|
Name |
Accession |
Description |
Interval |
E-value |
| PRK06354 |
PRK06354 |
pyruvate kinase; Provisional |
1-586 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 235784 [Multi-domain] Cd Length: 590 Bit Score: 871.94 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 1 MRKTKIVCTIGPASESEEMLEKLMKAGMNVARLNFSHGDHAEHKVRIDRIRSIAKKLDLNIGILLDTKGPEIRTHNMKDG 80
Cdd:PRK06354 7 MRRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASKKLGKTVGILQDLQGPKIRLGRFEDG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 81 KIVLEKGSEIIVSTSEVEGTPEKISVTYPDLINDLHDDSLILLDDGLIELRVKSLDAEKGEAVCNVLNTGELKNKKGVNL 160
Cdd:PRK06354 87 PIELKTGDEFILTSREVLGTQEKFSVTYDGLADEVPVGSRILLDDGLIELEVEEVDKADGELHCKVLVGGVLSNKKGVNF 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 161 PGVKTNLPGITDKDAEDIRFGIKEDIDFIAASFVRRPSDVLEIRKLLEEEKNEVISIIPKIENQEGIDNIESILQVSDGL 240
Cdd:PRK06354 167 PGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELIEEHNGKHIPIIAKIEKQEAIDNIDAILELCDGL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 241 MVARGDMGVEIPPERVPMVQKDLIRKCNKLGKPVITATQMLDSMQRNPRATRAEASDVANAIYDGTDAVMLSGETAAGDY 320
Cdd:PRK06354 247 MVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAILDGTDAVMLSNETAAGDY 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 321 PVEAVEAMRNIALAAEDAQDYGKILNDRTKLSMTsLVNAIGESVAHTALNLNVKAIVAATESGSTARIISKYRPKSDIIA 400
Cdd:PRK06354 327 PVEAVQTMATIAVRIEKDLPYRDILSKRPEFTTT-ITNAISQAVSHIALQLDAAAIVTLTKSGATARNVSKYRPKTPILA 405
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 401 VTPRDTTARQCTLVWGINPVVRSGRPSTDELLNKAVATAVDTGCVKNGDLIIITAGVPTGETGTTNLMKLHLVGDELATG 480
Cdd:PRK06354 406 VTPNESVARRLQLVWGVTPLLVLDAPSTDETFDAAINVAQESGLLKQGDLVVITAGTLVGESGSTDLMKVHVVGAVVAKG 485
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 481 QGIGRNSVVGHARLVKDAKEL----EGEdlsdsIIVTQSTDASFAPYISQAIGLVTEEGGLTSPSAIIGLEHHIPTIVGV 556
Cdd:PRK06354 486 QGIGRKSVSGKARVAKTAAEVakvnEGD-----ILVTPSTDADMIPAIEKAAAIITEEGGLTSHAAVVGLRLGIPVIVGV 560
|
570 580 590
....*....|....*....|....*....|
gi 2192624773 557 DDVLNVIEDGALITVDANQGKVFEGYANVL 586
Cdd:PRK06354 561 KNATSLIKDGQIITVDAARGVVYSGHASVL 590
|
|
| PykF |
COG0469 |
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ... |
1-473 |
0e+00 |
|
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 440237 [Multi-domain] Cd Length: 471 Bit Score: 780.37 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 1 MRKTKIVCTIGPASESEEMLEKLMKAGMNVARLNFSHGDHAEHKVRIDRIRSIAKKLDLNIGILLDTKGPEIRTHNMKDG 80
Cdd:COG0469 2 MRRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKEG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 81 KIVLEKGSEIIVSTSEVEGTPEKISVTYPDLINDLHDDSLILLDDGLIELRVKSldAEKGEAVCNVLNTGELKNKKGVNL 160
Cdd:COG0469 82 PVELKKGDTFTLTTDDVEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEE--VEGDEVVCEVVNGGVLSSRKGVNL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 161 PGVKTNLPGITDKDAEDIRFGIKEDIDFIAASFVRRPSDVLEIRKLLEEEKNEvISIIPKIENQEGIDNIESILQVSDGL 240
Cdd:COG0469 160 PGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGR-APIIAKIEKPEAVENLDEIIEASDGI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 241 MVARGDMGVEIPPERVPMVQKDLIRKCNKLGKPVITATQMLDSMQRNPRATRAEASDVANAIYDGTDAVMLSGETAAGDY 320
Cdd:COG0469 239 MVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKY 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 321 PVEAVEAMRNIALAAEDAQDYGKILNDRTKLSMTSLVNAIGESVAHTALNLNVKAIVAATESGSTARIISKYRPKSDIIA 400
Cdd:COG0469 319 PVEAVETMARIAEEAEKSLDYRRILDRLRDEPERTITDAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKVPILA 398
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2192624773 401 VTPRDTTARQCTLVWGINPVVRSGRPSTDELLNKAVATAVDTGCVKNGDLIIITAGVPTGETGTTNLMKLHLV 473
Cdd:COG0469 399 LTPNERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGVPGTTNTLKVHRV 471
|
|
| Pyruvate_Kinase |
cd00288 |
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ... |
1-473 |
0e+00 |
|
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.
Pssm-ID: 238178 [Multi-domain] Cd Length: 480 Bit Score: 645.91 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 1 MRKTKIVCTIGPASESEEMLEKLMKAGMNVARLNFSHGDHAEHKVRIDRIRSIAKKLDLNIGILLDTKGPEIRTHNMKDG 80
Cdd:cd00288 1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 81 -KIVLEKGSEIIVSTSE--VEGTPEKISVTYPDLINDLHDDSLILLDDGLIELRVKSLDAEKgEAVCNVLNTGELKNKKG 157
Cdd:cd00288 81 kDISLKAGDKFLVTTDPaaKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDK-TLVCEVLNGGVLGSRKG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 158 VNLPGVKTNLPGITDKDAEDIRFGIKEDIDFIAASFVRRPSDVLEIRKLLEEeKNEVISIIPKIENQEGIDNIESILQVS 237
Cdd:cd00288 160 VNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGE-KGKDIKIIAKIENQEGVNNFDEILEAS 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 238 DGLMVARGDMGVEIPPERVPMVQKDLIRKCNKLGKPVITATQMLDSMQRNPRATRAEASDVANAIYDGTDAVMLSGETAA 317
Cdd:cd00288 239 DGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAK 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 318 GDYPVEAVEAMRNIALAAEDAQDYGKILNDRTKLS--MTSLVNAIGESVAHTALNLNVKAIVAATESGSTARIISKYRPK 395
Cdd:cd00288 319 GKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTprPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRPN 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 396 SDIIAVTPRDTTARQCTLVWGINPVVRSGRP-----STDELLNKAVATAVDTGCVKNGDLIIITAGVPTGeTGTTNLMKL 470
Cdd:cd00288 399 APIIAVTRNEQTARQLHLYRGVYPVLFEEPKpgwqeDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVG-SGSTNTMRI 477
|
...
gi 2192624773 471 HLV 473
Cdd:cd00288 478 LTV 480
|
|
| pyruv_kin |
TIGR01064 |
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ... |
2-470 |
0e+00 |
|
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273424 [Multi-domain] Cd Length: 472 Bit Score: 626.62 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 2 RKTKIVCTIGPASESEEMLEKLMKAGMNVARLNFSHGDHAEHKVRIDRIRSIAKKLDLNIGILLDTKGPEIRTHNMKDGK 81
Cdd:TIGR01064 1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGGE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 82 IVLEKGSEIIVSTS--EVEGTPEKISVTYPDLINDLHDDSLILLDDGLIELRVKSLDAEKgeAVCNVLNTGELKNKKGVN 159
Cdd:TIGR01064 81 VKLKKGDKVIITTDdiKGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDK--VICEVLNGGTLKSKKGVN 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 160 LPGVKTNLPGITDKDAEDIRFGIKEDIDFIAASFVRRPSDVLEIRKLLEEEKNEVISIIPKIENQEGIDNIESILQVSDG 239
Cdd:TIGR01064 159 LPGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGAKDVKIIAKIENQEGVDNIDEIAEASDG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 240 LMVARGDMGVEIPPERVPMVQKDLIRKCNKLGKPVITATQMLDSMQRNPRATRAEASDVANAIYDGTDAVMLSGETAAGD 319
Cdd:TIGR01064 239 IMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGK 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 320 YPVEAVEAMRNIALAAEDAQDYGKILNDR--TKLSMTSLVNAIGESVAHTALNLNVKAIVAATESGSTARIISKYRPKSD 397
Cdd:TIGR01064 319 YPVEAVQMMAKIAKEAEKALAYLTNFNDRknSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNAP 398
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2192624773 398 IIAVTPRDTTARQCTLVWGINPVVRSGRPS-TDELLNKAVATAVDTGCVKNGDLIIITAGVPTGETGTTNLMKL 470
Cdd:TIGR01064 399 IIAVTPNERVARQLALYWGVFPFLVDEEPSdTDARVNKALELLKEKGIVKKGDLVVVIQGGPIGGEGGTNTIRV 472
|
|
| PK |
pfam00224 |
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ... |
1-345 |
2.75e-174 |
|
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.
Pssm-ID: 395168 [Multi-domain] Cd Length: 348 Bit Score: 497.28 E-value: 2.75e-174
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 1 MRKTKIVCTIGPASESEEMLEKLMKAGMNVARLNFSHGDHAEHKVRIDRIRSIAKKLDLNIGILLDTKGPEIRTHNMKDG 80
Cdd:pfam00224 1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 81 K--IVLEKGSEIIVSTSEV---EGTPEKISVTYPDLINDLHDDSLILLDDGLIELRVKSLDAEKGeAVCNVLNTGELKNK 155
Cdd:pfam00224 81 KkdIELKAGDEMIVSTDAKykgACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDKT-LVVEVLNGGVIGSR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 156 KGVNLPGVKTNLPGITDKDAEDIRFGIKEDIDFIAASFVRRPSDVLEIRKLLEEEkNEVISIIPKIENQEGIDNIESILQ 235
Cdd:pfam00224 160 KGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEA-GKNIQIIAKIENQEGVNNFDEILE 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 236 VSDGLMVARGDMGVEIPPERVPMVQKDLIRKCNKLGKPVITATQMLDSMQRNPRATRAEASDVANAIYDGTDAVMLSGET 315
Cdd:pfam00224 239 ATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGET 318
|
330 340 350
....*....|....*....|....*....|
gi 2192624773 316 AAGDYPVEAVEAMRNIALAAEDAQDYGKIL 345
Cdd:pfam00224 319 AKGNYPVEAVRMMHEICLEAEKALPHRNLF 348
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK06354 |
PRK06354 |
pyruvate kinase; Provisional |
1-586 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 235784 [Multi-domain] Cd Length: 590 Bit Score: 871.94 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 1 MRKTKIVCTIGPASESEEMLEKLMKAGMNVARLNFSHGDHAEHKVRIDRIRSIAKKLDLNIGILLDTKGPEIRTHNMKDG 80
Cdd:PRK06354 7 MRRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASKKLGKTVGILQDLQGPKIRLGRFEDG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 81 KIVLEKGSEIIVSTSEVEGTPEKISVTYPDLINDLHDDSLILLDDGLIELRVKSLDAEKGEAVCNVLNTGELKNKKGVNL 160
Cdd:PRK06354 87 PIELKTGDEFILTSREVLGTQEKFSVTYDGLADEVPVGSRILLDDGLIELEVEEVDKADGELHCKVLVGGVLSNKKGVNF 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 161 PGVKTNLPGITDKDAEDIRFGIKEDIDFIAASFVRRPSDVLEIRKLLEEEKNEVISIIPKIENQEGIDNIESILQVSDGL 240
Cdd:PRK06354 167 PGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELIEEHNGKHIPIIAKIEKQEAIDNIDAILELCDGL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 241 MVARGDMGVEIPPERVPMVQKDLIRKCNKLGKPVITATQMLDSMQRNPRATRAEASDVANAIYDGTDAVMLSGETAAGDY 320
Cdd:PRK06354 247 MVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAILDGTDAVMLSNETAAGDY 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 321 PVEAVEAMRNIALAAEDAQDYGKILNDRTKLSMTsLVNAIGESVAHTALNLNVKAIVAATESGSTARIISKYRPKSDIIA 400
Cdd:PRK06354 327 PVEAVQTMATIAVRIEKDLPYRDILSKRPEFTTT-ITNAISQAVSHIALQLDAAAIVTLTKSGATARNVSKYRPKTPILA 405
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 401 VTPRDTTARQCTLVWGINPVVRSGRPSTDELLNKAVATAVDTGCVKNGDLIIITAGVPTGETGTTNLMKLHLVGDELATG 480
Cdd:PRK06354 406 VTPNESVARRLQLVWGVTPLLVLDAPSTDETFDAAINVAQESGLLKQGDLVVITAGTLVGESGSTDLMKVHVVGAVVAKG 485
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 481 QGIGRNSVVGHARLVKDAKEL----EGEdlsdsIIVTQSTDASFAPYISQAIGLVTEEGGLTSPSAIIGLEHHIPTIVGV 556
Cdd:PRK06354 486 QGIGRKSVSGKARVAKTAAEVakvnEGD-----ILVTPSTDADMIPAIEKAAAIITEEGGLTSHAAVVGLRLGIPVIVGV 560
|
570 580 590
....*....|....*....|....*....|
gi 2192624773 557 DDVLNVIEDGALITVDANQGKVFEGYANVL 586
Cdd:PRK06354 561 KNATSLIKDGQIITVDAARGVVYSGHASVL 590
|
|
| PykF |
COG0469 |
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ... |
1-473 |
0e+00 |
|
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 440237 [Multi-domain] Cd Length: 471 Bit Score: 780.37 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 1 MRKTKIVCTIGPASESEEMLEKLMKAGMNVARLNFSHGDHAEHKVRIDRIRSIAKKLDLNIGILLDTKGPEIRTHNMKDG 80
Cdd:COG0469 2 MRRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKEG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 81 KIVLEKGSEIIVSTSEVEGTPEKISVTYPDLINDLHDDSLILLDDGLIELRVKSldAEKGEAVCNVLNTGELKNKKGVNL 160
Cdd:COG0469 82 PVELKKGDTFTLTTDDVEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEE--VEGDEVVCEVVNGGVLSSRKGVNL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 161 PGVKTNLPGITDKDAEDIRFGIKEDIDFIAASFVRRPSDVLEIRKLLEEEKNEvISIIPKIENQEGIDNIESILQVSDGL 240
Cdd:COG0469 160 PGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGR-APIIAKIEKPEAVENLDEIIEASDGI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 241 MVARGDMGVEIPPERVPMVQKDLIRKCNKLGKPVITATQMLDSMQRNPRATRAEASDVANAIYDGTDAVMLSGETAAGDY 320
Cdd:COG0469 239 MVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKY 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 321 PVEAVEAMRNIALAAEDAQDYGKILNDRTKLSMTSLVNAIGESVAHTALNLNVKAIVAATESGSTARIISKYRPKSDIIA 400
Cdd:COG0469 319 PVEAVETMARIAEEAEKSLDYRRILDRLRDEPERTITDAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKVPILA 398
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2192624773 401 VTPRDTTARQCTLVWGINPVVRSGRPSTDELLNKAVATAVDTGCVKNGDLIIITAGVPTGETGTTNLMKLHLV 473
Cdd:COG0469 399 LTPNERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGVPGTTNTLKVHRV 471
|
|
| Pyruvate_Kinase |
cd00288 |
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ... |
1-473 |
0e+00 |
|
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.
Pssm-ID: 238178 [Multi-domain] Cd Length: 480 Bit Score: 645.91 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 1 MRKTKIVCTIGPASESEEMLEKLMKAGMNVARLNFSHGDHAEHKVRIDRIRSIAKKLDLNIGILLDTKGPEIRTHNMKDG 80
Cdd:cd00288 1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 81 -KIVLEKGSEIIVSTSE--VEGTPEKISVTYPDLINDLHDDSLILLDDGLIELRVKSLDAEKgEAVCNVLNTGELKNKKG 157
Cdd:cd00288 81 kDISLKAGDKFLVTTDPaaKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDK-TLVCEVLNGGVLGSRKG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 158 VNLPGVKTNLPGITDKDAEDIRFGIKEDIDFIAASFVRRPSDVLEIRKLLEEeKNEVISIIPKIENQEGIDNIESILQVS 237
Cdd:cd00288 160 VNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGE-KGKDIKIIAKIENQEGVNNFDEILEAS 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 238 DGLMVARGDMGVEIPPERVPMVQKDLIRKCNKLGKPVITATQMLDSMQRNPRATRAEASDVANAIYDGTDAVMLSGETAA 317
Cdd:cd00288 239 DGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAK 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 318 GDYPVEAVEAMRNIALAAEDAQDYGKILNDRTKLS--MTSLVNAIGESVAHTALNLNVKAIVAATESGSTARIISKYRPK 395
Cdd:cd00288 319 GKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTprPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRPN 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 396 SDIIAVTPRDTTARQCTLVWGINPVVRSGRP-----STDELLNKAVATAVDTGCVKNGDLIIITAGVPTGeTGTTNLMKL 470
Cdd:cd00288 399 APIIAVTRNEQTARQLHLYRGVYPVLFEEPKpgwqeDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVG-SGSTNTMRI 477
|
...
gi 2192624773 471 HLV 473
Cdd:cd00288 478 LTV 480
|
|
| PRK05826 |
PRK05826 |
pyruvate kinase; Provisional |
1-463 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 235619 [Multi-domain] Cd Length: 465 Bit Score: 633.73 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 1 MRKTKIVCTIGPASESEEMLEKLMKAGMNVARLNFSHGDHAEHKVRIDRIRSIAKKLDLNIGILLDTKGPEIRTHNMKDG 80
Cdd:PRK05826 3 LRRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKLGRPVAILLDLKGPKIRVGKFKEG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 81 KIVLEKGSEIIVSTS-EVEGTPEKISVTYPDLINDLHDDSLILLDDGLIELRVKSLDAEkgEAVCNVLNTGELKNKKGVN 159
Cdd:PRK05826 83 KITLKTGDKFTLDTDqKEEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGD--EVETEVKNGGPLSNNKGIN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 160 LPGVKTNLPGITDKDAEDIRFGIKEDIDFIAASFVRRPSDVLEIRKLLEEEKNEVISIIPKIENQEGIDNIESILQVSDG 239
Cdd:PRK05826 161 IPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGCPHAKIIAKIERAEAVDNIDEIIEASDG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 240 LMVARGDMGVEIPPERVPMVQKDLIRKCNKLGKPVITATQMLDSMQRNPRATRAEASDVANAIYDGTDAVMLSGETAAGD 319
Cdd:PRK05826 241 IMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAAGK 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 320 YPVEAVEAMRNIALAAEDAQDYGKIlNDRTKLSMTSLVNAIGESVAHTALNLN-VKAIVAATESGSTARIISKYRPKSDI 398
Cdd:PRK05826 321 YPVEAVEAMARICKGAEKEFSINLS-KHRLDRQFDRIDEAIAMSAMYAANHLKgVKAIVALTESGRTARLISRFRPGAPI 399
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2192624773 399 IAVTPRDTTARQCTLVWGINPVVRSGRPSTDELLNKAVATAVDTGCVKNGDLIIITAGVPTGETG 463
Cdd:PRK05826 400 FAVTRDEKTQRRLALYRGVYPVLFDSAADTDDAAEEALRLLLEKGLVESGDLVVVTSGDPMGTAG 464
|
|
| pyruv_kin |
TIGR01064 |
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ... |
2-470 |
0e+00 |
|
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273424 [Multi-domain] Cd Length: 472 Bit Score: 626.62 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 2 RKTKIVCTIGPASESEEMLEKLMKAGMNVARLNFSHGDHAEHKVRIDRIRSIAKKLDLNIGILLDTKGPEIRTHNMKDGK 81
Cdd:TIGR01064 1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGGE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 82 IVLEKGSEIIVSTS--EVEGTPEKISVTYPDLINDLHDDSLILLDDGLIELRVKSLDAEKgeAVCNVLNTGELKNKKGVN 159
Cdd:TIGR01064 81 VKLKKGDKVIITTDdiKGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDK--VICEVLNGGTLKSKKGVN 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 160 LPGVKTNLPGITDKDAEDIRFGIKEDIDFIAASFVRRPSDVLEIRKLLEEEKNEVISIIPKIENQEGIDNIESILQVSDG 239
Cdd:TIGR01064 159 LPGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGAKDVKIIAKIENQEGVDNIDEIAEASDG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 240 LMVARGDMGVEIPPERVPMVQKDLIRKCNKLGKPVITATQMLDSMQRNPRATRAEASDVANAIYDGTDAVMLSGETAAGD 319
Cdd:TIGR01064 239 IMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGK 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 320 YPVEAVEAMRNIALAAEDAQDYGKILNDR--TKLSMTSLVNAIGESVAHTALNLNVKAIVAATESGSTARIISKYRPKSD 397
Cdd:TIGR01064 319 YPVEAVQMMAKIAKEAEKALAYLTNFNDRknSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNAP 398
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2192624773 398 IIAVTPRDTTARQCTLVWGINPVVRSGRPS-TDELLNKAVATAVDTGCVKNGDLIIITAGVPTGETGTTNLMKL 470
Cdd:TIGR01064 399 IIAVTPNERVARQLALYWGVFPFLVDEEPSdTDARVNKALELLKEKGIVKKGDLVVVIQGGPIGGEGGTNTIRV 472
|
|
| PRK09206 |
PRK09206 |
pyruvate kinase PykF; |
1-473 |
0e+00 |
|
pyruvate kinase PykF;
Pssm-ID: 181699 [Multi-domain] Cd Length: 470 Bit Score: 559.29 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 1 MRKTKIVCTIGPASESEEMLEKLMKAGMNVARLNFSHGDHAEHKVRIDRIRSIAKKLDLNIGILLDTKGPEIRTHNMKDG 80
Cdd:PRK09206 1 MKKTKIVCTIGPKTESEEMLTKLLDAGMNVMRLNFSHGDYAEHGQRIKNLRNVMSKTGKKAAILLDTKGPEIRTMKLEGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 81 KIV-LEKGSEIIVSTS-EVEGTPEKISVTYPDLINDLHDDSLILLDDGLIELRVKSLdaEKGEAVCNVLNTGELKNKKGV 158
Cdd:PRK09206 81 NDVsLKAGQTFTFTTDkSVVGNKERVAVTYEGFTADLSVGNTVLVDDGLIGMEVTAI--TGNEVICKVLNNGDLGENKGV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 159 NLPGVKTNLPGITDKDAEDIRFGIKEDIDFIAASFVRRPSDVLEIRKLLEEEKNEVISIIPKIENQEGIDNIESILQVSD 238
Cdd:PRK09206 159 NLPGVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAHGGENIQIISKIENQEGLNNFDEILEASD 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 239 GLMVARGDMGVEIPPERVPMVQKDLIRKCNKLGKPVITATQMLDSMQRNPRATRAEASDVANAIYDGTDAVMLSGETAAG 318
Cdd:PRK09206 239 GIMVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKG 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 319 DYPVEAVEAMRNIAlAAEDAQDYGKI--LNDRTKLSMTSlvnAIGESVAHTALNLNVKAIVAATESGSTARIISKYRPKS 396
Cdd:PRK09206 319 KYPLEAVSIMATIC-ERTDRVMNSRLesNNDNRKLRITE---AVCRGAVETAEKLDAPLIVVATQGGKSARSVRKYFPDA 394
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2192624773 397 DIIAVTPRDTTARQCTLVWGINPVVRSGRPSTDELLNKAVATAVDTGCVKNGDLIIITAG--VPtgeTGTTNLMKLHLV 473
Cdd:PRK09206 395 TILALTTNEKTARQLVLSKGVVPQLVKEIASTDDFYRLGKELALQSGLAQKGDVVVMVSGalVP---SGTTNTASVHVL 470
|
|
| PRK06247 |
PRK06247 |
pyruvate kinase; Provisional |
2-479 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 180487 [Multi-domain] Cd Length: 476 Bit Score: 524.49 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 2 RKTKIVCTIGPASESEEMLEKLMKAGMNVARLNFSHGDHAEHKVRIDRIRSIAKKLDLNIGILLDTKGPEIRTHNMKDGK 81
Cdd:PRK06247 5 RRVKILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIREVEDETGRPIGILADLQGPKLRLGRFADGK 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 82 IVLEKGSEIIVSTSEVEGTPEKISVTYPDLINDLHDDSLILLDDGLIELRVKSLDAEkgEAVCNVLNTGELKNKKGVNLP 161
Cdd:PRK06247 85 VQLANGQTFRLDVDDAPGDHDRVSLPHPEIAAALKPGDRLLVDDGKVRLVVEACDGD--DVVCRVVEGGPVSDRKGVSLP 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 162 GVKTNLPGITDKDAEDIRFGIKEDIDFIAASFVRRPSDVLEIRKLLEEEknevISIIPKIENQEGIDNIESILQVSDGLM 241
Cdd:PRK06247 163 GTVLSVSALTEKDRADLEFALELGVDWVALSFVQRPEDVEEVRKIIGGR----VPVMAKIEKPQAIDRLEAIVEASDAIM 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 242 VARGDMGVEIPPERVPMVQKDLIRKCNKLGKPVITATQMLDSMQRNPRATRAEASDVANAIYDGTDAVMLSGETAAGDYP 321
Cdd:PRK06247 239 VARGDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVMLSAETASGKYP 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 322 VEAVEAMRNIALAAEDAQDYGKILN-DRTKLSMTSlVNAIGESVAHTALNLNVKAIVAATESGSTARIISKYRPKSDIIA 400
Cdd:PRK06247 319 VEAVRTMARIIRQVERDPTYPPLIHaQRPQPEATK-RDAISYAARDIAERLDLAALVAYTSSGDTALRAARERPPLPILA 397
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2192624773 401 VTPRDTTARQCTLVWGINPVVRSGRPSTDELLNKAVATAVDTGCVKNGDLIIITAGVPTGETGTTNLMKLHLVGDELAT 479
Cdd:PRK06247 398 LTPNPETARRLALTWGVHCVVVDDARDTDDMVRRADRIALAEGFYKRGDRVVIVAGVPPGTPGSTNMLRIAYIGEDDVS 476
|
|
| PLN02461 |
PLN02461 |
Probable pyruvate kinase |
3-452 |
7.86e-175 |
|
Probable pyruvate kinase
Pssm-ID: 215255 [Multi-domain] Cd Length: 511 Bit Score: 504.90 E-value: 7.86e-175
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 3 KTKIVCTIGPASESEEMLEKLMKAGMNVARLNFSHGDHAEHKVRIDRIRSIAKKLDLNIGILLDTKGPEIRTHNMKDGK- 81
Cdd:PLN02461 22 KTKIVCTLGPASRSVPMLEKLLRAGMNVARFNFSHGSHEYHQETLDNLRQAMANTGILCAVMLDTKGPEIRTGFLKDGKp 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 82 IVLEKGSEIIVSTS-EVEGTPEKISVTYPDLINDLHDDSLILLDDGLIELRVKSLDAEKGEAVCNVLNTGELKNKKGVNL 160
Cdd:PLN02461 102 VQLKQGQEITITTDySIKGDENMIAMSYKKLAVDVKPGSVILCADGTITLTVLSCDVEAGTVRCRCENSAMLGERKNVNL 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 161 PGVKTNLPGITDKDAEDI-RFGIKEDIDFIAASFVRRPSDVLEIRKLL-EEEKNevISIIPKIENQEGIDNIESILQVSD 238
Cdd:PLN02461 182 PGVVVDLPTLTEKDKEDIlQWGVPNKIDFIALSFVRKGSDLVEVRKVLgEHAKS--ILLISKVENQEGLDNFDDILAESD 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 239 GLMVARGDMGVEIPPERVPMVQKDLIRKCNKLGKPVITATQMLDSMQRNPRATRAEASDVANAIYDGTDAVMLSGETAAG 318
Cdd:PLN02461 260 AFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVMLSGETAAG 339
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 319 DYPVEAVEAMRNIALAAEDAQDYG---KILNDRTKLSMTSLvNAIGESVAHTALNLNVKAIVAATESGSTARIISKYRPK 395
Cdd:PLN02461 340 AYPELAVKTMARICREAEASLDYGalfKEIMRSAPLPMSPL-ESLASSAVRTANKVKASLIVVLTRGGTTARLVAKYRPA 418
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2192624773 396 SDIIAV-TPRDTT------------ARQCTLVWGINPVVRSG------RPSTDELLNKAVATAVDTGCVKNGDLII 452
Cdd:PLN02461 419 VPILSVvVPEITTdsfdwscsdeapARHSLIYRGLIPVLAEGsakatdSESTEEILEAAIEHAKKKGLCKPGDSVV 494
|
|
| PK |
pfam00224 |
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ... |
1-345 |
2.75e-174 |
|
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.
Pssm-ID: 395168 [Multi-domain] Cd Length: 348 Bit Score: 497.28 E-value: 2.75e-174
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 1 MRKTKIVCTIGPASESEEMLEKLMKAGMNVARLNFSHGDHAEHKVRIDRIRSIAKKLDLNIGILLDTKGPEIRTHNMKDG 80
Cdd:pfam00224 1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 81 K--IVLEKGSEIIVSTSEV---EGTPEKISVTYPDLINDLHDDSLILLDDGLIELRVKSLDAEKGeAVCNVLNTGELKNK 155
Cdd:pfam00224 81 KkdIELKAGDEMIVSTDAKykgACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDKT-LVVEVLNGGVIGSR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 156 KGVNLPGVKTNLPGITDKDAEDIRFGIKEDIDFIAASFVRRPSDVLEIRKLLEEEkNEVISIIPKIENQEGIDNIESILQ 235
Cdd:pfam00224 160 KGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEA-GKNIQIIAKIENQEGVNNFDEILE 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 236 VSDGLMVARGDMGVEIPPERVPMVQKDLIRKCNKLGKPVITATQMLDSMQRNPRATRAEASDVANAIYDGTDAVMLSGET 315
Cdd:pfam00224 239 ATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGET 318
|
330 340 350
....*....|....*....|....*....|
gi 2192624773 316 AAGDYPVEAVEAMRNIALAAEDAQDYGKIL 345
Cdd:pfam00224 319 AKGNYPVEAVRMMHEICLEAEKALPHRNLF 348
|
|
| PTZ00066 |
PTZ00066 |
pyruvate kinase; Provisional |
2-470 |
3.66e-146 |
|
pyruvate kinase; Provisional
Pssm-ID: 173361 [Multi-domain] Cd Length: 513 Bit Score: 431.88 E-value: 3.66e-146
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 2 RKTKIVCTIGPASESEEMLEKLMKAGMNVARLNFSHGDHAEHKVRIDRIRSIAKKL-DLNIGILLDTKGPEIRTHNMKDG 80
Cdd:PTZ00066 38 KKTHIVCTMGPACKNVETLVKLIDAGMNICRFNFSHGDHESHKKTLNNVREAAKARpNANLGILLDTKGPEIRTGFLKNH 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 81 K-IVLEKGSEI-IVSTSEVEGTPEKISVTYPDLINDLHDDSLILLDDGliELRVKSLDAEKGEAVCNVLNTGELKNKKGV 158
Cdd:PTZ00066 118 KpITLKEGQTLkITTDYTFLGDETCISCSYKKLPQSVKVGNIILIADG--SLSCKVLEVHDDYIITKVLNNATIGERKNM 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 159 NLPGVKTNLPGITDKDAEDI-RFGIKEDIDFIAASFVRRPSDVLEIRKLLEEeKNEVISIIPKIENQEGIDNIESILQVS 237
Cdd:PTZ00066 196 NLPGVKVELPVIGEKDKNDIlNFAIPMGCDFIALSFVQSADDVRLCRQLLGE-RGRHIKIIPKIENIEGLINFDEILAES 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 238 DGLMVARGDMGVEIPPERVPMVQKDLIRKCNKLGKPVITATQMLDSMQRNPRATRAEASDVANAIYDGTDAVMLSGETAA 317
Cdd:PTZ00066 275 DGIMVARGDLGMEIPPEKVFLAQKMMISKCNVAGKPVITATQMLESMIKNPRPTRAESTDVANAVLDGTDCVMLSGETAN 354
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 318 GDYPVEAVEAMRNIALAAEDAQDYGKILNDRTKLSMT--SLVNAIGESVAHTALNLNVKAIVAATESGSTARIISKYRPK 395
Cdd:PTZ00066 355 GKFPVEAVNIMAKICFEAETCIDYRVLYHAIHLAVPTpvSVQEAVARSAVETAEDINAKLIIALTETGNTARLISKYRPS 434
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2192624773 396 SDIIAVTPRDTTARQCTLVWGINPVVRSGRPSTDELLNKAVATAVDTGCVKNGDLIIITAGVPTGETGTTNLMKL 470
Cdd:PTZ00066 435 CTILALSASPSVVKSLSVARGVTTYVVNSFQGTDVVIRNAIALAKERGLVESGDSAIAVHGVKEEVAGSSNLMKV 509
|
|
| PykA2 |
COG3848 |
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms]; |
266-586 |
2.00e-139 |
|
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];
Pssm-ID: 443058 Cd Length: 321 Bit Score: 407.36 E-value: 2.00e-139
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 266 KCNKLGKPVITATQMLDSMQRNPRATRAEASDVANAIYDGTDAVMLSGETAAGDYPVEAVEAMRNIALAAEDAQDYGKIL 345
Cdd:COG3848 1 KCNAAGKPVITATQMLDSMMRNPRPTRAEAADVANAIFDGTDAIMLSGETAAGKYPVEAVVTMVRIAERAEEDLEYREQR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 346 NDRTKLSMTSLVNAIGESVAHTALNLNVKAIVAATESGSTARIISKYRPKSDIIAVTPRDTTARQCTLVWGINPVVRSGR 425
Cdd:COG3848 81 VPRAKESSTTITDAISHAVATTAADLGAAAIITATESGATARMVSKYRPKAPIIAVTPSERVARQLSLVWGVYPLLVEES 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 426 PSTDELLNKAVATAVDTGCVKNGDLIIITAGVPTGETGTTNLMKLHLVGDELATGQGIGRNSVVGHARLVKDAKELEGED 505
Cdd:COG3848 161 ASTDEMFAVAVALALEAGLVKDGDLVVITAGVPVGVSGTTNLLKVHVVGDVLAKGQGIGRGSVTGKAVVARSAEEALEKF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 506 LSDSIIVTQSTDASFAPYISQAIGLVTEEGGLTSPSAIIGLEHHIPTIVGVDDVLNVIEDGALITVDANQGKVFEGYANV 585
Cdd:COG3848 241 EEGDILVVPSTDAEFVPAIEKAAGIITEEGGLTSHAAIVGLELGIPVIVGAEGATEILKDGQVVTVDAERGVVYRGAVNV 320
|
.
gi 2192624773 586 L 586
Cdd:COG3848 321 L 321
|
|
| PTZ00300 |
PTZ00300 |
pyruvate kinase; Provisional |
28-453 |
1.62e-127 |
|
pyruvate kinase; Provisional
Pssm-ID: 140321 [Multi-domain] Cd Length: 454 Bit Score: 382.09 E-value: 1.62e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 28 MNVARLNFSHGDHAEHKVRIDRIRSIAKKLDLNIGILLDTKGPEIRTHNMKDGKIVLEKGSEIIVSTS---EVEGTPEKI 104
Cdd:PTZ00300 1 MSVARMNFSHGSHEYHQTTINNVRQAAAELGVNIAIALDTKGPEIRTGLFVGGEAVMERGATCYVTTDpafADKGTKDKF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 105 SVTYPDLINDLHDDSLILLDDGLIELRVKSLDAEKgEAVCNVLNTGELKNKKGVNLPGVKTNLPGITDKDAEDIRFGIKE 184
Cdd:PTZ00300 81 YIDYQNLSKVVRPGGYIYIDDGILILHVQSHEDEQ-TLKCTVTNAHTISDRRGVNLPGCDVDLPAVSAKDCADLQFGVEQ 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 185 DIDFIAASFVRRPSDVLEIRKLLEEEKNEVIsIIPKIENQEGIDNIESILQVSDGLMVARGDMGVEIPPERVPMVQKDLI 264
Cdd:PTZ00300 160 GVDMIFASFIRSAEQVGEVRKALGAKGGDIM-IICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVVVAQKILI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 265 RKCNKLGKPVITATQMLDSMQRNPRATRAEASDVANAIYDGTDAVMLSGETAAGDYPVEAVEAMRNIALAAEDAQDYGKI 344
Cdd:PTZ00300 239 SKCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICLEAQSAVNEYVF 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 345 LNDRTKLSM--TSLVNAIGESVAHTALNLNVKAIVAATESGSTARIISKYRPKSDIIAVTPRDTTARQCTLVWGINPVV- 421
Cdd:PTZ00300 319 FNSIKKLQPipMSAEEAVCSSAVNSVYETKAKALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQGVESVFf 398
|
410 420 430
....*....|....*....|....*....|....*.
gi 2192624773 422 RSGRPSTDELLNKAVATAVD----TGCVKNGDLIII 453
Cdd:PTZ00300 399 DAERLGHDEGKEQRVAMGVGfaksKGYVQSGDLMVV 434
|
|
| PLN02623 |
PLN02623 |
pyruvate kinase |
2-449 |
7.90e-122 |
|
pyruvate kinase
Pssm-ID: 215334 [Multi-domain] Cd Length: 581 Bit Score: 371.57 E-value: 7.90e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 2 RKTKIVCTIGPASESEEMLEKLMKAGMNVARLNFSHGDHAEHKVRIDRIRSIAKKLDLN-IGILLDTKGPEIRTHNMKDg 80
Cdd:PLN02623 110 RKTKIVCTIGPSTNTREMIWKLAEAGMNVARLNMSHGDHASHQKVIDLVKEYNAQSKDNvIAIMLDTKGPEVRSGDLPQ- 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 81 KIVLEKGSEIIVSTSEVEGTPEKISVTYPDLINDLHDDSLILLDDGLIELRVKSLDAEkgEAVCNVLNTGELKNKKGVNL 160
Cdd:PLN02623 189 PIMLEEGQEFTFTIKRGVSTEDCVSVNYDDFVNDVEVGDMLLVDGGMMSLAVKSKTSD--SVKCEVVDGGELKSRRHLNV 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 161 PGVKTNLPGITDKDAEDIRFGIKEDIDFIAASFVRRPSDVLEIRKLLEEeKNEVISIIPKIENQEGIDNIESILQVSDGL 240
Cdd:PLN02623 267 RGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKDYLKS-CNADIHVIVKIESADSIPNLHSIITASDGA 345
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 241 MVARGDMGVEIPPERVPMVQKDLIRKCNKLGKPVITATQMLDSMQRNPRATRAEASDVANAIYDGTDAVMLSGETAAGDY 320
Cdd:PLN02623 346 MVARGDLGAELPIEEVPLLQEEIIRRCRSMGKPVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAHGKF 425
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 321 PVEAVEAMRNIALAAEDAQDYGKILNDRTKLSMtslvNAIGESVA-HTALNLNV--KAIVAATESGSTARIISKYRPKSD 397
Cdd:PLN02623 426 PLKAVKVMHTVALRTEATLPEGTTPPNLGQAFK----NHMSEMFAfHATMMANTlgTSIIVFTRTGFMAILLSHYRPSGT 501
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 2192624773 398 IIAVTPRDTTARQCTLVWGINPVVRSGRPSTDELLNKAVATAVDTGCVKNGD 449
Cdd:PLN02623 502 IFAFTNEKRIQQRLALYQGVCPIYMQFSDDAEETFARALSLLLNKGMVKEGE 553
|
|
| PRK06739 |
PRK06739 |
pyruvate kinase; Validated |
7-342 |
5.29e-104 |
|
pyruvate kinase; Validated
Pssm-ID: 180676 [Multi-domain] Cd Length: 352 Bit Score: 318.04 E-value: 5.29e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 7 VCTIGPASESEEMLEKLMKAGMNVARLNFSHGDHAEHKVRIDRIRSiakkLDLNIGILLDTKGPEIRTHNMKDGKIVLEK 86
Cdd:PRK06739 6 ICTIGPASNNKETLAQLINNGMKIVRLNLSHGTHESHKDIIRLVKS----LDDSIKILGDVQGPKIRLGEIKGEQITLQA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 87 GSEIIVSTSEVEGTPEKISVTYPDLINDLHDDSLILLDDGLIELRVKSLDAEKGEAvcNVLNTGELKNKKGVNLPGVKTN 166
Cdd:PRK06739 82 GDSFILHTQPVTGSSTEASVDYEGIANDVKVGSRILMNDGEVELIVEKVSTDKIET--KVKTGGNISSHKGVNLPGAIVR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 167 LPGITDKDAEDIRFGIKEDIDFIAASFVRRPSDVLEIRKLLEEEKNEVISIIPKIENQEGIDNIESILQVSDGLMVARGD 246
Cdd:PRK06739 160 LPAITEKDKKDIQFLLEEDVDFIACSFVRKPSHIKEIRDFIQQYKETSPNLIAKIETMEAIENFQDICKEADGIMIARGD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 247 MGVEIPPERVPMVQKDLIRKCNKLGKPVITATQMLDSMQRNPRATRAEASDVANAIYDGTDAVMLSGETAAGDYPVEAVE 326
Cdd:PRK06739 240 LGVELPYQFIPLLQKMMIQECNRTNTYVITATQMLQSMVDHSIPTRAEVTDVFQAVLDGTNAVMLSAESASGEHPIESVS 319
|
330
....*....|....*.
gi 2192624773 327 AMRNIALAAEDAQDYG 342
Cdd:PRK06739 320 TLRLVSEFAEHVKKDG 335
|
|
| PLN02765 |
PLN02765 |
pyruvate kinase |
4-453 |
1.33e-99 |
|
pyruvate kinase
Pssm-ID: 215409 [Multi-domain] Cd Length: 526 Bit Score: 312.37 E-value: 1.33e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 4 TKIVCTIGPASESEEMLEKLMKAGMNVARLNFSHGDHAEHKVRIDRIRSIAKKLDLNIGILLDTKGPEIRTHNMKDGKIV 83
Cdd:PLN02765 30 TKIVGTLGPKSRSVEVIEACLKAGMSVARFDFSWGDAEYHQETLENLKIAVKNTKKLCAVMLDTVGPELQVINKTEKPIS 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 84 LEKGSEIIVSTSE-VEGTPEKISVTYPDLINDLHDDSLILLDDGL--------IELRVKSLDAEkgEAVCNVLNTGELKn 154
Cdd:PLN02765 110 LKAGNTVTLTPDQsKEASSEVLPINFPGLAKAVKPGDTIFVGQYLftgsettsVWLEVDEVKGD--DVVCTVKNSATLA- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 155 kkGVNLP----GVKTNLPGITDKDAEDIR-FGIKEDIDFIAASFVRRPSDVLEIRKLLEEEKNEVISIIPKIENQEGIDN 229
Cdd:PLN02765 187 --GSLFTlhvsQVRIDLPTLSEKDKEVIStWGVPNKIDFLSLSYTRHAEDVREAREFLSSLGLSQTQIFAKIENVEGLTH 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 230 IESILQVSDGLMVARGDMGVEIPPERVPMVQKDLIRKCNKLGKPVITaTQMLDSMQRNPRATRAEASDVANAIYDGTDAV 309
Cdd:PLN02765 265 FDEILQEADGIILSRGNLGIDLPPEKVFLFQKAALYKCNMAGKPAVV-TRVVDSMTDNLRPTRAEATDVANAVLDGADAI 343
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 310 MLSGETAAGDYPVEAVEAMRNIALAAE---DAQDYGKILNDRTKLSMTSLvNAIGESVAHTALNLNVKAIVAATESGSTA 386
Cdd:PLN02765 344 LLGAETLRGLYPVETISTVGRICAEAEkvfNQDLYFKKTVKYVGEPMSHL-ESIASSAVRAAIKVKASVIIVFTSSGRAA 422
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 387 RIISKYRPKSDIIAVT-PRDTT------------ARQCTLVWGINPVVRSGRPSTDE-------LLNKAVATAVDTGCVK 446
Cdd:PLN02765 423 RLIAKYRPTMPVLSVViPRLKTnqlkwsftgafqARQCLIVRGLFPMLADPRHSAEStsatnesVLKVALDHGKAAGVIK 502
|
....*..
gi 2192624773 447 NGDLIII 453
Cdd:PLN02765 503 SHDRVVV 509
|
|
| PLN02762 |
PLN02762 |
pyruvate kinase complex alpha subunit |
1-453 |
3.34e-91 |
|
pyruvate kinase complex alpha subunit
Pssm-ID: 215407 [Multi-domain] Cd Length: 509 Bit Score: 290.11 E-value: 3.34e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 1 MRKTKIVCTIGPASESEEMLEKLMKAGMNVARLNFSHGDHAEHKVRIDRIRSIAKKLDLNIGILLDTKGPEIrthNMKD- 79
Cdd:PLN02762 24 TRRTKLVCTIGPACCGFEQLEALAMGGMNVARLNMCHGTREWHRDVIRRVRRLNEEKGFAVAVMMDTEGSEI---HMGDl 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 80 ---GKIVLEKGSEIIVSTSEVEGT-PEK-ISVTYPDLINDLHDDSLILLDDGLIELRVksldAEK-GEAV-CNVLNTGEL 152
Cdd:PLN02762 101 ggaSSAKAEDGEEWTFTVRKFDGSrPEFtIQVNYDGFAEDVKVGDELVVDGGMVRFEV----IEKiGPDVkCKCTDPGLL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 153 knkkgvnLPGVKTN--------------LPGITDKDAEDIRFGIKEDIDFIAASFVRRPSDVLEIRKLLE-EEKNEVISI 217
Cdd:PLN02762 177 -------LPRANLTfwrdgslvrernamLPTISSKDWLDIDFGISEGVDFIAVSFVKSAEVIKHLKSYIAaRSRDSDIGV 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 218 IPKIENQEGIDNIESILQVSDGLMVARGDMGVEIPPERVPMVQKDLIRKCNKLGKPVITATQMLDSMQRNPRATRAEASD 297
Cdd:PLN02762 250 IAKIESLDSLKNLEEIIRASDGAMVARGDLGAQIPLEQVPSVQEKIVRLCRQLNKPVIVASQLLESMIEYPTPTRAEVAD 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 298 VANAIYDGTDAVMLSGETAAGDYPVEAVEAMRNIALAAE------------DAQDYGKILNDRTKlsmtslvNAIGESVA 365
Cdd:PLN02762 330 VSEAVRQRADALMLSGESAMGLYPEKALSVLRSVSLRMElwsreekrhealELPQLSSSLSDRIS-------EEICNSAA 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 366 HTALNLNVKAIVAATESGSTARIISKYRPKSDIIAVTPRDTTARQCTLVWGINPVVRSGRPSTDELLNKAVATAVDTGCV 445
Cdd:PLN02762 403 KMANNLGVDAIFVYTKHGHMASLLSRNRPDCPIFAFTDTTSVRRRLNLQWGLIPFRLDFSDDMESNLNKTFSLLKARGMI 482
|
....*...
gi 2192624773 446 KNGDLIII 453
Cdd:PLN02762 483 KSGDLVIA 490
|
|
| PK_C |
pfam02887 |
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ... |
358-471 |
1.78e-47 |
|
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.
Pssm-ID: 460738 [Multi-domain] Cd Length: 114 Bit Score: 161.49 E-value: 1.78e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 358 NAIGESVAHTALNLNVKAIVAATESGSTARIISKYRPKSDIIAVTPRDTTARQCTLVWGINPVVRSGRPSTDELLNKAVA 437
Cdd:pfam02887 1 EAIAHAAVEAAEELGAKAIVVLTESGYTARLISRYRPGVPIIAVTPNELTARQLALYWGVYPVLFDEAETTDEMLRRAVK 80
|
90 100 110
....*....|....*....|....*....|....
gi 2192624773 438 TAVDTGCVKNGDLIIITAGVPTGETGTTNLMKLH 471
Cdd:pfam02887 81 VAKEAGLVKKGDLVVITAGVPFGVSGTTNTLKVI 114
|
|
| PRK08187 |
PRK08187 |
pyruvate kinase; Validated |
2-331 |
1.63e-44 |
|
pyruvate kinase; Validated
Pssm-ID: 236178 Cd Length: 493 Bit Score: 165.19 E-value: 1.63e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 2 RKTKIVCTI-GPASESEEMLEKLMKAGMNVARLNFSHGDHAEHKVRIDRIRSIAKKLDLNIGILLDTKGPEIRTHN--MK 78
Cdd:PRK08187 133 RRTRIMVTLpSEAADDPDFVLRLAERGMDCARINCAHDDPAAWQAMIGHLRQAERATGRRCKILMDLAGPKIRTGAvaGP 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 79 DGKIVLEKGSEI-IVSTSEVEGTPE---KISVTYPDLINDLHDDSLILLDDGLIELRVKSLDAekGEAVCNVLNTGE--- 151
Cdd:PRK08187 213 LGKTRLYTGDRLaLVAQGPPRRIDEehfQVTCTLPEILARLAVGARVWIDDGKLGARVERVGP--GGALLEVTHARPkgl 290
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 152 -LKNKKGVNLPGVKTNLPGITDKDAEDIRFgIKEDIDFIAASFVRRPSDVleirKLLEEEKNE-------VISIIPKIEN 223
Cdd:PRK08187 291 kLKPEKGLNFPDTALDLPALTEKDRADLDF-VARHADLVGYSFVQSPGDV----EALQAALAArrpddwrKLGLVLKIET 365
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 224 QEGIDNI-ESILQVSD----GLMVARGDMGVEIPPERVPMVQKDLIRKCNKLGKPVITATQMLDSMQRNPRATRAEASDV 298
Cdd:PRK08187 366 PRAVANLpELIVQAAGrqpfGVMIARGDLAVEIGFERLAEMQEEILWLCEAAHVPVIWATQVLEGLVKKGLPSRAEMTDA 445
|
330 340 350
....*....|....*....|....*....|...
gi 2192624773 299 ANAiyDGTDAVMLSgetaAGDYPVEAVEAMRNI 331
Cdd:PRK08187 446 AMA--ARAECVMLN----KGPYLVEAVTFLDDL 472
|
|
| PRK14725 |
PRK14725 |
pyruvate kinase; Provisional |
80-331 |
6.75e-41 |
|
pyruvate kinase; Provisional
Pssm-ID: 237804 Cd Length: 608 Bit Score: 156.65 E-value: 6.75e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 80 GKIVLEKGSEIIVSTSEVEGTPE-------KISVTYPDLINDLHDDSLILLDDGLIELRVKSLDAEkgEAVCNVLNTGE- 151
Cdd:PRK14725 331 QKLRLKVGDRLVLTRDDAPGDPAqgdappaRISCTLPEAFRAARVGERVWFDDGKIGAVVVKVEAD--EVELRITHARPg 408
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 152 ---LKNKKGVNLPGVKTNLPGITDKDAEDIRFgIKEDIDFIAASFVRRPSDVLEIRKLLEEEKNEVISIIPKIENQEGID 228
Cdd:PRK14725 409 gskLKAGKGINLPDSHLPLPALTDKDLEDLAF-VAKHADIVALSFVRSPEDVRLLLDALEKLGADDLGVVLKIETRRAFE 487
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 229 NIESIL-----QVSDGLMVARGDMGVEIPPERVPMVQKDLIRKCNKLGKPVITATQMLDSMQRNPRATRAEASDVANAIY 303
Cdd:PRK14725 488 NLPRILleamrHPRFGVMIARGDLAVEVGFERLAEVQEEILWLCEAAHVPVIWATQVLESLAKKGLPSRAEITDAAMALR 567
|
250 260
....*....|....*....|....*...
gi 2192624773 304 dgTDAVMLSgetaAGDYPVEAVEAMRNI 331
Cdd:PRK14725 568 --AECVMLN----KGPHIVEAVRVLDDI 589
|
|
| PEP-utilizers |
pfam00391 |
PEP-utilizing enzyme, mobile domain; This domain is a "swivelling" beta/beta/alpha domain ... |
508-576 |
7.29e-18 |
|
PEP-utilizing enzyme, mobile domain; This domain is a "swivelling" beta/beta/alpha domain which is thought to be mobile in all proteins known to contain it.
Pssm-ID: 459796 [Multi-domain] Cd Length: 73 Bit Score: 78.22 E-value: 7.29e-18
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2192624773 508 DSIIVTQSTDASFAPYISQAIGLVTEEGGLTSPSAIIGLEHHIPTIVGVDDVLNVIEDGALITVDANQG 576
Cdd:pfam00391 5 GVILVAPDTTPSDTAGLDKAAGIVTERGGMTSHAAIVARELGIPAVVGVGDATILLKEGDLVTVDGSTG 73
|
|
| PpsA |
COG0574 |
Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and ... |
474-578 |
7.62e-16 |
|
Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Phosphoenolpyruvate synthase/pyruvate phosphate dikinase is part of the Pathway/BioSystem: Gluconeogenesis
Pssm-ID: 440339 [Multi-domain] Cd Length: 455 Bit Score: 80.26 E-value: 7.62e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 474 GDELATGQGIGRNSVVGHARLVKDAKEL----EGEdlsdsIIVTQSTDASFAPYISQAIGLVTEEGGLTSPSAIIGLEHH 549
Cdd:COG0574 351 GEVLAKGLPASPGAASGKVVFIADEAELarfqEGV-----ILVRDETDPDDVPGMKAAAGIVTERGGMTSHAAIVARELG 425
|
90 100
....*....|....*....|....*....
gi 2192624773 550 IPTIVGVDDVLNVIEDGALITVDANQGKV 578
Cdd:COG0574 426 IPAVVGCGDATRVLKDGDEITVDGTTGEV 454
|
|
| PRK06241 |
PRK06241 |
phosphoenolpyruvate synthase; Validated |
481-578 |
1.50e-14 |
|
phosphoenolpyruvate synthase; Validated
Pssm-ID: 235751 [Multi-domain] Cd Length: 871 Bit Score: 76.85 E-value: 1.50e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 481 QGIGRNS-VV-GHARLVKDAKELEGEDlsDSIIVTQSTDASFAPYISQAIGLVTEEGGLTSPSAIIGLEHHIPTIVGVDD 558
Cdd:PRK06241 769 IGLPVSSgVVeGRARVILNPEDADLEK--GDILVTAFTDPGWTPLFVSIKGLVTEVGGLMTHGAVIAREYGIPAVVGVEN 846
|
90 100
....*....|....*....|
gi 2192624773 559 VLNVIEDGALITVDANQGKV 578
Cdd:PRK06241 847 ATKLIKDGQRIRVDGTEGYV 866
|
|
| PRK06464 |
PRK06464 |
phosphoenolpyruvate synthase; Validated |
474-581 |
2.22e-14 |
|
phosphoenolpyruvate synthase; Validated
Pssm-ID: 235809 [Multi-domain] Cd Length: 795 Bit Score: 76.32 E-value: 2.22e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 474 GDELATGQGIGRNSVVGHARLVKDAKEL----EGEdlsdsIIVTQSTDASFAPYISQAIGLVTEEGGLTSPSAIIGLEHH 549
Cdd:PRK06464 353 GKVLVEGRAIGPGIGSGKVRVILDISEMdkvqPGD-----VLVTDMTDPDWEPVMKRASAIVTNRGGRTCHAAIIARELG 427
|
90 100 110
....*....|....*....|....*....|....*
gi 2192624773 550 IPTIVGVDDVLNVIEDGALITV---DANQGKVFEG 581
Cdd:PRK06464 428 IPAVVGTGNATEVLKDGQEVTVscaEGDTGYVYEG 462
|
|
| PRK08296 |
PRK08296 |
hypothetical protein; Provisional |
488-578 |
5.84e-11 |
|
hypothetical protein; Provisional
Pssm-ID: 181362 Cd Length: 603 Bit Score: 65.06 E-value: 5.84e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 488 VVGHARLVKDAKEL----EGEdlsdsIIVTQSTDASFAPYISQAIGLVTEEGGLTSPSAIIGLEHHIPTIVGVDDVLNVI 563
Cdd:PRK08296 510 VEGPARVIRSADELsevqEGE-----ILVCPVTSPSWAPIFAKIKATVTDIGGVMSHAAIVCREYGLPAVVGTGNATKRI 584
|
90
....*....|....*
gi 2192624773 564 EDGALITVDANQGKV 578
Cdd:PRK08296 585 KTGQRLRVDGTKGVV 599
|
|
| PRK05878 |
PRK05878 |
pyruvate phosphate dikinase; Provisional |
471-581 |
4.52e-08 |
|
pyruvate phosphate dikinase; Provisional
Pssm-ID: 235635 [Multi-domain] Cd Length: 530 Bit Score: 55.91 E-value: 4.52e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 471 HLVGDELATG----QGIGRNSVVGHARLVKDAKELeGEDLsdsIIVTQSTDASFAPYISQAIGLVTEEGGLTSPSAIIGL 546
Cdd:PRK05878 344 RLAAPLLAKGlpacPGVVSGTAYTDVDEALDAADR-GEPV---ILVRDHTRPDDVHGMLAAQGIVTEVGGATSHAAVVSR 419
|
90 100 110
....*....|....*....|....*....|....*
gi 2192624773 547 EHHIPTIVGVDDVLNVIEDGALITVDANQGKVFEG 581
Cdd:PRK05878 420 ELGRVAVVGCGAGVAAALAGKEITVDGYEGEVRQG 454
|
|
| PRK05865 |
PRK05865 |
sugar epimerase family protein; |
472-578 |
1.46e-05 |
|
sugar epimerase family protein;
Pssm-ID: 235630 [Multi-domain] Cd Length: 854 Bit Score: 48.12 E-value: 1.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192624773 472 LVGDELATGQGIGRNSVVGHARLVKDAK--ELE-GEdlsdsIIVTQSTDASFAPYISQAIGLVTEEGGLTSPSAIIGLEH 548
Cdd:PRK05865 730 LAAGDTLRGVGVCGGRVRGRVRIVRPETidDLQpGE-----ILVAEVTDVGYTAAFCYAAAVVTELGGPMSHAAVVAREF 804
|
90 100 110
....*....|....*....|....*....|
gi 2192624773 549 HIPTIVGVDDVLNVIEDGALITVDANQGKV 578
Cdd:PRK05865 805 GFPCVVDAQGATRFLPPGALVEVDGATGEI 834
|
|
| |
