|
Name |
Accession |
Description |
Interval |
E-value |
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
9-489 |
8.74e-114 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 345.62 E-value: 8.74e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 9 LYSWIILVVLVIIVITANSFYVVSTLNDLSALEARLFTTNRVINAVNRLHVAVLRVESGQRGYMLTGDEEYLTDYTETLS 88
Cdd:COG4251 51 LLLLLLSLLALLLLLLLLLLLLLVLAALALLLLLLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLL 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 89 SLGELMDEVEVSSFSSDIEGQTNRIENFLSLTKAKVNEVIEVVELYKEGKEQQAIILVNSDKGLKLYKQFEALFREIDGS 168
Cdd:COG4251 131 LLALLLLEELALLRLALALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELL 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 169 EQDMQGThlanlmslRRDSVNTLIISSATTLLLIITVFLLLKINSREHEKYQADLESVNEDLESRIADRTQELsvysdel 248
Cdd:COG4251 211 LLLEAEL--------LLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEELEERTAEL------- 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 249 ARSNRELEDFAFVASHDLQEPLRKIRAFGNRLESGYNDVIDERGKDYLARMLNAAERMSMLISDLLAFSRVSTRGKEFDD 328
Cdd:COG4251 276 ERSNEELEQFAYVASHDLREPLRKISGFSQLLEEDYGDKLDEEGREYLERIRDAAERMQALIDDLLAYSRVGRQELEFEP 355
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 329 VNLGTVVDSIMGDLEIAIDEKSAQINVSDMPTIRGDKSQLEQLFLNLVSNALKFQSEGVRPEVTISARDATeeetkdill 408
Cdd:COG4251 356 VDLNELLEEVLEDLEPRIEERGAEIEVGPLPTVRGDPTLLRQVFQNLISNAIKYSRPGEPPRIEIGAEREG--------- 426
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 409 aeeyDWTKITVSDNGIGFEQSFAEKIFAPFQRLHGRSEYKGTGIGLAVCRRIVERHNGQITAVSSPGKGATFSIIIPKNS 488
Cdd:COG4251 427 ----GEWVFSVRDNGIGIDPEYAEKIFEIFQRLHSRDEYEGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLPKAP 502
|
.
gi 2197376254 489 E 489
Cdd:COG4251 503 A 503
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
160-487 |
1.40e-58 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 196.67 E-value: 1.40e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 160 ALFREIDGSEQDMQGTHLANLMSLRRDSVNTLIISSATTLLLIITVFLLLKINSREHEKYQADLESVNEDLESRIADRTQ 239
Cdd:COG0642 15 LLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 240 ELSVYSDELARSNRELEDFAFVASHDLQEPLRKIRAFGNRLESGyndvIDERGKDYLARMLNAAERMSMLISDLLAFSRV 319
Cdd:COG0642 95 LLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEE----LDEEQREYLETILRSADRLLRLINDLLDLSRL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 320 STRGK--EFDDVNLGTVVDSIMGDLEIAIDEKSAQINV---SDMPTIRGDKSQLEQLFLNLVSNALKFQSEGVRpeVTIS 394
Cdd:COG0642 171 EAGKLelEPEPVDLAELLEEVVELFRPLAEEKGIELELdlpDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEGGT--VTVS 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 395 ARdateeetkdillaEEYDWTKITVSDNGIGFEQSFAEKIFAPFQRLHGRSEYKGTGIGLAVCRRIVERHNGQITAVSSP 474
Cdd:COG0642 249 VR-------------REGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGGGTGLGLAIVKRIVELHGGTIEVESEP 315
|
330
....*....|...
gi 2197376254 475 GKGATFSIIIPKN 487
Cdd:COG0642 316 GKGTTFTVTLPLA 328
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
246-489 |
2.92e-57 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 190.12 E-value: 2.92e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 246 DELARSNRELEDFAFVASHDLQEPLRKIRAFGNRLESgYNDVIDERGKDYLARMLNAAERMSMLISDLLAFSRVSTRGKE 325
Cdd:COG2205 7 EELEELERLKSEFLANVSHELRTPLTSILGAAELLLD-EEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLESGKLS 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 326 FD--DVNLGTVVDSIMGDLEIAIDEKSAQINVS---DMPTIRGDKSQLEQLFLNLVSNALKFQSEGVRpeVTISARdate 400
Cdd:COG2205 86 LElePVDLAELLEEAVEELRPLAEEKGIRLELDlppELPLVYADPELLEQVLANLLDNAIKYSPPGGT--ITISAR---- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 401 eetkdillaEEYDWTKITVSDNGIGFEQSFAEKIFAPFQRLHGRSEYKGTGIGLAVCRRIVERHNGQITAVSSPGKGATF 480
Cdd:COG2205 160 ---------REGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTF 230
|
....*....
gi 2197376254 481 SIIIPKNSE 489
Cdd:COG2205 231 TVTLPLAES 239
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
112-489 |
2.49e-52 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 182.06 E-value: 2.49e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 112 RIENFLSLTKAKVNEVIEVVELYKEGKEQQAIILVNSDKGLKLYKQFEALFREIDGSEQDMQGTHLANLMSLRRDSVNTL 191
Cdd:COG5002 20 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 192 IISSATTLLLIITVFLLLKINSREHEKYQADLESVNEDLESRIADRTQELSVYSD--ELARSNRELEDFAFVASHDLQEP 269
Cdd:COG5002 100 ALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDitELERLEQMRREFVANVSHELRTP 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 270 LRKIRAFGNRLESGYNDVIDERgKDYLARMLNAAERMSMLISDLLAFSRVSTRGKEFD--DVNLGTVVDSIMGDLEIAID 347
Cdd:COG5002 180 LTSIRGYLELLLDGAADDPEER-REYLEIILEEAERLSRLVNDLLDLSRLESGELKLEkePVDLAELLEEVVEELRPLAE 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 348 EKSAQINV---SDMPTIRGDKSQLEQLFLNLVSNALKFQSEGvrPEVTISARdateeetkdillaEEYDWTKITVSDNGI 424
Cdd:COG5002 259 EKGIELELdlpEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEG--GTITVSLR-------------EEDDQVRISVRDTGI 323
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2197376254 425 GFEQSFAEKIFAPFQRL-HGRS-EYKGTGIGLAVCRRIVERHNGQITAVSSPGKGATFSIIIPKNSE 489
Cdd:COG5002 324 GIPEEDLPRIFERFYRVdKSRSrETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPLARE 390
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
158-485 |
1.36e-44 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 160.35 E-value: 1.36e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 158 FEALFREIDGSEQDMQGTHLANLMSLRRDSVNTLIISSATTLLLIITVFLLLKINSREHEKYQADLESVNEDLESRIadR 237
Cdd:COG4191 51 LLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLLLLLEALLLLLLAALDAEENAELEELERDITELERAEEELR--E 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 238 TQElsvysdELARSNR-----ELedfafVAS--HDLQEPLRKIRAFGNRLESGYNDVID-ERGKDYLARMLNAAERMSML 309
Cdd:COG4191 129 LQE------QLVQSEKlaalgEL-----AAGiaHEINNPLAAILGNAELLRRRLEDEPDpEELREALERILEGAERAAEI 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 310 ISDLLAFSRVSTRGKEfdDVNLGTVVDSIMGDLEIAIDEKSAQINV---SDMPTIRGDKSQLEQLFLNLVSNALKFQSEG 386
Cdd:COG4191 198 VRSLRAFSRRDEEERE--PVDLNELIDEALELLRPRLKARGIEVELdlpPDLPPVLGDPGQLEQVLLNLLINAIDAMEEG 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 387 VRPEVTISARdateeetkdillaEEYDWTKITVSDNGIGFEQSFAEKIFAPFqrlhgRSEYKGTGIGLAVCRRIVERHNG 466
Cdd:COG4191 276 EGGRITISTR-------------REGDYVVISVRDNGPGIPPEVLERIFEPFft--tKPVGKGTGLGLSISYGIVEKHGG 340
|
330
....*....|....*....
gi 2197376254 467 QITAVSSPGKGATFSIIIP 485
Cdd:COG4191 341 RIEVESEPGGGTTFTITLP 359
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
368-485 |
2.59e-39 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 138.23 E-value: 2.59e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 368 LEQLFLNLVSNALKFQSEGVRPEVTISARDATEEetkdillaeeydWTkITVSDNGIGFEQSFAEKIFAPFQRLHGRSEY 447
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRRPPRIEVGAEDVGEE------------WT-FYVRDNGIGIDPEYAEKVFGIFQRLHSREEY 67
|
90 100 110
....*....|....*....|....*....|....*...
gi 2197376254 448 KGTGIGLAVCRRIVERHNGQITAVSSPGKGATFSIIIP 485
Cdd:cd16921 68 EGTGVGLAIVRKIIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
247-490 |
2.16e-38 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 145.10 E-value: 2.16e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 247 ELARSNRE--LEDFAFVASHDLQEPLRKIRAFGNRLESGYNDVI---DERGKDYLARMLNAAERMSMLISDLLAFSRVST 321
Cdd:COG5000 191 ELLRAERLaaWGELARRIAHEIKNPLTPIQLSAERLRRKLADKLeedREDLERALDTIIRQVDRLKRIVDEFLDFARLPE 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 322 RgkEFDDVNLGTVVDSIMGDLEIAIDEKSAQINVS---DMPTIRGDKSQLEQLFLNLVSNALKFQSEGvrPEVTISARda 398
Cdd:COG5000 271 P--QLEPVDLNELLREVLALYEPALKEKDIRLELDldpDLPEVLADRDQLEQVLINLLKNAIEAIEEG--GEIEVSTR-- 344
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 399 teeetkdillaEEYDWTKITVSDNGIGFEQSFAEKIFAPFqrlhgrseY----KGTGIGLAVCRRIVERHNGQITAVSSP 474
Cdd:COG5000 345 -----------REDGRVRIEVSDNGPGIPEEVLERIFEPF--------FttkpKGTGLGLAIVKKIVEEHGGTIELESRP 405
|
250
....*....|....*.
gi 2197376254 475 GKGATFSIIIPKNSEP 490
Cdd:COG5000 406 GGGTTFTIRLPLAEEA 421
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
247-489 |
2.26e-38 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 143.45 E-value: 2.26e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 247 ELARSNRELedFAFVAsHDLQEPLRKIRAFGNRLESgynDVIDERGKDYLARMLNAAERMSMLISDLLAFSRVSTRgkEF 326
Cdd:COG3852 130 EKLAAVGEL--AAGLA-HEIRNPLTGIRGAAQLLER---ELPDDELREYTQLIIEEADRLNNLVDRLLSFSRPRPP--ER 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 327 DDVNLGTVVDSImgdLEIAIDEKSAQINV-----SDMPTIRGDKSQLEQLFLNLVSNALkfQSEGVRPEVTISARDATEE 401
Cdd:COG3852 202 EPVNLHEVLERV---LELLRAEAPKNIRIvrdydPSLPEVLGDPDQLIQVLLNLVRNAA--EAMPEGGTITIRTRVERQV 276
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 402 EtkdILLAEEYDWTKITVSDNGIGFEQSFAEKIFAPFQRlhGRSeyKGTGIGLAVCRRIVERHNGQITAVSSPGKGATFS 481
Cdd:COG3852 277 T---LGGLRPRLYVRIEVIDNGPGIPEEILDRIFEPFFT--TKE--KGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFR 349
|
....*...
gi 2197376254 482 IIIPKNSE 489
Cdd:COG3852 350 IYLPLEQA 357
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
218-485 |
3.44e-34 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 132.38 E-value: 3.44e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 218 KYQADLESVN---EDLESRIAD---RTQELSVYSDELARSNRELEDF-----------AFVAsHDLQEPLRKIRAFGNRL 280
Cdd:PRK09303 98 RWQQEGATYSglgENLQPSEIDsgrYSQELLQLSDELFVLRQENETLleqlkfkdrvlAMLA-HDLRTPLTAASLALETL 176
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 281 ESGYNDVIDERGKDYLARMLNAAER----MSMLISDLLAFSRvsTRGKEFD----DVNLGTVVDSIMGDLEIAIDEKSAQ 352
Cdd:PRK09303 177 ELGQIDEDTELKPALIEQLQDQARRqleeIERLITDLLEVGR--TRWEALRfnpqKLDLGSLCQEVILELEKRWLAKSLE 254
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 353 INV---SDMPTIRGDKSQLEQLFLNLVSNALKFQSEGvrPEVTISARDATEEetkdillaeeydWTKITVSDNGIGFEQS 429
Cdd:PRK09303 255 IQTdipSDLPSVYADQERIRQVLLNLLDNAIKYTPEG--GTITLSMLHRTTQ------------KVQVSICDTGPGIPEE 320
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 2197376254 430 FAEKIFAPFQRLHgRSEYK-GTGIGLAVCRRIVERHNGQITAVSSPGKGATFSIIIP 485
Cdd:PRK09303 321 EQERIFEDRVRLP-RDEGTeGYGIGLSVCRRIVRVHYGQIWVDSEPGQGSCFHFTLP 376
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
363-486 |
5.30e-31 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 115.82 E-value: 5.30e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 363 GDKSQLEQLFLNLVSNALKFQSEGVRPEVTISARDateeetkdillaeeyDWTKITVSDNGIGFEQSFAEKIFAPFQRLH 442
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDG---------------DHVEITVEDNGPGIPPEDLEKIFEPFFRTD 65
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 2197376254 443 GRS-EYKGTGIGLAVCRRIVERHNGQITAVSSPGKGATFSIIIPK 486
Cdd:smart00387 66 KRSrKIGGTGLGLSIVKKLVELHGGEISVESEPGGGTTFTITLPL 110
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
237-495 |
9.44e-31 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 124.70 E-value: 9.44e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 237 RTQELSVYSDELARsnreLEDFAFVASHDLQEPLRKIRAFGNRLEsgynDVIDERGKDYLARMLNAAERMSMLISDLLAF 316
Cdd:COG5809 256 KLEELLRKSEKLSV----VGELAAGIAHEIRNPLTSLKGFIQLLK----DTIDEEQKTYLDIMLSELDRIESIISEFLVL 327
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 317 SRvsTRGKEFDDVNLGTVVDSIMGDLEIAIDEKSAQI---NVSDMPTIRGDKSQLEQLFLNLVSNALKFQSEGVrpEVTI 393
Cdd:COG5809 328 AK--PQAIKYEPKDLNTLIEEVIPLLQPQALLKNVQIeleLEDDIPDILGDENQLKQVFINLLKNAIEAMPEGG--NITI 403
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 394 SARdateeetkdillAEEYDWTKITVSDNGIGFEQSFAEKIFAPFQRlhgrSEYKGTGIGLAVCRRIVERHNGQITAVSS 473
Cdd:COG5809 404 ETK------------AEDDDKVVISVTDEGCGIPEERLKKLGEPFYT----TKEKGTGLGLMVSYKIIEEHGGKITVESE 467
|
250 260
....*....|....*....|..
gi 2197376254 474 PGKGATFSIIIPKNSEPFGSNN 495
Cdd:COG5809 468 VGKGTTFSITLPIKLSEQVSMN 489
|
|
| KinC |
COG5807 |
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ... |
263-485 |
7.91e-30 |
|
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444509 [Multi-domain] Cd Length: 358 Bit Score: 119.89 E-value: 7.91e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 263 SHDLQEPLRKIRAFgnrLESGYNDVIDERGKDYLARMLNAAERMSMLISDLLAFSRvsTRGKEFDDVNLGTVVDSIMGDL 342
Cdd:COG5807 155 AHEIRNPLTSIKGF---LQLLQESREDSEREEYFNIIISEIDRINTIITELLVLSK--PKKFNFKKLNLNDVLEDVIALL 229
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 343 EIAIDEKSAQINVS---DMPTIRGDKSQLEQLFLNLVSNALKFQSEGvrPEVTISARDateeetkdillaeEYDWTKITV 419
Cdd:COG5807 230 STEAILKNISIKYDladDEPVINGDKNQLKQVFINLIKNAIEAMETG--GNITIKTYV-------------EGDFVVISV 294
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2197376254 420 SDNGIGFEQSFAEKIFAPFQRLHGrseyKGTGIGLAVCRRIVERHNGQITAVSSPGKGATFSIIIP 485
Cdd:COG5807 295 KDEGIGIPEEVLEKIGEPFFTTKE----EGTGLGLSICKKIIEEHNGTIEVESKPGKGTTFTIYLP 356
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
368-485 |
1.36e-29 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 111.82 E-value: 1.36e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 368 LEQLFLNLVSNALKFQSEGvrpEVTISARDATEEETKDILlaeeydwtKITVSDNGIGFEQSFAEKIFAPFQRL--HGRS 445
Cdd:cd16922 1 LRQILLNLLGNAIKFTEEG---EVTLRVSLEEEEEDGVQL--------RFSVEDTGIGIPEEQQARLFEPFSQAdsSTTR 69
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 2197376254 446 EYKGTGIGLAVCRRIVERHNGQITAVSSPGKGATFSIIIP 485
Cdd:cd16922 70 KYGGTGLGLAISKKLVELMGGDISVESEPGQGSTFTFTLP 109
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
363-485 |
6.81e-28 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 107.07 E-value: 6.81e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 363 GDKSQLEQLFLNLVSNALKFQSEGVRPEVTIsardateeetkdillaEEYDWTKITVSDNGIGFEQSFAEKIFAPFQRLH 442
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVTL----------------SEGGELTLTVEDNGIGIPPEDLPRIFEPFSTAD 64
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 2197376254 443 GRSeYKGTGIGLAVCRRIVERHNGQITAVSSPGKGATFSIIIP 485
Cdd:pfam02518 65 KRG-GGGTGLGLSIVRKLVELLGGTITVESEPGGGTTVTLTLP 106
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
264-486 |
4.86e-27 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 114.06 E-value: 4.86e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 264 HDLQEPLRKIRAFGNRLESGyndviDERGKDYLARMLNAAERMSMLISDLLAFSRVSTRGKEFDDVN--LGTVV-----D 336
Cdd:COG5805 296 HEIRNPLTSIKGFLQLLQPG-----IEDKEEYFDIMLSELDRIESIISEFLALAKPQAVNKEKENINelIQDVVtlletE 370
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 337 SIMGDLEIAIDEKSaqinvsDMPTIRGDKSQLEQLFLNLVSNALkfqsegvrpevtisarDATEEETK-DILLAEEYDWT 415
Cdd:COG5805 371 AILHNIQIRLELLD------EDPFIYCDENQIKQVFINLIKNAI----------------EAMPNGGTiTIHTEEEDNSV 428
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2197376254 416 KITVSDNGIGFEQSFAEKIFAPFQRLhgrsEYKGTGIGLAVCRRIVERHNGQITAVSSPGKGATFSIIIPK 486
Cdd:COG5805 429 IIRVIDEGIGIPEERLKKLGEPFFTT----KEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLPL 495
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
236-489 |
1.66e-25 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 110.06 E-value: 1.66e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 236 DRTqELSVYSDELARSNR-----ELedFAFVAsHDLQEPLRKIRAFGNRLESGYNDVIDERgkdYLARMLNAAERMSMLI 310
Cdd:PRK11360 370 DLT-ERKRLQRRVARQERlaalgEL--VAGVA-HEIRNPLTAIRGYVQIWRQQTSDPPSQE---YLSVVLREVDRLNKVI 442
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 311 SDLLAFSRvsTRGKEFDDVNLGTVVDSIMGDLEIAidEKSAQINV-----SDMPTIRGDKSQLEQLFLNLVSNALkfQSE 385
Cdd:PRK11360 443 DQLLEFSR--PRESQWQPVSLNALVEEVLQLFQTA--GVQARVDFeteldNELPPIWADPELLKQVLLNILINAV--QAI 516
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 386 GVRPEVTISardaTEEETKDILLaeeydwtkITVSDNGIGFEQSFAEKIFAPFQRlhgrSEYKGTGIGLAVCRRIVERHN 465
Cdd:PRK11360 517 SARGKIRIR----TWQYSDGQVA--------VSIEDNGCGIDPELLKKIFDPFFT----TKAKGTGLGLALSQRIINAHG 580
|
250 260
....*....|....*....|....
gi 2197376254 466 GQITAVSSPGKGATFSIIIPKNSE 489
Cdd:PRK11360 581 GDIEVESEPGVGTTFTLYLPINPQ 604
|
|
| HK9-like_sensor |
cd19410 |
ligand binding sensor domain of Rhodopseudomonas palustris histidine kinase HK9 and similar ... |
47-171 |
1.02e-23 |
|
ligand binding sensor domain of Rhodopseudomonas palustris histidine kinase HK9 and similar proteins; The ligand binding sensor domain of Rhodopseudomonas palustris histidine kinase HK9 and similar proteins forms a homodimer and binds to an as yet uncharacterized ligand, most likely via the dimerization interface, a feature that appears to be conserved in this domain superfamily. This domain is similar to the extracellular sensory domain CHASE3, specifically found in histidine kinases, adenylate cyclases, methyl-accepting chemotaxis proteins and predicted diguanylate cyclases/phosphodiesterases. Environmental factors that are recognized by CHASE3 domains are not known at this time.
Pssm-ID: 438628 Cd Length: 125 Bit Score: 96.12 E-value: 1.02e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 47 TNRVINAVNRLHVAVLRVESGQRGYMLTGDEEYLTDYTETLSSLGELMDEVEvsSFSSDIEGQTNRIENFLSLTKAKVNE 126
Cdd:cd19410 3 TYEVLSELERLLSLLKDAETGQRGYLLTGDESYLEPYNAARARLPALLAELR--ELTADNPAQQARLDELEPLIDEKLAE 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 2197376254 127 VIEVVELYKEGKEQQAIILVNSDKGLKLYKQFEALFREIDGSEQD 171
Cdd:cd19410 81 LARTIELRRAGGFEAALALVRSGRGKRLMDEIRALIAEMIAEERR 125
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
152-489 |
4.98e-23 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 101.79 E-value: 4.98e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 152 LKLYKQFEALFREIDGSEQDMQGTHLAN--------------LMSLRRDSVNTLIISSATTLLLIITVFLLLkinsrEHE 217
Cdd:PRK10364 141 LEIYRQFQPMFAAGMHGMRHMQQYAAANtpqaifiafdasnlVSAQAREQRNTLIILFALATVLLASLLAFF-----WYR 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 218 KYqadlesvnedLESRiadrtQELSvysDELARSNR--ELEDFAFVASHDLQEPLRKIRA----FGNRLESGyndvider 291
Cdd:PRK10364 216 RY----------LRSR-----QLLQ---DEMKRKEKlvALGHLAAGVAHEIRNPLSSIKGlakyFAERAPAG-------- 269
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 292 GKDY-LAR-MLNAAERMSMLISDLLAFSRVStrgkefdDVNLGTVV--DSIMGDLE-IAIDEKSAQINV-----SDMPTI 361
Cdd:PRK10364 270 GEAHqLAQvMAKEADRLNRVVSELLELVKPT-------HLALQAVDlnDLINHSLQlVSQDANSREIQLrftanDTLPEI 342
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 362 RGDKSQLEQLFLNLVSNALKFQSEGVRPEVTISARDateeetkdillaeeyDWTKITVSDNGIGFEQSFAEKIFAPFQRL 441
Cdd:PRK10364 343 QADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESG---------------AGVKISVTDSGKGIAADQLEAIFTPYFTT 407
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 2197376254 442 HGrseyKGTGIGLAVCRRIVERHNGQITAVSSPGKGATFSIIIPKNSE 489
Cdd:PRK10364 408 KA----EGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPVNIT 451
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
245-490 |
1.95e-21 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 98.18 E-value: 1.95e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 245 SDELARSNRELEDF--AFVA--SHDLQEPLRKIraFGnRLESGYNDVIDERGKDylARMLNAAER----MSMLISDLLAF 316
Cdd:PRK10490 650 SEEQARLASEREQLrnALLAalSHDLRTPLTVL--FG-QAEILTLDLASEGSPH--ARQASEIRQqvlnTTRLVNNLLDM 724
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 317 SRVSTRG----KEFddVNLGTVVDSIMGDLEIAIDEKSAQINVS-DMPTIRGDKSQLEQLFLNLVSNALKFQseGVRPEV 391
Cdd:PRK10490 725 ARIQSGGfnlrKEW--LTLEEVVGSALQMLEPGLSGHPINLSLPePLTLIHVDGPLFERVLINLLENAVKYA--GAQAEI 800
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 392 TISARdateeetkdillaEEYDWTKITVSDNGIGFEQSFAEKIFAPFQRLHGRSEYKGTGIGLAVCRRIVERHNGQITAV 471
Cdd:PRK10490 801 GIDAH-------------VEGERLQLDVWDNGPGIPPGQEQLIFDKFARGNKESAIPGVGLGLAICRAIVEVHGGTIWAE 867
|
250
....*....|....*....
gi 2197376254 472 SSPGKGATFSIIIPKNSEP 490
Cdd:PRK10490 868 NRPEGGACFRVTLPLETPP 886
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
291-490 |
2.38e-20 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 94.74 E-value: 2.38e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 291 RGKDYLARMLNAAERMSMLISDLLAFSRVSTRGKEfdDVNLGTVVD--------SIMGDLEIAIDEKSAQINVSdmptir 362
Cdd:PRK13837 484 RAARYIDEIISAGARARLIIDQILAFGRKGERNTK--PFDLSELVTeiapllrvSLPPGVELDFDQDQEPAVVE------ 555
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 363 GDKSQLEQLFLNLVSNALKFQSEGVRPEVTISARD--ATEEETKDILLAEEYdwTKITVSDNGIGFEQSFAEKIFAPFqr 440
Cdd:PRK13837 556 GNPAELQQVLMNLCSNAAQAMDGAGRVDISLSRAKlrAPKVLSHGVLPPGRY--VLLRVSDTGAGIDEAVLPHIFEPF-- 631
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 2197376254 441 LHGRSeyKGTGIGLAVCRRIVERHNGQITAVSSPGKGATFSIIIPKNSEP 490
Cdd:PRK13837 632 FTTRA--GGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLPPSSKV 679
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
51-485 |
6.18e-19 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 90.35 E-value: 6.18e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 51 INAVNRLHVAVLRVesgQRGYMLTGDEEYLTDYTETLSSLGELMDEVevSSFSSDIEGQTNRIENFLSLTKakVNEVIEV 130
Cdd:PRK11466 200 VNQMNELRLSALRV---QQMVMNLGLEQIQKNAPTLEKQLNNAVKIL--QRRQIRIEDPGVRAQVATTLTT--VSQYSDL 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 131 VELYKEGKEQQAIILVNSDKGLKLYKQFEA-LFREIDGSEQDMQgTHLANLMSLRRDSVNTLIISSATTLLLIITVF--- 206
Cdd:PRK11466 273 LALYQQDSEISNHLQTLAQNNIAQFAQFSSeVSQLVDTIELRNQ-HGLAHLEKASARGQYSLLLLGMVSLCALILILwrv 351
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 207 ------------------LL----------------LKINSREHEKYQADLESVN---EDLESRIADRTQELS--VYSDE 247
Cdd:PRK11466 352 vyrsvtrplaeqtqalqrLLdgdidspfpetagvreLDTIGRLMDAFRSNVHALNrhrEQLAAQVKARTAELQelVIEHR 431
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 248 LARSNRELEDFA---FVA--SHDLQEPLRKIRAFGNRLEsgyNDVIDERGKDYLARMLNAAERMSMLISDLLAFSRVSTR 322
Cdd:PRK11466 432 QARAEAEKASQAksaFLAamSHEIRTPLYGILGTAQLLA---DNPALNAQRDDLRAITDSGESLLTILNDILDYSAIEAG 508
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 323 GKefdDVNLG-------TVVDSIMGDLEIAIDEKSAQIN---VSDMPT-IRGDKSQLEQLFLNLVSNALKFQSEGVrpev 391
Cdd:PRK11466 509 GK---NVSVSdepfeprPLLESTLQLMSGRVKGRPIRLAtdiADDLPTaLMGDPRRIRQVITNLLSNALRFTDEGS---- 581
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 392 tISARDATEEETkdillaeeydWTkITVSDNGIGFEQSFAEKIFAPFQRLHGRSeyKGTGIGLAVCRRIVERHNGQITAV 471
Cdd:PRK11466 582 -IVLRSRTDGEQ----------WL-VEVEDSGCGIDPAKLAEIFQPFVQVSGKR--GGTGLGLTISSRLAQAMGGELSAT 647
|
490
....*....|....
gi 2197376254 472 SSPGKGATFSIIIP 485
Cdd:PRK11466 648 STPEVGSCFCLRLP 661
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
213-478 |
2.07e-18 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 88.20 E-value: 2.07e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 213 SREHEKYQADLESVNEDLESRIADRTQelsvYSDELARSNRELEDFAFVA---------SHDLQEPLRKIRAFGNRLESG 283
Cdd:COG4192 386 ARLLRVFRDQAIEKTQELETEIEERKR----IEKNLRQTQDELIQAAKMAvvgqtmtslAHELNQPLNAMSMYLFSAKKA 461
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 284 YNDVIDERGKDYLARMLNAAERMSMLISDLLAFSRVSTRgkEFDDVNLGTVVDSIMGDLEIAIDEKSAQINVSDMPTIRG 363
Cdd:COG4192 462 LEQENYAQLPTSLDKIEGLIERMDKIIKSLRQFSRKSDT--PLQPVDLRQVIEQAWELVESRAKPQQITLHIPDDLMVQG 539
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 364 DKSQLEQLFLNLVSNALKFQSEgvRPEVTISArdatEEETKDILLAeeydwtkitVSDNGIGFEqsFAEKIFAPFQrlhg 443
Cdd:COG4192 540 DQVLLEQVLVNLLVNALDAVAT--QPQISVDL----LSNAENLRVA---------ISDNGNGWP--LVDKLFTPFT---- 598
|
250 260 270
....*....|....*....|....*....|....*
gi 2197376254 444 RSEYKGTGIGLAVCRRIVERHNGQITAVSSPGKGA 478
Cdd:COG4192 599 TTKEVGLGLGLSICRSIMQQFGGDLYLASTLERGA 633
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
244-485 |
2.13e-18 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 88.46 E-value: 2.13e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 244 YSDELARSNRELEDFAFVASHDLQEPL-----------------------RKIRAFGNRLESGYNDVID----ERGKDYL 296
Cdd:PRK11091 272 YQDALEKASRDKTTFISTISHELRTPLngivglsrilldteltaeqrkylKTIHVSAITLGNIFNDIIDmdkmERRKLQL 351
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 297 ArmlNAAERMSMLISDLLAFSR--VSTRGKEFDdvnlgtvvdsimgdLEIaideksaqinVSDMP-TIRGDKSQLEQLFL 373
Cdd:PRK11091 352 D---NQPIDFTDFLADLENLSGlqAEQKGLRFD--------------LEP----------LLPLPhKVITDGTRLRQILW 404
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 374 NLVSNALKFQSEGvrpEVTISARdateEETKDILLAEeydwtkitVSDNGIGFEQSFAEKIFAPF---QRLHGRSEYKGT 450
Cdd:PRK11091 405 NLISNAVKFTQQG---GVTVRVR----YEEGDMLTFE--------VEDSGIGIPEDELDKIFAMYyqvKDSHGGKPATGT 469
|
250 260 270
....*....|....*....|....*....|....*
gi 2197376254 451 GIGLAVCRRIVERHNGQITAVSSPGKGATFSIIIP 485
Cdd:PRK11091 470 GIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTIH 504
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
366-485 |
3.27e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 79.77 E-value: 3.27e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 366 SQLEQLFLNLVSNALkfQSEGVRPEVTISARDATEEetkdillaeeydwTKITVSDNGIGFEQSFAEKIFAPF--QRLHG 443
Cdd:cd16943 2 SQLNQVLLNLLVNAA--QAMEGRGRITIRTWAHVDQ-------------VLIEVEDTGSGIDPEILGRIFDPFftTKPVG 66
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 2197376254 444 rseyKGTGIGLAVCRRIVERHNGQITAVSSPGKGATFSIIIP 485
Cdd:cd16943 67 ----EGTGLGLSLSYRIIQKHGGTIRVASVPGGGTRFTIILP 104
|
|
| CHASE3 |
pfam05227 |
CHASE3 domain; CHASE3 is an extracellular sensory domain, which is present in various classes ... |
47-171 |
3.55e-18 |
|
CHASE3 domain; CHASE3 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria. Specifically, CHASE3 domains are found in histidine kinases, adenylate cyclases, methyl-accepting chemotaxis proteins and predicted diguanylate cyclases/phosphodiesterases. This domain recognizes pyrene (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 428379 Cd Length: 138 Bit Score: 80.82 E-value: 3.55e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 47 TNRVINAVNRLHVAVLRVESGQRGYMLTGDEEYLTDYTETLSSLGELMDEVEvsSFSSDIEGQTNRIENFLSLTKAKVNE 126
Cdd:pfam05227 8 TQEVLAALEQLLSALVDAETGQRGYLLTGDESFLEPYEEARAAIPELLARLR--ALTADNPEQQQRLERLEALIEQKLAE 85
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 2197376254 127 VIEVVELYKEGKEQQAIILVNSDKGLKLYKQFEALFREIDGSEQD 171
Cdd:pfam05227 86 LEPTIALRREGGLEAALALVRSDEGKRLMDAIRALLAEMKAEERR 130
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
368-485 |
4.52e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 79.36 E-value: 4.52e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 368 LEQLFLNLVSNALKFQSEGV--RPEVTISardaTEEETKDILlaeeydwtKITVSDNGIGFEQSFAEKIFAPFQRlhgrS 445
Cdd:cd16920 1 IQQVLINLVRNGIEAMSEGGceRRELTIR----TSPADDRAV--------TISVKDTGPGIAEEVAGQLFDPFYT----T 64
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 2197376254 446 EYKGTGIGLAVCRRIVERHNGQITAVSSPGKGATFSIIIP 485
Cdd:cd16920 65 KSEGLGMGLSICRSIIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
360-477 |
1.05e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 78.60 E-value: 1.05e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 360 TIRGDKSQLEQLFLNLVSNALKFQSEGVRPEVTISARDATEeetkdillaeeydwtkITVSDNGIGFEQSFAEKIFAPFQ 439
Cdd:cd16940 6 QVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADDGAV----------------IRVEDNGPGIDEEELEALFERFY 69
|
90 100 110
....*....|....*....|....*....|....*...
gi 2197376254 440 RLHGRSeYKGTGIGLAVCRRIVERHNGQITAVSSPGKG 477
Cdd:cd16940 70 RSDGQN-YGGSGLGLSIVKRIVELHGGQIFLGNAQGGG 106
|
|
| CHASE3 |
COG5278 |
Extracytoplasmic sensor domain CHASE3 (specificity unknown) [Signal transduction mechanisms]; |
25-411 |
1.75e-17 |
|
Extracytoplasmic sensor domain CHASE3 (specificity unknown) [Signal transduction mechanisms];
Pssm-ID: 444089 [Multi-domain] Cd Length: 530 Bit Score: 85.34 E-value: 1.75e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 25 ANSFYVVSTLNDLSALEARLFTTNRVINAVNRLHVAVLRVESGQRGYMLTGDEEYLTDYTETLSSLGELMDEVEvsSFSS 104
Cdd:COG5278 23 VLGVLSYLSLNRLREASEWVEHTYEVLRALEELLSALLDAETGQRGYLLTGDESFLEPYEEARAEIDELLAELR--SLTA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 105 DIEGQTNRIENFLSLTKAKVNEVIEVVELYKEGKEQQAIILVNSDKGLKLYKQFEALFREIDGSEQDMQGTHLANLMSLR 184
Cdd:COG5278 101 DNPEQQARLDELEALIDQWLAELEQVIALRRAGGLEAALALVRSGEGKALMDEIRARLLLLALALAALLLAAAALLLLLL 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 185 RDSVNTLIISSATTLLLIITVFLLLKINSREHEKYQADLESVNEDLESRIADRTQELSVYSDELARSNRELEDFAFVASH 264
Cdd:COG5278 181 ALAALLALAELLLLALARALAALLLLLLLEAELAAAAALLAAAAALAALAALELLAALALALALLLAALLLALLAALALA 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 265 DLQEPLRKIRAFGNRLESGYNDVIDERGKDYLARMLNAAERMSMLISDLLAFSRVSTRGKEFDDVNLGTVVDSIMGDLEI 344
Cdd:COG5278 261 ALLAAALLALAALLLALAAAAALAAAAALELAAAEALALAELELELLLAAAAAAAAAAAAAAAALAALLALALATALAAA 340
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2197376254 345 AIDEKSAQINVSDMPTIRGDKSQLEQLFLNLVSNALKFQSEGVRPEVTISARDATEEETKDILLAEE 411
Cdd:COG5278 341 AAALALLAALLAEAAAAAAEEAEAAAEAAAAALAGLAEVEAEGAAEAVELEVLAIAAAAAAAAAEAA 407
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
199-487 |
5.77e-17 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 84.31 E-value: 5.77e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 199 LLLIITVFLLLKIN--------------------------SREHE------KYQADLESVNE---DLESRIADRTQELSV 243
Cdd:PRK15347 307 VLLTSVLFLLLRRYlakplwrfvdiinktgpaaleprlpeNRLDElgsiakAYNQLLDTLNEqydTLENKVAERTQALAE 386
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 244 YSDELARSNRELEDFAFVASHDLQEPLRKIRAfgnRLESGYNDVIDERGKDYLARMLNAAERMSMLISDLLAFSRVSTRG 323
Cdd:PRK15347 387 AKQRAEQANKRKSEHLTTISHEIRTPLNGVLG---ALELLQNTPLTAEQMDLADTARQCTLSLLAIINNLLDFSRIESGQ 463
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 324 KE--FDDVNLGTVVDSIMGDLEIAIDEKSAQINV---SDMP-TIRGDKSQLEQLFLNLVSNALKFQSEGvrpevTISARD 397
Cdd:PRK15347 464 MTlsLEETALLPLLDQAMLTIQGPAQSKSLTLRTfvgAHVPlYLHLDSLRLRQILVNLLGNAVKFTETG-----GIRLRV 538
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 398 ATEEETkdilLAeeydwtkITVSDNGIGFEQSFAEKIFAPFQRLHGRSeyKGTGIGLAVCRRIVERHNGQITAVSSPGKG 477
Cdd:PRK15347 539 KRHEQQ----LC-------FTVEDTGCGIDIQQQQQIFTPFYQADTHS--QGTGLGLTIASSLAKMMGGELTLFSTPGVG 605
|
330
....*....|
gi 2197376254 478 ATFSIIIPKN 487
Cdd:PRK15347 606 SCFSLVLPLN 615
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
240-486 |
3.98e-16 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 80.66 E-value: 3.98e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 240 ELSVYSDELARSNRELEDFAFVAS------HDLQEPLRKIRAFGNRLESgynDVIDERGKDYLARMLNAAERMSMLISDL 313
Cdd:PRK11100 235 ELRELAQALESMRVKLEGKAYVEQyvqtltHELKSPLAAIRGAAELLQE---DPPPEDRARFTGNILTQSARLQQLIDRL 311
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 314 LAFSRVSTRG--KEFDDVNLGTVVDSIMGDLEIAIDEKSAQINVS-DMPTIRGDKSQLEQLFLNLVSNALKFQSEGVrpE 390
Cdd:PRK11100 312 LELARLEQRQelEVLEPVALAALLEELVEAREAQAAAKGITLRLRpDDARVLGDPFLLRQALGNLLDNAIDFSPEGG--T 389
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 391 VTISARDATEEetkdillaeeydwTKITVSDNGIGFEqSFA-EKIFAPF---QRLHGRSeyKGTGIGLAVCRRIVERHNG 466
Cdd:PRK11100 390 ITLSAEVDGEQ-------------VALSVEDQGPGIP-DYAlPRIFERFyslPRPANGR--KSTGLGLAFVREVARLHGG 453
|
250 260
....*....|....*....|
gi 2197376254 467 QITAVSSPGKGATFSIIIPK 486
Cdd:PRK11100 454 EVTLRNRPEGGVLATLTLPR 473
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
208-485 |
1.33e-14 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 76.70 E-value: 1.33e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 208 LLKINSREHEKYQADLESVNEdlesrIADRTQELSVYSDELARSNRELEDFAFVASHDLQEPLRKIRAFGNRLESgyNDV 287
Cdd:PRK09959 670 LCNLPASDHAVYICGWQDITE-----TRDLIHALEVERNKAINATVAKSQFLATMSHEIRTPISSIMGFLELLSG--SGL 742
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 288 IDERGKDYLARMLNAAERMSMLISDLLAFSRVSTRGKEFDD--VNLGTVVDSIMGDLEIAIDEKSAQINVS----DMPTI 361
Cdd:PRK09959 743 SKEQRVEAISLAYATGQSLLGLIGEILDVDKIESGNYQLQPqwVDIPTLVQNTCHSFGAIAASKSIALSCSstfpDHYLV 822
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 362 RGDKSQLEQLFLNLVSNALKFQSEGvrpevtisardATEEETKDILLAEEYDWTKITVSDNGIGFEQSFAEKIFAPFQRL 441
Cdd:PRK09959 823 KIDPQAFKQVLSNLLSNALKFTTEG-----------AVKITTSLGHIDDNHAVIKMTIMDSGSGLSQEEQQQLFKRYSQT 891
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 2197376254 442 HGRSEYKGTGIGLAVCRRIVERHNGQITAVSSPGKGATFSIIIP 485
Cdd:PRK09959 892 SAGRQQTGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIP 935
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
364-485 |
1.45e-14 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 69.83 E-value: 1.45e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 364 DKSQLEQLFLNLVSNALKFQSEGVRPEVTISARDateeeTKDILLaeeydwtkiTVSDNGIGFEQSFAEKIFAPFQRLHG 443
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEKFR-----LNRFLL---------TVSDSGPGIPPNLREEIFERFRQGDG 66
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 2197376254 444 RSEYK--GTGIGLAVCRRIVERHNGQITAVSSPGKGATFSIIIP 485
Cdd:cd16925 67 SSTRAhgGTGLGLSIVKEFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
341-489 |
1.54e-14 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 75.27 E-value: 1.54e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 341 DLEIAIDeksaqinvSDMPTIRGDKSQLEQLFLNLVSNALK--FQSEGVRPEVTISARDateeeTKDILLaeeydwtkIT 418
Cdd:COG3290 263 DLTIDID--------SDLPDLPLSDTDLVTILGNLLDNAIEavEKLPEEERRVELSIRD-----DGDELV--------IE 321
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2197376254 419 VSDNGIGFEQSFAEKIFAPfqrlhGRS--EYKGTGIGLAVCRRIVERHNGQITAVSSPGKGATFSIIIPKNSE 489
Cdd:COG3290 322 VEDSGPGIPEELLEKIFER-----GFStkLGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKEGE 389
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
374-485 |
1.73e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 69.24 E-value: 1.73e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 374 NLVSNALKFQSEGVRPEVTISardateeetkdILLAEEYDWTKITVSDNGIGFEQSFAEKIFApfqrlHGRS--EYKGTG 451
Cdd:cd16915 7 NLIDNALDALAATGAPNKQVE-----------VFLRDEGDDLVIEVRDTGPGIAPELRDKVFE-----RGVStkGQGERG 70
|
90 100 110
....*....|....*....|....*....|....
gi 2197376254 452 IGLAVCRRIVERHNGQITAVSSPGKGATFSIIIP 485
Cdd:cd16915 71 IGLALVRQSVERLGGSITVESEPGGGTTFSIRIP 104
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
368-486 |
2.49e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 68.89 E-value: 2.49e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 368 LEQLFLNLVSNALKFQSEgvrpevtisardateeetkDILLAEEYD---WTkITVSDNGIGFEQSFAEKIFAPFQRL--H 442
Cdd:cd16949 1 LARALENVLRNALRYSPS-------------------KILLDISQDgdqWT-ITITDDGPGVPEDQLEQIFLPFYRVdsA 60
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 2197376254 443 GRSEYKGTGIGLAVCRRIVERHNGQITAVSSPGKGATFSIIIPK 486
Cdd:cd16949 61 RDRESGGTGLGLAIAERAIEQHGGKIKASNRKPGGLRVRIWLPA 104
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
276-485 |
9.91e-14 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 73.55 E-value: 9.91e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 276 FGNRLE--SGYNDVID---ERGKDYLARML-------NAAERMSMLISDLLAFSRVST-RGKEfddVNLGTVVdSIMGDL 342
Cdd:PRK13557 174 FNNLLQvmSGYLDVIQaalSHPDADRGRMArsvenirAAAERAATLTQQLLAFARKQRlEGRV---LNLNGLV-SGMGEL 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 343 -------EIAIDEKSAqinvSDMPTIRGDKSQLEQLFLNLVSNALKFQSEGVRpeVTISAR--DATEEETK--DILLAEE 411
Cdd:PRK13557 250 aertlgdAVTIETDLA----PDLWNCRIDPTQAEVALLNVLINARDAMPEGGR--VTIRTRnvEIEDEDLAmyHGLPPGR 323
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2197376254 412 YdwTKITVSDNGIGFEQSFAEKIFAPFqrLHGRSEYKGTGIGLAVCRRIVERHNGQITAVSSPGKGATFSIIIP 485
Cdd:PRK13557 324 Y--VSIAVTDTGSGMPPEILARVMDPF--FTTKEEGKGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYFP 393
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
368-484 |
4.63e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 65.17 E-value: 4.63e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 368 LEQLFLNLVSNALKFQSEGVRPEVTISARDATEeetkdillaeeyDWTkITVSDNGIGFEQSFAEKIFAPFqrLHGRSEY 447
Cdd:cd16976 1 IQQVLMNLLQNALDAMGKVENPRIRIAARRLGG------------RLV-LVVRDNGPGIAEEHLSRVFDPF--FTTKPVG 65
|
90 100 110
....*....|....*....|....*....|....*..
gi 2197376254 448 KGTGIGLAVCRRIVERHNGQITAVSSPGKGATFSIII 484
Cdd:cd16976 66 KGTGLGLSISYGIVEEHGGRLSVANEEGAGARFTFDL 102
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
230-486 |
5.00e-13 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 70.81 E-value: 5.00e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 230 LESRIADRT--QELSVYSD-------ELARSNReledFAFVaSHDLQEPLRKIRAFgnrLESGYNDVIDERGKD-YLARM 299
Cdd:PRK11006 175 LEIRVMPYTegQLLMVARDvtqmhqlEGARRNF----FANV-SHELRTPLTVLQGY---LEMMQDQPLEGALREkALHTM 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 300 LNAAERMSMLISDLLAFSRVSTRgkefDDVNLGTVVDSIMGdLEIAidEKSAQ----------INVSDMPTIRGDKSQLE 369
Cdd:PRK11006 247 REQTQRMEGLVKQLLTLSKIEAA----PTIDLNEKVDVPMM-LRVL--EREAQtlsqgkhtitFEVDNSLKVFGNEDQLR 319
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 370 QLFLNLVSNALKFQSEGVRPEVtisardateeetkdillaeeyDWTKI------TVSDNGIGFEQSFAEKIFAPFQRL-H 442
Cdd:PRK11006 320 SAISNLVYNAVNHTPEGTHITV---------------------RWQRVpqgaefSVEDNGPGIAPEHIPRLTERFYRVdK 378
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 2197376254 443 GRS-EYKGTGIGLAVCRRIVERHNGQITAVSSPGKGATFSIIIPK 486
Cdd:PRK11006 379 ARSrQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVLPE 423
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
364-485 |
8.40e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 64.48 E-value: 8.40e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 364 DKSQLEQLFLNLVSNALKF--QSEGVRPEVTISARDATEEetkDILlaeeydwtkITVSDNGIGFEQSFAEKIFAPFQRl 441
Cdd:cd16944 1 DTTQISQVLTNILKNAAEAieGRPSDVGEVRIRVEADQDG---RIV---------LIVCDNGKGFPREMRHRATEPYVT- 67
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 2197376254 442 hgrSEYKGTGIGLAVCRRIVERHNGQITAVSSPGKGATFSIIIP 485
Cdd:cd16944 68 ---TRPKGTGLGLAIVKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
368-485 |
1.22e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 64.32 E-value: 1.22e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 368 LEQLFLNLVSNALKFQSEGVRpeVTISARDATEEETKDILLAE--EYDWTKITVSDNGIGFEQSFAEKIFAPFqrLHGRS 445
Cdd:cd16919 1 LELAILNLAVNARDAMPEGGR--LTIETSNQRVDADYALNYRDliPGNYVCLEVSDTGSGMPAEVLRRAFEPF--FTTKE 76
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 2197376254 446 EYKGTGIGLAVCRRIVERHNGQITAVSSPGKGATFSIIIP 485
Cdd:cd16919 77 VGKGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
368-485 |
1.98e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 63.57 E-value: 1.98e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 368 LEQLFLNLVSNALKfqsegvrpevtisardATEEETKDILLAEEYDWT------------KITVSDNGIGFEQSFAEKIF 435
Cdd:cd16918 1 LIQVFLNLVRNAAQ----------------ALAGSGGEIILRTRTQRQvtlghprhrlalRVSVIDNGPGIPPDLQDTIF 64
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 2197376254 436 APFqrLHGRSEykGTGIGLAVCRRIVERHNGQITAVSSPGKgATFSIIIP 485
Cdd:cd16918 65 YPM--VSGREN--GTGLGLAIAQNIVSQHGGVIECDSQPGH-TVFSVSLP 109
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
368-485 |
2.12e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 63.22 E-value: 2.12e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 368 LEQLFLNLVSNALKFQSEGVRPEVTISArdateeetkdillaeeyDWTKITVSDNGIGFEQSFAEKIFAPFQRLH-GRSE 446
Cdd:cd16939 1 MARALDNLLRNALRYAHRTVRIALLVSG-----------------GRLTLIVEDDGPGIPAAARERVFEPFVRLDpSRDR 63
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 2197376254 447 YK-GTGIGLAVCRRIVERHNGQITAVSSPGKGATFSIIIP 485
Cdd:cd16939 64 ATgGFGLGLAIVHRVALWHGGHVECDDSELGGACFRLTWP 103
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
364-485 |
4.74e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 62.48 E-value: 4.74e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 364 DKSQLEQLFLNLVSNALKFQSEGVRPEVTISARDATeeetkdillaeeydWTkITVSDNGIGFEQSFAEKIFAPFQRLHG 443
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQE--------------VR-LDVEDSAPGVSDDQLARLFERFYRVES 65
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 2197376254 444 --RSEYKGTGIGLAVCRRIVERHNGQITAVSSPGKGATFSIIIP 485
Cdd:cd16946 66 srNRASGGSGLGLAICHNIALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
363-491 |
7.10e-12 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 67.95 E-value: 7.10e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 363 GDKSQLEQLFLNLVSNALKFQSEGvrpEVTISARDATEEETKDILlaeeydwtKITVSDNGIGFEQSFAEKIFAPFQ--- 439
Cdd:PRK11107 404 GDPLRLQQIITNLVGNAIKFTESG---NIDILVELRALSNTKVQL--------EVQIRDTGIGISERQQSQLFQAFRqad 472
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 2197376254 440 ----RLHGrseykGTGIGLAVCRRIVERHNGQITAVSSPGKGATFSIIIPKNSEPF 491
Cdd:PRK11107 473 asisRRHG-----GTGLGLVITQKLVNEMGGDISFHSQPNRGSTFWFHLPLDLNPN 523
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
368-485 |
8.71e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 61.83 E-value: 8.71e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 368 LEQLFLNLVSNALKFQsegvRPEVTISARDATEEETkdillaeeydwTKITVSDNGIGFEQSFAEKIFAPFQRLH--GRS 445
Cdd:cd16952 1 LRSAFSNLVSNAVKYT----PPSDTITVRWSQEESG-----------ARLSVEDTGPGIPPEHIPRLTERFYRVDieRCR 65
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 2197376254 446 EYKGTGIGLAVCRRIVERHNGQITAVSSPGKGATFSIIIP 485
Cdd:cd16952 66 NTGGTGLGLAIVKHVMSRHDARLLIASELGKGSRFTCLFP 105
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
348-484 |
1.26e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 62.26 E-value: 1.26e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 348 EKSAQINVSDMPTIR--GDKSQLEQLFLNLVSNALKFQSEgvrpEVTISARdateeetkdilLAEEYdwTKITVSDNGIG 425
Cdd:cd16954 16 RKGVSISLDISPELRfpGERNDLMELLGNLLDNACKWCLE----FVEVTAR-----------QTDGG--LHLIVDDDGPG 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 2197376254 426 FEQSFAEKIFAPFQRLHGRSEykGTGIGLAVCRRIVERHNGQITAVSSPGKGATFSIII 484
Cdd:cd16954 79 VPESQRSKIFQRGQRLDEQRP--GQGLGLAIAKEIVEQYGGELSLSDSPLGGARFEVVF 135
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
124-469 |
2.29e-11 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 65.37 E-value: 2.29e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 124 VNEVIEVVELYKEGKEQqaiILVNSDKGLKLYKQFEALFREIdgseqdmqgthlanlmslrRDSVNTLIISSattlLLII 203
Cdd:PRK10755 18 VFQLISVFWLWHESTEQ---IQLLVQATLSARNNDEHVMKEI-------------------REAVASLLVPS----LVMV 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 204 TVFLLLKinsrehekYQA------DLESVNEDLESRIADRTQELSVYSDE-------------LARSNRELED---FAFV 261
Cdd:PRK10755 72 SLTLLIC--------FQAvrwitrPLAELQKELEARTADNLTPIAIHSSTleieavtsalnqlVSRLTSTLDQerlFTAD 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 262 ASHDLQEPLRKIRAFGNRLESgyNDVIDerGKDYLARMlnaaERMSMLISDLLAFSRVstrGKEFDDVNLGTV--VDSIM 339
Cdd:PRK10755 144 VAHELRTPLAGIRLHLELLEK--QHHID--VAPLIARL----DQMMHTVEQLLQLARA---GQSFSSGHYQTVklLEDVI 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 340 GDLEIAIDEKSAQ-------INVSDMPTIRGDKSQLEQLFLNLVSNALKFQSEGVrpevTISardateeetkdILLAEEY 412
Cdd:PRK10755 213 LPSQDELSEMLEQrqqtlllPESAADITVQGDATLLRLLLRNLVENAHRYSPEGS----TIT-----------IKLSQED 277
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 2197376254 413 DWTKITVSDNGIGFEQSFAEKIFAPFQRLHGRseYKGTGIGLAVCRRIVERHNGQIT 469
Cdd:PRK10755 278 GGAVLAVEDEGPGIDESKCGELSKAFVRMDSR--YGGIGLGLSIVSRITQLHHGQFF 332
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
358-485 |
2.81e-11 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 64.72 E-value: 2.81e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 358 MPTIRGDKSQLEQLFLNLVSNALKFQSEgvrPEVTISARDATEEETKdiLLAEEYDWT-KITVSDNGIGFEQSFAEKIFA 436
Cdd:PRK11073 228 LPELAHDPDQIEQVLLNIVRNALQALGP---EGGTITLRTRTAFQLT--LHGERYRLAaRIDIEDNGPGIPPHLQDTLFY 302
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 2197376254 437 PFqrLHGRSeyKGTGIGLAVCRRIVERHNGQITAVSSPGKgATFSIIIP 485
Cdd:PRK11073 303 PM--VSGRE--GGTGLGLSIARNLIDQHSGKIEFTSWPGH-TEFSVYLP 346
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
356-485 |
3.94e-11 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 65.77 E-value: 3.94e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 356 SDMP-TIRGDKSQLEQLFLNLVSNALKFQSEGVrpeVTISARdateeeTKDillaeeyDWTKITVSDNGIGFEQSFAEKI 434
Cdd:PRK10841 550 PDVPvALNGDPMRLQQVISNLLSNAIKFTDTGC---IVLHVR------VDG-------DYLSFRVRDTGVGIPAKEVVRL 613
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 2197376254 435 FAPF-QRLHG-RSEYKGTGIGLAVCRRIVERHNGQITAVSSPGKGATFSIIIP 485
Cdd:PRK10841 614 FDPFfQVGTGvQRNFQGTGLGLAICEKLINMMDGDISVDSEPGMGSQFTIRIP 666
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
263-485 |
6.32e-11 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 64.24 E-value: 6.32e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 263 SHDLQEPLRKIRAfgnRLESGYNDVIDERGKdyLARMLNAAERmsmLISDLLAFSR-----VSTRGKEFDdvnLGTVVDS 337
Cdd:PRK10604 220 AHELRTPLVRLRY---RLEMSDNLSAAESQA--LNRDIGQLEA---LIEELLTYARldrpqNELHLSEPD---LPAWLST 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 338 IMGDLEIAIDEKSAQINVSDMP-TIRGDKSQLEQLFLNLVSNALKFQSEGVRPEVTISARDATeeetkdillaeeydwtk 416
Cdd:PRK10604 289 HLADIQAVTPEKTVRLDTPHQGdYGALDMRLMERVLDNLLNNALRYAHSRVRVSLLLDGNQAC----------------- 351
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2197376254 417 ITVSDNGIGFEQSFAEKIFAPFQRLHGRSEYK--GTGIGLAVCRRIVERHNGQITAVSSPGKGATFSIIIP 485
Cdd:PRK10604 352 LIVEDDGPGIPPEERERVFEPFVRLDPSRDRAtgGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWP 422
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
352-490 |
8.00e-11 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 64.27 E-value: 8.00e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 352 QINVSDMPTIRGDKSQLEQLFLNLVSNALKFQSEGVRPEVTisardaTEEETKDILLaeeyDWTKitvSDNGIGFEQsfA 431
Cdd:PRK10549 337 QLSLPDSATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHIS------AEQRDKTLRL----TFAD---SAPGVSDEQ--L 401
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2197376254 432 EKIFAPFQRLHG---RSEyKGTGIGLAVCRRIVERHNGQITAVSSPGKGATFSIIIPKNSEP 490
Cdd:PRK10549 402 QKLFERFYRTEGsrnRAS-GGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLERDL 462
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
248-485 |
1.13e-10 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 63.39 E-value: 1.13e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 248 LARSNRELED-----FAFVaSHDLQEPLRKIRafgnrLESgynDVIDErGKDYLARMLNA-AERMSMLISDLLAFSRVST 321
Cdd:PRK09467 218 MAAGIKQLEDdrtllMAGV-SHDLRTPLTRIR-----LAT---EMMSE-EDGYLAESINKdIEECNAIIEQFIDYLRTGQ 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 322 RGK-EFDDVN--LGTVVDSIMGDlEIAIDEKSAQInvsdMPTIRGDKSQLEQLFLNLVSNALKFQSEGVRpevtISARDa 398
Cdd:PRK09467 288 EMPmEMADLNalLGEVIAAESGY-EREIETALQPG----PIEVPMNPIAIKRALANLVVNAARYGNGWIK----VSSGT- 357
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 399 teeetkdillaeEYDWTKITVSDNGIGFEQSFAEKIFAPFQRlhG---RSEyKGTGIGLAVCRRIVERHNGQITAVSSPG 475
Cdd:PRK09467 358 ------------EGKRAWFQVEDDGPGIPPEQLKHLFQPFTR--GdsaRGS-SGTGLGLAIVKRIVDQHNGKVELGNSEE 422
|
250
....*....|
gi 2197376254 476 KGATFSIIIP 485
Cdd:PRK09467 423 GGLSARAWLP 432
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
263-485 |
2.06e-10 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 62.64 E-value: 2.06e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 263 SHDLQEPLRKIR---AFGNRLESGYNDvidergkdyLARMLNAAERMSMLISDLLAFSRV---STRGKEFDDVNlgtvvd 336
Cdd:PRK09470 251 SHELRTPLTRLQlatALLRRRQGESKE---------LERIETEAQRLDSMINDLLVLSRNqqkNHLERETFKAN------ 315
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 337 SIMGD-LEIAIDEkSAQIN----VSDMP---TIRGDKSQLEQLFLNLVSNALKFQSEGVRPEVTISARDATeeetkdill 408
Cdd:PRK09470 316 SLWSEvLEDAKFE-AEQMGksltVSAPPgpwPINGNPNALASALENIVRNALRYSHTKIEVAFSVDKDGLT--------- 385
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 409 aeeydwtkITVSDNGIGFEQSFAEKIFAPFQRLhgrSEYK-----GTGIGLAVCRRIVERHNGQITAVSSPGKGATFSII 483
Cdd:PRK09470 386 --------ITVDDDGPGVPEEEREQIFRPFYRV---DEARdresgGTGLGLAIVENAIQQHRGWVKAEDSPLGGLRLTIW 454
|
..
gi 2197376254 484 IP 485
Cdd:PRK09470 455 LP 456
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
368-485 |
5.27e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 56.30 E-value: 5.27e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 368 LEQLFLNLVSNALKFQSEGVRPevtisardATEEETKdillaeeydWTKITVSDNGIGFEQSFAEKIFAPFQRLHGRSEY 447
Cdd:cd16950 1 LKRVLSNLVDNALRYGGGWVEV--------SSDGEGN---------RTRIQVLDNGPGIAPEEVDELFQPFYRGDNARGT 63
|
90 100 110
....*....|....*....|....*....|....*...
gi 2197376254 448 KGTGIGLAVCRRIVERHNGQITAVSSPGKGATFSIIIP 485
Cdd:cd16950 64 SGTGLGLAIVQRISDAHGGSLTLANRAGGGLCARIELP 101
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
351-482 |
1.58e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 55.98 E-value: 1.58e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 351 AQINVSDMPT-IRGDKSQLEQLFLNLVSNALKFQSEGVRPEVTISARDATeeetkdillaeeydwTKITVSDNGIGFEQS 429
Cdd:cd16947 3 VEINIPDRPIyANANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKH---------------VYIDIWDKGKGISET 67
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 2197376254 430 FAEKIFapfQRLH-----GRSEYKGTGIGLAVCRRIVERHNGQITAVSSPGKGATFSI 482
Cdd:cd16947 68 EKDHVF---ERLYtledsRNSAKQGNGLGLTITKRLAESMGGSIYVNSKPYEKTVFTV 122
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
374-489 |
4.38e-09 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 58.77 E-value: 4.38e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 374 NLVSNALkfqsegvrpevtisarDA-TEEETKDILLAEEY--DWTKITVSDNGIGFEQSFAEKIFApfqrlHGRSEyKGT 450
Cdd:PRK11086 440 NLIENAL----------------EAvGGEEGGEISVSLHYrnGWLHCEVSDDGPGIAPDEIDAIFD-----KGYST-KGS 497
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 2197376254 451 --GIGLAVCRRIVERHNGQITAVSSPGKGATFSIIIPKNSE 489
Cdd:PRK11086 498 nrGVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIPWDGE 538
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
368-485 |
1.97e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 52.00 E-value: 1.97e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 368 LEQLFLNLVSNALKFQSEGVRPEVTIsardateeetkdillAEEYDWTKITVSDNGIGFEQSFAEKIFAPFQRLHGRSEY 447
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITS---------------FLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRNT 65
|
90 100 110
....*....|....*....|....*....|....*...
gi 2197376254 448 KGTGIGLAVCRRIVERHNGQITAvSSPGKGATFSIIIP 485
Cdd:cd16923 66 EGAGLGLSIAKAIIELHGGSASA-EYDDNHDLFKVRLP 102
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
368-485 |
4.61e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 51.03 E-value: 4.61e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 368 LEQLFLNLVSNALKFQSEgvrPEVTISARdateeetkdilLAEEYDWTKITVSDNGIGFEQSFAEKIFAPF--QRLHGRS 445
Cdd:cd16953 1 LGQVLRNLIGNAISFSPP---DTGRITVS-----------AMPTGKMVTISVEDEGPGIPQEKLESIFDRFytERPANEA 66
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 2197376254 446 EYKGTGIGLAVCRRIVERHNGQITA--VSSPG--KGATFSIIIP 485
Cdd:cd16953 67 FGQHSGLGLSISRQIIEAHGGISVAenHNQPGqvIGARFTVQLP 110
|
|
| HATPase_ETR2_ERS2-EIN4-like |
cd16938 |
Histidine kinase-like ATPase domain of Arabidopsis thaliana ETR2, ERS2, and EIN4, and related ... |
363-484 |
8.91e-08 |
|
Histidine kinase-like ATPase domain of Arabidopsis thaliana ETR2, ERS2, and EIN4, and related domains; This family includes the histidine kinase-like ATPase domains (HATPase) of three out of the five receptors that recognize the plant hormone ethylene in Arabidopsis thaliana. These three proteins have been classified as belonging to subfamily 2: ETR2, ERS2, and EIN4. They lack most of the motifs characteristic of histidine kinases, and EIN4 is the only one in this group containing the conserved histidine that is phosphorylated in two-component and phosphorelay systems. This family also includes the HATPase domains of Escherichia coli RcsD phosphotransferase which is a component of the Rcs-signaling system, a complex multistep phosphorelay involving five proteins, and is involved in many transcriptional networks such as cell division, biofilm formation, and virulence, among others. Also included is Schizosaccharomyces pombe Mak3 (Phk1) which participates in a multi-step two-component related system which regulates H2O2-induced activation of the Sty1 stress-activated protein kinase pathway. Most proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a GAF sensor domain; most are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340415 [Multi-domain] Cd Length: 133 Bit Score: 50.92 E-value: 8.91e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 363 GDKSQLEQLFLNLVSNALKFQSEG------VRPEVTISARDATEEETKDILLAEEYDWTKITVSDNGIGFEQSFAEKIFA 436
Cdd:cd16938 7 GDERRVFQVLLHMLGNLLKMRNGGgnitfrVFLEGGSEDRSDRDWGPWRPSMSDESVEIRFEVEINDSGSPSIESASMRN 86
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 2197376254 437 PFQRLHGRSEyKGTGIGLAVCRRIVERHNGQITAVSSPGKGATFSIII 484
Cdd:cd16938 87 SLNRRYNLSE-LGEHLSFSICKQLVQLMGGNIWIVPGSGLGTTMSLLL 133
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
252-318 |
1.34e-07 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 48.36 E-value: 1.34e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2197376254 252 NRELEDFAFVASHDLQEPLRKIRAFGNRLESGYNDviDERGKDYLARMLNAAERMSMLISDLLAFSR 318
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLD--DEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
368-480 |
1.93e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 49.38 E-value: 1.93e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 368 LEQLFLNLVSNALKFQSEGvrPEVTISARDATEEetkdillaeeydwTKITVSDNGIGFEQSFAEKIFAPFQRL-HGRSE 446
Cdd:cd16945 5 LRQAINNLLDNAIDFSPEG--GLIALQLEADTEG-------------IELLVFDEGSGIPDYALNRVFERFYSLpRPHSG 69
|
90 100 110
....*....|....*....|....*....|....
gi 2197376254 447 YKGTGIGLAVCRRIVERHNGQITAVSSPGKGATF 480
Cdd:cd16945 70 QKSTGLGLAFVQEVAQLHGGRITLRNRPDGVLAF 103
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
293-486 |
2.95e-07 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 52.85 E-value: 2.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 293 KDYLARMLNAAERMSMLISDLLAFSRVSTRGKEFDDV--NLGTVVDSIMGDLEIAIDEKSAQINVSDMP-TIRGDKSQLE 369
Cdd:PRK09835 298 EDVLYSNLEELTRMAKMVSDMLFLAQADNNQLIPEKKmlDLADEVGKVFDFFEAWAEERGVELRFVGDPcQVAGDPLMLR 377
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 370 QLFLNLVSNALKFQSEGVRpeVTISardateeetkdilLAEEYDWTKITVSDNGIGFEQSFAEKIFAPFQRLHGRSEYKG 449
Cdd:PRK09835 378 RAISNLLSNALRYTPAGEA--ITVR-------------CQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQRKG 442
|
170 180 190
....*....|....*....|....*....|....*....
gi 2197376254 450 --TGIGLAVCRRIVERHNGQItAVSSPGKGATFSIIIPK 486
Cdd:PRK09835 443 egSGIGLAIVKSIVVAHKGTV-AVTSDARGTRFVISLPR 480
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
375-485 |
1.65e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 46.90 E-value: 1.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 375 LVSNALKFQSEGVRPEvtisardateeetkdILLAEEYDWTKITVSDNGIGFEQSFAEKIFAP-FQRLHGRSEYKGTGIG 453
Cdd:cd16948 13 IVSNALKYSKQGGKIE---------------IYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKgFTGENGRNFQESTGMG 77
|
90 100 110
....*....|....*....|....*....|..
gi 2197376254 454 LAVCRRIVERHNGQITAVSSPGKGATFSIIIP 485
Cdd:cd16948 78 LYLVKKLCDKLGHKIDVESEVGEGTTFTITFP 109
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
353-483 |
3.44e-06 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 49.63 E-value: 3.44e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 353 INVSDMPTIRGDKSQLEQLFLNLVSNALKFQSEGVRpevtISARdateeETKDILlaeeydwtKITVSDNGIGFEQSFAE 432
Cdd:PRK10815 364 LDISPEITFVGEKNDFMEVMGNVLDNACKYCLEFVE----ISAR-----QTDEHL--------HIVVEDDGPGIPESKRE 426
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 2197376254 433 KIFAPFQRLHG-RSeykGTGIGLAVCRRIVERHNGQITAVSSPGKGATFSII 483
Cdd:PRK10815 427 LIFDRGQRADTlRP---GQGLGLSVAREITEQYEGKISAGDSPLGGARMEVI 475
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
364-486 |
5.10e-06 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 49.06 E-value: 5.10e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 364 DKSQLEQLFLNLVSNALKfqsegvrpevtISARDATEEETKDILLAEEYDWTKITVSDNGIGFEQSFAEKIFApfQRLHG 443
Cdd:PRK15053 429 DSTEFAAIVGNLLDNAFE-----------ASLRSDEGNKIVELFLSDEGDDVVIEVADQGCGVPESLRDKIFE--QGVST 495
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 2197376254 444 RSEYKGT-GIGLAVCRRIVERHNGQITAVSSPGKGATFSIIIPK 486
Cdd:PRK15053 496 RADEPGEhGIGLYLIASYVTRCGGVITLEDNDPCGTLFSIFIPK 539
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
254-318 |
5.43e-06 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 44.12 E-value: 5.43e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2197376254 254 ELEDFAFVASHDLQEPLRKIRAFGNRLEsgyNDVIDERGKDYLARMLNAAERMSMLISDLLAFSR 318
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLR---DEKLDEEQREYLETILRSAERLLRLINDLLDLSR 62
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
413-489 |
7.21e-06 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 48.48 E-value: 7.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 413 DWTKITVSDNGIGFEQSFAEKIFAPFQrlhgrSEYKGTGIGLAVCRRIVERHNG---QITAVSSPGKGATFSIIIPKNSE 489
Cdd:COG2972 371 DRLVITVEDNGVGMPEEKLEKLLEELS-----SKGEGRGIGLRNVRERLKLYYGeeyGLEIESEPGEGTTVTIRIPLEEE 445
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
254-319 |
8.62e-06 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 43.32 E-value: 8.62e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2197376254 254 ELEDFAFVASHDLQEPLRKIRAFGNRLEsgyNDVIDERGKDYLARMLNAAERMSMLISDLLAFSRV 319
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLL---DTELSEEQREYLETILREAERLLRLINDLLDLSRI 63
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
262-477 |
1.06e-05 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 47.72 E-value: 1.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 262 ASHDLQEPLRKIRAfgnrlesgYNDVI-----DERGKDY-LARMLNAAERMSMLISDLLAFSRVSTRGkefddvNLGTVV 335
Cdd:PRK10337 244 AAHELRSPLAALKV--------QTEVAqlsddDPQARKKaLLQLHAGIDRATRLVDQLLTLSRLDSLD------NLQDVA 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 336 DSIMGDL----EIAIDEKSAQ------INVSDMPTIR-GDKSQLEQLFLNLVSNALKFQSEGVRPEVTISARdateeetk 404
Cdd:PRK10337 310 EIPLEDLlqsaVMDIYHTAQQagidvrLTLNAHPVIRtGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNAR-------- 381
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2197376254 405 dillaeeydwtKITVSDNGIGFEQSFAEKIFAPFQRLHGRsEYKGTGIGLAVCRRIVERHNGQITAVSSPGKG 477
Cdd:PRK10337 382 -----------NFTVRDNGPGVTPEALARIGERFYRPPGQ-EATGSGLGLSIVRRIAKLHGMNVSFGNAPEGG 442
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
25-485 |
1.91e-05 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 47.21 E-value: 1.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 25 ANSFYVVSTLNDLSALEARLFTTNRVINAVNRLHVAVLRVESGQRGYMLTGDEEYLTDYTETLSSLGELMDEVEVSSFSS 104
Cdd:COG3920 11 LALAALLLLAALLLLAAALLLALLALLLLALLLLALLLASALLALLALSAAALAAALAVALAAAVGAAAALLALLVLLLL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 105 DIEGQTNRIENFLSLTKAKVNEVIEVVELYKEGKEQQAIILVNSDKGLKLYKQFEALFREIDGSEQDM----QGTHLANL 180
Cdd:COG3920 91 LLLAAAALALALLLAALAGLLLLAALLLLRLVALLAALALLALLLLLLLLLAILALAELAVALAELAAalllLAEELAAL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 181 MSLRRDSVNTLIISSATTLLLIITVFLLLKINSREHEKYQADLESVNEDLESRIADRTQELSVYSDELARSNRELEDFAF 260
Cdd:COG3920 171 RLAAAALLLLLAALLDLGLALAALAAAALLALLLALELLLALLLLLLLLLALLLVLLAALLRLRAAVLEELERRRRARGL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 261 VASHDLQEPLRKIRAFGNRLESGYNDVIDERgKDYLARMLNAAERMSML--------------ISDLL------------ 314
Cdd:COG3920 251 GRLLLLLLLLLLLLRALLLLAAGIRLVITER-KRAEEELEASLEEKELLlrelhhrvknnlqvVSSLLrlqarraddpea 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 315 --AF----SRVS---------TRGKEFDDVNLGTVVDSIMGDLEIAIDEKSAQInvsdmpTIRGDKSQLEQ-------LF 372
Cdd:COG3920 330 reALeesqNRIQalalvhellYQSEDWEGVDLRDYLRELLEPLRDSYGGRGIRI------ELDGPDVELPAdaavplgLI 403
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 373 LN-LVSNALKF-QSEGVRPEVTISARdateeetkdillaEEYDWTKITVSDNGIGFEQSFAEKifapfqrlhgrseyKGT 450
Cdd:COG3920 404 LNeLVTNALKHaFLSGEGGRIRVSWR-------------REDGRLRLTVSDNGVGLPEDVDPP--------------ARK 456
|
490 500 510
....*....|....*....|....*....|....*
gi 2197376254 451 GIGLAVCRRIVERHNGQITAVSSPgkGATFSIIIP 485
Cdd:COG3920 457 GLGLRLIRALVRQLGGTLELDRPE--GTRVRITFP 489
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
405-489 |
2.05e-05 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 46.15 E-value: 2.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 405 DILLAEEYDWTKITVSDNGIGFEQSFAekifapfqrlhgrseyKGTGIGLAVCRRIVERHNGQITAVSSPGKGATFSIII 484
Cdd:COG4585 184 TVTLEVDDGELTLTVRDDGVGFDPEAA----------------PGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATL 247
|
....*
gi 2197376254 485 PKNSE 489
Cdd:COG4585 248 PLAAA 252
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
364-478 |
1.85e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 40.91 E-value: 1.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 364 DKSQLEQLFLNLVSNALKFqsegvrpevtisardATEEETKDILLAEEYDWTKITVSDNGIGFEQSFAEKIFAPFQRLH- 442
Cdd:cd16975 1 DTLLLSRALINIISNACQY---------------APEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDt 65
|
90 100 110
....*....|....*....|....*....|....*.
gi 2197376254 443 GRSEYKGTGIGLAVCRRIVERHNGQITAVSSPGKGA 478
Cdd:cd16975 66 SRRSGGHYGMGLYIAKNLVEKHGGSLIIENSQKGGA 101
|
|
| SCP-1 |
pfam05483 |
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ... |
80-255 |
1.86e-04 |
|
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.
Pssm-ID: 114219 [Multi-domain] Cd Length: 787 Bit Score: 44.33 E-value: 1.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 80 LTDYTETLSSLGELM---------DEVEVSSFSSDIEGQTNRIEnflSLTKAKVNEVIEVVELYKEGKEQQAIILVNsdk 150
Cdd:pfam05483 351 VTEFEATTCSLEELLrteqqrlekNEDQLKIITMELQKKSSELE---EMTKFKNNKEVELEELKKILAEDEKLLDEK--- 424
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 151 glklyKQFEALFREIDGSEQDMQGthlanLMSLRRDSVNTLIISsattllliitvfllLKINSREHEKYQADLESVNEDL 230
Cdd:pfam05483 425 -----KQFEKIAEELKGKEQELIF-----LLQAREKEIHDLEIQ--------------LTAIKTSEEHYLKEVEDLKTEL 480
|
170 180
....*....|....*....|....*
gi 2197376254 231 ESRIADRTqELSVYSDELARSNREL 255
Cdd:pfam05483 481 EKEKLKNI-ELTAHCDKLLLENKEL 504
|
|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
364-485 |
3.80e-04 |
|
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 41.41 E-value: 3.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 364 DKSQLEQL---FLNLVSNALkfqSEGVRPEVTISARDATEEETKDILLAEEYDWTKITVSDNGIGF-------------- 426
Cdd:cd16916 32 DKSVLEKLadpLTHLLRNAV---DHGIEAPEERLAAGKPPEGTITLRAEHQGNQVVIEVSDDGRGIdrekirekaiergl 108
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 427 ----------EQSFAEKIFAP-FQRLHGRSEYKGTGIGLAVCRRIVERHNGQITAVSSPGKGATFSIIIP 485
Cdd:cd16916 109 itadeaatlsDDEVLNLIFAPgFSTAEQVTDVSGRGVGMDVVKRSIESLGGTIEVESEPGQGTTFTIRLP 178
|
|
| CheA |
COG0643 |
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms]; |
449-485 |
6.39e-04 |
|
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
Pssm-ID: 440408 [Multi-domain] Cd Length: 563 Bit Score: 42.48 E-value: 6.39e-04
10 20 30
....*....|....*....|....*....|....*..
gi 2197376254 449 GTGIGLAVCRRIVERHNGQITAVSSPGKGATFSIIIP 485
Cdd:COG0643 381 GRGVGMDVVKTNIEALGGTIEIESEPGKGTTFTLRLP 417
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
376-485 |
2.71e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 36.76 E-value: 2.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197376254 376 VSNALKfQSEGVRPEVTISARDateeetkdillaeeyDWTKITVSDNGIGFEqsfaekifapfqrlhGRSEYKGTGIGLA 455
Cdd:cd16917 9 LTNALK-HAGASRVRVTLSYTA---------------DELTLTVVDDGVGFD---------------GPAPPGGGGFGLL 57
|
90 100 110
....*....|....*....|....*....|
gi 2197376254 456 VCRRIVERHNGQITAVSSPGKGATFSIIIP 485
Cdd:cd16917 58 GMRERAELLGGTLTIGSRPGGGTRVTARLP 87
|
|
| |
