARLR 446

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  959 AESARQQELRSALKNSLLAVLPDymVPAHMLL-----------LENLPLTPNGKINRKAL 1007
Cdd:cd05932    447 ADAFARAELEASLRAHLARVNST--LDSHEQLagivvvkdpwsIDNGILTPTLKIKRNVL 504

PRK12316

peptide synthase; Provisional

56-521

7.56e-21

peptide synthase; Provisional

Pssm-ID: 237054 [Multi-domain] Cd Length: 5163 Bit Score: 101.96 E-value: 7.56e-21

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163   56 RQWFLWQMDPQSAAYNIPSALRLRGELDVEALSASLGAIVERHQSLRTVFVEDeqlDGFRQQVLASvDVPVPVTLAGDDD 135
Cdd:PRK12316  1107 QRWFFEQAIPQRQHWNQSLLLQARQPLDPDRLGRALERLVAHHDALRLRFREE---DGGWQQAYAA-PQAGEVLWQRQAA 1182

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  136 AQAQIRAFVEsETQQPFDLRNGPLLRARLLRLAADDHVLTLTIHHVAADGWSMRVLVEELIALYgarrqgiEATLPDLPI 215
Cdd:PRK12316  1183 SEEELLALCE-EAQRSLDLEQGPLLRALLVDMADGSQRLLLVIHHLVVDGVSWRILLEDLQRAY-------ADLDADLPA 1254

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  216 QYADYAIWQRHWLE-AGERERQLEYWMARLGGGQSvlELPTDRQRPALPSYRGARHELQLPQALGRQLQALAQRE-GTTL 293
Cdd:PRK12316  1255 RTSSYQAWARRLHEhAGARAEELDYWQAQLEDAPH--ELPCENPDGALENRHERKLELRLDAERTRQLLQEAPAAyRTQV 1332

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  294 FMLLLASFQALLHRYSGQDEIRVGVPVANR----NRVETERLIGFFVNTQVLR----ADLDAQMPFLDllQQTRVA---A 362
Cdd:PRK12316  1333 NDLLLTALARVTCRWSGQASVLVQLEGHGRedlfEDIDLSRTVGWFTSLFPVRltpaADLGESIKAIK--EQLRAVpdkG 1410

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  363 LGAQSHQDLPFEQLVEAL----QPERSLSHSPLFQAMYNHQNLGSAGRQSL-AAQLPG------LSVEDLSWGAHsaqfd 431
Cdd:PRK12316  1411 IGYGLLRYLAGEEAAARLaalpQPRITFNYLGQFDRQFDEAALFVPATESAgAAQDPCaplanwLSIEGQVYGGE----- 1485

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  432 ltldtyeseqgVHAEFTYATDLFEAATVERLARHWRNLLEAVV----AEPRRRL--GDLPLldAEERATLLQRSRLPASE 505
Cdd:PRK12316  1486 -----------LSLHWSFSREMFAEATVQRLADDYARELQALIehccDERNRGVtpSDFPL--AGLSQAQLDALPLPAGE 1552

                          490       500
                   ....*....|....*....|....*
gi 2183974163  506 Y-------PAGQGV--HRLFEAQAG 521
Cdd:PRK12316  1553 IadiyplsPMQQGMlfHSLYEQEAG 1577

starter-C_NRPS

Starter Condensation domains, found in the first module of nonribosomal peptide synthetases ...

2638-2977

7.96e-21

Pssm-ID: 380456 [Multi-domain] Cd Length: 419 Bit Score: 98.21 E-value: 7.96e-21

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2638 YPLSPMQQGMLFHSLYQQNSGDYINQMRLDVEG-LDPQRFREAWQAALDAHEVLRSGFlwQGALEKPLQLVRKRVEVPFS 2716
Cdd:cd19533      2 LPLTSAQRGVWFAEQLDPEGSIYNLAEYLEITGpVDLAVLERALRQVIAEAETLRLRF--TEEEGEPYQWIDPYTPVPIR 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2717 VHDWRDRADLAEALDALAAGEAGLGFELAEAPLLRLVLVRTGERRHHLIYTNHHILMDGWSNSQLLGEVLQRYRG----- 2791
Cdd:cd19533     80 HIDLSGDPDPEGAAQQWMQEDLRKPLPLDNDPLFRHALFTLGDNRHFWYQRVHHIVMDGFSFALFGQRVAEIYTAllkgr 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2792 ETPSRSDGRYRDYI-AWLQRQDAGRTE---AFWKQRLQRLGEPTLLVPAFAHGVRGAEGHADRyrqLDVTTSQRLAEFAR 2867
Cdd:cd19533    160 PAPPAPFGSFLDLVeEEQAYRQSERFErdrAFWTEQFEDLPEPVSLARRAPGRSLAFLRRTAE---LPPELTRTLLEAAE 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2868 EQKVTLNTLVQAAWLILLQRFTGQDTVAFGATVSGRPAelRGIEEQIGLFINTLPVVASPCPEQPIGDWLQAVQGENLAL 2947
Cdd:cd19533    237 AHGASWPSFFIALVAAYLHRLTGANDVVLGVPVMGRLG--AAARQTPGMVANTLPLRLTVDPQQTFAELVAQVSRELRSL 314

                          330       340       350
                   ....*....|....*....|....*....|....*
gi 2183974163 2948 REFEHTPLYDIQRWAGQVGEA--LFD---NILVFE 2977
Cdd:cd19533    315 LRHQRYRYEDLRRDLGLTGELhpLFGptvNYMPFD 349

Cyc_NRPS

Cyc (heterocyclization) domain of nonribosomal peptide synthetases (NRPSs); belongs to the ...

2202-2487

8.13e-21

Pssm-ID: 380458 [Multi-domain] Cd Length: 423 Bit Score: 98.33 E-value: 8.13e-21

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2202 GQALDGTLLETALQALLAHHDALRLGFrLEDGTWRaehraVEAgEVLLWQQSVADG---------QALEALAEQV-QRSL 2271
Cdd:cd19535     34 GEDLDPDRLERAWNKLIARHPMLRAVF-LDDGTQQ-----ILP-EVPWYGITVHDLrglseeeaeAALEELRERLsHRVL 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2272 DLGSGPLLRALLATLGDGSQRLLLVIHHLVVDGVSWRILLEDLQTAYRQLQAgqavALPAKTSAFKAWAERLQAHaRDGG 2351
Cdd:cd19535    107 DVERGPLFDIRLSLLPEGRTRLHLSIDLLVADALSLQILLRELAALYEDPGE----PLPPLELSFRDYLLAEQAL-RETA 181

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2352 LEGERGYWLAQLEgvstELP--------CDdregAQSVRHVRSARTELT-EEATRRLLQEAPAAYRTQVNDLLLTALARV 2422
Cdd:cd19535    182 YERARAYWQERLP----TLPpapqlplaKD----PEEIKEPRFTRREHRlSAEQWQRLKERARQHGVTPSMVLLTAYAEV 253

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2183974163 2423 IGRWTGQADTLIQLEGHGREELFEDIDltRTVGWFTSLFPL--RLSPVAELGASIKRIKEQL-RAIPH 2487
Cdd:cd19535    254 LARWSGQPRFLLNLTLFNRLPLHPDVN--DVVGDFTSLLLLevDGSEGQSFLERARRLQQQLwEDLDH 319

PRK13390

acyl-CoA synthetase; Provisional

506-1007

1.03e-20

acyl-CoA synthetase; Provisional

Pssm-ID: 139538 [Multi-domain] Cd Length: 501 Bit Score: 98.93 E-value: 1.03e-20

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  506 YPagqGVHrlfeaqAGLTPDAPALLFGE--ERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKA 583
Cdd:PRK13390     2 YP---GTH------AQIAPDRPAVIVAEtgEQVSYRQLDDDSAALARVLYDAGLRTGDVVALLSDNSPEALVVLWAALRS 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  584 GGAYVPLDPQYPADRLQYMIDDSGLRLLLSQQSVlarlpqsDGLQSLLLDDLE-RLVHG------------YPAENPDLP 650
Cdd:PRK13390    73 GLYITAINHHLTAPEADYIVGDSGARVLVASAAL-------DGLAAKVGADLPlRLSFGgeidgfgsfeaaLAGAGPRLT 145

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  651 EAPdslCYAI--YTSGSTGQPKGVM--VRHRALTnfvcsiarQPGmlarDRLLSVTTFSFDIFGLELY---------VPL 717
Cdd:PRK13390   146 EQP---CGAVmlYSSGTTGFPKGIQpdLPGRDVD--------APG----DPIVAIARAFYDISESDIYyssapiyhaAPL 210

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  718 -------ARGASMLLASREQAQDPealLDLVERQGVTVLQATPATW-RML-CDSE---RVDL--LRGcTLLCGGEALAED 783
Cdd:PRK13390   211 rwcsmvhALGGTVVLAKRFDAQAT---LGHVERYRITVTQMVPTMFvRLLkLDADvrtRYDVssLRA-VIHAAAPCPVDV 286

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  784 LAARMRGLSASTWNLYGPTE----TTIWSARF--RLGEEARPFLGgplentALYILDSEMNPCPPGVAGELLIGGDGLAR 857
Cdd:PRK13390   287 KHAMIDWLGPIVYEYYSSTEahgmTFIDSPDWlaHPGSVGRSVLG------DLHICDDDGNELPAGRIGTVYFERDRLPF 360

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  858 GYHRRPGLTAERFLP-DPFAADgsrlyrTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVA 936
Cdd:PRK13390   361 RYLNDPEKTAAAQHPaHPFWTT------VGDLGSVDEDGYLYLADRKSFMIISGGVNIYPQETENALTMHPAVHDVAVIG 434

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2183974163  937 QPGVAGPTLVAYLVPTEAALVDAEsarqqELRSALKNSLLAVLPDYMVPAHMLLLENLPLTPNGKINRKAL 1007
Cdd:PRK13390   435 VPDPEMGEQVKAVIQLVEGIRGSD-----ELARELIDYTRSRIAHYKAPRSVEFVDELPRTPTGKLVKGLL 500

LC_FACL_like

cd05914

Uncharacterized subfamily of fatty acid CoA ligase (FACL); The members of this family are ...

1587-2068

1.26e-20

Pssm-ID: 341240 [Multi-domain] Cd Length: 463 Bit Score: 98.28 E-value: 1.26e-20

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1587 VVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGYMIEDSGI 1666
Cdd:cd05914      1 LYYGGEPLTYKDLADNIAKFALLLKINGVGTGDRVALMGENRPEWGIAFFAIWTYGAIAVPILAEFTADEVHHILNHSEA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1667 RLLLTqraarerlplgeglpcllldaehewagypeSDPqsavgvDNLAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRHW 1746
Cdd:cd05914     81 KAIFV------------------------------SDE------DDVALINYTSGTTGNSKGVMLTYRNIVSNVDGVKEV 124

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1747 FGFSADDA----WSLFHSY--AFDFSVweifgALLHGGRLVIVpyetSRSPEDFLRLLCRERVTV--------------- 1805
Cdd:cd05914    125 VLLGKGDKilsiLPLHHIYplTFTLLL-----PLLNGAHVVFL----DKIPSAKIIALAFAQVTPtlgvpvplviekifk 195

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1806 ---LNQTPSA-FKQLMQVACAGQEVPPLALRHVV--FGGEALEV----QALRPWFERFgdraprLVNM-------YGITE 1868
Cdd:cd05914    196 mdiIPKLTLKkFKFKLAKKINNRKIRKLAFKKVHeaFGGNIKEFviggAKINPDVEEF------LRTIgfpytigYGMTE 269

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1869 TTVHVTYRPLSLADLDGgaaspIGEPIPDLSWYLLDaglnPVPRGCIGELYVGGAGLARGYLNRPELSCTRFVADPFstt 1948
Cdd:cd05914    270 TAPIISYSPPNRIRLGS-----AGKVIDGVEVRIDS----PDPATGEGEIIVRGPNVMKGYYKNPEATAEAFDKDGW--- 337

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1949 ggrlYRTGDLARYRCDGVVEYVGRIDHQ-VKIRGFRIELGEIEARLLAQPGVAEAVVLPHEGPGATQLVGY-----VVTQ 2022
Cdd:cd05914    338 ----FHTGDLGKIDAEGYLYIRGRKKEMiVLSSGKNIYPEEIEAKINNMPFVLESLVVVQEKKLVALAYIDpdfldVKAL 413

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*..
gi 2183974163 2023 AAPSDPAALRDTLRQALKASLPEH-MVPAHLLFLERLPLTANGKLDR 2068
Cdd:cd05914    414 KQRNIIDAIKWEVRDKVNQKVPNYkKISKVKIVKEEFEKTPKGKIKR 460

FACL_like_1

cd05910

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ...

1592-2046

1.56e-20

Pssm-ID: 341236 [Multi-domain] Cd Length: 457 Bit Score: 97.92 E-value: 1.56e-20

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1592 RALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYpsdrlgymiedsGIRLLLT 1671
Cdd:cd05910      1 SRLSFRELDERSDRIAQGLTAYGIRRGMRAVLMVPPGPDFFALTFALFKAGAVPVLIDPGM------------GRKNLKQ 68

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1672 qraarerlplgeglpCLLldaehewagypESDPQSAVGV---DNLAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRHWFG 1748
Cdd:cd05910     69 ---------------CLQ-----------EAEPDAFIGIpkaDEPAAILFTSGSTGTPKGVVYRHGTFAAQIDALRQLYG 122

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1749 FSADDAwslfhsyafD---FSVWEIFGALLhGGRLVIVPYETSR----SPEDFLRLLCRERVTVLNQTPSAFKQLMQvAC 1821
Cdd:cd05910    123 IRPGEV---------DlatFPLFALFGPAL-GLTSVIPDMDPTRparaDPQKLVGAIRQYGVSIVFGSPALLERVAR-YC 191

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1822 AGQEVPPLALRHVVFGGEALEVqALRPWFERFGDRAPRLVNMYGITE--------------TTVHVTyrplsladlDGGA 1887
Cdd:cd05910    192 AQHGITLPSLRRVLSAGAPVPI-ALAARLRKMLSDEAEILTPYGATEalpvssigsrellaTTTAAT---------SGGA 261

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1888 ASPIGEPIPDLSWYLLDAGLNP---------VPRGCIGELYVGGAGLARGYLNRPELSCTRFVADPfstTGGRLYRTGDL 1958
Cdd:cd05910    262 GTCVGRPIPGVRVRIIEIDDEPiaewddtleLPRGEIGEITVTGPTVTPTYVNRPVATALAKIDDN---SEGFWHRMGDL 338

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1959 ARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVVLPHEGPGATQLVGYVVTQAAPSDPAAlrdTLRQA 2038
Cdd:cd05910    339 GYLDDEGRLWFCGRKAHRVITTGGTLYTEPVERVFNTHPGVRRSALVGVGKPGCQLPVLCVEPLPGTITPRA---RLEQE 415


                   ....*...
gi 2183974163 2039 LKASLPEH 2046
Cdd:cd05910    416 LRALAKDY 423

PLN02574

4-coumarate--CoA ligase-like

1593-2071

1.72e-20

4-coumarate--CoA ligase-like

Pssm-ID: 215312 [Multi-domain] Cd Length: 560 Bit Score: 98.76 E-value: 1.72e-20

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1593 ALDYGELNLRANRLAHRLIE-LGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGYMIEDSGIRLLLT 1671
Cdd:PLN02574    66 SISYSELQPLVKSMAAGLYHvMGVRQGDVVLLLLPNSVYFPVIFLAVLSLGGIVTTMNPSSSLGEIKKRVVDCSVGLAFT 145

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1672 QRAARERLPlGEGLPCLLL-------DAEHEWAGY-------PESDPQSAVGVDNLAYVIYTSGSTGKPKGTLLPHGNVL 1737
Cdd:PLN02574   146 SPENVEKLS-PLGVPVIGVpenydfdSKRIEFPKFyelikedFDFVPKPVIKQDDVAAIMYSSGTTGASKGVVLTHRNLI 224

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1738 RL------FDATRhwFGFSADD-----AWSLFHSYAFDFSVWeifgALLHGGRLVIVPYETSRSpeDFLRLLCRERVTVL 1806
Cdd:PLN02574   225 AMvelfvrFEASQ--YEYPGSDnvylaALPMFHIYGLSLFVV----GLLSLGSTIVVMRRFDAS--DMVKVIDRFKVTHF 296

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1807 NQTPSAFKQLMQVACAGQEVPPLALRHVVFGGEALEVQALRPWFERFgdraPR--LVNMYGITETTVhVTYRPLSLADLD 1884
Cdd:PLN02574   297 PVVPPILMALTKKAKGVCGEVLKSLKQVSCGAAPLSGKFIQDFVQTL----PHvdFIQGYGMTESTA-VGTRGFNTEKLS 371

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1885 ggAASPIGEPIPDLSWYLLD---AGLNPvPRGCiGELYVGGAGLARGYLNRPELSCTRFVADPFsttggrlYRTGDLARY 1961
Cdd:PLN02574   372 --KYSSVGLLAPNMQAKVVDwstGCLLP-PGNC-GELWIQGPGVMKGYLNNPKATQSTIDKDGW-------LRTGDIAYF 440

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1962 RCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVVLPHEGPGATQL-VGYVVTQAApsdpaalrDTLRQALK 2040
Cdd:PLN02574   441 DEDGYLYIVDRLKEIIKYKGFQIAPADLEAVLISHPEIIDAAVTAVPDKECGEIpVAFVVRRQG--------STLSQEAV 512

                          490       500       510
                   ....*....|....*....|....*....|....*.
gi 2183974163 2041 ASLPEHMVPAH-----LLFLERLPLTANGKLDRRAL 2071
Cdd:PLN02574   513 INYVAKQVAPYkkvrkVVFVQSIPKSPAGKILRREL 548

E_NRPS

Epimerization domain of nonribosomal peptide synthetases (NRPSs); belongs to the ...

1121-1533

2.06e-20

Pssm-ID: 380457 [Multi-domain] Cd Length: 428 Bit Score: 96.94 E-value: 2.06e-20

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1121 QWFIWRLDPHSAAYNIPVALRLKGPLRRDALQGALDLLVQRHETLRTTFVEHDGAPRQVIHPtlpiaIEERRPPVAGEDL 1200
Cdd:cd19534      9 RWFFEQNLAGRHHFNQSVLLRVPQGLDPDALRQALRALVEHHDALRMRFRREDGGWQQRIRG-----DVEELFRLEVVDL 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1201 KGLVE--------TEAHRPFDLQRGPLLRVLLLPLATDECVLVLTLHHIIADGWSMQVLVDELIRVYAALRHDQPPALAE 1272
Cdd:cd19534     84 SSLAQaaaiealaAEAQSSLDLEEGPLLAAALFDGTDGGDRLLLVIHHLVVDGVSWRILLEDLEAAYEQALAGEPIPLPS 163

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1273 LPiQYADFAAWQRQWMDGGERERQLDYWVSRLGgeQPLLELPSDRPRPQQQShrgRRIGIPLPAELAEALRRLAQAEQGT 1352
Cdd:cd19534    164 KT-SFQTWAELLAEYAQSPALLEELAYWRELPA--ADYWGLPKDPEQTYGDA---RTVSFTLDEEETEALLQEANAAYRT 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1353 LFM-LLLASFQALLHRYSGQNDIRV-----GvpianrnREE-TEGL-----IGFFVNTQVLRAELDGQLPFRELLRQVRQ 1420
Cdd:cd19534    238 EINdLLLAALALAFQDWTGRAPPAIfleghG-------REEiDPGLdlsrtVGWFTSMYPVVLDLEASEDLGDTLKRVKE 310

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1421 AvVEAQGHQDLPFEQLVDALQPERS-LSHAPLFQVMYN----HQRDDHRGSRFASLGELEVEDLAWDVQ-TAQFDLTldt 1494
Cdd:cd19534    311 Q-LRRIPNKGIGYGILRYLTPEGTKrLAFHPQPEISFNylgqFDQGERDDALFVSAVGGGGSDIGPDTPrFALLDIN--- 386

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|..
gi 2183974163 1495 yeSS--NG-LLAELTYATDLFDASSAERIAGHWLNLLRSIVA 1533
Cdd:cd19534    387 --AVveGGqLVITVSYSRNMYHEETIQQLADSYKEALEALIE 426

FACL_like_5

cd05924

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ...

1711-2069

2.45e-20

Pssm-ID: 341248 [Multi-domain] Cd Length: 364 Bit Score: 95.91 E-value: 2.45e-20

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1711 DNLaYVIYTSGSTGKPKGTLLPHGNVLR-LFDATRHWFGFSADDAWS-----------------LFHSYafdfSVWEIFG 1772
Cdd:cd05924      4 DDL-YILYTGGTTGMPKGVMWRQEDIFRmLMGGADFGTGEFTPSEDAhkaaaaaagtvmfpappLMHGT----GSWTAFG 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1773 ALLHGGRLVIVPYETsrSPEDFLRLLCRERVTVLNQTPSAF-KQLMQVACAGQEVPPLALRHVVFGGEAL--EVQalrpw 1849
Cdd:cd05924     79 GLLGGQTVVLPDDRF--DPEEVWRTIEKHKVTSMTIVGDAMaRPLIDALRDAGPYDLSSLFAISSGGALLspEVK----- 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1850 fERFGDRAPR--LVNMYGITET----TVHVTYRPLSladldggaASPIGEPIPDLSwyLLDAGLNPVPRGCIGELYVGGA 1923
Cdd:cd05924    152 -QGLLELVPNitLVDAFGSSETgftgSGHSAGSGPE--------TGPFTRANPDTV--VLDDDGRVVPPGSGGVGWIARR 220

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1924 GL-ARGYLNRPELSctrfvADPFSTTGG-RLYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAE 2001
Cdd:cd05924    221 GHiPLGYYGDEAKT-----AETFPEVDGvRYAVPGDRATVEADGTVTLLGRGSVCINTGGEKVFPEEVEEALKSHPAVYD 295

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2183974163 2002 AVV--LPHEGPGatQLVGYVVTQAAPSDP--AALRDTLRQalkaSLPEHMVPAHLLFLERLPLTANGKLDRR 2069
Cdd:cd05924    296 VLVvgRPDERWG--QEVVAVVQLREGAGVdlEELREHCRT----RIARYKLPKQVVFVDEIERSPAGKADYR 361

PRK13382

bile acid CoA ligase;

485-1010

2.71e-20

bile acid CoA ligase;

Pssm-ID: 172019 [Multi-domain] Cd Length: 537 Bit Score: 97.91 E-value: 2.71e-20

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  485 PLLDAEERATLLQRSRLPASEYP------------AGQGVHRLFEAQAGLTPDAPALLFGEERLSYAELNALANRLAWRL 552
Cdd:PRK13382     6 RLRDTLGLIATLRRAGLIAPMRPdrylrivaamrrEGMGPTSGFAIAAQRCPDRPGLIDELGTLTWRELDERSDALAAAL 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  553 REEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQYMIDDSGLRLLLSQQSVLARLPQ--------- 623
Cdd:PRK13382    86 QALPIGEPRVVGIMCRNHRGFVEALLAANRIGADILLLNTSFAGPALAEVVTREGVDTVIYDEEFSATVDRaladcpqat 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  624 -----SDGLQSLLLddlERLVHGYPAENPdlPEAPDSLCYAIYTSGSTGQPKGVmvRHRALTNF--VCSIARQPGMLARD 696
Cdd:PRK13382   166 rivawTDEDHDLTV---EVLIAAHAGQRP--EPTGRKGRVILLTSGTTGTPKGA--RRSGPGGIgtLKAILDRTPWRAEE 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  697 RLLSVTTFsFDIFGLELYVPLARGASMLLASREQaqDPEALLDLVERQGVTVLQATPATWRMLCD--SERVDLLRGCTL- 773
Cdd:PRK13382   239 PTVIVAPM-FHAWGFSQLVLAASLACTIVTRRRF--DPEATLDLIDRHRATGLAVVPVMFDRIMDlpAEVRNRYSGRSLr 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  774 --LCGGEALAEDLA-ARMRGLSASTWNLYGPTE----TTIWSARFRlgeeARPFLGG-PLENTALYILDSEMNPCPPGVA 845
Cdd:PRK13382   316 faAASGSRMRPDVViAFMDQFGDVIYNNYNATEagmiATATPADLR----AAPDTAGrPAEGTEIRILDQDFREVPTGEV 391

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  846 GELLIGGDGLARGYhrRPGLTAErfLPDPFAAdgsrlyrTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLE 925
Cdd:PRK13382   392 GTIFVRNDTQFDGY--TSGSTKD--FHDGFMA-------SGDVGYLDENGRLFVVGRDDEMIVSGGENVYPIEVEKTLAT 460

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  926 QDSVREAVVVaqpGVA----GPTLVAYLVPTEAAlvdaeSARQQELRSALKNSLlavlPDYMVPAHMLLLENLPLTPNGK 1001
Cdd:PRK13382   461 HPDVAEAAVI---GVDdeqyGQRLAAFVVLKPGA-----SATPETLKQHVRDNL----ANYKVPRDIVVLDELPRGATGK 528


                   ....*....
gi 2183974163 1002 INRKALPLP 1010
Cdd:PRK13382   529 ILRRELQAR 537

PRK07059

Long-chain-fatty-acid--CoA ligase; Validated

1559-2071

3.70e-20

Long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 235923 [Multi-domain] Cd Length: 557 Bit Score: 97.78 E-value: 3.70e-20

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1559 PGPQDFTPASCLHRLIE---RQAAERPratAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGL 1635
Cdd:PRK07059    14 PAEIDASQYPSLADLLEesfRQYADRP---AFICMGKAITYGELDELSRALAAWLQSRGLAKGARVAIMMPNVLQYPVAI 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1636 LAILKAGGAYVPLDPRYPSDRLGYMIEDSG---IRLL------LTQRAARERLP------LGE--GLPCLLL-------- 1690
Cdd:PRK07059    91 AAVLRAGYVVVNVNPLYTPRELEHQLKDSGaeaIVVLenfattVQQVLAKTAVKhvvvasMGDllGFKGHIVnfvvrrvk 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1691 ---------------DAEHEWAGYPESDPqsAVGVDNLAYVIYTSGSTGKPKGTLLPHGNVLR-----------LFDATR 1744
Cdd:PRK07059   171 kmvpawslpghvrfnDALAEGARQTFKPV--KLGPDDVAFLQYTGGTTGVSKGATLLHRNIVAnvlqmeawlqpAFEKKP 248

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1745 HWFGFSADDAWSLFHSYAFdfSVWEIFGALLhGGRLVIVPyetsrSPED---FLRLLCRERVTVLNQTPSAFKQLMQVAc 1821
Cdd:PRK07059   249 RPDQLNFVCALPLYHIFAL--TVCGLLGMRT-GGRNILIP-----NPRDipgFIKELKKYQVHIFPAVNTLYNALLNNP- 319

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1822 agqEVPPLALRHVVF---GGEALEVQALRPWFERFGdrAPrLVNMYGITETTVHVTYRPLSLADLDGgaasPIGEPIPDL 1898
Cdd:PRK07059   320 ---DFDKLDFSKLIVangGGMAVQRPVAERWLEMTG--CP-ITEGYGLSETSPVATCNPVDATEFSG----TIGLPLPST 389

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1899 SWYLLDAGLNPVPRGCIGELYVGGAGLARGYLNRPELSCTRFVADPFsttggrlYRTGDLARYRCDGVVEYVGRIDHQVK 1978
Cdd:PRK07059   390 EVSIRDDDGNDLPLGEPGEICIRGPQVMAGYWNRPDETAKVMTADGF-------FRTGDVGVMDERGYTKIVDRKKDMIL 462

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1979 IRGFRIELGEIEARLLAQPGVAE--AVVLPHEGPG-ATQLvgYVVTQaapsDPAALRDTLRQALKASLPEHMVPAHLLFL 2055
Cdd:PRK07059   463 VSGFNVYPNEIEEVVASHPGVLEvaAVGVPDEHSGeAVKL--FVVKK----DPALTEEDVKAFCKERLTNYKRPKFVEFR 536

                          570
                   ....*....|....*.
gi 2183974163 2056 ERLPLTANGKLDRRAL 2071
Cdd:PRK07059   537 TELPKTNVGKILRREL 552

PRK13383

acyl-CoA synthetase; Provisional

500-1008

4.16e-20

acyl-CoA synthetase; Provisional

Pssm-ID: 139531 [Multi-domain] Cd Length: 516 Bit Score: 96.99 E-value: 4.16e-20

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  500 RLPASEYPAGQGVHRLFEAQAGLTPDAPALLFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLA 579
Cdd:PRK13383    25 RLLREASRGGTNPYTLLAVTAARWPGRTAIIDDDGALSYRELQRATESLARRLTRDGVAPGRAVGVMCRNGRGFVTAVFA 104

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  580 VLKAGGAYVPLDPQYPADRLQYMIDDSGLRLLLSQQSVLARLPQSDglQSLLLDDlerlvhgyPA-----ENPDLPEAPD 654
Cdd:PRK13383   105 VGLLGADVVPISTEFRSDALAAALRAHHISTVVADNEFAERIAGAD--DAVAVID--------PAtagaeESGGRPAVAA 174

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  655 SLCYAIYTSGSTGQPKGVMVRHRALTNFVCSIArqpgMLARDRL-----LSVTTFSFDIFGL-ELYVPLARGASMLLASR 728
Cdd:PRK13383   175 PGRIVLLTSGTTGKPKGVPRAPQLRSAVGVWVT----ILDRTRLrtgsrISVAMPMFHGLGLgMLMLTIALGGTVLTHRH 250

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  729 EQAQDPEALLDLVERQGVTVLQATPATWRMLCDSERVDLLRGC--TLLCGGEALAEDLAAR-MRGLSASTWNLYGPTETT 805
Cdd:PRK13383   251 FDAEAALAQASLHRADAFTAVPVVLARILELPPRVRARNPLPQlrVVMSSGDRLDPTLGQRfMDTYGDILYNGYGSTEVG 330

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  806 IWS----ARFRLGEEArpfLGGPLENTALYILDSEMNPCPPGVAGELLIGGDGLARGYHRRPGLTaerflpdpfAADGsr 881
Cdd:PRK13383   331 IGAlatpADLRDAPET---VGKPVAGCPVRILDRNNRPVGPRVTGRIFVGGELAGTRYTDGGGKA---------VVDG-- 396

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  882 LYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQPGVA-GPTLVAYLVPTEAALVDAE 960
Cdd:PRK13383   397 MTSTGDMGYLDNAGRLFIVGREDDMIISGGENVYPRAVENALAAHPAVADNAVIGVPDERfGHRLAAFVVLHPGSGVDAA 476

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*...
gi 2183974163  961 sarqqELRSALKNSllavLPDYMVPAHMLLLENLPLTPNGKINRKALP 1008
Cdd:PRK13383   477 -----QLRDYLKDR----VSRFEQPRDINIVSSIPRNPTGKVLRKELP 515

PRK08974

long-chain-fatty-acid--CoA ligase FadD;

1711-2071

5.25e-20

long-chain-fatty-acid--CoA ligase FadD;

Pssm-ID: 236359 [Multi-domain] Cd Length: 560 Bit Score: 97.05 E-value: 5.25e-20

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1711 DNLAYVIYTSGSTGKPKGTLLPHGNVL-RLFDATRHWFGFSADD------AWSLFHSYAFDFSvweifgALLH---GGRL 1780
Cdd:PRK08974   206 EDLAFLQYTGGTTGVAKGAMLTHRNMLaNLEQAKAAYGPLLHPGkelvvtALPLYHIFALTVN------CLLFielGGQN 279

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1781 VIVPyetsrSPED---FLRLLCRERVTVLNQTPSAFKQLMQVAcAGQEVPPLALRHVVFGGEALEVQALRPWFERFGDRa 1857
Cdd:PRK08974   280 LLIT-----NPRDipgFVKELKKYPFTAITGVNTLFNALLNNE-EFQELDFSSLKLSVGGGMAVQQAVAERWVKLTGQY- 352

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1858 prLVNMYGITETTVHVTYRPLSLADLDGGaaspIGEPIPDLSWYLLDAGLNPVPRGCIGELYVGGAGLARGYLNRPElSC 1937
Cdd:PRK08974   353 --LLEGYGLTECSPLVSVNPYDLDYYSGS----IGLPVPSTEIKLVDDDGNEVPPGEPGELWVKGPQVMLGYWQRPE-AT 425

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1938 TRFVADpfsttgGRLyRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAE--AVVLPHEGPGATQL 2015
Cdd:PRK08974   426 DEVIKD------GWL-ATGDIAVMDEEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMLHPKVLEvaAVGVPSEVSGEAVK 498

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2183974163 2016 VgYVVtqaaPSDPAALRDTLRQALKASLPEHMVPAHLLFLERLPLTANGKLDRRAL 2071
Cdd:PRK08974   499 I-FVV----KKDPSLTEEELITHCRRHLTGYKVPKLVEFRDELPKSNVGKILRREL 549

ACLS-CaiC

cd17637

acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; This family contains fatty acid CoA ...

660-1004

6.59e-20

Pssm-ID: 341292 [Multi-domain] Cd Length: 333 Bit Score: 93.87 E-value: 6.59e-20

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  660 IYTSGSTGQPKGVMVRHRaltNFVCS---IARQPGMLARDRLLSVTTFsFDIFGLEL-YVPLARGASMLLASReqaQDPE 735
Cdd:cd17637      6 IHTAAVAGRPRGAVLSHG---NLIAAnlqLIHAMGLTEADVYLNMLPL-FHIAGLNLaLATFHAGGANVVMEK---FDPA 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  736 ALLDLVERQGVTVLQATPATWRMLCDSER---VDL--LRGCTllcGGEAlaEDLAARMRGLSAST-WNLYGPTET----T 805
Cdd:cd17637     79 EALELIEEEKVTLMGSFPPILSNLLDAAEksgVDLssLRHVL---GLDA--PETIQRFEETTGATfWSLYGQTETsglvT 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  806 IWSARFRLGEEARPflgGPLENTAlyILDSEMNPCPPGVAGELLIGGDGLARGYHRRPGLTAERFlpdpfaADGsrLYRT 885
Cdd:cd17637    154 LSPYRERPGSAGRP---GPLVRVR--IVDDNDRPVPAGETGEIVVRGPLVFQGYWNLPELTAYTF------RNG--WHHT 220

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  886 GDLARYRADGVIEYLGRIDHQ--VKIRGFRIELGEIETRLLEQDSVREAVVVaqpGVAGP----------TLVAYLVPTE 953
Cdd:cd17637    221 GDLGRFDEDGYLWYAGRKPEKelIKPGGENVYPAEVEKVILEHPAIAEVCVI---GVPDPkwgegikavcVLKPGATLTA 297

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2183974163  954 AALVDAESARqqelrsalknsllavLPDYMVPAHMLLLENLPLTPNGKINR 1004
Cdd:cd17637    298 DELIEFVGSR---------------IARYKKPRYVVFVEALPKTADGSIDR 333

LCL_NRPS-like

LCL-type Condensation domain of nonribosomal peptide synthetases (NRPSs) and similar domains; ...

2639-2922

1.43e-19

Pssm-ID: 380463 [Multi-domain] Cd Length: 433 Bit Score: 94.41 E-value: 1.43e-19

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2639 PLSPMQQGMLFHSLYQQNSGDYINQMRLDVEG-LDPQRFREAWQAALDAHEVLRSGFlwQGALEKPLQLVR--KRVEVPF 2715
Cdd:cd19540      3 PLSFAQQRLWFLNRLDGPSAAYNIPLALRLTGaLDVDALRAALADVVARHESLRTVF--PEDDGGPYQVVLpaAEARPDL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2716 SVHDwrdraDLAEALDALAAGEAGLGFELAEAPLLRLVLVRTGERRHHLIYTNHHILMDGWSNSQLLGEVLQRYRgetpS 2795
Cdd:cd19540     81 TVVD-----VTEDELAARLAEAARRGFDLTAELPLRARLFRLGPDEHVLVLVVHHIAADGWSMAPLARDLATAYA----A 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2796 RSDGR----------YRDYIAWlQRQ----------DAGRTEAFWKQRLQRLGEPTLLV-----PAFAHGvRGAEGHADr 2850
Cdd:cd19540    152 RRAGRapdwaplpvqYADYALW-QREllgdeddpdsLAARQLAYWRETLAGLPEELELPtdrprPAVASY-RGGTVEFT- 228

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2183974163 2851 yrqLDVTTSQRLAEFAREQKVTLNTLVQAAWLILLQRFTGQDTVAFGATVSGRPAElrGIEEQIGLFINTLP 2922
Cdd:cd19540    229 ---IDAELHARLAALAREHGATLFMVLHAALAVLLSRLGAGDDIPIGTPVAGRGDE--ALDDLVGMFVNTLV 295

Cyc_NRPS

Cyc (heterocyclization) domain of nonribosomal peptide synthetases (NRPSs); belongs to the ...

1149-1431

1.82e-19

Pssm-ID: 380458 [Multi-domain] Cd Length: 423 Bit Score: 94.09 E-value: 1.82e-19

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1149 DALQGALDLLVQRHETLRTTFVEhDGapRQVIHPTLPiaieerRPPVAGEDLKGLVETEA------------HRPFDLQR 1216
Cdd:cd19535     40 DRLERAWNKLIARHPMLRAVFLD-DG--TQQILPEVP------WYGITVHDLRGLSEEEAeaaleelrerlsHRVLDVER 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1217 GPLLRVLLLPLATDECVLVLTLHHIIADGWSMQVLVDELIRVYaalrHDQPPALAELPIQYADFAAWQRQwMDGGERERQ 1296
Cdd:cd19535    111 GPLFDIRLSLLPEGRTRLHLSIDLLVADALSLQILLRELAALY----EDPGEPLPPLELSFRDYLLAEQA-LRETAYERA 185

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1297 LDYWVSRL----GGEQ-PLLELPSDRPRPQQQSHRGRrigipLPAELAEALRRLAQAEQGTLFMLLLASFQALLHRYSGQ 1371
Cdd:cd19535    186 RAYWQERLptlpPAPQlPLAKDPEEIKEPRFTRREHR-----LSAEQWQRLKERARQHGVTPSMVLLTAYAEVLARWSGQ 260

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2183974163 1372 NDIRVGVPIANRNR--EETEGLIGFFVNTQVLRAELDGQLPFRELLRQVRQavveaQGHQDL 1431
Cdd:cd19535    261 PRFLLNLTLFNRLPlhPDVNDVVGDFTSLLLLEVDGSEGQSFLERARRLQQ-----QLWEDL 317

FadD3

cd17638

acyl-CoA synthetase FadD3 and similar proteins; This family contains long chain fatty acid CoA ...

1712-2066

2.08e-19

acyl-CoA synthetase FadD3 and similar proteins; This family contains long chain fatty acid CoA ligases, including FadD3 which is an acyl-CoA synthetase that initiates catabolism of cholesterol rings C and D in actinobacteria. The cholesterol catabolic pathway occurs in most mycolic acid-containing actinobacteria, such as Rhodococcus jostii RHA1, and is critical for Mycobacterium tuberculosis (Mtb) during infection. FadD3 catalyzes the ATP-dependent CoA thioesterification of 3a-alpha-H-4alpha(3'-propanoate)-7a-beta-methylhexahydro-1,5-indanedione (HIP) to yield HIP-CoA. Hydroxylated analogs of HIP, 5alpha-OH HIP and 1beta-OH HIP, can also be used.

Pssm-ID: 341293 [Multi-domain] Cd Length: 330 Bit Score: 92.18 E-value: 2.08e-19

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1712 NLAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRHWFGFSADDAW----SLFHSYAFDFSvweIFGALLHGGrlVIVPYET 1787
Cdd:cd17638      1 DVSDIMFTSGTTGRSKGVMCAHRQTLRAAAAWADCADLTEDDRYliinPFFHTFGYKAG---IVACLLTGA--TVVPVAV 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1788 SrSPEDFLRLLCRERVTVLNQTPSAFKQLMQVAcAGQEVPPLALRHVVFGGEALEVQALRPWFERFGDRAprLVNMYGIT 1867
Cdd:cd17638     76 F-DVDAILEAIERERITVLPGPPTLFQSLLDHP-GRKKFDLSSLRAAVTGAATVPVELVRRMRSELGFET--VLTAYGLT 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1868 ETTVHVTYRPLSLADLdggAASPIGEPIPDLSWYLLDAglnpvprgciGELYVGGAGLARGYLNRPELSCTRFVADpfst 1947
Cdd:cd17638    152 EAGVATMCRPGDDAET---VATTCGRACPGFEVRIADD----------GEVLVRGYNVMQGYLDDPEATAEAIDAD---- 214

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1948 tgGRLYrTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVVL--PHEGPGAtqlVG--YVVTQa 2023
Cdd:cd17638    215 --GWLH-TGDVGELDERGYLRITDRLKDMYIVGGFNVYPAEVEGALAEHPGVAQVAVIgvPDERMGE---VGkaFVVAR- 287

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*..
gi 2183974163 2024 apsDPAALRDtlrQALKASLPEHM----VPAHLLFLERLPLTANGKL 2066
Cdd:cd17638    288 ---PGVTLTE---EDVIAWCRERLanykVPRFVRFLDELPRNASGKV 328

PRK09029

O-succinylbenzoic acid--CoA ligase; Provisional

520-935

2.43e-19

O-succinylbenzoic acid--CoA ligase; Provisional

Pssm-ID: 236363 [Multi-domain] Cd Length: 458 Bit Score: 94.17 E-value: 2.43e-19

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  520 AGLTPDAPALLFGEERLSYAELNALANRLAWRLREEGVGSDvlVGIALeRG---VPMVVALLAVLKAGGAYVPLDPQYPA 596
Cdd:PRK09029    13 AQVRPQAIALRLNDEVLTWQQLCARIDQLAAGFAQQGVVEG--SGVAL-RGknsPETLLAYLALLQCGARVLPLNPQLPQ 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  597 DRLQYMIDDSGLRLLLsqqsVLARLPQSDGLQSLLLDdlerlvhgYPAENPDLPEAPDSLCYAIYTSGSTGQPKGVMVRH 676
Cdd:PRK09029    90 PLLEELLPSLTLDFAL----VLEGENTFSALTSLHLQ--------LVEGAHAVAWQPQRLATMTLTSGSTGLPKAAVHTA 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  677 RA-LTNfvcsiarqpgmlARDrLLSVTTFS-----------FDIFGLE-LYVPLARGASMLLasREQAQDPEALldlver 743
Cdd:PRK09029   158 QAhLAS------------AEG-VLSLMPFTaqdswllslplFHVSGQGiVWRWLYAGATLVV--RDKQPLEQAL------ 216

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  744 QGVT--VLQATPAtWRMLCDSERVDLLRgcTLLCGGEALAEDLAARMRGLSASTWNLYGPTE--TTIWSARfrlgEEARP 819
Cdd:PRK09029   217 AGCThaSLVPTQL-WRLLDNRSEPLSLK--AVLLGGAAIPVELTEQAEQQGIRCWCGYGLTEmaSTVCAKR----ADGLA 289

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  820 FLGGPLENTALYIldsemnpcppgVAGELLIGGDGLARGYHRRPGLTaerflpdPFA-ADGsrLYRTGDLARYRaDGVIE 898
Cdd:PRK09029   290 GVGSPLPGREVKL-----------VDGEIWLRGASLALGYWRQGQLV-------PLVnDEG--WFATRDRGEWQ-NGELT 348

                          410       420       430
                   ....*....|....*....|....*....|....*..
gi 2183974163  899 YLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVV 935
Cdd:PRK09029   349 ILGRLDNLFFSGGEGIQPEEIERVINQHPLVQQVFVV 385

FATP_FACS

cd05940

Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its ...

1591-2065

5.05e-19

Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Fatty acid transport protein (FATP) transports long-chain or very-long-chain fatty acids across the plasma membrane. FATPs also have fatty acid CoA synthetase activity, thus playing dual roles as fatty acid transporters and its activation enzymes. At least five copies of FATPs are identified in mammalian cells. This family also includes prokaryotic FATPs. FATPs are the key players in the trafficking of exogenous fatty acids into the cell and in intracellular fatty acid homeostasis.

Pssm-ID: 341263 [Multi-domain] Cd Length: 449 Bit Score: 93.19 E-value: 5.05e-19

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1591 ERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAyvpldprypsdrlGYMIEdsgirllL 1670
Cdd:cd05940      1 DEALTYAELDAMANRYARWLKSLGLKPGDVVALFMENRPEYVLLWLGLVKIGAV-------------AALIN-------Y 60

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1671 TQRaarerlplGEGLP-CL-LLDAEHewagypesdpqsaVGVDnLAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRHWFG 1748
Cdd:cd05940     61 NLR--------GESLAhCLnVSSAKH-------------LVVD-AALYIYTSGTTGLPKAAIISHRRAWRGGAFFAGSGG 118

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1749 FSADD----AWSLFHSYAfdfSVWEIFGALLHGGRLVIvpyETSRSPEDFLRLLCRERVTV-----------LNQTPSAF 1813
Cdd:cd05940    119 ALPSDvlytCLPLYHSTA---LIVGWSACLASGATLVI---RKKFSASNFWDDIRKYQATIfqyigelcrylLNQPPKPT 192

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1814 KQLMQVACagqevpplalrhvVFGgealevQALRP--W--F-ERFGDraPRLVNMYGITETTVhvtyrplSLADLDG--- 1885
Cdd:cd05940    193 ERKHKVRM-------------IFG------NGLRPdiWeeFkERFGV--PRIAEFYAATEGNS-------GFINFFGkpg 244

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1886 --GAASPI----------------GEPIPDLSWYLLdaglnPVPRGCIGEL--YVGGAGLARGYLNrPELSCTRFVADPF 1945
Cdd:cd05940    245 aiGRNPSLlrkvaplalvkydlesGEPIRDAEGRCI-----KVPRGEPGLLisRINPLEPFDGYTD-PAATEKKILRDVF 318

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1946 StTGGRLYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVVLPHEGPGATQLVGY---VVTQ 2022
Cdd:cd05940    319 K-KGDAWFNTGDLMRLDGEGFWYFVDRLGDTFRWKGENVSTTEVAAVLGAFPGVEEANVYGVQVPGTDGRAGMaaiVLQP 397

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|...
gi 2183974163 2023 AAPSDPAALRDTLRQAlkasLPEHMVPAHLLFLERLPLTANGK 2065
Cdd:cd05940    398 NEEFDLSALAAHLEKN----LPGYARPLFLRLQPEMEITGTFK 436

PRK08315

AMP-binding domain protein; Validated

514-1002

8.60e-19

AMP-binding domain protein; Validated

Pssm-ID: 236236 [Multi-domain] Cd Length: 559 Bit Score: 93.34 E-value: 8.60e-19

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  514 RLFEAQAGLTPDAPALLFGEE--RLSYAELNALANRLAWRLREEGVGSDVLVGI-ALERgVPMVVALLAVLKAGGAYVPL 590
Cdd:PRK08315    20 QLLDRTAARYPDREALVYRDQglRWTYREFNEEVDALAKGLLALGIEKGDRVGIwAPNV-PEWVLTQFATAKIGAILVTI 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  591 DPQYPADRLQYMIDDSGLRLLLSQ------------QSVLARLPQSD--GLQSLLLDDLERLVH---------------- 640
Cdd:PRK08315    99 NPAYRLSELEYALNQSGCKALIAAdgfkdsdyvamlYELAPELATCEpgQLQSARLPELRRVIFlgdekhpgmlnfdell 178

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  641 --GYPAENPDLPEAPDSL-CY-AI---YTSGSTGQPKGVMVRHRALTNFVCSIARQPGMLARDRLLSVTTFsFDIFGLEL 713
Cdd:PRK08315   179 alGRAVDDAELAARQATLdPDdPIniqYTSGTTGFPKGATLTHRNILNNGYFIGEAMKLTEEDRLCIPVPL-YHCFGMVL 257

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  714 YV--PLARGASMLLASreQAQDPEALLDLVERQGVTVLQATPAtwrM------LCDSERVDL--LRgcTLLCGGEALAED 783
Cdd:PRK08315   258 GNlaCVTHGATMVYPG--EGFDPLATLAAVEEERCTALYGVPT---MfiaeldHPDFARFDLssLR--TGIMAGSPCPIE 330

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  784 LAAR------MRGLSAStwnlYGPTETTIWSARFRLGEearPF------LGGPLENTALYILDSEMN-PCPPGVAGELLI 850
Cdd:PRK08315   331 VMKRvidkmhMSEVTIA----YGMTETSPVSTQTRTDD---PLekrvttVGRALPHLEVKIVDPETGeTVPRGEQGELCT 403

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  851 GGDGLARGYHRRPGLTAErflpdpfAADGSRLYRTGDLARYRADGVIEYLGRIDHQVkIRGfrielG------EIETRLL 924
Cdd:PRK08315   404 RGYSVMKGYWNDPEKTAE-------AIDADGWMHTGDLAVMDEEGYVNIVGRIKDMI-IRG-----GeniyprEIEEFLY 470

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  925 EQDSVREAVVVaqpGVA----GPTLVAYLVPTEAALVDAEsarqqELRSALKNSllavLPDYMVPAHMLLLENLPLTPNG 1000
Cdd:PRK08315   471 THPKIQDVQVV---GVPdekyGEEVCAWIILRPGATLTEE-----DVRDFCRGK----IAHYKIPRYIRFVDEFPMTVTG 538


                   ..
gi 2183974163 1001 KI 1002
Cdd:PRK08315   539 KI 540

PRK07059

Long-chain-fatty-acid--CoA ligase; Validated

501-1007

9.49e-19

Long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 235923 [Multi-domain] Cd Length: 557 Bit Score: 93.16 E-value: 9.49e-19

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  501 LPASEYPAgqgVHRLFEAQAGLTPDAPALLFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAV 580
Cdd:PRK07059    17 IDASQYPS---LADLLEESFRQYADRPAFICMGKAITYGELDELSRALAAWLQSRGLAKGARVAIMMPNVLQYPVAIAAV 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  581 LKAGGAYVPLDPQYPADRLQYMIDDSGLRLLL-------SQQSVLARLP--------QSD--GLQSLLLDDLERLVH--- 640
Cdd:PRK07059    94 LRAGYVVVNVNPLYTPRELEHQLKDSGAEAIVvlenfatTVQQVLAKTAvkhvvvasMGDllGFKGHIVNFVVRRVKkmv 173

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  641 ------GYPAENPDLPE-----------APDSLCYAIYTSGSTGQPKGVMVRHRaltNFVCSIAR-----QPGMLARDRL 698
Cdd:PRK07059   174 pawslpGHVRFNDALAEgarqtfkpvklGPDDVAFLQYTGGTTGVSKGATLLHR---NIVANVLQmeawlQPAFEKKPRP 250

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  699 LSVTTfsfdIFGLELYVPLARGASMLLASREQA--------QDPEALLDLVERQGVTVLQATPATWRMLCDSE---RVDL 767
Cdd:PRK07059   251 DQLNF----VCALPLYHIFALTVCGLLGMRTGGrnilipnpRDIPGFIKELKKYQVHIFPAVNTLYNALLNNPdfdKLDF 326

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  768 LRGCTLLCGGEALAEDLAARMR-----------GLSAS----TWNlygPTETTIWSARfrlgeearpfLGGPLENTALYI 832
Cdd:PRK07059   327 SKLIVANGGGMAVQRPVAERWLemtgcpitegyGLSETspvaTCN---PVDATEFSGT----------IGLPLPSTEVSI 393

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  833 LDSEMNPCPPGVAGELLIGGDGLARGYHRRPGLTAERFLPDPFaadgsrlYRTGDLARYRADGVIEYLGRIDHQVKIRGF 912
Cdd:PRK07059   394 RDDDGNDLPLGEPGEICIRGPQVMAGYWNRPDETAKVMTADGF-------FRTGDVGVMDERGYTKIVDRKKDMILVSGF 466

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  913 RIELGEIETRLLEQDSVREAVVVAQPGV-AGPTLVAYLVPTEAALVDAEsarqqelrsaLKNSLLAVLPDYMVPAHMLLL 991
Cdd:PRK07059   467 NVYPNEIEEVVASHPGVLEVAAVGVPDEhSGEAVKLFVVKKDPALTEED----------VKAFCKERLTNYKRPKFVEFR 536

                          570
                   ....*....|....*.
gi 2183974163  992 ENLPLTPNGKINRKAL 1007
Cdd:PRK07059   537 TELPKTNVGKILRREL 552

FadD3

cd17638

acyl-CoA synthetase FadD3 and similar proteins; This family contains long chain fatty acid CoA ...

660-1002

1.01e-18

Pssm-ID: 341293 [Multi-domain] Cd Length: 330 Bit Score: 90.25 E-value: 1.01e-18

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  660 IYTSGSTGQPKGVMVRHRALTNFVCSIARQPGMLARDRLLSVTTFsFDIFGLE--LYVPLARGASMLlasREQAQDPEAL 737
Cdd:cd17638      6 MFTSGTTGRSKGVMCAHRQTLRAAAAWADCADLTEDDRYLIINPF-FHTFGYKagIVACLLTGATVV---PVAVFDVDAI 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  738 LDLVERQGVTVLQATPATWRMLCDSERVDLLRGCTL---LCGGEALAEDLAARMRG-LSAST-WNLYGPTETTIwsarfr 812
Cdd:cd17638     82 LEAIERERITVLPGPPTLFQSLLDHPGRKKFDLSSLraaVTGAATVPVELVRRMRSeLGFETvLTAYGLTEAGV------ 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  813 lGEEARPflGGPLENTAlyildsemNPCPPGVAG-ELLIGGDG--LARGYHRRPGltaerFLPDPFA------ADGsrLY 883
Cdd:cd17638    156 -ATMCRP--GDDAETVA--------TTCGRACPGfEVRIADDGevLVRGYNVMQG-----YLDDPEAtaeaidADG--WL 217

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  884 RTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVaqpGVA----GPTLVAYLVPTEAALVDA 959
Cdd:cd17638    218 HTGDVGELDERGYLRITDRLKDMYIVGGFNVYPAEVEGALAEHPGVAQVAVI---GVPdermGEVGKAFVVARPGVTLTE 294

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|...
gi 2183974163  960 ESArqqelrSALKNSLLAvlpDYMVPAHMLLLENLPLTPNGKI 1002
Cdd:cd17638    295 EDV------IAWCRERLA---NYKVPRFVRFLDELPRNASGKV 328

LCL_NRPS

LCL-type Condensation domain of non-ribosomal peptide synthetases (NRPSs) and similar domains; ...

2639-2921

1.50e-18

Pssm-ID: 380461 [Multi-domain] Cd Length: 432 Bit Score: 91.56 E-value: 1.50e-18

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2639 PLSPMQQGMLFHSLYQQNSGDYINQMRLDVEG-LDPQRFREAWQAALDAHEVLRSGFLWQGALekPLQLVR--KRVEVPF 2715
Cdd:cd19538      3 PLSFAQRRLWFLHQLEGPSATYNIPLVIKLKGkLDVQALQQALYDVVERHESLRTVFPEEDGV--PYQLILeeDEATPKL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2716 SVhdwrdRADLAEALDALAAGEAGLGFELAEAPLLRLVLVRTGERRHHLIYTNHHILMDGWSNSQLLGEVLQRYR----G 2791
Cdd:cd19538     81 EI-----KEVDEEELESEINEAVRYPFDLSEEPPFRATLFELGENEHVLLLLLHHIAADGWSLAPLTRDLSKAYRarckG 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2792 ETPSRS--DGRYRDYIAWlQRQDAGRTE----------AFWKQRLQRLGEPTLLV-----PAfahgVRGAEGHADRYrQL 2854
Cdd:cd19538    156 EAPELAplPVQYADYALW-QQELLGDESdpdsliarqlAYWKKQLAGLPDEIELPtdyprPA----ESSYEGGTLTF-EI 229

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2183974163 2855 DVTTSQRLAEFAREQKVTLNTLVQAAWLILLQRFTGQDTVAFGATVSGRPAElrGIEEQIGLFINTL 2921
Cdd:cd19538    230 DSELHQQLLQLAKDNNVTLFMVLQAGFAALLTRLGAGTDIPIGSPVAGRNDD--SLEDLVGFFVNTL 294

PRK13390

acyl-CoA synthetase; Provisional

1576-2066

1.56e-18

acyl-CoA synthetase; Provisional

Pssm-ID: 139538 [Multi-domain] Cd Length: 501 Bit Score: 91.99 E-value: 1.56e-18

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1576 RQAAERPRATAVVYGERaLDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSD 1655
Cdd:PRK13390     8 QIAPDRPAVIVAETGEQ-VSYRQLDDDSAALARVLYDAGLRTGDVVALLSDNSPEALVVLWAALRSGLYITAINHHLTAP 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1656 RLGYMIEDSGIRLLLTQrAARERLPLGEGLPC-LLLDAEHEWAGYPESDPQSAVGVDNL------AYVIYTSGSTGKPKG 1728
Cdd:PRK13390    87 EADYIVGDSGARVLVAS-AALDGLAAKVGADLpLRLSFGGEIDGFGSFEAALAGAGPRLteqpcgAVMLYSSGTTGFPKG 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1729 TL--LPHGNVLRLFDA----TRHWFGFSADDAW----SLFHSYAFDFSvweifgALLH--GGRLVIVpyeTSRSPEDFLR 1796
Cdd:PRK13390   166 IQpdLPGRDVDAPGDPivaiARAFYDISESDIYyssaPIYHAAPLRWC------SMVHalGGTVVLA---KRFDAQATLG 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1797 LLCRERVTVLNQTPSAFKQLMQVAC---AGQEVPplALRHVVFGGEALEV---QALRPWFerfgdrAPRLVNMYGITEtt 1870
Cdd:PRK13390   237 HVERYRITVTQMVPTMFVRLLKLDAdvrTRYDVS--SLRAVIHAAAPCPVdvkHAMIDWL------GPIVYEYYSSTE-- 306

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1871 VH---VTYRPLSLADLDGGAASPIGepipdlSWYLLDAGLNPVPRGCIGELYVGGAGLARGYLNRPELSC-TRFVADPFS 1946
Cdd:PRK13390   307 AHgmtFIDSPDWLAHPGSVGRSVLG------DLHICDDDGNELPAGRIGTVYFERDRLPFRYLNDPEKTAaAQHPAHPFW 380

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1947 TTggrlyrTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVVLPHEGPGATQLVGYVVTQAAPS 2026
Cdd:PRK13390   381 TT------VGDLGSVDEDGYLYLADRKSFMIISGGVNIYPQETENALTMHPAVHDVAVIGVPDPEMGEQVKAVIQLVEGI 454

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|.
gi 2183974163 2027 DPA-ALRDTLRQALKASLPEHMVPAHLLFLERLPLTANGKL 2066
Cdd:PRK13390   455 RGSdELARELIDYTRSRIAHYKAPRSVEFVDELPRTPTGKL 495

caiC

PRK08008

putative crotonobetaine/carnitine-CoA ligase; Validated

509-1007

1.97e-18

putative crotonobetaine/carnitine-CoA ligase; Validated

Pssm-ID: 181195 [Multi-domain] Cd Length: 517 Bit Score: 92.05 E-value: 1.97e-18

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  509 GQGVHRLFEAQAGLTPDAPALLF----GEER-LSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKA 583
Cdd:PRK08008     6 GQHLRQMWDDLADVYGHKTALIFessgGVVRrYSYLELNEEINRTANLFYSLGIRKGDKVALHLDNCPEFIFCWFGLAKI 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  584 GGAYVPLDPQYPADRLQYMIDDSGLRLLLSQQSVL---ARLPQSDG--LQSLLLDDLerlvhGYPAENP------DLPEA 652
Cdd:PRK08008    86 GAIMVPINARLLREESAWILQNSQASLLVTSAQFYpmyRQIQQEDAtpLRHICLTRV-----ALPADDGvssftqLKAQQ 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  653 PDSLCYA-----------IYTSGSTGQPKGVMVRHRALTNFVCSIARQPGMLARDRLLSVTTfSFDI-FGLELYVP-LAR 719
Cdd:PRK08008   161 PATLCYApplstddtaeiLFTSGTTSRPKGVVITHYNLRFAGYYSAWQCALRDDDVYLTVMP-AFHIdCQCTAAMAaFSA 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  720 GASMLLASREQAQdpeALLDLVERQGVTVLQATPATWRML-----CDSERVDLLRGCTL-LCGGEALAEDLAARmrgLSA 793
Cdd:PRK08008   240 GATFVLLEKYSAR---AFWGQVCKYRATITECIPMMIRTLmvqppSANDRQHCLREVMFyLNLSDQEKDAFEER---FGV 313

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  794 STWNLYGPTETTIWSARFRLGEEAR-PFLGGPLENTALYILDSEMNPCPPGVAGELLIG---GDGLARGYHRRPGLTAER 869
Cdd:PRK08008   314 RLLTSYGMTETIVGIIGDRPGDKRRwPSIGRPGFCYEAEIRDDHNRPLPAGEIGEICIKgvpGKTIFKEYYLDPKATAKV 393

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  870 FLPDPFaadgsrLYrTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVaqpGVAGP----TL 945
Cdd:PRK08008   394 LEADGW------LH-TGDTGYVDEEGFFYFVDRRCNMIKRGGENVSCVELENIIATHPKIQDIVVV---GIKDSirdeAI 463

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2183974163  946 VAYLVPTEaalvdAESARQQELRSALKNSLLAvlpdYMVPAHMLLLENLPLTPNGKINRKAL 1007
Cdd:PRK08008   464 KAFVVLNE-----GETLSEEEFFAFCEQNMAK----FKVPSYLEIRKDLPRNCSGKIIKKNL 516

PLN02574

4-coumarate--CoA ligase-like

524-1007

2.21e-18

4-coumarate--CoA ligase-like

Pssm-ID: 215312 [Multi-domain] Cd Length: 560 Bit Score: 91.83 E-value: 2.21e-18

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  524 PDAPALL--FGEERLSYAELNALANRLAWRLREEG--VGSDVlVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRL 599
Cdd:PLN02574    53 NGDTALIdsSTGFSISYSELQPLVKSMAAGLYHVMgvRQGDV-VLLLLPNSVYFPVIFLAVLSLGGIVTTMNPSSSLGEI 131

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  600 QYMIDDSGLRLLLSQQSVLARLPqSDGLQSLLLDD-------------LERLVHGYPAENPDLPEAPDSLCYAIYTSGST 666
Cdd:PLN02574   132 KKRVVDCSVGLAFTSPENVEKLS-PLGVPVIGVPEnydfdskriefpkFYELIKEDFDFVPKPVIKQDDVAAIMYSSGTT 210

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  667 GQPKGVMVRHRaltNFVCSI-------ARQPGMLARDRLLSVTTFSFDIFGLELYVP--LARGASMLLASREQAQDpeaL 737
Cdd:PLN02574   211 GASKGVVLTHR---NLIAMVelfvrfeASQYEYPGSDNVYLAALPMFHIYGLSLFVVglLSLGSTIVVMRRFDASD---M 284

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  738 LDLVERQGVTVLQATPATWRMLCDSER---VDLLRGCTLLCGGEA-----LAEDLAARMRGLSASTWnlYGPTETTIWSA 809
Cdd:PLN02574   285 VKVIDRFKVTHFPVVPPILMALTKKAKgvcGEVLKSLKQVSCGAAplsgkFIQDFVQTLPHVDFIQG--YGMTESTAVGT 362

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  810 RFRLGEEARPF--LGGPLENTALYILDSEMNPC-PPGVAGELLIGGDGLARGYHRRPGLTAERFLPDPFaadgsrlYRTG 886
Cdd:PLN02574   363 RGFNTEKLSKYssVGLLAPNMQAKVVDWSTGCLlPPGNCGELWIQGPGVMKGYLNNPKATQSTIDKDGW-------LRTG 435

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  887 DLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQPGV-AGPTLVAYLVPTEaalvdaESARQQ 965
Cdd:PLN02574   436 DIAYFDEDGYLYIVDRLKEIIKYKGFQIAPADLEAVLISHPEIIDAAVTAVPDKeCGEIPVAFVVRRQ------GSTLSQ 509

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|..
gi 2183974163  966 ElrsALKNSLLAVLPDYMVPAHMLLLENLPLTPNGKINRKAL 1007
Cdd:PLN02574   510 E---AVINYVAKQVAPYKKVRKVVFVQSIPKSPAGKILRREL 548

LC_FACS_bac

cd05932

Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter ...

1596-2058

3.16e-18

Pssm-ID: 341255 [Multi-domain] Cd Length: 508 Bit Score: 90.99 E-value: 3.16e-18

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1596 YGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGYMIEDSGIRLLL----- 1670
Cdd:cd05932      9 WGEVADKARRLAAALRALGLEPGSKIALISKNCAEWFITDLAIWMAGHISVPLYPTLNPDTIRYVLEHSESKALFvgkld 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1671 ----TQRAARERLPLGEGLPCLLLDAEHEW----AGYPESDPQSAVGVDNLAYVIYTSGSTGKPKGTLLPHGNVLRLFDA 1742
Cdd:cd05932     89 dwkaMAPGVPEGLISISLPPPSAANCQYQWddliAQHPPLEERPTRFPEQLATLIYTSGTTGQPKGVMLTFGSFAWAAQA 168

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1743 TRHWFGFSADDAWSLFHSYAFDFSVWEIFGALLHGGRLVIVPYETSRSPEDflrlLCRERVTVLNQTP---SAFKQLMQv 1819
Cdd:cd05932    169 GIEHIGTEENDRMLSYLPLAHVTERVFVEGGSLYGGVLVAFAESLDTFVED----VQRARPTLFFSVPrlwTKFQQGVQ- 243

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1820 acagQEVPP-----------------------LALRHV--VFGGEALEVQALRPWFERFGdraPRLVNMYGITETTV--H 1872
Cdd:cd05932    244 ----DKIPQqklnlllkipvvnslvkrkvlkgLGLDQCrlAGCGSAPVPPALLEWYRSLG---LNILEAYGMTENFAysH 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1873 VTYrPLSlaDLDGgaasPIGEPIPDLSwylldaglnpVPRGCIGELYVGGAGLARGYLNRPELSCTRFVADPFsttggrl 1952
Cdd:cd05932    317 LNY-PGR--DKIG----TVGNAGPGVE----------VRISEDGEILVRSPALMMGYYKDPEATAEAFTADGF------- 372

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1953 YRTGDLARYRCDGVVEYVGRIDHQVKI-RGFRIELGEIEARLLAQPGVAEAVVLpheGPGATQLVGYVVTQAAPSDPAAL 2031
Cdd:cd05932    373 LRTGDKGELDADGNLTITGRVKDIFKTsKGKYVAPAPIENKLAEHDRVEMVCVI---GSGLPAPLALVVLSEEARLRADA 449

                          490       500
                   ....*....|....*....|....*....
gi 2183974163 2032 RDtlRQALKASLPEHM--VPAHLLFLERL 2058
Cdd:cd05932    450 FA--RAELEASLRAHLarVNSTLDSHEQL 476

C_PKS-NRPS

Condensation domain of hybrid polyketide synthetase/nonribosomal peptide synthetases (PKS ...

2205-2495

3.28e-18

Condensation domain of hybrid polyketide synthetase/nonribosomal peptide synthetases (PKS/NRPSs); Condensation (C) domains of nonribosomal peptide synthetases (NRPSs) catalyze peptide bond formation within (usually) large multi-modular enzymatic complexes. Hybrid PKS/NRPS create polymers containing both polyketide and amide linkages. C-domains typically have a conserved HHxxxD motif at the active site; mutations in this motif can abolish or diminish condensation activity. Most members of this subfamily have the typical C-domain HHxxxD motif, a few such as Monascus pilosus lovastatin nonaketide synthase MokA have a non-canonical HRxxxD motif in the C-domain and are unable to catalyze amide-bond formation. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long (with various activities such as antibiotic, antifungal, antitumor and immunosuppression). There are various subtypes of C-domains such as the LCL-type which catalyzes peptide bond formation between two L-amino acids, the DCL-type which links an L-amino acid to the D-amino acid at the end of a growing peptide, starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and heterocyclization (Cyc) domains which catalyze both peptide bond formation and cyclization of Cys, Ser, or Thr residues. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the epimerization (E) domain, the ester-bond forming C-domain, dual E/C (epimerization and condensation) domains, and the X-domain.

Pssm-ID: 380455 [Multi-domain] Cd Length: 421 Bit Score: 90.21 E-value: 3.28e-18

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2205 LDGTL----LETALQALLAHHDALRLGFR------------LEDGTWRAEHRAVEAgevllwqqsvaDGQALEALAEQVQ 2268
Cdd:cd19532     32 LTGPLdvarLERAVRAVGQRHEALRTCFFtdpedgepmqgvLASSPLRLEHVQISD-----------EAEVEEEFERLKN 100

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2269 RSLDLGSGPLLRALLATLGDGSQRLLLVIHHLVVDGVSWRILLEDLQTAYRQLQagqavaLPAKTSAFKAWAERLQAHAR 2348
Cdd:cd19532    101 HVYDLESGETMRIVLLSLSPTEHYLIFGYHHIAMDGVSFQIFLRDLERAYNGQP------LLPPPLQYLDFAARQRQDYE 174

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2349 DGGLEGERGYWLAQLEGVSTELPcddregAQSVRHVRSaRTELTEEATRRLLQEAPAAYRTQVNDL-----------LLT 2417
Cdd:cd19532    175 SGALDEDLAYWKSEFSTLPEPLP------LLPFAKVKS-RPPLTRYDTHTAERRLDAALAARIKEAsrklrvtpfhfYLA 247

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2418 ALARVIGRWTGQADTLIQLEGHGReelfEDIDLTRTVGWFTSLFPLRL--SPVAELGASIKRIKEQLR-AIPHKGLGFGA 2494
Cdd:cd19532    248 ALQVLLARLLDVDDICIGIADANR----TDEDFMETIGFFLNLLPLRFrrDPSQTFADVLKETRDKAYaALAHSRVPFDV 323


                   .
gi 2183974163 2495 L 2495
Cdd:cd19532    324 L 324

PRK12476

putative fatty-acid--CoA ligase; Provisional

1566-2070

3.41e-18

putative fatty-acid--CoA ligase; Provisional

Pssm-ID: 171527 [Multi-domain] Cd Length: 612 Bit Score: 91.73 E-value: 3.41e-18

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1566 PASCLHRLIERQAAERprATAVVYgeRALDYGE------LNLRANRLAHRLIELG------VGPDVLVGLAAERSLEMIV 1633
Cdd:PRK12476    32 PGTTLISLIERNIANV--GDTVAY--RYLDHSHsaagcaVELTWTQLGVRLRAVGarlqqvAGPGDRVAILAPQGIDYVA 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1634 GLLAILKAGGAYVPL-DPRYP--SDRLGYMIEDSGIRLLLTQRAARE-------RLPLGEGLPCLLLDAEHEWAGypESD 1703
Cdd:PRK12476   108 GFFAAIKAGTIAVPLfAPELPghAERLDTALRDAEPTVVLTTTAAAEavegflrNLPRLRRPRVIAIDAIPDSAG--ESF 185

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1704 PQSAVGVDNLAYVIYTSGSTGKPKGTLLPHGNV----------LRLFDATRHwfGFSaddaW-SLFHsyafDFSVWEIFG 1772
Cdd:PRK12476   186 VPVELDTDDVSHLQYTSGSTRPPVGVEITHRAVgtnlvqmilsIDLLDRNTH--GVS----WlPLYH----DMGLSMIGF 255

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1773 ALLHGGRLVIV-PYETSRSPEDFLRLL---CRERVTVLNQTPSAFKqlmqvACAGQEVPP----LALRHVVF--GGEALE 1842
Cdd:PRK12476   256 PAVYGGHSTLMsPTAFVRRPQRWIKALsegSRTGRVVTAAPNFAYE-----WAAQRGLPAegddIDLSNVVLiiGSEPVS 330

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1843 VQALRPW---FERFGDRAPRLVNMYGITETTVHV-TYRP--------LSLADLDGGAASPI-------------GEPIPD 1897
Cdd:PRK12476   331 IDAVTTFnkaFAPYGLPRTAFKPSYGIAEATLFVaTIAPdaepsvvyLDREQLGAGRAVRVaadapnavahvscGQVARS 410

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1898 LSWYLLDAGL-NPVPRGCIGELYVGGAGLARGYLNRPELSCTRFVADPFSTT-----------GGRLYRTGDLARYRcDG 1965
Cdd:PRK12476   411 QWAVIVDPDTgAELPDGEVGEIWLHGDNIGRGYWGRPEETERTFGAKLQSRLaegshadgaadDGTWLRTGDLGVYL-DG 489

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1966 VVEYVGRIDHQVKIRGFR-----IELGEIEARLLAQPGVAEAVVLPHEGPGATQLVGYVVTQAAPSDPAALRDTLRQALK 2040
Cdd:PRK12476   490 ELYITGRIADLIVIDGRNhypqdIEATVAEASPMVRRGYVTAFTVPAEDNERLVIVAERAAGTSRADPAPAIDAIRAAVS 569

                          570       580       590
                   ....*....|....*....|....*....|...
gi 2183974163 2041 AslpEHMVP-AHLLFLER--LPLTANGKLDRRA 2070
Cdd:PRK12476   570 R---RHGLAvADVRLVPAgaIPRTTSGKLARRA 599

PRK13388

acyl-CoA synthetase; Provisional

525-1007

4.72e-18

acyl-CoA synthetase; Provisional

Pssm-ID: 237374 [Multi-domain] Cd Length: 540 Bit Score: 90.86 E-value: 4.72e-18

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  525 DAPALLFGEERLSYAELNALANRLAWRLREEGVGSDVL-VGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQYMI 603
Cdd:PRK13388    16 DTIAVRYGDRTWTWREVLAEAAARAAALIALADPDRPLhVGVLLGNTPEMLFWLAAAALGGYVLVGLNTTRRGAALAADI 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  604 DDSGLRLLLSQQsvlARLPQSDGL-----QSLLLDDLE--RLVHGYPAENPDLPEAPDSLCYAIYTSGSTGQPKGVMVRH 676
Cdd:PRK13388    96 RRADCQLLVTDA---EHRPLLDGLdlpgvRVLDVDTPAyaELVAAAGALTPHREVDAMDPFMLIFTSGTTGAPKAVRCSH 172

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  677 RALTNFVCSIARQPGMLARDrllsVTTFSFDIFG----LELYVP-LARGASMLLASREQAQdpeALLDLVERQGVT---- 747
Cdd:PRK13388   173 GRLAFAGRALTERFGLTRDD----VCYVSMPLFHsnavMAGWAPaVASGAAVALPAKFSAS---GFLDDVRRYGATyfny 245

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  748 ------VLQATPatwrmlcdsERVD-----LLRGctllCGGEALAEDLAARMRGLSASTWNLYGPTETTIWSARfrlgEE 816
Cdd:PRK13388   246 vgkplaYILATP---------ERPDdadnpLRVA----FGNEASPRDIAEFSRRFGCQVEDGYGSSEGAVIVVR----EP 308

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  817 ARP--FLGGPLENTALYILDSeMNPCPPGV---AGELL-----IG------GDGLARGYHRRPGLTAERFlpdpfaADGs 880
Cdd:PRK13388   309 GTPpgSIGRGAPGVAIYNPET-LTECAVARfdaHGALLnadeaIGelvntaGAGFFEGYYNNPEATAERM------RHG- 380

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  881 rLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQP-GVAGPTLVAYLVPTEAALVD- 958
Cdd:PRK13388   381 -MYWSGDLAYRDADGWIYFAGRTADWMRVDGENLSAAPIERILLRHPAINRVAVYAVPdERVGDQVMAALVLRDGATFDp 459

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2183974163  959 AESARqqelrsalknsLLAVLPDY---MVPAHMLLLENLPLTPNGKINRKAL 1007
Cdd:PRK13388   460 DAFAA-----------FLAAQPDLgtkAWPRYVRIAADLPSTATNKVLKREL 500

PLN02246

4-coumarate--CoA ligase

1570-2020

6.58e-18

4-coumarate--CoA ligase

Pssm-ID: 215137 [Multi-domain] Cd Length: 537 Bit Score: 90.42 E-value: 6.58e-18

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1570 LHRLIERQAAERPRATAVVYGE--RALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVP 1647
Cdd:PLN02246    25 LHDYCFERLSEFSDRPCLIDGAtgRVYTYADVELLSRRVAAGLHKLGIRQGDVVMLLLPNCPEFVLAFLGASRRGAVTTT 104

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1648 LDPRYPSDRLGYMIEDSGIRLLLTQRAARERLP---LGEGLPCLLLDAEHE----WAGYPESD----PQSAVGVDNLAYV 1716
Cdd:PLN02246   105 ANPFYTPAEIAKQAKASGAKLIITQSCYVDKLKglaEDDGVTVVTIDDPPEgclhFSELTQADenelPEVEISPDDVVAL 184

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1717 IYTSGSTGKPKGTLLPHGN----VLRLFDATRHWFGFSADDA----WSLFHSYAFDfSVweIFGALLHGGRLVIVP-YET 1787
Cdd:PLN02246   185 PYSSGTTGLPKGVMLTHKGlvtsVAQQVDGENPNLYFHSDDVilcvLPMFHIYSLN-SV--LLCGLRVGAAILIMPkFEI 261

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1788 SRspedFLRLLCRERVTVlnqtpSAFkqlmqvacagqeVPPLAL----------------RHVVFG----GEALEvqalr 1847
Cdd:PLN02246   262 GA----LLELIQRHKVTI-----APF------------VPPIVLaiakspvvekydlssiRMVLSGaaplGKELE----- 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1848 pwfERFGDRAPRLV--NMYGITET-----------------------TVhVTYRPLSLADLDGGAASPIGEPipdlswyl 1902
Cdd:PLN02246   316 ---DAFRAKLPNAVlgQGYGMTEAgpvlamclafakepfpvksgscgTV-VRNAELKIVDPETGASLPRNQP-------- 383

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1903 ldaglnpvprgciGELYVGGAGLARGYLNRPElsCTRFVADpfstTGGRLYrTGDLARYRCDGVVEYVGRIDHQVKIRGF 1982
Cdd:PLN02246   384 -------------GEICIRGPQIMKGYLNDPE--ATANTID----KDGWLH-TGDIGYIDDDDELFIVDRLKELIKYKGF 443

                          490       500       510
                   ....*....|....*....|....*....|....*....
gi 2183974163 1983 RIELGEIEARLLAQPGVAEAVVLPHEGPGATQL-VGYVV 2020
Cdd:PLN02246   444 QVAPAELEALLISHPSIADAAVVPMKDEVAGEVpVAFVV 482

PRK00174

acetyl-CoA synthetase; Provisional

1715-2071

8.66e-18

acetyl-CoA synthetase; Provisional

Pssm-ID: 234677 [Multi-domain] Cd Length: 637 Bit Score: 90.59 E-value: 8.66e-18

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1715 YVIYTSGSTGKPKGTLLPHGNVLrLFDATRHWFGF----------SADDAWSLFHSYAfdfsvweIFGALLHGGRLVIvp 1784
Cdd:PRK00174   249 FILYTSGSTGKPKGVLHTTGGYL-VYAAMTMKYVFdykdgdvywcTADVGWVTGHSYI-------VYGPLANGATTLM-- 318

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1785 YE---TSRSPEDFLRLLCRERVTVLNQTPSAFKQLMQvacAGQEVP------PLALRHVVfgGEALEVQALRpWFERF-- 1853
Cdd:PRK00174   319 FEgvpNYPDPGRFWEVIDKHKVTIFYTAPTAIRALMK---EGDEHPkkydlsSLRLLGSV--GEPINPEAWE-WYYKVvg 392

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1854 GDRAPrLVNMYGITETTVHVTyRPL-SLADLDGGAASPigePIPDLSWYLLDAGLNPVPRGCIGELYVGGA--GLARGYL 1930
Cdd:PRK00174   393 GERCP-IVDTWWQTETGGIMI-TPLpGATPLKPGSATR---PLPGIQPAVVDEEGNPLEGGEGGNLVIKDPwpGMMRTIY 467

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1931 NRPElsctRFVADPFSTTGGRlYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVVL--PHE 2008
Cdd:PRK00174   468 GDHE----RFVKTYFSTFKGM-YFTGDGARRDEDGYYWITGRVDDVLNVSGHRLGTAEIESALVAHPKVAEAAVVgrPDD 542

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2183974163 2009 --GPGatqLVGYVVTQAAPSDPAALRDTLRQALKASLPEHMVPAHLLFLERLPLTANGKLDRRAL 2071
Cdd:PRK00174   543 ikGQG---IYAFVTLKGGEEPSDELRKELRNWVRKEIGPIAKPDVIQFAPGLPKTRSGKIMRRIL 604

C_PKS-NRPS_PksJ-like

Condensation domain of hybrid polyketide synthetase/nonribosomal peptide synthetases (PKS ...

2203-2464

9.27e-18

Pssm-ID: 380472 [Multi-domain] Cd Length: 430 Bit Score: 88.91 E-value: 9.27e-18

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2203 QALDGTLLETALQALLAHHDALRLGFRLEDGTwraEHRAVEAGEVLLWQQ----SVADGQALEALAEQVQRSLDLGSGPL 2278
Cdd:cd20484     34 SKLDVEKFKQACQFVLEQHPILKSVIEEEDGV---PFQKIEPSKPLSFQEedisSLKESEIIAYLREKAKEPFVLENGPL 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2279 LRALLATLGDGSQRLLLVIHHLVVDGVSWRILLEDLQTAYRQLQAGQAVAL---PAKTSAFKAWAERLQAhardgGLEGE 2355
Cdd:cd20484    111 MRVHLFSRSEQEHFVLITIHHIIFDGSSSLTLIHSLLDAYQALLQGKQPTLassPASYYDFVAWEQDMLA-----GAEGE 185

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2356 --RGYWLAQLEGV--STELPCDdregaqsvrHVRSARTELTEEATRRLLQEA--------PAAYRTQVNDLLLTALARVI 2423
Cdd:cd20484    186 ehRAYWKQQLSGTlpILELPAD---------RPRSSAPSFEGQTYTRRLPSElsnqiksfARSQSINLSTVFLGIFKLLL 256

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|..
gi 2183974163 2424 GRWTGQADTLIQLEGHGR-EELFEDIdltrtVGWFTSLFPLR 2464
Cdd:cd20484    257 HRYTGQEDIIVGMPTMGRpEERFDSL-----IGYFINMLPIR 293

PRK07798

acyl-CoA synthetase; Validated

3090-3183

1.08e-17

acyl-CoA synthetase; Validated

Pssm-ID: 236100 [Multi-domain] Cd Length: 533 Bit Score: 89.56 E-value: 1.08e-17

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3090 LFEEQVERTPTAPALAFGEERLDYAELNRRANRLAHALIERGIGADRLVGVAMERSIEMVVALMAILKAGGAYVPVDPEY 3169
Cdd:PRK07798     8 LFEAVADAVPDRVALVCGDRRLTYAELEERANRLAHYLIAQGLGPGDHVGIYARNRIEYVEAMLGAFKARAVPVNVNYRY 87

                           90
                   ....*....|....
gi 2183974163 3170 PEERQAYMLEDSGV 3183
Cdd:PRK07798    88 VEDELRYLLDDSDA 101

FATP_chFAT1_like

cd05937

Uncharacterized subfamily of bifunctional fatty acid transporter/very-long-chain acyl-CoA ...

1589-2065

1.16e-17

Uncharacterized subfamily of bifunctional fatty acid transporter/very-long-chain acyl-CoA synthetase in fungi; Fatty acid transport protein (FATP) transports long-chain or very-long-chain fatty acids across the plasma membrane. FATPs also have fatty acid CoA synthetase activity, thus playing dual roles as fatty acid transporters and its activation enzymes. FATPs are the key players in the trafficking of exogenous fatty acids into the cell and in intracellular fatty acid homeostasis. Members of this family are fungal FATPs, including FAT1 from Cochliobolus heterostrophus.

Pssm-ID: 341260 [Multi-domain] Cd Length: 468 Bit Score: 89.03 E-value: 1.16e-17

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1589 YGERALDYGELNLRANRLAHRLI-ELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGYMIEDSGIR 1667
Cdd:cd05937      1 FEGKTWTYSETYDLVLRYAHWLHdDLGVQAGDFVAIDLTNSPEFVFLWLGLWSIGAAPAFINYNLSGDPLIHCLKLSGSR 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1668 LLLtqraarerlplgeglpcllldaehewagypeSDPqsavgvDNLAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRHWF 1747
Cdd:cd05937     81 FVI-------------------------------VDP------DDPAILIYTSGTTGLPKAAAISWRRTLVTSNLLSHDL 123

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1748 GFSADDAW----SLFHSYAFdfsvweIFGA---LLHGGRLVIVP-----------YETSRSPEDFLRLLCRervTVLNQT 1809
Cdd:cd05937    124 NLKNGDRTytcmPLYHGTAA------FLGAcncLMSGGTLALSRkfsasqfwkdvRDSGATIIQYVGELCR---YLLSTP 194

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1810 PSAFKQLMQVACAgqevpplalrhvvFGgealevQALRP--WfERFGDR--APRLVNMYGITETtvhvtyrPLSLADLDG 1885
Cdd:cd05937    195 PSPYDRDHKVRVA-------------WG------NGLRPdiW-ERFRERfnVPEIGEFYAATEG-------VFALTNHNV 247

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1886 GA--ASPIGEPIPDLSWYLLDaGLNPV---------------------PRGCIGELYV----GGAGLARGYLNRPELSCT 1938
Cdd:cd05937    248 GDfgAGAIGHHGLIRRWKFEN-QVVLVkmdpetddpirdpktgfcvraPVGEPGEMLGrvpfKNREAFQGYLHNEDATES 326

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1939 RFVADPFSTtGGRLYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVVLPHEGPGATQLVGY 2018
Cdd:cd05937    327 KLVRDVFRK-GDIYFRTGDLLRQDADGRWYFLDRLGDTFRWKSENVSTTEVADVLGAHPDIAEANVYGVKVPGHDGRAGC 405

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2183974163 2019 VVTQAAPSdpAALRDTLRQALKAS-----LPEHMVPAHLLFLERLPLTANGK 2065
Cdd:cd05937    406 AAITLEES--SAVPTEFTKSLLASlarknLPSYAVPLFLRLTEEVATTDNHK 455

PRK08315

AMP-binding domain protein; Validated

1572-2065

1.58e-17

AMP-binding domain protein; Validated

Pssm-ID: 236236 [Multi-domain] Cd Length: 559 Bit Score: 89.10 E-value: 1.58e-17

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1572 RLIERQAAERPRATAVVYGERAL--DYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLD 1649
Cdd:PRK08315    20 QLLDRTAARYPDREALVYRDQGLrwTYREFNEEVDALAKGLLALGIEKGDRVGIWAPNVPEWVLTQFATAKIGAILVTIN 99

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1650 PRYPSDRLGYMIEDSGIRLLLTQRAAR------------------ERLPL-GEGLPCL----LLDAEHEWAGYPESD-PQ 1705
Cdd:PRK08315   100 PAYRLSELEYALNQSGCKALIAADGFKdsdyvamlyelapelatcEPGQLqSARLPELrrviFLGDEKHPGMLNFDElLA 179

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1706 SAVGVDNLAY-----------VI---YTSGSTGKPKGTLLPHGNVLR--LFDATRhwFGFSADDAW----SLFHSYAfdf 1765
Cdd:PRK08315   180 LGRAVDDAELaarqatldpddPIniqYTSGTTGFPKGATLTHRNILNngYFIGEA--MKLTEEDRLcipvPLYHCFG--- 254

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1766 SVWEIFGALLHGGRLVIvPYEtSRSPEDFLRLLCRERVTVLNQTPSAFkqlmqvaCAGQEVPPLA------LRHVVFGGE 1839
Cdd:PRK08315   255 MVLGNLACVTHGATMVY-PGE-GFDPLATLAAVEEERCTALYGVPTMF-------IAELDHPDFArfdlssLRTGIMAGS 325

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1840 ALEVQALRpwferfgdRAPRLVNM------YGITETTvhvtyrPLSLADldgGAASPI-------GEPIPDLSWYLLDAG 1906
Cdd:PRK08315   326 PCPIEVMK--------RVIDKMHMsevtiaYGMTETS------PVSTQT---RTDDPLekrvttvGRALPHLEVKIVDPE 388

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1907 LN-PVPRGCIGELYVGGAGLARGYLNRPELscTRFVADPfsttGGRLyRTGDLARYRCDGVVEYVGRIDHQVkIRGfrie 1985
Cdd:PRK08315   389 TGeTVPRGEQGELCTRGYSVMKGYWNDPEK--TAEAIDA----DGWM-HTGDLAVMDEEGYVNIVGRIKDMI-IRG---- 456

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1986 lG------EIEARLLAQPGVAEAVV--LPHEGPGaTQLVGYVVTQA-APSDPAALRDTLRqalkASLPEHMVPAHLLFLE 2056
Cdd:PRK08315   457 -GeniyprEIEEFLYTHPKIQDVQVvgVPDEKYG-EEVCAWIILRPgATLTEEDVRDFCR----GKIAHYKIPRYIRFVD 530


                   ....*....
gi 2183974163 2057 RLPLTANGK 2065
Cdd:PRK08315   531 EFPMTVTGK 539

FADD10

cd17635

adenylate forming domain, fatty acid CoA ligase (FadD10); This family contains long chain ...

660-1004

2.26e-17

Pssm-ID: 341290 [Multi-domain] Cd Length: 340 Bit Score: 86.55 E-value: 2.26e-17

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  660 IYTSGSTGQPKGVMVRHR-ALTNFVCSIARQPGMLARDRLLSVTTFSFDIFGLELYVPL-ARGASMLLASREQAQdpeAL 737
Cdd:cd17635      7 IFTSGTTGEPKAVLLANKtFFAVPDILQKEGLNWVVGDVTYLPLPATHIGGLWWILTCLiHGGLCVTGGENTTYK---SL 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  738 LDLVERQGVTVLQATPATWRMLCdSERVDLLRGCTLL----CGGE-ALAEDLAARMRGLSASTWNLYGPTETT-IWSARF 811
Cdd:cd17635     84 FKILTTNAVTTTCLVPTLLSKLV-SELKSANATVPSLrligYGGSrAIAADVRFIEATGLTNTAQVYGLSETGtALCLPT 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  812 RLGEEARPFLGGPLENTALYILDSEMNPCPPGVAGELLIGGDGLARGYHRRPGLTAERFLPDPFaadgsrlyRTGDLARY 891
Cdd:cd17635    163 DDDSIEINAVGRPYPGVDVYLAATDGIAGPSASFGTIWIKSPANMLGYWNNPERTAEVLIDGWV--------NTGDLGER 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  892 RADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQP-GVAGPTLVAYLVPTEaalVDAESArqqelRSA 970
Cdd:cd17635    235 REDGFLFITGRSSESINCGGVKIAPDEVERIAEGVSGVQECACYEISdEEFGELVGLAVVASA---ELDENA-----IRA 306

                          330       340       350
                   ....*....|....*....|....*....|....
gi 2183974163  971 LKNSLLAVLPDYMVPAHMLLLENLPLTPNGKINR 1004
Cdd:cd17635    307 LKHTIRRELEPYARPSTIVIVTDIPRTQSGKVKR 340

PRK09192

fatty acyl-AMP ligase;

1591-2068

2.59e-17

fatty acyl-AMP ligase;

Pssm-ID: 236403 [Multi-domain] Cd Length: 579 Bit Score: 88.52 E-value: 2.59e-17

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1591 ERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYP-------SDRLGYMIED 1663
Cdd:PRK09192    47 EEALPYQTLRARAEAGARRLLALGLKPGDRVALIAETDGDFVEAFFACQYAGLVPVPLPLPMGfggresyIAQLRGMLAS 126

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1664 SGIRLLLTQR-------AARERLPLGEGLPCLLLDAEHEWAG-YPESDPqsavgvDNLAYVIYTSGSTGKPKGTLLPHGN 1735
Cdd:PRK09192   127 AQPAAIITPDellpwvnEATHGNPLLHVLSHAWFKALPEADVaLPRPTP------DDIAYLQYSSGSTRFPRGVIITHRA 200

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1736 VL-RLFDATRHWFGFSADD---AW-SLFHsyafDFSVWEIFGALLHGGrlVIVPY----ETSRSPEDFLRLLCRERVTVl 1806
Cdd:PRK09192   201 LMaNLRAISHDGLKVRPGDrcvSWlPFYH----DMGLVGFLLTPVATQ--LSVDYlptrDFARRPLQWLDLISRNRGTI- 273

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1807 NQTPSAFKQLMQVACAGQEVPPLAL---RHVVFGGEALEVQALRPWFERFGD---RAPRLVNMYGITETTVHVTYRPLS- 1879
Cdd:PRK09192   274 SYSPPFGYELCARRVNSKDLAELDLscwRVAGIGADMIRPDVLHQFAEAFAPagfDDKAFMPSYGLAEATLAVSFSPLGs 353

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1880 -----LADLD----GGAASPI-------------GEPIPDLSWYLLDAGLNPVPRGCIGELYVGGAGLARGYLNRPElsc 1937
Cdd:PRK09192   354 givveEVDRDrleyQGKAVAPgaetrrvrtfvncGKALPGHEIEIRNEAGMPLPERVVGHICVRGPSLMSGYFRDEE--- 430

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1938 trfVADPFSTTGgrLYRTGDLArYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGV--AEAVVLPHEGPGATQL 2015
Cdd:PRK09192   431 ---SQDVLAADG--WLDTGDLG-YLLDGYLYITGRAKDLIIINGRNIWPQDIEWIAEQEPELrsGDAAAFSIAQENGEKI 504

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2183974163 2016 VgyVVTQAAPSDP---AALRDTLRQALKAslpEH-------MVPAHllfleRLPLTANGKLDR 2068
Cdd:PRK09192   505 V--LLVQCRISDEerrGQLIHALAALVRS---EFgveaaveLVPPH-----SLPRTSSGKLSR 557

PRK06018

putative acyl-CoA synthetase; Provisional

1562-2086

2.98e-17

putative acyl-CoA synthetase; Provisional

Pssm-ID: 235673 [Multi-domain] Cd Length: 542 Bit Score: 88.27 E-value: 2.98e-17

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1562 QDFtPASClHRLIE---RQAAERPRATAVVYGE--RAlDYGELNLRANRLAHRLIELGVGP-DVLVGLA--AERSLEMIV 1633
Cdd:PRK06018     6 QDW-PLLC-HRIIDhaaRIHGNREVVTRSVEGPivRT-TYAQIHDRALKVSQALDRDGIKLgDRVATIAwnTWRHLEAWY 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1634 GLLAIlkaGGAYVPLDPRYPSDRLGYMIEDSGIRLLLTQ-------RAARERLPLGEGLpCLLLDAEH------------ 1694
Cdd:PRK06018    83 GIMGI---GAICHTVNPRLFPEQIAWIINHAEDRVVITDltfvpilEKIADKLPSVERY-VVLTDAAHmpqttlknavay 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1695 -----------EWAGYPEsdpqsavgvDNLAYVIYTSGSTGKPKGTLLPH-GNVLR-LFDATRHWFGFSADDAW----SL 1757
Cdd:PRK06018   159 eewiaeadgdfAWKTFDE---------NTAAGMCYTSGTTGDPKGVLYSHrSNVLHaLMANNGDALGTSAADTMlpvvPL 229

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1758 FHSYAfdfsvWEI-FGALLHGGRLVIvP---------YEtsrspedflrLLCRERVTVLNQTPSAFKQLMQ-VACAGQEV 1826
Cdd:PRK06018   230 FHANS-----WGIaFSAPSMGTKLVM-PgakldgasvYE----------LLDTEKVTFTAGVPTVWLMLLQyMEKEGLKL 293

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1827 PplALRHVVFGGEALEvqalRPWFERFGDRAPRLVNMYGITETTVHVTYRPLS--LADLDGGAASPI----GEPIPDLSW 1900
Cdd:PRK06018   294 P--HLKMVVCGGSAMP----RSMIKAFEDMGVEVRHAWGMTEMSPLGTLAALKppFSKLPGDARLDVlqkqGYPPFGVEM 367

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1901 YLLDAGLNPVPRG--CIGELYVGGAGLARGYLnrpelsctRFVADPFSTTGgrLYRTGDLARYRCDGVVEYVGRIDHQVK 1978
Cdd:PRK06018   368 KITDDAGKELPWDgkTFGRLKVRGPAVAAAYY--------RVDGEILDDDG--FFDTGDVATIDAYGYMRITDRSKDVIK 437

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1979 IRGFRIELGEIEARLLAQPGVAEAVV--LPHEGPGATQLvgyVVTQAAPSDPAAlRDTLRQALKASLPEHMVPAHLLFLE 2056
Cdd:PRK06018   438 SGGEWISSIDLENLAVGHPKVAEAAVigVYHPKWDERPL---LIVQLKPGETAT-REEILKYMDGKIAKWWMPDDVAFVD 513

                          570       580       590
                   ....*....|....*....|....*....|.
gi 2183974163 2057 RLPLTANGKLDRRALpapdasRLQ-RDYTAP 2086
Cdd:PRK06018   514 AIPHTATGKILKTAL------REQfKDYKLP 538

DltA

cd05945

D-alanine:D-alanyl carrier protein ligase (DltA) and similar proteins; This family includes ...

3095-3182

3.09e-17

Pssm-ID: 341267 [Multi-domain] Cd Length: 449 Bit Score: 87.69 E-value: 3.09e-17

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3095 VERTPTAPALAFGEERLDYAELNRRANRLAHALIERGIGADRLVGVAMERSIEMVVALMAILKAGGAYVPVDPEYPEERQ 3174
Cdd:cd05945      1 AAANPDRPAVVEGGRTLTYRELKERADALAAALASLGLDAGDPVVVYGHKSPDAIAAFLAALKAGHAYVPLDASSPAERI 80


                   ....*...
gi 2183974163 3175 AYMLEDSG 3182
Cdd:cd05945     81 REILDAAK 88

FACL_like_4

cd05944

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ...

653-1007

3.13e-17

Pssm-ID: 341266 [Multi-domain] Cd Length: 359 Bit Score: 86.38 E-value: 3.13e-17

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  653 PDSLCYAIYTSGSTGQPKgvMVRHRaltnfVCSIARQPGMLARDRLLSVTTFS------FDIFGL--ELYVPLARGASML 724
Cdd:cd05944      1 SDDVAAYFHTGGTTGTPK--LAQHT-----HSNEVYNAWMLALNSLFDPDDVLlcglplFHVNGSvvTLLTPLASGAHVV 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  725 LASREQAQDPEALLD---LVERQGVTVLQATPATWRMLC---DSERVDLLRGCtlLCGGEALAEDLAARMR-GLSASTWN 797
Cdd:cd05944     74 LAGPAGYRNPGLFDNfwkLVERYRITSLSTVPTVYAALLqvpVNADISSLRFA--MSGAAPLPVELRARFEdATGLPVVE 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  798 LYGPTETTIWSARFRLGEEARPFLGG---PLENTALYILDSEMN---PCPPGVAGELLIGGDGLARGYhrrpgLTAERFL 871
Cdd:cd05944    152 GYGLTEATCLVAVNPPDGPKRPGSVGlrlPYARVRIKVLDGVGRllrDCAPDEVGEICVAGPGVFGGY-----LYTEGNK 226

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  872 pDPFAADGsrLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQPGV-AGPTLVAY-- 948
Cdd:cd05944    227 -NAFVADG--WLNTGDLGRLDADGYLFITGRAKDLIIRGGHNIDPALIEEALLRHPAVAFAGAVGQPDAhAGELPVAYvq 303

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2183974163  949 LVP----TEAALVDAESARQQElRSAlknsllavlpdymVPAHMLLLENLPLTPNGKINRKAL 1007
Cdd:cd05944    304 LKPgavvEEEELLAWARDHVPE-RAA-------------VPKHIEVLEELPVTAVGKVFKPAL 352

PRK09274

peptide synthase; Provisional

1572-2071

3.22e-17

peptide synthase; Provisional

Pssm-ID: 236443 [Multi-domain] Cd Length: 552 Bit Score: 88.42 E-value: 3.22e-17

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1572 RLIERQAAERPRATAVVYGE----------RALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKA 1641
Cdd:PRK09274    10 RHLPRAAQERPDQLAVAVPGgrgadgklayDELSFAELDARSDAIAHGLNAAGIGRGMRAVLMVTPSLEFFALTFALFKA 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1642 GGAYVPLDPRYPSDRLGYMIEDS------GI------RLLL--TQRAARERLPLGEGL----PCLL-LDAEHEWAGYPES 1702
Cdd:PRK09274    90 GAVPVLVDPGMGIKNLKQCLAEAqpdafiGIpkahlaRRLFgwGKPSVRRLVTVGGRLlwggTTLAtLLRDGAAAPFPMA 169

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1703 DPQSavgvDNLAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRHWFGFSADDawslfhsyaFD---FSVWEIFGALLhGGR 1779
Cdd:PRK09274   170 DLAP----DDMAAILFTSGSTGTPKGVVYTHGMFEAQIEALREDYGIEPGE---------IDlptFPLFALFGPAL-GMT 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1780 LVIVPYETSR----SPEDFLRLLCRERVTVLNQTPSAFKQLMQVACAGQEVPPlALRHVVFGGEALEVQALrpwfERFGD 1855
Cdd:PRK09274   236 SVIPDMDPTRpatvDPAKLFAAIERYGVTNLFGSPALLERLGRYGEANGIKLP-SLRRVISAGAPVPIAVI----ERFRA 310

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1856 RAP---RLVNMYGITE--------------TTVHVTyrplsladlDGGAASPIGEPIPDLSWYLLDAGLNP--------- 1909
Cdd:PRK09274   311 MLPpdaEILTPYGATEalpissiesreilfATRAAT---------DNGAGICVGRPVDGVEVRIIAISDAPipewddalr 381

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1910 VPRGCIGELYVGGAGLARGYLNRPElsCTRF--VADPfstTGGRLYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELG 1987
Cdd:PRK09274   382 LATGEIGEIVVAGPMVTRSYYNRPE--ATRLakIPDG---QGDVWHRMGDLGYLDAQGRLWFCGRKAHRVETAGGTLYTI 456

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1988 EIEARLLAQPGVAEAVVLPHEGPGATQLVgyVVTQAAPSDpAALRDTLRQALKASLPEHMVPA---HLLFLERLPLTA-- 2062
Cdd:PRK09274   457 PCERIFNTHPGVKRSALVGVGVPGAQRPV--LCVELEPGV-ACSKSALYQELRALAAAHPHTAgieRFLIHPSFPVDIrh 533


                   ....*....
gi 2183974163 2063 NGKLDRRAL 2071
Cdd:PRK09274   534 NAKIFREKL 542

starter-C_NRPS

Starter Condensation domains, found in the first module of nonribosomal peptide synthetases ...

2188-2485

3.90e-17

Pssm-ID: 380456 [Multi-domain] Cd Length: 419 Bit Score: 87.04 E-value: 3.90e-17

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2188 PRRQHWNQSVLLEPGQALDGTLLETALQALLAHHDALRLGFRLEDGT---WRAEHRAVEAGEVLLWQQSVADGQALEALA 2264
Cdd:cd19533     19 PEGSIYNLAEYLEITGPVDLAVLERALRQVIAEAETLRLRFTEEEGEpyqWIDPYTPVPIRHIDLSGDPDPEGAAQQWMQ 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2265 EQVQRSLDLGSGPLLRALLATLGDGSQRLLLVIHHLVVDGVSWRILLEDLQTAYRQLQAGQAVALPAKTSAFKAWAERlQ 2344
Cdd:cd19533     99 EDLRKPLPLDNDPLFRHALFTLGDNRHFWYQRVHHIVMDGFSFALFGQRVAEIYTALLKGRPAPPAPFGSFLDLVEEE-Q 177

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2345 AHARDGGLEGERGYWLAQLEGVSTELPCDDREGAQSVRHVRsaRT-ELTEEATRRLLqEAPAAYRTQVNDLLLTALARVI 2423
Cdd:cd19533    178 AYRQSERFERDRAFWTEQFEDLPEPVSLARRAPGRSLAFLR--RTaELPPELTRTLL-EAAEAHGASWPSFFIALVAAYL 254

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2183974163 2424 GRWTGQADTLIQLEGHGReelfEDIDLTRTVGWFTSLFPLRLS-----PVAELgasIKRIKEQLRAI 2485
Cdd:cd19533    255 HRLTGANDVVLGVPVMGR----LGAAARQTPGMVANTLPLRLTvdpqqTFAEL---VAQVSRELRSL 314

PRK07824

o-succinylbenzoate--CoA ligase;

1711-2071

4.28e-17

o-succinylbenzoate--CoA ligase;

Pssm-ID: 236108 [Multi-domain] Cd Length: 358 Bit Score: 85.87 E-value: 4.28e-17

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1711 DNLAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRHWFGFSAddAWSL----FHSYAFDFSVweifGALLHGGRLVIVPYE 1786
Cdd:PRK07824    35 DDVALVVATSGTTGTPKGAMLTAAALTASADATHDRLGGPG--QWLLalpaHHIAGLQVLV----RSVIAGSEPVELDVS 108

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1787 TSRSPEDFLRLLCR----ERVTVLNQTpsafkQLMQVACAGQEVPPLA-LRHVVFGGEALEvqalRPWFERFGDRAPRLV 1861
Cdd:PRK07824   109 AGFDPTALPRAVAElgggRRYTSLVPM-----QLAKALDDPAATAALAeLDAVLVGGGPAP----APVLDAAAAAGINVV 179

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1862 NMYGITETTVHVTY--RPLSladldgGAASPIGEpipdlswylldaglnpvprgciGELYVGGAGLARGYLNRPElsctr 1939
Cdd:PRK07824   180 RTYGMSETSGGCVYdgVPLD------GVRVRVED----------------------GRIALGGPTLAKGYRNPVD----- 226

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1940 fvADPFSTTGgrLYRTGDLARYRcDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVV--LPHEGPGaTQLVG 2017
Cdd:PRK07824   227 --PDPFAEPG--WFRTDDLGALD-DGVLTVLGRADDAISTGGLTVLPQVVEAALATHPAVADCAVfgLPDDRLG-QRVVA 300

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2183974163 2018 YVVTQAAPSDPAalrDTLRQALKASLPEHMVPAHLLFLERLPLTANGKLDRRAL 2071
Cdd:PRK07824   301 AVVGDGGPAPTL---EALRAHVARTLDRTAAPRELHVVDELPRRGIGKVDRRAL 351

PLN02330

4-coumarate--CoA ligase-like 1

1592-2071

4.49e-17

4-coumarate--CoA ligase-like 1

Pssm-ID: 215189 [Multi-domain] Cd Length: 546 Bit Score: 87.73 E-value: 4.49e-17

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1592 RALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGYMIEDSGIRLLLT 1671
Cdd:PLN02330    54 KAVTYGEVVRDTRRFAKALRSLGLRKGQVVVVVLPNVAEYGIVALGIMAAGGVFSGANPTALESEIKKQAEAAGAKLIVT 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1672 QRAARERLPlGEGLPCLLLDAEH-----EWAGYPESDPQSAVGVDN-------LAYVIYTSGSTGKPKGTLLPHGNVL-- 1737
Cdd:PLN02330   134 NDTNYGKVK-GLGLPVIVLGEEKiegavNWKELLEAADRAGDTSDNeeilqtdLCALPFSSGTTGISKGVMLTHRNLVan 212

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1738 ---RLFDATRHWFGFSADDAW-SLFHSYAFdfsVWEIFGALLHGGRLVIVPYETSRSpedFLRLLCRERVTVLNQTPSAF 1813
Cdd:PLN02330   213 lcsSLFSVGPEMIGQVVTLGLiPFFHIYGI---TGICCATLRNKGKVVVMSRFELRT---FLNALITQEVSFAPIVPPII 286

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1814 KQLMQVACAGQ-EVPPLALRHVVFGGEALEVQALRPWFERFGDraPRLVNMYGITETTVhVTyrpLSLADLDGGAA---- 1888
Cdd:PLN02330   287 LNLVKNPIVEEfDLSKLKLQAIMTAAAPLAPELLTAFEAKFPG--VQVQEAYGLTEHSC-IT---LTHGDPEKGHGiakk 360

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1889 SPIGEPIPDLSWYLL--DAGLNpVPRGCIGELYVGGAGLARGYLNRPELSCTRFVADpfsttgGRLYrTGDLARYRCDGV 1966
Cdd:PLN02330   361 NSVGFILPNLEVKFIdpDTGRS-LPKNTPGELCVRSQCVMQGYYNNKEETDRTIDED------GWLH-TGDIGYIDDDGD 432

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1967 VEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVV--LPHEGPGATQLVGYVVTQAAPSDpaalRDTLRQALKASLP 2044
Cdd:PLN02330   433 IFIVDRIKELIKYKGFQVAPAELEAILLTHPSVEDAAVvpLPDEEAGEIPAACVVINPKAKES----EEDILNFVAANVA 508

                          490       500
                   ....*....|....*....|....*..
gi 2183974163 2045 EHMVPAHLLFLERLPLTANGKLDRRAL 2071
Cdd:PLN02330   509 HYKKVRVVQFVDSIPKSLSGKIMRRLL 535

PRK09029

O-succinylbenzoic acid--CoA ligase; Provisional

1578-2006

5.90e-17

O-succinylbenzoic acid--CoA ligase; Provisional

Pssm-ID: 236363 [Multi-domain] Cd Length: 458 Bit Score: 86.85 E-value: 5.90e-17

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1578 AAERPRATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRL 1657
Cdd:PRK09029    13 AQVRPQAIALRLNDEVLTWQQLCARIDQLAAGFAQQGVVEGSGVALRGKNSPETLLAYLALLQCGARVLPLNPQLPQPLL 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1658 GYMIEDSGIRLLLTqraarerLPLGEGLPCLLLDAEHEWAGYPESDPQSavgvDNLAYVIYTSGSTGKPKGTLLPHGN-- 1735
Cdd:PRK09029    93 EELLPSLTLDFALV-------LEGENTFSALTSLHLQLVEGAHAVAWQP----QRLATMTLTSGSTGLPKAAVHTAQAhl 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1736 -----VLRLFDatrhwfgFSADDAW----SLFHsyafdFS----VWEifgALLHGGRLVIvpyetsRSPEDFLRLLcrER 1802
Cdd:PRK09029   162 asaegVLSLMP-------FTAQDSWllslPLFH-----VSgqgiVWR---WLYAGATLVV------RDKQPLEQAL--AG 218

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1803 VTVLNQTPSAFKQLMQvacagQEVPPLALRHVVFGG--------EALEVQALRPWferFGdraprlvnmYGITETTVHVT 1874
Cdd:PRK09029   219 CTHASLVPTQLWRLLD-----NRSEPLSLKAVLLGGaaipveltEQAEQQGIRCW---CG---------YGLTEMASTVC 281

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1875 YRPlslADLDGGAaspiGEPIPDLSWYLLDaglnpvprgciGELYVGGAGLARGYLNRPELSctrfvadPFSTTGGrLYR 1954
Cdd:PRK09029   282 AKR---ADGLAGV----GSPLPGREVKLVD-----------GEIWLRGASLALGYWRQGQLV-------PLVNDEG-WFA 335

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2183974163 1955 TGDLARYRcDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVVLP 2006
Cdd:PRK09029   336 TRDRGEWQ-NGELTILGRLDNLFFSGGEGIQPEEIERVINQHPLVQQVFVVP 386

E-C_NRPS

Dual Epimerization/Condensation (E/C) domains of nonribosomal peptide synthetases (NRPSs); ...

1126-1476

8.88e-17

Pssm-ID: 380466 [Multi-domain] Cd Length: 413 Bit Score: 85.57 E-value: 8.88e-17

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1126 RLDPHSAAYNIPVALRLKGPLRRDALQGALDLLVQRHETLRTTFVeHDG--APRQVIHPTLPIAIEERRPP---VAGEDL 1200
Cdd:cd19544     16 LLAEEGDPYLLRSLLAFDSRARLDAFLAALQQVIDRHDILRTAIL-WEGlsEPVQVVWRQAELPVEELTLDpgdDALAQL 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1201 KGLVETEAHRpFDLQRG-PLLRVLLLPLATDECVLVLTLHHIIADGWSMQVLVDElIRVYAALRHDQPPAlaelPIQYAD 1279
Cdd:cd19544     95 RARFDPRRYR-LDLRQApLLRAHVAEDPANGRWLLLLLFHHLISDHTSLELLLEE-IQAILAGRAAALPP----PVPYRN 168

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1280 FAAWQRQwmdGGERERQLDYWVSRLGG-EQP-----LLELPSDrprpqqqshrGRRIG---IPLPAELAEALRRLAQAEQ 1350
Cdd:cd19544    169 FVAQARL---GASQAEHEAFFREMLGDvDEPtapfgLLDVQGD----------GSDITearLALDAELAQRLRAQARRLG 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1351 ---GTLFML----LLAsfqallhRYSGQNDI--------RVGvpianrNREETEGLIGFFVNTQVLRAELDGQlPFRELL 1415
Cdd:cd19544    236 vspASLFHLawalVLA-------RCSGRDDVvfgtvlsgRMQ------GGAGADRALGMFINTLPLRVRLGGR-SVREAV 301

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2183974163 1416 RQVRQAVVEAqghqdLPFEQLvdalqperSLSHA----------PLFQVM--YNHQRDDHRGSRFASLGELEV 1476
Cdd:cd19544    302 RQTHARLAEL-----LRHEHA--------SLALAqrcsgvpaptPLFSALlnYRHSAAAAAAAALAAWEGIEL 361

FACL_like_5

cd05924

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ...

653-1001

9.12e-17

Pssm-ID: 341248 [Multi-domain] Cd Length: 364 Bit Score: 85.13 E-value: 9.12e-17

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  653 PDSLcYAIYTSGSTGQPKGVMVRH----RAL---TNFVCSIARQPGMLARDRLLSVTTFSFDIfglelyVPLARGASMLL 725
Cdd:cd05924      3 ADDL-YILYTGGTTGMPKGVMWRQedifRMLmggADFGTGEFTPSEDAHKAAAAAAGTVMFPA------PPLMHGTGSWT 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  726 A------------SREQAqDPEALLDLVERQGVTVLQAT-PATWRMLCDSER----VDLLRGCTLLCGGEALAEDLAARM 788
Cdd:cd05924     76 AfggllggqtvvlPDDRF-DPEEVWRTIEKHKVTSMTIVgDAMARPLIDALRdagpYDLSSLFAISSGGALLSPEVKQGL 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  789 RGL--SASTWNLYGPTET--TIWSARFRLGEEARPFLggpLENTALYILDSEMNPCPPGVAGELLIGGDGL-ARGYHRRP 863
Cdd:cd05924    155 LELvpNITLVDAFGSSETgfTGSGHSAGSGPETGPFT---RANPDTVVLDDDGRVVPPGSGGVGWIARRGHiPLGYYGDE 231

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  864 GLTAERFlpdpFAADGSRLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQPGVA-G 942
Cdd:cd05924    232 AKTAETF----PEVDGVRYAVPGDRATVEADGTVTLLGRGSVCINTGGEKVFPEEVEEALKSHPAVYDVLVVGRPDERwG 307

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2183974163  943 PTLVAYLVPTEAALVDAEsarqqELRSALKNSLLAvlpdYMVPAHMLLLENLPLTPNGK 1001
Cdd:cd05924    308 QEVVAVVQLREGAGVDLE-----ELREHCRTRIAR----YKLPKQVVFVDEIERSPAGK 357

LCL_NRPS-like

LCL-type Condensation domain of nonribosomal peptide synthetases (NRPSs) and similar domains; ...

2204-2431

1.02e-16

Pssm-ID: 380463 [Multi-domain] Cd Length: 433 Bit Score: 85.55 E-value: 1.02e-16

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2204 ALDGTLLETALQALLAHHDALRLGFRLEDGTWRAEHRAVEAGEVLLWQQSVADGQALEALAEQVQRSLDLGSGPLLRALL 2283
Cdd:cd19540     35 ALDVDALRAALADVVARHESLRTVFPEDDGGPYQVVLPAAEARPDLTVVDVTEDELAARLAEAARRGFDLTAELPLRARL 114

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2284 ATLGDGSQRLLLVIHHLVVDGVSWRILLEDLQTAYRQLQAGQA---VALPAKTSAFKAWAERLQAHARDGG--LEGERGY 2358
Cdd:cd19540    115 FRLGPDEHVLVLVVHHIAADGWSMAPLARDLATAYAARRAGRApdwAPLPVQYADYALWQRELLGDEDDPDslAARQLAY 194

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2183974163 2359 WLAQLEGV--STELPCDDREGAqsVRHVRSARTELT-EEATRRLLQEAPAAYRTQVNDLLLTALARVIGRWTGQAD 2431
Cdd:cd19540    195 WRETLAGLpeELELPTDRPRPA--VASYRGGTVEFTiDAELHARLAALAREHGATLFMVLHAALAVLLSRLGAGDD 268

AFD_YhfT-like

cd17633

fatty acid-CoA ligase VraA; This family of acyl-CoA ligases includes Bacillus subtilis YhfT, ...

655-1004

1.05e-16

Pssm-ID: 341288 [Multi-domain] Cd Length: 320 Bit Score: 83.99 E-value: 1.05e-16

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  655 SLCYAIYTSGSTGQPKGVMVRHRA-LTNFVCSiarQPGML--ARDRLLSVTTFSFDIFGLELYVPLARGASMLLASReqa 731
Cdd:cd17633      1 NPFYIGFTSGTTGLPKAYYRSERSwIESFVCN---EDLFNisGEDAILAPGPLSHSLFLYGAISALYLGGTFIGQRK--- 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  732 QDPEALLDLVERQGVTVLQATPATWRMLCDSERVDL-LRgcTLLCGGEALAEDLAARMRGLS--ASTWNLYGPTETTIWS 808
Cdd:cd17633     75 FNPKSWIRKINQYNATVIYLVPTMLQALARTLEPESkIK--SIFSSGQKLFESTKKKLKNIFpkANLIEFYGTSELSFIT 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  809 ARFRlGEEARPF-LGGPLENTALYILDSEmnpcpPGVAGELLIGGDGLARGYHRRPGLTAERFlpdpfaadgsrlYRTGD 887
Cdd:cd17633    153 YNFN-QESRPPNsVGRPFPNVEIEIRNAD-----GGEIGKIFVKSEMVFSGYVRGGFSNPDGW------------MSVGD 214

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  888 LARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQPGVAGPTLVaylvpteAALVDAESARQQEL 967
Cdd:cd17633    215 IGYVDEEGYLYLVGRESDMIIIGGINIFPTEIESVLKAIPGIEEAIVVGIPDARFGEIA-------VALYSGDKLTYKQL 287

                          330       340       350
                   ....*....|....*....|....*....|....*..
gi 2183974163  968 RSALKNSLLAvlpdYMVPAHMLLLENLPLTPNGKINR 1004
Cdd:cd17633    288 KRFLKQKLSR----YEIPKKIIFVDSLPYTSSGKIAR 320

LCL_NRPS

LCL-type Condensation domain of non-ribosomal peptide synthetases (NRPSs) and similar domains; ...

2205-2403

1.54e-16

Pssm-ID: 380461 [Multi-domain] Cd Length: 432 Bit Score: 85.01 E-value: 1.54e-16

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2205 LDGTLLETALQALLAHHDALRLGFRLEDGTWRAEHRAVEAGEVLLWQQSVADGQALEALAEQVQRSLDLGSGPLLRALLA 2284
Cdd:cd19538     36 LDVQALQQALYDVVERHESLRTVFPEEDGVPYQLILEEDEATPKLEIKEVDEEELESEINEAVRYPFDLSEEPPFRATLF 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2285 TLGDGSQRLLLVIHHLVVDGVSWRILLEDLQTAYRQLQAGQA---VALPAKTSAFKAWAERLQAHARDGG--LEGERGYW 2359
Cdd:cd19538    116 ELGENEHVLLLLLHHIAADGWSLAPLTRDLSKAYRARCKGEApelAPLPVQYADYALWQQELLGDESDPDslIARQLAYW 195

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 2183974163 2360 LAQLEGV--STELPCDDREGAQSVRHVRSARTELTEEATRRLLQEA 2403
Cdd:cd19538    196 KKQLAGLpdEIELPTDYPRPAESSYEGGTLTFEIDSELHQQLLQLA 241

PRK05677

long-chain-fatty-acid--CoA ligase; Validated

505-1007

1.79e-16

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 168170 [Multi-domain] Cd Length: 562 Bit Score: 85.97 E-value: 1.79e-16

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  505 EYPAGQGVhrlFEAQAGLTPDAPALLFGEERLSYAELNALANRLAWRLREEgvgSDVLVG--IALErgVPMV----VALL 578
Cdd:PRK05677    22 EYPNIQAV---LKQSCQRFADKPAFSNLGKTLTYGELYKLSGAFAAWLQQH---TDLKPGdrIAVQ--LPNVlqypVAVF 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  579 AVLKAGGAYVPLDPQYPADRLQYMIDDSGLRLL--LSQQSVLAR--LPQSDGLQSL------LLDDLERLV--------- 639
Cdd:PRK05677    94 GAMRAGLIVVNTNPLYTAREMEHQFNDSGAKALvcLANMAHLAEkvLPKTGVKHVIvtevadMLPPLKRLLinavvkhvk 173

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  640 ---------------------HGYPAENPDLpeAPDSLCYAIYTSGSTGQPKGVMVRHRaltNFVCSIARQPGMLARD-- 696
Cdd:PRK05677   174 kmvpayhlpqavkfndalakgAGQPVTEANP--QADDVAVLQYTGGTTGVAKGAMLTHR---NLVANMLQCRALMGSNln 248

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  697 ----------RLLSVTTFSFDIFGLELYvplarGASMLLASreQAQDPEALLDLVERQGVTVLQATPATWRMLCDSE--- 763
Cdd:PRK05677   249 egceiliaplPLYHIYAFTFHCMAMMLI-----GNHNILIS--NPRDLPAMVKELGKWKFSGFVGLNTLFVALCNNEafr 321

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  764 RVDLLRGCTLLCGGEALAEDLAARMRGLSA-STWNLYGPTETTIWSA-----RFRLGEearpfLGGPLENTALYILDSEM 837
Cdd:PRK05677   322 KLDFSALKLTLSGGMALQLATAERWKEVTGcAICEGYGMTETSPVVSvnpsqAIQVGT-----IGIPVPSTLCKVIDDDG 396

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  838 NPCPPGVAGELLIGGDGLARGYHRRPGLTAERflpdpFAADGsrLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELG 917
Cdd:PRK05677   397 NELPLGEVGELCVKGPQVMKGYWQRPEATDEI-----LDSDG--WLKTGDIALIQEDGYMRIVDRKKDMILVSGFNVYPN 469

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  918 EIETRLLEQDSVREAVVVAQPGVA-GPTLVAYLVPTEAALVDAEsarqqELRSALKNSLLAvlpdYMVPAHMLLLENLPL 996
Cdd:PRK05677   470 ELEDVLAALPGVLQCAAIGVPDEKsGEAIKVFVVVKPGETLTKE-----QVMEHMRANLTG----YKVPKAVEFRDELPT 540

                          570
                   ....*....|.
gi 2183974163  997 TPNGKINRKAL 1007
Cdd:PRK05677   541 TNVGKILRREL 551

LC_FACS_euk1

cd17639

Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS), including fungal proteins; The ...

653-956

1.79e-16

Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS), including fungal proteins; The members of this family are eukaryotic fatty acid CoA synthetases (EC 6.2.1.3) that activate fatty acids with chain lengths of 12 to 20 and includes fungal proteins. They act on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions. Organisms tend to have multiple isoforms of LC-FACS genes with multiple splice variants. For example, nine genes are found in Arabidopsis and six genes are expressed in mammalian cells. In Schizosaccharomyces pombe, lcf1 gene encodes a new fatty acyl-CoA synthetase that preferentially recognizes myristic acid as a substrate.

Pssm-ID: 341294 [Multi-domain] Cd Length: 507 Bit Score: 85.73 E-value: 1.79e-16

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  653 PDSLCYAIYTSGSTGQPKGVMVRHRaltNFVCSIArqpGMLAR--------DRLLSvttfsfdifglelYVPLA------ 718
Cdd:cd17639     87 PDDLACIMYTSGSTGNPKGVMLTHG---NLVAGIA---GLGDRvpellgpdDRYLA-------------YLPLAhifela 147

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  719 -------RGASMLLASreqaqdPEALL---------DLVERQGvTVLQATPATW-------------------------- 756
Cdd:cd17639    148 aenvclyRGGTIGYGS------PRTLTdkskrgckgDLTEFKP-TLMVGVPAIWdtirkgvlaklnpmgglkrtlfwtay 220

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  757 -------RMLCDSERVDL-------------LRGCtlLCGGEALAEDLAARMRGLSASTWNLYGPTETTIWSARFRLGEE 816
Cdd:cd17639    221 qsklkalKEGPGTPLLDElvfkkvraalggrLRYM--LSGGAPLSADTQEFLNIVLCPVIQGYGLTETCAGGTVQDPGDL 298

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  817 ARPFLGGPLENTALYILDSE------MNPCPpgvAGELLIGGDGLARGYHRRPGLTAERFLPDpfaadgsRLYRTGDLAR 890
Cdd:cd17639    299 ETGRVGPPLPCCEIKLVDWEeggystDKPPP---RGEILIRGPNVFKGYYKNPEKTKEAFDGD-------GWFHTGDIGE 368

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2183974163  891 YRADGVIEYLGRIDHQVKIR-GFRIELGEIETRLLEQDSVREAVVVAQPgvAGPTLVAYLVPTEAAL 956
Cdd:cd17639    369 FHPDGTLKIIDRKKDLVKLQnGEYIALEKLESIYRSNPLVNNICVYADP--DKSYPVAIVVPNEKHL 433

AcpA

COG3433

Acyl carrier protein/domain [Lipid transport and metabolism, Secondary metabolites ...

830-1099

1.99e-16

Acyl carrier protein/domain [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism];

Pssm-ID: 442659 [Multi-domain] Cd Length: 295 Bit Score: 82.88 E-value: 1.99e-16

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  830 LYILDSEMNPCPPGVAGELLIGGDGLARGYHRRPGLTAERFLPDPFAADGSRLYRTGDLARYRADGVIEYLGRIDHQVKI 909
Cdd:COG3433     26 QARALLLIVDLQGYFGGFGGEGGLLGAGLLLRIRLLAAAARAPFIPVPYPAQPGRQADDLRLLLRRGLGPGGGLERLVQQ 105

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  910 RGFRIELGEIET-----RLLEQDSVREAVVVAQPGVAGPTLVAYLVPTEAALVDAESARQqelrsalknsllAVLPDYMV 984
Cdd:COG3433    106 VVIRAERGEEEElllvlRAAAVVRVAVLAALRGAGVGLLLIVGAVAALDGLAAAAALAAL------------DKVPPDVV 173

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  985 PAHMLLLENLPLTPNGKINRKALPLPDASAVRDAHVAPEGELERA-----MAAIWSEVLKLG--HIGRDDNFFELGGHSL 1057
Cdd:COG3433    174 AASAVVALDALLLLALKVVARAAPALAAAEALLAAASPAPALETAlteeeLRADVAELLGVDpeEIDPDDNLFDLGLDSI 253

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|..
gi 2183974163 1058 LVTQVVSRVRRRlDLQVPLRTLFEHSTLRAYAQAVAQLAPAA 1099
Cdd:COG3433    254 RLMQLVERWRKA-GLDVSFADLAEHPTLAAWWALLAAAQAAA 294

FACL_FadD13-like

cd17631

fatty acyl-CoA synthetase, including FadD13; This family contains fatty acyl-CoA synthetases, ...

3091-3182

2.33e-16

Pssm-ID: 341286 [Multi-domain] Cd Length: 435 Bit Score: 84.58 E-value: 2.33e-16

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3091 FEEQVERTPTAPALAFGEERLDYAELNRRANRLAHALIERGIGA-DRlVGVAMERSIEMVVALMAILKAGGAYVPVDPEY 3169
Cdd:cd17631      1 LRRRARRHPDRTALVFGGRSLTYAELDERVNRLAHALRALGVAKgDR-VAVLSKNSPEFLELLFAAARLGAVFVPLNFRL 79

                           90
                   ....*....|...
gi 2183974163 3170 PEERQAYMLEDSG 3182
Cdd:cd17631     80 TPPEVAYILADSG 92

PtmA

cd17636

long-chain fatty acid CoA ligase (FadD); This family contains fatty acid CoA ligases, ...

657-960

2.56e-16

Pssm-ID: 341291 [Multi-domain] Cd Length: 331 Bit Score: 83.12 E-value: 2.56e-16

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  657 CYAIYTSGSTGQPKGVMVRHRAL------TNFVCSIARQPGMLARDRL-----LSVTTFSFDIFGLELYVPLArgasmll 725
Cdd:cd17636      3 VLAIYTAAFSGRPNGALLSHQALlaqalvLAVLQAIDEGTVFLNSGPLfhigtLMFTLATFHAGGTNVFVRRV------- 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  726 asreqaqDPEALLDLVERQGVTVLQATPATwrmlcdserVDLLRgctllcggEALAE---DLAARMRGLSASTWNLYGPT 802
Cdd:cd17636     76 -------DAEEVLELIEAERCTHAFLLPPT---------IDQIV--------ELNADglyDLSSLRSSPAAPEWNDMATV 131

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  803 ETTIWSARFR---------------LGEEARPFLGGPLENTALYILDSEMNPCPPGVAGELLIGGDGLARGYHRRPGLTA 867
Cdd:cd17636    132 DTSPWGRKPGgygqtevmglatfaaLGGGAIGGAGRPSPLVQVRILDEDGREVPDGEVGEIVARGPTVMAGYWNRPEVNA 211

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  868 ERFlpdpfaADGsrLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVaqpGVAGPTLV- 946
Cdd:cd17636    212 RRT------RGG--WHHTNDLGRREPDGSLSFVGPKTRMIKSGAENIYPAEVERCLRQHPAVADAAVI---GVPDPRWAq 280

                          330
                   ....*....|....*..
gi 2183974163  947 ---AYLVPTEAALVDAE 960
Cdd:cd17636    281 svkAIVVLKPGASVTEA 297

Firefly_Luc

cd17642

insect luciferase, similar to plant 4-coumarate: CoA ligases; This family contains insect ...

502-1007

2.67e-16

Pssm-ID: 341297 [Multi-domain] Cd Length: 532 Bit Score: 85.27 E-value: 2.67e-16

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  502 PASEYPAGQGVHRLFEAQAGLtPDAPALL--FGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLA 579
Cdd:cd17642     10 PLEDGTAGEQLHKAMKRYASV-PGTIAFTdaHTGVNYSYAEYLEMSVRLAEALKKYGLKQNDRIAVCSENSLQFFLPVIA 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  580 VLKAGGAYVPLDPQYPADRLQYMIDDSGLRLLLSQ----QSVLARLPQSDGLQSLLLDDLERLVHGYPAEN--------- 646
Cdd:cd17642     89 GLFIGVGVAPTNDIYNERELDHSLNISKPTIVFCSkkglQKVLNVQKKLKIIKTIIILDSKEDYKGYQCLYtfitqnlpp 168

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  647 --------PDLPEAPDSLCYAIYTSGSTGQPKGVMVRHR-ALTNFvcSIARQP----GMLARDRLLSVTTF--SFDIFGL 711
Cdd:cd17642    169 gfneydfkPPSFDRDEQVALIMNSSGSTGLPKGVQLTHKnIVARF--SHARDPifgnQIIPDTAILTVIPFhhGFGMFTT 246

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  712 ELYvpLARGASMLLASReqaQDPEALLDLVERQGVTVLQATPATWRMLCDSERV---DLLRGCTLLCGGEALA---EDLA 785
Cdd:cd17642    247 LGY--LICGFRVVLMYK---FEEELFLRSLQDYKVQSALLVPTLFAFFAKSTLVdkyDLSNLHEIASGGAPLSkevGEAV 321

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  786 ARMRGLSASTWNlYGPTETTiwSARFRLGEE-ARPFLGG---PLENTALYILDSEmNPCPPGVAGELLIGGDGLARGYHR 861
Cdd:cd17642    322 AKRFKLPGIRQG-YGLTETT--SAILITPEGdDKPGAVGkvvPFFYAKVVDLDTG-KTLGPNERGELCVKGPMIMKGYVN 397

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  862 RPGLTAErflpdpfAADGSRLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAvvvaqpGVA 941
Cdd:cd17642    398 NPEATKA-------LIDKDGWLHSGDIAYYDEDGHFFIVDRLKSLIKYKGYQVPPAELESILLQHPKIFDA------GVA 464

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2183974163  942 G-PTLVAYLVPteAALVDAESARQQElrsalKNSLLAVLPDYMVPAHML-----LLENLPLTPNGKINRKAL 1007
Cdd:cd17642    465 GiPDEDAGELP--AAVVVLEAGKTMT-----EKEVMDYVASQVSTAKRLrggvkFVDEVPKGLTGKIDRRKI 529

FACL_like_1

cd05910

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ...

535-972

3.91e-16

Pssm-ID: 341236 [Multi-domain] Cd Length: 457 Bit Score: 84.05 E-value: 3.91e-16

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  535 RLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQYMIDDSglrlllsq 614
Cdd:cd05910      2 RLSFRELDERSDRIAQGLTAYGIRRGMRAVLMVPPGPDFFALTFALFKAGAVPVLIDPGMGRKNLKQCLQEA-------- 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  615 qsvlarlpqsdglqslllddlerlvhgypaeNPD----LPEAPDSLCyAIYTSGSTGQPKGVMVRHRALTNFVCSIARQP 690
Cdd:cd05910     74 -------------------------------EPDafigIPKADEPAA-ILFTSGSTGTPKGVVYRHGTFAAQIDALRQLY 121

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  691 GMLARDRLLSvtTFS-FDIFGLELyvPLARGASMLLASREQAQDPEALLDLVERQGVTVLQATPATWRML---CDSERVD 766
Cdd:cd05910    122 GIRPGEVDLA--TFPlFALFGPAL--GLTSVIPDMDPTRPARADPQKLVGAIRQYGVSIVFGSPALLERVaryCAQHGIT 197

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  767 LLRGCTLLCGGEALAEDLAARMRGL---SASTWNLYGPTE----TTIWSARFRLGEEARP------FLGGPLENTALYIL 833
Cdd:cd05910    198 LPSLRRVLSAGAPVPIALAARLRKMlsdEAEILTPYGATEalpvSSIGSRELLATTTAATsggagtCVGRPIPGVRVRII 277

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  834 DSEMNP---------CPPGVAGELLIGGDGLARGYHRRPGLTAERFLPDPfaaDGSRLYRTGDLARYRADGVIEYLGRID 904
Cdd:cd05910    278 EIDDEPiaewddtleLPRGEIGEITVTGPTVTPTYVNRPVATALAKIDDN---SEGFWHRMGDLGYLDDEGRLWFCGRKA 354

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2183974163  905 HQVKIRGFRIELGEIETRLLEQDSV-REAVV-VAQPGVAGPTLVAYLVPteaaLVDAESAR-QQELRSALK 972
Cdd:cd05910    355 HRVITTGGTLYTEPVERVFNTHPGVrRSALVgVGKPGCQLPVLCVEPLP----GTITPRARlEQELRALAK 421

FATP_FACS

cd05940

Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its ...

533-1001

5.25e-16

Pssm-ID: 341263 [Multi-domain] Cd Length: 449 Bit Score: 83.56 E-value: 5.25e-16

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  533 EERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQYMIDDSGLRLLL 612
Cdd:cd05940      1 DEALTYAELDAMANRYARWLKSLGLKPGDVVALFMENRPEYVLLWLGLVKIGAVAALINYNLRGESLAHCLNVSSAKHLV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  613 SQqsvlarlpqsdglqslllddlerlvhgypaenpdlpeapdsLCYAIYTSGSTGQPKGVMVRHRALTNFVCSIARQPGM 692
Cdd:cd05940     81 VD-----------------------------------------AALYIYTSGTTGLPKAAIISHRRAWRGGAFFAGSGGA 119

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  693 LARDRLLSVttfsfdifgLELY----------VPLARGASMLLASREQAQDpeaLLDLVERQGVTVLQATPATWRMLCDS 762
Cdd:cd05940    120 LPSDVLYTC---------LPLYhstalivgwsACLASGATLVIRKKFSASN---FWDDIRKYQATIFQYIGELCRYLLNQ 187

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  763 ERVDLLRG--CTLLCGGealaedlaarmrGLSASTWN-------------LYGPTETTIWSARF--RLGEEAR-PFLGGP 824
Cdd:cd05940    188 PPKPTERKhkVRMIFGN------------GLRPDIWEefkerfgvpriaeFYAATEGNSGFINFfgKPGAIGRnPSLLRK 255

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  825 LENTALYILDSE-----------MNPCPPGVAGELL--IGGDGLARGYhRRPGLTAERFLPDPFaADGSRLYRTGDLARY 891
Cdd:cd05940    256 VAPLALVKYDLEsgepirdaegrCIKVPRGEPGLLIsrINPLEPFDGY-TDPAATEKKILRDVF-KKGDAWFNTGDLMRL 333

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  892 RADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVV--VAQPGVAGPTLVaylvpteAALVDAESarQQELRS 969
Cdd:cd05940    334 DGEGFWYFVDRLGDTFRWKGENVSTTEVAAVLGAFPGVEEANVygVQVPGTDGRAGM-------AAIVLQPN--EEFDLS 404

                          490       500       510
                   ....*....|....*....|....*....|..
gi 2183974163  970 ALKNSLLAVLPDYMVPAHMLLLENLPLTPNGK 1001
Cdd:cd05940    405 ALAAHLEKNLPGYARPLFLRLQPEMEITGTFK 436

PRK08751

long-chain fatty acid--CoA ligase;

506-1007

6.85e-16

long-chain fatty acid--CoA ligase;

Pssm-ID: 181546 [Multi-domain] Cd Length: 560 Bit Score: 84.16 E-value: 6.85e-16

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  506 YPAG----------QGVHRLFEAQAGLTPDAPALLFGEERLSYAELNALANRLA-WRLREEGVGSDVLVGIALERGVPMV 574
Cdd:PRK08751    11 YPAGvaaeidleqfRTVAEVFATSVAKFADRPAYHSFGKTITYREADQLVEQFAaYLLGELQLKKGDRVALMMPNCLQYP 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  575 VALLAVLKAGGAYVPLDPQYPADRLQYMIDDSGLRLLL-------SQQSVLARLPQ----SDGLQSLL-----------L 632
Cdd:PRK08751    91 IATFGVLRAGLTVVNVNPLYTPRELKHQLIDSGASVLVvidnfgtTVQQVIADTPVkqviTTGLGDMLgfpkaalvnfvV 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  633 DDLERLVHGYPAEN----------------PDLPEAPDSLCYAIYTSGSTGQPKGVMVRHRaltNFVCSiarqpgMLARD 696
Cdd:PRK08751   171 KYVKKLVPEYRINGairfrealalgrkhsmPTLQIEPDDIAFLQYTGGTTGVAKGAMLTHR---NLVAN------MQQAH 241

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  697 RLLSVTTFSFD-----IFGLELYVPLARGASMLLASR--------EQAQDPEALLDLVERQGVTVLQATPATWRMLCDSE 763
Cdd:PRK08751   242 QWLAGTGKLEEgcevvITALPLYHIFALTANGLVFMKiggcnhliSNPRDMPGFVKELKKTRFTAFTGVNTLFNGLLNTP 321

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  764 RVDLLRGCTLLC---GGEALAEDLAARMRGLSASTW-NLYGPTETTIWSARFRLG-EEARPFLGGPLENTALYILDSEMN 838
Cdd:PRK08751   322 GFDQIDFSSLKMtlgGGMAVQRSVAERWKQVTGLTLvEAYGLTETSPAACINPLTlKEYNGSIGLPIPSTDACIKDDAGT 401

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  839 PCPPGVAGELLIGGDGLARGYHRRPGLTAErflpdpfAADGSRLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGE 918
Cdd:PRK08751   402 VLAIGEIGELCIKGPQVMKGYWKRPEETAK-------VMDADGWLHTGDIARMDEQGFVYIVDRKKDMILVSGFNVYPNE 474

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  919 IETrlleqdsvreaVVVAQPGVAgpTLVAYLVPTEAA--LVDAESARQQELRSA--LKNSLLAVLPDYMVPAHMLLLENL 994
Cdd:PRK08751   475 IED-----------VIAMMPGVL--EVAAVGVPDEKSgeIVKVVIVKKDPALTAedVKAHARANLTGYKQPRIIEFRKEL 541

                          570
                   ....*....|...
gi 2183974163  995 PLTPNGKINRKAL 1007
Cdd:PRK08751   542 PKTNVGKILRREL 554

FC-FACS_FadD_like

cd05936

Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; This ...

3089-3183

7.64e-16

Pssm-ID: 341259 [Multi-domain] Cd Length: 468 Bit Score: 83.38 E-value: 7.64e-16

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3089 RLFEEQVERTPTAPALAFGEERLDYAELNRRANRLAHALIERGIGA-DRlVGVAMERSIEMVVALMAILKAGGAYVPVDP 3167
Cdd:cd05936      3 DLLEEAARRFPDKTALIFMGRKLTYRELDALAEAFAAGLQNLGVQPgDR-VALMLPNCPQFPIAYFGALKAGAVVVPLNP 81

                           90
                   ....*....|....*.
gi 2183974163 3168 EYPEERQAYMLEDSGV 3183
Cdd:cd05936     82 LYTPRELEHILNDSGA 97

AFD_CAR-like

cd17632

adenylation domain of carboxylic acid reductase (CAR); This family contains the adenylation ...

470-1000

8.14e-16

adenylation domain of carboxylic acid reductase (CAR); This family contains the adenylation domain of carboxylic acid reductase enzymes (CARs), and performs an equivalent function to that of the ANL superfamily of adenylating enzymes. It takes a carboxylic acid substrate and ATP, and produces an AMP-acyl phosphoester intermediate, releasing pyrophosphate. Kinetic analysis using various substrates shows that this enzyme has a broad but similar substrate specificity, preferring electron-rich acids. This suggests that attack by the carboxylate on the alpha-phosphate of adenosine triphosphate (ATP) is the step that determines the substrate specificity and reaction kinetics. CAR is an important enzyme for use as a biocatalyst providing regiospecific route to aldehydes from their respective carboxylic acids.

Pssm-ID: 341287 [Multi-domain] Cd Length: 588 Bit Score: 84.04 E-value: 8.14e-16

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  470 LEAVVAEPRRRLGDLPLLDAE------ERATLLQRSRLPASEYPAGQGVHRLFEAQAGLTpdapallfgeerlsYAELNA 543
Cdd:cd17632     10 LEAVTEAIRRPGLRLAQIIATvmtgyaDRPALGQRATELVTDPATGRTTLRLLPRFETIT--------------YAELWE 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  544 LANRLAWRLR-EEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQYMIDDSGLRLL--------LSQ 614
Cdd:cd17632     76 RVGAVAAAHDpEQPVRPGDFVAVLGFTSPDYATVDLALTRLGAVSVPLQAGASAAQLAPILAETEPRLLavsaehldLAV 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  615 QSVL----------------------------ARLPQSDGLQSLLLDDLERLVHGYPAENPDLPEAPDSLCYAIYTSGST 666
Cdd:cd17632    156 EAVLeggtpprlvvfdhrpevdahraalesarERLAAVGIPVTTLTLIAVRGRDLPPAPLFRPEPDDDPLALLIYTSGST 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  667 GQPKGVMVRHRALTNFvcsiARQPGMLARDRLLSVTTFSF----DIFG-LELYVPLARGASMLLASreqAQDPEALLDLV 741
Cdd:cd17632    236 GTPKGAMYTERLVATF----WLKVSSIQDIRPPASITLNFmpmsHIAGrISLYGTLARGGTAYFAA---ASDMSTLFDDL 308

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  742 ERQGVTVLQATPATWRML-------------------CDSERV------DLLRG--CTLLCGGEALAEDLAARMRG-LSA 793
Cdd:cd17632    309 ALVRPTELFLVPRVCDMLfqryqaeldrrsvagadaeTLAERVkaelreRVLGGrlLAAVCGSAPLSAEMKAFMESlLDL 388

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  794 STWNLYGPTETtiwSARFRLGEEARPflggPlentalyILDSEMNPCP---------PGVAGELLIGGDGLARGYHRRPG 864
Cdd:cd17632    389 DLHDGYGSTEA---GAVILDGVIVRP----P-------VLDYKLVDVPelgyfrtdrPHPRGELLVKTDTLFPGYYKRPE 454

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  865 LTAERFLPDPFaadgsrlYRTGDLARYRADGVIEYLGRIDHQVKirgfrIELGEIET--RLleqdsvrEAVVVAQPGV-- 940
Cdd:cd17632    455 VTAEVFDEDGF-------YRTGDVMAELGPDRLVYVDRRNNVLK-----LSQGEFVTvaRL-------EAVFAASPLVrq 515

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2183974163  941 -------AGPTLVAYLVPTEAALVDAESARqqeLRSALKNSLLAV-----LPDYMVPAHmLLLENLPLTP-NG 1000
Cdd:cd17632    516 ifvygnsERAYLLAVVVPTQDALAGEDTAR---LRAALAESLQRIareagLQSYEIPRD-FLIETEPFTIaNG 584

PRK07768

long-chain-fatty-acid--CoA ligase; Validated

1576-2070

8.69e-16

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 236091 [Multi-domain] Cd Length: 545 Bit Score: 83.51 E-value: 8.69e-16

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1576 RQAAERPRA--TAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYP 1653
Cdd:PRK07768    10 ANARTSPRGmvTGEPDAPVRHTWGEVHERARRIAGGLAAAGVGPGDAVAVLAGAPVEIAPTAQGLWMRGASLTMLHQPTP 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1654 SDRLGYMIEDSGIRL-LLTQRAARERLPLGEGLPCL------LLDAEHEWAGYPESDPQsaVGVDNLAYVIYTSGSTGKP 1726
Cdd:PRK07768    90 RTDLAVWAEDTLRVIgMIGAKAVVVGEPFLAAAPVLeekgirVLTVADLLAADPIDPVE--TGEDDLALMQLTSGSTGSP 167

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1727 KGTLLPHGNVLRLFDATRHWFGFSADD----AW-SLFHSYAFD--FSVWEIFGALLhggrLVIVPYETSRSPEDFLRLLC 1799
Cdd:PRK07768   168 KAVQITHGNLYANAEAMFVAAEFDVETdvmvSWlPLFHDMGMVgfLTVPMYFGAEL----VKVTPMDFLRDPLLWAELIS 243

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1800 RERVTVL---NQTPSAFKQLMQVACAGQEVPPLALRHVVFGGEALEVQALRPWFE---RFGDRAPRLVNMYGITETTVHV 1873
Cdd:PRK07768   244 KYRGTMTaapNFAYALLARRLRRQAKPGAFDLSSLRFALNGAEPIDPADVEDLLDagaRFGLRPEAILPAYGMAEATLAV 323

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1874 TYRPLSL--------ADL----------DGGAASP---IGEPIPDLSWYLLDAGLNPVPRGCIGELYVGGAGLARGYLnr 1932
Cdd:PRK07768   324 SFSPCGAglvvdevdADLlaalrravpaTKGNTRRlatLGPPLPGLEVRVVDEDGQVLPPRGVGVIELRGESVTPGYL-- 401

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1933 pelsctrfvadpfsTTGGRL--------YRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEaRLLA-----QPGV 1999
Cdd:PRK07768   402 --------------TMDGFIpaqdadgwLDTGDLGYLTEEGEVVVCGRVKDVIIMAGRNIYPTDIE-RAAArvegvRPGN 466

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2183974163 2000 AEAVVLPHEGPGATQLVgyVVTQAAPSDPAALRDTLRQALKASLPEHMV-PAHLLFLE--RLPLTANGKLDRRA 2070
Cdd:PRK07768   467 AVAVRLDAGHSREGFAV--AVESNAFEDPAEVRRIRHQVAHEVVAEVGVrPRNVVVLGpgSIPKTPSGKLRRAN 538

PLN03102

acyl-activating enzyme; Provisional

1564-2093

9.97e-16

acyl-activating enzyme; Provisional

Pssm-ID: 215576 [Multi-domain] Cd Length: 579 Bit Score: 83.53 E-value: 9.97e-16

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1564 FTPASCLHRlierqAAE-RPRATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAG 1642
Cdd:PLN03102    14 LTPITFLKR-----ASEcYPNRTSIIYGKTRFTWPQTYDRCCRLAASLISLNITKNDVVSVLAPNTPAMYEMHFAVPMAG 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1643 GAYVPLDPRYPSDRLGYMIEDSGIRLLLTQRA----ARERLPL------GEGLPCLLL------------DAEHE---WA 1697
Cdd:PLN03102    89 AVLNPINTRLDATSIAAILRHAKPKILFVDRSfeplAREVLHLlssedsNLNLPVIFIheidfpkrpsseELDYEcliQR 168

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1698 GYP-------------ESDPQSavgvdnlayVIYTSGSTGKPKGTLLPH-GNVLRLFDATRHW-FGFSADDAWSL--FHS 1760
Cdd:PLN03102   169 GEPtpslvarmfriqdEHDPIS---------LNYTSGTTADPKGVVISHrGAYLSTLSAIIGWeMGTCPVYLWTLpmFHC 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1761 YAFDFSvWeifGALLHGGRLVIVPYETSrsPEDFlRLLCRERVTVLNQTPSAFKQLMQVACAGQ--EVPPLalrHVVFGG 1838
Cdd:PLN03102   240 NGWTFT-W---GTAARGGTSVCMRHVTA--PEIY-KNIEMHNVTHMCCVPTVFNILLKGNSLDLspRSGPV---HVLTGG 309

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1839 EALEVqALRPWFERFGDRaprLVNMYGITETTVHVTY------------------------RPLSLADLDGGAASPigep 1894
Cdd:PLN03102   310 SPPPA-ALVKKVQRLGFQ---VMHAYGLTEATGPVLFcewqdewnrlpenqqmelkarqgvSILGLADVDVKNKET---- 381

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1895 ipdlswylldagLNPVPRG--CIGELYVGGAGLARGYLNRPELSCTRFvadpfstTGGRLyRTGDLARYRCDGVVEYVGR 1972
Cdd:PLN03102   382 ------------QESVPRDgkTMGEIVIKGSSIMKGYLKNPKATSEAF-------KHGWL-NTGDVGVIHPDGHVEIKDR 441

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1973 IDHQVKIRGFRIELGEIEARLLAQPGVAEAVV--LPHEGPGATQlVGYVVTQAAPSDPAALRDTLR-------QALKASL 2043
Cdd:PLN03102   442 SKDIIISGGENISSVEVENVLYKYPKVLETAVvaMPHPTWGETP-CAFVVLEKGETTKEDRVDKLVtrerdliEYCRENL 520

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2044 PEHMVPAHLLFLERLPLTANGKLDRRALPAPDASRLQRDYTAPRSELEQR 2093
Cdd:PLN03102   521 PHFMCPRKVVFLQELPKNGNGKILKPKLRDIAKGLVVEDEDNVIKKVHQR 570

C_NRPS-like

Condensation family domain with an atypical active site motif; Condensation (C) domains of ...

2639-2941

1.10e-15

Pssm-ID: 380460 [Multi-domain] Cd Length: 395 Bit Score: 82.23 E-value: 1.10e-15

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2639 PLSPMQQGMLFHslYQQNSG------DYINQMRLDVeglDPQRFREAWQAALDAHEVLRSGFlwqgaLEKPLQLVRK--- 2709
Cdd:cd19537      3 ALSPIEREWWHK--YQLSTGtssfnvSFACRLSGDV---DRDRLASAWNTVLARHRILRSRY-----VPRDGGLRRSyss 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2710 ---RVEVPFSVHDWRdradlaealdalaagEAGLGFELAEAPLLRLVLVRTgerrhHLIYTNHHILMDGWSNSQLLGEVL 2786
Cdd:cd19537     73 sppRVQRVDTLDVWK---------------EINRPFDLEREDPIRVFISPD-----TLLVVMSHIICDLTTLQLLLREVS 132

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2787 QRYRGETPSRSDGRYRDYIAWlQRQDAGRTEAFWKQRLQrlGEPTLLVPAFAhGVRGAEGhADRYRQLDVTTSQRLAEFA 2866
Cdd:cd19537    133 AAYNGKLLPPVRREYLDSTAW-SRPASPEDLDFWSEYLS--GLPLLNLPRRT-SSKSYRG-TSRVFQLPGSLYRSLLQFS 207

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2183974163 2867 REQKVTLNTLVQAAWLILLQRFTGQDTVAFGATVSGRPAElrGIEEQIGLFINTLPV-VASPCPEQP-IGDWLQAVQ 2941
Cdd:cd19537    208 TSSGITLHQLALAAVALALQDLSDRTDIVLGAPYLNRTSE--EDMETVGLFLEPLPIrIRFPSSSDAsAADFLRAVR 282

beta-lac_NRPS

Condensation domain of nonribosomal peptide synthetases (NRPSs) similar to Nocardia uniformis ...

1129-1436

1.24e-15

Pssm-ID: 380469 [Multi-domain] Cd Length: 422 Bit Score: 82.36 E-value: 1.24e-15

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1129 PHSAAYNIPVALRLKGPLRRDALQGALDLLVQRHETLRTTFVEHDGA-PRQVIHPTLpiaieerRPPVAGEDLKGlvETE 1207
Cdd:cd19547     19 PDSDAYFNQNVLELVGGTDEDVLREAWRRVADRYEILRTGFTWRDRAePLQYVRDDL-------APPWALLDWSG--EDP 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1208 AHRPFDLQRgPLLRVLLLPLATDECVLV-LTL--------------HHIIADGWSMQVLVDELIRVYAALRHDQPPALAe 1272
Cdd:cd19547     90 DRRAELLER-LLADDRAAGLSLADCPLYrLTLvrlgggrhyllwshHHILLDGWCLSLIWGDVFRVYEELAHGREPQLS- 167

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1273 lPIQ-YADFAAWQR-QWMDGGERERqldYWVSRLG--GEQPLLELPSDRprpQQQSHrgrrigiPLPAELAEALRRL-AQ 1347
Cdd:cd19547    168 -PCRpYRDYVRWIRaRTAQSEESER---FWREYLRdlTPSPFSTAPADR---EGEFD-------TVVHEFPEQLTRLvNE 233

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1348 AEQG---TLFMLLLASFQALLHRYSGQNDIRVGVPIANR--NREETEGLIGFFVNTQVLRAELDGQLPFRELLRQVRQ-- 1420
Cdd:cd19547    234 AARGygvTTNAISQAAWSMLLALQTGARDVVHGLTIAGRppELEGSEHMVGIFINTIPLRIRLDPDQTVTGLLETIHRdl 313

                          330
                   ....*....|....*.
gi 2183974163 1421 AVVEAQGHqdLPFEQL 1436
Cdd:cd19547    314 ATTAAHGH--VPLAQI 327

PRK07769

long-chain-fatty-acid--CoA ligase; Validated

1563-2070

1.34e-15

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 181109 [Multi-domain] Cd Length: 631 Bit Score: 83.24 E-value: 1.34e-15

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1563 DFTPASCLHRLIERQAAERPRATAVVY--------GE-RALDYGELNLRANRLAHRLIELGvGPDVLVGLAAERSLEMIV 1633
Cdd:PRK07769    16 RFPPNTNLVRHVERWAKVRGDKLAYRFldfsterdGVaRDLTWSQFGARNRAVGARLQQVT-KPGDRVAILAPQNLDYLI 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1634 GLLAILKAGGAYVPL-DPRYP--SDRLGYMIEDSGIRLLLTQRAARER-------LPLGEGLPCLLLDAEHEWAGypESD 1703
Cdd:PRK07769    95 AFFGALYAGRIAVPLfDPAEPghVGRLHAVLDDCTPSAILTTTDSAEGvrkffraRPAKERPRVIAVDAVPDEVG--ATW 172

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1704 PQSAVGVDNLAYVIYTSGSTGKPKGTLLPH----GNVLRLFDAtrhwFGFSADD---AW-SLFHsyafDFSVWEIFGALL 1775
Cdd:PRK07769   173 VPPEANEDTIAYLQYTSGSTRIPAGVQITHlnlpTNVLQVIDA----LEGQEGDrgvSWlPFFH----DMGLITVLLPAL 244

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1776 HGGRLVIV-PYETSRSPEDFLRLLCRE---RVTVLNQTPS-AFKQLMQVACAGQEVPPLALRHV---VFGGEALEVQALR 1847
Cdd:PRK07769   245 LGHYITFMsPAAFVRRPGRWIRELARKpggTGGTFSAAPNfAFEHAAARGLPKDGEPPLDLSNVkglLNGSEPVSPASMR 324

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1848 PWFERF---GDRAPRLVNMYGITETTVHVTYRP---------LSLADLDGGAASPIGE----PIPDLS--------W-YL 1902
Cdd:PRK07769   325 KFNEAFapyGLPPTAIKPSYGMAEATLFVSTTPmdeeptviyVDRDELNAGRFVEVPAdapnAVAQVSagkvgvseWaVI 404

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1903 LDA-GLNPVPRGCIGELYVGGAGLARGYLNRPELSCTRF------VADPFSTTG----GRLYRTGDLARYrCDGVVEYVG 1971
Cdd:PRK07769   405 VDPeTASELPDGQIGEIWLHGNNIGTGYWGKPEETAATFqnilksRLSESHAEGapddALWVRTGDYGVY-FDGELYITG 483

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1972 RIDHQVKIRGFR-----IELGEIEARLLAQPGVAEAVVLP------------HEG----PGAT--QLVgyVVTQAAP--- 2025
Cdd:PRK07769   484 RVKDLVIIDGRNhypqdLEYTAQEATKALRTGYVAAFSVPanqlpqvvfddsHAGlkfdPEDTseQLV--IVAERAPgah 561

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....*....
gi 2183974163 2026 -SDPAALRDTLRQALKASlpeHMVPAHLLFLE---RLPLTANGKLDRRA 2070
Cdd:PRK07769   562 kLDPQPIADDIRAAIAVR---HGVTVRDVLLVpagSIPRTSSGKIARRA 607

beta-lac_NRPS

Condensation domain of nonribosomal peptide synthetases (NRPSs) similar to Nocardia uniformis ...

49-477

1.43e-15

Pssm-ID: 380469 [Multi-domain] Cd Length: 422 Bit Score: 81.97 E-value: 1.43e-15

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163   49 PLSYAQERQWFLWQMDPQSAAYNIPSALRLRGELDVEALSASLGAIVERHQSLRTVFVEDEQLDGFRqqvLASVDVPVPV 128
Cdd:cd19547      3 PLAPMQEGMLFRGLFWPDSDAYFNQNVLELVGGTDEDVLREAWRRVADRYEILRTGFTWRDRAEPLQ---YVRDDLAPPW 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  129 TL---AGDD-DAQAQI-RAFVESETQQPFDLRNGPLLRARLLRLAADDHVLTLTIHHVAADGWSMRVLVEELIALYGARR 203
Cdd:cd19547     80 ALldwSGEDpDRRAELlERLLADDRAAGLSLADCPLYRLTLVRLGGGRHYLLWSHHHILLDGWCLSLIWGDVFRVYEELA 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  204 QGIEATL-PDLPiqYADYAIWQRHWLEAG-ERERQLEYWMARLgGGQSVLELPTDRQrpalPSYRGARHElqLPQALGRQ 281
Cdd:cd19547    160 HGREPQLsPCRP--YRDYVRWIRARTAQSeESERFWREYLRDL-TPSPFSTAPADRE----GEFDTVVHE--FPEQLTRL 230

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  282 LQALAQREGTTLFMLLLASFQALLHRYSGQDEIRVGVPVANR--NRVETERLIGFFVNTQVLRADLDAQMPFLDLLQQTR 359
Cdd:cd19547    231 VNEAARGYGVTTNAISQAAWSMLLALQTGARDVVHGLTIAGRppELEGSEHMVGIFINTIPLRIRLDPDQTVTGLLETIH 310

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  360 --VAALGAQSHqdLPFEQLVEALQPERsLSHSPLFQAMYNHQNLGSagrqslaAQLPG--LSVEDLSWGAHS-AQFDLTL 434
Cdd:cd19547    311 rdLATTAAHGH--VPLAQIKSWASGER-LSGGRVFDNLVAFENYPE-------DNLPGddLSIQIIDLHAQEkTEYPIGL 380

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|...
gi 2183974163  435 DTYESEQgVHAEFTYATDLFEAATVERLARHWRNLLEAVVAEP 477
Cdd:cd19547    381 IVLPLQK-LAFHFNYDTTHFTRAQVDRFIEVFRLLTEQLCRRP 422

PLN02654

acetate-CoA ligase

1591-2071

1.91e-15

acetate-CoA ligase

Pssm-ID: 215353 [Multi-domain] Cd Length: 666 Bit Score: 83.02 E-value: 1.91e-15

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1591 ERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGYMIEDSGIRLLL 1670
Cdd:PLN02654   118 DASLTYSELLDRVCQLANYLKDVGVKKGDAVVIYLPMLMELPIAMLACARIGAVHSVVFAGFSAESLAQRIVDCKPKVVI 197

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1671 TQRAARERLPL---------------GEGLP---CLLLDAEH-------EW------------AGYPESDPQSAVGVDNL 1713
Cdd:PLN02654   198 TCNAVKRGPKTinlkdivdaaldesaKNGVSvgiCLTYENQLamkredtKWqegrdvwwqdvvPNYPTKCEVEWVDAEDP 277

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1714 AYVIYTSGSTGKPKGTLLPHGNVLrLFDATRHWFGF----------SADDAWSLFHSYAfdfsvweIFGALLHGGRLVIv 1783
Cdd:PLN02654   278 LFLLYTSGSTGKPKGVLHTTGGYM-VYTATTFKYAFdykptdvywcTADCGWITGHSYV-------TYGPMLNGATVLV- 348

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1784 pYETSRSPEDFLR---LLCRERVTVLNQTPSAFKQLMQvacAGQEvppLALRHV-----VFG--GEALEVQALRPWFERF 1853
Cdd:PLN02654   349 -FEGAPNYPDSGRcwdIVDKYKVTIFYTAPTLVRSLMR---DGDE---YVTRHSrkslrVLGsvGEPINPSAWRWFFNVV 421

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1854 GDRAPRLVNMYGITET-TVHVTYRPLSLADLDGGAASPIGEPIPdlswYLLDAGLNPVPRGCIGELYVGGA--GLARG-Y 1929
Cdd:PLN02654   422 GDSRCPISDTWWQTETgGFMITPLPGAWPQKPGSATFPFFGVQP----VIVDEKGKEIEGECSGYLCVKKSwpGAFRTlY 497

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1930 LNRPELSCTRFvaDPFSTtggrLYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVV--LPH 2007
Cdd:PLN02654   498 GDHERYETTYF--KPFAG----YYFSGDGCSRDKDGYYWLTGRVDDVINVSGHRIGTAEVESALVSHPQCAEAAVvgIEH 571

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2183974163 2008 EGPGATqLVGYVVTQAAPSDPAALRDTLRQALKASLPEHMVPAHLLFLERLPLTANGKLDRRAL 2071
Cdd:PLN02654   572 EVKGQG-IYAFVTLVEGVPYSEELRKSLILTVRNQIGAFAAPDKIHWAPGLPKTRSGKIMRRIL 634

PRK09192

fatty acyl-AMP ligase;

533-1023

2.19e-15

fatty acyl-AMP ligase;

Pssm-ID: 236403 [Multi-domain] Cd Length: 579 Bit Score: 82.36 E-value: 2.19e-15

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  533 EERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLdpQYPA---------DRLQYMI 603
Cdd:PRK09192    47 EEALPYQTLRARAEAGARRLLALGLKPGDRVALIAETDGDFVEAFFACQYAGLVPVPL--PLPMgfggresyiAQLRGML 124

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  604 DDSGLRLLLSQQSVLARLPQSDGLQSLLLDDLERLVHGYPAENPDLPEA-PDSLCYAIYTSGSTGQPKGVMVRHRALTNF 682
Cdd:PRK09192   125 ASAQPAAIITPDELLPWVNEATHGNPLLHVLSHAWFKALPEADVALPRPtPDDIAYLQYSSGSTRFPRGVIITHRALMAN 204

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  683 VCSIARQpGMLAR--DRLLSVTTFSFDIfGLE--LYVPLARGASM-LLASREQAQDPEALLDLVERQGVTVLQATPATWR 757
Cdd:PRK09192   205 LRAISHD-GLKVRpgDRCVSWLPFYHDM-GLVgfLLTPVATQLSVdYLPTRDFARRPLQWLDLISRNRGTISYSPPFGYE 282

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  758 mLC-------DSERVDLLRGCTLLCGGE--------ALAEDLAArmRGLSASTW-NLYGPTETTIW-------------- 807
Cdd:PRK09192   283 -LCarrvnskDLAELDLSCWRVAGIGADmirpdvlhQFAEAFAP--AGFDDKAFmPSYGLAEATLAvsfsplgsgivvee 359

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  808 ---------SARFRLGEEARPF-----LGGPLENTALYILDSEMNPCPPGVAGELLIGGDGLARGYHRRPGLTaerflpD 873
Cdd:PRK09192   360 vdrdrleyqGKAVAPGAETRRVrtfvnCGKALPGHEIEIRNEAGMPLPERVVGHICVRGPSLMSGYFRDEESQ------D 433

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  874 PFAADGsrLYRTGDLArYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVR--EAVVVAQPGVAGPTLVAyLVp 951
Cdd:PRK09192   434 VLAADG--WLDTGDLG-YLLDGYLYITGRAKDLIIINGRNIWPQDIEWIAEQEPELRsgDAAAFSIAQENGEKIVL-LV- 508

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2183974163  952 tEAALVDAEsARQQeLRSALKNSLLA-----VLPDyMVPAHmllleNLPLTPNGKINR-KALPLPDASAVRDAHVAPE 1023
Cdd:PRK09192   509 -QCRISDEE-RRGQ-LIHALAALVRSefgveAAVE-LVPPH-----SLPRTSSGKLSRaKAKKRYLSGAFASLDVAAS 577

PRK08279

long-chain-acyl-CoA synthetase; Validated

3085-3161

3.82e-15

long-chain-acyl-CoA synthetase; Validated

Pssm-ID: 236217 [Multi-domain] Cd Length: 600 Bit Score: 81.84 E-value: 3.82e-15

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2183974163 3085 RGVHRLFEEQVERTPTAPALAFGEERLDYAELNRRANRLAHALIERGIGADRLVGVAMERSIEMVVALMAILKAGGA 3161
Cdd:PRK08279    37 RSLGDVFEEAAARHPDRPALLFEDQSISYAELNARANRYAHWAAARGVGKGDVVALLMENRPEYLAAWLGLAKLGAV 113

PRK07656

long-chain-fatty-acid--CoA ligase; Validated

3090-3183

3.85e-15

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 236072 [Multi-domain] Cd Length: 513 Bit Score: 81.49 E-value: 3.85e-15

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3090 LFEEQVERTPTAPALAFGEERLDYAELNRRANRLAHALIERGIGA-DRlVGVAMERSIEMVVALMAILKAGGAYVPVDPE 3168
Cdd:PRK07656    10 LLARAARRFGDKEAYVFGDQRLTYAELNARVRRAAAALAALGIGKgDR-VAIWAPNSPHWVIAALGALKAGAVVVPLNTR 88

                           90
                   ....*....|....*
gi 2183974163 3169 YPEERQAYMLEDSGV 3183
Cdd:PRK07656    89 YTADEAAYILARGDA 103

C_PKS-NRPS

Condensation domain of hybrid polyketide synthetase/nonribosomal peptide synthetases (PKS ...

2206-2599

6.30e-15

Pssm-ID: 380471 [Multi-domain] Cd Length: 430 Bit Score: 80.00 E-value: 6.30e-15

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2206 DGTLLETALQALLAHHDALRLGFrlEDGTWRAEHRAVEAGEVLL----WQQSVADGQALEALAEQVQRS-LDLGSGPLLR 2280
Cdd:cd20483     37 DVNLLQKALSELVRRHEVLRTAY--FEGDDFGEQQVLDDPSFHLividLSEAADPEAALDQLVRNLRRQeLDIEEGEVIR 114

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2281 ALLATLGDGSQRLLLVIHHLVVDGVSWRILLEDLQTAYRQLQAGQAVA-LPAKT---SAFKAWAE-RLQAHARDGGLEge 2355
Cdd:cd20483    115 GWLVKLPDEEFALVLASHHIAWDRGSSKSIFEQFTALYDALRAGRDLAtVPPPPvqyIDFTLWHNaLLQSPLVQPLLD-- 192

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2356 rgYWLAQLEG---VSTELP---CDDREGAQSvrHVRSARTELTEEATRRL------LQEAPAAYrtqvndlLLTALARVI 2423
Cdd:cd20483    193 --FWKEKLEGipdASKLLPfakAERPPVKDY--ERSTVEATLDKELLARMkricaqHAVTPFMF-------LLAAFRAFL 261

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2424 GRWTGQADTLIQL----EGHGreelfediDLTRTVGWFTSLFPLRL--SPVAELGASIKRIKEQ-LRAIPHKGLGFGALr 2496
Cdd:cd20483    262 YRYTEDEDLTIGMvdgdRPHP--------DFDDLVGFFVNMLPIRCrmDCDMSFDDLLESTKTTcLEAYEHSAVPFDYI- 332

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2497 ylgsaedraaLAALPSPR---------ITFNYlgQFDGSFSADSSALFRPSADaagseRDSDAPLDNWLSLNGQVYA-GR 2566
Cdd:cd20483    333 ----------VDALDVPRstshfpigqIAVNY--QVHGKFPEYDTGDFKFTDY-----DHYDIPTACDIALEAEEDPdGG 395

                          410       420       430
                   ....*....|....*....|....*....|...
gi 2183974163 2567 LGIDWSFSAARFSEASILRLADAYRDELLALIE 2599
Cdd:cd20483    396 LDLRLEFSTTLYDSADMERFLDNFVTFLTSVIR 428

LC-FACS_euk

cd05927

Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS); The members of this family are ...

536-1007

7.27e-15

Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS); The members of this family are eukaryotic fatty acid CoA synthetases that activate fatty acids with chain lengths of 12 to 20. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions. Organisms tend to have multiple isoforms of LC-FACS genes with multiple splice variants. For example, nine genes are found in Arabidopsis and six genes are expressed in mammalian cells.

Pssm-ID: 341250 [Multi-domain] Cd Length: 545 Bit Score: 80.72 E-value: 7.27e-15

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  536 LSYAELNALANRLAWRLREEGV--GSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQYMIDDSGLRLLLS 613
Cdd:cd05927      6 ISYKEVAERADNIGSALRSLGGkpAPASFVGIYSINRPEWIISELACYAYSLVTVPLYDTLGPEAIEYILNHAEISIVFC 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  614 QqsvlarlpqsDGLQSLLLDDLERLVHGYPAENPdlPEAPDSLCYAIYTSGSTGQPKGVMVRHRALTNFVCSI----ARQ 689
Cdd:cd05927     86 D----------AGVKVYSLEEFEKLGKKNKVPPP--PPKPEDLATICYTSGTTGNPKGVMLTHGNIVSNVAGVfkilEIL 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  690 PGMLARDRLLSvttfsfdifglelYVPLA---------------------RGASMLLASREQAQDP-------------- 734
Cdd:cd05927    154 NKINPTDVYIS-------------YLPLAhifervvealflyhgakigfySGDIRLLLDDIKALKPtvfpgvprvlnriy 220

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  735 EALLDLVERQGV-------------------TVLQATPaTWRMLCDSERVDLLRGCT--LLCGGEALAEDLAARMRG-LS 792
Cdd:cd05927    221 DKIFNKVQAKGPlkrklfnfalnyklaelrsGVVRASP-FWDKLVFNKIKQALGGNVrlMLTGSAPLSPEVLEFLRVaLG 299

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  793 ASTWNLYGPTETTIWSARFRLGEEARPFLGGPLENtALYILDS--EMN-----PCPpgvAGELLIGGDGLARGYHRRPGL 865
Cdd:cd05927    300 CPVLEGYGQTECTAGATLTLPGDTSVGHVGGPLPC-AEVKLVDvpEMNydakdPNP---RGEVCIRGPNVFSGYYKDPEK 375

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  866 TAERFLPDPFaadgsrlYRTGDLARYRADGVIEYLGRIDHqvkIrgFRIELGE-IETRLLEQDSVReAVVVAQPGVAG-- 942
Cdd:cd05927    376 TAEALDEDGW-------LHTGDIGEWLPNGTLKIIDRKKN---I--FKLSQGEyVAPEKIENIYAR-SPFVAQIFVYGds 442

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  943 --PTLVAYLVPTEAALVD------------AESARQQELRSALKNSLLAV-----------LPDYMVPAHMLLLENLPLT 997
Cdd:cd05927    443 lkSFLVAIVVPDPDVLKEwaaskgggtgsfEELCKNPEVKKAILEDLVRLgkenglkgfeqVKAIHLEPEPFSVENGLLT 522

                          570
                   ....*....|
gi 2183974163  998 PNGKINRKAL 1007
Cdd:cd05927    523 PTFKLKRPQL 532

PRK06187

long-chain-fatty-acid--CoA ligase; Validated

3078-3182

8.42e-15

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 235730 [Multi-domain] Cd Length: 521 Bit Score: 80.23 E-value: 8.42e-15

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3078 AAEYPLQrgVHRLFEEQVERTPTAPALAFGEERLDYAELNRRANRLAHALIERGIGADRLVGVAMERSIEMVVALMAILK 3157
Cdd:PRK06187     1 MQDYPLT--IGRILRHGARKHPDKEAVYFDGRRTTYAELDERVNRLANALRALGVKKGDRVAVFDWNSHEYLEAYFAVPK 78

                           90       100
                   ....*....|....*....|....*
gi 2183974163 3158 AGGAYVPVDPEYPEERQAYMLEDSG 3182
Cdd:PRK06187    79 IGAVLHPINIRLKPEEIAYILNDAE 103

AMP-binding_C

pfam13193

AMP-binding enzyme C-terminal domain; This is a small domain that is found C terminal to ...

1988-2065

1.63e-14

AMP-binding enzyme C-terminal domain; This is a small domain that is found C terminal to pfam00501. It has a central beta sheet core that is flanked by alpha helices.

Pssm-ID: 463804 [Multi-domain] Cd Length: 76 Bit Score: 70.65 E-value: 1.63e-14

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1988 EIEARLLAQPGVAEAVV--LPHEGPGATqLVGYVVtqaAPSDPAALRDTLRQALKASLPEHMVPAHLLFLERLPLTANGK 2065
Cdd:pfam13193    1 EVESALVSHPAVAEAAVvgVPDELKGEA-PVAFVV---LKPGVELLEEELVAHVREELGPYAVPKEVVFVDELPKTRSGK 76

PRK05851

long-chain-fatty acid--ACP ligase MbtM;

1596-2068

1.70e-14

long-chain-fatty acid--ACP ligase MbtM;

Pssm-ID: 180289 [Multi-domain] Cd Length: 525 Bit Score: 79.42 E-value: 1.70e-14

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1596 YGELNLRANRLAHRLIELGvgPDVLVGLAAERSLEMIVGLLAILKAGGAYVPL-------DPRYPSDRLGYMIEDSGIRL 1668
Cdd:PRK05851    34 WPEVHGRAENVAARLLDRD--RPGAVGLVGEPTVELVAAIQGAWLAGAAVSILpgpvrgaDDGRWADATLTRFAGIGVRT 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1669 LLTQRAARERL-PLGEGLPCLLLDaehEWAGYPESDPQSAVGVDNLAYVIYTSGSTGKPKGTLLPHGNVLR----LFDAT 1743
Cdd:PRK05851   112 VLSHGSHLERLrAVDSSVTVHDLA---TAAHTNRSASLTPPDSGGPAVLQGTAGSTGTPRTAILSPGAVLSnlrgLNARV 188

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1744 RhwFGFSADDAWS---LFHSYAFDFsvweIFGALLHGGRLVIVPYET-SRSPEDFLRLLCRERVTVLNQTPSAFKQLMQV 1819
Cdd:PRK05851   189 G--LDAATDVGCSwlpLYHDMGLAF----LLTAALAGAPLWLAPTTAfSASPFRWLSWLSDSRATLTAAPNFAYNLIGKY 262

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1820 ACAGQEVPPLALRHVVFGGEALEVQALRPWFE---RFGDRAPRLVNMYGITETTVHVT-------YRPLSLADLDGGAA- 1888
Cdd:PRK05851   263 ARRVSDVDLGALRVALNGGEPVDCDGFERFATamaPFGFDAGAAAPSYGLAESTCAVTvpvpgigLRVDEVTTDDGSGAr 342

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1889 --SPIGEPIPDLSwYLLDAGLNPVPRGC--IGELYVGGAGLARGYLNRPELsctrfvaDPfsttgGRLYRTGDLArYRCD 1964
Cdd:PRK05851   343 rhAVLGNPIPGME-VRISPGDGAAGVAGreIGEIEIRGASMMSGYLGQAPI-------DP-----DDWFPTGDLG-YLVD 408

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1965 GVVEYVGRIDHQVKIRGFRIELGEIEaRLLAQ-PGVAE-AVVLPHEGPGATQLVGYVVTQAAPSDPAALRDTLRQALKAS 2042
Cdd:PRK05851   409 GGLVVCGRAKELITVAGRNIFPTEIE-RVAAQvRGVREgAVVAVGTGEGSARPGLVIAAEFRGPDEAGARSEVVQRVASE 487

                          490       500
                   ....*....|....*....|....*...
gi 2183974163 2043 LpeHMVPAHLLFLE--RLPLTANGKLDR 2068
Cdd:PRK05851   488 C--GVVPSDVVFVApgSLPRTSSGKLRR 513

PRK06814

acyl-[ACP]--phospholipid O-acyltransferase;

1711-2067

2.03e-14

acyl-[ACP]--phospholipid O-acyltransferase;

Pssm-ID: 235865 [Multi-domain] Cd Length: 1140 Bit Score: 80.01 E-value: 2.03e-14

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1711 DNLAYVIYTSGSTGKPKGTLLPHGNVL--RLFDATRhwFGFSADD----AWSLFHSyafdfsvweiFG-------ALLHG 1777
Cdd:PRK06814   793 DDPAVILFTSGSEGTPKGVVLSHRNLLanRAQVAAR--IDFSPEDkvfnALPVFHS----------FGltgglvlPLLSG 860

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1778 GRLVIVPyetsrSPEDFlRLLcRERVTVLNQT----PSAFkqLMQVACAGQEVPPLALRHVVFGGEALEVQALRPWFERF 1853
Cdd:PRK06814   861 VKVFLYP-----SPLHY-RII-PELIYDTNATilfgTDTF--LNGYARYAHPYDFRSLRYVFAGAEKVKEETRQTWMEKF 931

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1854 GdraPRLVNMYGITETTvhvtyrP-LSLADLDGGAASPIGEPIPdlswyLLDAGLNPVP---RGciGELYVGGAGLARGY 1929
Cdd:PRK06814   932 G---IRILEGYGVTETA------PvIALNTPMHNKAGTVGRLLP-----GIEYRLEPVPgidEG--GRLFVRGPNVMLGY 995

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1930 LnRPElscTRFVADPFSttgGRLYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEArlLAQ---PGVAEAVV-L 2005
Cdd:PRK06814   996 L-RAE---NPGVLEPPA---DGWYDTGDIVTIDEEGFITIKGRAKRFAKIAGEMISLAAVEE--LAAelwPDALHAAVsI 1066

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2183974163 2006 PHEGPGaTQLVgyVVTQAAPSDPAALrdtLRQALKASLPEHMVPAHLLFLERLPLTANGKLD 2067
Cdd:PRK06814  1067 PDARKG-ERII--LLTTASDATRAAF---LAHAKAAGASELMVPAEIITIDEIPLLGTGKID 1122

PRK12582

acyl-CoA synthetase; Provisional

485-891

2.31e-14

acyl-CoA synthetase; Provisional

Pssm-ID: 237144 [Multi-domain] Cd Length: 624 Bit Score: 79.32 E-value: 2.31e-14

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  485 PLLDAEERA--TLLQRSRLPASEYPagQGVHRLFEAQAGLTPDAPALLFGE------ERLSYAELNALANRLAWRLREEG 556
Cdd:PRK12582    24 PDISVERRAdgSIVIKSRHPLGPYP--RSIPHLLAKWAAEAPDRPWLAQREpghgqwRKVTYGEAKRAVDALAQALLDLG 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  557 VGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPA-----DRLQYMIDDSGLRLLLSQQSVlarlPQSDGLQSLL 631
Cdd:PRK12582   102 LDPGRPVMILSGNSIEHALMTLAAMQAGVPAAPVSPAYSLmshdhAKLKHLFDLVKPRVVFAQSGA----PFARALAALD 177

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  632 LDDLERLVHGYPAE-NPDLPEA-------------------PDSLCYAIYTSGSTGQPKGVMVRHRALtnfvCS-IARQP 690
Cdd:PRK12582   178 LLDVTVVHVTGPGEgIASIAFAdlaatpptaavaaaiaaitPDTVAKYLFTSGSTGMPKAVINTQRMM----CAnIAMQE 253

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  691 GMLARDRLLSVTTfSFD------IFG--LELYVPLARGASMLL-ASREQAQDPEALLDLVERQGVTVLQATPATWRMLCD 761
Cdd:PRK12582   254 QLRPREPDPPPPV-SLDwmpwnhTMGgnANFNGLLWGGGTLYIdDGKPLPGMFEETIRNLREISPTVYGNVPAGYAMLAE 332

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  762 S-ERVDLLRGC------TLLCGGEALAEDLAARMRGLSAST-------WNLYGPTET------TIWSARfRLGEearpfL 821
Cdd:PRK12582   333 AmEKDDALRRSffknlrLMAYGGATLSDDLYERMQALAVRTtghripfYTGYGATETaptttgTHWDTE-RVGL-----I 406

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  822 GGPLENTALYILdsemnpcPPGVAGELLIGGDGLARGYHRRPGLTAERFlpdpfaaDGSRLYRTGDLARY 891
Cdd:PRK12582   407 GLPLPGVELKLA-------PVGDKYEVRVKGPNVTPGYHKDPELTAAAF-------DEEGFYRLGDAARF 462

E-C_NRPS

Dual Epimerization/Condensation (E/C) domains of nonribosomal peptide synthetases (NRPSs); ...

63-421

2.56e-14

Pssm-ID: 380466 [Multi-domain] Cd Length: 413 Bit Score: 78.25 E-value: 2.56e-14

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163   63 MDPQSAAYNIPSALRLRGELDVEALSASLGAIVERHQSLRTVFVEdEQLDGFRQQVLASVDVPV-PVTLAGDDDAQAQIR 141
Cdd:cd19544     17 LAEEGDPYLLRSLLAFDSRARLDAFLAALQQVIDRHDILRTAILW-EGLSEPVQVVWRQAELPVeELTLDPGDDALAQLR 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  142 AFVESEtQQPFDLRNGP-LLRARLLRLAADDHVLTLTIHHVAADGWSMRVLVEELIALygarRQGIEATLPDlPIQYADY 220
Cdd:cd19544     96 ARFDPR-RYRLDLRQAPlLRAHVAEDPANGRWLLLLLFHHLISDHTSLELLLEEIQAI----LAGRAAALPP-PVPYRNF 169

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  221 AIWQRHwleAGERERQLEYWMARLGGgqsVLElptdrqrPALP---------SYRGARHELQLPQALGRQLQALAQREGT 291
Cdd:cd19544    170 VAQARL---GASQAEHEAFFREMLGD---VDE-------PTAPfglldvqgdGSDITEARLALDAELAQRLRAQARRLGV 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  292 TlfmllLASfqaLLH--------RYSGQDEIRVGVPVANRNR--VETERLIGFFVNTQVLRADLDaQMPFLDLLQQT--R 359
Cdd:cd19544    237 S-----PAS---LFHlawalvlaRCSGRDDVVFGTVLSGRMQggAGADRALGMFINTLPLRVRLG-GRSVREAVRQThaR 307

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  360 VAALgaqshqdLPFEQ--LVEAlQPERSLSHS-PLFQAMYNHQNLGSAGRQSLAAQLPG---------------LSVEDL 421
Cdd:cd19544    308 LAEL-------LRHEHasLALA-QRCSGVPAPtPLFSALLNYRHSAAAAAAAALAAWEGiellggeertnypltLSVDDL 379

AcpP

COG0236

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the ...

1021-1095

2.91e-14

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis

Pssm-ID: 440006 [Multi-domain] Cd Length: 80 Bit Score: 70.27 E-value: 2.91e-14

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2183974163 1021 APEGELERAMAAIWSEVLKL--GHIGRDDNFF-ELGGHSLLVTQVVSRVRRRLDLQVPLRTLFEHSTLRAYAQAVAQL 1095
Cdd:COG0236      1 MPREELEERLAEIIAEVLGVdpEEITPDDSFFeDLGLDSLDAVELIAALEEEFGIELPDTELFEYPTVADLADYLEEK 78

LC_FACS_euk1

cd17639

Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS), including fungal proteins; The ...

1596-2040

3.12e-14

Pssm-ID: 341294 [Multi-domain] Cd Length: 507 Bit Score: 78.41 E-value: 3.12e-14

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1596 YGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGgayVPLDPRYpsDRLGymieDSGIRLLLTQRAA 1675
Cdd:cd17639      8 YAEVWERVLNFGRGLVELGLKPGDKVAIFAETRAEWLITALGCWSQN---IPIVTVY--ATLG----EDALIHSLNETEC 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1676 RerlplgeglpCLLLDAEHewagypesdpqsavgvDNLAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRHW-FGFSADDA 1754
Cdd:cd17639     79 S----------AIFTDGKP----------------DDLACIMYTSGSTGNPKGVMLTHGNLVAGIAGLGDRvPELLGPDD 132

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1755 WSLfhSY-----AFDFSVWEIFgaLLHGGRL------VIVPYETSRSPEDFL-----------RLLCRERVTVLNQTPSA 1812
Cdd:cd17639    133 RYL--AYlplahIFELAAENVC--LYRGGTIgygsprTLTDKSKRGCKGDLTefkptlmvgvpAIWDTIRKGVLAKLNPM 208

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1813 -------FKQLMQVACAGQEVPPLA--LRHVVF----------------GGEALEVQALRpWFERFGdrAPrLVNMYGIT 1867
Cdd:cd17639    209 gglkrtlFWTAYQSKLKALKEGPGTplLDELVFkkvraalggrlrymlsGGAPLSADTQE-FLNIVL--CP-VIQGYGLT 284

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1868 ETTVHVTYrpLSLADLDGGAaspIGEPIPDLSWYLLD---AGL---NPVPRGcigELYVGGAGLARGYLNRPELSCTRFv 1941
Cdd:cd17639    285 ETCAGGTV--QDPGDLETGR---VGPPLPCCEIKLVDweeGGYstdKPPPRG---EILIRGPNVFKGYYKNPEKTKEAF- 355

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1942 adpfstTGGRLYRTGDLARYRCDGVVEYVGRIDHQVKIR-GFRIELGEIEARLLAQPGVAEAVVLPHegPGATQLVGYVV 2020
Cdd:cd17639    356 ------DGDGWFHTGDIGEFHPDGTLKIIDRKKDLVKLQnGEYIALEKLESIYRSNPLVNNICVYAD--PDKSYPVAIVV 427

                          490       500
                   ....*....|....*....|
gi 2183974163 2021 TqaapsDPAALRDTLRQALK 2040
Cdd:cd17639    428 P-----NEKHLTKLAEKHGV 442

PRK08974

long-chain-fatty-acid--CoA ligase FadD;

575-1007

5.10e-14

long-chain-fatty-acid--CoA ligase FadD;

Pssm-ID: 236359 [Multi-domain] Cd Length: 560 Bit Score: 78.17 E-value: 5.10e-14

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  575 VALLAVLKAGGAYVPLDPQYPADRLQYMIDDSG-------------LRLLLSQQSV----LAR----LPQSDG-LQSLLL 632
Cdd:PRK08974    89 IALFGILRAGMIVVNVNPLYTPRELEHQLNDSGakaivivsnfahtLEKVVFKTPVkhviLTRmgdqLSTAKGtLVNFVV 168

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  633 DDLERLVHGYpaenpDLPEA---------------------PDSLCYAIYTSGSTGQPKGVMVRHR-ALTN-FVCSIARQ 689
Cdd:PRK08974   169 KYIKRLVPKY-----HLPDAisfrsalhkgrrmqyvkpelvPEDLAFLQYTGGTTGVAKGAMLTHRnMLANlEQAKAAYG 243

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  690 PgMLARDRLLSVTTFS-FDIFGLE----LYVPLarGASMLLASreQAQDPEALLDLVERQGVTVLQATPATWRMLCDSER 764
Cdd:PRK08974   244 P-LLHPGKELVVTALPlYHIFALTvnclLFIEL--GGQNLLIT--NPRDIPGFVKELKKYPFTAITGVNTLFNALLNNEE 318

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  765 VDLLRGCTL---LCGGEALAEDLAARMRGLSAStwNL---YGPTETTIWSArfrlgeeARPF--------LGGPLENTAL 830
Cdd:PRK08974   319 FQELDFSSLklsVGGGMAVQQAVAERWVKLTGQ--YLlegYGLTECSPLVS-------VNPYdldyysgsIGLPVPSTEI 389

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  831 YILDSEMNPCPPGVAGELLIGGDGLARGYHRRPGLTAErFLPDPFAAdgsrlyrTGDLARYRADGVIEYLGRIDHQVKIR 910
Cdd:PRK08974   390 KLVDDDGNEVPPGEPGELWVKGPQVMLGYWQRPEATDE-VIKDGWLA-------TGDIAVMDEEGFLRIVDRKKDMILVS 461

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  911 GFRIELGEIETRLLEQDSVREAVVVAQP-GVAGPTLVAYLVPTEAALVdaesarQQELRSALKNSLLAvlpdYMVPAHML 989
Cdd:PRK08974   462 GFNVYPNEIEDVVMLHPKVLEVAAVGVPsEVSGEAVKIFVVKKDPSLT------EEELITHCRRHLTG----YKVPKLVE 531

                          490
                   ....*....|....*...
gi 2183974163  990 LLENLPLTPNGKINRKAL 1007
Cdd:PRK08974   532 FRDELPKSNVGKILRREL 549

PrpE

cd05967

Propionyl-CoA synthetase (PrpE); EC 6.2.1.17: propanoate:CoA ligase (AMP-forming) or ...

523-1007

5.41e-14

Pssm-ID: 341271 [Multi-domain] Cd Length: 617 Bit Score: 78.13 E-value: 5.41e-14

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  523 TPDAPALLF-----GEER-LSYAELNALANRLAWRLREEGVGSDVLVGIALergvPMV----VALLAVLKAGGAYVPLDP 592
Cdd:cd05967     64 RGDQIALIYdspvtGTERtYTYAELLDEVSRLAGVLRKLGVVKGDRVIIYM----PMIpeaaIAMLACARIGAIHSVVFG 139

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  593 QYPADRLQYMIDDSGLRLLLSQQSVLA---------------RLPQSDGLQSLLLD---------------DLERLVHGY 642
Cdd:cd05967    140 GFAAKELASRIDDAKPKLIVTASCGIEpgkvvpykplldkalELSGHKPHHVLVLNrpqvpadltkpgrdlDWSELLAKA 219

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  643 PAENPDLPEAPDSLcYAIYTSGSTGQPKGVmVRHRA--LTNFVCSIARQPGMLARDRLLS------VTTFSFDIFGlely 714
Cdd:cd05967    220 EPVDCVPVAATDPL-YILYTSGTTGKPKGV-VRDNGghAVALNWSMRNIYGIKPGDVWWAasdvgwVVGHSYIVYG---- 293

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  715 vPLARGASMLL--ASREQAQDPEALLDLVERQGVTVLQATPATWRML-CDSERVDLLRGC------TLLCGGEALAEDLA 785
Cdd:cd05967    294 -PLLHGATTVLyeGKPVGTPDPGAFWRVIEKYQVNALFTAPTAIRAIrKEDPDGKYIKKYdlsslrTLFLAGERLDPPTL 372

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  786 ARMRG-LSASTWNLYGPTETTiWS-ARFRLGEEARPFLGG----PLENTALYILDSEMNPCPPGVAGELLIGGD---GLA 856
Cdd:cd05967    373 EWAENtLGVPVIDHWWQTETG-WPiTANPVGLEPLPIKAGspgkPVPGYQVQVLDEDGEPVGPNELGNIVIKLPlppGCL 451

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  857 RGYHRRPgltaERFLpDPFAADGSRLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVA 936
Cdd:cd05967    452 LTLWKND----ERFK-KLYLSKFPGYYDTGDAGYKDEDGYLFIMGRTDDVINVAGHRLSTGEMEESVLSHPAVAECAVVG 526

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2183974163  937 QP-GVAGPTLVAYLVPTEAALVDAESArQQELRSALKNSLLAVlpdyMVPAHMLLLENLPLTPNGKINRKAL 1007
Cdd:cd05967    527 VRdELKGQVPLGLVVLKEGVKITAEEL-EKELVALVREQIGPV----AAFRLVIFVKRLPKTRSGKILRRTL 593

AcpP

COG0236

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the ...

2085-2152

5.71e-14

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis

Pssm-ID: 440006 [Multi-domain] Cd Length: 80 Bit Score: 69.50 E-value: 5.71e-14

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2183974163 2085 APRSELEQRLAAIWADVLKL--GRVGLDDNFF-ELGGDSIISIQVVSRARQA-GIRLAPRDLFLHQTIRGLA 2152
Cdd:COG0236      1 MPREELEERLAEIIAEVLGVdpEEITPDDSFFeDLGLDSLDAVELIAALEEEfGIELPDTELFEYPTVADLA 72

PRK08162

acyl-CoA synthetase; Validated

524-1007

7.13e-14

acyl-CoA synthetase; Validated

Pssm-ID: 236169 [Multi-domain] Cd Length: 545 Bit Score: 77.68 E-value: 7.13e-14

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  524 PDAPALLFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQYMI 603
Cdd:PRK08162    32 PDRPAVIHGDRRRTWAETYARCRRLASALARRGIGRGDTVAVLLPNIPAMVEAHFGVPMAGAVLNTLNTRLDAASIAFML 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  604 DDSGLRLLLSQQ--SVLAR--LPQSDGLQSLLLD---------------DLERLV-HGypaeNPDLP-EAPDSLCYAI-- 660
Cdd:PRK08162   112 RHGEAKVLIVDTefAEVAReaLALLPGPKPLVIDvddpeypggrfigalDYEAFLaSG----DPDFAwTLPADEWDAIal 187

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  661 -YTSGSTGQPKGVMVRHR-----ALTNFV-CSIARQPGMlardrLLSVTTFSFDIFGLELYVPLARGASMLLasreQAQD 733
Cdd:PRK08162   188 nYTSGTTGNPKGVVYHHRgaylnALSNILaWGMPKHPVY-----LWTLPMFHCNGWCFPWTVAARAGTNVCL----RKVD 258

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  734 PEALLDLVERQGVTVLQATPATWRMLC---DSERVDLLRGCTLLCGGEALAEDLAARMRGLSASTWNLYGPTET----TI 806
Cdd:PRK08162   259 PKLIFDLIREHGVTHYCGAPIVLSALInapAEWRAGIDHPVHAMVAGAAPPAAVIAKMEEIGFDLTHVYGLTETygpaTV 338

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  807 ------WSArfrLGEEARPFLGG------PLENtALYILDSE-MNPCPPG--VAGELLIGGDGLARGYHRRPGLTAERFl 871
Cdd:PRK08162   339 cawqpeWDA---LPLDERAQLKArqgvryPLQE-GVTVLDPDtMQPVPADgeTIGEIMFRGNIVMKGYLKNPKATEEAF- 413

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  872 pdpfaADGsrLYRTGDLARYRADGVIeylgridhQVKIR--------GFRIELGEIETRLLEQDSVREAVVVAQPGVA-G 942
Cdd:PRK08162   414 -----AGG--WFHTGDLAVLHPDGYI--------KIKDRskdiiisgGENISSIEVEDVLYRHPAVLVAAVVAKPDPKwG 478

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2183974163  943 PTLVAYLvpteaALVDAESARQQELRSALKnsllAVLPDYMVPAHMLLLEnLPLTPNGKINRKAL 1007
Cdd:PRK08162   479 EVPCAFV-----ELKDGASATEEEIIAHCR----EHLAGFKVPKAVVFGE-LPKTSTGKIQKFVL 533

PRK12582

acyl-CoA synthetase; Provisional

1547-1961

1.21e-13

acyl-CoA synthetase; Provisional

Pssm-ID: 237144 [Multi-domain] Cd Length: 624 Bit Score: 77.01 E-value: 1.21e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1547 EAEARAD--LLQWNPGPQDFTPASCLHRLIER--QAAERP---RATAVVYGERALDYGELNLRANRLAHRLIELGVGPDV 1619
Cdd:PRK12582    27 SVERRADgsIVIKSRHPLGPYPRSIPHLLAKWaaEAPDRPwlaQREPGHGQWRKVTYGEAKRAVDALAQALLDLGLDPGR 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1620 LVGLAAERSLEMIVGLLAILKAGGAYVPLDPRY---PSD--RLGYMIEDSGIRLLLTQRAAR-ER--------------- 1678
Cdd:PRK12582   107 PVMILSGNSIEHALMTLAAMQAGVPAAPVSPAYslmSHDhaKLKHLFDLVKPRVVFAQSGAPfARalaaldlldvtvvhv 186

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1679 LPLGEGLPCLLLDaehEWAGYPESD----PQSAVGVDNLAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRHWFGFSADDA 1754
Cdd:PRK12582   187 TGPGEGIASIAFA---DLAATPPTAavaaAIAAITPDTVAKYLFTSGSTGMPKAVINTQRMMCANIAMQEQLRPREPDPP 263

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1755 wslfHSYAFDFSVWE-------IFGALL-HGGRLVI-----VP---YETSR-----SPedflrllcrervTVLNQTPSAF 1813
Cdd:PRK12582   264 ----PPVSLDWMPWNhtmggnaNFNGLLwGGGTLYIddgkpLPgmfEETIRnlreiSP------------TVYGNVPAGY 327

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1814 KQLmqvACAGQEVPPLA------LRHVVFGGEAL------EVQALRpwFERFGDRAPrLVNMYGITET-----TVH-VTY 1875
Cdd:PRK12582   328 AML---AEAMEKDDALRrsffknLRLMAYGGATLsddlyeRMQALA--VRTTGHRIP-FYTGYGATETaptttGTHwDTE 401

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1876 RPlsladldggaaSPIGEPIPDLSwylldagLNPVPRGCIGELYVGGAGLARGYLNRPELSctrfvADPFSTTGgrLYRT 1955
Cdd:PRK12582   402 RV-----------GLIGLPLPGVE-------LKLAPVGDKYEVRVKGPNVTPGYHKDPELT-----AAAFDEEG--FYRL 456


                   ....*.
gi 2183974163 1956 GDLARY 1961
Cdd:PRK12582   457 GDAARF 462

PRK05620

long-chain fatty-acid--CoA ligase;

532-1027

1.85e-13

long-chain fatty-acid--CoA ligase;

Pssm-ID: 180167 [Multi-domain] Cd Length: 576 Bit Score: 76.36 E-value: 1.85e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  532 GEERLSYAELNALANRLAWRLREE-GVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQYMIDDSGLRL 610
Cdd:PRK05620    35 EQEQTTFAAIGARAAALAHALHDElGITGDQRVGSMMYNCAEHLEVLFAVACMGAVFNPLNKQLMNDQIVHIINHAEDEV 114

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  611 LLSQQSVLAR----LPQSDGLQSLLL-------------------DDLERLVHGYPAEN--PDLPE-APDSLCYaiyTSG 664
Cdd:PRK05620   115 IVADPRLAEQlgeiLKECPCVRAVVFigpsdadsaaahmpegikvYSYEALLDGRSTVYdwPELDEtTAAAICY---STG 191

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  665 STGQPKGVMVRHRALtnFVCSIarqpGMLARDRlLSVTTFSFDIFGLELY------VPLA---RGASMLLASREqaQDPE 735
Cdd:PRK05620   192 TTGAPKGVVYSHRSL--YLQSL----SLRTTDS-LAVTHGESFLCCVPIYhvlswgVPLAafmSGTPLVFPGPD--LSAP 262

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  736 ALLDLVERQGVTVLQATPATWRMLC------DSERVDLLrgcTLLCGGEALAEDLaarmrglsASTW---------NLYG 800
Cdd:PRK05620   263 TLAKIIATAMPRVAHGVPTLWIQLMvhylknPPERMSLQ---EIYVGGSAVPPIL--------IKAWeerygvdvvHVWG 331

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  801 PTETTiwsarfRLGEEARPFLGGPLENTALY---------------ILDSEMNPCPPGVAGELLIGGDGLARGYHRRP-- 863
Cdd:PRK05620   332 MTETS------PVGTVARPPSGVSGEARWAYrvsqgrfpasleyriVNDGQVMESTDRNEGEIQVRGNWVTASYYHSPte 405

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  864 --GLTAERF-------LPDPFAADGsrLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVV 934
Cdd:PRK05620   406 egGGAASTFrgedvedANDRFTADG--WLRTGDVGSVTRDGFLTIHDRARDVIRSGGEWIYSAQLENYIMAAPEVVECAV 483

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  935 VaqpGVAGPTLVAYlvPTEAALVDAESARQQELRSALKNSLLAVLPDYMVPAHMLLLENLPLTPNGKINRKALplpdasa 1014
Cdd:PRK05620   484 I---GYPDDKWGER--PLAVTVLAPGIEPTRETAERLRDQLRDRLPNWMLPEYWTFVDEIDKTSVGKFDKKDL------- 551

                          570
                   ....*....|...
gi 2183974163 1015 vrDAHVApEGELE 1027
Cdd:PRK05620   552 --RQHLA-DGDFE 561

AACS

cd05943

Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); AACS is a cytosolic ligase that ...

523-1018

2.12e-13

Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); AACS is a cytosolic ligase that specifically activates acetoacetate to its coenzyme A ester by a two-step reaction. Acetoacetate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is the first step of the mevalonate pathway of isoprenoid biosynthesis via isopentenyl diphosphate. Isoprenoids are a large class of compounds found in all living organisms. AACS is widely distributed in bacteria, archaea and eukaryotes. In bacteria, AACS is known to exhibit an important role in the metabolism of poly-b-hydroxybutyrate, an intracellular reserve of organic carbon and chemical energy by some microorganisms. In mammals, AACS influences the rate of ketone body utilization for the formation of physiologically important fatty acids and cholesterol.

Pssm-ID: 341265 [Multi-domain] Cd Length: 629 Bit Score: 76.16 E-value: 2.12e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  523 TPDAPALLFGEE----RLSYAELNALANRLAWRLREEGVG-SDVLVGIaLERGVPMVVALLAVLKAGGAYVPLDPQYPA- 596
Cdd:cd05943     82 ADDPAAIYAAEDgertEVTWAELRRRVARLAAALRALGVKpGDRVAGY-LPNIPEAVVAMLATASIGAIWSSCSPDFGVp 160

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  597 ---DRLQyMIDDsglRLLLSQQSVL---ARLPQSDGLQSLL--LDDLERLVH---GYPAENPDLPEAPDSLCYA------ 659
Cdd:cd05943    161 gvlDRFG-QIEP---KVLFAVDAYTyngKRHDVREKVAELVkgLPSLLAVVVvpyTVAAGQPDLSKIAKALTLEdflatg 236

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  660 ------------------IYTSGSTGQPK-------GVMVRHRALTNFVCSIarQPGmlarDRLLSVTT-----FSFDIF 709
Cdd:cd05943    237 aagelefeplpfdhplyiLYSSGTTGLPKcivhgagGTLLQHLKEHILHCDL--RPG----DRLFYYTTcgwmmWNWLVS 310

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  710 GlelyvpLARGASMLLASREQ-AQDPEALLDLVERQGVTVLqATPATWRMLCD------SERVDLLRGCTLLCGGEALA- 781
Cdd:cd05943    311 G------LAVGATIVLYDGSPfYPDTNALWDLADEEGITVF-GTSAKYLDALEkaglkpAETHDLSSLRTILSTGSPLKp 383

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  782 -------EDLAARMRGLSAStwnlyGPTEttIWSArFRLGEEARPFLGGPLE----NTALYILDSEMNPCpPGVAGELLI 850
Cdd:cd05943    384 esfdyvyDHIKPDVLLASIS-----GGTD--IISC-FVGGNPLLPVYRGEIQcrglGMAVEAFDEEGKPV-WGEKGELVC 454

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  851 ggdglARGYHRRPgltaERFLPDPfaaDGSR-----------LYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEI 919
Cdd:cd05943    455 -----TKPFPSMP----VGFWNDP---DGSRyraayfakypgVWAHGDWIEITPRGGVVILGRSDGTLNPGGVRIGTAEI 522

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  920 ETRLLEQDSVREAVVVAQPGVAGPT-LVAYLVPTEAALVDAEsaRQQELRSALKNSLLAvlpdYMVPAHMLLLENLPLTP 998
Cdd:cd05943    523 YRVVEKIPEVEDSLVVGQEWKDGDErVILFVKLREGVELDDE--LRKRIRSTIRSALSP----RHVPAKIIAVPDIPRTL 596

                          570       580
                   ....*....|....*....|....*..
gi 2183974163  999 NGKIN----RKAL---PLPDASAVRDA 1018
Cdd:cd05943    597 SGKKVevavKKIIagrPVKNAGALANP 623

prpE

PRK10524

propionyl-CoA synthetase; Provisional

1571-2073

2.65e-13

propionyl-CoA synthetase; Provisional

Pssm-ID: 182517 [Multi-domain] Cd Length: 629 Bit Score: 76.14 E-value: 2.65e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1571 HRLIERQAAERPRATAVVY------GERALDYGELNLRANRLAHRLIELGV--GPDVLVGLA--AERSLEMivglLAILK 1640
Cdd:PRK10524    56 HNAVDRHLAKRPEQLALIAvstetdEERTYTFRQLHDEVNRMAAMLRSLGVqrGDRVLIYMPmiAEAAFAM----LACAR 131

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1641 AGGAYVPLDPRYPSDRLGYMIEDSGIRLLLTQRA-AR------------ERLPLGEGLP--CLLLD-----------AEH 1694
Cdd:PRK10524   132 IGAIHSVVFGGFASHSLAARIDDAKPVLIVSADAgSRggkvvpykplldEAIALAQHKPrhVLLVDrglapmarvagRDV 211

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1695 EWAGYPESDPQSAVGVDNL-----AYVIYTSGSTGKPKGtllphgnVLR--------LFDATRHWFG-------FSADD- 1753
Cdd:PRK10524   212 DYATLRAQHLGARVPVEWLesnepSYILYTSGTTGKPKG-------VQRdtggyavaLATSMDTIFGgkagetfFCASDi 284

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1754 AWSLFHSYAfdfsvweIFGALLHGgrLVIVPYE---TSRSPEDFLRLLCRERVTVLNQTPSAFKQLMQvacagQEVPPL- 1829
Cdd:PRK10524   285 GWVVGHSYI-------VYAPLLAG--MATIMYEglpTRPDAGIWWRIVEKYKVNRMFSAPTAIRVLKK-----QDPALLr 350

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1830 -----ALRHVVFGGEALE-------VQAL-RP-----------W-----FERFGDRAPRL----VNMYG-----ITETTv 1871
Cdd:PRK10524   351 khdlsSLRALFLAGEPLDeptaswiSEALgVPvidnywqtetgWpilaiARGVEDRPTRLgspgVPMYGynvklLNEVT- 429

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1872 hvtyrplsladldggaaspiGEPI-PDLSWYLLDAGlnPVPRGCIGELYVGGAglargylnrpelsctRFVADPFSTTGG 1950
Cdd:PRK10524   430 --------------------GEPCgPNEKGVLVIEG--PLPPGCMQTVWGDDD---------------RFVKTYWSLFGR 472

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1951 RLYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAE-AVVlphegpG-ATQLVGYV-VTQAAPSD 2027
Cdd:PRK10524   473 QVYSTFDWGIRDADGYYFILGRTDDVINVAGHRLGTREIEESISSHPAVAEvAVV------GvKDALKGQVaVAFVVPKD 546

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2183974163 2028 PAALRDT-LRQALKASLPEHMV--------PAHLLFLERLPLTANGKLDRRALPA 2073
Cdd:PRK10524   547 SDSLADReARLALEKEIMALVDsqlgavarPARVWFVSALPKTRSGKLLRRAIQA 601

PLN03102

acyl-activating enzyme; Provisional

661-1037

3.90e-13

acyl-activating enzyme; Provisional

Pssm-ID: 215576 [Multi-domain] Cd Length: 579 Bit Score: 75.44 E-value: 3.90e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  661 YTSGSTGQPKGVMVRHRA--LTNFVCSIARQPGMLARdRLLSVTTFSFDIFGLELYVPlARGASMLLASREQAqdPEALL 738
Cdd:PLN03102   193 YTSGTTADPKGVVISHRGayLSTLSAIIGWEMGTCPV-YLWTLPMFHCNGWTFTWGTA-ARGGTSVCMRHVTA--PEIYK 268

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  739 DlVERQGVTVLQATPATWRMLCDSERVDLLRGCT---LLCGGEALAEDLAARMRGLSASTWNLYGPTETT------IWSA 809
Cdd:PLN03102   269 N-IEMHNVTHMCCVPTVFNILLKGNSLDLSPRSGpvhVLTGGSPPPAALVKKVQRLGFQVMHAYGLTEATgpvlfcEWQD 347

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  810 RF-RLGEEARPFLGGP--LENTALYILD------SEMNPCPPGVAGELLIGGDGLARGYHRRPGLTAERFlpdpfaadGS 880
Cdd:PLN03102   348 EWnRLPENQQMELKARqgVSILGLADVDvknketQESVPRDGKTMGEIVIKGSSIMKGYLKNPKATSEAF--------KH 419

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  881 RLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQPG-VAGPTLVAYLV-----PTEA 954
Cdd:PLN03102   420 GWLNTGDVGVIHPDGHVEIKDRSKDIIISGGENISSVEVENVLYKYPKVLETAVVAMPHpTWGETPCAFVVlekgeTTKE 499

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  955 ALVDAESARQQELRSALKNSLlavlPDYMVPAHMLLLENLPLTPNGKINRKAL-PLPDASAVRDAHVAPEGELERAMAAI 1033
Cdd:PLN03102   500 DRVDKLVTRERDLIEYCRENL----PHFMCPRKVVFLQELPKNGNGKILKPKLrDIAKGLVVEDEDNVIKKVHQRPVEHF 575


                   ....
gi 2183974163 1034 WSEV 1037
Cdd:PLN03102   576 SSRL 579

PRK05857

fatty acid--CoA ligase;

499-1007

5.22e-13

fatty acid--CoA ligase;

Pssm-ID: 180293 [Multi-domain] Cd Length: 540 Bit Score: 74.66 E-value: 5.22e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  499 SRLPASEypagqgVHRLFEaQAGLTPDAPALLF--GEERLSYAELNALANRLAWRLREEGV--GSDVLVgiALERGVPMV 574
Cdd:PRK05857    10 PQLPSTV------LDRVFE-QARQQPEAIALRRcdGTSALRYRELVAEVGGLAADLRAQSVsrGSRVLV--ISDNGPETY 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  575 VALLAVLKAGGAYVPLDPQYPA---DRLQYMIDDSGlrLLLSQQSVLARLPQSDGLQSL------LLDDLERLVHG---- 641
Cdd:PRK05857    81 LSVLACAKLGAIAVMADGNLPIaaiERFCQITDPAA--ALVAPGSKMASSAVPEALHSIpviavdIAAVTRESEHSldaa 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  642 YPAENPDLpeAPDSLCYAIYTSGSTGQPKGVMVRHRalTNF-VCSIARQPGMLARDRLLSVTTFS----FDIFGL-ELYV 715
Cdd:PRK05857   159 SLAGNADQ--GSEDPLAMIFTSGTTGEPKAVLLANR--TFFaVPDILQKEGLNWVTWVVGETTYSplpaTHIGGLwWILT 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  716 PLARGASMLLASREQAqdpeALLDLVERQGVTVLQATPATWRMLCDSER-----VDLLRgctLLCGGEALAedLAARMRG 790
Cdd:PRK05857   235 CLMHGGLCVTGGENTT----SLLEILTTNAVATTCLVPTLLSKLVSELKsanatVPSLR---LVGYGGSRA--IAADVRF 305

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  791 LSAS---TWNLYGPTETTIWS----------ARFRLGEEARPFLGgplenTALYILDSE-MNPCPPGVA-----GELLIG 851
Cdd:PRK05857   306 IEATgvrTAQVYGLSETGCTAlclptddgsiVKIEAGAVGRPYPG-----VDVYLAATDgIGPTAPGAGpsasfGTLWIK 380

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  852 GDGLARGYHRRPGLTAErflpdpFAADGsrLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIEtRLLEQDS-VR 930
Cdd:PRK05857   381 SPANMLGYWNNPERTAE------VLIDG--WVNTGDLLERREDGFFYIKGRSSEMIICGGVNIAPDEVD-RIAEGVSgVR 451

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  931 EAVVVAQPGVAGPTLVAYLVpTEAALVDAESARqqelrsALKNSLLAVL---PDYMV-PAHMLLLENLPLTPNGKINRKA 1006
Cdd:PRK05857   452 EAACYEIPDEEFGALVGLAV-VASAELDESAAR------ALKHTIAARFrreSEPMArPSTIVIVTDIPRTQSGKVMRAS 524


                   .
gi 2183974163 1007 L 1007
Cdd:PRK05857   525 L 525

alpha_am_amid

TIGR03443

L-aminoadipate-semialdehyde dehydrogenase; Members of this protein family are ...

2879-3174

5.83e-13

Pssm-ID: 274582 [Multi-domain] Cd Length: 1389 Bit Score: 75.49 E-value: 5.83e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2879 AAWLILLQRFTGQDTVAFG--ATVSGRPAELRgieeqigLFINtlpvvaspcPEQPIGDWLQAVQGEnlalrefehtply 2956
Cdd:TIGR03443   54 AAFAALVYRLTGDEDIVLGtsSNKSGRPFVLR-------LNIT---------PELSFLQLYAKVSEE------------- 104

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2957 dIQRWAGQVGEAlFDNILvfeNYPVSAALAEETPADMRI---DALSNQE---QTHYPLTL---LVSAGETLELHYSYSRQ 3027
Cdd:TIGR03443  105 -EKEGASDIGVP-FDELS---EHIQAAKKLERTPPLFRLafqDAPDNQQttySTGSTTDLtvfLTPSSPELELSIYYNSL 179

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3028 AFDEAAIECLAERLERLLLGMCENPGASLGELDSLAVAERYQLLE-----GWnataAEYplqRG-VHRLFEEQVER---- 3097
Cdd:TIGR03443  180 LFSSDRITIVADQLAQLLSAASSNPDEPIGKVSLITPSQKSLLPDptkdlDW----SGF---RGaIHDIFADNAEKhpdr 252

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3098 -----TPTAPALAFGEERLDYAELNRRANRLAHALIERGIGADRLVGVAMERSIEMVVALMAILKAGGAYVPVDPEYPEE 3172
Cdd:TIGR03443  253 tcvveTPSFLDPSSKTRSFTYKQINEASNILAHYLLKTGIKRGDVVMIYAYRGVDLVVAVMGVLKAGATFSVIDPAYPPA 332


                   ..
gi 2183974163 3173 RQ 3174
Cdd:TIGR03443  333 RQ 334

PLN02330

4-coumarate--CoA ligase-like 1

498-1007

6.95e-13

4-coumarate--CoA ligase-like 1

Pssm-ID: 215189 [Multi-domain] Cd Length: 546 Bit Score: 74.25 E-value: 6.95e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  498 RSRLPASEYPAGQGVHRLFEAQAGLTPDAPALLFGE--ERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVV 575
Cdd:PLN02330    16 RSRYPSVPVPDKLTLPDFVLQDAELYADKVAFVEAVtgKAVTYGEVVRDTRRFAKALRSLGLRKGQVVVVVLPNVAEYGI 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  576 ALLAVLKAGGAYVPLDPQYPADRLQYMIDDSGLRLLLSQQSVLARLpQSDGLQSLLLDdlERLVHGypAEN-PDLPEAPD 654
Cdd:PLN02330    96 VALGIMAAGGVFSGANPTALESEIKKQAEAAGAKLIVTNDTNYGKV-KGLGLPVIVLG--EEKIEG--AVNwKELLEAAD 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  655 --------------SLCYAIYTSGSTGQPKGVMVRHRALTNFVCS--IARQPGMLARDRLLSVTTFsFDIFGLE--LYVP 716
Cdd:PLN02330   171 ragdtsdneeilqtDLCALPFSSGTTGISKGVMLTHRNLVANLCSslFSVGPEMIGQVVTLGLIPF-FHIYGITgiCCAT 249

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  717 LARGASMLLASReqaQDPEALLDLVERQGVTVLQATPATWRMLCDS---ERVDL--LRGCTLLCGGEALAEDL--AARMR 789
Cdd:PLN02330   250 LRNKGKVVVMSR---FELRTFLNALITQEVSFAPIVPPIILNLVKNpivEEFDLskLKLQAIMTAAAPLAPELltAFEAK 326

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  790 GLSASTWNLYGPTE---TTIWSARFRLGE--EARPFLGGPLENTALYILDSEMN-PCPPGVAGELLIGGDGLARGYHRRP 863
Cdd:PLN02330   327 FPGVQVQEAYGLTEhscITLTHGDPEKGHgiAKKNSVGFILPNLEVKFIDPDTGrSLPKNTPGELCVRSQCVMQGYYNNK 406

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  864 GLTAERFlpdpfaaDGSRLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQPGVAGP 943
Cdd:PLN02330   407 EETDRTI-------DEDGWLHTGDIGYIDDDGDIFIVDRIKELIKYKGFQVAPAELEAILLTHPSVEDAAVVPLPDEEAG 479

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2183974163  944 TLVAylvpteAALVDAESARQQElrSALKNSLLAVLPDYMVPAHMLLLENLPLTPNGKINRKAL 1007
Cdd:PLN02330   480 EIPA------ACVVINPKAKESE--EDILNFVAANVAHYKKVRVVQFVDSIPKSLSGKIMRRLL 535

PRK08308

acyl-CoA synthetase; Validated

1947-2077

7.41e-13

acyl-CoA synthetase; Validated

Pssm-ID: 236231 [Multi-domain] Cd Length: 414 Bit Score: 73.53 E-value: 7.41e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1947 TTGGRLYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVVLPHEGPGATQLVGYVVTQAAPS 2026
Cdd:PRK08308   287 KMGDKEIFTKDLGYKSERGTLHFMGRMDDVINVSGLNVYPIEVEDVMLRLPGVQEAVVYRGKDPVAGERVKAKVISHEEI 366

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2183974163 2027 DPAALRDTLRQalkaSLPEHMVPAHLLFLERLPLTANGKLDRRALPAPDAS 2077
Cdd:PRK08308   367 DPVQLREWCIQ----HLAPYQVPHEIESVTEIPKNANGKVSRKLLELGEVT 413

PRK08043

bifunctional acyl-ACP--phospholipid O-acyltransferase/long-chain-fatty-acid--ACP ligase;

1711-2067

8.72e-13

bifunctional acyl-ACP--phospholipid O-acyltransferase/long-chain-fatty-acid--ACP ligase;

Pssm-ID: 181207 [Multi-domain] Cd Length: 718 Bit Score: 74.36 E-value: 8.72e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1711 DNLAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRHWFGFSADD----AWSLFHsyAFDFSVwEIFGALLHGGRLVIVPye 1786
Cdd:PRK08043   365 EDAALILFTSGSEGHPKGVVHSHKSLLANVEQIKTIADFTPNDrfmsALPLFH--SFGLTV-GLFTPLLTGAEVFLYP-- 439

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1787 tsrSPEDFL---RLLCRERVTVLNQTpSAFkqLMQVACAGQEVPPLALRHVVFGGEALEVQALRPWFERFGdraPRLVNM 1863
Cdd:PRK08043   440 ---SPLHYRivpELVYDRNCTVLFGT-STF--LGNYARFANPYDFARLRYVVAGAEKLQESTKQLWQDKFG---LRILEG 510

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1864 YGITETTVHVTYR-PLsladldggAASP--IGEPIPDLswyllDAGLNPVP---RGciGELYVGGAGLARGYL--NRPEL 1935
Cdd:PRK08043   511 YGVTECAPVVSINvPM--------AAKPgtVGRILPGM-----DARLLSVPgieQG--GRLQLKGPNIMNGYLrvEKPGV 575

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1936 SCTRFVADPFSTTGGRLYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEA-RLLAQPGVAEAVVLPHEGPGATQ 2014
Cdd:PRK08043   576 LEVPTAENARGEMERGWYDTGDIVRFDEQGFVQIQGRAKRFAKIAGEMVSLEMVEQlALGVSPDKQHATAIKSDASKGEA 655

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2183974163 2015 LVGYVvtqaapSDPAALRDTLRQALKAS-LPEHMVPAHLLFLERLPLTANGKLD 2067
Cdd:PRK08043   656 LVLFT------TDSELTREKLQQYAREHgVPELAVPRDIRYLKQLPLLGSGKPD 703

C_PKS-NRPS

Condensation domain of hybrid polyketide synthetase/nonribosomal peptide synthetases (PKS ...

2672-2952

8.93e-13

Pssm-ID: 380471 [Multi-domain] Cd Length: 430 Bit Score: 73.45 E-value: 8.93e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2672 DPQRFREAWQAALDAHEVLRSGFLWQGalEKPLQLVRKRVEVPFSVHDWRDRADLAEALDALAAGEAGLGFELAEAPLLR 2751
Cdd:cd20483     37 DVNLLQKALSELVRRHEVLRTAYFEGD--DFGEQQVLDDPSFHLIVIDLSEAADPEAALDQLVRNLRRQELDIEEGEVIR 114

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2752 LVLVRTGERRHHLIYTNHHILMDGWSNSQLLGEVLQRYRGETPSRSDG-------RYRDYIAWLQR--QDAGRTE--AFW 2820
Cdd:cd20483    115 GWLVKLPDEEFALVLASHHIAWDRGSSKSIFEQFTALYDALRAGRDLAtvppppvQYIDFTLWHNAllQSPLVQPllDFW 194

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2821 KQRLQRLGEPTLLVPaFAHGVR--GAEGHADRYRQ-LDVTTSQRLAEFAREQKVTLNTLVQAAWLILLQRFTGQDTVAFG 2897
Cdd:cd20483    195 KEKLEGIPDASKLLP-FAKAERppVKDYERSTVEAtLDKELLARMKRICAQHAVTPFMFLLAAFRAFLYRYTEDEDLTIG 273

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2183974163 2898 ATVSGRP-AELrgiEEQIGLFINTLPVVASPCPEQPIGDWLQAVQGenLALREFEH 2952
Cdd:cd20483    274 MVDGDRPhPDF---DDLVGFFVNMLPIRCRMDCDMSFDDLLESTKT--TCLEAYEH 324

PP-binding

pfam00550

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...

1028-1087

9.59e-13

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.

Pssm-ID: 425746 [Multi-domain] Cd Length: 62 Bit Score: 65.28 E-value: 9.59e-13

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2183974163 1028 RAMAAIWSEVLKLGH--IGRDDNFFELGGHSLLVTQVVSRVRRRLDLQVPLRTLFEHSTLRA 1087
Cdd:pfam00550    1 ERLRELLAEVLGVPAeeIDPDTDLFDLGLDSLLAVELIARLEEEFGVEIPPSDLFEHPTLAE 62

PRK06018

putative acyl-CoA synthetase; Provisional

535-1014

1.15e-12

putative acyl-CoA synthetase; Provisional

Pssm-ID: 235673 [Multi-domain] Cd Length: 542 Bit Score: 73.63 E-value: 1.15e-12

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  535 RLSYAELNALANRLAWRLREEGVGS-DVLVGIALERGVPMVvALLAVLKAGGAYVPLDPQYPADRLQYMIDDSGLRLLLS 613
Cdd:PRK06018    39 RTTYAQIHDRALKVSQALDRDGIKLgDRVATIAWNTWRHLE-AWYGIMGIGAICHTVNPRLFPEQIAWIINHAEDRVVIT 117

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  614 QQSVLARLPQ-SDGLQSLllddlER-LVHGYPAENPDlPEAPDSLCYAI-----------------------YTSGSTGQ 668
Cdd:PRK06018   118 DLTFVPILEKiADKLPSV-----ERyVVLTDAAHMPQ-TTLKNAVAYEEwiaeadgdfawktfdentaagmcYTSGTTGD 191

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  669 PKGVMVRHRalTNFVCS-IARQP---GMLARDRLLSVT-TFSFDIFGLELYVPlARGASMLLASreqAQ-DPEALLDLVE 742
Cdd:PRK06018   192 PKGVLYSHR--SNVLHAlMANNGdalGTSAADTMLPVVpLFHANSWGIAFSAP-SMGTKLVMPG---AKlDGASVYELLD 265

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  743 RQGVTVLQATPATWRMLC---DSERVDLLRGCTLLCGGEALAEDLAARMRGLSASTWNLYGPTETtiwSARFRLGEEARP 819
Cdd:PRK06018   266 TEKVTFTAGVPTVWLMLLqymEKEGLKLPHLKMVVCGGSAMPRSMIKAFEDMGVEVRHAWGMTEM---SPLGTLAALKPP 342

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  820 FLGGPLE--------------NTALYILDSEMNPCP-PGVA-GELLIGGDGLARGYHRRPGltaerflpDPFAADGsrLY 883
Cdd:PRK06018   343 FSKLPGDarldvlqkqgyppfGVEMKITDDAGKELPwDGKTfGRLKVRGPAVAAAYYRVDG--------EILDDDG--FF 412

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  884 RTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQPGVA---GPTLVAYLVPteaalvdAE 960
Cdd:PRK06018   413 DTGDVATIDAYGYMRITDRSKDVIKSGGEWISSIDLENLAVGHPKVAEAAVIGVYHPKwdeRPLLIVQLKP-------GE 485

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2183974163  961 SARQQELRSALKNSllavLPDYMVPAHMLLLENLPLTPNGKINRKAL-------PLPDASA 1014
Cdd:PRK06018   486 TATREEILKYMDGK----IAKWWMPDDVAFVDAIPHTATGKILKTALreqfkdyKLPTAAA 542

FAA1

COG1022

Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism];

3076-3183

1.29e-12

Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism];

Pssm-ID: 440645 [Multi-domain] Cd Length: 603 Bit Score: 73.60 E-value: 1.29e-12

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3076 ATAAEYPLQRGVHRLFEEQVERTPTAPALAF----GEERLDYAELNRRANRLAHALIERGIGA-DRlVGVAMERSIEMVV 3150
Cdd:COG1022      2 SEFSDVPPADTLPDLLRRRAARFPDRVALREkedgIWQSLTWAEFAERVRALAAGLLALGVKPgDR-VAILSDNRPEWVI 80

                           90       100       110
                   ....*....|....*....|....*....|...
gi 2183974163 3151 ALMAILKAGGAYVPVDPEYPEERQAYMLEDSGV 3183
Cdd:COG1022     81 ADLAILAAGAVTVPIYPTSSAEEVAYILNDSGA 113

PRK07008

long-chain-fatty-acid--CoA ligase; Validated

1596-2086

2.51e-12

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 235908 [Multi-domain] Cd Length: 539 Bit Score: 72.43 E-value: 2.51e-12

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1596 YGELNLRANRLAHRLIELGVGPDVLVGLAA---ERSLEMIVGllaILKAGGAYVPLDPRYPSDRLGYMIEDSGIRLL--- 1669
Cdd:PRK07008    42 YRDCERRAKQLAQALAALGVEPGDRVGTLAwngYRHLEAYYG---VSGSGAVCHTINPRLFPEQIAYIVNHAEDRYVlfd 118

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1670 -----LTQRAA--------------RERLPlGEGLPCL----LLDAEHEWAGYPESDPQSAvgvdnlAYVIYTSGSTGKP 1726
Cdd:PRK07008   119 ltflpLVDALApqcpnvkgwvamtdAAHLP-AGSTPLLcyetLVGAQDGDYDWPRFDENQA------SSLCYTSGTTGNP 191

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1727 KGTLLPH-GNVLRLF-----DAtrhwFGFSADDAW----SLFHSYAfdfsvWEI-FGALLHGGRLVIV-PYETSRSpedF 1794
Cdd:PRK07008   192 KGALYSHrSTVLHAYgaalpDA----MGLSARDAVlpvvPMFHVNA-----WGLpYSAPLTGAKLVLPgPDLDGKS---L 259

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1795 LRLLCRERVTVLNQTPSAFKQLMQ-VACAGQEVPPlaLRHVVFGGEALEVQALRPWFERFGdraPRLVNMYGITE----- 1868
Cdd:PRK07008   260 YELIEAERVTFSAGVPTVWLGLLNhMREAGLRFST--LRRTVIGGSACPPAMIRTFEDEYG---VEVIHAWGMTEmsplg 334

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1869 TTVHVTYRPLSLADldgGAASPI----GEPIPDLSWYLLDAGLNPVPRG--CIGELYVGGAGLARGYLNRPelsctrfvA 1942
Cdd:PRK07008   335 TLCKLKWKHSQLPL---DEQRKLlekqGRVIYGVDMKIVGDDGRELPWDgkAFGDLQVRGPWVIDRYFRGD--------A 403

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1943 DPFSTtggRLYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEA--VVLPHegPGATQLVGYVV 2020
Cdd:PRK07008   404 SPLVD---GWFPTGDVATIDADGFMQITDRSKDVIKSGGEWISSIDIENVAVAHPAVAEAacIACAH--PKWDERPLLVV 478

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2183974163 2021 TQAAPSDpaALRDTLRQALKASLPEHMVPAHLLFLERLPLTANGKLDRRALpapdasRLQ-RDYTAP 2086
Cdd:PRK07008   479 VKRPGAE--VTREELLAFYEGKVAKWWIPDDVVFVDAIPHTATGKLQKLKL------REQfRDYVLP 537

FATP_chFAT1_like

cd05937

Uncharacterized subfamily of bifunctional fatty acid transporter/very-long-chain acyl-CoA ...

531-1007

4.25e-12

Pssm-ID: 341260 [Multi-domain] Cd Length: 468 Bit Score: 71.69 E-value: 4.25e-12

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  531 FGEERLSYAELNALANRLA-WRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQYMIDDSGLR 609
Cdd:cd05937      1 FEGKTWTYSETYDLVLRYAhWLHDDLGVQAGDFVAIDLTNSPEFVFLWLGLWSIGAAPAFINYNLSGDPLIHCLKLSGSR 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  610 LLLSQqsvlarlpqsdglqslllddlerlvhgypaenpdlpeaPDSLCYAIYTSGSTGQPKGVMVRHRALTNFVCSIARQ 689
Cdd:cd05937     81 FVIVD--------------------------------------PDDPAILIYTSGTTGLPKAAAISWRRTLVTSNLLSHD 122

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  690 PGMLARDRLLSVttfsfdifglelyVPLARGASMLLAsreqaqdpeALLDLVERQGVTVLQATPAT--WRMLCDSERVDL 767
Cdd:cd05937    123 LNLKNGDRTYTC-------------MPLYHGTAAFLG---------ACNCLMSGGTLALSRKFSASqfWKDVRDSGATII 180

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  768 L---RGCTLLCGGEALAEDLAARMR-----GLSASTWN-------------LYGPTETTIWSARFRLGeearPFLGGPLE 826
Cdd:cd05937    181 QyvgELCRYLLSTPPSPYDRDHKVRvawgnGLRPDIWErfrerfnvpeigeFYAATEGVFALTNHNVG----DFGAGAIG 256

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  827 NTALYI------------LDSE-----MNP-------CPPGVAGELLI----GGDGLARGYHRRPGLTAERFLPDPFAAd 878
Cdd:cd05937    257 HHGLIRrwkfenqvvlvkMDPEtddpiRDPktgfcvrAPVGEPGEMLGrvpfKNREAFQGYLHNEDATESKLVRDVFRK- 335

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  879 GSRLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVV--VAQPGVAGPTLVAYLVPTEAAL 956
Cdd:cd05937    336 GDIYFRTGDLLRQDADGRWYFLDRLGDTFRWKSENVSTTEVADVLGAHPDIAEANVygVKVPGHDGRAGCAAITLEESSA 415

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2183974163  957 VDAEsARQQELRS-ALKNsllavLPDYMVPAHMLLLENLPLTPNGKINRKAL 1007
Cdd:cd05937    416 VPTE-FTKSLLASlARKN-----LPSYAVPLFLRLTEEVATTDNHKQQKGVL 461

BACL_like

cd05929

Bacterial Bile acid CoA ligases and similar proteins; Bile acid-Coenzyme A ligase catalyzes ...

643-1007

4.66e-12

Pssm-ID: 341252 [Multi-domain] Cd Length: 473 Bit Score: 71.25 E-value: 4.66e-12

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  643 PAENPDLPEAPDSL-CYAIYTSGSTGQPKGVMVRHRALTNFVCSIARQP---GMLARDRLLSV------TTFSFDIFGLE 712
Cdd:cd05929    113 EGGSPETPIEDEAAgWKMLYSGGTTGRPKGIKRGLPGGPPDNDTLMAAAlgfGPGADSVYLSPaplyhaAPFRWSMTALF 192

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  713 LyvplarGASMLLASReqaQDPEALLDLVERQGVTVLQATPATW-RMLCDSERVdllRGctllcggealAEDLAARMRGL 791
Cdd:cd05929    193 M------GGTLVLMEK---FDPEEFLRLIERYRVTFAQFVPTMFvRLLKLPEAV---RN----------AYDLSSLKRVI 250

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  792 SAST------------------WNLYGPTE----TTIWSARF--RLGEEARPFLGGplentaLYILDSEMNPCPPGVAGE 847
Cdd:cd05929    251 HAAApcppwvkeqwidwggpiiWEYYGGTEgqglTIINGEEWltHPGSVGRAVLGK------VHILDEDGNEVPPGEIGE 324

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  848 L-LIGGDGLArgYHRRPGLTAERFLPDPFAAdgsrlyrTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQ 926
Cdd:cd05929    325 VyFANGPGFE--YTNDPEKTAAARNEGGWST-------LGDVGYLDEDGYLYLTDRRSDMIISGGVNIYPQEIENALIAH 395

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  927 DSVREAVVVaqpGVAGPTL---VAYLVPTeAALVDAESARQQELRSALKNSLLAvlpdYMVPAHMLLLENLPLTPNGKIN 1003
Cdd:cd05929    396 PKVLDAAVV---GVPDEELgqrVHAVVQP-APGADAGTALAEELIAFLRDRLSR----YKCPRSIEFVAELPRDDTGKLY 467


                   ....
gi 2183974163 1004 RKAL 1007
Cdd:cd05929    468 RRLL 471

FUM14_C_NRPS-like

Condensation domains of nonribosomal peptide synthetases (NRPSs) similar to the ester-bond ...

2174-2507

6.51e-12

Pssm-ID: 380467 [Multi-domain] Cd Length: 395 Bit Score: 70.40 E-value: 6.51e-12

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2174 PLLPIQQMFFELDIPRRQHW-NQSVLLEPgQALDGTLLETALQALLAHHDALRLGFRLEDGtwraeHRAVEA--GEVLLW 2250
Cdd:cd19545      3 PCTPLQEGLMALTARQPGAYvGQRVFELP-PDIDLARLQAAWEQVVQANPILRTRIVQSDS-----GGLLQVvvKESPIS 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2251 QQSVADGQalEALAEQVQRSLDLGsGPLLRALLATLGDGSQRLLLVIHHLVVDGVSWRILLEDLQTAYRQLQAGQavalp 2330
Cdd:cd19545     77 WTESTSLD--EYLEEDRAAPMGLG-GPLVRLALVEDPDTERYFVWTIHHALYDGWSLPLILRQVLAAYQGEPVPQ----- 148

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2331 akTSAFKAWAERLQAHARDGGlegeRGYWLAQLEGV-STELPCddregAQSVRHVRSARTELteEATRRLLQEAPAAYRT 2409
Cdd:cd19545    149 --PPPFSRFVKYLRQLDDEAA----AEFWRSYLAGLdPAVFPP-----LPSSRYQPRPDATL--EHSISLPSSASSGVTL 215

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2410 QVndLLLTALARVIGRWTGQADTLIQLEGHGREELFEDIDL----TRTVgwftslFPLR--LSPVAELGASIKRIKEQL- 2482
Cdd:cd19545    216 AT--VLRAAWALVLSRYTGSDDVVFGVTLSGRNAPVPGIEQivgpTIAT------VPLRvrIDPEQSVEDFLQTVQKDLl 287

                          330       340
                   ....*....|....*....|....*
gi 2183974163 2483 RAIPHKGLGFGALRYLGSaEDRAAL 2507
Cdd:cd19545    288 DMIPFEHTGLQNIRRLGP-DARAAC 311

prpE

PRK10524

propionyl-CoA synthetase; Provisional

494-1007

7.64e-12

propionyl-CoA synthetase; Provisional

Pssm-ID: 182517 [Multi-domain] Cd Length: 629 Bit Score: 71.13 E-value: 7.64e-12

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  494 TLLQRSRLP-ASEYPAGQ------GVHRLFEAQagltPDAPALLF-----GEER-LSYAELNALANRLAWRLREEGV--G 558
Cdd:PRK10524    34 QVLDYSNPPfARWFVGGRtnlchnAVDRHLAKR----PEQLALIAvstetDEERtYTFRQLHDEVNRMAAMLRSLGVqrG 109

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  559 SDVLVGIalergvPMV----VALLAVLKAGGAYVPLDPQYPADRLQYMIDDSGLRLLLSQQS------VLA--------- 619
Cdd:PRK10524   110 DRVLIYM------PMIaeaaFAMLACARIGAIHSVVFGGFASHSLAARIDDAKPVLIVSADAgsrggkVVPykplldeai 183

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  620 RLPQSDGLQSLLLD---DLERLVHG----YPAE-----NPDLP----EAPDSlCYAIYTSGSTGQPKGVmvrHR------ 677
Cdd:PRK10524   184 ALAQHKPRHVLLVDrglAPMARVAGrdvdYATLraqhlGARVPvewlESNEP-SYILYTSGTTGKPKGV---QRdtggya 259

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  678 -ALTNFVCSI-ARQPG--MLARDRLLSVTTFSFDIFGlelyvPLARG-ASMLLASREQAQDPEALLDLVERQGVTVLQAT 752
Cdd:PRK10524   260 vALATSMDTIfGGKAGetFFCASDIGWVVGHSYIVYA-----PLLAGmATIMYEGLPTRPDAGIWWRIVEKYKVNRMFSA 334

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  753 PATWRMLCDSE-----RVDL--LRgcTLLCGGEALAEDLAAR-MRGLSASTWNLYGPTETTiWS--ARFRlGEEARPF-L 821
Cdd:PRK10524   335 PTAIRVLKKQDpallrKHDLssLR--ALFLAGEPLDEPTASWiSEALGVPVIDNYWQTETG-WPilAIAR-GVEDRPTrL 410

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  822 GGPleNTALY-----ILDSEM-NPCPPGVAGELLIGGDglargyhRRPGLTA------ERFLPDPFAADGSRLYRTGDLA 889
Cdd:PRK10524   411 GSP--GVPMYgynvkLLNEVTgEPCGPNEKGVLVIEGP-------LPPGCMQtvwgddDRFVKTYWSLFGRQVYSTFDWG 481

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  890 RYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVaqpGVA----GPTLVAYLVPTEAALVDAESAR-- 963
Cdd:PRK10524   482 IRDADGYYFILGRTDDVINVAGHRLGTREIEESISSHPAVAEVAVV---GVKdalkGQVAVAFVVPKDSDSLADREARla 558

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....*
gi 2183974163  964 -QQELRSALKNSLLAVlpdyMVPAHMLLLENLPLTPNGKINRKAL 1007
Cdd:PRK10524   559 lEKEIMALVDSQLGAV----ARPARVWFVSALPKTRSGKLLRRAI 599

PP-binding

pfam00550

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...

2092-2149

8.72e-12

Pssm-ID: 425746 [Multi-domain] Cd Length: 62 Bit Score: 62.58 E-value: 8.72e-12

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2183974163 2092 QRLAAIWADVLKL--GRVGLDDNFFELGGDSIISIQVVSRARQA-GIRLAPRDLFLHQTIR 2149
Cdd:pfam00550    1 ERLRELLAEVLGVpaEEIDPDTDLFDLGLDSLLAVELIARLEEEfGVEIPPSDLFEHPTLA 61

PRK07768

long-chain-fatty-acid--CoA ligase; Validated

524-1006

9.32e-12

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 236091 [Multi-domain] Cd Length: 545 Bit Score: 70.80 E-value: 9.32e-12

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  524 PDAPallfgeERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLdpQYPADR--LQY 601
Cdd:PRK07768    24 PDAP------VRHTWGEVHERARRIAGGLAAAGVGPGDAVAVLAGAPVEIAPTAQGLWMRGASLTML--HQPTPRtdLAV 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  602 MIDDSGLRL-LLSQQSVL--------ARLPQSDGLQSLLLDDLerlVHGYPAENPDLPEapDSLCYAIYTSGSTGQPKGV 672
Cdd:PRK07768    96 WAEDTLRVIgMIGAKAVVvgepflaaAPVLEEKGIRVLTVADL---LAADPIDPVETGE--DDLALMQLTSGSTGSPKAV 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  673 MVRHRaltNFVCSIArqpGMLAR-------DRLLSVTTFSFDIfGLE--LYVPLARGASMLLAS-REQAQDPEALLDLVE 742
Cdd:PRK07768   171 QITHG---NLYANAE---AMFVAaefdvetDVMVSWLPLFHDM-GMVgfLTVPMYFGAELVKVTpMDFLRDPLLWAELIS 243

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  743 RQGVTVLQATPATWRMLC-------DSERVDL--LRgcTLLCGGE----ALAEDL--AARMRGLSASTW-NLYGPTETTI 806
Cdd:PRK07768   244 KYRGTMTAAPNFAYALLArrlrrqaKPGAFDLssLR--FALNGAEpidpADVEDLldAGARFGLRPEAIlPAYGMAEATL 321

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  807 ------WSARFRLGE------------------EARPF--LGGPLENTALYILDSEMNPCPPGVAGELLIGGDGLARGYh 860
Cdd:PRK07768   322 avsfspCGAGLVVDEvdadllaalrravpatkgNTRRLatLGPPLPGLEVRVVDEDGQVLPPRGVGVIELRGESVTPGY- 400

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  861 rrpgLTAERFLPdpfAADGSRLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQP-- 938
Cdd:PRK07768   401 ----LTMDGFIP---AQDADGWLDTGDLGYLTEEGEVVVCGRVKDVIIMAGRNIYPTDIERAAARVEGVRPGNAVAVRld 473

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2183974163  939 -GVAGPTLvAYLVPTEAALVDAESARqqeLRSALKNSLLAVLPdyMVPAHMLLLE--NLPLTPNGKINRKA 1006
Cdd:PRK07768   474 aGHSREGF-AVAVESNAFEDPAEVRR---IRHQVAHEVVAEVG--VRPRNVVVLGpgSIPKTPSGKLRRAN 538

Cyc_NRPS

Cyc (heterocyclization) domain of nonribosomal peptide synthetases (NRPSs); belongs to the ...

2666-2941

1.10e-11

Pssm-ID: 380458 [Multi-domain] Cd Length: 423 Bit Score: 69.82 E-value: 1.10e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2666 LDVEGLDPQRFREAWQAALDAHEVLRSGFLWQGalekpLQLVRKRVEVP-FSVHDWRDRADLAEaldalaagEAGLG--- 2741
Cdd:cd19535     32 FDGEDLDPDRLERAWNKLIARHPMLRAVFLDDG-----TQQILPEVPWYgITVHDLRGLSEEEA--------EAALEelr 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2742 -------FELAEAPLLRLVLVRTGERRHHLiytnhHI-----LMDGWSNSQLLGEVLQRYR--GETPSRSDGRYRDYIAW 2807
Cdd:cd19535     99 erlshrvLDVERGPLFDIRLSLLPEGRTRL-----HLsidllVADALSLQILLRELAALYEdpGEPLPPLELSFRDYLLA 173

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2808 LQRQDAGRTE---AFWKQRLQRL-GEPTLLV---------PAFAHgvrgaeghadRYRQLDVTTSQRLAEFAREQKVTLN 2874
Cdd:cd19535    174 EQALRETAYErarAYWQERLPTLpPAPQLPLakdpeeikePRFTR----------REHRLSAEQWQRLKERARQHGVTPS 243

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2183974163 2875 TLVQAAWLILLQRFTGQDTVAFGATVSGRPAELRGIEEQIGLFINTLPVVASPCPEQPIGDWLQAVQ 2941
Cdd:cd19535    244 MVLLTAYAEVLARWSGQPRFLLNLTLFNRLPLHPDVNDVVGDFTSLLLLEVDGSEGQSFLERARRLQ 310

hsFATP4_like

cd05939

Fatty acid transport proteins (FATP), including FATP4 and FATP1, and similar proteins; Fatty ...

1592-2071

1.14e-11

Fatty acid transport proteins (FATP), including FATP4 and FATP1, and similar proteins; Fatty acid transport protein (FATP) transports long-chain or very-long-chain fatty acids across the plasma membrane. At least five copies of FATPs are identified in mammalian cells. This family includes FATP4, FATP1, and homologous proteins. Each FATP has unique patterns of tissue distribution. FATP4 is mainly expressed in the brain, testis, colon and kidney. FATPs also have fatty acid CoA synthetase activity, thus playing dual roles as fatty acid transporters and its activation enzymes. FATPs are the key players in the trafficking of exogenous fatty acids into the cell and in intracellular fatty acid homeostasis.

Pssm-ID: 341262 [Multi-domain] Cd Length: 474 Bit Score: 70.15 E-value: 1.14e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1592 RALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAG--GAYVPLDPRYPSdrLGYMIEDSGIRLL 1669
Cdd:cd05939      2 RHWTFRELNEYSNKVANFFQAQGYRSGDVVALFMENRLEFVALWLGLAKIGveTALINSNLRLES--LLHCITVSKAKAL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1670 LTQraarerlplgeglpclLLDAEHEWAgypESDPQSAVGV---DNLAYvIYTSGSTGKPKGTLLPHGNVLRLFDATRHW 1746
Cdd:cd05939     80 IFN----------------LLDPLLTQS---STEPPSQDDVnfrDKLFY-IYTSGTTGLPKAAVIVHSRYYRIAAGAYYA 139

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1747 FGFSADD----AWSLFHSYAfdfsvwEIFG---ALLHGGRLVIvpyETSRSPEDFLRLLCRERVTV-----------LNQ 1808
Cdd:cd05939    140 FGMRPEDvvydCLPLYHSAG------GIMGvgqALLHGSTVVI---RKKFSASNFWDDCVKYNCTIvqyigeicrylLAQ 210

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1809 TPSAFKQLMQVacagqevpplalRHVVfgGEALEVQALRPWFERFgdRAPRLVNMYGITETTVhvtyrplSLADLDG--G 1886
Cdd:cd05939    211 PPSEEEQKHNV------------RLAV--GNGLRPQIWEQFVRRF--GIPQIGEFYGATEGNS-------SLVNIDNhvG 267

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1887 AAS----------PI---------GEPIPDlswylldaglnpvPRG-CI----GE--LYVG----GAGLAR--GYLNRPE 1934
Cdd:cd05939    268 ACGfnsrilpsvyPIrlikvdedtGELIRD-------------SDGlCIpcqpGEpgLLVGkiiqNDPLRRfdGYVNEGA 334

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1935 lSCTRFVADPFsTTGGRLYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVVLPHEGPGATQ 2014
Cdd:cd05939    335 -TNKKIARDVF-KKGDSAFLSGDVLVMDELGYLYFKDRTGDTFRWKGENVSTTEVEGILSNVLGLEDVVVYGVEVPGVEG 412

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2183974163 2015 LVGyvvtQAAPSDPAALRDT--LRQALKASLPEHMVPAHLLFLERLPLTANGKLDRRAL 2071
Cdd:cd05939    413 RAG----MAAIVDPERKVDLdrFSAVLAKSLPPYARPQFIRLLPEVDKTGTFKLQKTDL 467

PRK07008

long-chain-fatty-acid--CoA ligase; Validated

619-1002

1.40e-11

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 235908 [Multi-domain] Cd Length: 539 Bit Score: 70.12 E-value: 1.40e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  619 ARLPQSdglqSLLLDDLERLVHGYPAEN--PDLPE-APDSLCYaiyTSGSTGQPKGVMVRHRA--LTNFVCSIARQPGML 693
Cdd:PRK07008   145 AHLPAG----STPLLCYETLVGAQDGDYdwPRFDEnQASSLCY---TSGTTGNPKGALYSHRStvLHAYGAALPDAMGLS 217

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  694 ARDRLLSVT-TFSFDIFGLELYVPLArGASMLLASReqAQDPEALLDLVERQGVTVLQATPATWRMLCDSERVDLLRGCT 772
Cdd:PRK07008   218 ARDAVLPVVpMFHVNAWGLPYSAPLT-GAKLVLPGP--DLDGKSLYELIEAERVTFSAGVPTVWLGLLNHMREAGLRFST 294

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  773 L---LCGG--------EALAEDLAARMRglsastwNLYGPTE-------TTIWSARFRLGEEARPFL----GGPLENTAL 830
Cdd:PRK07008   295 LrrtVIGGsacppamiRTFEDEYGVEVI-------HAWGMTEmsplgtlCKLKWKHSQLPLDEQRKLlekqGRVIYGVDM 367

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  831 YILDSEMNPCP-PGVA-GELLIGGDGLARGYHRRpgltaerflpdpfaaDGSRLYR----TGDLARYRADGVIEYLGRID 904
Cdd:PRK07008   368 KIVGDDGRELPwDGKAfGDLQVRGPWVIDRYFRG---------------DASPLVDgwfpTGDVATIDADGFMQITDRSK 432

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  905 HQVKIRGFRIELGEIETrlleqdsvreaVVVAQPGVAGPTLVAYLVP--TEAALV------DAESARQQelrsalknsLL 976
Cdd:PRK07008   433 DVIKSGGEWISSIDIEN-----------VAVAHPAVAEAACIACAHPkwDERPLLvvvkrpGAEVTREE---------LL 492

                          410       420       430
                   ....*....|....*....|....*....|
gi 2183974163  977 AV----LPDYMVPAHMLLLENLPLTPNGKI 1002
Cdd:PRK07008   493 AFyegkVAKWWIPDDVVFVDAIPHTATGKL 522

PRK06178

acyl-CoA synthetase; Validated

3077-3183

1.48e-11

acyl-CoA synthetase; Validated

Pssm-ID: 235724 [Multi-domain] Cd Length: 567 Bit Score: 70.07 E-value: 1.48e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3077 TAAEYPL-QRGVHRLFEEQVERTPTAPALAFGEERLDYAELNRRANRLAHALIERGIGADRLVGVAMERSIEMVVALMAI 3155
Cdd:PRK06178    24 REPEYPHgERPLTEYLRAWARERPQRPAIIFYGHVITYAELDELSDRFAALLRQRGVGAGDRVAVFLPNCPQFHIVFFGI 103

                           90       100
                   ....*....|....*....|....*...
gi 2183974163 3156 LKAGGAYVPVDPEYPEERQAYMLEDSGV 3183
Cdd:PRK06178   104 LKLGAVHVPVSPLFREHELSYELNDAGA 131

A_NRPS_MycA_like

cd05908

The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin ...

644-936

1.92e-11

The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin synthase subunit A (MycA); The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as (amino)-acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. This family includes NRPS similar to mycosubtilin synthase subunit A (MycA). Mycosubtilin, which is characterized by a beta-amino fatty acid moiety linked to the circular heptapeptide Asn-Tyr-Asn-Gln-Pro-Ser-Asn, belongs to the iturin family of lipopeptide antibiotics. The mycosubtilin synthase subunit A (MycA) combines functional domains derived from peptide synthetases, amino transferases, and fatty acid synthases. Nonribosomal peptide synthetases are large multifunction enzymes that synthesize many therapeutically useful peptides. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and, in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.

Pssm-ID: 341234 [Multi-domain] Cd Length: 499 Bit Score: 69.44 E-value: 1.92e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  644 AENPDLPEAPDSLCYAIYTSGSTGQPKGVMVRHRALTNFVCSIARQPGMLARDRLLSVTTFSFDIfGLELY--VPLARGA 721
Cdd:cd05908     96 TEEEVLCELADELAFIQFSSGSTGDPKGVMLTHENLVHNMFAILNSTEWKTKDRILSWMPLTHDM-GLIAFhlAPLIAGM 174

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  722 S-MLLASREQAQDPEALLDLVERQGVTVLQATPATWRMLCD------SERVDLLRGCTLLCGGEALAEDLAAR-MRGLSA 793
Cdd:cd05908    175 NqYLMPTRLFIRRPILWLKKASEHKATIVSSPNFGYKYFLKtlkpekANDWDLSSIRMILNGAEPIDYELCHEfLDHMSK 254

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  794 ------STWNLYGPTETTIWSARFRLGEEARPF----------------------------LGGPLENTALYILDSEMNP 839
Cdd:cd05908    255 yglkrnAILPVYGLAEASVGASLPKAQSPFKTItlgrrhvthgepepevdkkdsecltfveVGKPIDETDIRICDEDNKI 334

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  840 CPPGVAGELLIGGDGLARGYHRRPGLTAERFLPDPFaadgsrlYRTGDLARYRaDGVIEYLGRIDHQVKIRGFRIELGEI 919
Cdd:cd05908    335 LPDGYIGHIQIRGKNVTPGYYNNPEATAKVFTDDGW-------LKTGDLGFIR-NGRLVITGREKDIIFVNGQNVYPHDI 406

                          330
                   ....*....|....*..
gi 2183974163  920 ETRLLEQDSVREAVVVA 936
Cdd:cd05908    407 ERIAEELEGVELGRVVA 423

EntE

COG1021

EntE, 2,3-dihydroxybenzoate-AMP synthase component of non-ribosomal peptide synthetase ...

3063-3165

3.21e-11

EntE, 2,3-dihydroxybenzoate-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism];

Pssm-ID: 440644 [Multi-domain] Cd Length: 533 Bit Score: 69.02 E-value: 3.21e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3063 AVAERYQllegwnatAAEYPLQRGVHRLFEEQVERTPTAPALAFGEERLDYAELNRRANRLAHALIERGIGA-DRLVgVA 3141
Cdd:COG1021     11 EFAARYR--------EAGYWRGETLGDLLRRRAERHPDRIAVVDGERRLSYAELDRRADRLAAGLLALGLRPgDRVV-VQ 81

                           90       100
                   ....*....|....*....|....
gi 2183974163 3142 MERSIEMVVALMAILKAGGayVPV 3165
Cdd:COG1021     82 LPNVAEFVIVFFALFRAGA--IPV 103

PRK04813

D-alanine--poly(phosphoribitol) ligase subunit DltA;

3091-3173

3.22e-11

D-alanine--poly(phosphoribitol) ligase subunit DltA;

Pssm-ID: 235313 [Multi-domain] Cd Length: 503 Bit Score: 68.77 E-value: 3.22e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3091 FEEQVERTPTAPALAFGEERLDYAELNRRANRLAHALIERGIGADRLVGVAMERSIEMVVALMAILKAGGAYVPVDPEYP 3170
Cdd:PRK04813     8 IEEFAQTQPDFPAYDYLGEKLTYGQLKEDSDALAAFIDSLKLPDKSPIIVFGHMSPEMLATFLGAVKAGHAYIPVDVSSP 87


                   ...
gi 2183974163 3171 EER 3173
Cdd:PRK04813    88 AER 90

AFD_CAR-like

cd17632

adenylation domain of carboxylic acid reductase (CAR); This family contains the adenylation ...

1674-2066

3.57e-11

Pssm-ID: 341287 [Multi-domain] Cd Length: 588 Bit Score: 69.02 E-value: 3.57e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1674 AARERLP-LGEGLPCLLLDAEHEWAGYPESDPQSAVGVDNLAYVIYTSGSTGKPKGTLLPHGNVLRLfdatrhWFGFSAD 1752
Cdd:cd17632    185 SARERLAaVGIPVTTLTLIAVRGRDLPPAPLFRPEPDDDPLALLIYTSGSTGTPKGAMYTERLVATF------WLKVSSI 258

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1753 DAWSLFHSYAFDF--------SVWeIFGALLHGGrlviVPYETSRSpeDFLRL---LCRERVTVLNQTPSAFKQLMQ--- 1818
Cdd:cd17632    259 QDIRPPASITLNFmpmshiagRIS-LYGTLARGG----TAYFAAAS--DMSTLfddLALVRPTELFLVPRVCDMLFQryq 331

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1819 -----VACAGQEVPPLA------LRHVVFGGE---ALEVQA-----LRPWFERFGDRapRLVNMYGITETTV----HVTY 1875
Cdd:cd17632    332 aeldrRSVAGADAETLAervkaeLRERVLGGRllaAVCGSAplsaeMKAFMESLLDL--DLHDGYGSTEAGAvildGVIV 409

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1876 RP----LSLADldggaaspigepIPDLSWYLLDaglNPVPRGcigELYVGGAGLARGYLNRPELSCTRFVADPFsttggr 1951
Cdd:cd17632    410 RPpvldYKLVD------------VPELGYFRTD---RPHPRG---ELLVKTDTLFPGYYKRPEVTAEVFDEDGF------ 465

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1952 lYRTGD-LARYRCDGVVeYVGRIDHQVKI-RGFRIELGEIEARLLAQPGVAE-------------AVVLPHEGPgatqLV 2016
Cdd:cd17632    466 -YRTGDvMAELGPDRLV-YVDRRNNVLKLsQGEFVTVARLEAVFAASPLVRQifvygnserayllAVVVPTQDA----LA 539

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2183974163 2017 GYVVTQAAPsdpaALRDTL-RQALKASLPEHMVPAHLLfLERLPLT-ANGKL 2066
Cdd:cd17632    540 GEDTARLRA----ALAESLqRIAREAGLQSYEIPRDFL-IETEPFTiANGLL 586

FCS

cd05921

Feruloyl-CoA synthetase (FCS); Feruloyl-CoA synthetase is an essential enzyme in the feruloyl ...

1574-2046

4.14e-11

Feruloyl-CoA synthetase (FCS); Feruloyl-CoA synthetase is an essential enzyme in the feruloyl acid degradation pathway and enables some proteobacteria to grow on media containing feruloyl acid as the sole carbon source. It catalyzes the transfer of CoA to the carboxyl group of ferulic acid, which then forms feruloyl-CoA in the presence of ATP and Mg2. The resulting feruloyl-CoA is further degraded to vanillin and acetyl-CoA. Feruloyl-CoA synthetase (FCS) is a subfamily of the adenylate-forming enzymes superfamily.

Pssm-ID: 341245 [Multi-domain] Cd Length: 561 Bit Score: 68.61 E-value: 4.14e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1574 IERQAAERPRATAVVYGE-----RALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPL 1648
Cdd:cd05921      1 LAHWARQAPDRTWLAEREgnggwRRVTYAEALRQVRAIAQGLLDLGLSAERPLLILSGNSIEHALMALAAMYAGVPAAPV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1649 DPRYPS-----DRLGYMIEDSGIRLLLTQ------RAARERLPLG----------EGLPCLLLDAEHEWAGYPESDPQ-S 1706
Cdd:cd05921     81 SPAYSLmsqdlAKLKHLFELLKPGLVFAQdaapfaRALAAIFPLGtplvvsrnavAGRGAISFAELAATPPTAAVDAAfA 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1707 AVGVDNLAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRHWFGFSADD--------AWSlfHSYAFDfsvwEIFGALLH-G 1777
Cdd:cd05921    161 AVGPDTVAKFLFTSGSTGLPKAVINTQRMLCANQAMLEQTYPFFGEEppvlvdwlPWN--HTFGGN----HNFNLVLYnG 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1778 GRLVIvpYETSRSPEDF---LRLLCRERVTVLNQTPSAFKQLMQvacAGQEVPPLA------LRHVVFGGEAL------E 1842
Cdd:cd05921    235 GTLYI--DDGKPMPGGFeetLRNLREISPTVYFNVPAGWEMLVA---ALEKDEALRrrffkrLKLMFYAGAGLsqdvwdR 309

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1843 VQALRpwFERFGDRAPrLVNMYGITET--TVHVTYRPLSLADLdggaaspIGEPIPDLSWYLldaglnpVPRGCIGELYV 1920
Cdd:cd05921    310 LQALA--VATVGERIP-MMAGLGATETapTATFTHWPTERSGL-------IGLPAPGTELKL-------VPSGGKYEVRV 372

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1921 GGAGLARGYLNRPELSCTRFVADPFsttggrlYRTGDLARYRCD-----GVVeYVGRIDHQVKIR-GFRIELGEIEARLL 1994
Cdd:cd05921    373 KGPNVTPGYWRQPELTAQAFDEEGF-------YCLGDAAKLADPddpakGLV-FDGRVAEDFKLAsGTWVSVGPLRARAV 444

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2183974163 1995 AQ--PGVAEAVVLPHEG--------PGATQLVGYVVTQAAPSDPAALRDTLRQALKASLPEH 2046
Cdd:cd05921    445 AAcaPLVHDAVVAGEDRaevgalvfPDLLACRRLVGLQEASDAEVLRHAKVRAAFRDRLAAL 506

PLN02860

o-succinylbenzoate-CoA ligase

1567-2005

4.86e-11

o-succinylbenzoate-CoA ligase

Pssm-ID: 215464 [Multi-domain] Cd Length: 563 Bit Score: 68.29 E-value: 4.86e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1567 ASCLHRLierqAAERPRATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYV 1646
Cdd:PLN02860    10 CQCLTRL----ATLRGNAVVTISGNRRRTGHEFVDGVLSLAAGLLRLGLRNGDVVAIAALNSDLYLEWLLAVACAGGIVA 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1647 PLDPRYPSDRLGYMIEDSGIRLLLTQRAAR---ERLPLGE----------GLPCL--------LLDAEHEWA---GYPES 1702
Cdd:PLN02860    86 PLNYRWSFEEAKSAMLLVRPVMLVTDETCSswyEELQNDRlpslmwqvflESPSSsvfiflnsFLTTEMLKQralGTTEL 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1703 DPQSAvgVDNLAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRHWFGFSADDAW----SLFH----SYAfdfsvweiFGAL 1774
Cdd:PLN02860   166 DYAWA--PDDAVLICFTSGTTGRPKGVTISHSALIVQSLAKIAIVGYGEDDVYlhtaPLCHigglSSA--------LAML 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1775 LHGGRLVIVP-YETSRSpedfLRLLCRERVTVLNQTPSAFKQLMQVA---CAGQEVPplALRHVVFGGEALEVQALRPWF 1850
Cdd:PLN02860   236 MVGACHVLLPkFDAKAA----LQAIKQHNVTSMITVPAMMADLISLTrksMTWKVFP--SVRKILNGGGSLSSRLLPDAK 309

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1851 ERFgDRApRLVNMYGITETTVHVTYRPLSLADLDGGAASPIGEPIPDLSwylldagLNPVPRG-CIG------ELYVG-- 1921
Cdd:PLN02860   310 KLF-PNA-KLFSAYGMTEACSSLTFMTLHDPTLESPKQTLQTVNQTKSS-------SVHQPQGvCVGkpaphvELKIGld 380

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1922 -----GAGLARGylnrPELsCTRFVADPFSTTGGRL----YRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEAR 1992
Cdd:PLN02860   381 essrvGRILTRG----PHV-MLGYWGQNSETASVLSndgwLDTGDIGWIDKAGNLWLIGRSNDRIKTGGENVYPEEVEAV 455

                          490
                   ....*....|...
gi 2183974163 1993 LLAQPGVAEAVVL 2005
Cdd:PLN02860   456 LSQHPGVASVVVV 468

PRK05620

long-chain fatty-acid--CoA ligase;

1596-2071

5.87e-11

long-chain fatty-acid--CoA ligase;

Pssm-ID: 180167 [Multi-domain] Cd Length: 576 Bit Score: 68.27 E-value: 5.87e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1596 YGELNLRANRLAHRLI-ELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPL-----------------------DPR 1651
Cdd:PRK05620    41 FAAIGARAAALAHALHdELGITGDQRVGSMMYNCAEHLEVLFAVACMGAVFNPLnkqlmndqivhiinhaedevivaDPR 120

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1652 YpSDRLGYMIED----SGIRLLLTQRAARERLPLGEGLPCL----LLD---AEHEWAGYPESDPqsavgvdnlAYVIYTS 1720
Cdd:PRK05620   121 L-AEQLGEILKEcpcvRAVVFIGPSDADSAAAHMPEGIKVYsyeaLLDgrsTVYDWPELDETTA---------AAICYST 190

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1721 GSTGKPKGTLLPHgNVLRLfdatrHWFGFSADDAWSLFHSYAFDFSV-------WEI-FGALLHGGRLVIVPYETsrSPE 1792
Cdd:PRK05620   191 GTTGAPKGVVYSH-RSLYL-----QSLSLRTTDSLAVTHGESFLCCVpiyhvlsWGVpLAAFMSGTPLVFPGPDL--SAP 262

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1793 DFLRLLCRERVTVLNQTPSAFKQLMqvaCAGQEVPP--LALRHVVFGGEALEVQALRPWFERFGdraPRLVNMYGITET- 1869
Cdd:PRK05620   263 TLAKIIATAMPRVAHGVPTLWIQLM---VHYLKNPPerMSLQEIYVGGSAVPPILIKAWEERYG---VDVVHVWGMTETs 336

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1870 TVHVTYRPLSLADLDGGAASPIGE---PIpDLSWYLLDAG--LNPVPRGCiGELYVGGAGLARGYLNRP----------- 1933
Cdd:PRK05620   337 PVGTVARPPSGVSGEARWAYRVSQgrfPA-SLEYRIVNDGqvMESTDRNE-GEIQVRGNWVTASYYHSPteegggaastf 414

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1934 -----ELSCTRFVADpfsttgGRLyRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVVL--P 2006
Cdd:PRK05620   415 rgedvEDANDRFTAD------GWL-RTGDVGSVTRDGFLTIHDRARDVIRSGGEWIYSAQLENYIMAAPEVVECAVIgyP 487

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2183974163 2007 HEGPGATQLvgyVVTQAAPSDP--AALRDTLRQALKASLPEHMVPAHLLFLERLPLTANGKLDRRAL 2071
Cdd:PRK05620   488 DDKWGERPL---AVTVLAPGIEptRETAERLRDQLRDRLPNWMLPEYWTFVDEIDKTSVGKFDKKDL 551

X-Domain_NRPS

X-domain is a catalytically inactive Condensation-like domain shown to recruit oxygenases to ...

2196-2464

6.17e-11

Pssm-ID: 380468 [Multi-domain] Cd Length: 440 Bit Score: 67.50 E-value: 6.17e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2196 SVLLEPGQALDGTLLETALQALLAHHDALRLGFRLEDGTWRAEHRAVEAGEVLLWQQSVADGQALEALAEQVQRSLDLGS 2275
Cdd:cd19546     30 SVALRLRGRLDRDALEAALGDVAARHEILRTTFPGDGGDVHQRILDADAARPELPVVPATEEELPALLADRAAHLFDLTR 109

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2276 GPLLRALLATLGDGSQRLLLVIHHLVVDGVSWRILLEDLQTAYRQLQAGQA---VALPAKTSAFKAWAERLQAHARDG-G 2351
Cdd:cd19546    110 ETPWRCTLFALSDTEHVLLLVVHRIAADDESLDVLVRDLAAAYGARREGRAperAPLPLQFADYALWERELLAGEDDRdS 189

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2352 LEGER-GYWLAQLEGV--STELPCDDREGAQSVRHVRSARTELTEEATRRLLQEAPAAYRTQVNdLLLTALARVIGRWTG 2428
Cdd:cd19546    190 LIGDQiAYWRDALAGApdELELPTDRPRPVLPSRRAGAVPLRLDAEVHARLMEAAESAGATMFT-VVQAALAMLLTRLGA 268

                          250       260       270
                   ....*....|....*....|....*....|....*.
gi 2183974163 2429 QADTLIQLEGHGREELfedIDLTRTVGWFTSLFPLR 2464
Cdd:cd19546    269 GTDVTVGTVLPRDDEE---GDLEGMVGPFARPLALR 301

MCS

cd05941

Malonyl-CoA synthetase (MCS); MCS catalyzes the formation of malonyl-CoA in a two-step ...

3101-3183

7.81e-11

Pssm-ID: 341264 [Multi-domain] Cd Length: 442 Bit Score: 67.31 E-value: 7.81e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3101 APALAFGEERLDYAELNRRANRLAHALIERG--IGADRlVGVAMERSIEMVVALMAILKAGGAYVPVDPEYPEERQAYML 3178
Cdd:cd05941      2 RIAIVDDGDSITYADLVARAARLANRLLALGkdLRGDR-VAFLAPPSAEYVVAQLAIWRAGGVAVPLNPSYPLAELEYVI 80


                   ....*
gi 2183974163 3179 EDSGV 3183
Cdd:cd05941     81 TDSEP 85

E_NRPS

Epimerization domain of nonribosomal peptide synthetases (NRPSs); belongs to the ...

2637-3035

8.26e-11

Pssm-ID: 380457 [Multi-domain] Cd Length: 428 Bit Score: 67.28 E-value: 8.26e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2637 LYPLSPMQQgmLFHSLYQQNSGDYiNQ-MRLDV-EGLDPQRFREAWQAALDAHEVLRSGFL-----WQGALEKPLQLVrk 2709
Cdd:cd19534      1 EVPLTPIQR--WFFEQNLAGRHHF-NQsVLLRVpQGLDPDALRQALRALVEHHDALRMRFRredggWQQRIRGDVEEL-- 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2710 rveVPFSVHDWRDRADLAEALDALAagEAGLGFELAEAPLLRLVLVRTGERRHHLIYTNHHILMDGWSNSQLLGEVLQRY 2789
Cdd:cd19534     76 ---FRLEVVDLSSLAQAAAIEALAA--EAQSSLDLEEGPLLAAALFDGTDGGDRLLLVIHHLVVDGVSWRILLEDLEAAY 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2790 RGE--------TPSRSdgrYRDYIAWLqrQDAGRTEAFWKQRLQRLGEPTLLVPAFAHGVRGAEGHADRYR-QLDV-TTS 2859
Cdd:cd19534    151 EQAlagepiplPSKTS---FQTWAELL--AEYAQSPALLEELAYWRELPAADYWGLPKDPEQTYGDARTVSfTLDEeETE 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2860 QRLAEFAREQKVTLNTLVQAAWLILLQRFTGQDTVAfgatVS----GRPAELRGIE--EQIGLFINTLPVVASPCPEQPI 2933
Cdd:cd19534    226 ALLQEANAAYRTEINDLLLAALALAFQDWTGRAPPA----IFleghGREEIDPGLDlsRTVGWFTSMYPVVLDLEASEDL 301

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2934 GDWLQAVQgENLalrefEHTPL----YDIQRWAGQVGEALFDNIL----VFeNY------PVSAALAEETPADMRIDALS 2999
Cdd:cd19534    302 GDTLKRVK-EQL-----RRIPNkgigYGILRYLTPEGTKRLAFHPqpeiSF-NYlgqfdqGERDDALFVSAVGGGGSDIG 374

                          410       420       430
                   ....*....|....*....|....*....|....*...
gi 2183974163 3000 NQEQTHYPL--TLLVSAGEtLELHYSYSRQAFDEAAIE 3035
Cdd:cd19534    375 PDTPRFALLdiNAVVEGGQ-LVITVSYSRNMYHEETIQ 411

E-C_NRPS

Dual Epimerization/Condensation (E/C) domains of nonribosomal peptide synthetases (NRPSs); ...

2213-2431

8.78e-11

Pssm-ID: 380466 [Multi-domain] Cd Length: 413 Bit Score: 67.08 E-value: 8.78e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2213 ALQALLAHHDALRLGFRLEDGT------WRaehRAVEAGEVLLWQQSVADGQALEALAEQVQRSLDLGSGPLLRALLATL 2286
Cdd:cd19544     44 ALQQVIDRHDILRTAILWEGLSepvqvvWR---QAELPVEELTLDPGDDALAQLRARFDPRRYRLDLRQAPLLRAHVAED 120

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2287 GDGSQRLLLV-IHHLVVDGVSWRILLEDLQtayrQLQAGQAVALPAKTSaFKawaeRLQAHARDGGLEGE-RGYWLAQLE 2364
Cdd:cd19544    121 PANGRWLLLLlFHHLISDHTSLELLLEEIQ----AILAGRAAALPPPVP-YR----NFVAQARLGASQAEhEAFFREMLG 191

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2183974163 2365 GVsTE--LPCDDREGAQSVRHVRSARTELTEEATRRLLQEA------PAAyrtqvndLLLTALARVIGRWTGQAD 2431
Cdd:cd19544    192 DV-DEptAPFGLLDVQGDGSDITEARLALDAELAQRLRAQArrlgvsPAS-------LFHLAWALVLARCSGRDD 258

PRK08180

feruloyl-CoA synthase; Reviewed

485-891

9.19e-11

feruloyl-CoA synthase; Reviewed

Pssm-ID: 236175 [Multi-domain] Cd Length: 614 Bit Score: 67.60 E-value: 9.19e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  485 PLLDAEERA--TLLQRSRLPASEYPAGQGvHRLfEAQAGLTPDAPAL-----LFGEERLSYAELNALANRLAWRLREEGV 557
Cdd:PRK08180    14 PAVEVERRAdgTIYLRSAEPLGDYPRRLT-DRL-VHWAQEAPDRVFLaergaDGGWRRLTYAEALERVRAIAQALLDRGL 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  558 GSD----VLVGIALERGVPMvvalLAVLKAGGAYVPLDPQY---PAD--RLQYMID---------DSGLR-------LLL 612
Cdd:PRK08180    92 SAErplmILSGNSIEHALLA----LAAMYAGVPYAPVSPAYslvSQDfgKLRHVLElltpglvfaDDGAAfaralaaVVP 167

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  613 SQQSVLARLPQSDGLQSLLLDDLERlvhgyPAENPDLPEA-----PDSLCYAIYTSGSTGQPKGVMVRHRALtnfvCSIA 687
Cdd:PRK08180   168 ADVEVVAVRGAVPGRAATPFAALLA-----TPPTAAVDAAhaavgPDTIAKFLFTSGSTGLPKAVINTHRML----CANQ 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  688 RqpgMLARdrllsvtTFSFD---------------------IFGLELYvplaRGASMLLASRE--QAQDPEALLDLVERQ 744
Cdd:PRK08180   239 Q---MLAQ-------TFPFLaeeppvlvdwlpwnhtfggnhNLGIVLY----NGGTLYIDDGKptPGGFDETLRNLREIS 304

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  745 GvTVLQATPATWRMLCDSERVDllrgctllcggEALAEDLAARMR-------GLSASTWNL------------------Y 799
Cdd:PRK08180   305 P-TVYFNVPKGWEMLVPALERD-----------AALRRRFFSRLKllfyagaALSQDVWDRldrvaeatcgerirmmtgL 372

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  800 GPTETTIwSARFRLGEEARP-FLGGPLENTALYILdsemnpcPPGVAGELLIGGDGLARGYHRRPGLTAERFLPDPFaad 878
Cdd:PRK08180   373 GMTETAP-SATFTTGPLSRAgNIGLPAPGCEVKLV-------PVGGKLEVRVKGPNVTPGYWRAPELTAEAFDEEGY--- 441

                          490
                   ....*....|...
gi 2183974163  879 gsrlYRTGDLARY 891
Cdd:PRK08180   442 ----YRSGDAVRF 450

entF

enterobactin non-ribosomal peptide synthetase EntF;

2193-2431

1.03e-10

enterobactin non-ribosomal peptide synthetase EntF;

Pssm-ID: 236668 [Multi-domain] Cd Length: 1296 Bit Score: 68.15 E-value: 1.03e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2193 WNQSVLLEPGQALDGTLLETALQALLAHHDALRLGFRLEDGTWR----AEHRAVEAGEVLLWQQSVADGQALEALAEQVQ 2268
Cdd:PRK10252    30 WSVAHYVELTGELDAPLLARAVVAGLAEADTLRMRFTEDNGEVWqwvdPALTFPLPEIIDLRTQPDPHAAAQALMQADLQ 109

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2269 RSLDLGSG-PLLRALLATLGDGSQRLLLVIHHLVVDGVSWRILLEDLQTAYRQLQAGQavalPAKTSAFKAWAERL---Q 2344
Cdd:PRK10252   110 QDLRVDSGkPLVFHQLIQLGDNRWYWYQRYHHLLVDGFSFPAITRRIAAIYCAWLRGE----PTPASPFTPFADVVeeyQ 185

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2345 AHARDGGLEGERGYWLAQLEGVS--TELPCDDREGAQSVRHVRSARTELTEEATRRLLQEAPAAYRTqvnDLLLTALARV 2422
Cdd:PRK10252   186 RYRASEAWQRDAAFWAEQRRQLPppASLSPAPLPGRSASADILRLKLEFTDGAFRQLAAQASGVQRP---DLALALVALW 262


                   ....*....
gi 2183974163 2423 IGRWTGQAD 2431
Cdd:PRK10252   263 LGRLCGRMD 271

AACS

cd05943

Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); AACS is a cytosolic ligase that ...

1546-2065

1.22e-10

Pssm-ID: 341265 [Multi-domain] Cd Length: 629 Bit Score: 67.30 E-value: 1.22e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1546 DEAEARADLLQWNPGPQ-DFtpASCLHRlierqAAERPRATAVVYGE----RALDYGELNLRANRLAHRLIELGVGP-DV 1619
Cdd:cd05943     53 VVSGRIMPGARWFPGARlNY--AENLLR-----HADADDPAAIYAAEdgerTEVTWAELRRRVARLAAALRALGVKPgDR 125

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1620 LVGLAAErSLEMIVGLLAILKAGGAYVPLDPRYPS----DRLG------------YMIEDSGIRLLLTQRAARERLPLGE 1683
Cdd:cd05943    126 VAGYLPN-IPEAVVAMLATASIGAIWSSCSPDFGVpgvlDRFGqiepkvlfavdaYTYNGKRHDVREKVAELVKGLPSLL 204

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1684 G---LPCLLLDAEHEWAGYPES--------DPQSA------VGVDNLAYVIYTSGSTGKPK-------GTLLPHGNVLRL 1739
Cdd:cd05943    205 AvvvVPYTVAAGQPDLSKIAKAltledflaTGAAGelefepLPFDHPLYILYSSGTTGLPKcivhgagGTLLQHLKEHIL 284

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1740 -FDATRH--WFGFSADdAWSLFHsyafdfsvWEIfGALLHGGRLVIvpYETS---RSPEDFLRLLCRERVTVLNQTPsaf 1813
Cdd:cd05943    285 hCDLRPGdrLFYYTTC-GWMMWN--------WLV-SGLAVGATIVL--YDGSpfyPDTNALWDLADEEGITVFGTSA--- 349

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1814 KQLMqvACAGQEVPP------LALRHVVFGGEALEVQALRpWFERfgdraprlvnmygitettvHVTYRpLSLADLDGGA 1887
Cdd:cd05943    350 KYLD--ALEKAGLKPaethdlSSLRTILSTGSPLKPESFD-YVYD-------------------HIKPD-VLLASISGGT 406

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1888 aspigepipDL-SWYLLDAGLNPVPRGCIGELYVGGAGLARGYLNRP------ELSCTR--------FVADP-------- 1944
Cdd:cd05943    407 ---------DIiSCFVGGNPLLPVYRGEIQCRGLGMAVEAFDEEGKPvwgekgELVCTKpfpsmpvgFWNDPdgsryraa 477

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1945 -FSTTGGrLYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVVLPHEGP-GATQLVGYVVTQ 2022
Cdd:cd05943    478 yFAKYPG-VWAHGDWIEITPRGGVVILGRSDGTLNPGGVRIGTAEIYRVVEKIPEVEDSLVVGQEWKdGDERVILFVKLR 556

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|...
gi 2183974163 2023 AAPSDPAALRDTLRQALKASLPEHMVPAHLLFLERLPLTANGK 2065
Cdd:cd05943    557 EGVELDDELRKRIRSTIRSALSPRHVPAKIIAVPDIPRTLSGK 599

PRK05850

acyl-CoA synthetase; Validated

520-911

1.24e-10

acyl-CoA synthetase; Validated

Pssm-ID: 235624 [Multi-domain] Cd Length: 578 Bit Score: 67.27 E-value: 1.24e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  520 AGLTPDAPALLFGE---------ERLSYAELNALANRLAWRLREEGVGSDVLVgIALERGVPMVVALLAVLKAGGAYVPL 590
Cdd:PRK05850    11 ASLQPDDAAFTFIDyeqdpagvaETLTWSQLYRRTLNVAEELRRHGSTGDRAV-ILAPQGLEYIVAFLGALQAGLIAVPL 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  591 D-PQYPA--DRLQYMIDDSGLRLLLSQQSV---LARLPQSDGLQS----LLLD--DLERlvhgyPAENPDLPEAPDSLCY 658
Cdd:PRK05850    90 SvPQGGAhdERVSAVLRDTSPSVVLTTSAVvddVTEYVAPQPGQSappvIEVDllDLDS-----PRGSDARPRDLPSTAY 164

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  659 AIYTSGSTGQPKGVMVRHRALT-NFVCSIA---RQPGMLARDRLLSVTTFSF--DIfGLELYV--PLARGASMLLASreq 730
Cdd:PRK05850   165 LQYTSGSTRTPAGVMVSHRNVIaNFEQLMSdyfGDTGGVPPPDTTVVSWLPFyhDM-GLVLGVcaPILGGCPAVLTS--- 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  731 aqdPEALLdlvERqgvtvlqatPATW-RMLC------------------------DSERVDLLRGCTLLCGGE----ALA 781
Cdd:PRK05850   241 ---PVAFL---QR---------PARWmQLLAsnphafsaapnfafelavrktsddDMAGLDLGGVLGIISGSErvhpATL 305

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  782 EDLAARMrglsaSTWNL--------YGPTETTIWSARFRLGE-----------------EARPFLGG-PL------ENTA 829
Cdd:PRK05850   306 KRFADRF-----APFNLretairpsYGLAEATVYVATREPGQppesvrfdyeklsaghaKRCETGGGtPLvsygspRSPT 380

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  830 LYILDSEMN-PCPPGVAGELLIGGDGLARGYHRRPGLTAERF-----LPDPFAADGSRLyRTGDLArYRADGVIEYLGRI 903
Cdd:PRK05850   381 VRIVDPDTCiECPAGTVGEIWVHGDNVAAGYWQKPEETERTFgatlvDPSPGTPEGPWL-RTGDLG-FISEGELFIVGRI 458


                   ....*...
gi 2183974163  904 DHQVKIRG 911
Cdd:PRK05850   459 KDLLIVDG 466

PLN02479

acetate-CoA ligase

1573-2073

1.26e-10

acetate-CoA ligase

Pssm-ID: 178097 [Multi-domain] Cd Length: 567 Bit Score: 67.18 E-value: 1.26e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1573 LIERQAAERPRATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRY 1652
Cdd:PLN02479    25 FLERAAVVHPTRKSVVHGSVRYTWAQTYQRCRRLASALAKRSIGPGSTVAVIAPNIPAMYEAHFGVPMAGAVVNCVNIRL 104

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1653 PSDRLGYMIEDSGIRLLLTQRaarERLPLGEGL-------------PCLLL----------------------------- 1690
Cdd:PLN02479   105 NAPTIAFLLEHSKSEVVMVDQ---EFFTLAEEAlkilaekkkssfkPPLLIvigdptcdpkslqyalgkgaieyekflet 181

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1691 -DAEHEWAGyPESDPQS-AVGvdnlayviYTSGSTGKPKGTLLPH-GNVLRLFDATRHW-FGFSADDAWSL--FHSYAFD 1764
Cdd:PLN02479   182 gDPEFAWKP-PADEWQSiALG--------YTSGTTASPKGVVLHHrGAYLMALSNALIWgMNEGAVYLWTLpmFHCNGWC 252

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1765 FSvWEIfgALLHGGRLVIVPYETsrspEDFLRLLCRERVTVLNQTPSAFKQLMQvACAGQEVPPLA-LRHVVFGGEALEV 1843
Cdd:PLN02479   253 FT-WTL--AALCGTNICLRQVTA----KAIYSAIANYGVTHFCAAPVVLNTIVN-APKSETILPLPrVVHVMTAGAAPPP 324

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1844 QALrpwfERFGDRAPRLVNMYGITETtvhvtYRPLSLAdldggAASPIGEPIPDLSWYLLDA----------GLN----- 1908
Cdd:PLN02479   325 SVL----FAMSEKGFRVTHTYGLSET-----YGPSTVC-----AWKPEWDSLPPEEQARLNArqgvryigleGLDvvdtk 390

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1909 ---PVPR--GCIGELYVGGAGLARGYLNRPELSCTRFvadpfsttGGRLYRTGDLARYRCDGVVEYVGRIDHQVKIRGFR 1983
Cdd:PLN02479   391 tmkPVPAdgKTMGEIVMRGNMVMKGYLKNPKANEEAF--------ANGWFHSGDLGVKHPDGYIEIKDRSKDIIISGGEN 462

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1984 IELGEIEARLLAQPGVAEAVVL--PHEGPGATQlVGYVVTQ--AAPSDPAALRDTLRQALKASLPEHMVPAHLLFlERLP 2059
Cdd:PLN02479   463 ISSLEVENVVYTHPAVLEASVVarPDERWGESP-CAFVTLKpgVDKSDEAALAEDIMKFCRERLPAYWVPKSVVF-GPLP 540

                          570
                   ....*....|....
gi 2183974163 2060 LTANGKLDRRALPA 2073
Cdd:PLN02479   541 KTATGKIQKHVLRA 554

beta-lac_NRPS

Condensation domain of nonribosomal peptide synthetases (NRPSs) similar to Nocardia uniformis ...

2174-2477

1.96e-10

Pssm-ID: 380469 [Multi-domain] Cd Length: 422 Bit Score: 65.80 E-value: 1.96e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2174 PLLPIQQ--MFFELDIPRRQ-HWNQSVLLEPGqALDGTLLETALQALLAHHDALRLGFRLEDgtwRAEHRAVEAGEV--- 2247
Cdd:cd19547      3 PLAPMQEgmLFRGLFWPDSDaYFNQNVLELVG-GTDEDVLREAWRRVADRYEILRTGFTWRD---RAEPLQYVRDDLapp 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2248 ---LLWQQSVADGQA--LEAL-AEQVQRSLDLGSGPLLRALLATLGDGSQRLLLVIHHLVVDGVSWRILLEDLQTAYRQL 2321
Cdd:cd19547     79 walLDWSGEDPDRRAelLERLlADDRAAGLSLADCPLYRLTLVRLGGGRHYLLWSHHHILLDGWCLSLIWGDVFRVYEEL 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2322 QAGQAVALpAKTSAFKAWAERLQAHARDGGlEGERgYWLAQLEGVS----TELPCdDREGA-QSVRHvrsartELTEEAT 2396
Cdd:cd19547    159 AHGREPQL-SPCRPYRDYVRWIRARTAQSE-ESER-FWREYLRDLTpspfSTAPA-DREGEfDTVVH------EFPEQLT 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2397 rRLLQEAPAAYRTQVNDLLLTALARVIGRWTGQADTLIQLEGHGREELFEDIDLtrTVGWFTSLFPL--RLSP---VAEL 2471
Cdd:cd19547    229 -RLVNEAARGYGVTTNAISQAAWSMLLALQTGARDVVHGLTIAGRPPELEGSEH--MVGIFINTIPLriRLDPdqtVTGL 305


                   ....*.
gi 2183974163 2472 GASIKR 2477
Cdd:cd19547    306 LETIHR 311

PLN02860

o-succinylbenzoate-CoA ligase

509-1004

2.22e-10

o-succinylbenzoate-CoA ligase

Pssm-ID: 215464 [Multi-domain] Cd Length: 563 Bit Score: 66.36 E-value: 2.22e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  509 GQGVHRLfeaqAGLTPDAPALLFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYV 588
Cdd:PLN02860    10 CQCLTRL----ATLRGNAVVTISGNRRRTGHEFVDGVLSLAAGLLRLGLRNGDVVAIAALNSDLYLEWLLAVACAGGIVA 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  589 PLDPQYPADRLQYMIDDSGLRLLLSQQSV--------LARLPqSDGLQSLLLDDLERLVH--------------GYPAEN 646
Cdd:PLN02860    86 PLNYRWSFEEAKSAMLLVRPVMLVTDETCsswyeelqNDRLP-SLMWQVFLESPSSSVFIflnsflttemlkqrALGTTE 164

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  647 PDLPEAPDSLCYAIYTSGSTGQPKGVMVRHRALTnfVCSIARqpgmlardrlLSVTTFSFDifglELYV---PLAR--GA 721
Cdd:PLN02860   165 LDYAWAPDDAVLICFTSGTTGRPKGVTISHSALI--VQSLAK----------IAIVGYGED----DVYLhtaPLCHigGL 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  722 S----MLLASREQAQDPE----ALLDLVERQGVTVLQATPATWRMLCDSERVDLLRGC-----TLLCGGEALAEDL--AA 786
Cdd:PLN02860   229 SsalaMLMVGACHVLLPKfdakAALQAIKQHNVTSMITVPAMMADLISLTRKSMTWKVfpsvrKILNGGGSLSSRLlpDA 308

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  787 RMRGLSASTWNLYGPTETTIWSARFRLGEEARPFLGGPLENTALYILDSEMNP---C----PPGVagELLIGGDG----- 854
Cdd:PLN02860   309 KKLFPNAKLFSAYGMTEACSSLTFMTLHDPTLESPKQTLQTVNQTKSSSVHQPqgvCvgkpAPHV--ELKIGLDEssrvg 386

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  855 --LARGYHrrpglTAERFLPDPFAADGSRL----YRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDS 928
Cdd:PLN02860   387 riLTRGPH-----VMLGYWGQNSETASVLSndgwLDTGDIGWIDKAGNLWLIGRSNDRIKTGGENVYPEEVEAVLSQHPG 461

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  929 VREAVVVAQPGVAGPTLVAYLVP-------TEAALVDAESARQ---QELR--SALKNsllavLPDYMVPAHMLLLEN-LP 995
Cdd:PLN02860   462 VASVVVVGVPDSRLTEMVVACVRlrdgwiwSDNEKENAKKNLTlssETLRhhCREKN-----LSRFKIPKLFVQWRKpFP 536


                   ....*....
gi 2183974163  996 LTPNGKINR 1004
Cdd:PLN02860   537 LTTTGKIRR 545

PLN02387

long-chain-fatty-acid-CoA ligase family protein

598-1009

2.90e-10

long-chain-fatty-acid-CoA ligase family protein

Pssm-ID: 215217 [Multi-domain] Cd Length: 696 Bit Score: 66.29 E-value: 2.90e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  598 RLQYMiDDSGLRLLLSqqsvlarLPQSDGLQSLLLDDLERLVHGYPAEnPDLPeAPDSLCYAIYTSGSTGQPKGVMVRHR 677
Cdd:PLN02387   204 RVIYM-DDEGVDSDSS-------LSGSSNWTVSSFSEVEKLGKENPVD-PDLP-SPNDIAVIMYTSGSTGLPKGVMMTHG 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  678 altNFVCSIARQ----PGMLARDRLLSvttfsfdifglelYVPLA----------------------------------R 719
Cdd:PLN02387   274 ---NIVATVAGVmtvvPKLGKNDVYLA-------------YLPLAhilelaaesvmaavgaaigygspltltdtsnkikK 337

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  720 G----ASMLLASREQAQdpEALLDLVeRQGV--TV------------------LQATPATW-------RMLCDSE----- 763
Cdd:PLN02387   338 GtkgdASALKPTLMTAV--PAILDRV-RDGVrkKVdakgglakklfdiaykrrLAAIEGSWfgawgleKLLWDALvfkki 414

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  764 RVDL---LRGctLLCGGEALAEDLAARMR-GLSASTWNLYGPTETTIWSARFRLGEEARPFLGGPLENTALYILDSEM-- 837
Cdd:PLN02387   415 RAVLggrIRF--MLSGGAPLSGDTQRFINiCLGAPIGQGYGLTETCAGATFSEWDDTSVGRVGPPLPCCYVKLVSWEEgg 492

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  838 -----NPCPpgvAGELLIGGDGLARGYHRRPGLTAERFLPDpfaADGSRLYRTGDLARYRADGVIEYLGRIDHQVKIR-G 911
Cdd:PLN02387   493 ylisdKPMP---RGEIVIGGPSVTLGYFKNQEKTDEVYKVD---ERGMRWFYTGDIGQFHPDGCLEIIDRKKDIVKLQhG 566

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  912 FRIELGEIETRLLEQDSVREAVVVAQPgvAGPTLVAYLVPTEAA-----------------LVDAESARQQELRSALKNS 974
Cdd:PLN02387   567 EYVSLGKVEAALSVSPYVDNIMVHADP--FHSYCVALVVPSQQAlekwakkagidysnfaeLCEKEEAVKEVQQSLSKAA 644

                          490       500       510
                   ....*....|....*....|....*....|....*
gi 2183974163  975 LLAVLPDYMVPAHMLLLENlPLTPNGKINRKALPL 1009
Cdd:PLN02387   645 KAARLEKFEIPAKIKLLPE-PWTPESGLVTAALKL 678

PTZ00237

acetyl-CoA synthetase; Provisional

658-1007

4.26e-10

acetyl-CoA synthetase; Provisional

Pssm-ID: 240325 [Multi-domain] Cd Length: 647 Bit Score: 65.53 E-value: 4.26e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  658 YAIYTSGSTGQPKGVmVRHRAlTNFVCSIARQPGMLARD---RLLSVTTFSFDIFGLELYVPLARGASMLLASREQAQDP 734
Cdd:PTZ00237   258 YILYTSGTTGNSKAV-VRSNG-PHLVGLKYYWRSIIEKDiptVVFSHSSIGWVSFHGFLYGSLSLGNTFVMFEGGIIKNK 335

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  735 EALLDL---VERQGVTVLQATPATWRMLC----DSERV----DLLRGCTLLCGGEALAEDLAARMRG-LSASTWNLYGPT 802
Cdd:PTZ00237   336 HIEDDLwntIEKHKVTHTLTLPKTIRYLIktdpEATIIrskyDLSNLKEIWCGGEVIEESIPEYIENkLKIKSSRGYGQT 415

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  803 ETTIWSArFRLGEEARPF--LGGPLENTALYILDS---EMN-----------PCPPGVAGELLIGGDGLARGYHRRPGLt 866
Cdd:PTZ00237   416 EIGITYL-YCYGHINIPYnaTGVPSIFIKPSILSEdgkELNvneigevafklPMPPSFATTFYKNDEKFKQLFSKFPGY- 493

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  867 aerflpdpfaadgsrlYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVaqpGVAGPTL- 945
Cdd:PTZ00237   494 ----------------YNSGDLGFKDENGYYTIVSRSDDQIKISGNKVQLNTIETSILKHPLVLECCSI---GIYDPDCy 554

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2183974163  946 ---VAYLVpteaaLVDAESARQQELrSALKNSLLAVLPD----YMVPAHMLLLENLPLTPNGKINRKAL 1007
Cdd:PTZ00237   555 nvpIGLLV-----LKQDQSNQSIDL-NKLKNEINNIITQdiesLAVLRKIIIVNQLPKTKTGKIPRQII 617

PLN02479

acetate-CoA ligase

661-1007

4.71e-10

acetate-CoA ligase

Pssm-ID: 178097 [Multi-domain] Cd Length: 567 Bit Score: 65.25 E-value: 4.71e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  661 YTSGSTGQPKGVMVRHRALTNFVCSIARQPGM-LARDRLLSVTTFSFDIFGLELYVPLARGASMLLASREQaqdpEALLD 739
Cdd:PLN02479   202 YTSGTTASPKGVVLHHRGAYLMALSNALIWGMnEGAVYLWTLPMFHCNGWCFTWTLAALCGTNICLRQVTA----KAIYS 277

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  740 LVERQGVTVLQATPATWRMLCDSERVD----LLRGCTLLCGGEALAEDLAARM--RGLSAS-TWNL---YGPTETTIWSA 809
Cdd:PLN02479   278 AIANYGVTHFCAAPVVLNTIVNAPKSEtilpLPRVVHVMTAGAAPPPSVLFAMseKGFRVThTYGLsetYGPSTVCAWKP 357

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  810 ---RFRLGEEARPFLGGPLENTALYILD----SEMNPCPP--GVAGELLIGGDGLARGYHRRPGLTAERFlpdpfaADGs 880
Cdd:PLN02479   358 ewdSLPPEEQARLNARQGVRYIGLEGLDvvdtKTMKPVPAdgKTMGEIVMRGNMVMKGYLKNPKANEEAF------ANG- 430

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  881 rLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQPGVA-GPTLVAYLVPTEAALVDA 959
Cdd:PLN02479   431 -WFHSGDLGVKHPDGYIEIKDRSKDIIISGGENISSLEVENVVYTHPAVLEASVVARPDERwGESPCAFVTLKPGVDKSD 509

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*...
gi 2183974163  960 ESARQQELRSALKNSllavLPDYMVPAHmLLLENLPLTPNGKINRKAL 1007
Cdd:PLN02479   510 EAALAEDIMKFCRER----LPAYWVPKS-VVFGPLPKTATGKIQKHVL 552

PRK08162

acyl-CoA synthetase; Validated

1561-2071

6.61e-10

acyl-CoA synthetase; Validated

Pssm-ID: 236169 [Multi-domain] Cd Length: 545 Bit Score: 64.58 E-value: 6.61e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1561 PQDFTPASCLhRLIERQAAERPRATAVVYGERALDYGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILK 1640
Cdd:PRK08162    12 AANYVPLTPL-SFLERAAEVYPDRPAVIHGDRRRTWAETYARCRRLASALARRGIGRGDTVAVLLPNIPAMVEAHFGVPM 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1641 AGGAYVPLDPRYPSDRLGYMIEDSGIRLLLTQRA----ARERLPLGEGLPCLLLDAEHewAGYPESDPQSAV-------- 1708
Cdd:PRK08162    91 AGAVLNTLNTRLDAASIAFMLRHGEAKVLIVDTEfaevAREALALLPGPKPLVIDVDD--PEYPGGRFIGALdyeaflas 168

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1709 GVDNLAYVI-----------YTSGSTGKPKGTLLPH--------GNVLRlFDATRHwfgfsADDAWSL--FHSYAFDFSv 1767
Cdd:PRK08162   169 GDPDFAWTLpadewdaialnYTSGTTGNPKGVVYHHrgaylnalSNILA-WGMPKH-----PVYLWTLpmFHCNGWCFP- 241

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1768 WEIfgALLHGgrlVIVPYETSRsPEDFLRLLCRERVT-------VLN---QTPSAFK----QLMQVACAGQeVPPLAlrh 1833
Cdd:PRK08162   242 WTV--AARAG---TNVCLRKVD-PKLIFDLIREHGVThycgapiVLSaliNAPAEWRagidHPVHAMVAGA-APPAA--- 311

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1834 VVFGGEALEVqalrpwferfgdrapRLVNMYGITEttvhvTYRPLSL-ADLDGGAASPIGEPIPDLSW----YLLDAGLN 1908
Cdd:PRK08162   312 VIAKMEEIGF---------------DLTHVYGLTE-----TYGPATVcAWQPEWDALPLDERAQLKARqgvrYPLQEGVT 371

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1909 --------PVPRG--CIGELYVGGAGLARGYLNRPELSCTRFvadpfstTGGrLYRTGDLARYRCDGvveYVgridhQVK 1978
Cdd:PRK08162   372 vldpdtmqPVPADgeTIGEIMFRGNIVMKGYLKNPKATEEAF-------AGG-WFHTGDLAVLHPDG---YI-----KIK 435

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1979 IR--------GFRIELGEIEARLLAQPGVAEA--VVLPHEGPGATQLVGYVVTQAAPSDPAALRDTLRQalkaSLPEHMV 2048
Cdd:PRK08162   436 DRskdiiisgGENISSIEVEDVLYRHPAVLVAavVAKPDPKWGEVPCAFVELKDGASATEEEIIAHCRE----HLAGFKV 511

                          570       580
                   ....*....|....*....|...
gi 2183974163 2049 PAHLLFLErLPLTANGKLDRRAL 2071
Cdd:PRK08162   512 PKAVVFGE-LPKTSTGKIQKFVL 533

FCS

cd05921

Feruloyl-CoA synthetase (FCS); Feruloyl-CoA synthetase is an essential enzyme in the feruloyl ...

535-977

8.54e-10

Pssm-ID: 341245 [Multi-domain] Cd Length: 561 Bit Score: 64.38 E-value: 8.54e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  535 RLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPA-----DRLQYMIDdsglr 609
Cdd:cd05921     25 RVTYAEALRQVRAIAQGLLDLGLSAERPLLILSGNSIEHALMALAAMYAGVPAAPVSPAYSLmsqdlAKLKHLFE----- 99

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  610 lLLSQQSVLAR--LPQSDGLQSLLLDDLERLVHGYPAENP---------------DLPEA-----PDSLCYAIYTSGSTG 667
Cdd:cd05921    100 -LLKPGLVFAQdaAPFARALAAIFPLGTPLVVSRNAVAGRgaisfaelaatpptaAVDAAfaavgPDTVAKFLFTSGSTG 178

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  668 QPKGVMVRHRALTNFVCSIARQPGMLARDRLLSVT------TFSFD-IFGLELYvplaRGASMLL-ASREQAQDPEALLD 739
Cdd:cd05921    179 LPKAVINTQRMLCANQAMLEQTYPFFGEEPPVLVDwlpwnhTFGGNhNFNLVLY----NGGTLYIdDGKPMPGGFEETLR 254

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  740 LVERQGVTVLQATPATWRMLcdserVDLLRGCTLLC------------GGEALAEDLAARMRGLSAST-------WNLYG 800
Cdd:cd05921    255 NLREISPTVYFNVPAGWEML-----VAALEKDEALRrrffkrlklmfyAGAGLSQDVWDRLQALAVATvgeripmMAGLG 329

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  801 PTETTIwSARFRLGEEARP-FLGGPLENTALYILdsemnpcPPGVAGELLIGGDGLARGYHRRPGLTAERFLPDPFaadg 879
Cdd:cd05921    330 ATETAP-TATFTHWPTERSgLIGLPAPGTELKLV-------PSGGKYEVRVKGPNVTPGYWRQPELTAQAFDEEGF---- 397

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  880 srlYRTGDLARYrAD------GVIeYLGRIDHQVKIR-GFRIELGEIETRLLEQDS--VREAVVVAQPG-------VAGP 943
Cdd:cd05921    398 ---YCLGDAAKL-ADpddpakGLV-FDGRVAEDFKLAsGTWVSVGPLRARAVAACAplVHDAVVAGEDRaevgalvFPDL 472

                          490       500       510
                   ....*....|....*....|....*....|....
gi 2183974163  944 TLVAYLVPTEAAlVDAESARQQELRSALKNSLLA 977
Cdd:cd05921    473 LACRRLVGLQEA-SDAEVLRHAKVRAAFRDRLAA 505

PaaK

COG1541

Phenylacetate-coenzyme A ligase PaaK, adenylate-forming domain family [Coenzyme transport and ...

1707-2043

8.60e-10

Phenylacetate-coenzyme A ligase PaaK, adenylate-forming domain family [Coenzyme transport and metabolism];

Pssm-ID: 441150 [Multi-domain] Cd Length: 423 Bit Score: 64.01 E-value: 8.60e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1707 AVGVDNLAYVIYTSGSTGKPKGTLL-------PHGNVLRLFdatrHWFGFSADDAwsLFHSYAFDFSVWeifGALLHGG- 1778
Cdd:COG1541     79 AVPLEEIVRIHASSGTTGKPTVVGYtrkdldrWAELFARSL----RAAGVRPGDR--VQNAFGYGLFTG---GLGLHYGa 149

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1779 -RL--VIVPYeTSRSPEDFLRLLCRERVTVLNQTPSAFKQLMQVACA-GQEVPPLALRHVVFGGEALeVQALRPWFE-RF 1853
Cdd:COG1541    150 eRLgaTVIPA-GGGNTERQLRLMQDFGPTVLVGTPSYLLYLAEVAEEeGIDPRDLSLKKGIFGGEPW-SEEMRKEIEeRW 227

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1854 GDRAprlVNMYGITETTVHVTYrplSLADLDGGAaspIGEP--IPDlswyLLD-AGLNPVPRGCIGELYVggaglargyl 1930
Cdd:COG1541    228 GIKA---YDIYGLTEVGPGVAY---ECEAQDGLH---IWEDhfLVE----IIDpETGEPVPEGEEGELVV---------- 284

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1931 nrpelsctrfvadpfsTTGGR----L--YRTGDLARY------------RCDGVveyVGRIDHQVKIRGFRIELGEIEAR 1992
Cdd:COG1541    285 ----------------TTLTKeampLirYRTGDLTRLlpepcpcgrthpRIGRI---LGRADDMLIIRGVNVFPSQIEEV 345

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2183974163 1993 LLAQPGVAEA--VVLPHEGPGATQLVgyVVTQAAPSDPAALRDTLRQALKASL 2043
Cdd:COG1541    346 LLRIPEVGPEyqIVVDREGGLDELTV--RVELAPGASLEALAEAIAAALKAVL 396

A_NRPS_acs4

cd17654

acyl-CoA synthetase family member 4; This family of the adenylation (A) domain of nonribosomal ...

3099-3183

1.01e-09

Pssm-ID: 341309 [Multi-domain] Cd Length: 449 Bit Score: 64.03 E-value: 1.01e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3099 PTAPALAFGEERLD----YAELNRRANRLAHALIERGIGADRLVGVAMERSIEMVVALMAILKAGGAYVPVDPEYPEERQ 3174
Cdd:cd17654      1 PDRPALIIDQTTSDttvsYADLAEKISNLSNFLRKKFQTEERAIGLRCDRGTESPVAILAILFLGAAYAPIDPASPEQRS 80


                   ....*....
gi 2183974163 3175 AYMLEDSGV 3183
Cdd:cd17654     81 LTVMKKCHV 89

PRK06334

long chain fatty acid--[acyl-carrier-protein] ligase; Validated

1706-2073

1.02e-09

long chain fatty acid--[acyl-carrier-protein] ligase; Validated

Pssm-ID: 180533 [Multi-domain] Cd Length: 539 Bit Score: 64.07 E-value: 1.02e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1706 SAVGVDNLAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRHWFGFSADDAW----SLFHSYAFDFSVweIFGALlhGGRLV 1781
Cdd:PRK06334   178 SDKDPEDVAVILFTSGTEKLPKGVPLTHANLLANQRACLKFFSPKEDDVMmsflPPFHAYGFNSCT--LFPLL--SGVPV 253

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1782 IVPYeTSRSPEDFLRLLCRERVTVLNQTPSAFKQLMQVAcAGQEVPPLALRHVVFGGEALEvQALRPWFER-FGDRAPRl 1860
Cdd:PRK06334   254 VFAY-NPLYPKKIVEMIDEAKVTFLGSTPVFFDYILKTA-KKQESCLPSLRFVVIGGDAFK-DSLYQEALKtFPHIQLR- 329

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1861 vNMYGITETTVHVTYRPLSladldggaaSP-----IGEPIPDLSWYLLDAGLN-PVPRGCIGELYVGGAGLARGYLNrpe 1934
Cdd:PRK06334   330 -QGYGTTECSPVITINTVN---------SPkhescVGMPIRGMDVLIVSEETKvPVSSGETGLVLTRGTSLFSGYLG--- 396

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1935 lsctrfvADP---FSTTGGRL-YRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAvvlPHEGP 2010
Cdd:PRK06334   397 -------EDFgqgFVELGGETwYVTGDLGYVDRHGELFLKGRLSRFVKIGAEMVSLEALESILMEGFGQNAA---DHAGP 466

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2183974163 2011 GAT-----QLVGYVVTQAAPSDPAALRDTLRQALKASLpehMVPAHLLFLERLPLTANGKLDRRALPA 2073
Cdd:PRK06334   467 LVVcglpgEKVRLCLFTTFPTSISEVNDILKNSKTSSI---LKISYHHQVESIPMLGTGKPDYCSLNA 531

Acs

COG0365

Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase [Lipid transport and metabolism];

3088-3182

1.37e-09

Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase [Lipid transport and metabolism];

Pssm-ID: 440134 [Multi-domain] Cd Length: 565 Bit Score: 63.59 E-value: 1.37e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3088 HRLFEEQVERTPTAPALAF----GEER-LDYAELNRRANRLAHALIERGIGA-DRlVGVAMERSIEMVVALMAILKAGGA 3161
Cdd:COG0365     12 YNCLDRHAEGRGDKVALIWegedGEERtLTYAELRREVNRFANALRALGVKKgDR-VAIYLPNIPEAVIAMLACARIGAV 90

                           90       100
                   ....*....|....*....|.
gi 2183974163 3162 YVPVDPEYPEERQAYMLEDSG 3182
Cdd:COG0365     91 HSPVFPGFGAEALADRIEDAE 111

PRK07824

o-succinylbenzoate--CoA ligase;

662-1007

1.39e-09

o-succinylbenzoate--CoA ligase;

Pssm-ID: 236108 [Multi-domain] Cd Length: 358 Bit Score: 62.76 E-value: 1.39e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  662 TSGSTGQPKGVMVRHRALTNFVCSIARQPGMLARdRLLSVTTFSfdIFGLELYV-PLARGASMLLASREQAQDPEALLDL 740
Cdd:PRK07824    43 TSGTTGTPKGAMLTAAALTASADATHDRLGGPGQ-WLLALPAHH--IAGLQVLVrSVIAGSEPVELDVSAGFDPTALPRA 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  741 VERQG-------VTVLQATPAtwrmLCDSERVDLLRGC-TLLCGGEALAEDLAARMRGLSASTWNLYGPTETTiwsarfr 812
Cdd:PRK07824   120 VAELGggrrytsLVPMQLAKA----LDDPAATAALAELdAVLVGGGPAPAPVLDAAAAAGINVVRTYGMSETS------- 188

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  813 lgeearpflGG------PLENTALYILDsemnpcppgvaGELLIGGDGLARGYHRRPGltaerflPDPFAADGsrLYRTG 886
Cdd:PRK07824   189 ---------GGcvydgvPLDGVRVRVED-----------GRIALGGPTLAKGYRNPVD-------PDPFAEPG--WFRTD 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  887 DLARYrADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVaqpGVAGPTLVAYLVpteAALVDAESARqqE 966
Cdd:PRK07824   240 DLGAL-DDGVLTVLGRADDAISTGGLTVLPQVVEAALATHPAVADCAVF---GLPDDRLGQRVV---AAVVGDGGPA--P 310

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|.
gi 2183974163  967 LRSALKNSLLAVLPDYMVPAHMLLLENLPLTPNGKINRKAL 1007
Cdd:PRK07824   311 TLEALRAHVARTLDRTAAPRELHVVDELPRRGIGKVDRRAL 351

AMP-binding_C

pfam13193

AMP-binding enzyme C-terminal domain; This is a small domain that is found C terminal to ...

918-1001

1.40e-09

AMP-binding enzyme C-terminal domain; This is a small domain that is found C terminal to pfam00501. It has a central beta sheet core that is flanked by alpha helices.

Pssm-ID: 463804 [Multi-domain] Cd Length: 76 Bit Score: 56.78 E-value: 1.40e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  918 EIETRLLEQDSVREAVVVAQPG-VAGPTLVAYLVPTEAALVDAEsarqqELRSALKnsllAVLPDYMVPAHMLLLENLPL 996
Cdd:pfam13193    1 EVESALVSHPAVAEAAVVGVPDeLKGEAPVAFVVLKPGVELLEE-----ELVAHVR----EELGPYAVPKEVVFVDELPK 71


                   ....*
gi 2183974163  997 TPNGK 1001
Cdd:pfam13193   72 TRSGK 76

PRK08316

acyl-CoA synthetase; Validated

3095-3183

2.11e-09

acyl-CoA synthetase; Validated

Pssm-ID: 181381 [Multi-domain] Cd Length: 523 Bit Score: 63.03 E-value: 2.11e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3095 VERTPTAPALAFGEERLDYAELNRRANRLAHALIERGIGA-DRLVGVAmERSIEMVVALMAILKAGGAYVPVDPEYPEER 3173
Cdd:PRK08316    21 ARRYPDKTALVFGDRSWTYAELDAAVNRVAAALLDLGLKKgDRVAALG-HNSDAYALLWLACARAGAVHVPVNFMLTGEE 99

                           90
                   ....*....|
gi 2183974163 3174 QAYMLEDSGV 3183
Cdd:PRK08316   100 LAYILDHSGA 109

PRK08308

acyl-CoA synthetase; Validated

879-1014

2.31e-09

acyl-CoA synthetase; Validated

Pssm-ID: 236231 [Multi-domain] Cd Length: 414 Bit Score: 62.36 E-value: 2.31e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  879 GSRLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVAQP-GVAGpTLVAYLVPTEAAlV 957
Cdd:PRK08308   289 GDKEIFTKDLGYKSERGTLHFMGRMDDVINVSGLNVYPIEVEDVMLRLPGVQEAVVYRGKdPVAG-ERVKAKVISHEE-I 366

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2183974163  958 DAESARQQelrsALKNsllavLPDYMVPAHMLLLENLPLTPNGKINRKALPLPDASA 1014
Cdd:PRK08308   367 DPVQLREW----CIQH-----LAPYQVPHEIESVTEIPKNANGKVSRKLLELGEVTA 414

PRK00174

acetyl-CoA synthetase; Provisional

832-1007

3.90e-09

acetyl-CoA synthetase; Provisional

Pssm-ID: 234677 [Multi-domain] Cd Length: 637 Bit Score: 62.47 E-value: 3.90e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  832 ILDSEMNPCPPGVAGELLIGGD--GLARGYHRRPgltaERFLPDPFAADGSRlYRTGDLARYRADGVIEYLGRIDHQVKI 909
Cdd:PRK00174   437 VVDEEGNPLEGGEGGNLVIKDPwpGMMRTIYGDH----ERFVKTYFSTFKGM-YFTGDGARRDEDGYYWITGRVDDVLNV 511

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  910 RGFRIELGEIETRLLEQDSVREAVVVAQP-GVAGPTLVAYLVPTEAALVDAesarqqELRSALKNSLLAVLPDYMVPAHM 988
Cdd:PRK00174   512 SGHRLGTAEIESALVAHPKVAEAAVVGRPdDIKGQGIYAFVTLKGGEEPSD------ELRKELRNWVRKEIGPIAKPDVI 585

                          170
                   ....*....|....*....
gi 2183974163  989 LLLENLPLTPNGKINRKAL 1007
Cdd:PRK00174   586 QFAPGLPKTRSGKIMRRIL 604

A_NRPS_alphaAR

cd17647

Alpha-aminoadipate reductase; This family contains L-2-aminoadipate reductase, also known as ...

3113-3174

5.66e-09

Pssm-ID: 341302 [Multi-domain] Cd Length: 520 Bit Score: 61.76 E-value: 5.66e-09

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2183974163 3113 YAELNRRANRLAHALIERGIGADRLVGVAMERSIEMVVALMAILKAGGAYVPVDPEYPEERQ 3174
Cdd:cd17647     23 YRDINEASNIVAHYLIKTGIKRGDVVMIYSYRGVDLMVAVMGVLKAGATFSVIDPAYPPARQ 84

FACL_fum10p_like

cd05926

Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; FACL ...

3099-3182

5.67e-09

Pssm-ID: 341249 [Multi-domain] Cd Length: 493 Bit Score: 61.56 E-value: 5.67e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3099 PTAPALAFGEERLD--YAELNRRANRLAHALIERGIGADRLVGVAMERSIEMVVALMAILKAGGAYVPVDPEYPEERQAY 3176
Cdd:cd05926      1 PDAPALVVPGSTPAltYADLAELVDDLARQLAALGIKKGDRVAIALPNGLEFVVAFLAAARAGAVVAPLNPAYKKAEFEF 80


                   ....*.
gi 2183974163 3177 MLEDSG 3182
Cdd:cd05926     81 YLADLG 86

PLN02387

long-chain-fatty-acid-CoA ligase family protein

1711-2029

5.98e-09

long-chain-fatty-acid-CoA ligase family protein

Pssm-ID: 215217 [Multi-domain] Cd Length: 696 Bit Score: 62.06 E-value: 5.98e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1711 DNLAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRHWF-GFSADDAW----SLFH--SYAFDFSVWEIFGALLHGGRLVIV 1783
Cdd:PLN02387   250 NDIAVIMYTSGSTGLPKGVMMTHGNIVATVAGVMTVVpKLGKNDVYlaylPLAHilELAAESVMAAVGAAIGYGSPLTLT 329

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1784 pyETS-------RSPEDFLR---------LLCRERVTVLNQTPS---AFKQLMQVACAGQEVpplALRHVVFGGEALE-- 1842
Cdd:PLN02387   330 --DTSnkikkgtKGDASALKptlmtavpaILDRVRDGVRKKVDAkggLAKKLFDIAYKRRLA---AIEGSWFGAWGLEkl 404

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1843 ---VQALRPWFERFGDR--------AP------RLVNM---------YGITETTVHVTYrplslADLDGGAASPIGEPIP 1896
Cdd:PLN02387   405 lwdALVFKKIRAVLGGRirfmlsggAPlsgdtqRFINIclgapigqgYGLTETCAGATF-----SEWDDTSVGRVGPPLP 479

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1897 D-----LSW----YLL-DAglnPVPRGcigELYVGGAGLARGYLNRPELSCTRFVADpfsTTGGRLYRTGDLARYRCDGV 1966
Cdd:PLN02387   480 CcyvklVSWeeggYLIsDK---PMPRG---EIVIGGPSVTLGYFKNQEKTDEVYKVD---ERGMRWFYTGDIGQFHPDGC 550

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2183974163 1967 VEYVGRIDHQVKIR-GFRIELGEIEARLLAQPGVAEAVVlpHEGPGATQLVGYVVtqaaPSDPA 2029
Cdd:PLN02387   551 LEIIDRKKDIVKLQhGEYVSLGKVEAALSVSPYVDNIMV--HADPFHSYCVALVV----PSQQA 608

LC_FACS_bac1

cd17641

bacterial long-chain fatty acid CoA synthetase; The members of this family are bacterial ...

537-935

1.89e-08

bacterial long-chain fatty acid CoA synthetase; The members of this family are bacterial long-chain fatty acid CoA synthetase, most of which are as yet uncharacterized. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.

Pssm-ID: 341296 [Multi-domain] Cd Length: 569 Bit Score: 60.13 E-value: 1.89e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  537 SYAELNALANRLAWRLREEGVGSDVLVGIaLERGVP-MVVALLAVLKAGGAYVPLDPQYPADRLQYMIDDSGLRLLLS-- 613
Cdd:cd17641     13 TWADYADRVRAFALGLLALGVGRGDVVAI-LGDNRPeWVWAELAAQAIGALSLGIYQDSMAEEVAYLLNYTGARVVIAed 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  614 QQSVLARLPQSDGLQSLL--------------------LDDLERLVHGYPAENPDLPEA------PDSLCYAIYTSGSTG 667
Cdd:cd17641     92 EEQVDKLLEIADRIPSVRyviycdprgmrkyddprlisFEDVVALGRALDRRDPGLYERevaagkGEDVAVLCTTSGTTG 171

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  668 QPKGVMVRHRALTNFVCSIARQPGMLARDRLLSVTTFSFdiFGLELYVPlarGASMLLASREQ-AQDPEALLDLVERQGV 746
Cdd:cd17641    172 KPKLAMLSHGNFLGHCAAYLAADPLGPGDEYVSVLPLPW--IGEQMYSV---GQALVCGFIVNfPEEPETMMEDLREIGP 246

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  747 TVLQATPATW---------RMLcDSERVD--LLRgctllCGGEALAEDLAARMRGLSASTWN----------LYGPTETT 805
Cdd:cd17641    247 TFVLLPPRVWegiaadvraRMM-DATPFKrfMFE-----LGMKLGLRALDRGKRGRPVSLWLrlaswladalLFRPLRDR 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  806 IWSARFR--------LGEEARPF---LGGPL-------ENTALYIL------DSEMNPCP-PGV------AGELLIGGDG 854
Cdd:cd17641    321 LGFSRLRsaatggaaLGPDTFRFfhaIGVPLkqlygqtELAGAYTVhrdgdvDPDTVGVPfPGTevrideVGEILVRSPG 400

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  855 LARGYHRRPGLTAERFLPDPFaadgsrlYRTGDLARYRADGVIEYLGRI-DHQVKIRGFRIELGEIETRLLEQDSVREAV 933
Cdd:cd17641    401 VFVGYYKNPEATAEDFDEDGW-------LHTGDAGYFKENGHLVVIDRAkDVGTTSDGTRFSPQFIENKLKFSPYIAEAV 473


                   ..
gi 2183974163  934 VV 935
Cdd:cd17641    474 VL 475

LC-FACS_euk

cd05927

Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS); The members of this family are ...

1596-1736

2.59e-08

Pssm-ID: 341250 [Multi-domain] Cd Length: 545 Bit Score: 59.54 E-value: 2.59e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1596 YGELNLRANRLAHRLIELGV--GPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLdprYpsDRLG-----YMIEDSGIRL 1668
Cdd:cd05927      8 YKEVAERADNIGSALRSLGGkpAPASFVGIYSINRPEWIISELACYAYSLVTVPL---Y--DTLGpeaieYILNHAEISI 82

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2183974163 1669 LLTQraarerlplgEGLPCLLL-DAEHEWAGYPESDPQSAVgvDNLAYVIYTSGSTGKPKGTLLPHGNV 1736
Cdd:cd05927     83 VFCD----------AGVKVYSLeEFEKLGKKNKVPPPPPKP--EDLATICYTSGTTGNPKGVMLTHGNI 139

PRK05850

acyl-CoA synthetase; Validated

1594-1981

2.89e-08

acyl-CoA synthetase; Validated

Pssm-ID: 235624 [Multi-domain] Cd Length: 578 Bit Score: 59.57 E-value: 2.89e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1594 LDYGELNLRANRLAHRLIELGVGPDVLVGLAAErSLEMIVGLLAILKAGGAYVPLDPRYPS---DRLGYMIEDSGIRLLL 1670
Cdd:PRK05850    36 LTWSQLYRRTLNVAEELRRHGSTGDRAVILAPQ-GLEYIVAFLGALQAGLIAVPLSVPQGGahdERVSAVLRDTSPSVVL 114

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1671 TQRAARE------RLPLGEGLPCLL------LDAEHEwagyPESDPQSAvgvDNLAYVIYTSGSTGKPKGTLLPHGNVLR 1738
Cdd:PRK05850   115 TTSAVVDdvteyvAPQPGQSAPPVIevdlldLDSPRG----SDARPRDL---PSTAYLQYTSGSTRTPAGVMVSHRNVIA 187

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1739 LFD-ATRHWFGFSADDA--------W-SLFHSYAFdfsVWEIFGALLHGGRLVIVpyetsrSPEDFLrllcrervtvlnQ 1808
Cdd:PRK05850   188 NFEqLMSDYFGDTGGVPppdttvvsWlPFYHDMGL---VLGVCAPILGGCPAVLT------SPVAFL------------Q 246

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1809 TPSAFKQLMQVACAGQEVPP------------------LALRHV---VFGGEALEVQALRPWFERFG-----DRAPRlvN 1862
Cdd:PRK05850   247 RPARWMQLLASNPHAFSAAPnfafelavrktsdddmagLDLGGVlgiISGSERVHPATLKRFADRFApfnlrETAIR--P 324

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1863 MYGITETTVHVTYRPLSLA---------DLDGGAASPIGepiPDLSWYLLDAGL--NPV------------PRGCIGELY 1919
Cdd:PRK05850   325 SYGLAEATVYVATREPGQPpesvrfdyeKLSAGHAKRCE---TGGGTPLVSYGSprSPTvrivdpdtciecPAGTVGEIW 401

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2183974163 1920 VGGAGLARGYLNRPELSCTRF---VADPFS-TTGGRLYRTGDLArYRCDGVVEYVGRIDHQVKIRG 1981
Cdd:PRK05850   402 VHGDNVAAGYWQKPEETERTFgatLVDPSPgTPEGPWLRTGDLG-FISEGELFIVGRIKDLLIVDG 466

PLN02861

long-chain-fatty-acid-CoA ligase

489-958

3.52e-08

long-chain-fatty-acid-CoA ligase

Pssm-ID: 178452 [Multi-domain] Cd Length: 660 Bit Score: 59.47 E-value: 3.52e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  489 AEERATLLQRSRLPASEYPAGQGVHRLFEAQAGLTP-----DAPALLFGEERLSYAELNALANRL---------AWRLRE 554
Cdd:PLN02861     2 AETYTVKVEESRPATGGKPSAGPVYRSIYAKDGLLDlpadiDSPWQFFSDAVKKYPNNQMLGRRQvtdskvgpyVWLTYK 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  555 EGVGSDVLVGIALE-RGV--------------PMVVALLAVLKAGGAYVPLDPQYPADRLQYMIDDSGLRLLLSQ----Q 615
Cdd:PLN02861    82 EVYDAAIRIGSAIRsRGVnpgdrcgiygsncpEWIIAMEACNSQGITYVPLYDTLGANAVEFIINHAEVSIAFVQeskiS 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  616 SVLARLPQSDG----------LQSLLLDDLERL-VHGYPAE--------NPDLP-EAPDSLCYAIYTSGSTGQPKGVMVR 675
Cdd:PLN02861   162 SILSCLPKCSSnlktivsfgdVSSEQKEEAEELgVSCFSWEefslmgslDCELPpKQKTDICTIMYTSGTTGEPKGVILT 241

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  676 HRALTnfvcsiarqPGMLARDRLLSVTT---------FSF----DIFG--LELYVpLARGASM--------LLASREQAQ 732
Cdd:PLN02861   242 NRAII---------AEVLSTDHLLKVTDrvateedsyFSYlplaHVYDqvIETYC-ISKGASIgfwqgdirYLMEDVQAL 311

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  733 DP----------------------------EALLDLVE-------RQGVTVLQATPATWRMLCDSERVDLL-RGCTLLCG 776
Cdd:PLN02861   312 KPtifcgvprvydriytgimqkissggmlrKKLFDFAYnyklgnlRKGLKQEEASPRLDRLVFDKIKEGLGgRVRLLLSG 391

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  777 GEALAEDLAARMRGLSASTWNL-YGPTETTiwSARFRLGEEARPFLG--GPLENTALYILDS--EM-----NPCPpgvAG 846
Cdd:PLN02861   392 AAPLPRHVEEFLRVTSCSVLSQgYGLTESC--GGCFTSIANVFSMVGtvGVPMTTIEARLESvpEMgydalSDVP---RG 466

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  847 ELLIGGDGLARGYHRRPGLTAERFLpdpfaaDGsrLYRTGDLARYRADGVIEYlgrIDHQVKIrgFRIELGE-IETRLLE 925
Cdd:PLN02861   467 EICLRGNTLFSGYHKRQDLTEEVLI------DG--WFHTGDIGEWQPNGAMKI---IDRKKNI--FKLSQGEyVAVENLE 533

                          570       580       590
                   ....*....|....*....|....*....|....*..
gi 2183974163  926 QDSVReAVVVAQPGVAGPT----LVAYLVPTEAALVD 958
Cdd:PLN02861   534 NTYSR-CPLIASIWVYGNSfesfLVAVVVPDRQALED 569

PRK08180

feruloyl-CoA synthase; Reviewed

1547-1961

3.64e-08

feruloyl-CoA synthase; Reviewed

Pssm-ID: 236175 [Multi-domain] Cd Length: 614 Bit Score: 59.12 E-value: 3.64e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1547 EAEARAD--LLQWNPGPQDFTPASCLHRLiERQAAERPRATAVVY-----GERALDYGELNLRANRLAHRLIELGVGPDV 1619
Cdd:PRK08180    17 EVERRADgtIYLRSAEPLGDYPRRLTDRL-VHWAQEAPDRVFLAErgadgGWRRLTYAEALERVRAIAQALLDRGLSAER 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1620 LVGLAAERSLEMIVGLLAILKAGGAYVPLDPRY---PSD--RLGYMIEdsgirlLLT------------QRAARERLPLG 1682
Cdd:PRK08180    96 PLMILSGNSIEHALLALAAMYAGVPYAPVSPAYslvSQDfgKLRHVLE------LLTpglvfaddgaafARALAAVVPAD 169

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1683 ----------EGLPCLLLDAEHEWAGYPESDPQ-SAVGVDNLAYVIYTSGSTGKPKGTLLPHGNVLRLFDATRHWFGFSA 1751
Cdd:PRK08180   170 vevvavrgavPGRAATPFAALLATPPTAAVDAAhAAVGPDTIAKFLFTSGSTGLPKAVINTHRMLCANQQMLAQTFPFLA 249

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1752 DD--------AWSlfHSYAFDFsvweIFG-ALLHGGRLVI-----VP---YETsrspedfLRLLcRE-RVTVLNQTPSAF 1813
Cdd:PRK08180   250 EEppvlvdwlPWN--HTFGGNH----NLGiVLYNGGTLYIddgkpTPggfDET-------LRNL-REiSPTVYFNVPKGW 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1814 KQLmqvacagqeVPPL----ALRHVVF--------GGEALEvQALRPWFERFGDRA----PRLVNMYGITET--TVHVTY 1875
Cdd:PRK08180   316 EML---------VPALerdaALRRRFFsrlkllfyAGAALS-QDVWDRLDRVAEATcgerIRMMTGLGMTETapSATFTT 385

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1876 RPLSLadldggaASPIGEPIPDLSWYLldaglnpVPRGCIGELYVGGAGLARGYLNRPELSCTRFVADPFsttggrlYRT 1955
Cdd:PRK08180   386 GPLSR-------AGNIGLPAPGCEVKL-------VPVGGKLEVRVKGPNVTPGYWRAPELTAEAFDEEGY-------YRS 444


                   ....*.
gi 2183974163 1956 GDLARY 1961
Cdd:PRK08180   445 GDAVRF 450

PRK08314

long-chain-fatty-acid--CoA ligase; Validated

3096-3182

4.68e-08

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 236235 [Multi-domain] Cd Length: 546 Bit Score: 58.82 E-value: 4.68e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3096 ERTPTAPALAFGEERLDYAELNRRANRLAHAL-----IERGigaDRlVGVAMERSIEMVVALMAILKAGGAYVPVDPEYP 3170
Cdd:PRK08314    21 RRYPDKTAIVFYGRAISYRELLEEAERLAGYLqqecgVRKG---DR-VLLYMQNSPQFVIAYYAILRANAVVVPVNPMNR 96

                           90
                   ....*....|..
gi 2183974163 3171 EERQAYMLEDSG 3182
Cdd:PRK08314    97 EEELAHYVTDSG 108

PTZ00237

acetyl-CoA synthetase; Provisional

1715-2068

4.69e-08

acetyl-CoA synthetase; Provisional

Pssm-ID: 240325 [Multi-domain] Cd Length: 647 Bit Score: 58.98 E-value: 4.69e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1715 YVIYTSGSTGKPKGTLLPHGNVLRLFdaTRHWFGFSADD-----------AWSLFHSYafdfsvweIFGALLHGGRLVIv 1783
Cdd:PTZ00237   258 YILYTSGTTGNSKAVVRSNGPHLVGL--KYYWRSIIEKDiptvvfshssiGWVSFHGF--------LYGSLSLGNTFVM- 326

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1784 pYE-----TSRSPEDFLRLLCRERVTVLNQTPSAFKQLMQVACAGQEVPP----LALRHVVFGGEALEvQALRPWFE-RF 1853
Cdd:PTZ00237   327 -FEggiikNKHIEDDLWNTIEKHKVTHTLTLPKTIRYLIKTDPEATIIRSkydlSNLKEIWCGGEVIE-ESIPEYIEnKL 404

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1854 GDRAPRLvnmYGITET--TVHVTYRPLSLAdldggaASPIGEPIPDLSWYLLDAGLNPVPRGCIGELYVGgaglargyLN 1931
Cdd:PTZ00237   405 KIKSSRG---YGQTEIgiTYLYCYGHINIP------YNATGVPSIFIKPSILSEDGKELNVNEIGEVAFK--------LP 467

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1932 RPELSCTRFVADP------FSTTGGrLYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGVAEAVVL 2005
Cdd:PTZ00237   468 MPPSFATTFYKNDekfkqlFSKFPG-YYNSGDLGFKDENGYYTIVSRSDDQIKISGNKVQLNTIETSILKHPLVLECCSI 546

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2183974163 2006 PHEGPG-ATQLVGYVVTQAAPSDPAA----LRDTLRQALKASLPEHMVPAHLLFLERLPLTANGKLDR 2068
Cdd:PTZ00237   547 GIYDPDcYNVPIGLLVLKQDQSNQSIdlnkLKNEINNIITQDIESLAVLRKIIIVNQLPKTKTGKIPR 614

PRK08276

long-chain-fatty-acid--CoA ligase; Validated

3101-3182

4.88e-08

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 236215 [Multi-domain] Cd Length: 502 Bit Score: 58.76 E-value: 4.88e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3101 APALAFGEERLDYAELNRRANRLAHALIERGIGADRLVGVAMERSIEMVVALMAILKAGGAYVPVDPEYPEERQAYMLED 3180
Cdd:PRK08276     2 AVIMAPSGEVVTYGELEARSNRLAHGLRALGLREGDVVAILLENNPEFFEVYWAARRSGLYYTPINWHLTAAEIAYIVDD 81


                   ..
gi 2183974163 3181 SG 3182
Cdd:PRK08276    82 SG 83

Firefly_Luc_like

cd05911

Firefly luciferase of light emitting insects and 4-Coumarate-CoA Ligase (4CL); This family ...

3113-3182

4.94e-08

Pssm-ID: 341237 [Multi-domain] Cd Length: 486 Bit Score: 58.38 E-value: 4.94e-08

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3113 YAELNRRANRLAHALIERGIGADRLVGVAMERSIEMVVALMAILKAGGAYVPVDPEYPEERQAYMLEDSG 3182
Cdd:cd05911     13 YAQLRTLSRRLAAGLRKLGLKKGDVVGIISPNSTYYPPVFLGCLFAGGIFSAANPIYTADELAHQLKISK 82

LC_FACS_bac1

cd17641

bacterial long-chain fatty acid CoA synthetase; The members of this family are bacterial ...

1596-2016

5.23e-08

Pssm-ID: 341296 [Multi-domain] Cd Length: 569 Bit Score: 58.59 E-value: 5.23e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1596 YGELNLRANRLAHRLIELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGYMIEDSGIRLLLT--QR 1673
Cdd:cd17641     14 WADYADRVRAFALGLLALGVGRGDVVAILGDNRPEWVWAELAAQAIGALSLGIYQDSMAEEVAYLLNYTGARVVIAedEE 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1674 AARERLPLGEGLPCL------------------LLDAEHEWA---GYPESDPQ------SAVGVDNLAYVIYTSGSTGKP 1726
Cdd:cd17641     94 QVDKLLEIADRIPSVryviycdprgmrkyddprLISFEDVVAlgrALDRRDPGlyerevAAGKGEDVAVLCTTSGTTGKP 173

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1727 KGTLLPHGNVLRLfDATRHWFGFSADDAWSLfhSY-------AFDFSVweifGALLHGGRLVIVPYETSRSPEDfLR--- 1796
Cdd:cd17641    174 KLAMLSHGNFLGH-CAAYLAADPLGPGDEYV--SVlplpwigEQMYSV----GQALVCGFIVNFPEEPETMMED-LReig 245

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1797 -------------LLCRERVTVLNQTP---SAFKQLMQVACAG------QEVPPLALRHVVFGGEALEVQALRpwfERFG 1854
Cdd:cd17641    246 ptfvllpprvwegIAADVRARMMDATPfkrFMFELGMKLGLRAldrgkrGRPVSLWLRLASWLADALLFRPLR---DRLG 322

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1855 DRAPR-----------------------LVNMYGITETTVHVTYRPLSLADLDggaasPIGEPIPDLSWYLLDAGlnpvp 1911
Cdd:cd17641    323 FSRLRsaatggaalgpdtfrffhaigvpLKQLYGQTELAGAYTVHRDGDVDPD-----TVGVPFPGTEVRIDEVG----- 392

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1912 rgcigELYVGGAGLARGYLNRPELSCTRFVADPFsttggrlYRTGDLARYRCDGVVEYVGRI-DHQVKIRGFRIELGEIE 1990
Cdd:cd17641    393 -----EILVRSPGVFVGYYKNPEATAEDFDEDGW-------LHTGDAGYFKENGHLVVIDRAkDVGTTSDGTRFSPQFIE 460

                          490       500
                   ....*....|....*....|....*.
gi 2183974163 1991 ARLLAQPGVAEAVVLPHEGPGATQLV 2016
Cdd:cd17641    461 NKLKFSPYIAEAVVLGAGRPYLTAFI 486

PRK12476

putative fatty-acid--CoA ligase; Provisional

563-1006

6.10e-08

putative fatty-acid--CoA ligase; Provisional

Pssm-ID: 171527 [Multi-domain] Cd Length: 612 Bit Score: 58.60 E-value: 6.10e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  563 VGIALERGVPMVVALLAVLKAGGAYVPL-DPQYP--ADRLQYMIDDSGLRLLLSQQSV-------LARLPQSDGLQSLLL 632
Cdd:PRK12476    95 VAILAPQGIDYVAGFFAAIKAGTIAVPLfAPELPghAERLDTALRDAEPTVVLTTTAAaeavegfLRNLPRLRRPRVIAI 174

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  633 DDL-ERLVHGYPAENPDLpeapDSLCYAIYTSGSTGQPKGVMVRHRAL-TNFVCSIarqpgmlardrlLSVTTFSFDIFG 710
Cdd:PRK12476   175 DAIpDSAGESFVPVELDT----DDVSHLQYTSGSTRPPVGVEITHRAVgTNLVQMI------------LSIDLLDRNTHG 238

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  711 ---LELY---------VPLARGASMLLAS-----REQAQDPEALLDlvERQGVTVLQATP------ATWRML-CDSERVD 766
Cdd:PRK12476   239 vswLPLYhdmglsmigFPAVYGGHSTLMSptafvRRPQRWIKALSE--GSRTGRVVTAAPnfayewAAQRGLpAEGDDID 316

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  767 lLRGCTLLCGGEALAEDlAARMRGLSASTWNL--------YGPTETTIWSA--------------RFRLG---------- 814
Cdd:PRK12476   317 -LSNVVLIIGSEPVSID-AVTTFNKAFAPYGLprtafkpsYGIAEATLFVAtiapdaepsvvyldREQLGagravrvaad 394

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  815 -EEARPFL--GGPLENTALYILDSEM-NPCPPGVAGELLIGGDGLARGYHRRPGLTAERF-------LPDPFAADGS--- 880
Cdd:PRK12476   395 aPNAVAHVscGQVARSQWAVIVDPDTgAELPDGEVGEIWLHGDNIGRGYWGRPEETERTFgaklqsrLAEGSHADGAadd 474

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  881 -RLYRTGDLARYRaDGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQD-SVREAVVVA--QPGVAGPTLVayLVPTEAA- 955
Cdd:PRK12476   475 gTWLRTGDLGVYL-DGELYITGRIADLIVIDGRNHYPQDIEATVAEASpMVRRGYVTAftVPAEDNERLV--IVAERAAg 551

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2183974163  956 --LVDAESArQQELRSALKNS-LLAVLPDYMVPAHMlllenLPLTPNGKINRKA 1006
Cdd:PRK12476   552 tsRADPAPA-IDAIRAAVSRRhGLAVADVRLVPAGA-----IPRTTSGKLARRA 599

CHC_CoA_lg

cd05903

Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); ...

3110-3181

8.59e-08

Pssm-ID: 341229 [Multi-domain] Cd Length: 437 Bit Score: 57.78 E-value: 8.59e-08

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2183974163 3110 RLDYAELNRRANRLAHALIERGIGADRLVGVAMERSIEMVVALMAILKAGGAYVPVDPEYPEERQAYMLEDS 3181
Cdd:cd05903      1 RLTYSELDTRADRLAAGLAALGVGPGDVVAFQLPNWWEFAVLYLACLRIGAVTNPILPFFREHELAFILRRA 72

AACS_like

cd05968

Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; This ...

3087-3182

1.57e-07

Pssm-ID: 341272 [Multi-domain] Cd Length: 610 Bit Score: 57.11 E-value: 1.57e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3087 VHRLFEEQVERTPTAPALAFGEER-----LDYAELNRRANRLAHALIERGIGADRLVGVAMERSIEMVVALMAILKAGGA 3161
Cdd:cd05968     63 VEQLLDKWLADTRTRPALRWEGEDgtsrtLTYGELLYEVKRLANGLRALGVGKGDRVGIYLPMIPEIVPAFLAVARIGGI 142

                           90       100
                   ....*....|....*....|.
gi 2183974163 3162 YVPVDPEYPEERQAYMLEDSG 3182
Cdd:cd05968    143 VVPIFSGFGKEAAATRLQDAE 163

PLN02654

acetate-CoA ligase

533-1023

1.59e-07

acetate-CoA ligase

Pssm-ID: 215353 [Multi-domain] Cd Length: 666 Bit Score: 57.21 E-value: 1.59e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  533 EERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQYMIDDSGLRLLL 612
Cdd:PLN02654   118 DASLTYSELLDRVCQLANYLKDVGVKKGDAVVIYLPMLMELPIAMLACARIGAVHSVVFAGFSAESLAQRIVDCKPKVVI 197

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  613 SQQSVlARLPQSDGLQSLLLDDLERLV-HGYPA------EN-----------------------PDLP--------EAPD 654
Cdd:PLN02654   198 TCNAV-KRGPKTINLKDIVDAALDESAkNGVSVgicltyENqlamkredtkwqegrdvwwqdvvPNYPtkcevewvDAED 276

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  655 SLcYAIYTSGSTGQPKGV-------MVRhrALTNFVCSIARQPGML--ARDRLLSVTTFSFDIFGlelyvPLARGASMLL 725
Cdd:PLN02654   277 PL-FLLYTSGSTGKPKGVlhttggyMVY--TATTFKYAFDYKPTDVywCTADCGWITGHSYVTYG-----PMLNGATVLV 348

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  726 -ASREQAQDPEALLDLVERQGVTVLQATPATWRMLCDServdllrgctllcGGEALAEDLAARMRGL---------SAST 795
Cdd:PLN02654   349 fEGAPNYPDSGRCWDIVDKYKVTIFYTAPTLVRSLMRD-------------GDEYVTRHSRKSLRVLgsvgepinpSAWR 415

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  796 W--NLYG----PTETTIWSAR---FRL-----------GEEARPFLG-GPLentalyILDSEMNPCPPGVAGELLIGGD- 853
Cdd:PLN02654   416 WffNVVGdsrcPISDTWWQTEtggFMItplpgawpqkpGSATFPFFGvQPV------IVDEKGKEIEGECSGYLCVKKSw 489

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  854 -GLAR---GYHRRPGLTAERflpdPFAAdgsrLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSV 929
Cdd:PLN02654   490 pGAFRtlyGDHERYETTYFK----PFAG----YYFSGDGCSRDKDGYYWLTGRVDDVINVSGHRIGTAEVESALVSHPQC 561

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  930 REAVVVA-QPGVAGPTLVAYLvpteaALVDAESaRQQELRSALKNSLLAVLPDYMVPAHMLLLENLPLTPNGKINRKAL- 1007
Cdd:PLN02654   562 AEAAVVGiEHEVKGQGIYAFV-----TLVEGVP-YSEELRKSLILTVRNQIGAFAAPDKIHWAPGLPKTRSGKIMRRILr 635

                          570       580
                   ....*....|....*....|....
gi 2183974163 1008 --------PLPDASAVRDAHVAPE 1023
Cdd:PLN02654   636 kiasrqldELGDTSTLADPGVVDQ 659

PRK07445

O-succinylbenzoic acid--CoA ligase; Reviewed

842-1008

2.07e-07

O-succinylbenzoic acid--CoA ligase; Reviewed

Pssm-ID: 236019 [Multi-domain] Cd Length: 452 Bit Score: 56.54 E-value: 2.07e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  842 PGVAGELLIGGDGLARGYHrrpgltaerflpdPFAADGSRLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIET 921
Cdd:PRK07445   298 ANQTGNITIQAQSLALGYY-------------PQILDSQGIFETDDLGYLDAQGYLHILGRNSQKIITGGENVYPAEVEA 364

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  922 RLLEQDSVREAVVVAQP-GVAGPTLVAYLVPteaalvDAESARQQELRSALKNSLLAvlpdYMVPAHMLLLENLPLTPNG 1000
Cdd:PRK07445   365 AILATGLVQDVCVLGLPdPHWGEVVTAIYVP------KDPSISLEELKTAIKDQLSP----FKQPKHWIPVPQLPRNPQG 434


                   ....*...
gi 2183974163 1001 KINRKALP 1008
Cdd:PRK07445   435 KINRQQLQ 442

PRK07470

acyl-CoA synthetase; Validated

3097-3183

2.13e-07

acyl-CoA synthetase; Validated

Pssm-ID: 180988 [Multi-domain] Cd Length: 528 Bit Score: 56.59 E-value: 2.13e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3097 RTPTAPALAFGEERLDYAELNRRANRLAHALIERGIG-ADRLVgVAMERSIEMVVALMAILKAGGAYVPVDPEYPEERQA 3175
Cdd:PRK07470    19 RFPDRIALVWGDRSWTWREIDARVDALAAALAARGVRkGDRIL-VHSRNCNQMFESMFAAFRLGAVWVPTNFRQTPDEVA 97


                   ....*...
gi 2183974163 3176 YMLEDSGV 3183
Cdd:PRK07470    98 YLAEASGA 105

LC_FACS_like

cd05935

Putative long-chain fatty acid CoA ligase; The members of this family are putative long-chain ...

3110-3182

2.76e-07

Pssm-ID: 341258 [Multi-domain] Cd Length: 430 Bit Score: 55.95 E-value: 2.76e-07

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2183974163 3110 RLDYAELNRRANRLAHALIERGIGADRLVGVAMERSIEMVVALMAILKAGGAYVPVDPEYPEERQAYMLEDSG 3182
Cdd:cd05935      1 SLTYLELLEVVKKLASFLSNKGVRKGDRVGICLQNSPQYVIAYFAIWRANAVVVPINPMLKERELEYILNDSG 73

PRK08315

AMP-binding domain protein; Validated

3089-3183

2.85e-07

AMP-binding domain protein; Validated

Pssm-ID: 236236 [Multi-domain] Cd Length: 559 Bit Score: 56.36 E-value: 2.85e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3089 RLFEEQVERTPTAPALAFGEE--RLDYAELNRRANRLAHALIERGIGA-DRlVGV-AMERsIEMVVALMAILKAGGAYVP 3164
Cdd:PRK08315    20 QLLDRTAARYPDREALVYRDQglRWTYREFNEEVDALAKGLLALGIEKgDR-VGIwAPNV-PEWVLTQFATAKIGAILVT 97

                           90
                   ....*....|....*....
gi 2183974163 3165 VDPEYPEERQAYMLEDSGV 3183
Cdd:PRK08315    98 INPAYRLSELEYALNQSGC 116

FACL_DitJ_like

cd05934

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ...

3108-3182

2.85e-07

Pssm-ID: 341257 [Multi-domain] Cd Length: 422 Bit Score: 55.76 E-value: 2.85e-07

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2183974163 3108 EERLDYAELNRRANRLAHALIERGIGADRLVGVAMERSIEMVVALMAILKAGGAYVPVDPEYPEERQAYMLEDSG 3182
Cdd:cd05934      1 GRRWTYAELLRESARIAAALAALGIRPGDRVALMLDNCPEFLFAWFALAKLGAVLVPINTALRGDELAYIIDHSG 75

23DHB-AMP_lg

cd05920

2,3-dihydroxybenzoate-AMP ligase; 2,3-dihydroxybenzoate-AMP ligase activates 2, ...

3063-3165

6.28e-07

Pssm-ID: 341244 [Multi-domain] Cd Length: 482 Bit Score: 55.03 E-value: 6.28e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3063 AVAERYqllegwnaTAAEYPLQRGVHRLFEEQVERTPTAPALAFGEERLDYAELNRRANRLAHALIERGIG-ADRLVgVA 3141
Cdd:cd05920      1 EFARRY--------RAAGYWQDEPLGDLLARSAARHPDRIAVVDGDRRLTYRELDRRADRLAAGLRGLGIRpGDRVV-VQ 71

                           90       100
                   ....*....|....*....|....
gi 2183974163 3142 MERSIEMVVALMAILKAGGayVPV 3165
Cdd:cd05920     72 LPNVAEFVVLFFALLRLGA--VPV 93

PRK06145

acyl-CoA synthetase; Validated

3097-3182

7.97e-07

acyl-CoA synthetase; Validated

Pssm-ID: 102207 [Multi-domain] Cd Length: 497 Bit Score: 54.51 E-value: 7.97e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3097 RTPTAPALAFGEERLDYAELNRRANRLAHALIERGIGADRLVGVAMERSIEMVVALMAILKAGGAYVPVDPEYPEERQAY 3176
Cdd:PRK06145    14 RTPDRAALVYRDQEISYAEFHQRILQAAGMLHARGIGQGDVVALLMKNSAAFLELAFAASYLGAVFLPINYRLAADEVAY 93


                   ....*.
gi 2183974163 3177 MLEDSG 3182
Cdd:PRK06145    94 ILGDAG 99

FATP_FACS

cd05940

Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its ...

3108-3161

9.12e-07

Pssm-ID: 341263 [Multi-domain] Cd Length: 449 Bit Score: 54.28 E-value: 9.12e-07

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2183974163 3108 EERLDYAELNRRANRLAHALIERGIGADRLVGVAMERSIEMVVALMAILKAGGA 3161
Cdd:cd05940      1 DEALTYAELDAMANRYARWLKSLGLKPGDVVALFMENRPEYVLLWLGLVKIGAV 54

PRK12583

acyl-CoA synthetase; Provisional

3090-3183

1.01e-06

acyl-CoA synthetase; Provisional

Pssm-ID: 237145 [Multi-domain] Cd Length: 558 Bit Score: 54.39 E-value: 1.01e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3090 LFEEQVERTPTAPALAFGEE--RLDYAELNRRANRLAHALIERGIGADRLVGVAMERSIEMVVALMAILKAGGAYVPVDP 3167
Cdd:PRK12583    23 AFDATVARFPDREALVVRHQalRYTWRQLADAVDRLARGLLALGVQPGDRVGIWAPNCAEWLLTQFATARIGAILVNINP 102

                           90
                   ....*....|....*.
gi 2183974163 3168 EYPEERQAYMLEDSGV 3183
Cdd:PRK12583   103 AYRASELEYALGQSGV 118

hsFATP4_like

cd05939

Fatty acid transport proteins (FATP), including FATP4 and FATP1, and similar proteins; Fatty ...

534-1007

1.46e-06

Pssm-ID: 341262 [Multi-domain] Cd Length: 474 Bit Score: 53.97 E-value: 1.46e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  534 ERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGAYVPLDPQYPADRLQYMIDDSGLRLLLS 613
Cdd:cd05939      2 RHWTFRELNEYSNKVANFFQAQGYRSGDVVALFMENRLEFVALWLGLAKIGVETALINSNLRLESLLHCITVSKAKALIF 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  614 QqsvlarlpqsdglqslLLDDLERLVHGYPAENPDLpEAPDSLCYaIYTSGSTGQPKGVMVRHraltnfvcsiarqpgml 693
Cdd:cd05939     82 N----------------LLDPLLTQSSTEPPSQDDV-NFRDKLFY-IYTSGTTGLPKAAVIVH----------------- 126

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  694 arDRLLSVTTFSFDIFGLE----LYVPL----------ARGASMLLAS----REQAQDPEALLDLVeRQGVTVLQATPAT 755
Cdd:cd05939    127 --SRYYRIAAGAYYAFGMRpedvVYDCLplyhsaggimGVGQALLHGStvviRKKFSASNFWDDCV-KYNCTIVQYIGEI 203

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  756 WRML-----CDSERVDLLRgctLLCGGealaedlaarmrGLSASTWN-------------LYGPTETTIWSARF--RLGe 815
Cdd:cd05939    204 CRYLlaqppSEEEQKHNVR---LAVGN------------GLRPQIWEqfvrrfgipqigeFYGATEGNSSLVNIdnHVG- 267

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  816 eARPFLGGPL------------ENTALYILDSE--MNPCPPGVAGEL---LIGGDGLAR--GYHRRpGLTAERFLPDPFA 876
Cdd:cd05939    268 -ACGFNSRILpsvypirlikvdEDTGELIRDSDglCIPCQPGEPGLLvgkIIQNDPLRRfdGYVNE-GATNKKIARDVFK 345

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  877 AdGSRLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVV--VAQPGVAGPTLVaylvpteA 954
Cdd:cd05939    346 K-GDSAFLSGDVLVMDELGYLYFKDRTGDTFRWKGENVSTTEVEGILSNVLGLEDVVVygVEVPGVEGRAGM-------A 417

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2183974163  955 ALVDAESARQQELRSAlknSLLAVLPDYMVPAHMLLLENLPLTPNGKINRKAL 1007
Cdd:cd05939    418 AIVDPERKVDLDRFSA---VLAKSLPPYARPQFIRLLPEVDKTGTFKLQKTDL 467

PRK05851

long-chain-fatty acid--ACP ligase MbtM;

535-1004

1.72e-06

long-chain-fatty acid--ACP ligase MbtM;

Pssm-ID: 180289 [Multi-domain] Cd Length: 525 Bit Score: 53.62 E-value: 1.72e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  535 RLSYAELNALA-NRLAWRLREEGVGSDVLVGialERGVPMVVALLAVLKAGGAYVPL-------DPQYPADRLQYMIDDS 606
Cdd:PRK05851    31 RHPWPEVHGRAeNVAARLLDRDRPGAVGLVG---EPTVELVAAIQGAWLAGAAVSILpgpvrgaDDGRWADATLTRFAGI 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  607 GLRLLLSQQSVLARLPQSDGlqSLLLDDLERLVHgypAENPDLPEAPDSLCYAIY--TSGSTGQPKGVMVRHRALTNFVC 684
Cdd:PRK05851   108 GVRTVLSHGSHLERLRAVDS--SVTVHDLATAAH---TNRSASLTPPDSGGPAVLqgTAGSTGTPRTAILSPGAVLSNLR 182

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  685 SIARQPGM-LARDRLLSVTTFSFDIfGLELYVPLA-RGASMLLA-SREQAQDPEALLDLVERQGVTVLQATPATWRMLCD 761
Cdd:PRK05851   183 GLNARVGLdAATDVGCSWLPLYHDM-GLAFLLTAAlAGAPLWLApTTAFSASPFRWLSWLSDSRATLTAAPNFAYNLIGK 261

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  762 SER----VDLLRGCTLLCGGEALAEDLAARMR------GLSA-STWNLYGPTETTIWSARFRLGEEAR------------ 818
Cdd:PRK05851   262 YARrvsdVDLGALRVALNGGEPVDCDGFERFAtamapfGFDAgAAAPSYGLAESTCAVTVPVPGIGLRvdevttddgsga 341

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  819 ---PFLGGPLENTALYILDSEMnpcPPGVA----GELLIGGDGLARGYhrrpgltaerFLPDPFAADGsrLYRTGDLArY 891
Cdd:PRK05851   342 rrhAVLGNPIPGMEVRISPGDG---AAGVAgreiGEIEIRGASMMSGY----------LGQAPIDPDD--WFPTGDLG-Y 405

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  892 RADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVREAVVVA---QPGVAGPTLVaylVPTEAALVDAESArqqelR 968
Cdd:PRK05851   406 LVDGGLVVCGRAKELITVAGRNIFPTEIERVAAQVRGVREGAVVAvgtGEGSARPGLV---IAAEFRGPDEAGA-----R 477

                          490       500       510
                   ....*....|....*....|....*....|....*...
gi 2183974163  969 SALKNSLLAVLPdyMVPAHMLLLE--NLPLTPNGKINR 1004
Cdd:PRK05851   478 SEVVQRVASECG--VVPSDVVFVApgSLPRTSSGKLRR 513

PRK05852

fatty acid--CoA ligase family protein;

3090-3183

2.01e-06

fatty acid--CoA ligase family protein;

Pssm-ID: 235625 [Multi-domain] Cd Length: 534 Bit Score: 53.35 E-value: 2.01e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3090 LFEEQVERTPTAPALAFGEER--LDYAELNRRANRLAHALIERGIGADRLVGVAMERSIEMVVALMAILKAGGAYVPVDP 3167
Cdd:PRK05852    21 LVEVAATRLPEAPALVVTADRiaISYRDLARLVDDLAGQLTRSGLLPGDRVALRMGSNAEFVVALLAASRADLVVVPLDP 100

                           90
                   ....*....|....*.
gi 2183974163 3168 EYPEERQAYMLEDSGV 3183
Cdd:PRK05852   101 ALPIAEQRVRSQAAGA 116

hsFATP2a_ACSVL_like

cd05938

Fatty acid transport proteins (FATP) including hsFATP2, hsFATP5, and hsFATP6, and similar ...

531-760

2.03e-06

Fatty acid transport proteins (FATP) including hsFATP2, hsFATP5, and hsFATP6, and similar proteins; Fatty acid transport proteins (FATP) of this family transport long-chain or very-long-chain fatty acids across the plasma membrane. At least five copies of FATPs are identified in mammalian cells. This family includes hsFATP2, hsFATP5, and hsFATP6, and similar proteins. Each FATP has unique patterns of tissue distribution. These FATPs also have fatty acid CoA synthetase activity, thus playing dual roles as fatty acid transporters and its activation enzymes. The hsFATP proteins exist in two splice variants; the b variant, lacking exon 3, has no acyl-CoA synthetase activity. FATPs are key players in the trafficking of exogenous fatty acids into the cell and in intracellular fatty acid homeostasis.

Pssm-ID: 341261 [Multi-domain] Cd Length: 537 Bit Score: 53.45 E-value: 2.03e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  531 FGEERLSYAELNALANRLAWRLREE-GVGSDVLVGIALERGvPMVVAL-LAVLKAGGAYVPLDPQYPADRLQYMIDDSGL 608
Cdd:cd05938      1 FEGETYTYRDVDRRSNQAARALLAHaGLRPGDTVALLLGNE-PAFLWIwLGLAKLGCPVAFLNTNIRSKSLLHCFRCCGA 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  609 RLLLS----QQSVLARLP--QSDGLQSLLL---------DDLERLVHGYPAENP--DL--PEAPDSLCYAIYTSGSTGQP 669
Cdd:cd05938     80 KVLVVapelQEAVEEVLPalRADGVSVWYLshtsntegvISLLDKVDAASDEPVpaSLraHVTIKSPALYIYTSGTTGLP 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  670 KGVMVRHRALTnFVCSIARQPGMLARDRL-LSVTTFSFDIFGLELYVPLARGASMLLASREQAQDpeaLLDLVERQGVTV 748
Cdd:cd05938    160 KAARISHLRVL-QCSGFLSLCGVTADDVIyITLPLYHSSGFLLGIGGCIELGATCVLKPKFSASQ---FWDDCRKHNVTV 235

                          250
                   ....*....|..
gi 2183974163  749 LQATPATWRMLC 760
Cdd:cd05938    236 IQYIGELLRYLC 247

PRK08180

feruloyl-CoA synthase; Reviewed

3082-3169

2.03e-06

feruloyl-CoA synthase; Reviewed

Pssm-ID: 236175 [Multi-domain] Cd Length: 614 Bit Score: 53.73 E-value: 2.03e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3082 PLQRGVHRLFEEQVERTPTAPALA-----FGEERLDYAELNRRANRLAHALIERGIGADRLVGVAMERSIEMVVALMAIL 3156
Cdd:PRK08180    36 DYPRRLTDRLVHWAQEAPDRVFLAergadGGWRRLTYAEALERVRAIAQALLDRGLSAERPLMILSGNSIEHALLALAAM 115

                           90
                   ....*....|...
gi 2183974163 3157 KAGGAYVPVDPEY 3169
Cdd:PRK08180   116 YAGVPYAPVSPAY 128

PksD

COG3321

Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites ...

254-793

2.04e-06

Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism];

Pssm-ID: 442550 [Multi-domain] Cd Length: 1386 Bit Score: 54.11 E-value: 2.04e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  254 PTDRQRPALPSYRGARHELQLPQALGRQLQALAQREGTTLFMLLLASFQALLHRYSGQDEIRVGVPVANRNRVETERLIG 333
Cdd:COG3321    855 GRGRRRVPLPTYPFQREDAAAALLAAALAAALAAAAALGALLLAALAAALAAALLALAAAAAAALALAAAALAALLALVA 934

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  334 FFVNTQVLRADLDAQMPFLDLLQQTRVAALGAQSHQDLPFEQLVEALQPERSLShsplfqamynhqnLGSAGRQSLAAQL 413
Cdd:COG3321    935 LAAAAAALLALAAAAAAAAAALAAAEAGALLLLAAAAAAAAAAAAAAAAAAAAA-------------AAAAAAALAAAAA 1001

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  414 PGLSVEDLSWGAHSAQFDLTLDTYESEQGVHAEFTYATDLFEAATVERLARHWRNLLEAVVAEPRRRLGDLPLLDAEERA 493
Cdd:COG3321   1002 LALLAAAALLLAAAAAAAALLALAALLAAAAAALAAAAAAAAAAAALAALAAAAAAAAALALALAALLLLAALAELALAA 1081

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  494 TLLQRSRLPASEYPAGQGVHRLFEAQAGLTPDAPALLFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPM 573
Cdd:COG3321   1082 AALALAAALAAAALALALAALAAALLLLALLAALALAAAAAALLALAALLAAAAAAAALAAAAAAAAALALAAAAAALAA 1161

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  574 VVALLAVLKAGGAYVPLDPQYPADRLQYMIDDSGLRL--LLSQQSVLARLPQSDGLQSLLLDDLERLVHGYPAENPDLPE 651
Cdd:COG3321   1162 ALAAALLAAAALLLALALALAAALAAALAGLAALLLAalLAALLAALLALALAALAAAAAALLAAAAAAAALALLALAAA 1241

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  652 APDSLCYAIYTSGSTGQPKGVMVRHRALTnfvcsiARQPGMLARDRLLSVTTFSFDIFGLELYVPLARGASMLLASREQA 731
Cdd:COG3321   1242 AAAVAALAAAAAALLAALAALALLAAAAG------LAALAAAAAAAAAALALAAAAAAAAAALAALLAAAAAAAAAAAAA 1315

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2183974163  732 QDPEALLDLVERQGVTVLQATPATWRMLCDSERVDLLRGCTLLCGGEALAEDLAARMRGLSA 793
Cdd:COG3321   1316 AAAAALAAALLAAALAALAAAVAAALALAAAAAAAAAAAAAAAAAAALAAAAGAAAAAAALA 1377

PRK06814

acyl-[ACP]--phospholipid O-acyltransferase;

631-1003

2.15e-06

acyl-[ACP]--phospholipid O-acyltransferase;

Pssm-ID: 235865 [Multi-domain] Cd Length: 1140 Bit Score: 53.82 E-value: 2.15e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  631 LLDDLERLVHGYPAENPDLPEAPDSLCYAIYTSGSTGQPKGVMVRHRA-LTNFVCSIARQPgMLARDRLLSVTTFsFDIF 709
Cdd:PRK06814   770 LADKIKGLLAGRFPLVYFCNRDPDDPAVILFTSGSEGTPKGVVLSHRNlLANRAQVAARID-FSPEDKVFNALPV-FHSF 847

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  710 GLE--LYVPLARGASMLLAsreqaqdPEAL-----LDLVERQGVTVLQATPAtwrMLCDSERV----DL--LRGCTllcg 776
Cdd:PRK06814   848 GLTggLVLPLLSGVKVFLY-------PSPLhyriiPELIYDTNATILFGTDT---FLNGYARYahpyDFrsLRYVF---- 913

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  777 geALAEDLAARMRGLSASTWNL-----YGPTETTIWSA-----RFRLGEEARpflggplentALYILDSEMNPCPpGV-- 844
Cdd:PRK06814   914 --AGAEKVKEETRQTWMEKFGIrilegYGVTETAPVIAlntpmHNKAGTVGR----------LLPGIEYRLEPVP-GIde 980

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  845 AGELLIGGDGLARGYHR--RPGLTAErflpdpfAADGsrLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETR 922
Cdd:PRK06814   981 GGRLFVRGPNVMLGYLRaeNPGVLEP-------PADG--WYDTGDIVTIDEEGFITIKGRAKRFAKIAGEMISLAAVEEL 1051

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  923 LLEQDSVREAVVVAQP-GVAGPTLVayLVPTEAalvDAEsaRQQELRSALKNSllavLPDYMVPAHMLLLENLPLTPNGK 1001
Cdd:PRK06814  1052 AAELWPDALHAAVSIPdARKGERII--LLTTAS---DAT--RAAFLAHAKAAG----ASELMVPAEIITIDEIPLLGTGK 1120


                   ..
gi 2183974163 1002 IN 1003
Cdd:PRK06814  1121 ID 1122

VL_LC_FACS_like

cd05907

Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA ...

3111-3183

2.36e-06

Pssm-ID: 341233 [Multi-domain] Cd Length: 452 Bit Score: 52.98 E-value: 2.36e-06

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2183974163 3111 LDYAELNRRANRLAHALIERGIGADRLVGVAMERSIEMVVALMAILKAGGAYVPVDPEYPEERQAYMLEDSGV 3183
Cdd:cd05907      6 ITWAEFAEEVRALAKGLIALGVEPGDRVAILSRNRPEWTIADLAILAIGAVPVPIYPTSSAEQIAYILNDSEA 78

PRK06710

long-chain-fatty-acid--CoA ligase; Validated

3087-3182

3.22e-06

long-chain-fatty-acid--CoA ligase; Validated

Pssm-ID: 180666 [Multi-domain] Cd Length: 563 Bit Score: 52.73 E-value: 3.22e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3087 VHRLFEEQVERTPTAPALAFGEERLDYAELNRRANRLAHALIERGIGADRLVGVAMERSIEMVVALMAILKAGGAYVPVD 3166
Cdd:PRK06710    26 LHKYVEQMASRYPEKKALHFLGKDITFSVFHDKVKRFANYLQKLGVEKGDRVAIMLPNCPQAVIGYYGTLLAGGIVVQTN 105

                           90
                   ....*....|....*.
gi 2183974163 3167 PEYPEERQAYMLEDSG 3182
Cdd:PRK06710   106 PLYTERELEYQLHDSG 121

PRK13295

cyclohexanecarboxylate-CoA ligase; Reviewed

3058-3179

4.48e-06

cyclohexanecarboxylate-CoA ligase; Reviewed

Pssm-ID: 171961 [Multi-domain] Cd Length: 547 Bit Score: 52.36 E-value: 4.48e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3058 ELDSLAVAERYQLlegwnATAAEYPLQRGVHRLFEEQVERTPTAPALA------FGEERLDYAELNRRANRLAHALIERG 3131
Cdd:PRK13295     2 EFDAVLLPPRRAA-----SIAAGHWHDRTINDDLDACVASCPDKTAVTavrlgtGAPRRFTYRELAALVDRVAVGLARLG 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 2183974163 3132 IGADRLVGVAMERSIEMVVALMAILKAGGAYVPVDPEYPEERQAYMLE 3179
Cdd:PRK13295    77 VGRGDVVSCQLPNWWEFTVLYLACSRIGAVLNPLMPIFRERELSFMLK 124

MACS_like_3

cd05971

Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the ...

3109-3182

5.99e-06

Pssm-ID: 341275 [Multi-domain] Cd Length: 439 Bit Score: 51.66 E-value: 5.99e-06

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2183974163 3109 ERLDYAELNRRANRLAHALIERGIGADRLVGVAMERSIEMVVALMAILKAGGAYVPVDPEYPEERQAYMLEDSG 3182
Cdd:cd05971      5 EKVTFKELKTASNRFANVLKEIGLEKGDRVGVFLSQGPECAIAHIAILRSGAIAVPLFALFGPEALEYRLSNSG 78

PRK13391

acyl-CoA synthetase; Provisional

3095-3182

6.03e-06

acyl-CoA synthetase; Provisional

Pssm-ID: 184022 [Multi-domain] Cd Length: 511 Bit Score: 52.00 E-value: 6.03e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3095 VERTPTAPALAFGE--ERLDYAELNRRANRLAHALIERGIGADRLVGVAMERSIEMVVALMAILKAGGAYVPVDPEYPEE 3172
Cdd:PRK13391     7 AQTTPDKPAVIMAStgEVVTYRELDERSNRLAHLFRSLGLKRGDHVAIFMENNLRYLEVCWAAERSGLYYTCVNSHLTPA 86

                           90
                   ....*....|
gi 2183974163 3173 RQAYMLEDSG 3182
Cdd:PRK13391    87 EAAYIVDDSG 96

PaaK

COG1541

Phenylacetate-coenzyme A ligase PaaK, adenylate-forming domain family [Coenzyme transport and ...

662-979

6.30e-06

Phenylacetate-coenzyme A ligase PaaK, adenylate-forming domain family [Coenzyme transport and metabolism];

Pssm-ID: 441150 [Multi-domain] Cd Length: 423 Bit Score: 51.69 E-value: 6.30e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  662 TSGSTGQPKGVMVRHRALTNFVCSIAR---QPGMLARDRLLSvtTFSFDIF--------GLElyvplARGASMLLASreq 730
Cdd:COG1541     91 SSGTTGKPTVVGYTRKDLDRWAELFARslrAAGVRPGDRVQN--AFGYGLFtgglglhyGAE-----RLGATVIPAG--- 160

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  731 AQDPEALLDLVERQGVTVLQATPATWRMLCDSER---VDL----LRgcTLLCGGEALAEDLAARM-RGLSASTWNLYGPT 802
Cdd:COG1541    161 GGNTERQLRLMQDFGPTVLVGTPSYLLYLAEVAEeegIDPrdlsLK--KGIFGGEPWSEEMRKEIeERWGIKAYDIYGLT 238

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  803 ETTIWSArfrlGE-EARpflGGPLENTALY---ILDSEM-NPCPPGVAGELLIggdglargyhrrpglTaerflpdPFAA 877
Cdd:COG1541    239 EVGPGVA----YEcEAQ---DGLHIWEDHFlveIIDPETgEPVPEGEEGELVV---------------T-------TLTK 289

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  878 DGSRL--YRTGDLARY------------RADGVieyLGRIDHQVKIRGFRIELGEIetrlleqdsvrEAVVVAQPGVAGp 943
Cdd:COG1541    290 EAMPLirYRTGDLTRLlpepcpcgrthpRIGRI---LGRADDMLIIRGVNVFPSQI-----------EEVLLRIPEVGP- 354

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*
gi 2183974163  944 tlvAYL--VPTEAAL----VDAESAR---QQELRSALKNSLLAVL 979
Cdd:COG1541    355 ---EYQivVDREGGLdeltVRVELAPgasLEALAEAIAAALKAVL 396

PRK07787

acyl-CoA synthetase; Validated

3101-3183

6.46e-06

acyl-CoA synthetase; Validated

Pssm-ID: 236096 [Multi-domain] Cd Length: 471 Bit Score: 51.53 E-value: 6.46e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3101 APALAFGEERLDYAELNRRANRLAhaliERGIGADRlVGVAMERSIEMVVALMAILKAGGAYVPVDPEYPEERQAYMLED 3180
Cdd:PRK07787    16 ADAVRIGGRVLSRSDLAGAATAVA----ERVAGARR-VAVLATPTLATVLAVVGALIAGVPVVPVPPDSGVAERRHILAD 90


                   ...
gi 2183974163 3181 SGV 3183
Cdd:PRK07787    91 SGA 93

LC_FACL_like

cd05914

Uncharacterized subfamily of fatty acid CoA ligase (FACL); The members of this family are ...

3104-3181

6.50e-06

Pssm-ID: 341240 [Multi-domain] Cd Length: 463 Bit Score: 51.67 E-value: 6.50e-06

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2183974163 3104 LAFGEERLDYAELNRRANRLAHALIERGIGADRLVGVAMERSIEMVVALMAILKAGGAYVPVDPEYPEERQAYMLEDS 3181
Cdd:cd05914      1 LYYGGEPLTYKDLADNIAKFALLLKINGVGTGDRVALMGENRPEWGIAFFAIWTYGAIAVPILAEFTADEVHHILNHS 78

FAAL

cd05931

Fatty acyl-AMP ligase (FAAL); FAAL belongs to the class I adenylate forming enzyme family and ...

3095-3175

7.22e-06

Pssm-ID: 341254 [Multi-domain] Cd Length: 547 Bit Score: 51.86 E-value: 7.22e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3095 VERTPTAPALAF------GEERLDYAELNRRANRLAHALIERGIGADRlVGVAMERSIEMVVALMAILKAGGAYVPVDPe 3168
Cdd:cd05931      3 AAARPDRPAYTFlddeggREETLTYAELDRRARAIAARLQAVGKPGDR-VLLLAPPGLDFVAAFLGCLYAGAIAVPLPP- 80


                   ....*..
gi 2183974163 3169 yPEERQA 3175
Cdd:cd05931     81 -PTPGRH 86

PKS_PP

smart00823

Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the ...

2087-2153

9.28e-06

Pssm-ID: 214834 [Multi-domain] Cd Length: 86 Bit Score: 46.09 E-value: 9.28e-06

                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2183974163  2087 RSELEQRLAAIWADVLKLG---RVGLDDNFFELGGDSIISIQVVSRARQA-GIRLAPRDLFLHQTIRGLAG 2153
Cdd:smart00823   10 RRLLLDLVREQVAAVLGHAaaeAIDPDRPFRDLGLDSLMAVELRNRLEAAtGLRLPATLVFDHPTPAALAE 80

PRK08043

bifunctional acyl-ACP--phospholipid O-acyltransferase/long-chain-fatty-acid--ACP ligase;

649-1001

1.03e-05

bifunctional acyl-ACP--phospholipid O-acyltransferase/long-chain-fatty-acid--ACP ligase;

Pssm-ID: 181207 [Multi-domain] Cd Length: 718 Bit Score: 51.25 E-value: 1.03e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  649 LPEAPDSLCYAIYTSGSTGQPKGVMVRHRALTNFVCSIARQPGMLARDRLLSVTTFsFDIFGLE--LYVPLARGASMLLA 726
Cdd:PRK08043   360 VKQQPEDAALILFTSGSEGHPKGVVHSHKSLLANVEQIKTIADFTPNDRFMSALPL-FHSFGLTvgLFTPLLTGAEVFLY 438

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  727 sreqaqdPEALL-----DLVERQGVTVLQATpATWrmLCDSERV----DLLRGCTLLCGGEALAEdlaaRMRGLSASTWN 797
Cdd:PRK08043   439 -------PSPLHyrivpELVYDRNCTVLFGT-STF--LGNYARFanpyDFARLRYVVAGAEKLQE----STKQLWQDKFG 504

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  798 L-----YGPTETTIWSArFRLGEEARPFLGGPLentaLYILDSEMNPCpPGVA--GELLIGGDGLARGYHR--RPGLtae 868
Cdd:PRK08043   505 LrilegYGVTECAPVVS-INVPMAAKPGTVGRI----LPGMDARLLSV-PGIEqgGRLQLKGPNIMNGYLRveKPGV--- 575

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  869 rfLPDPFAADG-----SRLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIETRLLEQDSVRE-AVVVAQPGVAG 942
Cdd:PRK08043   576 --LEVPTAENArgemeRGWYDTGDIVRFDEQGFVQIQGRAKRFAKIAGEMVSLEMVEQLALGVSPDKQhATAIKSDASKG 653

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2183974163  943 PTLVayLVPTeaalvDAESARQQELRSALKNSllavLPDYMVPAHMLLLENLPLTPNGK 1001
Cdd:PRK08043   654 EALV--LFTT-----DSELTREKLQQYAREHG----VPELAVPRDIRYLKQLPLLGSGK 701

entE

PRK10946

(2,3-dihydroxybenzoyl)adenylate synthase;

3063-3165

1.03e-05

(2,3-dihydroxybenzoyl)adenylate synthase;

Pssm-ID: 236803 [Multi-domain] Cd Length: 536 Bit Score: 51.14 E-value: 1.03e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3063 AVAERYQLLEGWNataaEYPLQRgvhrLFEEQVErtPTAPALAFGEERLDYAELNRRANRLAHALIERGIGADRLVGVAM 3142
Cdd:PRK10946    11 EFARRYREKGYWQ----DLPLTD----ILTRHAA--SDAIAVICGERQFSYRELNQASDNLACSLRRQGIKPGDTALVQL 80

                           90       100
                   ....*....|....*....|...
gi 2183974163 3143 ERSIEMVVALMAILKAGgaYVPV 3165
Cdd:PRK10946    81 GNVAEFYITFFALLKLG--VAPV 101

PRK12406

long-chain-fatty-acid--CoA ligase; Provisional

3107-3182

1.56e-05

long-chain-fatty-acid--CoA ligase; Provisional

Pssm-ID: 183506 [Multi-domain] Cd Length: 509 Bit Score: 50.47 E-value: 1.56e-05

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2183974163 3107 GEERLDYAELNRRANRLAHALIERGIGADRLVGVAMERSIEMVVALMAILKAGGAYVPVDPEYPEERQAYMLEDSG 3182
Cdd:PRK12406     8 GDRRRSFDELAQRAARAAGGLAALGVRPGDCVALLMRNDFAFFEAAYAAMRLGAYAVPVNWHFKPEEIAYILEDSG 83

PRK06155

crotonobetaine/carnitine-CoA ligase; Provisional

3076-3182

1.60e-05

crotonobetaine/carnitine-CoA ligase; Provisional

Pssm-ID: 235719 [Multi-domain] Cd Length: 542 Bit Score: 50.53 E-value: 1.60e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3076 ATAAEYPLQRGVHRLFEEQVERTPTAPALAFGEERLDYAELNRRANRLAHALIERGIGADRLVGVAMERSIEMVVALMAI 3155
Cdd:PRK06155    12 AVDPLPPSERTLPAMLARQAERYPDRPLLVFGGTRWTYAEAARAAAAAAHALAAAGVKRGDRVALMCGNRIEFLDVFLGC 91

                           90       100
                   ....*....|....*....|....*..
gi 2183974163 3156 LKAGGAYVPVDPEYPEERQAYMLEDSG 3182
Cdd:PRK06155    92 AWLGAIAVPINTALRGPQLEHILRNSG 118

PLN02430

long-chain-fatty-acid-CoA ligase

645-953

1.96e-05

long-chain-fatty-acid-CoA ligase

Pssm-ID: 178049 [Multi-domain] Cd Length: 660 Bit Score: 50.58 E-value: 1.96e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  645 ENPD--LPEAPDSLCYAIYTSGSTGQPKGVMVRHRALTNFVCSI-----ARQPGMLARDRLLSvttfsfdifglelYVPL 717
Cdd:PLN02430   209 ENPSetNPPKPLDICTIMYTSGTSGDPKGVVLTHEAVATFVRGVdlfmeQFEDKMTHDDVYLS-------------FLPL 275

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  718 A-------------RGASM------LLASREQAQD--------------------PEALLDL--VERQGVTVLQATPATW 756
Cdd:PLN02430   276 AhildrmieeyffrKGASVgyyhgdLNALRDDLMElkptllagvprvferihegiQKALQELnpRRRLIFNALYKYKLAW 355

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  757 RMLCDSER-----VDLL-----------RGCTLLCGGEALAEDLAARMRGLS-ASTWNLYGPTETtiwsarfrLGEEARP 819
Cdd:PLN02430   356 MNRGYSHKkaspmADFLafrkvkaklggRLRLLISGGAPLSTEIEEFLRVTScAFVVQGYGLTET--------LGPTTLG 427

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  820 F---------LGGPLENTALYILD-SEM--NPCPPGVAGELLIGGDGLARGYHRRPGLTAERFlpdpfaADGsrLYRTGD 887
Cdd:PLN02430   428 FpdemcmlgtVGAPAVYNELRLEEvPEMgyDPLGEPPRGEICVRGKCLFSGYYKNPELTEEVM------KDG--WFHTGD 499

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2183974163  888 LARYRADGVIEYLGRIDHQVKI-RGFRIELGEIETRLLEQDSVREAVVVAQPgvAGPTLVAYLVPTE 953
Cdd:PLN02430   500 IGEILPNGVLKIIDRKKNLIKLsQGEYVALEYLENVYGQNPIVEDIWVYGDS--FKSMLVAVVVPNE 564

PksD

COG3321

Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites ...

47-586

2.08e-05

Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism];

Pssm-ID: 442550 [Multi-domain] Cd Length: 1386 Bit Score: 50.64 E-value: 2.08e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163   47 RIPL-SYAQERQWflwqmdpqSAAYNIPSALRLRGELDVEALSASLGAIVERHQSLRTVFVEDEQLDGFRQQVLASVDVP 125
Cdd:COG3321    860 RVPLpTYPFQRED--------AAAALLAAALAAALAAAAALGALLLAALAAALAAALLALAAAAAAALALAAAALAALLA 931

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  126 VPVTLAGDDDAQAQIRAFVESETQQPFDLRNGPLLRARLLRLAADDHVLTLTIHHVAADGWSMRVLVEELIALYGARRQG 205
Cdd:COG3321    932 LVALAAAAAALLALAAAAAAAAAALAAAEAGALLLLAAAAAAAAAAAAAAAAAAAAAAAAAAAALAAAAALALLAAAALL 1011

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  206 IEATLPdlpiqyadyaiwQRHWLEAGERERQLEYWMARLGGGQSVLELPTDRQRPALPSYRGARHELQLPQALGRQLQAL 285
Cdd:COG3321   1012 LAAAAA------------AAALLALAALLAAAAAALAAAAAAAAAAAALAALAAAAAAAAALALALAALLLLAALAELAL 1079

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  286 AQREGTTLFMLLLASFQALLHRYSGQDEIRVGVPVANRNRVETERLIGFFVNTQVLRADLDAQMPFLDLLQQTRVAALGA 365
Cdd:COG3321   1080 AAAALALAAALAAAALALALAALAAALLLLALLAALALAAAAAALLALAALLAAAAAAAALAAAAAAAAALALAAAAAAL 1159

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  366 QSHQDLPFEQLVEALQPERSLSHSPLFQAMYNHQNLGSAGRQSLAAQLPGLSVEDLSWGAHSAQFDLTLDTYESEQGVHA 445
Cdd:COG3321   1160 AAALAAALLAAAALLLALALALAAALAAALAGLAALLLAALLAALLAALLALALAALAAAAAALLAAAAAAAALALLALA 1239

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  446 EFTYATDLFEAATVERLARHWRNLLEAVVAEPRRRLGDLPLLDAEERATLLQRSRLPASEYPAGQGVHRLFEAQAGLTPD 525
Cdd:COG3321   1240 AAAAAVAALAAAAAALLAALAALALLAAAAGLAALAAAAAAAAAALALAAAAAAAAAALAALLAAAAAAAAAAAAAAAAA 1319

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2183974163  526 APALLFGEERLSYAELNALANRLAWRLREEGVGSDVLVGIALERGVPMVVALLAVLKAGGA 586
Cdd:COG3321   1320 ALAAALLAAALAALAAAVAAALALAAAAAAAAAAAAAAAAAAALAAAAGAAAAAAALALAA 1380

PRK07788

acyl-CoA synthetase; Validated

3096-3159

2.14e-05

acyl-CoA synthetase; Validated

Pssm-ID: 236097 [Multi-domain] Cd Length: 549 Bit Score: 50.31 E-value: 2.14e-05

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2183974163 3096 ERTPTAPALAFGEERLDYAELNRRANRLAHALIERGIGADRLVGVAMERSIEMVVALMAILKAG 3159
Cdd:PRK07788    60 RRAPDRAALIDERGTLTYAELDEQSNALARGLLALGVRAGDGVAVLARNHRGFVLALYAAGKVG 123

PRK06188

acyl-CoA synthetase; Validated

3095-3183

2.39e-05

acyl-CoA synthetase; Validated

Pssm-ID: 235731 [Multi-domain] Cd Length: 524 Bit Score: 49.98 E-value: 2.39e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3095 VERTPTAPALAFGEERLDYAELNRRANRLAHALIERGIGADRLVGVAMERSIEMVVALMAILKAGGAYVPVDPEYPEERQ 3174
Cdd:PRK06188    22 LKRYPDRPALVLGDTRLTYGQLADRISRYIQAFEALGLGTGDAVALLSLNRPEVLMAIGAAQLAGLRRTALHPLGSLDDH 101


                   ....*....
gi 2183974163 3175 AYMLEDSGV 3183
Cdd:PRK06188   102 AYVLEDAGI 110

PRK09274

peptide synthase; Provisional

3097-3167

2.41e-05

peptide synthase; Provisional

Pssm-ID: 236443 [Multi-domain] Cd Length: 552 Bit Score: 49.90 E-value: 2.41e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 3097 RTPTAPALAFGE----------ERLDYAELNRRANRLAHALIERGIGA-DRLvgVAMER-SIEMVVALMAILKAGGAYVP 3164
Cdd:PRK09274    18 ERPDQLAVAVPGgrgadgklayDELSFAELDARSDAIAHGLNAAGIGRgMRA--VLMVTpSLEFFALTFALFKAGAVPVL 95


                   ...
gi 2183974163 3165 VDP 3167
Cdd:PRK09274    96 VDP 98

PTZ00216

acyl-CoA synthetase; Provisional

532-903

2.45e-05

acyl-CoA synthetase; Provisional

Pssm-ID: 240316 [Multi-domain] Cd Length: 700 Bit Score: 49.97 E-value: 2.45e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  532 GEERLSYAelnalanrlawrLREEGVGSDVLVGialeRGVPMVVALLAVLKAGGAYVPLDPQYPADrlqymIDDSGLRLL 611
Cdd:PTZ00216   181 GEDALAYA------------LRETECKAIVCNG----KNVPNLLRLMKSGGMPNTTIIYLDSLPAS-----VDTEGCRLV 239

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  612 lSQQSVLArlpqsdglqsllLDDLERLVHGYPaenpdLPEAPDSLCYAIYTSGSTGQPKGVMVRHRALTNFVCSIArqpg 691
Cdd:PTZ00216   240 -AWTDVVA------------KGHSAGSHHPLN-----IPENNDDLALIMYTSGTTGDPKGVMHTHGSLTAGILALE---- 297

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  692 mlarDRLLsvttfsfDIFG----LELYV---PLA-------------RGASMLLASreqaqdPEALL--------DLVE- 742
Cdd:PTZ00216   298 ----DRLN-------DLIGppeeDETYCsylPLAhimefgvtniflaRGALIGFGS------PRTLTdtfarphgDLTEf 360

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  743 ---------------RQGVTVLQATPATW-RMLCDSERVDLLRGctLLCGGE---------ALAED-LAARMRG------ 790
Cdd:PTZ00216   361 rpvfligvprifdtiKKAVEAKLPPVGSLkRRVFDHAYQSRLRA--LKEGKDtpywnekvfSAPRAvLGGRVRAmlsggg 438

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  791 -LSASTWNL-----------YGPTETTIWSARFRLGEEArPFLGGPLENTA-LYILDSEM-----NPCPpgvAGELLIGG 852
Cdd:PTZ00216   439 pLSAATQEFvnvvfgmviqgWGLTETVCCGGIQRTGDLE-PNAVGQLLKGVeMKLLDTEEykhtdTPEP---RGEILLRG 514

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2183974163  853 DGLARGYHRRPGLTAERFLPDPFaadgsrlYRTGDLARYRADGVIEYLGRI 903
Cdd:PTZ00216   515 PFLFKGYYKQEELTREVLDEDGW-------FHTGDVGSIAANGTLRIIGRV 558

hsFATP2a_ACSVL_like

cd05938

Fatty acid transport proteins (FATP) including hsFATP2, hsFATP5, and hsFATP6, and similar ...

1589-1805

2.65e-05

Pssm-ID: 341261 [Multi-domain] Cd Length: 537 Bit Score: 49.98 E-value: 2.65e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1589 YGERALDYGELNLRANRLAHRLI-ELGVGPDVLVGLAAERSLEMIVGLLAILKAGGAYVPLDPRYPSDRLGYMIEDSGIR 1667
Cdd:cd05938      1 FEGETYTYRDVDRRSNQAARALLaHAGLRPGDTVALLLGNEPAFLWIWLGLAKLGCPVAFLNTNIRSKSLLHCFRCCGAK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1668 LLLTQRAARERLPlgEGLPCLLLDAEHEWAGYPESDPQsavGVDNL-------------------------AYVIYTSGS 1722
Cdd:cd05938     81 VLVVAPELQEAVE--EVLPALRADGVSVWYLSHTSNTE---GVISLldkvdaasdepvpaslrahvtikspALYIYTSGT 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1723 TGKPKGTLLPHGNVLRLfDATRHWFGFSADD----AWSLFHSYAFdfsVWEIFGALLHGGRLVIVP-YETSRSPEDflrl 1797
Cdd:cd05938    156 TGLPKAARISHLRVLQC-SGFLSLCGVTADDviyiTLPLYHSSGF---LLGIGGCIELGATCVLKPkFSASQFWDD---- 227


                   ....*....
gi 2183974163 1798 lCRE-RVTV 1805
Cdd:cd05938    228 -CRKhNVTV 235

PRK12582

acyl-CoA synthetase; Provisional

3109-3169

2.73e-05

acyl-CoA synthetase; Provisional

Pssm-ID: 237144 [Multi-domain] Cd Length: 624 Bit Score: 50.04 E-value: 2.73e-05

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2183974163 3109 ERLDYAELNRRANRLAHALIERGIGADRLVGVAMERSIEMVVALMAILKAGGAYVPVDPEY 3169
Cdd:PRK12582    79 RKVTYGEAKRAVDALAQALLDLGLDPGRPVMILSGNSIEHALMTLAAMQAGVPAAPVSPAY 139

PRK12467

peptide synthase; Provisional

56-401

2.73e-05

peptide synthase; Provisional

Pssm-ID: 237108 [Multi-domain] Cd Length: 3956 Bit Score: 50.54 E-value: 2.73e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163   56 RQWFLWQMDPQSAAYNIPSALRLRGELDVEALSASLGAIVERHQSLRTVFVEDeqldgfrqqvlasvdvPVPVTLAGDDd 135
Cdd:PRK12467  3657 RDLMSAPTIAELAGYSPLGDVPVNLLLDLNRLETGFPALFCRHEGLGTVFDYE----------------PLAVILEGDR- 3719

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  136 aqaqirafvesetqqpfdlrngpllrarllrlaaddHVLTLTIHHVAADGWSmrvlveelialygarrqgiEATLPDLPI 215
Cdd:PRK12467  3720 ------------------------------------HVLGLTCRHLLDDGWQ-------------------DTSLQAMAV 3744

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  216 QYADYAIWQRHWLEAGERErqleyWmaRLGGgqsvlelptdrqrpalpsyrgarhelqlpqALGRQLQALAQREGttlfm 295
Cdd:PRK12467  3745 QYADYILWQQAKGPYGLLG-----W--SLGG------------------------------TLARLVAELLEREG----- 3782

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163  296 lllasfqallhrysgqdeirvgvpvanrnrvETERLIGFFVNTQVLRADLDAQMPFLDLLQQtrVAALGAQSHQDL---- 371
Cdd:PRK12467  3783 -------------------------------ESEAFLGLFDNTLPLPDEFVPQAEFLELLRQ--LGELIGRANRLLrgle 3829

                          330       340       350
                   ....*....|....*....|....*....|....*
gi 2183974163  372 -----PFEQLVEALQPERSLSHSPLFQAMYNHQNL 401
Cdd:PRK12467  3830 eggvgPDVLVGIAIQRCFDIAPLELYTPLLDAGEL 3864

PRK07445

O-succinylbenzoic acid--CoA ligase; Reviewed

1773-2082

2.95e-05

O-succinylbenzoic acid--CoA ligase; Reviewed

Pssm-ID: 236019 [Multi-domain] Cd Length: 452 Bit Score: 49.61 E-value: 2.95e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1773 ALLHGGRLVIVPY-------ETSRSPEDFlrllcrervtVLNQTPSAFKQLMQVAcagqeVPPLALRHVVFGGEAlevqa 1845
Cdd:PRK07445   181 SFLTGGKLVILPYkrlksgqELPPNPSDF----------FLSLVPTQLQRLLQLR-----PQWLAQFRTILLGGA----- 240

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1846 lRPWFERFgDRAP----RLVNMYGITETTVHV-TYRPlslAD-LDGGAASpiGEPIPDlswylldAGLNpVPRGCIGELY 1919
Cdd:PRK07445   241 -PAWPSLL-EQARqlqlRLAPTYGMTETASQIaTLKP---DDfLAGNNSS--GQVLPH-------AQIT-IPANQTGNIT 305

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 1920 VGGAGLARGYLnrPELSCTRfvadpfsttggRLYRTGDLARYRCDGVVEYVGRIDHQVKIRGFRIELGEIEARLLAQPGV 1999
Cdd:PRK07445   306 IQAQSLALGYY--PQILDSQ-----------GIFETDDLGYLDAQGYLHILGRNSQKIITGGENVYPAEVEAAILATGLV 372

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2000 AEAVVLphegpG-ATQLVGYVVTQAA-PSDPAALRDTLRQALKASLPEHMVPAHLLFLERLPLTANGKLDRRALPAPDAS 2077
Cdd:PRK07445   373 QDVCVL-----GlPDPHWGEVVTAIYvPKDPSISLEELKTAIKDQLSPFKQPKHWIPVPQLPRNPQGKINRQQLQQIAVQ 447


                   ....*
gi 2183974163 2078 RLQRD 2082
Cdd:PRK07445   448 RLGLP 452

X-Domain_NRPS

X-domain is a catalytically inactive Condensation-like domain shown to recruit oxygenases to ...

2736-2923

5.64e-05

Pssm-ID: 380468 [Multi-domain] Cd Length: 440 Bit Score: 48.63 E-value: 5.64e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2736 GEAGLGFELAEAPLLRLVLVRTGERRHHLIYTNHHILMDGWSNSQLLGEVLQRY----RGETPSRSDG--RYRDYIAWLQ 2809
Cdd:cd19546     99 DRAAHLFDLTRETPWRCTLFALSDTEHVLLLVVHRIAADDESLDVLVRDLAAAYgarrEGRAPERAPLplQFADYALWER 178

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183974163 2810 RQDAGRTE---------AFWKQRLQRLGEPTLLVPAFAHGVRGAEGHADRYRQLDVTTSQRLAEFAREQKVTLNTLVQAA 2880
Cdd:cd19546    179 ELLAGEDDrdsligdqiAYWRDALAGAPDELELPTDRPRPVLPSRRAGAVPLRLDAEVHARLMEAAESAGATMFTVVQAA 258

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 2183974163 2881 WLILLQRFTGQDTVAFGaTVSGRPAELRGIEEQIGLFINTLPV 2923
Cdd:cd19546    259 LAMLLTRLGAGTDVTVG-TVLPRDDEEGDLEGMVGPFARPLAL 300

C_NRPS-like