NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2184758456|ref|WP_236374796|]
View 

bifunctional 2-polyprenyl-6-hydroxyphenol methylase/3-demethylubiquinol 3-O-methyltransferase UbiG [Pseudomonas salomonii]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 11454890)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

EC:  2.1.1.-
Gene Ontology:  GO:0032259|GO:0008168|GO:1904047
PubMed:  12504684|12826405

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 33-157 2.33e-21

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


:

Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 86.22  E-value: 2.33e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184758456  33 WEKRkageqgfFEQLLKSHGV--KSVLDVSTGSGFHAVQLKQAGFEVVATDGSGTMLNKARQNFleRKLAIESHHKEWLE 110
Cdd:COG2227    10 WDRR-------LAALLARLLPagGRVLDVGCGTGRLALALARRGADVTGVDISPEALEIARERA--AELNVDFVQGDLED 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2184758456 111 LDPDmLGTFDAVVCLGsSLCHVfeaSDRMSVLRTFRALLKPGGVLIV 157
Cdd:COG2227    81 LPLE-DGSFDLVICSE-VLEHL---PDPAALLRELARLLKPGGLLLL 122
 
Name Accession Description Interval E-value
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 33-157 2.33e-21

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 86.22  E-value: 2.33e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184758456  33 WEKRkageqgfFEQLLKSHGV--KSVLDVSTGSGFHAVQLKQAGFEVVATDGSGTMLNKARQNFleRKLAIESHHKEWLE 110
Cdd:COG2227    10 WDRR-------LAALLARLLPagGRVLDVGCGTGRLALALARRGADVTGVDISPEALEIARERA--AELNVDFVQGDLED 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2184758456 111 LDPDmLGTFDAVVCLGsSLCHVfeaSDRMSVLRTFRALLKPGGVLIV 157
Cdd:COG2227    81 LPLE-DGSFDLVICSE-VLEHL---PDPAALLRELARLLKPGGLLLL 122
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 56-153 1.00e-17

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 75.68  E-value: 1.00e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184758456  56 VLDVSTGSGFHAVQL-KQAGFEVVATDGSGTMLNKARQNFLERKLAIESHHKEWLELDPDmLGTFDAVVCLGsSLCHvFE 134
Cdd:pfam13649   1 VLDLGCGTGRLTLALaRRGGARVTGVDLSPEMLERARERAAEAGLNVEFVQGDAEDLPFP-DGSFDLVVSSG-VLHH-LP 77

                          90
                  ....*....|....*....
gi 2184758456 135 ASDRMSVLRTFRALLKPGG 153
Cdd:pfam13649  78 DPDLEAALREIARVLKPGG 96
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 56-157 1.64e-09

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 53.97  E-value: 1.64e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184758456  56 VLDVSTGSGFHAVQLKQAGF-EVVATDGSGTMLNKARQNFLERKLA-IESHHKEWLELDPDMLGTFDAVVCLGSsLCHVF 133
Cdd:cd02440     2 VLDLGCGTGALALALASGPGaRVTGVDISPVALELARKAAAALLADnVEVLKGDAEELPPEADESFDVIISDPP-LHHLV 80

                          90       100
                  ....*....|....*....|....
gi 2184758456 134 EasDRMSVLRTFRALLKPGGVLIV 157
Cdd:cd02440    81 E--DLARFLEEARRLLKPGGVLVL 102
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 33-157 4.50e-07

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 49.38  E-value: 4.50e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184758456  33 WeKRKAgeqgfFEQLLKSHGVKsVLDVSTGSGFHAVQL-KQAG--FEVVATDGSGTMLNKARQNFLERKLaieSHHKEWL 109
Cdd:PRK00216   39 W-RRKT-----IKWLGVRPGDK-VLDLACGTGDLAIALaKAVGktGEVVGLDFSEGMLAVGREKLRDLGL---SGNVEFV 108

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2184758456 110 ELD------PDmlGTFDAV-VCLGssLCHVfeaSDRMSVLRTFRALLKPGGVLIV 157
Cdd:PRK00216  109 QGDaealpfPD--NSFDAVtIAFG--LRNV---PDIDKALREMYRVLKPGGRLVI 156
 
Name Accession Description Interval E-value
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 33-157 2.33e-21

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 86.22  E-value: 2.33e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184758456  33 WEKRkageqgfFEQLLKSHGV--KSVLDVSTGSGFHAVQLKQAGFEVVATDGSGTMLNKARQNFleRKLAIESHHKEWLE 110
Cdd:COG2227    10 WDRR-------LAALLARLLPagGRVLDVGCGTGRLALALARRGADVTGVDISPEALEIARERA--AELNVDFVQGDLED 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2184758456 111 LDPDmLGTFDAVVCLGsSLCHVfeaSDRMSVLRTFRALLKPGGVLIV 157
Cdd:COG2227    81 LPLE-DGSFDLVICSE-VLEHL---PDPAALLRELARLLKPGGLLLL 122
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 46-157 5.96e-19

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 80.42  E-value: 5.96e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184758456  46 QLLKSHGVKSVLDVSTGSGFHAVQLKQAGFEVVATDGSGTMLNKARQNFLERKLAIESHHKEWLELD-PDmlGTFDAVVC 124
Cdd:COG2226    16 AALGLRPGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELARERAAEAGLNVEFVVGDAEDLPfPD--GSFDLVIS 93

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2184758456 125 LGsSLCHVfeaSDRMSVLRTFRALLKPGGVLIV 157
Cdd:COG2226    94 SF-VLHHL---PDPERALAEIARVLKPGGRLVV 122
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 56-153 1.00e-17

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 75.68  E-value: 1.00e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184758456  56 VLDVSTGSGFHAVQL-KQAGFEVVATDGSGTMLNKARQNFLERKLAIESHHKEWLELDPDmLGTFDAVVCLGsSLCHvFE 134
Cdd:pfam13649   1 VLDLGCGTGRLTLALaRRGGARVTGVDLSPEMLERARERAAEAGLNVEFVQGDAEDLPFP-DGSFDLVVSSG-VLHH-LP 77

                          90
                  ....*....|....*....
gi 2184758456 135 ASDRMSVLRTFRALLKPGG 153
Cdd:pfam13649  78 DPDLEAALREIARVLKPGG 96
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
22-158 1.01e-15

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 72.72  E-value: 1.01e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184758456  22 DFVERWDALIDWEKRKAGEQGFFEQLLKSHG---VKSVLDVSTGSGFHAVQLKQAGFEVVATDGSGTMLNKARQNFLERK 98
Cdd:COG4976    13 QYADSYDAALVEDLGYEAPALLAEELLARLPpgpFGRVLDLGCGTGLLGEALRPRGYRLTGVDLSEEMLAKAREKGVYDR 92

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184758456  99 LaiesHHKEWLELdPDMLGTFDAVVCLGsSLCHVfeaSDRMSVLRTFRALLKPGGVLIVD 158
Cdd:COG4976    93 L----LVADLADL-AEPDGRFDLIVAAD-VLTYL---GDLAAVFAGVARALKPGGLFIFS 143
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 18-157 2.58e-15

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 71.11  E-value: 2.58e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184758456  18 QYSPDFVERWDALIDwekrkAGEQGFFEQLLKSHGVK---SVLDVSTGSGFHAVQL-KQAGFEVVATDGSGTMLNKARQN 93
Cdd:COG2230    19 TYSCAYFEDPDDTLE-----EAQEAKLDLILRKLGLKpgmRVLDIGCGWGGLALYLaRRYGVRVTGVTLSPEQLEYARER 93

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2184758456  94 FLERKLA--IESHHKEWLELDPDmlGTFDAVVCLGSsLCHVFEAsDRMSVLRTFRALLKPGGVLIV 157
Cdd:COG2230    94 AAEAGLAdrVEVRLADYRDLPAD--GQFDAIVSIGM-FEHVGPE-NYPAYFAKVARLLKPGGRLLL 155
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 33-173 6.57e-15

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 71.10  E-value: 6.57e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184758456  33 WEKRKAGEQ-----GFFEQLLKSHGVKSVLDVSTGSGFHAVQLKQA-GFEVVATDGSGTMLNKARQNFLERKLA-IESHH 105
Cdd:COG0500     2 WDSYYSDELlpglaALLALLERLPKGGRVLDLGCGTGRNLLALAARfGGRVIGIDLSPEAIALARARAAKAGLGnVEFLV 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2184758456 106 KEWLELDPDMLGTFDAVVCLGSSlcHVFEASDRMSVLRTFRALLKPGGVLIV-----DQRNFRAIRAGNFKSS 173
Cdd:COG0500    82 ADLAELDPLPAESFDLVVAFGVL--HHLPPEEREALLRELARALKPGGVLLLsasdaAAALSLARLLLLATAS 152
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
55-158 1.78e-13

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 64.46  E-value: 1.78e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184758456  55 SVLDVSTGSGFHAVQLKQA--GFEVVATDGSGTMLNKARQNFLErklaIESHHKEWLELDPDmlGTFDAVVClGSSLCHV 132
Cdd:COG4106     4 RVLDLGCGTGRLTALLAERfpGARVTGVDLSPEMLARARARLPN----VRFVVADLRDLDPP--EPFDLVVS-NAALHWL 76

                          90       100
                  ....*....|....*....|....*.
gi 2184758456 133 feaSDRMSVLRTFRALLKPGGVLIVD 158
Cdd:COG4106    77 ---PDHAALLARLAAALAPGGVLAVQ 99
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 57-157 2.43e-13

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 64.22  E-value: 2.43e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184758456  57 LDVSTGSGFHAVQLKQAGFEVVATDGSGTMLNKARQNFLERKLaieshhkEWLELDPDML----GTFDAVVCLGsSLCHV 132
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELAREKAPREGL-------TFVVGDAEDLpfpdNSFDLVLSSE-VLHHV 72

                          90       100
                  ....*....|....*....|....*
gi 2184758456 133 feaSDRMSVLRTFRALLKPGGVLIV 157
Cdd:pfam08241  73 ---EDPERALREIARVLKPGGILII 94
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 57-155 9.12e-11

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 57.38  E-value: 9.12e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184758456  57 LDVSTGSGF--HAVQLKQAGFEVVATDGSGTMLNKARQNFLERKLAIESHHkEWLELDPD--MLGTFDAVVCLGSsLCHV 132
Cdd:pfam08242   1 LEIGCGTGTllRALLEALPGLEYTGLDISPAALEAARERLAALGLLNAVRV-ELFQLDLGelDPGSFDVVVASNV-LHHL 78

                          90       100
                  ....*....|....*....|...
gi 2184758456 133 FeasDRMSVLRTFRALLKPGGVL 155
Cdd:pfam08242  79 A---DPRAVLRNIRRLLKPGGVL 98
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 56-157 1.64e-09

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 53.97  E-value: 1.64e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184758456  56 VLDVSTGSGFHAVQLKQAGF-EVVATDGSGTMLNKARQNFLERKLA-IESHHKEWLELDPDMLGTFDAVVCLGSsLCHVF 133
Cdd:cd02440     2 VLDLGCGTGALALALASGPGaRVTGVDISPVALELARKAAAALLADnVEVLKGDAEELPPEADESFDVIISDPP-LHHLV 80

                          90       100
                  ....*....|....*....|....
gi 2184758456 134 EasDRMSVLRTFRALLKPGGVLIV 157
Cdd:cd02440    81 E--DLARFLEEARRLLKPGGVLVL 102
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 40-158 1.01e-08

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 53.26  E-value: 1.01e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184758456  40 EQG-FFEQLLKSHGVKSVLDVSTGSGFHAVQLKQA---GFEVVATDGSGTMLNKARQNFLERKLA--IESHHKEWLELDP 113
Cdd:COG4122     3 EQGrLLYLLARLLGAKRILEIGTGTGYSTLWLARAlpdDGRLTTIEIDPERAAIARENFARAGLAdrIRLILGDALEVLP 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2184758456 114 DML-GTFDAVVCLG--SSLCHVFEASDRmsvlrtfraLLKPGGVLIVD 158
Cdd:COG4122    83 RLAdGPFDLVFIDAdkSNYPDYLELALP---------LLRPGGLIVAD 121
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 54-157 2.19e-07

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 49.35  E-value: 2.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184758456  54 KSVLDVSTGSGFHAVQLKQAGFEVVATDGSGTMLNKARQNFlerklaieSHHKEWLELDPDMLGTFDAVVCLGsSLCHVf 133
Cdd:pfam13489  24 GRVLDFGCGTGIFLRLLRAQGFSVTGVDPSPIAIERALLNV--------RFDQFDEQEAAVPAGKFDVIVARE-VLEHV- 93

                          90       100
                  ....*....|....*....|....
gi 2184758456 134 eaSDRMSVLRTFRALLKPGGVLIV 157
Cdd:pfam13489  94 --PDPPALLRQIAALLKPGGLLLL 115
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 33-157 4.50e-07

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 49.38  E-value: 4.50e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184758456  33 WeKRKAgeqgfFEQLLKSHGVKsVLDVSTGSGFHAVQL-KQAG--FEVVATDGSGTMLNKARQNFLERKLaieSHHKEWL 109
Cdd:PRK00216   39 W-RRKT-----IKWLGVRPGDK-VLDLACGTGDLAIALaKAVGktGEVVGLDFSEGMLAVGREKLRDLGL---SGNVEFV 108

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2184758456 110 ELD------PDmlGTFDAV-VCLGssLCHVfeaSDRMSVLRTFRALLKPGGVLIV 157
Cdd:PRK00216  109 QGDaealpfPD--NSFDAVtIAFG--LRNV---PDIDKALREMYRVLKPGGRLVI 156
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 1-157 8.91e-07

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 48.62  E-value: 8.91e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184758456   1 MSQILGYEHEE-VANYLTQYSPDFVERWDALidWEKRKAGE--------QGFF-----------------EQL------- 47
Cdd:PRK09328   26 LAHVLGLSRTDlLLNPEEELTPEELERFRAL--VARRAAGEplqyilgeAEFWgldfkvspgvliprpetEELvewalea 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184758456  48 LKSHGVKSVLDVSTGSGFHAVQLKQA--GFEVVATDGSGTMLNKARQNFLERKLA-IESHHKEWLEldPDMLGTFDAVVC 124
Cdd:PRK09328  104 LLLKEPLRVLDLGTGSGAIALALAKErpDAEVTAVDISPEALAVARRNAKHGLGArVEFLQGDWFE--PLPGGRFDLIVS 181

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2184758456 125 -------------LGSSLCH-----VFEASDRMSVLRTF----RALLKPGGVLIV 157
Cdd:PRK09328  182 nppyipeadihllQPEVRDHephlaLFGGEDGLDFYRRIieqaPRYLKPGGWLLL 236
PRK07580 PRK07580
Mg-protoporphyrin IX methyl transferase; Validated
 54-131 1.91e-06

Mg-protoporphyrin IX methyl transferase; Validated


Pssm-ID: 236059 [Multi-domain]  Cd Length: 230  Bit Score: 47.52  E-value: 1.91e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184758456  54 KSVLDVSTGSGFHAVQLKQAGFEVVATDGSGTMLNKARQnflERKLAIESHHKEWL--ELDPDmLGTFDAVVCLgSSLCH 131
Cdd:PRK07580   65 LRILDAGCGVGSLSIPLARRGAKVVASDISPQMVEEARE---RAPEAGLAGNITFEvgDLESL-LGRFDTVVCL-DVLIH 139
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 54-177 1.99e-06

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 46.26  E-value: 1.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184758456  54 KSVLDVSTGSGFHAVQL-KQAGF--EVVATDGSGTMLNKARQNFLERKLA-IESHHKEWLELDPDM-LGTFDaVVCLGSS 128
Cdd:pfam13847   5 MRVLDLGCGTGHLSFELaEELGPnaEVVGIDISEEAIEKARENAQKLGFDnVEFEQGDIEELPELLeDDKFD-VVISNCV 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2184758456 129 LCHVFeasDRMSVLRTFRALLKPGGVLIVDQRNFRAIRAGNFKSSGNYY 177
Cdd:pfam13847  84 LNHIP---DPDKVLQEILRVLKPGGRLIISDPDSLAELPAHVKEDSTYY 129
Nnt1 COG3897
Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, ...
 54-158 7.02e-06

Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443104 [Multi-domain]  Cd Length: 216  Bit Score: 45.65  E-value: 7.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184758456  54 KSVLDVSTGSGFHAVQLKQAGF-EVVATDGSGTMLNKARQNFLERKLAIESHHKEWLELDPDmlGTFDAVvcLGSSLChv 132
Cdd:COG3897    72 KRVLELGCGLGLVGIAAAKAGAaDVTATDYDPEALAALRLNAALNGVAITTRLGDWRDPPAA--GGFDLI--LGGDVL-- 145

                          90       100
                  ....*....|....*....|....*..
gi 2184758456 133 FEASDRMSVLRTFRALLKPGG-VLIVD 158
Cdd:COG3897   146 YERDLAEPLLPFLDRLAAPGGeVLIGD 172
PRK14967 PRK14967
putative methyltransferase; Provisional
 56-173 1.21e-05

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 45.04  E-value: 1.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184758456  56 VLDVSTGSGFHAVQLKQAG-FEVVATDGSGTMLNKARQNFLERKLAIESHHKEWLELDPDmlGTFDAVVClgsSLCHVFE 134
Cdd:PRK14967   40 VLDLCTGSGALAVAAAAAGaGSVTAVDISRRAVRSARLNALLAGVDVDVRRGDWARAVEF--RPFDVVVS---NPPYVPA 114

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2184758456 135 ASDRMSVLRTFRA--------------------LLKPGGVLIVDQ-------RNFRAIRAGNFKSS 173
Cdd:PRK14967  115 PPDAPPSRGPARAwdagpdgravldrlcdaapaLLAPGGSLLLVQselsgveRTLTRLSEAGLDAE 180
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
55-157 1.67e-04

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 41.66  E-value: 1.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184758456  55 SVLDVSTGSG---FHAVQLKQAGFEVVATDGSGTMLNKARQNFLER-KLAIESHHKEWLELdPDMLGTFDaVVCLGSSLC 130
Cdd:pfam01209  45 KFLDVAGGTGdwtFGLSDSAGSSGKVVGLDINENMLKEGEKKAKEEgKYNIEFLQGNAEEL-PFEDDSFD-IVTISFGLR 122

                          90       100
                  ....*....|....*....|....*..
gi 2184758456 131 HVfeaSDRMSVLRTFRALLKPGGVLIV 157
Cdd:pfam01209 123 NF---PDYLKVLKEAFRVLKPGGRVVC 146
CheR COG1352
Methylase of chemotaxis methyl-accepting proteins [Signal transduction mechanisms];
69-157 1.40e-03

Methylase of chemotaxis methyl-accepting proteins [Signal transduction mechanisms];


Pssm-ID: 440963 [Multi-domain]  Cd Length: 272  Bit Score: 38.99  E-value: 1.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184758456  69 QLKQAGFEVVATDGSGTMLNKARQ-------------NFLE----------------RKLAIESHHkeWLELDPDMLGTF 119
Cdd:COG1352   130 ELAGWRVEILATDISEEALEKARAgiyperslrglppEYLSryftkeggryrikpelREMVTFAQH--NLLDDPPPFGRF 207

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2184758456 120 DAVVClgsslCHV---FEASDRMSVLRTFRALLKPGGVLIV 157
Cdd:COG1352   208 DLIFC-----RNVliyFDPELQRRVLRRFHDSLAPGGYLFL 243
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 20-124 2.30e-03

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 38.59  E-value: 2.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184758456  20 SPDFVERWDALIdwEKRKA--------GEQGFF-----------------EQL-------LKSHGVKSVLDVSTGSGFHA 67
Cdd:COG2890    50 TEEELARLEALV--ARRAAgeplayilGEAEFYglefkvdpgvliprpetEELvelalalLPAGAPPRVLDLGTGSGAIA 127

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2184758456  68 VQLKQA--GFEVVATDGSGTMLNKARQNFLERKLA--IESHHKEWLELDPDmLGTFDAVVC 124
Cdd:COG2890   128 LALAKErpDARVTAVDISPDALAVARRNAERLGLEdrVRFLQGDLFEPLPG-DGRFDLIVS 187
PRK08317 PRK08317
hypothetical protein; Provisional
 55-157 3.39e-03

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 37.99  E-value: 3.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184758456  55 SVLDVSTGSGFHAVQLKQA---GFEVVATDGSGTMLNKARQNFLERKLAIESHHKEWLELD-PDmlGTFDAVVclgssLC 130
Cdd:PRK08317   22 RVLDVGCGPGNDARELARRvgpEGRVVGIDRSEAMLALAKERAAGLGPNVEFVRGDADGLPfPD--GSFDAVR-----SD 94

                          90       100
                  ....*....|....*....|....*...
gi 2184758456 131 HVFE-ASDRMSVLRTFRALLKPGGVLIV 157
Cdd:PRK08317   95 RVLQhLEDPARALAEIARVLRPGGRVVV 122
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
17-156 5.25e-03

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 37.32  E-value: 5.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184758456  17 TQYSPDFVERW-DALIDWEKRKAGeqgfFEQLLKSHGV--KSVLDVSTGSGFHAVQLKQAGFE-VVATDGSGTMLNKARQ 92
Cdd:COG4076     1 DYLMQFFVPRWhHPMLNDVERNDA----FKAAIERVVKpgDVVLDIGTGSGLLSMLAARAGAKkVYAVEVNPDIAAVARR 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2184758456  93 NFLERKLA--IESHHKEWLELDPDmlGTFDAVVC--LGSSLChvfeASDRMSVLRTFRA-LLKPGGVLI 156
Cdd:COG4076    77 IIAANGLSdrITVINADATDLDLP--EKADVIISemLDTALL----DEGQVPILNHARKrLLKPGGRII 139
PRK14968 PRK14968
putative methyltransferase; Provisional
 54-81 6.42e-03

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 36.80  E-value: 6.42e-03
                          10        20
                  ....*....|....*....|....*...
gi 2184758456  54 KSVLDVSTGSGFHAVQLKQAGFEVVATD 81
Cdd:PRK14968   25 DRVLEVGTGSGIVAIVAAKNGKKVVGVD 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH