|
Name |
Accession |
Description |
Interval |
E-value |
| TrpE |
COG0147 |
Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism, ... |
12-456 |
5.51e-166 |
|
Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Anthranilate/para-aminobenzoate synthases component I is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis
Pssm-ID: 439917 [Multi-domain] Cd Length: 416 Bit Score: 473.82 E-value: 5.51e-166
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 12 RKPHYVTLAADIDFFGLFKKIEKRfDNCFMLESLGEESHISRHSIIGFDPEQILWATEGELHVQGRDGAvnSYASDNPYY 91
Cdd:COG0147 2 RIPVYRELLALETPVSLFLKLADG-PYAFLLESAEGGEKWGRYSFIGADPLATLTVRGGRVTIEGGGEV--EPSEGDPLD 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 92 LLREIVPQNIISRK-----YAGGLTGYIGYDCMNYFEPSLKLQHSDM-FDVFRFGVFKDGLILDKMTGEViyfhyddsrl 165
Cdd:COG0147 79 ALRALLARFRLPPLpglppFTGGLVGYFGYDLVRYFERLPDLAPDDLgLPDAALGLYDRLLVFDHLKGTR---------- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 166 etieqilaepavSNgplqvtpmgetMTQAEHAAAVMKVKQDIIDGKVFQCEVGFKKRFRLEGDTINLYEQLREVNPSPQM 245
Cdd:COG0147 149 ------------SN-----------FTREEYLAAVERAKEYIRAGDIFQVVLSQRFSAPFEGDPLALYRALRRINPSPYM 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 246 YYVKFGEQKLIGASPELLFRLRQGEMETFPLAGTTKRGANEVEDTQFARTLLNDPKEIAEHNMIVDLHRNDIGRVARFGT 325
Cdd:COG0147 206 FYLRFGDFAIVGSSPERLVRVEDGRVETRPIAGTRPRGATPEEDAALAEELLADEKERAEHLMLVDLARNDLGRVCEPGS 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 326 VKVRSLMDIKRFSHVQHISSEIVGIISEDHDMFSALASNFPAGTLTGAPKIEAMKIIDDLESDGRGPYGGAVGHFSFNGD 405
Cdd:COG0147 286 VKVPELMVVERYSHVMHLVSTVTGRLRPGLDALDALRATFPAGTLTGAPKIRAMEIIDELEPTRRGVYGGAVGYLSFDGN 365
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 2197122856 406 CTFAIPIRTVFANGENAYVQTCGGNVYDSNPEDEYEEIRRKFAGTKKVLDQ 456
Cdd:COG0147 366 MDLAIAIRTAVVKDGRAYVQAGAGIVADSDPEAEYQETLNKARALLRALEL 416
|
|
| TrpE-arch |
TIGR01820 |
anthranilate synthase component I, archaeal clade; This model represents an archaeal clade of ... |
26-455 |
2.32e-133 |
|
anthranilate synthase component I, archaeal clade; This model represents an archaeal clade of anthranilate synthase component I enzymes. This enzyme is responsible for the first step of tryptophan biosynthesis from chorismate. The Sulfolobus enzyme has been reported to be part of a gene cluster for Trp biosynthesis [Amino acid biosynthesis, Aromatic amino acid family]
Pssm-ID: 273819 [Multi-domain] Cd Length: 435 Bit Score: 391.73 E-value: 2.32e-133
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 26 FGLFKKIEKRFDNCFMLESLGEESHISRHSIIGFDPEQILWATEGELHVQGRDGAVNSYAS-DNPYYLLREIVPQNIiSR 104
Cdd:TIGR01820 2 LELYKAIRADGDYAFLLESAEKPSKKARYSFIGWDPEFVVRINGKGKSVEGIPEDGDVVDKlRNAFPKLKGINIPGE-DR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 105 KYAGGLTGYIGYDCM-NYFEPSLKLQHSDMFDVF-RFGVFKDGLILDKMTGEVIYFHYDD--SRLETIeQILAEPAVSNG 180
Cdd:TIGR01820 81 RFKGGLVGYIAYDAVrDYWEGIVDLKRKAEDWPPaEFFIYPNTIVYDHLEGKVYYVSTPEpeAELERI-VERAKRATDPG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 181 PLQVTPMGETM-TQAEHAAAVMKVKQDIIDGKVFQCEVGFKKRFRLEGDTINLYEQLREVNPSPQMYYVKFGEQKLIGAS 259
Cdd:TIGR01820 160 EAGVSFEGESLsDREEFEEAVEEAKEYIFAGDIFQVVLSREYEYRLDGDPFELYYNLREINPSPYMFLLKFGDRYLVGSS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 260 PELLFRLRQGEMETFPLAGTTKRGANEVEDTQFARTLLNDPKEIAEHNMIVDLHRNDIGRVARFGTVKVRSLMDIKRFSH 339
Cdd:TIGR01820 240 PETLVRVEGRTVETNPIAGTRPRGATPEEDERLAKELLSDEKERAEHVMLVDLARNDVRKVSEPGSVKVPEFMYVEKYSH 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 340 VQHISSEIVGIISEDHDMFSALASNFPAGTLTGAPKIEAMKIIDDLESDGRGPYGGAVGHFSFNGDCTFAIPIRTVFANG 419
Cdd:TIGR01820 320 VQHIESTVIGTLKKDYDAFDALRATFPAGTLSGAPKIRAMEIIDELEKEPRGVYGGGVGYFSWNGDADFAIAIRTAEIDK 399
|
410 420 430
....*....|....*....|....*....|....*.
gi 2197122856 420 ENAYVQTCGGNVYDSNPEDEYEEIRRKFAGTKKVLD 455
Cdd:TIGR01820 400 DKLRIQAGAGIVADSIPEREFEETENKMKAVLKAIG 435
|
|
| trpE_most |
TIGR00564 |
anthranilate synthase component I, non-proteobacterial lineages; This enzyme resembles some ... |
40-455 |
1.91e-128 |
|
anthranilate synthase component I, non-proteobacterial lineages; This enzyme resembles some other chorismate-binding enzymes, including para-aminobenzoate synthase (pabB) and isochorismate synthase. There is a fairly deep split between two sets, seen in the pattern of gaps as well as in amino acid sequence differences. Archaeal enzymes have been excluded from this model (and are now found in TIGR01820) as have a clade of enzymes which constitute a TrpE paralog which may have PabB activity (TIGR01824). This allows the B. subtilus paralog which has been shown to have PabB activity to score below trusted to this model. This model contains sequences from gram-positive bacteria, certain proteobacteria, cyanobacteria, plants, fungi and assorted other bacteria.A second family of TrpE enzymes is modelled by TIGR00565. The breaking of the TrpE family into these diverse models allows for the separation of the models for the related enzyme, PabB. [Amino acid biosynthesis, Aromatic amino acid family]
Pssm-ID: 273142 [Multi-domain] Cd Length: 454 Bit Score: 379.76 E-value: 1.91e-128
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 40 FMLESLGEESHISRHSIIGFDPEQILWATEGELHVQGRDGAvnSYASDNPYYLLREIVPQNIISRK------YAGGLTGY 113
Cdd:TIGR00564 19 FLLESAEPGSERGRYSFIGLNPVLTIKTEGGTEYLGADDRR--SGIVGNPLDEIRDVMETFAQHSDpelpipFTGGAVGY 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 114 IGYDCMNYFEPsLKLQHSD---MFDVfRFGVFKDGLILDKMTGEVIYFHY---DDSR------LETIEQILAE------P 175
Cdd:TIGR00564 97 LGYDTVRLFEK-ITLPPPDplnLPDA-YLMLCDDFIIFDHVTDKLYLIHNnrtTASRsakaaaDARLEALVADlqdpllP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 176 AVSNGPLQVTPMGETMTQAEHAAAVMKVKQDIIDGKVFQceVGFKKRF--RLEGDTINLYEQLREVNPSPQMYYVKFGEQ 253
Cdd:TIGR00564 175 EVPVPYPAALSFTSNYEKEEYEANVAKAKEYIKAGDIFQ--VVLSQRFeaKTEAPPFELYRVLRIVNPSPYMYYLDFGDF 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 254 KLIGASPELLFRLRQGEMETFPLAGTTKRGANEVEDTQFARTLLNDPKEIAEHNMIVDLHRNDIGRVARFGTVKVRSLMD 333
Cdd:TIGR00564 253 QIVGSSPELLVKVTGGRITTRPIAGTRKRGATPEEDEALAEELLADEKERAEHLMLVDLGRNDIGRVCEPGSVEVPEFMK 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 334 IKRFSHVQHISSEIVGIISEDHDMFSALASNFPAGTLTGAPKIEAMKIIDDLESDGRGPYGGAVGHFSFNGDCTFAIPIR 413
Cdd:TIGR00564 333 IERYSHVMHIVSTVEGRLKDGLTAIDALRATFPAGTVSGAPKIRAMELIDELEPEKRGIYGGAVGYLSFDGDMDTAIAIR 412
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 2197122856 414 TVFANGENAYVQTCGGNVYDSNPEDEYEEIRRKFAGTKKVLD 455
Cdd:TIGR00564 413 TMVVKDGKAYVQAGGGIVADSDPEAEYEETLNKARALLRAIE 454
|
|
| PRK13574 |
PRK13574 |
anthranilate synthase component I; Provisional |
26-451 |
2.87e-101 |
|
anthranilate synthase component I; Provisional
Pssm-ID: 184155 [Multi-domain] Cd Length: 420 Bit Score: 309.05 E-value: 2.87e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 26 FGLFKKIEKRFDNCFMLESLGEESHISRHSIIGfdpeqilWATEGELHVQG-RDGAVNSYASDnpyyllreiVPQNIISR 104
Cdd:PRK13574 13 FEVFKCIERDFKVAGLLESIGGPQYKARYSVIA-------WGTNGYLKIHDdPVNILNSYLKD---------LKLVDIPG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 105 KYAGGLTGYIGYDCMNYFEP--SLKLQHSDMFDVfRFGVFKDGLILDKMTGEViYFHYDDSRLETIEQIlaepavsnGPL 182
Cdd:PRK13574 77 LFKGGMIGYISYDAVRFWEKirDLKPAAEDWPYA-EFFIPDNIIIYDHNEGKV-YVNGDLSSVGGCGDM--------GEF 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 183 QVTPMGETMTQAEHAAAVMKVKQDIIDGKVFQCEVGFKKRFRLEGDTINLYEQLREVNPSPQMYYVKFGEQKLIGASPEL 262
Cdd:PRK13574 147 KISFYDESLNKNNYEKIVSESLEYIRSGYIFQVVLSRFYRYLFSGDPLRIYYNLRRINPSPYMFYLKFDERYLIGSSPEL 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 263 LFRLRQGEMETFPLAGTTKRGANEVEDTQFARTLLNDPKEIAEHNMIVDLHRNDIGRVARFGTVKVRSLMDIKRFSHVQH 342
Cdd:PRK13574 227 LFRVQDNIVETYPIAGTRPRGSDQEEDLKLELELMNSEKDKAEHLMLVDLARNDLGKVCVPGTVRVPELMYVEKYSHVQH 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 343 ISSEIVGIISEDHDMFSALASNFPAGTLTGAPKIEAMKIIDDLESDGRGPYGGAVGHFSFNGDCTFAIPIRTVFANGENA 422
Cdd:PRK13574 307 IVSKVIGTLKKKYNALDVLKATFPAGTVSGAPKPMAMNIIETLEEYKRGPYAGAVGFISADGNAEFAIAIRTAFLNKDLL 386
|
410 420
....*....|....*....|....*....
gi 2197122856 423 YVQTCGGNVYDSNPEDEYEEIRRKFAGTK 451
Cdd:PRK13574 387 RIQAGAGIVYDSNPESEYFETEHKLRALK 415
|
|
| Chorismate_bind |
pfam00425 |
chorismate binding enzyme; This family includes the catalytic regions of the chorismate ... |
194-446 |
5.48e-101 |
|
chorismate binding enzyme; This family includes the catalytic regions of the chorismate binding enzymes anthranilate synthase, isochorismate synthase, aminodeoxychorismate synthase and para-aminobenzoate synthase.
Pssm-ID: 425674 [Multi-domain] Cd Length: 255 Bit Score: 302.16 E-value: 5.48e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 194 AEHAAAVMKVKQDIIDGKVFQCEVG--FKKRFRLEGDTINLYEQLREVNPSPQMYYVKFGEQKLIGASPELLFRLRQGEM 271
Cdd:pfam00425 1 EDYLAAVEKAKEAIRAGDLYKVVLSrrLTLPLAGDIDPLALYRRLRARNPAPYSFYFRTGDFTFLGASPERLLSVDGGRI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 272 ETFPLAGTTKRGANEVEDTQFARTLLNDPKEIAEHNMIVDLHRNDIGRVARFGTVKVRSLMDIKRFSHVQHISSEIVGII 351
Cdd:pfam00425 81 ITEPIAGTRPRGKDPAEDEALAAELLADPKERAEHLMVVDLIRNDLGRVCVPGSVKVPELPEVERYGTVQHLVSTISGRL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 352 SEDHDMFSALASNFPAGTLTGAPKIEAMKIIDDLESDGRGPYGGAVGHFSFNGDCTFAIPIRTVFANGENAYVQTCGGNV 431
Cdd:pfam00425 161 KPGLSLLDLLKALFPTGAVTGAPKKRAMEIIRELEPFPRGLYAGAVGYLDPDGDADFAVAIRTALVDNGRARLYAGAGIV 240
|
250
....*....|....*
gi 2197122856 432 YDSNPEDEYEEIRRK 446
Cdd:pfam00425 241 ADSDPEAEWEETEAK 255
|
|
| PRK13572 |
PRK13572 |
anthranilate synthase component I; Provisional |
34-455 |
4.06e-98 |
|
anthranilate synthase component I; Provisional
Pssm-ID: 237432 [Multi-domain] Cd Length: 435 Bit Score: 301.66 E-value: 4.06e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 34 KRFDNCFMLESLGEESHISRHSIIGFDPEQILWATEGELhvqgRDGAVNSYASdNPYYLLREIVPQNIISRKYAGGLTGY 113
Cdd:PRK13572 19 RDEGYPFILESAEKGQRKARYTYISANPEFMVRIGNKTK----VDGETISKES-NPFKALKENFKITQSGDRFTGGFVGY 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 114 IGYDCM-NYF-----EPSlklqhsdmfdvfRFGVFKDGLILDKMTGEvIYFHY---DDSRLETIEQIL-----AEPAVSN 179
Cdd:PRK13572 94 IAYDAVhNYIggkieEPS------------VFGYYDHVFVYDHVTRK-FYFHSlnnNPEELFNAEKIVekakrFEIEEED 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 180 GPLQVtpMGETMTQAEHAAAVMKVKQDIIDGKVFQCEVGFKKRFRLEGDTINLYEQLREVNPSPQMYYVKFgEQKLIGAS 259
Cdd:PRK13572 161 GGSEV--LGCDADREEFVEMVEKAKEYIYSGDVFQVVLSREYRLKTDLSPFQLYRNLREINPSPYMFLLEF-DKDVVGAS 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 260 PELLFRLRQGEMETFPLAGTTKRGANEVEDTQFARTLLNDPKEIAEHNMIVDLHRNDIGRVARFGTVKVRSLMDIKRFSH 339
Cdd:PRK13572 238 PETMASVENNILKINPIAGTAPRGKTEEEDKKLAEALLSDEKERAEHVMLVDLARNDVRKVSKSGSVRLERFFDVVKYSH 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 340 VQHISSEIVGIISEDHDMFSALASNFPAGTLTGAPKIEAMKIIDDLESDGRGPYGGAVGHFSFNGDCTFAIPIRTVFANG 419
Cdd:PRK13572 318 VQHIESEVVGELKEDSTMFDAIEAAFPAGTLTGAPKFRAMEIIDELEKSRRKVYGGAVGYFSNSGNADLAIAIRMAEIDK 397
|
410 420 430
....*....|....*....|....*....|....*.
gi 2197122856 420 EnAYVQTCGGNVYDSNPEDEYEEIRRKFAGTKKVLD 455
Cdd:PRK13572 398 V-CRVRAGAGIVADSVPEKEFYETERKMAAVLKALG 432
|
|
| PRK13571 |
PRK13571 |
anthranilate synthase component I; Provisional |
40-448 |
2.13e-93 |
|
anthranilate synthase component I; Provisional
Pssm-ID: 184152 [Multi-domain] Cd Length: 506 Bit Score: 291.54 E-value: 2.13e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 40 FMLESLGEESHISRHSIIGFDPEQILWATEGELHVQGRDgAVNSYASDNPYYLLREIVPQNIISR-----KYAGGLTGYI 114
Cdd:PRK13571 51 FLLESAENGRSWSRWSFIGVGSPAALTVRDGEAVWLGTP-PAGAPTGGDPLAALRATLELLATPRlpglpPLTGGMVGFL 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 115 GYDCMNYFE--PSL---KLQHSDMfdvfRFGVFKDGLILDKMTGEVIYFH---------------YDD--SRLETIEQIL 172
Cdd:PRK13571 130 GYDAVRRLErlPELavdDLGLPEM----LLLLATDLAAVDHHEGTITLIAnavnwngtdervdaaYDDavARLDVMTAAL 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 173 AEPAVSNGPLQVTPMGETMTQ---AEHAAAVMKVKQDIIDGKVFQceVGFKKRFRLE--GDTINLYEQLREVNPSPQMYY 247
Cdd:PRK13571 206 AQPLPSTVATFSRPVPEFRAQrtvEEFGAAVEKLVEEIRAGEAFQ--VVPSQRFEMDttADPLDVYRVLRVTNPSPYMYL 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 248 VKFGEQK------LIGASPELLFRLRQGEMETFPLAGTTKRGANEVEDTQFARTLLNDPKEIAEHNMIVDLHRNDIGRVA 321
Cdd:PRK13571 284 LRVPNSDggtdfsIVGSSPEALVTVTDGRATTHPIAGTRWRGATPEEDALLEKELLADPKERAEHLMLVDLGRNDLGRVC 363
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 322 RFGTVKVRSLMDIKRFSHVQHISSEIVGIISEDHDMFSALASNFPAGTLTGAPKIEAMKIIDDLESDGRGPYGGAVGHFS 401
Cdd:PRK13571 364 RPGTVRVVDFSHIERYSHVMHLVSTVTGELAEGRTALDAVTACFPAGTLSGAPKVRAMELIEELEPTRRGLYGGVVGYLD 443
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 2197122856 402 FNGDCTFAIPIRTVFANGENAYVQTCGGNVYDSNPEDEYEEIRRKFA 448
Cdd:PRK13571 444 FAGDADTAIAIRTALMRDGTAYVQAGGGVVADSDPDYEDNEARNKAA 490
|
|
| PLN02445 |
PLN02445 |
anthranilate synthase component I |
40-460 |
6.99e-92 |
|
anthranilate synthase component I
Pssm-ID: 215244 [Multi-domain] Cd Length: 523 Bit Score: 288.12 E-value: 6.99e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 40 FMLESL---GEESHISRHSIIGFDPEQILWATEGELHVQGRD-GAVNSYASDNPYYLLREIV----PQNI--ISRKYAGG 109
Cdd:PLN02445 42 FLFESVepgSQSSNVGRYSVVGAQPAMEIVAKENKVTIMDHEkGTRTEEIVEDPMEIPRRISekwnPQLIdgLPDVFCGG 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 110 LTGYIGYDCMNYFEPSlKLQHSD-------MFDVfRFGVFKDGLILDKMTGEVIYFH-------------YDD--SRLET 167
Cdd:PLN02445 122 WVGYFSYDTVRYVEKK-KLPFSGapeddrnLPDI-HLGLYDDVIVFDHVEKKAYVIHwvrldryssveeaYEDgmKRLEA 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 168 IEQILAEPAVSNGP-----LQVTPMGE-----TMTQAEHAAAVMKVKQDIIDGKVFQceVGFKKRF--RLEGDTINLYEQ 235
Cdd:PLN02445 200 LVSRLQDINPPKLSpgsvkLSTNQFGPsleksNMTSEEYKNAVLQAKEHILAGDIFQ--IVLSQRFerRTFADPFEVYRA 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 236 LREVNPSPQMYYVKFGEQKLIGASPELLFRLRQGEMETFPLAGTTKRGANEVEDTQFARTLLNDPKEIAEHNMIVDLHRN 315
Cdd:PLN02445 278 LRIVNPSPYMIYLQARGCILVASSPEILTRVKKNKIVNRPLAGTRRRGKTPEEDKALEKDLLADEKQCAEHIMLVDLGRN 357
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 316 DIGRVARFGTVKVRSLMDIKRFSHVQHISSEIVGIISEDHDMFSALASNFPAGTLTGAPKIEAMKIIDDLESDGRGPYGG 395
Cdd:PLN02445 358 DVGKVSKAGSVKVEKLMNIERYSHVMHISSTVTGELLDHLTSWDALRAALPVGTVSGAPKVRAMELIDELEVTRRGPYSG 437
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 396 AVGHFSFNGDCTFAIPIRT-VFANGEN-----------------AYVQTCGGNVYDSNPEDEYEEIRRKFAGTKKVLDqf 457
Cdd:PLN02445 438 GFGGVSFTGDMDIALALRTmVFPTAARydtmysykdtnsrrewvAHLQAGAGIVADSDPEDEYRECVNKAAGLARAID-- 515
|
...
gi 2197122856 458 IAE 460
Cdd:PLN02445 516 LAE 518
|
|
| pabB |
TIGR00553 |
aminodeoxychorismate synthase, component I, bacterial clade; Members of this family, ... |
160-446 |
1.52e-80 |
|
aminodeoxychorismate synthase, component I, bacterial clade; Members of this family, aminodeoxychorismate synthase, component I (PabB), were designated para-aminobenzoate synthase component I until it was recognized that PabC, a lyase, completes the pathway of PABA synthesis. This family is closely related to anthranilate synthase component I (trpE), and both act on chorismate. The clade of PabB enzymes represented by this model includes sequences from Gram-positive and alpha and gamma Proteobacteria as well as Chlorobium, Nostoc, Fusobacterium and Arabidopsis. A closely related clade of fungal PabB enzymes is identified by TIGR01823, while another bacterial clade of potential PabB enzymes is more closely related to TrpE (TIGR01824). [Biosynthesis of cofactors, prosthetic groups, and carriers, Folic acid]
Pssm-ID: 273133 Cd Length: 328 Bit Score: 252.68 E-value: 1.52e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 160 YDDSRLETIEQILAEPAVS-NGPLQVTPMGETMTQAEHAAAVMKVKQDIIDGKVFQCEVGFKKRFRLEGDTINLYEQLRE 238
Cdd:TIGR00553 37 FERVEAQPRAAVEAEDDAPaDRQAPTSDIQSEMTRAEYGEAIDQLQDYIRAGDCYQANLTQQFHATWDGDPLAAFRKLRR 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 239 VNPSPQMYYVKFGEQKLIGASPELLFRLRQGEMETFPLAGTTKRGANEVEDTQFARTLLNDPKEIAEHNMIVDLHRNDIG 318
Cdd:TIGR00553 117 RQPAPFSAFLDLGDGAILSLSPELFFSIDGSEIETRPIKGTLPRGADPQEDRAQASALAESAKDRAENLMIVDLLRNDLG 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 319 RVARFGTVKVRSLMDIKRFSHVQHISSEIVGIISEDHDMFSALASNFPAGTLTGAPKIEAMKIIDDLESDGRGPYGGAVG 398
Cdd:TIGR00553 197 RIAEVGSVKVPELFVVETYPTVHQLVSTITARLREDLTLSDLFRALFPGGSITGAPKVRAMEIIDELEPQPRGVYCGAIG 276
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 2197122856 399 HFSFNGDCTFAIPIRTVFANGENAYVQTCGGNVYDSNPEDEYEEIRRK 446
Cdd:TIGR00553 277 YLSPEGDMDFNVAIRTLTLDGGRAVYGVGGGIVADSDPEAEYRECLLK 324
|
|
| PabB-clade2 |
TIGR01824 |
aminodeoxychorismate synthase, component I, clade 2; This clade of sequences is more closely ... |
164-449 |
1.58e-79 |
|
aminodeoxychorismate synthase, component I, clade 2; This clade of sequences is more closely related to TrpE (anthranilate synthase, TIGR00564/TIGR01820/TIGR00565) than to the better characterized group of PabB enzymes (TIGR00553/TIGR01823). This clade includes one characterized enzyme from Lactococcus and the conserved function across the clade is supported by these pieces of evidence: 1) all genomes with a member in this clade also have a separate TrpE gene, 2) none of these genomes contain an aparrent PabB from any of the other PabB clades, 3) none of these sequences are found in a region of the genome in association with other Trp biosynthesis genes, 4) all of these genomes aparrently contain most if not all of the steps of the folate biosynthetic pathway (for which PABA is a precursor). Many of the sequences hit by this model are annotated as TrpE enzymes, however, we believe that all members of this clade are, in fact, PabB. The sequences from Bacillus halodurans and subtilus which score below the trusted cutoff for this model are also likely to be PabB enzymes, but are too closely related to TrpE to be separated at this time.
Pssm-ID: 130883 Cd Length: 355 Bit Score: 250.85 E-value: 1.58e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 164 RLETIEQILAEPAVSNGPLQVTpMGETMTQAEHAAAVMKVKQDIIDGKVFQCEVG--FKKRFRLEGDTINLYEQLREVNP 241
Cdd:TIGR01824 68 QLPAVAAATSLPSPDVGPLPVD-LEASIDRAAYETGVRRIKDYIRAGDVFQANLSrrLTAPIAADVDPLQLFLALRAPNP 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 242 SPQMYYVKFGEQKLIGASPELLFRLRQGEMETFPLAGTTKRGANEVEDTQFARTLLNDPKEIAEHNMIVDLHRNDIGRVA 321
Cdd:TIGR01824 147 APYAIYLEEPGVDVASASPELFLAREGRVVQTRPIAGTRPRGATLAEDGALAAELLQHDKDRAEHVMIVDLERNDLGRVC 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 322 RFGTVKVRSLMDIKRFSHVQHISSEIVGIISEDHDMFSALASNFPAGTLTGAPKIEAMKIIDDLESDGRGPYGGAVGHFS 401
Cdd:TIGR01824 227 ATGTVRVPELCAVESYSHVHHLVSRVTGRLREGAGLADLIRALFPGGSITGAPKVRAMEIIDELEPQPRGPYTGSVGWID 306
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 2197122856 402 FNGDCTFAIPIRTVFANGENAYVQTCGGNVYDSNPEDEYEEIRRKFAG 449
Cdd:TIGR01824 307 ADGNADLNILIRTLEGGGAQLHFRTGAGIVADSDPAGEWDETEAKARA 354
|
|
| PRK09070 |
PRK09070 |
aminodeoxychorismate synthase component I; |
14-457 |
1.51e-74 |
|
aminodeoxychorismate synthase component I;
Pssm-ID: 236371 [Multi-domain] Cd Length: 447 Bit Score: 240.76 E-value: 1.51e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 14 PHYVTLAADIDFFGLFKKIEKRFDncFMLESLGEESHISRHSIIGFDPE-QILWATEGelhvQGRDGAVNSYASDNPYYL 92
Cdd:PRK09070 2 TLTRPLPADIDLLALHRLAPERYP--ALLESSASGTAQGRWDVLLLAQGkCLRLDPDG----VTRQLLEGDFLDALDAAW 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 93 LREIVPQNIISR-KYAGGLTGYIGYDCMNYFEPSLKL-QHSDMFDVFRFGVFKDGLILDKMTGEvIYFHYDDSRLETIEQ 170
Cdd:PRK09070 76 QAERVPHDGESSlPFRGGWAVLLDYELAGQVEPILKLpMRTDGLPLALALRAPAAVLRDRHSGR-CVLVAEPGREHLLDQ 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 171 ILAEPAVSNG--PLQVTPMGETMTQAEHA---AAVMKVKQDIIDGKVFQCEV--GFKKRFRLEGDTINLYEQLREVNPSP 243
Cdd:PRK09070 155 IEADLAACAAlpPLPVWLAPQAVEEDPPErftDGVERVLDYIRAGDVFQVNLsrAWQAQFANAVDPAALYARLRAANPAP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 244 QMYYVKFGEQKLIGASPELLFRLRQGEMETFPLAGTTKRGANEvEDTQFARTLLNDPKEIAEHNMIVDLHRNDIGRVARF 323
Cdd:PRK09070 235 FSGLFVAAGRAIVSSSPERLVSVQGGVVQTRPIAGTRPRFAGD-DDAALIRELVGHPKERAEHVMLIDLERNDLGRICAP 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 324 GTVKVRSLMDIKRFSHVQHISSEIVGIISED---HDMFSALasnFPAGTLTGAPKIEAMKIIDDLESDGRGPYGGAVGHF 400
Cdd:PRK09070 314 GSVEVDELMTVESYAHVHHIVSNVRGRLRDGvtpGEVIRAV---FPGGTITGCPKVRCMQIIAELEQTPRGAYTGSFGYL 390
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 2197122856 401 SFNGDCTFAIPIRTVFANGENAYVQTCGGNVYDSNPEDEYEEIRRKFAGTKKVLDQF 457
Cdd:PRK09070 391 NRDGDMDLNILIRTAEVQGNQVRFRTGAGIVVDSDPERELDETRAKARGLLRALEQA 447
|
|
| PRK05940 |
PRK05940 |
anthranilate synthase component I; |
106-442 |
1.39e-64 |
|
anthranilate synthase component I;
Pssm-ID: 235651 [Multi-domain] Cd Length: 463 Bit Score: 215.36 E-value: 1.39e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 106 YAGGLTGYIGYDCMNYFEpslKLQHSDMfDVFRFGV--------FKdglILDKMTGEVIYFHYDDSRLETIEQILAEPAV 177
Cdd:PRK05940 96 FTGGWLGWLGYDLAWEIE---RLPHLNP-DPLPFPVaywyepesFA---ILDHQEQILWLAASDPSQLDRLEQQLEQPTP 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 178 SNG---PLQVTPMG--ETMTQAEHAAAVMKVKQDIIDGKVFQCEVGFkkRFRLEG--DTINLYEQLREVNPSPQMYYVK- 249
Cdd:PRK05940 169 EPDlplDLRTPPSSliFYTTQQEYEAAVRQAKKYIQAGDIFQANLSL--RFQTTTsaDSWQIYRRLQQINPSPFASYWRt 246
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 250 -FGEqkLIGASPELLFRLRQGEMETFPLAGTTKRGANEVEDTQFARTLLNDPKEIAEHNMIVDLHRNDIGRVARFGTVKV 328
Cdd:PRK05940 247 pWGD--VVSCSPERLVQLQGNQAQTRPIAGTRPRGKTPAEDQQLAEELLSNIKERAEHIMLVDLERNDLGRVCQWGSVEV 324
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 329 RSLMDIKRFSHVQHISSEIVGIISEDHDMFSALASNFPAGTLTGAPKIEAMKIIDDLESDGRGPYGGAVGHFSFNGDCTF 408
Cdd:PRK05940 325 DELLTIERYSHVIHLVSNVVGTLQPNRDAIDLIRALFPGGTITGCPKVRCMEIIEELEPVRRNLFYGSCGYLDQRGNLDL 404
|
330 340 350
....*....|....*....|....*....|....*....
gi 2197122856 409 AIPIRT-VFANGENAYVQTCG----GNVYDSNPEDEYEE 442
Cdd:PRK05940 405 NILIRTlLYTPLSRGLSTIWGqvgaGIVADSDPEKEWLE 443
|
|
| PRK13564 |
PRK13564 |
anthranilate synthase component 1; |
163-446 |
3.36e-64 |
|
anthranilate synthase component 1;
Pssm-ID: 237428 [Multi-domain] Cd Length: 520 Bit Score: 215.85 E-value: 3.36e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 163 SRLETIEQILAEPAVsngPLQVTPMGETMTQA-----EHAAAVMKVKQDIIDGKVFQceVGFKKRFRLE-GDTINLYEQL 236
Cdd:PRK13564 210 ARLAQLKQQLTQPAP---PLPVTSVPDMEVSVnisdeEFCAVVRKLKEHIRAGDIFQ--VVPSRRFSLPcPSPLAAYRVL 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 237 REVNPSPQMYYVKFGEQKLIGASPE--LLFRLRQGEMETFPLAGTTKRGAN-------------EVEdtqfartLLNDPK 301
Cdd:PRK13564 285 KKSNPSPYMFYMQDEDFTLFGASPEsaLKYDASSRQVEIYPIAGTRPRGRRadgsidrdldsriELE-------LRTDHK 357
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 302 EIAEHNMIVDLHRNDIGRVARFGTVKVRSLMDIKRFSHVQHISSEIVGIISEDHDMFSALASNFPAGTLTGAPKIEAMKI 381
Cdd:PRK13564 358 ELAEHLMLVDLARNDLARICQPGSRYVADLLKVDRYSHVMHLVSRVVGELRHDLDALHAYRACMNMGTLTGAPKVRAMQL 437
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2197122856 382 IDDLESDGRGPYGGAVGHFSFNGDCTFAIPIRTVF-ANGEnAYVQTCGGNVYDSNPEDEYEEIRRK 446
Cdd:PRK13564 438 IREVEGQRRGSYGGAVGYLTGHGDLDTCIVIRSAFvENGI-ATVQAGAGVVLDSDPQSEADETRNK 502
|
|
| PRK07508 |
PRK07508 |
aminodeoxychorismate synthase component I; |
190-442 |
1.50e-62 |
|
aminodeoxychorismate synthase component I;
Pssm-ID: 236035 [Multi-domain] Cd Length: 378 Bit Score: 207.56 E-value: 1.50e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 190 TMTQAEHAAAVMKVKQDIIDGKVFQCEVGFKKRFRLEGDTINLYEQLREVNPSPQMYYVKFGEQKLIGASPELLFRLR-Q 268
Cdd:PRK07508 108 RWDFADYAQRFERLHRHIRAGDCYQANLTFPLDARWGGDPLALFWALAARQPVGYGALVDLGGPVILSRSPELFFRVDgE 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 269 GEMETFPLAGTTKRGANEVEDTQFARTLLNDPKEIAEHNMIVDLHRNDIGRVARFGTVKVRSLMDIKRFSHVQHISSEIV 348
Cdd:PRK07508 188 GWIETHPMKGTAPRGATPAEDARLRAALLNDEKNQAENRMIVDLLRNDISRISEVGSLDVPELFDIETYPTVHQMVSRVR 267
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 349 GIISED---HDMFSALasnFPAGTLTGAPKIEAMKIIDDLESDGRGPYGGAVGHFSFNGDCTFAIPIRTV--FANGEnAY 423
Cdd:PRK07508 268 ARLLPGlglADIFAAL---FPCGSITGAPKIRAMEILRELEPGPRDLYCGAIGWIAPDGRMRFNVAIRTLslFPGGR-AV 343
|
250
....*....|....*....
gi 2197122856 424 VQTCGGNVYDSNPEDEYEE 442
Cdd:PRK07508 344 FNVGGGIVFDSTAEAEYEE 362
|
|
| PRK13567 |
PRK13567 |
anthranilate synthase component I; Provisional |
37-446 |
1.56e-60 |
|
anthranilate synthase component I; Provisional
Pssm-ID: 184148 [Multi-domain] Cd Length: 468 Bit Score: 204.99 E-value: 1.56e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 37 DNCFMLESLGEESHISRHSIIGFDPEQILWATEGELHVQGRDgavNSYASDN-PYYLLREIVPQ--NIISRKYAGGL--- 110
Cdd:PRK13567 22 SKKIILESTNQQQTKGRYSVVIFDIYGTLTLDNDVLSVSTLK---ESYQITErPYHYLTTKINEdyHNIQDEQLKSLpfi 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 111 TGYIG---YDCMNYFEPSLK-------LQHSDMF----DVFRFGVFKDGL------ILDKMTGEVIYFHYDDsRLETIEQ 170
Cdd:PRK13567 99 SGYVGtcsFDLVRHEFPKLQsiqledhKQHDVRLymveQVYVFDHYKDELyiiatnQFSNSTKSDLENRVNK-SIEDLTK 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 171 IlaEPAVSNGPLQVTP--MGETMTQAEHAAAVMKVKQDIIDGKVFQCE----VGFKKRF--RLEGDTINLYEQLREVNPS 242
Cdd:PRK13567 178 I--QPFMPTQDFDFKTkeIQSNISEERFIEMIQYFKEKITEGDMFQVVpsriYKYAHHAsqHLNQLSFQLYQNLKRQNPS 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 243 PQMYYVKFGEQKLIGASPELLFRLRQGEMETFPLAGTTKRGANEVEDTQFARTLLNDPKEIAEHNMIVDLHRNDIGRVAR 322
Cdd:PRK13567 256 PYMYYLNIDQPYIVGSSPESFVSVKDQIVTTNPIAGTIQRGETTQIDNENMKQLLNDPKECSEHRMLVDLGRNDIHRVSK 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 323 FGTVKVRSLMDIKRFSHVQHISSEIVGIISEDHDMFSALASNFPAGTLTGAPKIEAMKIIDDLESDGRGPYGGAVGHFSF 402
Cdd:PRK13567 336 IGTSKITKLMVIEKYEHVMHIVSEVTGKINQNLSPMTVIANLLPTGTVSGAPKLRAIERIYEQYPHKRGVYSGGVGYINC 415
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 2197122856 403 NGDCTFAIPIRTVFANGENAYVQTCGGNVYDSNPEDEYEEIRRK 446
Cdd:PRK13567 416 NHNLDFALAIRTMMIDEQYINVEAGCGVVYDSIPEKELNETKLK 459
|
|
| pabB |
PRK15465 |
aminodeoxychorismate synthase component 1; |
5-457 |
1.25e-59 |
|
aminodeoxychorismate synthase component 1;
Pssm-ID: 185362 [Multi-domain] Cd Length: 453 Bit Score: 202.07 E-value: 1.25e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 5 PARITLPRKPHyvtlAADIDFFGLfkkieKRFDNCFMLESLGEESHISRHSIIGFDPEQILwATEGELHVQgRDGAVNSY 84
Cdd:PRK15465 6 PAVITLPWRQD----AAEFYFSRL-----SHLPWAMLLHSGYADHPYSRFDIVVADPICTL-TTFGKETVV-SESEKRTT 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 85 ASDNPYYLLRE------IVPQNIISRKYAGGLTGYIGYDCMNYFE--PSLKLQHSDMFDVfRFGVFKDGLILDKMTGEVI 156
Cdd:PRK15465 75 TTDDPLQVLQQvldradIRPTHNEDLPFQGGALGLFGYDLGRRFEslPEIAEQDIVLPDM-AVGIYDWALIVDHQRQTVS 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 157 YFHYDD--SRLETIEqilAEPAVSNGPLQVTPMGET-MTQAEHAAAVMKVKQDIIDGKVFQceVGFKKRFR--LEGDTIN 231
Cdd:PRK15465 154 LLSHNDvnARRAWLE---SQQFSPQEDFTLTSDWQSnMTREQYGEKFRQVQEYLHSGDCYQ--VNLAQRFHatYSGDEWQ 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 232 LYEQLREVNPSPQMYYVKFGEQKLIGASPELLFRLRQGEMETFPLAGTTKRGANEVEDTQFARTLLNDPKEIAEHNMIVD 311
Cdd:PRK15465 229 AFLQLNQANRAPFSAFLRLEQGAILSLSPERFILCDNSEIQTRPIKGTLPRLPDPQEDSKQAEKLANSAKDRAENLMIVD 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 312 LHRNDIGRVARFGTVKVRSLMDIKRFSHVQHISSEIVGIISEDHDMFSALASNFPAGTLTGAPKIEAMKIIDDLESDGRG 391
Cdd:PRK15465 309 LMRNDIGRVAVAGSVKVPELFVVEPFPAVHHLVSTITARLPEQLHASDLLRAAFPGGSITGAPKVRAMEIIDELEPQRRN 388
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2197122856 392 PYGGAVGHFSFNGDCTFAIPIRTVFANGENAYVQTCGGNVYDSNPEDEYEEirrKFAGTKKVLDQF 457
Cdd:PRK15465 389 AWCGSIGYLSFCGNMDTSITIRTLTAINGQIYCSAGGGIVADSQEEAEYQE---TFDKVNRILRQL 451
|
|
| MenF |
COG1169 |
Isochorismate synthase EntC [Coenzyme transport and metabolism, Secondary metabolites ... |
189-454 |
1.47e-47 |
|
Isochorismate synthase EntC [Coenzyme transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]; Isochorismate synthase EntC is part of the Pathway/BioSystem: Menaquinone biosynthesis
Pssm-ID: 440783 [Multi-domain] Cd Length: 353 Bit Score: 167.25 E-value: 1.47e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 189 ETMTQAEHAAAVMKVKQDIIDGKvfqcevgFKK-------RFRLEG--DTINLYEQLREVNPSPQMYYVKFGEQK-LIGA 258
Cdd:COG1169 84 GVPDPAEWREAVAQALEAIRAGE-------LDKvvlaralDLTLDEpiDPRALLARLRRRNPDCYTFAVELGAGDgFVGA 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 259 SPELLFRLRQGEMETFPLAGTTKRGANEVEDTQFARTLLNDPKEIAEHNMIVDlhrnDI-GRVARFG-TVKVRSLMDIKR 336
Cdd:COG1169 157 SPERLVRRRGGQLTTEALAGTAPRGADPEEDAALAAALLASEKDRREHALVVD----SIrEALAPLCsSLDVPEEPELLR 232
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 337 FSHVQHISSEIVGIISEDHDMFSALASNFPAGTLTGAPKIEAMKIIDDLESDGRGPYGGAVGHFSFNGDCTFAIPIRTVF 416
Cdd:COG1169 233 LRNVQHLATPITGTLDPGVSALDLAAALHPTPAVGGTPREAALALIRELEPFDRGWYAGPVGWVDADGDGEFAVAIRSAL 312
|
250 260 270
....*....|....*....|....*....|....*...
gi 2197122856 417 ANGENAYVQTCGGNVYDSNPEDEYEEIRRKFAGTKKVL 454
Cdd:COG1169 313 IDGNRARLFAGAGIVAGSDPEAEWAETEAKLRTMLRAL 350
|
|
| PLN02889 |
PLN02889 |
oxo-acid-lyase/anthranilate synthase |
106-443 |
1.81e-47 |
|
oxo-acid-lyase/anthranilate synthase
Pssm-ID: 215481 [Multi-domain] Cd Length: 918 Bit Score: 175.42 E-value: 1.81e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 106 YAGGLTGYIGYDCMNYFEPSLKLQHSDMFDVFRFgvFKDGLIldkmtgeVIYFHYDD--------------SRLETIEQI 171
Cdd:PLN02889 538 FHGGYVGYIGYDLKVECGMASNRHKSTTPDACFF--FADNVV-------VIDHHYDDvyilslhegstattQWLDDTEQK 608
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 172 L--------------AEPAVSNGPLQVTPMGETmTQAEHAAAVMKVKQDIIDGKVFQCEVGFKKRFRL-EGDTINLYEQL 236
Cdd:PLN02889 609 LlglkasatrklevqTSPTATFSPSKAGFLADK-SREQYIKDVQKCLKYIKDGESYELCLTTQMRKRIgEIDSLGLYLHL 687
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 237 REVNPSPQMYYVKFGEQKL--IGASPELLFRL-RQGEMETFPLAGTTKRGANEVEDTQFARTLLNDPKEIAEHNMIVDLH 313
Cdd:PLN02889 688 REKNPAPYAAWLNFSNENLciCSSSPERFLKLdRNGMLEAKPIKGTIARGSTPEEDEQLKLQLQYSEKDQAENLMIVDLL 767
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 314 RNDIGRVARFGTVKVRSLMDIKRFSHVQHISSEIVGIISEDHDMFSALASNFPAGTLTGAPKIEAMKIIDDLESDGRGPY 393
Cdd:PLN02889 768 RNDLGRVCEPGSVHVPNLMDVESYTTVHTMVSTIRGKKRSNMSPVDCVRAAFPGGSMTGAPKLRSMELLDSLESSSRGIY 847
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 2197122856 394 GGAVGHFSFNGDCTFAIPIRTVFANGENAYVQTCGGNVYDSNPEDEYEEI 443
Cdd:PLN02889 848 SGSIGFFSYNQTFDLNIVIRTVVIHEGEASIGAGGAIVALSNPEDEYEEM 897
|
|
| PRK13566 |
PRK13566 |
anthranilate synthase component I; |
195-446 |
1.40e-44 |
|
anthranilate synthase component I;
Pssm-ID: 237429 [Multi-domain] Cd Length: 720 Bit Score: 165.86 E-value: 1.40e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 195 EHAAAVMKVKQDIIDGKVFQCEVGFKKRFRLEGDTINLYEQLREVNPSPQMYYVKFGEQK-LIGASPELLFRLRQGEMET 273
Cdd:PRK13566 245 EYAALVEKAKESFRRGDLFEVVPGQTFYEPCERSPSEIFRRLKEINPSPYGFFINLGDGEyLVGASPEMFVRVEGRRVET 324
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 274 FPLAGTTKRGANEVEDTQFARTLLNDPKEIAEHNMIVDLHRNDIGRVARFGTVKVRSLMDIKRFSHVQHISSEIVGIISE 353
Cdd:PRK13566 325 CPISGTIKRGADAIGDAEQIRKLLNSKKDESELTMCTDVDRNDKSRVCEPGSVKVIGRRQIEMYSRLIHTVDHVEGRLRP 404
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 354 DHDMFSALASNFPAGTLTGAPKIEAMKIIDDLESDGRGPYGGAVGHFSFNGDCTFAIPIRTVFANGENAYVQ---TCggn 430
Cdd:PRK13566 405 GFDALDAFLTHAWAVTVTGAPKLWAMQFIEDHERSPRRWYGGAVGMVGFDGDMNTGLTLRTIRIKDGVAEVRvgaTL--- 481
|
250
....*....|....*.
gi 2197122856 431 VYDSNPEDEYEEIRRK 446
Cdd:PRK13566 482 LFDSDPEAEEAETELK 497
|
|
| PRK06404 |
PRK06404 |
anthranilate synthase component I; Reviewed |
230-446 |
1.34e-43 |
|
anthranilate synthase component I; Reviewed
Pssm-ID: 102361 [Multi-domain] Cd Length: 351 Bit Score: 156.57 E-value: 1.34e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 230 INLYEQLREV---NPSPQMYYVKFGEQKLIGASPELLFRLRQGEMETFPLAGTtkrganeVEDTQFARTLLNDPKEIAEH 306
Cdd:PRK06404 136 IDFKEKLSEFinnDRSRYVFYYRFGKYRVVGSSPENVFTVNGNIINVDPIAGT-------YDDKILSNELLNSEKDKLEH 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 307 NMIVDLHRNDIGRVARFGTVKVRSLMDIKRFSHVQHISSEIVGIISeDHDMFSALASNFPAGTLTGAPKIEAMKIIDDLE 386
Cdd:PRK06404 209 RMLLDLARNDLSKFADIGTLNVDKVMKIEEFSSVKHLVSQVTAKFS-NASYRDILASMFPAGTVSGSPKERAIEIINKYE 287
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 387 SDGRGPYGGAVGHFSfNGDCTFAIPIRTVFANGENAYVQTCGGNVYDSNPEDEYEEIRRK 446
Cdd:PRK06404 288 ETPRGPYGGAIGIIS-KGYTDMALVIRTAYSHGNGFRVRAGAGIVKDSDPEDEVNEIYSK 346
|
|
| isochor_syn |
TIGR00543 |
isochorismate synthases; This enzyme interconverts chorismate and isochorismate. In E. coli, ... |
176-454 |
5.24e-41 |
|
isochorismate synthases; This enzyme interconverts chorismate and isochorismate. In E. coli, different loci encode isochorismate synthases for the pathways of menaquinone biosynthesis and enterobactin biosynthesis (via salicilate) and fail to complement each other. Among isochorismate synthases, the N-terminal domain is poorly conserved. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]
Pssm-ID: 273127 Cd Length: 351 Bit Score: 149.83 E-value: 5.24e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 176 AVSNGPLQVTPM--GETMTQAEHAAAVMKVKQDIIDG---KVF---QCEVGFKKRFrlegDTINLYEQLREVNPSPQMYY 247
Cdd:TIGR00543 70 PLRALPEQMTTLttGEDPDKAAWRTAVEEALENIRQGpldKVVlarALTLKFADDI----DPIAVLANLRQQYPNAYIFL 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 248 VKFGEQK-LIGASPELLFRLRQGEMETFPLAGTTKRGANEVEDTQFARTLLNDPKEIAEHNMIVDLHRNDIGRVARfgTV 326
Cdd:TIGR00543 146 LEPPQGGvFLGATPERLLSREKGELLTEALAGTAPRSADPEEDRKLGELLLKDDKNLREHRLVVEYIRRRLQPICT--SL 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 327 KVRSLMDIKRFSHVQHISSEIVGIISEDHDMFSALASNFPAGTLTGAPKIEAMKIIDDLESDGRGPYGGAVGHFSFNGDC 406
Cdd:TIGR00543 224 DVSETPELLKLANVQHLYTPISARLKDGDSLLDLLKQLHPTPAVGGLPREEALDFIREHEPFDRGLYAAPLGWLDGEGNG 303
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 2197122856 407 TFAIPIRTVFANGENAYVQTCGGNVYDSNPEDEYEEIRRKFAGTKKVL 454
Cdd:TIGR00543 304 EFAVGIRSALVEDGQVRLYAGAGIVADSDPESEWEETELKLQTMLRAL 351
|
|
| PRK05877 |
PRK05877 |
aminodeoxychorismate synthase component I; Provisional |
166-448 |
6.75e-38 |
|
aminodeoxychorismate synthase component I; Provisional
Pssm-ID: 235634 [Multi-domain] Cd Length: 405 Bit Score: 142.54 E-value: 6.75e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 166 ETIEQILAEPAVSN-GPLQVTpmGETMTQAEHAAAVMKVKQDIIDGKVFQCEVGFKKRFRLEGDTINLY-EQLREVNPSP 243
Cdd:PRK05877 115 DWLASALATTRARPaPPCRID--WTPPDRAAHRDGVLACLEAIAAGEVYQACVCTQFTGTVTGSPLDFFaDGVARTAPAR 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 244 QMYYVkfGEQKLIGA-SPELLFRLRQGEMETFPLAGTTKRGANevedtqfARTLLNDPKEIAEHNMIVDLHRNDIGRVAR 322
Cdd:PRK05877 193 AAYLA--GDWGAVASlSPELFLRRRGSVVTSSPIKGTLPLDAD-------PSALRASAKDVAENIMIVDLVRNDLGRVAR 263
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 323 FGTVKVRSLMDIKRFSHVQHISSEIVGIISEDHDMFSALASNFPAGTLTGAPKIEAMKIIDDLESDGRGPYGGAVGHFSF 402
Cdd:PRK05877 264 TGTVTVPELLVVRPAPGVWHLVSTVSAQVPDELPMSDLLDATFPPASVTGTPKLRARELISQWEPVRRGIYCGTVGLASP 343
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 2197122856 403 NGDCTFAIPIRTV-FANGENAYVQTCGGNVYDSNPEDEYEEIRRKFA 448
Cdd:PRK05877 344 VAGCELNVAIRTVeFDADGNAVLGVGGGITADSDPDAEWQECLHKAA 390
|
|
| salicyl_syn |
TIGR03494 |
salicylate synthase; Members of this protein family are salicylate synthases, bifunctional ... |
237-448 |
4.27e-37 |
|
salicylate synthase; Members of this protein family are salicylate synthases, bifunctional enzymes that make salicylate, in two steps, from chorismate. Members are homologous to anthranilate synthase component I from Trp biosynthesis. Members typically are found in gene regions associated with siderophore or other secondary metabolite biosynthesis.
Pssm-ID: 132533 [Multi-domain] Cd Length: 425 Bit Score: 140.68 E-value: 4.27e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 237 REVNPSPQMYYVKFGEQKLIGASPELLFRLRQ-GEMETFPLAGTTKRGANEVEDTQFARTLLNDPKEIAEHNMIVDLHRN 315
Cdd:TIGR03494 205 RRHNTPVRSFLLRLGGIEALGFSPELVMSVRAdGKVVTEPLAGTRALGGGPEHDKQLRDELLSDSKEIVEHAISVKEAIE 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 316 DIGRVARFGTVKVRSLMDIKRFSHVQHISSEIVGIISEDHDMFSALASNFPAGTLTGAPKIEAMKIIDDLESDGRGPYGG 395
Cdd:TIGR03494 285 ELEQVCEPGTVVVEDFMTVRERGSVQHLGSTVSGQLAPSKDAWDAFEVLFPAITASGIPKAAALEAIMRLEKTPRGLYSG 364
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 2197122856 396 AVGHFSFNGDCTFAIPIRTVFANGENAYVQTCGGNVYDSNPEDEYEEIRRKFA 448
Cdd:TIGR03494 365 AVLLLDADGTLDAALVLRAAYQDSGRTWLQAGAGIIAQSTPERELTETCEKLA 417
|
|
| PRK07093 |
PRK07093 |
para-aminobenzoate synthase component I; Validated |
245-446 |
1.78e-31 |
|
para-aminobenzoate synthase component I; Validated
Pssm-ID: 235932 [Multi-domain] Cd Length: 323 Bit Score: 123.06 E-value: 1.78e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 245 MYYVKFGEQkLIGASPELLFRLRQGEMETFPLAGT---TKRGANEVedtqfartLLNDPKEIAEHNMIVDLHRNDIGRVA 321
Cdd:PRK07093 119 KYKLLFKDQ-FVCFSPEPFVRIEDNKISTYPMKGTidaSLPNAEEK--------LLNDEKEFAEHATIVDLLRNDLSMVA 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 322 RfgTVKVrslmdiKRFSHVQHI----------SSEIVGIISED-----HDMFSALasnFPAGTLTGAPKIEAMKIIDDLE 386
Cdd:PRK07093 190 K--NVRV------TRFRYIDKIktnkgeilqtSSEISGTLPENwqeniGDILAKL---LPAGSITGAPKEKTVEIIEQAE 258
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2197122856 387 SDGRGPYGGAVGHfsFNG-DCTFAIPIRTVFANGENAYVQTCGGNVYDSNPEDEYEEIRRK 446
Cdd:PRK07093 259 GYERGFYTGVFGY--FDGeSLDSAVMIRFIEQENDGLYFKSGGGITIDSDLKDEYNELIQK 317
|
|
| PRK07054 |
PRK07054 |
isochorismate synthase; |
159-456 |
1.81e-29 |
|
isochorismate synthase;
Pssm-ID: 235920 [Multi-domain] Cd Length: 475 Bit Score: 120.25 E-value: 1.81e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 159 HYDDSRLETIEQiLAEPAVSNGP--LQVTPMGETMTQAEHAAAVMKVKQDIIdGKVF----QCEvgfkkRFRLEGDTINL 232
Cdd:PRK07054 163 GACCARIERLAR-PAPAADDDAPrlLRASALQAREWQHEVRRAVDAIRGGAF-GKVVlardVLQ-----QYARPVAIGPL 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 233 YEQLREVNPSPQMYYVKFGEQKLIGASPELLFRLRQGEMETFPLAGTTKRGANEVEDTQFARTLLNDPKEIAEHNMIVDL 312
Cdd:PRK07054 236 LRRLRLRDPHAHLFAFRRGNACFLGATPERLVRVAAGDLHTHALAGTIARGADPAEDARLGAALMASAKDRLEHALVVDA 315
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 313 HRNDIGRVARfgTVKVRSLMDIKRFSHVQHISSEIVGIISEDHDMFSALASNFPAGTLTGAPKIEAMKIIDDLESDGRGP 392
Cdd:PRK07054 316 IRAALAPLSR--ALDIPDQPSLHRLPRLQHLSTPIRATLAPDATLLQVVAALHPTPAVGGHPRAAALDYIRAHEGFDRGW 393
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2197122856 393 YGGAVGHFSFNGDCTFAIPIRTVFANGENAYVQTCGGNVYDSNPEDEYEEIRRKFAGTKKVLDQ 456
Cdd:PRK07054 394 YAAPIGWLDAHGNGDFAVALRSALITGGACRLFAGCGIVADSEPASEYRETCLKLSGMREALRA 457
|
|
| PRK07912 |
PRK07912 |
salicylate synthase; |
233-448 |
8.81e-28 |
|
salicylate synthase;
Pssm-ID: 169151 [Multi-domain] Cd Length: 449 Bit Score: 114.89 E-value: 8.81e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 233 YEQLREVNPSPQMYYVKFGEQKLIGASPELLFRLRQ-GEMETFPLAGTTKRGANEVEDTQfART-LLNDPKEIAEHNMIV 310
Cdd:PRK07912 223 YRLGRRHNTPVRSFLLRLGGIRALGYSPELVTAVRAdGVVITEPLAGTRAFGRGAAIDRL-ARDdLESNSKEIVEHAISV 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 311 DLHRNDIGRVARFGTVKVRSLMDIKRFSHVQHISSEIVGIISEDHDMFSALASNFPAGTLTGAPKIEAMKIIDDLESDGR 390
Cdd:PRK07912 302 RSSLAEITEIAEPGSAAVIDFMTVRERGSVQHLGSTVRGRLDASSDRMDALEALFPAVTASGIPKAAGVDAIFRLDEAPR 381
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 2197122856 391 GPYGGAVGHFSFNGDCTFAIPIRTVFANGENAYVQTCGGNVYDSNPEDEYEEIRRKFA 448
Cdd:PRK07912 382 GLYSGAVVMLSADGGLDAALTLRAAYQVGGRTWLRAGAGIIEESEPEREFEETCEKLS 439
|
|
| PRK06772 |
PRK06772 |
salicylate synthase; |
237-448 |
1.07e-24 |
|
salicylate synthase;
Pssm-ID: 102546 [Multi-domain] Cd Length: 434 Bit Score: 105.97 E-value: 1.07e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 237 REVNPSPQMYYVKFGEQKLIGASPELLFRLRQGEMETFPLAGTTKRGANEVEDTQFARTLLNDPKEIAEHNMIVDLHRND 316
Cdd:PRK06772 216 RQANTPVRSFMFRQEGREALGFSPELVMSVTGNKVVTEPLAGTRDRMGNPEHNKAKEAELLHDSKEVLEHILSVKEAIAE 295
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 317 IGRVARFGTVKVRSLMDIKRFSHVQHISSEIVGIISEDHDMFSALASNFPAGTLTGAPKIEAMKIIDDLESDGRGPYGGA 396
Cdd:PRK06772 296 LEAVCQPGSVVVEDLMSVRQRGSVQHLGSGVSGQLAENKDAWDAFTVLFPSITASGIPKNAALNAIMQIEKTPRELYSGA 375
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 2197122856 397 VGHFSfngDCTF--AIPIRTVFANGENAYVQTCGGNVYDSNPEDEYEEIRRKFA 448
Cdd:PRK06772 376 ILLLD---DTRFdaALVLRSVFQDSQRCWIQAGAGIIAQSTPERELTETREKLA 426
|
|
| PLN02786 |
PLN02786 |
isochorismate synthase |
256-458 |
1.97e-22 |
|
isochorismate synthase
Pssm-ID: 178383 [Multi-domain] Cd Length: 533 Bit Score: 99.86 E-value: 1.97e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 256 IGASPELLFRLRQGEMETFPLAGTTKRGANEVEDTQFARTLLNDPKEIAEHNMIVDLHRNDIGRVARfgTVKVRSLMDIK 335
Cdd:PLN02786 327 IGNTPEQLFHRKGLGVCSEALAATRPRGGSSARDLQIELDLLTSPKDDLEFSIVRENIREKLEAICD--RVVVEPHKAIR 404
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 336 RFSHVQHISSEIVGIISEDHDMFSALASNFPAGTLTGAPKIEAMKIIDDLESDGRGPYGGAVGHFSfNGDCTFAIPIRTV 415
Cdd:PLN02786 405 KLARVQHLYAQLAGRLRSEDDEFDILAALHPTPAVCGHPTEEARLLIAETESFDRGMYAGPVGWFG-GGESEFAVGIRSA 483
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 2197122856 416 FA-NGENAYVQTCGGNVYDSNPEDEYEEIRRK---FAGTKKVLDQFI 458
Cdd:PLN02786 484 LVeKGLGALIYAGTGIVEGSNPSSEWNELELKisqFTKSLEHESALS 530
|
|
| PRK06923 |
PRK06923 |
isochorismate synthase DhbC; Validated |
255-447 |
1.92e-15 |
|
isochorismate synthase DhbC; Validated
Pssm-ID: 235886 [Multi-domain] Cd Length: 399 Bit Score: 77.85 E-value: 1.92e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 255 LIGASPELLFRLRQGEMETFPLAGTTKRGANEVEDTQFARTLLNDPKEIAEHNMIVDlhrndigRVARFGTVKVRSLMDI 334
Cdd:PRK06923 191 LIGASPELLVSRHGMQVISNPLAGSRPRSDDPVEDKRRAEELLSSPKDLHEHAVVVE-------AVAAALRPYCHTLHVP 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 335 KRFSHVQ-----HISSEIVGIIsEDHDMFS-ALASNF-PAGTLTGAPKIEAMKIIDDLESDGRGPYGGAVGHFSFNGDCT 407
Cdd:PRK06923 264 EKPSVIHteamwHLSTEVKGEL-KDPNTSSlELAIALhPTPAVCGTPTEEAREAIQQIEPFDREFFTGMLGWSDLNGDGE 342
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 2197122856 408 FAIPIRTVFANgENAYVQTCG-GNVYDSNPEDEYEEIRRKF 447
Cdd:PRK06923 343 WIVTIRCAEVE-ENTLRLYAGaGVVAESKPEDELAETSAKF 382
|
|
| PRK15016 |
PRK15016 |
isochorismate synthase EntC; Provisional |
228-442 |
7.32e-11 |
|
isochorismate synthase EntC; Provisional
Pssm-ID: 184977 [Multi-domain] Cd Length: 391 Bit Score: 63.74 E-value: 7.32e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 228 DTINLYEQLREVNPSPQMYYVKFGEQK-LIGASPELLFRLRQGEMETFPLAGTTKRGANEVEDTQFARTLLNDPKEIAEH 306
Cdd:PRK15016 163 DSGALLERLIAQNPVSYNFHVPLADGGvLLGASPELLLRKDGERFSSLPLAGSARRQPDEVLDREAGNRLLASEKDRHEH 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 307 NMIVDLHRNDIGRvaRFGTVKVRSLMDIKRFSHVQHISSEIVGIISEDHDMFSALASNFPAGTLTGAPKIEAMKIIDDLE 386
Cdd:PRK15016 243 ELVTQAMKEVLRE--RSSELHVPSSPQLITTPTLWHLATPFEGKANAQENALTLACLLHPTPALSGFPHQAAKQVIAELE 320
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 2197122856 387 SDGRGPYGGAVGHFSFNGDCTFAIPIRTVFANGENAYVQTCGGNVYDSNPEDEYEE 442
Cdd:PRK15016 321 PFDRELFGGIVGWCDSEGNGEWVVTIRCAKLRENQVRLFAGAGIVPASSPLGEWRE 376
|
|
| Anth_synt_I_N |
pfam04715 |
Anthranilate synthase component I, N terminal region; Anthranilate synthase (EC:4.1.3.27) ... |
22-155 |
8.65e-10 |
|
Anthranilate synthase component I, N terminal region; Anthranilate synthase (EC:4.1.3.27) catalyzes the first step in the biosynthesis of tryptophan. Component I catalyzes the formation of anthranilate using ammonia and chorismate. The catalytic site lies in the adjacent region, described in the chorismate binding enzyme family (pfam00425). This region is involved in feedback inhibition by tryptophan. This family also contains a region of Para-aminobenzoate synthase component I (EC 4.1.3.-).
Pssm-ID: 428082 [Multi-domain] Cd Length: 140 Bit Score: 56.93 E-value: 8.65e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 22 DIDFFGLFKKIEKRfDNCFMLESLGEEShiSRHSIIGFDPEQILWATEGELHVQGRDGAVNSYaSDNPYYLLREI----- 96
Cdd:pfam04715 2 LLTPLSVYLKLAGE-PHSFLLESAEGGE--GRYSFIGINPLLTIKSKNGEVSVSGPDGQELEQ-EDGPLDALRALlarfr 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2197122856 97 -VPQNIISRKYAGGLTGYIGYDCMNYFEPSLKLQHSDM-FDVFRFGVFKDGLILDKMTGEV 155
Cdd:pfam04715 78 iEDSPPTLPPFSGGLVGYLGYDLVRYIEKLPRTAPDDLnLPDARLILYEDLIVFDHQENKL 138
|
|
| PRK15012 |
PRK15012 |
menaquinone-specific isochorismate synthase; Provisional |
237-454 |
2.32e-09 |
|
menaquinone-specific isochorismate synthase; Provisional
Pssm-ID: 184974 [Multi-domain] Cd Length: 431 Bit Score: 59.09 E-value: 2.32e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 237 REVNPSPQMYYVKF-GEQKLIGASPELLFRLRQGEMETFPLAGTTKRGANEVEDTQFARTLLNDPKEIAEHNMIVDlhrn 315
Cdd:PRK15012 215 RRLNLNCYHFYMAFdAENAFLGSSPERLWRRRDKALRTEALAGTVANHPDDKQAQQLGEWLMADDKNQRENMLVVE---- 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 316 DIGRVARFGTVKVRSL-MDIKRFSHVQHISSEIVGIISEDHDMFSALASNfPAGTLTGAPKIEAMKIIDDLESDGRGPYG 394
Cdd:PRK15012 291 DICQRLQADTQTLDVLpPQVLRLRKVQHLRRCIWTSLNKADDVICLHQLQ-PTAAVAGLPRDLARQFIARHEPFTREWYA 369
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197122856 395 GAVGHFSFNgDCTFAIPIRTVFANGENAYVQTCGGNVYDSNPEDEYEEIRRKFAGTKKVL 454
Cdd:PRK15012 370 GSAGYLSLQ-QSEFCVSLRSAKVSGNVVRLYAGAGIVRGSDPEQEWQEIDNKAAGLRTLL 428
|
|
| |
