|
Name |
Accession |
Description |
Interval |
E-value |
| YfaS |
COG2373 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
495-1841 |
0e+00 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 1248.82 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191078338 495 YQYNDLASSTRAFLASNLGLIAKQGqNNQLYVMASSLDGNQPLKGVALTAYNYQLQRIGEGHTDKDGMATLTLDG----- 569
Cdd:COG2373 250 YSYNGESRATQWFLVSDLGLTAKRG-DDGLLVFVTSLSTGKPVAGAEVELYDRNGQVLATATTDADGLARFPAGDrgegg 328
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191078338 570 -TAYYLQASRDKDVGYLKLARNRALPTNQFNTGGEQVRDGLKGFFYGERDVWRPGDDIHLTFILQDKQHRIPDDHPLTLD 648
Cdd:COG2373 329 rAPALLVARKGGDFAFLDLDDGPALDLSDFDVGGRAPPGGLDAFLFTDRGIYRPGETVHLKALLRDADGKAPAGLPLTLE 408
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191078338 649 WFDPRGNKVKSYTLDKPVGNFYAFTLHTDEQAPTGNWRAVARLG--QRYFDTPVRVEAIKPNRLKIELGLP-EWLHANQG 725
Cdd:COG2373 409 LTDPDGKEVRRQTLTLNEFGGYSFSFPLPEDAPTGTWRLELYVDpkPALGSKSFRVEEFKPPRFKVDLTLDkEPLKPGDP 488
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191078338 726 EPVTLFSQWLNGATASRLKADVKVRVSGRATTFDGYQAYHFDDPTRALKSEPFTAFDGQLDASGNASFPLQVP-VEQAPG 804
Cdd:COG2373 489 VTVTVDARYLFGAPAAGLKVEGEVTLRPARTAFPGYPGYRFGDPDEEFEPEELDLGEGTLDADGKASLSLPLPdAPDAPG 568
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191078338 805 MVRAVLTTRVFENSGDYSTQVRSVPVYPYHHWVGMKVPRGSGWgdslSRDEKHGIDLVSLDSDGKPDPDRALDITVYRID 884
Cdd:COG2373 569 PLRATVEASVFESGGRPVTRSATVPVHPADFYVGIRLPLFDGD----PEGAPATFEVVAVDPDGKPVAGKGLKVELYREE 644
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191078338 885 WRWWWDRSDDKLTNFISDPNTKEVTRAHVTTDQDGHAlwQLDGADYDWGRHLIRVCEQDGQHCTAQTVYLGWSwdqAAGS 964
Cdd:COG2373 645 WRYVWYKSDDGGWRYESQEKEEPVAEGTLTTGADGPA--SLSLTPVEWGRYRLEVKDPDGGLATSVRFYAGGN---ASWG 719
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191078338 965 QDAATRLSLSADKPRYQVGDTAHIELPSVASGRLLVSLEtGSRVLDHYWLPATGQAQTLDIPVTAEMAPNVYVNVALLQP 1044
Cdd:COG2373 720 AERPDRLELSLDKESYKPGETAKLLIQSPFAGRALVTVE-RDGVLETQWVDVKGGGTTVEIPVTEDWAPNAYVSATLVRP 798
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191078338 1045 H-QRDNDRPIRLYGVVPLLVDDPATRLTPQIKAPEQVKPGQTFSVAVSEK--QGHAMTYTLAVVDEGLLGLTNFRTPDPH 1121
Cdd:COG2373 799 GdSTANDMPARAYGVAPLPVDPPARRLKVELTAPEKLRPGETLTVTVKVKgaAGKAAEVTLAAVDEGILNLTGYKTPDPL 878
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191078338 1122 DAFYKREALGVLTWDLYDMVVGAYGAeLDQLLALGGSDALEDG--HEKQRRRFPPVVKFLGPFQLDDNETAHHSITLPAY 1199
Cdd:COG2373 879 DFFYGKRALGVETRDLYGRLIGAFGG-AAGALRSGGDGALGRGgnPKPPRKRFKPVALFSGPVKTDADGKATVSFDLPDF 957
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191078338 1200 MGQVRVMVVAGTDSAYGKASQDVTVTQPLTLLSTLPRVMGPGESVALPVTVFVTDDNLKTVNLSVKADDALFTVEQGSAT 1279
Cdd:COG2373 958 NGTLRVMAVAWSDDRFGSAEATVTVRKPLVVRPSLPRFLAPGDRFELPVDVFNLTGKAGTVTVTLEASGGLTLEGEATQT 1037
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191078338 1280 LHFDGSGDQIAMLRLHAnKQVGKGQVTVTARAGDQQATETVTLPVRAANPPTTREQRHVLQAGETWAGQFMPHG--LPGT 1357
Cdd:COG2373 1038 VTLAAGGRATVRFPLKA-PDAGDAKVTVTATGGGESDAREVELPVRPANPLVTRATSGVLAPGESWTLPLDLPGglRPGT 1116
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191078338 1358 NAGTLTVSTLPAMGLERRLNYLLNYPHGCIEQTTSAVLPQLYLPQLV---NLSDEQQQTLQKNVEAGIARLRHFQLTDGG 1434
Cdd:COG2373 1117 GSLTLSLSSSPPLDLAGLLRYLLRYPYGCTEQTTSRALPLLYLSDLAealGLKGDKDAELRARIQAAIARLLSMQNSDGG 1196
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191078338 1435 FSYWPGLASASDWGTSYAGHFLLEARRLGYAVPAQMLEDWQRYQIRR----TQTLGQRPWEWSAEAYRLYTLALAGKPQV 1510
Cdd:COG2373 1197 FGLWPGGSESDPWLTAYATDFLLEAREAGYAVPDDALDRALDYLRNYlrnpWEIEYDDAYRLAVRAYALYVLARAGKADL 1276
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191078338 1511 GAMNRLRERlnladkdYGRWASYhNGRWLLAAAYQQMGLSPVAAELIA-GESAVV---PYQAPGYTYGSSLRDQAIRL-T 1585
Cdd:COG2373 1277 GDLRYLYDR-------RKDALSP-LAKAQLAAALALLGDKARAEELLAaALARLRetgARDYWYGDYGSPLRDQALALaL 1348
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191078338 1586 VKEGAGDDNGAWELADDVAASLASERWYSTQSTAWALMAMARYAGGKEGDEGYRFAWR-DGKQswQDLQARSPVYQQALQ 1664
Cdd:COG2373 1349 LAELGPDAPLAPKLARWLAKALKSGRWLSTQETAWALLALAAYARAAGASPDFTATLTlDGKT--LPLTGRGPLARVTLP 1426
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191078338 1665 GDDY--RGVAVRNDSERKLFVTLSNTGTPPPGQEQPVSDGLRLNARFSDDNGQAVNPTTLTQGTDFHARVVVTNTSGReL 1742
Cdd:COG2373 1427 AAELlaGPLTITNTGDGPLYYTLTLSGYPAEGPPPAASNGLEIERRYYDLDGKPIDPASLKQGDLVVVRLTVTAPSGR-V 1505
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191078338 1743 KNLALTQILPSGWQITSSRLSGSAEQQD-DKDQPPVTYQDLRDDRVLSYFDLPAGKSISLSVDLNASFAGHYYLPAWTVE 1821
Cdd:COG2373 1506 ENVAVVDPLPAGFEIENPRLATSGDLGDwLGDSWQPDHQEFRDDRVVAAFDLDPAGTYTFAYLVRAVTPGTFVLPPAQAE 1585
|
1370 1380
....*....|....*....|
gi 2191078338 1822 AMYDGSKQARSAGQWVTVKP 1841
Cdd:COG2373 1586 DMYRPEVRARSAGGRVTVVA 1605
|
|
| A2M_like |
cd02891 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier ... |
1372-1628 |
1.08e-41 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. This group contains another broadly specific proteinase inhibitor: pregnancy zone protein (PZP). PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system. This group also contains C3, C4 and C5 of vertebrate complement. The vertebrate complement is an effector of both the acquired and innate immune systems The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Pssm-ID: 239221 [Multi-domain] Cd Length: 282 Bit Score: 155.24 E-value: 1.08e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191078338 1372 LERRLNYLLNYPHGCIEQTTSAVLPQLYLPQLVN----LSDEQQQTLQKNVEAGIARLRHFQLTDGGFSYWPGLASASDW 1447
Cdd:cd02891 1 SLGNLDYLLRYPYGCGEQTMSRAAPNLYVLKYLDatgqLTPEIREKALEYIRKGYQRLLTYQRSDGSFSAWGNSDSGSTW 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191078338 1448 GTSYAGHFLLEARR------------LGYAVPAQMLEDW---QRYQIRRTQTLGQRPwEWSAEAYRLYTLALAGK----P 1508
Cdd:cd02891 81 LTAYVVKFLSQARKyidvdenvlaraLGWLVPQQKEDGSfreLGPVIHREMKGGVDD-SVSLTAYVLIALAEAGKacdaS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191078338 1509 QVGAMNRLRERLNLADKDYgrwasyhnGRWLLAAAYQQMGLSPVAAEL--------IAGESAVVPYQAPGYTYGSSLRDQ 1580
Cdd:cd02891 160 IEKALAYLETQLDGLLDPY--------ALAILAYALALAGDSTRADEAlkklleaaREKGGTAHWSLSWPGDYGSSLRVE 231
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 2191078338 1581 AIRL----TVKEGAGDDngawelADDVAASLASER-----WYSTQSTAWALMAMARY 1628
Cdd:cd02891 232 ATAYallaLLKLGDLEE------AGPIAKWLAQQRnsgggFLSTQDTVVALQALAAY 282
|
|
| A2M_BRD |
pfam07703 |
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins ... |
971-1112 |
1.40e-28 |
|
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain encompasses macroglobulin-like domain MG5 and 6 including bait region. In Salmonella enterica ser A2Ms, this domain encompasses MG7 and MG8 including the bait region. The Bait region is cleaved by proteases, followed by a large conformational change that blocks the target protease within a cage-like complex. This model of protease entrapment is recognized as the Venus flytrap mechanism.
Pssm-ID: 462235 [Multi-domain] Cd Length: 139 Bit Score: 112.44 E-value: 1.40e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191078338 971 LSLSADKPRYQVGDTAHIELPSVASGRLLVSLETgSRVLDHYWLPATGQAQ---TLDIPVTAEMAPNVYVNVALLQPhqr 1047
Cdd:pfam07703 1 LHLSTDKTEYKPGETATVTVKSPFDGTVERDGFT-YLVLSKGQIVVVGRGGvttSFSLPVTAEMAPSARVVAYYVRV--- 76
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2191078338 1048 DNDRPIRLYGVVPLLVDDPATR-LTPQIKaPEQVKPGQTFSVAVSEKQGhaMTYTLAVVDEGLLGL 1112
Cdd:pfam07703 77 DLSKPEVVADSVWVDVDDTCENkLKVTLS-AEKYRPGSTVELKVKADPG--AYVALAAVDKGVLLL 139
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| YfaS |
COG2373 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
495-1841 |
0e+00 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 1248.82 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191078338 495 YQYNDLASSTRAFLASNLGLIAKQGqNNQLYVMASSLDGNQPLKGVALTAYNYQLQRIGEGHTDKDGMATLTLDG----- 569
Cdd:COG2373 250 YSYNGESRATQWFLVSDLGLTAKRG-DDGLLVFVTSLSTGKPVAGAEVELYDRNGQVLATATTDADGLARFPAGDrgegg 328
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191078338 570 -TAYYLQASRDKDVGYLKLARNRALPTNQFNTGGEQVRDGLKGFFYGERDVWRPGDDIHLTFILQDKQHRIPDDHPLTLD 648
Cdd:COG2373 329 rAPALLVARKGGDFAFLDLDDGPALDLSDFDVGGRAPPGGLDAFLFTDRGIYRPGETVHLKALLRDADGKAPAGLPLTLE 408
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191078338 649 WFDPRGNKVKSYTLDKPVGNFYAFTLHTDEQAPTGNWRAVARLG--QRYFDTPVRVEAIKPNRLKIELGLP-EWLHANQG 725
Cdd:COG2373 409 LTDPDGKEVRRQTLTLNEFGGYSFSFPLPEDAPTGTWRLELYVDpkPALGSKSFRVEEFKPPRFKVDLTLDkEPLKPGDP 488
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191078338 726 EPVTLFSQWLNGATASRLKADVKVRVSGRATTFDGYQAYHFDDPTRALKSEPFTAFDGQLDASGNASFPLQVP-VEQAPG 804
Cdd:COG2373 489 VTVTVDARYLFGAPAAGLKVEGEVTLRPARTAFPGYPGYRFGDPDEEFEPEELDLGEGTLDADGKASLSLPLPdAPDAPG 568
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191078338 805 MVRAVLTTRVFENSGDYSTQVRSVPVYPYHHWVGMKVPRGSGWgdslSRDEKHGIDLVSLDSDGKPDPDRALDITVYRID 884
Cdd:COG2373 569 PLRATVEASVFESGGRPVTRSATVPVHPADFYVGIRLPLFDGD----PEGAPATFEVVAVDPDGKPVAGKGLKVELYREE 644
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191078338 885 WRWWWDRSDDKLTNFISDPNTKEVTRAHVTTDQDGHAlwQLDGADYDWGRHLIRVCEQDGQHCTAQTVYLGWSwdqAAGS 964
Cdd:COG2373 645 WRYVWYKSDDGGWRYESQEKEEPVAEGTLTTGADGPA--SLSLTPVEWGRYRLEVKDPDGGLATSVRFYAGGN---ASWG 719
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191078338 965 QDAATRLSLSADKPRYQVGDTAHIELPSVASGRLLVSLEtGSRVLDHYWLPATGQAQTLDIPVTAEMAPNVYVNVALLQP 1044
Cdd:COG2373 720 AERPDRLELSLDKESYKPGETAKLLIQSPFAGRALVTVE-RDGVLETQWVDVKGGGTTVEIPVTEDWAPNAYVSATLVRP 798
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191078338 1045 H-QRDNDRPIRLYGVVPLLVDDPATRLTPQIKAPEQVKPGQTFSVAVSEK--QGHAMTYTLAVVDEGLLGLTNFRTPDPH 1121
Cdd:COG2373 799 GdSTANDMPARAYGVAPLPVDPPARRLKVELTAPEKLRPGETLTVTVKVKgaAGKAAEVTLAAVDEGILNLTGYKTPDPL 878
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191078338 1122 DAFYKREALGVLTWDLYDMVVGAYGAeLDQLLALGGSDALEDG--HEKQRRRFPPVVKFLGPFQLDDNETAHHSITLPAY 1199
Cdd:COG2373 879 DFFYGKRALGVETRDLYGRLIGAFGG-AAGALRSGGDGALGRGgnPKPPRKRFKPVALFSGPVKTDADGKATVSFDLPDF 957
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191078338 1200 MGQVRVMVVAGTDSAYGKASQDVTVTQPLTLLSTLPRVMGPGESVALPVTVFVTDDNLKTVNLSVKADDALFTVEQGSAT 1279
Cdd:COG2373 958 NGTLRVMAVAWSDDRFGSAEATVTVRKPLVVRPSLPRFLAPGDRFELPVDVFNLTGKAGTVTVTLEASGGLTLEGEATQT 1037
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191078338 1280 LHFDGSGDQIAMLRLHAnKQVGKGQVTVTARAGDQQATETVTLPVRAANPPTTREQRHVLQAGETWAGQFMPHG--LPGT 1357
Cdd:COG2373 1038 VTLAAGGRATVRFPLKA-PDAGDAKVTVTATGGGESDAREVELPVRPANPLVTRATSGVLAPGESWTLPLDLPGglRPGT 1116
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191078338 1358 NAGTLTVSTLPAMGLERRLNYLLNYPHGCIEQTTSAVLPQLYLPQLV---NLSDEQQQTLQKNVEAGIARLRHFQLTDGG 1434
Cdd:COG2373 1117 GSLTLSLSSSPPLDLAGLLRYLLRYPYGCTEQTTSRALPLLYLSDLAealGLKGDKDAELRARIQAAIARLLSMQNSDGG 1196
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191078338 1435 FSYWPGLASASDWGTSYAGHFLLEARRLGYAVPAQMLEDWQRYQIRR----TQTLGQRPWEWSAEAYRLYTLALAGKPQV 1510
Cdd:COG2373 1197 FGLWPGGSESDPWLTAYATDFLLEAREAGYAVPDDALDRALDYLRNYlrnpWEIEYDDAYRLAVRAYALYVLARAGKADL 1276
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191078338 1511 GAMNRLRERlnladkdYGRWASYhNGRWLLAAAYQQMGLSPVAAELIA-GESAVV---PYQAPGYTYGSSLRDQAIRL-T 1585
Cdd:COG2373 1277 GDLRYLYDR-------RKDALSP-LAKAQLAAALALLGDKARAEELLAaALARLRetgARDYWYGDYGSPLRDQALALaL 1348
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191078338 1586 VKEGAGDDNGAWELADDVAASLASERWYSTQSTAWALMAMARYAGGKEGDEGYRFAWR-DGKQswQDLQARSPVYQQALQ 1664
Cdd:COG2373 1349 LAELGPDAPLAPKLARWLAKALKSGRWLSTQETAWALLALAAYARAAGASPDFTATLTlDGKT--LPLTGRGPLARVTLP 1426
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191078338 1665 GDDY--RGVAVRNDSERKLFVTLSNTGTPPPGQEQPVSDGLRLNARFSDDNGQAVNPTTLTQGTDFHARVVVTNTSGReL 1742
Cdd:COG2373 1427 AAELlaGPLTITNTGDGPLYYTLTLSGYPAEGPPPAASNGLEIERRYYDLDGKPIDPASLKQGDLVVVRLTVTAPSGR-V 1505
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191078338 1743 KNLALTQILPSGWQITSSRLSGSAEQQD-DKDQPPVTYQDLRDDRVLSYFDLPAGKSISLSVDLNASFAGHYYLPAWTVE 1821
Cdd:COG2373 1506 ENVAVVDPLPAGFEIENPRLATSGDLGDwLGDSWQPDHQEFRDDRVVAAFDLDPAGTYTFAYLVRAVTPGTFVLPPAQAE 1585
|
1370 1380
....*....|....*....|
gi 2191078338 1822 AMYDGSKQARSAGQWVTVKP 1841
Cdd:COG2373 1586 DMYRPEVRARSAGGRVTVVA 1605
|
|
| A2M_like |
cd02891 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier ... |
1372-1628 |
1.08e-41 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. This group contains another broadly specific proteinase inhibitor: pregnancy zone protein (PZP). PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system. This group also contains C3, C4 and C5 of vertebrate complement. The vertebrate complement is an effector of both the acquired and innate immune systems The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Pssm-ID: 239221 [Multi-domain] Cd Length: 282 Bit Score: 155.24 E-value: 1.08e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191078338 1372 LERRLNYLLNYPHGCIEQTTSAVLPQLYLPQLVN----LSDEQQQTLQKNVEAGIARLRHFQLTDGGFSYWPGLASASDW 1447
Cdd:cd02891 1 SLGNLDYLLRYPYGCGEQTMSRAAPNLYVLKYLDatgqLTPEIREKALEYIRKGYQRLLTYQRSDGSFSAWGNSDSGSTW 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191078338 1448 GTSYAGHFLLEARR------------LGYAVPAQMLEDW---QRYQIRRTQTLGQRPwEWSAEAYRLYTLALAGK----P 1508
Cdd:cd02891 81 LTAYVVKFLSQARKyidvdenvlaraLGWLVPQQKEDGSfreLGPVIHREMKGGVDD-SVSLTAYVLIALAEAGKacdaS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191078338 1509 QVGAMNRLRERLNLADKDYgrwasyhnGRWLLAAAYQQMGLSPVAAEL--------IAGESAVVPYQAPGYTYGSSLRDQ 1580
Cdd:cd02891 160 IEKALAYLETQLDGLLDPY--------ALAILAYALALAGDSTRADEAlkklleaaREKGGTAHWSLSWPGDYGSSLRVE 231
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 2191078338 1581 AIRL----TVKEGAGDDngawelADDVAASLASER-----WYSTQSTAWALMAMARY 1628
Cdd:cd02891 232 ATAYallaLLKLGDLEE------AGPIAKWLAQQRnsgggFLSTQDTVVALQALAAY 282
|
|
| A2M_BRD |
pfam07703 |
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins ... |
971-1112 |
1.40e-28 |
|
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain encompasses macroglobulin-like domain MG5 and 6 including bait region. In Salmonella enterica ser A2Ms, this domain encompasses MG7 and MG8 including the bait region. The Bait region is cleaved by proteases, followed by a large conformational change that blocks the target protease within a cage-like complex. This model of protease entrapment is recognized as the Venus flytrap mechanism.
Pssm-ID: 462235 [Multi-domain] Cd Length: 139 Bit Score: 112.44 E-value: 1.40e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191078338 971 LSLSADKPRYQVGDTAHIELPSVASGRLLVSLETgSRVLDHYWLPATGQAQ---TLDIPVTAEMAPNVYVNVALLQPhqr 1047
Cdd:pfam07703 1 LHLSTDKTEYKPGETATVTVKSPFDGTVERDGFT-YLVLSKGQIVVVGRGGvttSFSLPVTAEMAPSARVVAYYVRV--- 76
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2191078338 1048 DNDRPIRLYGVVPLLVDDPATR-LTPQIKaPEQVKPGQTFSVAVSEKQGhaMTYTLAVVDEGLLGL 1112
Cdd:pfam07703 77 DLSKPEVVADSVWVDVDDTCENkLKVTLS-AEKYRPGSTVELKVKADPG--AYVALAAVDKGVLLL 139
|
|
| bMG3 |
pfam11974 |
Bacterial alpha-2-macroglobulin MG3 domain; This is the MG3 domain from bacterial ... |
509-604 |
5.63e-21 |
|
Bacterial alpha-2-macroglobulin MG3 domain; This is the MG3 domain from bacterial alpha2-macroglobulins.
Pssm-ID: 432232 [Multi-domain] Cd Length: 102 Bit Score: 89.58 E-value: 5.63e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191078338 509 ASNLGLIAKQGQNNqLYVMASSLDGNQPLKGVALTAYNYQLQRIGEGHTDKDGMATLTL------DGTAYYLQASRDKDV 582
Cdd:pfam11974 1 VSDLGLHAKQGRDG-LLVWVTSLDSGKPVAGVEVRLLDCNGQVLATGTTDAQGHARFEGpltrdgGAAPALVSARKDGDF 79
|
90 100
....*....|....*....|..
gi 2191078338 583 GYLKLARNRALPTNQFNTGGEQ 604
Cdd:pfam11974 80 AFLRLDWGPALDLSDFDVGGRP 101
|
|
| ISOPREN_C2_like |
cd00688 |
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ... |
1372-1628 |
4.20e-20 |
|
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.
Pssm-ID: 238362 [Multi-domain] Cd Length: 300 Bit Score: 93.00 E-value: 4.20e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191078338 1372 LERRLNYLLNYPHG--------CIEQTTSAVLPQLYLPQLVNLSDEQQQTlQKNVEAGIARLRHFQLTDGGFSYWPGLAS 1443
Cdd:cd00688 1 IEKHLKYLLRYPYGdghwyqslCGEQTWSTAWPLLALLLLLAATGIRDKA-DENIEKGIQRLLSYQLSDGGFSGWGGNDY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191078338 1444 ASDWGTSYAGHFLLEARR------------LGYAVPAQMlED--WQRYQIRRTQTLGQRPwEWSAEAYRLYTLALAGKPQ 1509
Cdd:cd00688 80 PSLWLTAYALKALLLAGDyiavdridlaraLNWLLSLQN-EDggFREDGPGNHRIGGDES-DVRLTAYALIALALLGKLD 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191078338 1510 V-----GAMNRLRERLNlADKDYGRWASYH-NGRWLLAAAYQQMG--LSPVAAELIA-------GESAVVPYQAPGYTYG 1574
Cdd:cd00688 158 PdplieKALDYLLSCQN-YDGGFGPGGESHgYGTACAAAALALLGdlDSPDAKKALRwllsrqrPDGGWGEGRDRTNKLS 236
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2191078338 1575 SSLRDQAIRLTVKegAGDDNGAWELADDVAASLASER-----WYS-------TQSTAWALMAMARY 1628
Cdd:cd00688 237 DSCYTEWAAYALL--ALGKLGDLEDAEKLVKWLLSQQnedggFSSkpgksydTQHTVFALLALSLY 300
|
|
| bMG6 |
pfam17962 |
Bacterial macroglobulin domain 6; This macroglobulin domain is found in bacterial alpha 2 ... |
848-956 |
3.56e-19 |
|
Bacterial macroglobulin domain 6; This macroglobulin domain is found in bacterial alpha 2 macroglobulin proteins. It adopts an Ig-like beta sandwich fold.
Pssm-ID: 436175 Cd Length: 112 Bit Score: 84.61 E-value: 3.56e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191078338 848 GDSLSRDEKHGIDLVSLDSDGKPDPDRALDITVYRIDWRWWWDRSDDkLTNFISDPNTKEVTRAHVTTDQDGHALWQLdg 927
Cdd:pfam17962 8 DGSLEEGKEAAFEVVAVDADGKPVAVQGLEWTLYREEWDYQWYRQDG-GWSYEPVTRDKRVATGTVDTGADGPATISL-- 84
|
90 100
....*....|....*....|....*....
gi 2191078338 928 aDYDWGRHLIRVCEQDGQHCTAQTVYLGW 956
Cdd:pfam17962 85 -PVDWGRYRLEVEDPGGGAATSVRFYAGW 112
|
|
| MG2 |
pfam01835 |
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. ... |
610-702 |
3.85e-19 |
|
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain is termed macroglobulin-like (MG) domain 2 and in Salmonella enterica ser A2Ms, this is domain 4.
Pssm-ID: 426464 [Multi-domain] Cd Length: 95 Bit Score: 83.90 E-value: 3.85e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191078338 610 KGFFYGERDVWRPGDDIHLTFILQDKQHRIPDDHPLTLDWFDPRGNKVKSYTLDKPVGNFYAFTLHTDEQAPTGNWRAVA 689
Cdd:pfam01835 1 RAFVYTDRGIYRPGETVHFKGLLRDQDLRPLAGLPVTLTVTDPDGNEVRRLPLTTDEFGGFSGSFPLPETAPTGTYTVVL 80
|
90
....*....|....*
gi 2191078338 690 R--LGQRYFDTPVRV 702
Cdd:pfam01835 81 RdgAGGSLGSGSFRV 95
|
|
| bMG10 |
pfam17973 |
Bacterial Alpha-2-macroglobulin MG10 domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins ... |
1702-1825 |
8.64e-13 |
|
Bacterial Alpha-2-macroglobulin MG10 domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. Bacterial A2Ms are located in the periplasm where they are believed to provide protection to the cell by trapping external proteases through a covalent interaction with an activated thioester. This domain is found on the C-terminal region in A2Ms in bacteria. Structure analysis of Salmonella enterica ser A2Ms (SA-A2Ms) show that they are composed of 13 domains, all of which fold as variants of beta sandwiches with the exception of the TED, which consists of 14 alpha helices. Most of the beta sandwich domains appear to serve a structural role and are referred to as the macroglobulin-like (MG) domains. This is the MG10 domain. MG10 is markedly different from the other MG domains in that it has more beta strands and an alpha helix. The position of MG10 is stabilized by, in addition to other hydrogen bonds, the formation of a beta sheet with MG9.
Pssm-ID: 465598 Cd Length: 128 Bit Score: 66.94 E-value: 8.64e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191078338 1702 GLRLNARFSDDNGQAVNP---TTLTQGTDFhaRVVVTNTSGRELKNLALTQILPSGWQIT---SSRLSGSAEQQDDKDQP 1775
Cdd:pfam17973 1 GLSVTRRFYVLEGSGVSAsdaETLKVGDKV--RVRLTVTTDRDRDFVALEDPLPAGLEPVnplSGYTWEGGLGYPDNTQP 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 2191078338 1776 PvtYQDLRDDRVLSYFD-LPAGKSiSLSVDLNASFAGHYYLPAWTVEAMYD 1825
Cdd:pfam17973 79 S--YREVRDDRVRFFADyLPKGTY-TFEYLVRAVTPGTFTVPPATAESMYA 126
|
|
| bMG5 |
pfam17972 |
Bacterial Alpha-2-macroglobulin MG5 domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins ... |
709-819 |
1.76e-12 |
|
Bacterial Alpha-2-macroglobulin MG5 domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. Bacterial A2Ms are located in the periplasm where they are believed to provide protection to the cell by trapping external proteases through a covalent interaction with an activated thioester. This domain is found on the N-terminal region in A2Ms in bacteria. Structure analysis of Salmonella enterica ser A2Ms (SA-A2Ms) show that they are composed of 13 domains, all of which fold as variants of beta sandwiches with the exception of the TED, which consists of 14 alpha helices. Most of the beta sandwich domains appear to serve a structural role and are referred to as the macroglobulin-like (MG) domains. This is the MG5 domain.
Pssm-ID: 436183 Cd Length: 127 Bit Score: 66.00 E-value: 1.76e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191078338 709 RLKIELGLPEwLHANQGEPVTLFSQ--WLNGATASRLKADVKVRVSGRATTFDGYQAYHFDDPTRALKSEPFTAFDGQLD 786
Cdd:pfam17972 2 RMDLDLSLPD-APLAPGDPAELDVDarYLYGAPAAGLRLEGELTLRPARHALAGFPGYRFGRHDEELLKRTRDLPDLTTD 80
|
90 100 110
....*....|....*....|....*....|....
gi 2191078338 787 ASGNASFPLQVPVEQAPGM-VRAVLTTRVFENSG 819
Cdd:pfam17972 81 AQGKATLTVPLPEWPAATRpLEARVTVSLLESGG 114
|
|
| A2M |
pfam00207 |
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ... |
1181-1265 |
2.33e-07 |
|
Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.
Pssm-ID: 459711 [Multi-domain] Cd Length: 91 Bit Score: 50.28 E-value: 2.33e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191078338 1181 PFQLDDNETAHHSITLPAYMGQVRVMVVA-GTDSAYGKAS-QDVTVTQPLTLLSTLPRVMGPGESVALPVTVFvtddNLK 1258
Cdd:pfam00207 6 PVLVTDNGKASLSFTLPDSITTWRATAFAlSPDTGLGVAEpPELVVFKPFFVDLNLPYSVRRGEQFELKATVF----NYL 81
|
....*..
gi 2191078338 1259 TVNLSVK 1265
Cdd:pfam00207 82 DKCLKVR 88
|
|
| complement_C3_C4_C5 |
cd02896 |
Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, ... |
1376-1451 |
1.10e-04 |
|
Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Pssm-ID: 239226 [Multi-domain] Cd Length: 297 Bit Score: 46.11 E-value: 1.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191078338 1376 LNYLLNYPHGCIEQTTSAVLPQLYL-------PQLVNLSDEQQQTLQKNVEAGIARLRHFQLTDGGFSYWPGLASaSDWG 1448
Cdd:cd02896 5 LEKLIRLPTGCGEQTMIKLAPTVYAlryldttNQWEKLGPERRDEALKYIRQGYQRQLSYRKPDGSYAAWKNRPS-STWL 83
|
...
gi 2191078338 1449 TSY 1451
Cdd:cd02896 84 TAF 86
|
|
| TED_complement |
pfam07678 |
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement ... |
1376-1461 |
3.99e-03 |
|
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.
Pssm-ID: 462227 [Multi-domain] Cd Length: 311 Bit Score: 41.52 E-value: 3.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191078338 1376 LNYLLNYPHGCIEQTTSAVLPQLYLPQLVNLSD----EQQQTLQKNVEAGIARLRHFQLTDGGFSYWpGLASASDWGTSY 1451
Cdd:pfam07678 19 LSSLLRLPYGCGEQNMVLFAPNVYVLRYLDKTNqltkLIKSKAIDYLEQGYQRQLSYKHPDGSYSAF-GHSPGSTWLTAF 97
|
90
....*....|
gi 2191078338 1452 AGHFLLEARR 1461
Cdd:pfam07678 98 VLKVFAQARK 107
|
|
| |
