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Conserved domains on  [gi|2189429128|ref|WP_237385957|]
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ROK family protein [Xenorhabdus sp. Sc-CR9]

Protein Classification

actin family protein( domain architecture ID 229483)

actin family protein similar to Caldicellulosiruptor bescii xylose repressor, a transcriptional repressor of xylose-utilizing enzymes

CATH:  3.30.420.40
Gene Ontology:  GO:0000166|GO:0003677
PubMed:  8800467|7781919
SCOP:  3000092

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ASKHA_ATPase-like super family cl49607
ATPase-like domain of the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily; The ASKHA ...
 87-401 1.74e-165

ATPase-like domain of the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily; The ASKHA superfamily, also known as actin-like ATPase domain superfamily, includes acetate and sugar kinases, heat-shock cognate 70 (Hsp70) and actin family proteins. They either function as conformational hydrolases (e.g. Hsp70, actin) that perform simple ATP hydrolysis, or as metabolite kinases (e.g. glycerol kinase) that catalyze the transfer of a phosphoryl group from ATP to their cognate substrates. Both activities depend on the presence of specific metal cations. ASKHA superfamily members share a common core fold that includes an actin-like ATPase domain consisting of two subdomains (denoted I _ II) with highly similar ribonuclease (RNase) H-like folds. The fold of each subdomain is characterized by a central five strand beta-sheet and flanking alpha-helices. The two subdomains form an active site cleft in which ATP binds at the bottom. Another common feature of ASKHA superfamily members is the coupling of phosphoryl-group transfer to conformational rearrangement, leading to domain closure. Substrate binding triggers protein motion.


The actual alignment was detected with superfamily member cd24075:

Pssm-ID: 483947 [Multi-domain]  Cd Length: 315  Bit Score: 466.46  E-value: 1.74e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128  87 FHTIGIRLGRHDATLALFDMSGKTLTEERYAILENTQQEVEKRIISAIESFIDQNQRRIRELIAISVIIPGLVDPDEGII 166
Cdd:cd24075     1 FHILAVRLGRHDLTLGLYDLSGELLAEHTVPLTALNQEALLSQLIEEIAQFLKSHRRKTQRLIAISITLPGLINPKTGVV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 167 RYMPHIKVDNWPLVYNLKNHFKTFCFIGHDIRSLALAENYFGATRDCEDSILVRIHRGTGAGVIVNNNILLNKRGNLGEI 246
Cdd:cd24075    81 HYMPHIQVKSWPIVEELEQRFNVPCFIGNDIRSLALAEHYFGASKDCKDSILVRIHHGIGAGIIIDGKLFLGQNGNAGEI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 247 GHIQIEPLGERCHCGNFGCLETIVSNSAIETRVQHQLRQGFPSQLTLNNCNIHAICLAANAGDPLATEIIRQAGHYLGKA 326
Cdd:cd24075   161 GHIQIEPLGERCHCGNFGCLETVASNAAIEQRVKKLLKQGYASQLTLQDCTIKDICQAALNGDQLAQDVIKRAGRYLGKV 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2189429128 327 ISITINLFNPQKVVIAGEIAEAKQVLLPAIQNCINKQVLKAFREELPVVVSELNHCSAIGAFALTKRAMLNGVLL 401
Cdd:cd24075   241 IAILINLLNPQKIIIAGEITQADKVLLPVIKKCIQSQALPDFRQELKIVASQLDHNSAIGAFALVKRALLEGGLL 315
HTH_ARSR super family cl46857
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 26-88 1.53e-06

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


The actual alignment was detected with superfamily member smart00347:

Pssm-ID: 481197 [Multi-domain]  Cd Length: 101  Bit Score: 46.43  E-value: 1.53e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2189429128   26 RLIDQHGPISRIQIAEESQLAPASVTKITRQLLERGLIkevEHQASTGGRRA--ISIVTESRHFH 88
Cdd:smart00347  17 RILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLV---RREPSPEDRRSvlVSLTEEGRELI 78
 
Name Accession Description Interval E-value
ASKHA_ATPase_ROK_NagC cd24075
ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as ...
 87-401 1.74e-165

ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as a repressor of the nagEBACD operon involved in the uptake and degradation of the amino sugars, N-acetyl-D-glucosamine (GlcNAc) and glucosamine (GlcN). It acts both as an activator and a repressor for the transcription of the glmSU operon, encoding proteins necessary for the synthesis of GlcN (glmS) and the formation of UDP-GlcNAc (glmU). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466925 [Multi-domain]  Cd Length: 315  Bit Score: 466.46  E-value: 1.74e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128  87 FHTIGIRLGRHDATLALFDMSGKTLTEERYAILENTQQEVEKRIISAIESFIDQNQRRIRELIAISVIIPGLVDPDEGII 166
Cdd:cd24075     1 FHILAVRLGRHDLTLGLYDLSGELLAEHTVPLTALNQEALLSQLIEEIAQFLKSHRRKTQRLIAISITLPGLINPKTGVV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 167 RYMPHIKVDNWPLVYNLKNHFKTFCFIGHDIRSLALAENYFGATRDCEDSILVRIHRGTGAGVIVNNNILLNKRGNLGEI 246
Cdd:cd24075    81 HYMPHIQVKSWPIVEELEQRFNVPCFIGNDIRSLALAEHYFGASKDCKDSILVRIHHGIGAGIIIDGKLFLGQNGNAGEI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 247 GHIQIEPLGERCHCGNFGCLETIVSNSAIETRVQHQLRQGFPSQLTLNNCNIHAICLAANAGDPLATEIIRQAGHYLGKA 326
Cdd:cd24075   161 GHIQIEPLGERCHCGNFGCLETVASNAAIEQRVKKLLKQGYASQLTLQDCTIKDICQAALNGDQLAQDVIKRAGRYLGKV 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2189429128 327 ISITINLFNPQKVVIAGEIAEAKQVLLPAIQNCINKQVLKAFREELPVVVSELNHCSAIGAFALTKRAMLNGVLL 401
Cdd:cd24075   241 IAILINLLNPQKIIIAGEITQADKVLLPVIKKCIQSQALPDFRQELKIVASQLDHNSAIGAFALVKRALLEGGLL 315
ROK pfam00480
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ...
 90-393 1.11e-88

ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.


Pssm-ID: 395384 [Multi-domain]  Cd Length: 292  Bit Score: 270.37  E-value: 1.11e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128  90 IGIRLGRHDATLALFDMSGKTLTEERYailENTQQEVEKRIISAIESFIDQNQRRIRELIAISVIIPGLVDPDEGIIRYM 169
Cdd:pfam00480   1 IGIDIGGTKIAAALFDEEGEILARERV---PTPTTTTEETLVDAIAFFVDSAQRKFGELIAVGIGSPGLISPKYGYITNT 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 170 PHIKVDNWPLVYNLKNHFKTFCFIGHDIRSLALAENYFGATRDCEDSILVRIHRGTGAGVIVNNNILLNKRGNLGEIGHI 249
Cdd:pfam00480  78 PNIGWDNFDLVEKLEERFNVPVFFENDANAAALAEAVFGASKDVQNVIYVTVGTGVGGGVISNGKLFTGRNGVAGEIGHI 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 250 QIEPLGERCHCGNFGCLETIVSNSAIETRVQHQLRqgfpsqltlnNCNIHAICLAANAGDPLATEIIRQAGHYLGKAISI 329
Cdd:pfam00480 158 QLDPNGPKCGCGNHGCLETIASGRALEKRYQQKGE----------DLEGKDIIVLAEQGDEVAEEAVERLARYLAKAIAN 227

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2189429128 330 TINLFNPQKVVIAGEIAEAKQvLLPAIQNCINKQVLKAFRE--ELPVVVSELNHCSAIGAFALTKR 393
Cdd:pfam00480 228 LINLFDPQAIVLGGGVSNADG-LLEAIRSLVKKYLNGYLPVppVIIVAASLGDNAGALGAAALAKQ 292
NagC COG1940
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ...
 86-390 1.47e-84

Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];


Pssm-ID: 441543 [Multi-domain]  Cd Length: 306  Bit Score: 260.21  E-value: 1.47e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128  86 HFHTIGIRLGRHDATLALFDMSGKTLTEERYAI-LENTQQEVEKRIISAIESFIDQNQRRIRELIAISVIIPGLVDPDEG 164
Cdd:COG1940     4 AGYVIGIDIGGTKIKAALVDLDGEVLARERIPTpAGAGPEAVLEAIAELIEELLAEAGISRGRILGIGIGVPGPVDPETG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 165 IIRYMPHIK-VDNWPLVYNLKNHFKTFCFIGHDIRSLALAENYFGATRDCEDSILVRIHRGTGAGVIVNNNILLNKRGNL 243
Cdd:COG1940    84 VVLNAPNLPgWRGVPLAELLEERLGLPVFVENDANAAALAEAWFGAGRGADNVVYLTLGTGIGGGIVINGKLLRGANGNA 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 244 GEIGHIQIEPLGERCHCGNFGCLETIVSNSAIETRVQHQLRqgfpsqltLNNCNIHAICLAANAGDPLATEIIRQAGHYL 323
Cdd:COG1940   164 GEIGHMPVDPDGPLCGCGNRGCLETYASGPALLRRARELGG--------AEKLTAEELFAAARAGDPLALEVLDEAARYL 235

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2189429128 324 GKAISITINLFNPQKVVIAGEIAEAKQVLLPAIQNCINKQVLKAFREELPVVVSEL-NHCSAIGAFAL 390
Cdd:COG1940   236 GIGLANLINLLDPEVIVLGGGVSAAGDLLLEPIREALAKYALPPAREDPRIVPASLgDDAGLLGAAAL 303
PRK09698 PRK09698
D-allose kinase; Provisional
 90-397 1.14e-23

D-allose kinase; Provisional


Pssm-ID: 182034 [Multi-domain]  Cd Length: 302  Bit Score: 100.06  E-value: 1.14e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128  90 IGIRLGRHDATLALFDMSGKTLTEERYAILENTQQEVEKRIISAIESFIDQNQRRIReliAISVIIPGLVDPDEGIIRYM 169
Cdd:PRK09698    7 LGIDMGGTHIRFCLVDAEGEILHCEKKRTAEVIAPDLVSGLGEMIDEYLRRFNARCH---GIVMGFPALVSKDRRTVIST 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 170 PHIKV---DNWPLVYNLKNHFKTFCFIGHDIRSLALaenYFGATRDCEDSILVRIHRGTGAG--VIVNNNILLNKRGNLG 244
Cdd:PRK09698   84 PNLPLtalDLYDLADKLENTLNCPVFFSRDVNLQLL---WDVKENNLTQQLVLGAYLGTGMGfaVWMNGAPWTGAHGVAG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 245 EIGHIQIEPLGERCHCGNFGCLETIVSNSAIETRVQHQLRQGFPSQLTLnncnihaiclaaNAGDplaTEIIRQAGHYLG 324
Cdd:PRK09698  161 ELGHIPLGDMTQHCGCGNPGCLETNCSGMALRRWYEQQPRDYPLSDLFV------------HAGD---HPFIQSLLENLA 225

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2189429128 325 KAISITINLFNPQKVVIAGEIAEAKQVLLPAIQNCINKQVLKAF-REELPVVVSELN-HCSAIGAFALTKRAMLN 397
Cdd:PRK09698  226 RAIATSINLFDPDAIILGGGVMDMPAFPRETLIAMIQKYLRKPLpYEVVRFIYASSSdFNGAQGAAILAHQRFLP 300
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
26-88 1.53e-06

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 46.43  E-value: 1.53e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2189429128   26 RLIDQHGPISRIQIAEESQLAPASVTKITRQLLERGLIkevEHQASTGGRRA--ISIVTESRHFH 88
Cdd:smart00347  17 RILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLV---RREPSPEDRRSvlVSLTEEGRELI 78
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 23-78 3.82e-06

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 44.08  E-value: 3.82e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2189429128  23 VVYRLIDQHGPISRIQIAEESQLAPASVTKITRQLLERGLIkevEHQASTGGRRAI 78
Cdd:pfam01047   7 HILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLI---ERSRSPEDRREV 59
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
23-86 6.25e-05

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 42.50  E-value: 6.25e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2189429128  23 VVYRLIDQHGPISRIQIAEESQLAPASVTKITRQLLERGLIKEVEHQAST----GGRRAISIVTesRH 86
Cdd:COG1321    14 AIYELSEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEPYGGITlteeGRELALRIVR--RH 79
 
Name Accession Description Interval E-value
ASKHA_ATPase_ROK_NagC cd24075
ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as ...
 87-401 1.74e-165

ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as a repressor of the nagEBACD operon involved in the uptake and degradation of the amino sugars, N-acetyl-D-glucosamine (GlcNAc) and glucosamine (GlcN). It acts both as an activator and a repressor for the transcription of the glmSU operon, encoding proteins necessary for the synthesis of GlcN (glmS) and the formation of UDP-GlcNAc (glmU). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466925 [Multi-domain]  Cd Length: 315  Bit Score: 466.46  E-value: 1.74e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128  87 FHTIGIRLGRHDATLALFDMSGKTLTEERYAILENTQQEVEKRIISAIESFIDQNQRRIRELIAISVIIPGLVDPDEGII 166
Cdd:cd24075     1 FHILAVRLGRHDLTLGLYDLSGELLAEHTVPLTALNQEALLSQLIEEIAQFLKSHRRKTQRLIAISITLPGLINPKTGVV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 167 RYMPHIKVDNWPLVYNLKNHFKTFCFIGHDIRSLALAENYFGATRDCEDSILVRIHRGTGAGVIVNNNILLNKRGNLGEI 246
Cdd:cd24075    81 HYMPHIQVKSWPIVEELEQRFNVPCFIGNDIRSLALAEHYFGASKDCKDSILVRIHHGIGAGIIIDGKLFLGQNGNAGEI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 247 GHIQIEPLGERCHCGNFGCLETIVSNSAIETRVQHQLRQGFPSQLTLNNCNIHAICLAANAGDPLATEIIRQAGHYLGKA 326
Cdd:cd24075   161 GHIQIEPLGERCHCGNFGCLETVASNAAIEQRVKKLLKQGYASQLTLQDCTIKDICQAALNGDQLAQDVIKRAGRYLGKV 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2189429128 327 ISITINLFNPQKVVIAGEIAEAKQVLLPAIQNCINKQVLKAFREELPVVVSELNHCSAIGAFALTKRAMLNGVLL 401
Cdd:cd24075   241 IAILINLLNPQKIIIAGEITQADKVLLPVIKKCIQSQALPDFRQELKIVASQLDHNSAIGAFALVKRALLEGGLL 315
ASKHA_ATPase_ROK_Mlc cd24074
ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies ...
 86-407 5.00e-101

ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies protein, acts as a transcriptional repressor that regulates the expression of proteins that are part of the phosphotransferase system for sugar uptake. It regulates the expression of malT. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466924 [Multi-domain]  Cd Length: 322  Bit Score: 303.08  E-value: 5.00e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128  86 HFHTIGIRLGRHDATLALFDMSGKTLTEERYAILENTQQEVEKRIISAIESFIDQNQRRIRELIAISVIIPGLVDPDEGI 165
Cdd:cd24074     1 GWQFLSIRIGRGYITLALRDLNGRLLAEERYPLPAKDNDPFLDRLLESISEFFSRHQKKLERLTAIAITLPGIIDPESGI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 166 IRYMPHIKVDNWPLVYNLKNHFKTFCFIGHDIRSLALAENYFGATRDCEDSILVRIHRGTGAGVIvNNNILLNKR-GNLG 244
Cdd:cd24074    81 VHRLPFYDIKNLPLGEALEQHTGLPVYVQHDISAWTLAERFFGAAKGAKNIIQIVIDDDIGAGVI-TDGQLLHAGsSRLG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 245 EIGHIQIEPLGERCHCGNFGCLETIVSNSAIETRVQHQLRQGFPSQLTLNNCNIHAICLAANAGDPLATEIIRQAGHYLG 324
Cdd:cd24074   160 ELGHTQIDPYGKRCYCGNHGCLETVASIPAILEQANQLLEQSPDSMLHGQPISIESLCQAALAGDPLAQDIIIQVGRHLG 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 325 KAISITINLFNPQKVVIAGEIAEAKQVLLPAIQNCINKQVLKAFREELPVVVSELNHCSAIGAFALTKRAMLNGVLLQHL 404
Cdd:cd24074   240 RILAILVNLFNPEKILIGSPLNNAAEILFPALSQSIRQQSLPAYSQHLQIESTKFYNDGTMPGAALIKDALYDGSLLLKL 319


                  ...
gi 2189429128 405 LGG 407
Cdd:cd24074   320 LQG 322
ROK pfam00480
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ...
 90-393 1.11e-88

ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.


Pssm-ID: 395384 [Multi-domain]  Cd Length: 292  Bit Score: 270.37  E-value: 1.11e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128  90 IGIRLGRHDATLALFDMSGKTLTEERYailENTQQEVEKRIISAIESFIDQNQRRIRELIAISVIIPGLVDPDEGIIRYM 169
Cdd:pfam00480   1 IGIDIGGTKIAAALFDEEGEILARERV---PTPTTTTEETLVDAIAFFVDSAQRKFGELIAVGIGSPGLISPKYGYITNT 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 170 PHIKVDNWPLVYNLKNHFKTFCFIGHDIRSLALAENYFGATRDCEDSILVRIHRGTGAGVIVNNNILLNKRGNLGEIGHI 249
Cdd:pfam00480  78 PNIGWDNFDLVEKLEERFNVPVFFENDANAAALAEAVFGASKDVQNVIYVTVGTGVGGGVISNGKLFTGRNGVAGEIGHI 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 250 QIEPLGERCHCGNFGCLETIVSNSAIETRVQHQLRqgfpsqltlnNCNIHAICLAANAGDPLATEIIRQAGHYLGKAISI 329
Cdd:pfam00480 158 QLDPNGPKCGCGNHGCLETIASGRALEKRYQQKGE----------DLEGKDIIVLAEQGDEVAEEAVERLARYLAKAIAN 227

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2189429128 330 TINLFNPQKVVIAGEIAEAKQvLLPAIQNCINKQVLKAFRE--ELPVVVSELNHCSAIGAFALTKR 393
Cdd:pfam00480 228 LINLFDPQAIVLGGGVSNADG-LLEAIRSLVKKYLNGYLPVppVIIVAASLGDNAGALGAAALAKQ 292
NagC COG1940
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ...
 86-390 1.47e-84

Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];


Pssm-ID: 441543 [Multi-domain]  Cd Length: 306  Bit Score: 260.21  E-value: 1.47e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128  86 HFHTIGIRLGRHDATLALFDMSGKTLTEERYAI-LENTQQEVEKRIISAIESFIDQNQRRIRELIAISVIIPGLVDPDEG 164
Cdd:COG1940     4 AGYVIGIDIGGTKIKAALVDLDGEVLARERIPTpAGAGPEAVLEAIAELIEELLAEAGISRGRILGIGIGVPGPVDPETG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 165 IIRYMPHIK-VDNWPLVYNLKNHFKTFCFIGHDIRSLALAENYFGATRDCEDSILVRIHRGTGAGVIVNNNILLNKRGNL 243
Cdd:COG1940    84 VVLNAPNLPgWRGVPLAELLEERLGLPVFVENDANAAALAEAWFGAGRGADNVVYLTLGTGIGGGIVINGKLLRGANGNA 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 244 GEIGHIQIEPLGERCHCGNFGCLETIVSNSAIETRVQHQLRqgfpsqltLNNCNIHAICLAANAGDPLATEIIRQAGHYL 323
Cdd:COG1940   164 GEIGHMPVDPDGPLCGCGNRGCLETYASGPALLRRARELGG--------AEKLTAEELFAAARAGDPLALEVLDEAARYL 235

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2189429128 324 GKAISITINLFNPQKVVIAGEIAEAKQVLLPAIQNCINKQVLKAFREELPVVVSEL-NHCSAIGAFAL 390
Cdd:COG1940   236 GIGLANLINLLDPEVIVLGGGVSAAGDLLLEPIREALAKYALPPAREDPRIVPASLgDDAGLLGAAAL 303
ASKHA_ATPase_ROK_BsXylR-like cd24076
ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This ...
 88-390 5.53e-68

ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Bacillus subtilis xylose repressor (BsXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. BsXylR acts as transcriptional repressor of xylose-utilizing enzymes.


Pssm-ID: 466926 [Multi-domain]  Cd Length: 303  Bit Score: 217.43  E-value: 5.53e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128  88 HTIGIRLGRHDATLALFDMSGKTLTEERYAI-LENTQQEVEKRIISAIESFIDQNQRRIRELIAISVIIPGLVDPDEGII 166
Cdd:cd24076     2 AVIGVELGVDYITVVVTDLAGEVLWRREVPLpASDDPDEVLAQLAALIREALAAAPDSPLGILGIGVGVPGLVDSEDGVV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 167 RYMPHIKVDNWPLVYNLKNHFKTFCFIGHDIRSLALAENYFGATRDCEDSILVRIHRGTGAGVIVNNNILLNKRGNLGEI 246
Cdd:cd24076    82 LLAPNLGWRDVPLRDLLEEALGVPVFVDNEANAAALAEKRFGAGRGVSDLVYLSAGVGIGAGIILDGELYRGASGFAGEI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 247 GHIQIEPLGERCHCGNFGCLETIVSNSAIETRVQHQLRQGFPsqltlnnCNIHAICLAANAGDPLATEIIRQAGHYLGKA 326
Cdd:cd24076   162 GHMTVDPDGPPCSCGNRGCWETYASERALLRAAGRLGAGGEP-------LSLAELVEAARAGDPAALAALEEVGEYLGIG 234

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2189429128 327 ISITINLFNPQKVVIAGEIAEAKQVLLPAIQNCINKQVLKAFREELPVVVSELN-HCSAIGAFAL 390
Cdd:cd24076   235 LANLVNTFNPELVVLGGALAPLGPWLLPPLRAEVARRALPAPARDVRIVVSRLGeDAAALGAAAL 299
ASKHA_NBD_ROK_TM1224-like cd24059
nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and ...
 87-390 2.52e-63

nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to N-acetylglucosamine kinase (Tm1224; EC 2.7.1.59) from Thermotoga maritima, which belongs to kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Tm1224 lacks the cysteine-rich zinc-binding motif, which presents in other family members.


Pssm-ID: 466909 [Multi-domain]  Cd Length: 305  Bit Score: 205.51  E-value: 2.52e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128  87 FHTIGIRLGRHDATLALFDMSGKTLTEERYAI-LENTQQEVEKRIISAIESFIDQNQRRiRELIAISVIIPGLVDPDEGI 165
Cdd:cd24059     1 PYVIGVEIGRDLLSAVLCDLSGNILAREKYPLdEKENPEEVLEKLYELIDRLLEKENIK-SKILGIGIGAPGPLDVEKGI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 166 IRYMPHIK-VDNWPLVYNLKNHFKTFCFIGHDIRSLALAENYFGATRDCEDSILVRIHRGTGAGVIVNNNILLNKRGNLG 244
Cdd:cd24059    80 ILNPPNFPgWENIPLVELLEEKFGIPVYLDNDANAAALAEKWYGKGKNYDNFIYILADEGIGAGIIINGKLYRGVDGYAG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 245 EIGHIQIEPLGERCHCGNFGCLETIVSNSAIETRVQHQLRQGFPSQLtlnncnihAICLAANAGDPLATEIIRQAGHYLG 324
Cdd:cd24059   160 EIGHTSIDINGPRCSCGNRGCLELYASIPAIEKKARSALGSGRSFQL--------DIVEALQKGDPIADEVIEEAAKYLG 231

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2189429128 325 KAISITINLFNPQKVVIAGEIAEAKQVLLPAIQNCINKQVLKAFREELPVVVSEL-NHCSAIGAFAL 390
Cdd:cd24059   232 IGLVNLINLLNPEAIIIGGELIYLGERYLEPIEKEVNSRLFGRNAREVRILKSSLgEDAPLLGAAAL 298
ASKHA_ATPase_ROK_CYANR cd24073
ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; ...
 88-390 1.14e-61

ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; CYANR acts as transcriptional repressor of cyclobis-(1-6)-alpha-nigerosyl (CNN) degrading enzymes. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466923 [Multi-domain]  Cd Length: 304  Bit Score: 201.24  E-value: 1.14e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128  88 HTIGIRLGRHDATLALFDMSGKTLTEERYAILENTQQEVEKRIISAIESFIDQNQRRIRELIAISVIIPGLVDPDEGIIR 167
Cdd:cd24073     2 YVVGVKLTEDRITAVLTDLRGNVLASHTLPLDSGDPEAVAEAIAEAVAELLAQAGLSPDRLLGIGVGLPGLVDAETGICR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 168 YMPHIKVDNWPLVYNLKNHFKTFCFIGHDIRSLALAENYFGATRDCEDSILVRIHRGTGAGVIVNNNILLNKRGNLGEIG 247
Cdd:cd24073    82 WSPLLGWRDVPLAELLEERLGLPVYVENDVNALALAEHWFGAGRGLDNFAVVTIGRGIGCGLVVDGRLYRGAHGGAGEIG 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 248 HIQIEPLGERCHCGNFGCLETIVSNSAIETRVQHQLRQGFPsqltlnnCNIHAICLAANAGDPLATEIIRQAGHYLGKAI 327
Cdd:cd24073   162 HTTVDPDGPPCRCGKRGCLEAYASDPAILRQAREAGLRGEP-------LTIEDLLAAARAGDPAARAILRRAGRALGLAL 234

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2189429128 328 SITINLFNPQKVVIAGEIAEAKQVLLPAIQNCINKQVLKAFREELPVVVSELNHCS-AIGAFAL 390
Cdd:cd24073   235 ANLVNLLDPELIIISGEGVRAGDLLFEPMREALRAHVFPGLASDLELVIHPWGDEAwARGAAAL 298
ASKHA_ATPase_ROK_Lmo0178-like cd24071
ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily ...
 88-379 7.21e-57

ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Listeria monocytogenes Lmo0178 protein, which is a predicted transcription repressor belonging to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466921 [Multi-domain]  Cd Length: 312  Bit Score: 189.03  E-value: 7.21e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128  88 HTIGIRLGRHDATLALFDMSGKTLTEERYAILENTQQE-VEKRIISAIESFIDQNQRRIReLIAISVIIPGLVDPDEGII 166
Cdd:cd24071     2 YIIGVKIEEGYLVLALTDLKGKILEKTRIPFDHETDPEkVIELIAENIKKLIKNKHVEKK-LLGIGIAVSGLVDSKKGIV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 167 RYMPHIKVDNWPLVYNLKNHFKTFCFIGHDIRSLALAENYFGATRDCEDSILVRIHRGTGAGVIVNNNILLNKRGNLGEI 246
Cdd:cd24071    81 IRSTILGWENVELKKILKEKFKIPVFIDNDVNSFALAELWKGKGKGYSNFICVTVGAGIGSSLVIDGKLYTGNFGGAGEI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 247 GHIQIEPLGERCHCGNFGCLETIVSNSAIETRVQHQLRQGFPSQLT-LNNCNIHAICLAANAGDPLATEIIRQAGHYLGK 325
Cdd:cd24071   161 GHMTIQPDGRKCYCGQKGCLEAYASFEALVNEIKELTESYPLSLLKeLEDFEIEKVREAAEEGDSVATELFKKAGEYLGI 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2189429128 326 AISITINLFNPQKVVIAGEIAEAKQVLLPAIQNCINKQVLKAFREELPVVVSEL 379
Cdd:cd24071   241 GIKNLINIFNPEAIIIGGEGLEFKDYFLPKIIEIAKENFFGKAGRNVIILVDSL 294
ASKHA_ATPase_ROK cd23763
ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family ...
 90-390 2.73e-47

ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family corresponds to a group of proteins including sugar kinases, transcriptional repressors, and yet uncharacterized open reading frames. ROK family sugar kinases phosphorylate a range of structurally distinct hexoses including the key carbon source D-glucose, various glucose epimers, and several acetylated hexosamines. The sugar kinases include N-acetyl-D-glucosamine kinase (NAGK; EC 2.7.1.59), polyphosphate glucokinase (PPGK; EC 2.7.1.63/EC 2.7.1.2), glucokinase (GLK; EC 2.7.1.2), fructokinase (FRK; EC 2.7.1.4), hexokinase (HK; EC 2.7.1.1), D-allose kinase (AlsK; EC 2.7.1.55), bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE; EC 3.2.1.183/EC 2.7.1.60), N-acetylmannosamine kinase (NanK; EC 2.7.1.60), beta-glucoside kinase (BglK; EC 2.7.1.85), and N-acetylglucosamine kinase (EC 2.7.1.59). The family also contains the repressor proteins, such as N-acetylglucosamine repressor (NagC), xylose repressor (XylR), cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and protein Mlc. ROK kinases harbor a conserved N-terminal ATP binding motif of sequence DxGxT, while ROK repressors possess a N-terminal extension that contains a canonical helix-turn-helix DNA binding motif. The ROK family proteins belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466849 [Multi-domain]  Cd Length: 239  Bit Score: 161.48  E-value: 2.73e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128  90 IGIRLGRHDATLALFDMSGKTLTEERYAI-LENTQQEVEKRIISAIESFIDQNQRRiRELIAISVIIPGLVDPDEGIIRY 168
Cdd:cd23763     1 IGIDIGGTKIRAALVDLDGEILARERVPTpAEEGPEAVLDRIAELIEELLAEAGVR-ERILGIGIGVPGPVDPETGIVLF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 169 MPHIK-VDNWPLVYNLKNHFKTFCFIGHDIRSLALAENYFGATRDCEDSILVRIHRGTGAGVIVNNNILLNKRGNLGEIG 247
Cdd:cd23763    80 APNLPwWKNVPLRELLEERLGLPVVVENDANAAALGEAWFGAGRGVRNFVYITLGTGIGGGIIIDGKLYRGANGAAGEIG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 248 HIQieplgerchcgnfgcletivsnsaietrvqhqlrqgfpsqltlnncnihaiclaanagdplateIIRQAGHYLGKAI 327
Cdd:cd23763   160 HIT----------------------------------------------------------------VLEEAARYLGIGL 175

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2189429128 328 SITINLFNPQKVVIAGEIAEAKQVLLPAIQNCINKQVLKAFREELPVVVSEL-NHCSAIGAFAL 390
Cdd:cd23763   176 ANLINLLNPELIVLGGGVAEAGDLLLEPIREAVRRRALPPLRRRVRIVPSELgDDAGLLGAAAL 239
ASKHA_ATPase_ROK_YphH-like cd24072
ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily ...
 88-379 1.48e-45

ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Escherichia coli protein YphH that belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466922 [Multi-domain]  Cd Length: 308  Bit Score: 159.12  E-value: 1.48e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128  88 HTIGIRLGRHDATLALFDMSGKTLTEERYAILEntqQEVEKRIISAIESFID-QNQRRIRELIAISVIIPGLVDPDEGII 166
Cdd:cd24072     2 WVLGIVVSPNSLRAQVGNACGELLGEFEYRVIT---LETPEALIDEIIDCIDrLLKLWKDRVKGIALAIQGLVDSHKGVS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 167 RYMPHIKVDNWPLVYNLKNHFKTFCFIGHDIRSLALAENYFGATRDCEDSILVRIHRGTGAGVIVNNNILLNKRGNLGEI 246
Cdd:cd24072    79 LWSPGAPWRNIEIKYLLEERYGIPVFVENDCNMLALAEKWQGELRQSRDFCVINLDYGIGSAIVIDNKLYIGASSGSGEI 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 247 GHIQIEPLGERCHCGNFGCLETIVSNSAIEtRVQHQLRQGFPSQLTLNNCNIHAICLAANAGDPLATEIIRQAGHYLGKA 326
Cdd:cd24072   159 GHTKVNPDGARCDCGRRGCLETVASNSALK-RNARVTLKLGPVSADPEKLTMEQLIEALEEGEPIATQIFDRAANAIGRS 237

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2189429128 327 ISITINLFNPQKVVIAGEIAEAKQVLLPAIqncinkqvLKAFREELPVVVSEL 379
Cdd:cd24072   238 LANILNLLNPEQVLLYGRGCRAGDLLLPAI--------RRAIAENPFSQHATQ 282
ASKHA_NBD_ROK_FnNanK-like cd24068
nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and ...
 102-390 2.42e-45

nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and similar proteins; The family includes Fusobacterium nucleatum N-acetylmannosamine kinase (NanK; EC 2.7.1.60) and beta-glucoside kinase (BglK; EC 2.7.1.85) from Klebsiella pneumoniae and Listeria innocua. NanK catalyzes the second step of the sialic acid catabolic pathway, transferring a phosphate group from adenosine 5'-triphosphate to the C6 position of N-acetylmannosamine to generate N-acetylmannosamine 6-phosphate. Unlike other NanK enzymes and ROK family members, F. nucleatum NanK does not have a conserved zinc-binding site. BglK catalyzes the ATP-dependent phosphorylation of cellobiose to produce cellobiose-6'-P. It may have a dual role of kinase and transcriptional regulator of the cellobiose-PTS operon. The subfamily belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466918 [Multi-domain]  Cd Length: 294  Bit Score: 158.10  E-value: 2.42e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 102 ALFDMSGKTLTEERYAIL-ENTQQEVEKRIISAIESFIDQNQRrirELIAISviIPGLVDPDEGIIRYM-PHIKvdNW-- 177
Cdd:cd24068    15 GLVDADGEILEKDSVPTPaSKGGDAILERLLEIIAELKEKYDI---EGIGIS--SAGQVDPKTGEVIYAtDNLP--GWtg 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 178 -PLVYNLKNHFKTFCFIGHDIRSLALAENYFGATRDCEDSILVRIHRGTGAGVIVNNNILLNKRGNLGEIGHIQIEPLGE 256
Cdd:cd24068    88 tNLKEELEERFGLPVAVENDVNCAALAEKWLGAAKGLDDFLCLTLGTGIGGAIILDGRLYRGANGSAGELGHMVVDPGGR 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 257 RCHCGNFGCLETIVSNSAIETRVQHQLRQgfpsqltlNNCNIHAICLAANAGDPLATEIIRQAGHYLGKAISITINLFNP 336
Cdd:cd24068   168 PCCCGGKGCLEQYASGTALVRRVAEALGE--------PGIDGREIFDLADAGDPLAKEVVEEFAEDLATGLANLVHIFDP 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2189429128 337 QKVVIAGEIAEAKQVLLPAIQNCINKQVLKAFREELPVVVSEL-NHCSAIGAFAL 390
Cdd:cd24068   240 EVIVIGGGISAQGELFLEELREELRKLLMPPLLDATKIEPAKLgNDAGLLGAAYL 294
ASKHA_NBD_ROK_TmGLK-like cd24064
nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; ...
 90-379 1.55e-43

nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466914 [Multi-domain]  Cd Length: 301  Bit Score: 153.81  E-value: 1.55e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128  90 IGIRLGRHDATLALFDMSGKTLTEE-RYAILENTQQEVEKRIISAIESFIDQNqrrirELIAISVIIPGLVDPDEGIIRY 168
Cdd:cd24064     2 IGIDLGGTDTKIGIVDENGDILKKKtIDTKVENGKEDVINRIAETVNELIEEM-----ELLGIGIGSPGSIDRENGIVRF 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 169 MPHIKvdNW---PLVYNLKNHFKTFCFIGHDIRSLALAENYFGATRDCEDSILVRIHRGTGAGVIVNNNILLNKRGNLGE 245
Cdd:cd24064    77 SPNFP--DWrnfPLVPLIEERTGIKVFLENDANAFALGEWWFGNAKGSNHIIGLTLGTGVGSGVICHGQLLTGYDGIAAE 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 246 IGHIQIEPLGERCHCGNFGCLETIVSNSAIeTRVQHQLRQGFPSQLTLNNCNIHA--ICLAANAGDPLATEIIRQAGHYL 323
Cdd:cd24064   155 LGHVIVEPNGPICGCGNRGCVEAFASATAI-IRYARESRKRYPDSLAGESEKINAkhVFDAARKNDPLATMVFRRVVDAL 233

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2189429128 324 GKAISITINLFNPQKVVIAGEIAEAKQVLLPAIQNCINKQVLKAFREELPVVVSEL 379
Cdd:cd24064   234 AIAIGGFVHIFNPEIIIIGGGISRAGSFLLDPIREKTKKYVMLSFQDTYSIELSNL 289
ASKHA_ATPase_ROK_SaXylR-like cd24077
ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This ...
 88-390 6.51e-43

ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Staphylococcus aureus xylose repressor (SaXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. SaXylR acts as a transcriptional repressor of xylose-utilizing enzymes. It lacks the cysteine-rich zinc-binding motif, which presents in other family members.


Pssm-ID: 466927 [Multi-domain]  Cd Length: 295  Bit Score: 151.92  E-value: 6.51e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128  88 HTIGIRLGRHDATLALFDMSGKTLTEERYAILENTQQEVEKRIISAIESFIDQNQRRIRELIAISVIIPGLVDPDEgiIR 167
Cdd:cd24077     2 YSIGIDLGYNYISLMLTYLDGEIISSKQIKLLDISFENILEILKSIIQELISQAPKTPYGLVGIGIGIHGIVDENE--II 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 168 YMPHIKVDNWPLVYNLKNHFKTFCFIGHDIRSLALAENYFgaTRDCEDSILVRIHRGTGAGVIVNNNILLNKRGNLGEIG 247
Cdd:cd24077    80 FTPYYDLEDIDLKEKLEEKFNVPVYLENEANLSALAERTF--SEDYDNLISISIHSGIGAGIIINNQLYRGYNGFAGEIG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 248 HIQIEPLGERCHCGNFGCLETIVSNSAIETRVQHQLRqgfpsqltLNNCNIHAICLAANAGDPLATEIIRQAGHYLGKAI 327
Cdd:cd24077   158 HMIIVPNGKPCPCGNKGCLEQYASEKALLKELSEKKG--------LETLTFDDLIQLYNEGDPEALELIDQFIKYLAIGI 229

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2189429128 328 SITINLFNPQKVVIAGEIAEAkqvlLPAIQNCINKQVLKAFREELPVVVSEL-NHCSAIGAFAL 390
Cdd:cd24077   230 NNIINTFNPEIIIINSSLINE----IPELLEKIKEQLSSSFNKYVEILISTLgKNATLLGGAAV 289
ASKHA_NBD_ROK_SgGLK-like cd24061
nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; ...
 89-387 2.65e-39

nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466911 [Multi-domain]  Cd Length: 306  Bit Score: 142.49  E-value: 2.65e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128  89 TIGIRLGRHDATLALFDMSGKTLTEERYAilenTQQEVEKrIISAIESFIDQNQRRiRELIAISVIIPGLVDPDEGIIRY 168
Cdd:cd24061     1 TIGVDIGGTKIAAGVVDEEGEILATERVP----TPPTADG-IVDAIVEAVEELREG-HDVSAVGVAAAGFVDADRATVLF 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 169 MPHIKVDNWPLVYNLKNHFKTFCFIGHDIRSLALAENYFGATRDCEDSILVRIHRGTGAGVIVNNNILLNKRGNLGEIGH 248
Cdd:cd24061    75 APNIAWRNEPLKDLLEARIGLPVVIENDANAAAWAEYRFGAGRGTDDMVMITVGTGLGGGIVIGGKLLRGAFGIAGEFGH 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 249 IQIEPLGERCHCGNFGCLETIVSNSAIETRVQHQL-RQGFPSQLTLNNCNI-----HAICLAANAGDPLATEIIRQAGHY 322
Cdd:cd24061   155 IRVVPDGLLCGCGSRGCWEQYASGRALVRYAKEAAnATPEGAAVLLADGSVdgitgKHISEAARAGDPVALDALRELARW 234

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2189429128 323 LGKAISITINLFNPQKVVIAGEIAEAKQVLLPAIQncinkqvlKAFREELP---------VVVSEL-NHCSAIGA 387
Cdd:cd24061   235 LGAGLASLAALLDPELFVIGGGVSDAGDLLLDPIR--------EAFERWLPgrgwrpiprLRTAQLgNDAGLIGA 301
ASKHA_NBD_ROK_ApGLK-like cd24063
nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; ...
 90-390 9.37e-38

nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466913 [Multi-domain]  Cd Length: 308  Bit Score: 138.63  E-value: 9.37e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128  90 IGIRLGRHDATLALFDMSGKTLTEERYAILENTQQ-EVEKRIISAIESFIDQNQRRIRELIAISVIIPglVDPDEGIIRY 168
Cdd:cd24063     3 VAVDIGGTWIRAGLVDEDGRILLKIRQPTPKTGDPgTVSEQVLGLIETLLSKAGKDSIEGIGVSSAGP--LDLRKGTIVN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 169 MPHIKVDNWPLVYNLKNHFKTFCFIGHDIRSLALAENYFGATRDCEDSILVRIHRGTGAGVIVNNNILLNKRGNLGEIGH 248
Cdd:cd24063    81 SPNIKGKEIPLVEPLKEEFNIPVALLNDAVAAALGEHLFGAGRGTSNLVYITISTGIGGGVIVDGRLLLGKNGNAAEVGH 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 249 IQIEP-LGERCHCGNFGCLETIVSNSAIeTRVQHQLRQGFPSQLTLNNCNI-------HAICLAANAGDPLATEIIRQAG 320
Cdd:cd24063   161 LVVDTeSGLKCGCGGYGHWEAFASGRGI-PRFAREWAEGFSSRTSLKLRNPggegitaKEVFSAARKGDPLALKIIEKLA 239

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2189429128 321 HYLGKAISITINLFNPQKVVIAGEIAEAKQVLL-PAIqncinKQVLKAFREELP--VVVSEL-NHCSAIGAFAL 390
Cdd:cd24063   240 RYNGRGIANVINAYDPELIVIGGSVFNNNKDILdPLI-----EYLEKNPAISKGpeIVLSELgDDVGLIGALAL 308
ASKHA_NBD_ROK_BsGLK-like cd24062
nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; ...
 90-387 2.53e-37

nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466912 [Multi-domain]  Cd Length: 311  Bit Score: 137.42  E-value: 2.53e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128  90 IGIRLGRHDATLALFDMSGKTLteERYAILENTQqEVEKRIISAIESFIDQnqrRIREL-------IAISVIIPGLVDPD 162
Cdd:cd24062     3 VGIDVGGTTIKMAFLTQEGEIV--QKWEIPTNKL-EGGENIITDIAESIQQ---LLEELgyskedlIGIGVGVPGPVDVE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 163 EGIIRYMPHIKVDNWPLVYNLKNHFKTFCFIGHDIRSLALAENYFGATRDCEDSILVRIHRGTGAGVIVNNNILLNKRGN 242
Cdd:cd24062    77 TGTVEVAVNLGWKNFPLKDKLEALTGIPVVIDNDANAAALGEMWKGAGQGAKDLVFITLGTGVGGGVIANGKIVHGANGA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 243 LGEIGHIQIEP-LGERCHCGNFGCLETIVSNSAIeTRVQHQLRQGFPSQLTLNNCNIHA------ICLAANAGDPLATEI 315
Cdd:cd24062   157 AGEIGHITVNPeGGAPCNCGKTGCLETVASATGI-VRIAREELEEGKGSSALRILALGGeltakdVFEAAKAGDELALAV 235

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2189429128 316 IRQAGHYLGKAISITINLFNPQKVVIAGEIAEAKQVLLPAIQNCINKQVLKAFREELPVVVSEL-NHCSAIGA 387
Cdd:cd24062   236 VDTVARYLGLALANLANTLNPEKIVIGGGVSAAGEFLLSPVKEYFDRFTFPRVRQDTEIVLATLgNDAGVIGA 308
ASKHA_NBD_ROK_TtHK-like cd24065
nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; ...
 89-357 2.90e-35

nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; HK (EC 2.7.1.1) possesses the ability to transfer an inorganic phosphate group from ATP to a substrate. It catalyzes the ATP-dependent phosphorylation of aldo- and keto-hexose sugars to the hexose-6-phosphate (H6P). Thermus thermophilus HK possesses significant enzymatic activity against glucose and mannose. However, it shows little catalytic capacity for galactose and fructose. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466915 [Multi-domain]  Cd Length: 289  Bit Score: 131.30  E-value: 2.90e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128  89 TIGIRLGRHDATLALFDmSGKTLTEERYAilenTQQEVEKRIISAIESFIDQNQRRIRELIAISVIIPGLVDPDEGIIRY 168
Cdd:cd24065     2 TIGLDLGGTKIAAGVVD-GGRILSRLVVP----TPREGGEAVLDALARAVEALQAEAPGVEAVGLGVPGPLDFRRGRVRF 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 169 MPHIK-VDNWPLVYNLKNHFKTFCFIGHDIRSLALAENYFGATRDCEDSILVRIHRGTGAGVIVNNNILLNKRGNLGEIG 247
Cdd:cd24065    77 APNIPgLTDFPIRRGLAERLGLPVVLENDANAAALAEHHYGAARGTESSVYVTISTGIGGGLVLGGRVLRGRHGQAGEIG 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 248 HIQIEPLGERCHCGNFGCLETIVSNSAIETRVQHQLRQGFPSqltlnncniHAICLAANAGDPLATEIIRQAGHYLGKAI 327
Cdd:cd24065   157 HTTVLPGGPMCGCGLVGCLEALASGRALARDASFAYGRPMST---------AELFELAQQGEPKALRIVEQAAAHLGIGL 227

                         250       260       270
                  ....*....|....*....|....*....|
gi 2189429128 328 SITINLFNPQKVVIAGEIAEAKQVLLPAIQ 357
Cdd:cd24065   228 ANLQKALDPEVFVLGGGVAQVGDYYLLPVQ 257
PRK09698 PRK09698
D-allose kinase; Provisional
 90-397 1.14e-23

D-allose kinase; Provisional


Pssm-ID: 182034 [Multi-domain]  Cd Length: 302  Bit Score: 100.06  E-value: 1.14e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128  90 IGIRLGRHDATLALFDMSGKTLTEERYAILENTQQEVEKRIISAIESFIDQNQRRIReliAISVIIPGLVDPDEGIIRYM 169
Cdd:PRK09698    7 LGIDMGGTHIRFCLVDAEGEILHCEKKRTAEVIAPDLVSGLGEMIDEYLRRFNARCH---GIVMGFPALVSKDRRTVIST 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 170 PHIKV---DNWPLVYNLKNHFKTFCFIGHDIRSLALaenYFGATRDCEDSILVRIHRGTGAG--VIVNNNILLNKRGNLG 244
Cdd:PRK09698   84 PNLPLtalDLYDLADKLENTLNCPVFFSRDVNLQLL---WDVKENNLTQQLVLGAYLGTGMGfaVWMNGAPWTGAHGVAG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 245 EIGHIQIEPLGERCHCGNFGCLETIVSNSAIETRVQHQLRQGFPSQLTLnncnihaiclaaNAGDplaTEIIRQAGHYLG 324
Cdd:PRK09698  161 ELGHIPLGDMTQHCGCGNPGCLETNCSGMALRRWYEQQPRDYPLSDLFV------------HAGD---HPFIQSLLENLA 225

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2189429128 325 KAISITINLFNPQKVVIAGEIAEAKQVLLPAIQNCINKQVLKAF-REELPVVVSELN-HCSAIGAFALTKRAMLN 397
Cdd:PRK09698  226 RAIATSINLFDPDAIILGGGVMDMPAFPRETLIAMIQKYLRKPLpYEVVRFIYASSSdFNGAQGAAILAHQRFLP 300
ASKHA_NBD_ROK_AlsK cd24070
nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1. ...
 129-350 7.28e-23

nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1.55), also called allokinase, catalyzes the phosphorylation of D-allose to D-allose 6-phosphate. It has also low level glucokinase activity in vitro. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466920 [Multi-domain]  Cd Length: 293  Bit Score: 97.62  E-value: 7.28e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 129 RIISAIESFIDQNQRRIReliAISVIIPGLVDPDEGIIRYMPHIKV-DNWPLVYNLKNHFKTFCFIGHDIRSLALAENYF 207
Cdd:cd24070    44 VLADLIREYIEEAGLKPA---AIVIGVPGTVDKDRRTVISTPNIPGlDGVNLADILENKLGIPVILERDVNLLLLYDMRA 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 208 GATRDceDSILVRIHRGTGAG--VIVNNNILLNKRGNLGEIGHIQIEPLGERCHCGNFGCLETIVSNSAIETRVQHqlrq 285
Cdd:cd24070   121 GNLDD--EGVVLGFYIGTGIGnaILINGKPLRGKNGVAGELGHIPVYGNGKPCGCGNTGCLETYASGRALEEIAEE---- 194

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2189429128 286 gfpsqltlNNCNIHAICLAANAGDplaTEIIRQAGHYLGKAISITINLFNPQKVVIAGEIAEAKQ 350
Cdd:cd24070   195 --------HYPDTPILDIFVDHGD---EPELDEFVEDLALAIATEINILDPDAVILGGGVIDMKG 248
ASKHA_NBD_ROK_GNE cd24060
nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase ...
 157-390 1.46e-20

nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) and similar proteins; GNE (EC 3.2.1.183/EC 2.7.1.60), also called UDP-GlcNAc-2-epimerase/ManAc kinase, is a bi-functional enzyme that plays a key role in sialic acid biosynthesis. It regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It plays an essential role in early development and required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. GNE is the only human protein that contains a kinase domain belonging to the ROK (repressor, ORF, kinase) family. Mutations of the GNE protein cause sialurea or autosomal recessive inclusion body myopathy/Nonaka myopathy.


Pssm-ID: 466910 [Multi-domain]  Cd Length: 305  Bit Score: 91.32  E-value: 1.46e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 157 GLVDPDEGIIRYMPHIkVDNW---PLVYNLKNHFKTFCFIGHDIRSLALAENYFGATRDCEDSILVRIHRGTGAGVIVNN 233
Cdd:cd24060    69 GRVNPREGIVLHSTKL-IQEWssvDLRTPISDALHLPVWVDNDGNCAALAERKFGHGKGVENFVTVITGTGIGGGIILNH 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 234 NILLNKRGNLGEIGHIQIEPLGERCHCGNFGCLETIVSNSAIETRVQHQLRQG---FPSQLTLNNCNIHAICL--AANAG 308
Cdd:cd24060   148 ELIHGSSFCAAELGHIVVSLDGPDCMCGSHGCVEAYASGMALQREAKKLHDEDlllVEGMSVTNDEEVTAKHLiqAAKLG 227

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 309 DPLATEIIRQAGHYLGKAISITINLFNPQKVVIAGEIAEakqVLLPAIQNCINKQVLKAFReELPVVVSELNHCSAIGAF 388
Cdd:cd24060   228 NAKAQKILRTAGTALGLGIVNILHTLNPSLVILSGVLAS---HYENIVKDVIAQRALPSVQ-NVDVVVSDLVDPALLGAA 303


                  ..
gi 2189429128 389 AL 390
Cdd:cd24060   304 SM 305
ASKHA_NBD_ROK_EcNanK-like cd24069
nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar ...
 126-356 3.18e-17

nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar proteins; N-acetylmannosamine kinase (NanK; EC 2.7.1.60), also called ManNAc kinase, or N-acetyl-D-mannosamine kinase, catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P. It has also low level glucokinase activity in vitro. This subfamily also contains Brucella melitensis bifunctional enzyme NanE/NanK (EC 5.1.3.9/EC 2.7.1.60), which also converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466919 [Multi-domain]  Cd Length: 283  Bit Score: 81.18  E-value: 3.18e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 126 VEKRIISAIESFIDQNQRR-IRELIA--------ISVIIPGLVDpdEGIIRYMPHIKVDNW---PLVYNLKNHFKTFCFI 193
Cdd:cd24069    21 IDRRQIPTPRSGTPEALADaLASLLAdyqgqfdrVAVASTGIIR--DGVLTALNPKNLGGLsgfPLADALQQLLGVPVVL 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 194 GHDIRSLALAENYFGATRDCEDSILVRIHRGTGAGVIVNNNILLNKRGNLGEIGHIQIEPLGERCHCGNFGCLETIVSNS 273
Cdd:cd24069    99 LNDAQAAAWGEYQAGDGEGVGNLVFITVSTGVGGGLVLNGQLLTGPNGLAGHIGHTLADPPGPVCGCGRRGCVEAIASGT 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 274 AIETRVQHQLRQGFPSQltlnncnihAICLAANAGDPLATEIIRQAGHYLGKAISITINLFNPQKVVIAG---------E 344
Cdd:cd24069   179 AIAAAASEILGEPVDAK---------DVFERARSGDEEAARLIDRAARALADLIADLKATLDLDCVVIGGsvglaegflE 249

                         250
                  ....*....|..
gi 2189429128 345 IAEAKQVLLPAI 356
Cdd:cd24069   250 RVEQYLADEPAI 261
ASKHA_NBD_ROK_EcFRK-like cd24066
nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; ...
 90-343 1.00e-16

nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; Escherichia coli FRK (EC 2.7.1.4), also called D-fructose kinase, manno(fructo)kinase, or MAK, catalyzes the phosphorylation of fructose to fructose-6-phosphate. It has also low level glucokinase activity in vitro. It is not able to phosphorylate D-ribose, D-mannitol, D-sorbitol, inositol, and L-threonine. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466916 [Multi-domain]  Cd Length: 294  Bit Score: 79.94  E-value: 1.00e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128  90 IGIRLGRHDATLALFDMSGKTLTEERyailENTQQEVEKRIISAIESFIDQNQRRIRELIAISVIIPGLVDPDEGIIrym 169
Cdd:cd24066     2 IGIDLGGTKIEGIALDRAGRELLRRR----VPTPRGDYEATLDAIADLVEEAEEELGAPATVGIGTPGSISPRTGLV--- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 170 phiKVDN--W----PLVYNLKNHFKTFCFIGHDIRSLALAENYFGATRDCEDSILVRIHRGTGAGVIVNNNILLNKRGNL 243
Cdd:cd24066    75 ---KNANstWlngkPLKADLEARLGRPVRIENDANCFALSEATDGAGAGAGVVFGVILGTGVGGGIVVNGRVLTGANGIA 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 244 GEIGHIQIEPL------GERCHCGNFGCLETIVSNSAIETrvQHQLRQGfpSQLTLnncniHAICLAANAGDPLATEIIR 317
Cdd:cd24066   152 GEWGHNPLPWPdedelpGPPCYCGKRGCVETFLSGPALER--DYARLTG--KTLSA-----EEIVALARAGDAAAVATLD 222

                         250       260
                  ....*....|....*....|....*.
gi 2189429128 318 QAGHYLGKAISITINLFNPQKVVIAG 343
Cdd:cd24066   223 RFLDRLGRALANVINILDPDVIVLGG 248
ASKHA_NBD_ROK-like cd24152
nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This ...
 102-362 1.60e-16

nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This subfamily is composed of uncharacterized proteins belonging to the the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466988 [Multi-domain]  Cd Length: 286  Bit Score: 79.15  E-value: 1.60e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 102 ALFDMSGKTLTEERyailENTQQEVEKRIISAIESFIDQNQRRIrELIAISviIPGLVDPDEGII------RYMphikvD 175
Cdd:cd24152    15 ALVDENGNIIKKGK----IPTPKDSLEEFLDYIKKIIKRYDEEI-DGIAIS--APGVIDPETGIIygggalPYL-----K 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 176 NWPLVYNLKNHFKTFCFIGHDIRSLALAENYFGATRDCEDSILVRIHRGTGAGVIVNNNILLNKRGNLGEIGHIQIEPLG 255
Cdd:cd24152    83 GFNLKEELEERCNLPVSIENDAKCAALAELWLGSLKGIKNGAVIVLGTGIGGAIIIDGKLYRGSHFFAGEFSYLLTDDDD 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 256 ERCHCGNFGCletivSNSAIETRVQHQLRqgfpsqltLNNCNIHAICLAANAGDPLATEIIRQAGHYLGKAIsITIN-LF 334
Cdd:cd24152   163 KDLLFFSGLA-----SMFGLVKRYNKAKG--------LEPLDGEEIFEKYAKGDEAAKKILDEYIRNLAKLI-YNIQyIL 228

                         250       260
                  ....*....|....*....|....*...
gi 2189429128 335 NPQKVVIAGEIAEAkQVLLPAIQNCINK 362
Cdd:cd24152   229 DPEVIVIGGGISEQ-PLFIEDLKKEVNE 255
ASKHA_NBD_ROK_NAGK cd24057
nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; ...
 101-343 1.08e-13

nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; NAGK (EC 2.7.1.59), also called GlcNAc kinase, catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466907 [Multi-domain]  Cd Length: 298  Bit Score: 71.11  E-value: 1.08e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 101 LALFDMSGKTLTEERYAilenTQQEVEKRIISAIESFIDQNQRRIRELIAISVIIPGLVDPDEGIIRY--MPHIKvdNWP 178
Cdd:cd24057    14 FAVFDEALQLVWTKRVP----TPTDDYAAFLAAIAELVAEADARFGVKGPVGIGIPGVIDPEDGTLITanIPAAK--GRP 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 179 LVYNLKNHFKTFCFIGHDIRSLALAENYFGATRDcEDSILVRI-HRGTGAGVIVNNNILLNKRGNLGEIGH----IQIEP 253
Cdd:cd24057    88 LRADLSARLGRPVRIDNDANCFALSEAWDGAGRG-YPSVFGLIlGTGVGGGLVVNGRLVGGRSGIAGEWGHgplpADALL 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 254 LGE-----RCHCGNFGCLETIVSNSAIETRVQHQLRQGFPSQltlnncnihAICLAANAGDPLATEIIRQAGHYLGKAIS 328
Cdd:cd24057   167 LGYdlpvlRCGCGQTGCLETYLSGRGLERLYAHLYGEELDAP---------EIIAAWAAGDPQAVAHVDRWLDLLAGCLA 237

                         250
                  ....*....|....*
gi 2189429128 329 ITINLFNPQKVVIAG 343
Cdd:cd24057   238 NILTALDPDVVVLGG 252
PRK05082 PRK05082
N-acetylmannosamine kinase; Provisional
 178-345 2.17e-12

N-acetylmannosamine kinase; Provisional


Pssm-ID: 235338 [Multi-domain]  Cd Length: 291  Bit Score: 67.25  E-value: 2.17e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 178 PLVYNLKNHFKTFCFIGHDIRSLALAEnYFGATRDCEDSILVRIHRGTGAGVIVNNNILLNKRGNLGEIGHIQIEPLGER 257
Cdd:PRK05082   87 PLVQTLEQLTDLPTIALNDAQAAAWAE-YQALPDDIRNMVFITVSTGVGGGIVLNGKLLTGPGGLAGHIGHTLADPHGPV 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 258 CHCGNFGCLETIVSNSAIETRvqhqlrqgfpSQLTLNNCNIHAICLAANAGDPLATEIIRQAGHYLGKAI-SITINLfNP 336
Cdd:PRK05082  166 CGCGRRGCVEAIASGRAIAAA----------AQGWLAGCDAKTIFERAGQGDEQAQALINRSAQAIARLIaDLKATL-DC 234


                  ....*....
gi 2189429128 337 QKVVIAGEI 345
Cdd:PRK05082  235 QCVVLGGSV 243
PRK09557 PRK09557
fructokinase; Reviewed
 90-375 1.22e-10

fructokinase; Reviewed


Pssm-ID: 236565 [Multi-domain]  Cd Length: 301  Bit Score: 61.97  E-value: 1.22e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128  90 IGIRLGRHDATLALFDMSGKTLTEERYaileNTQQEVEKRIISAIESFIDQNQRRIRELIAISVIIPGLVDPDEGIIRYM 169
Cdd:PRK09557    3 IGIDLGGTKIEVIALDDAGEELFRKRL----PTPRDDYQQTIEAIATLVDMAEQATGQRGTVGVGIPGSISPYTGLVKNA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 170 PHIKVDNWPLVYNLKNHFKTFCFIGHDIRSLALAENYFGATRDCEDSILVRIHRGTGAGVIVNNNILLNKRGNLGEIGHi 249
Cdd:PRK09557   79 NSTWLNGQPLDKDLSARLNREVRLANDANCLAVSEAVDGAAAGKQTVFAVIIGTGCGAGVAINGRVHIGGNGIAGEWGH- 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 250 qiEPL------------GERCHCGNFGCLETIVSNSAIETrvQHQLRQGFPsqltLNNCNIHAIclaANAGDPLATEIIR 317
Cdd:PRK09557  158 --NPLpwmdedelryrnEVPCYCGKQGCIETFISGTGFAT--DYRRLSGKA----LKGSEIIRL---VEEGDPVAELAFR 226

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2189429128 318 QAGHYLGKAISITINLFNPQKVVIAGEIA--EAKQVLLPAIqncINKQVLKafRE-ELPVV 375
Cdd:PRK09557  227 RYEDRLAKSLAHVINILDPDVIVLGGGMSnvDRLYPTLPAL---LKQYVFG--GEcETPVR 282
PRK13310 PRK13310
N-acetyl-D-glucosamine kinase; Provisional
 101-343 5.07e-09

N-acetyl-D-glucosamine kinase; Provisional


Pssm-ID: 183967 [Multi-domain]  Cd Length: 303  Bit Score: 56.92  E-value: 5.07e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 101 LALFDMSGKTLTEERYAilenTQQEVEKRIISAIESFIDQNQRRIRELIAISVIIPGLVDPDEGIIrYMPHIKV-DNWPL 179
Cdd:PRK13310   14 LGVFNEKLELQWEERVP----TPRDSYDAFLDAVCELVAEADQRFGCKGSVGIGIPGMPETEDGTL-YAANVPAaSGKPL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 180 VYNLKNHFKTFCFIGHDIRSLALAENYFGATRDcEDSILVRI-HRGTGAGVIVNNNILLNKRGNLGEIGHIQI-----EP 253
Cdd:PRK13310   89 RADLSARLGRDVRLDNDANCFALSEAWDDEFTQ-YPLVMGLIlGTGVGGGLVFNGKPISGRSYITGEFGHMRLpvdalTL 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 254 LGE-----RCHCGNFGCLETIVSNSAIETRVQHQLRQGFPSQltlnncnihAICLAANAGDPLATEIIRQAGHYLgkAIS 328
Cdd:PRK13310  168 LGWdaplrRCGCGQKGCIENYLSGRGFEWLYQHYYGEPLQAP---------EIIALYYQGDEQAVAHVERYLDLL--AIC 236

                         250
                  ....*....|....*..
gi 2189429128 329 IT--INLFNPQKVVIAG 343
Cdd:PRK13310  237 LGniLTIVDPHLVVLGG 253
ASKHA_NBD_ROK_BsFRK-like cd24067
nucleotide-binding domain (NBD) of Bacillus subtilis fructokinase (FRK) and similar proteins; ...
 131-390 1.82e-07

nucleotide-binding domain (NBD) of Bacillus subtilis fructokinase (FRK) and similar proteins; Bacillus subtilis FRK (EC 2.7.1.4), also called glucomannan utilization protein E, catalyzes the phosphorylation of fructose to fructose-6-P. It seems to be involved in the degradation of glucomannan. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466917 [Multi-domain]  Cd Length: 285  Bit Score: 52.16  E-value: 1.82e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 131 ISAIESFIDQNQRRIReliAISV-----IIPGLVDPDEGIIRYMPHIKVDNWPLVYNLKNHFKTFCFIGHDIRSLALAEN 205
Cdd:cd24067    37 LQAVIDFFREQEEPID---AIGIasfgpIDLNPTSPTYGYITTTPKPGWRNFDILGALKRAFPVPVGFDTDVNAAALAEY 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 206 YFGATRDCEDSILVRIHRGTGAGVIVNNNILlnkrGNLG--EIGHIQIEPLGERCH----C---GNfgCLETIVSNSAIE 276
Cdd:cd24067   114 RWGAAKGLDSLAYITVGTGIGVGLVVNGKPV----HGLLhpEMGHIRVPRHPDDDGfpgvCpfhGD--CLEGLASGPAIA 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 277 TRVqhqlrqgfpsqltlnncNIHAICLAANagDPlATEIIrqaGHYLGKAISITINLFNPQKVVIAGEIAEAKQvLLPAi 356
Cdd:cd24067   188 ARW-----------------GIPAEELPDD--HP-AWDLE---AYYLAQACANLTLTLSPERIVLGGGVMQRPG-LFPR- 242

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 2189429128 357 qncINKQVLKAFREELPV-----------VVSEL-NHCSAIGAFAL 390
Cdd:cd24067   243 ---IREKFRKLLNGYLEVprllpdideyiVPPALgNDAGILGALAL 285
PRK13311 PRK13311
N-acetyl-D-glucosamine kinase; Provisional
 104-289 2.33e-07

N-acetyl-D-glucosamine kinase; Provisional


Pssm-ID: 106271 [Multi-domain]  Cd Length: 256  Bit Score: 51.57  E-value: 2.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 104 FDMSGKTLteERYAILENTQQEVEKRIISAIESFiDQNQRRIRELI-----------AISVIIPGLVDPDEGIIRYMPHI 172
Cdd:PRK13311    5 FDMGGTKI--ELGVFDENLQRIWHKRVPTPREDY-PQLLQILRDLTeeadtycgvqgSVGIGIPGLPNADDGTVFTANVP 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 173 KVDNWPLVYNLKNHFKTFCFIGHDIRSLALAENYFGATRDCEDSILVRIHRGTGAGVIVNNNILLNKRGNLGEIGHIQI- 251
Cdd:PRK13311   82 SAMGQPLQADLSRLIQREVRIDNDANCFALSEAWDPEFRTYPTVLGLILGTGVGGGLIVNGSIVSGRNHITGEFGHFRLp 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 2189429128 252 ----EPLGER-----CHCGNFGCLETIVSNSAIETRVQHQLRQGFPS 289
Cdd:PRK13311  162 vdalDILGADiprvpCGCGHRGCIENYISGRGFEWMYSHFYQHTLPA 208
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
26-88 1.53e-06

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 46.43  E-value: 1.53e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2189429128   26 RLIDQHGPISRIQIAEESQLAPASVTKITRQLLERGLIkevEHQASTGGRRA--ISIVTESRHFH 88
Cdd:smart00347  17 RILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLV---RREPSPEDRRSvlVSLTEEGRELI 78
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 23-78 3.82e-06

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 44.08  E-value: 3.82e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2189429128  23 VVYRLIDQHGPISRIQIAEESQLAPASVTKITRQLLERGLIkevEHQASTGGRRAI 78
Cdd:pfam01047   7 HILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLI---ERSRSPEDRREV 59
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
23-86 6.25e-05

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 42.50  E-value: 6.25e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2189429128  23 VVYRLIDQHGPISRIQIAEESQLAPASVTKITRQLLERGLIKEVEHQAST----GGRRAISIVTesRH 86
Cdd:COG1321    14 AIYELSEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEPYGGITlteeGRELALRIVR--RH 79
Fe_dep_repress pfam01325
Iron dependent repressor, N-terminal DNA binding domain; This family includes the Diphtheria ...
 23-64 1.54e-04

Iron dependent repressor, N-terminal DNA binding domain; This family includes the Diphtheria toxin repressor. DNA binding is through a helix-turn-helix motif.


Pssm-ID: 396062 [Multi-domain]  Cd Length: 57  Bit Score: 39.28  E-value: 1.54e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2189429128  23 VVYRLIDQHGPISRIQIAEESQLAPASVTKITRQLLERGLIK 64
Cdd:pfam01325   9 TIYTLSEEKGVVKTKDLAERLNVSPSTVSEMLKKLEKMGYVD 50
BadF COG2971
BadF-type ATPase, related to human N-acetylglucosamine kinase [Carbohydrate transport and ...
 304-363 1.77e-04

BadF-type ATPase, related to human N-acetylglucosamine kinase [Carbohydrate transport and metabolism];


Pssm-ID: 442210 [Multi-domain]  Cd Length: 298  Bit Score: 42.95  E-value: 1.77e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128 304 AANAGDPLATEIIRQAGHYLGKAIsITINLFNPQKVVIAGEIAEAKQVLLPAIQNCINKQ 363
Cdd:COG2971   215 AAEAGDPVARAILEEAADELAELA-RALLERGALPVVLAGGVAAAQPLLREALRARLAAG 273
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
26-81 9.04e-04

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 39.18  E-value: 9.04e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2189429128  26 RLIDQHGPISRIQIAEESQLAPASVTKITRQLLERGLikeVEHQASTGGRRAISIV 81
Cdd:COG1846    45 AALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGL---VEREPDPEDRRAVLVR 97
ASKHA_NBD_GspK-like cd24082
nucleotide-binding domain (NBD) of Vibrio cholerae glucosamine kinase GspK and similar ...
 304-355 2.21e-03

nucleotide-binding domain (NBD) of Vibrio cholerae glucosamine kinase GspK and similar proteins; The family includes a group of uncharacterized proteins similar to Vibrio cholerae glucosamine kinase GspK (EC 2.7.1.8), also called GlcN kinase. It acts as ATP-dependent kinase, which is specific for glucosamine. GspK does not show kinase activity with any other sugar.


Pssm-ID: 466932 [Multi-domain]  Cd Length: 279  Bit Score: 39.44  E-value: 2.21e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2189429128 304 AANAGDPLATEIIRQAGHYLGKAISiTINLFNPQKVVIAGEIAEAKQVLLPA 355
Cdd:cd24082   209 AAEQGDPVALAILQEAAAYIERLLR-ALGAQGALPLCLLGGLAERLAPYLPE 259
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
24-151 2.37e-03

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 39.14  E-value: 2.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189429128  24 VYRLIDQHGPISRIQIAEESQLAPASVtkitRQ----LLERGLIkEVEHQASTGGRRAI--SIVTESRHfhtigiRLGRH 97
Cdd:COG2345    18 ILELLKRAGPVTAAELAEALGLTPNAV----RRhldaLEEEGLV-ERETERRGRGRPAKlyRLTEAGRA------RFPRA 86

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2189429128  98 DATLA--LFDMSGKTLTEER-YAILENTQQEVEKRIISAIESFIDQnQRRIRELIAI 151
Cdd:COG2345    87 YDDLAvaLLDALRELLGEDAvERLARARGRRLAARYRPALAGAGSL-EERLEALAEL 142
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 28-77 9.27e-03

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 34.49  E-value: 9.27e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2189429128  28 IDQHGPISRIQIAEESQLAPASVTKITRQLLERGLikeVEHQASTGGRRA 77
Cdd:pfam12802  14 LARNPGLTVAELARRLGISKQTVSRLVKRLEAKGL---VEREPSPADRRA 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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