NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2199290488|ref|WP_239659029|]
View 

1-acyl-sn-glycerol-3-phosphate acyltransferase [Corynebacterium aurimucosum]

Protein Classification

lysophospholipid acyltransferase family protein( domain architecture ID 11415180)

lysophospholipid acyltransferase (LPLAT) family protein may act as an acyltransferase of a de novo or remodeling pathway of glycerophospholipid biosynthesis, catalyzing the incorporation of an acyl group from either acyl-CoAs or acyl-acyl carrier proteins (acyl-ACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid; 1-acyl-sn-glycerol-3-phosphate acyltransferase, for example, converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the 2 position by utilizing either acyl-CoA or acyl-ACP as the fatty acyl donor;

CATH:  1.10.1200.50
EC:  2.3.1.-
Gene Ontology:  GO:0008654|GO:0016746
PubMed:  18718904|18931347
SCOP:  4003349

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 1-189 4.82e-48

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


:

Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 165.18  E-value: 4.82e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2199290488   1 MRLSGEENIPDEGGAVLVCNHTGYMDFLFgafLAYRKKRLVRFLAKAGIFKAPLAGPLLKAMHHVPVDRIDGSA---SMR 77
Cdd:COG0204    31 VRVEGLENLPADGPVLIVANHQSWLDILL---LLAALPRPVRFVAKKELFKIPLLGWLLRALGAIPVDRSKRRAalrALR 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2199290488  78 QAVRLAKEGELVGVFSEGTISRSFEIRSMKSGASRIAYEAGVPVIPQVIFGSQRLWTKGHKKNLGRtktpVFITALEPYC 157
Cdd:COG0204   108 QAVEALKAGESLVIFPEGTRSPDGRLLPFKTGAARLALEAGVPIVPVAIDGTERALPKGFLPRPGK----VTVRIGPPID 183

                         170       180       190
                  ....*....|....*....|....*....|..
gi 2199290488 158 PTGDAEADTAEIKRRMQEALEGLWEQYEAEFG 189
Cdd:COG0204   184 PSDLEGEDRRELAERLRAAIEALLAELRAEAA 215
 
Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 1-189 4.82e-48

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 165.18  E-value: 4.82e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2199290488   1 MRLSGEENIPDEGGAVLVCNHTGYMDFLFgafLAYRKKRLVRFLAKAGIFKAPLAGPLLKAMHHVPVDRIDGSA---SMR 77
Cdd:COG0204    31 VRVEGLENLPADGPVLIVANHQSWLDILL---LLAALPRPVRFVAKKELFKIPLLGWLLRALGAIPVDRSKRRAalrALR 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2199290488  78 QAVRLAKEGELVGVFSEGTISRSFEIRSMKSGASRIAYEAGVPVIPQVIFGSQRLWTKGHKKNLGRtktpVFITALEPYC 157
Cdd:COG0204   108 QAVEALKAGESLVIFPEGTRSPDGRLLPFKTGAARLALEAGVPIVPVAIDGTERALPKGFLPRPGK----VTVRIGPPID 183

                         170       180       190
                  ....*....|....*....|....*....|..
gi 2199290488 158 PTGDAEADTAEIKRRMQEALEGLWEQYEAEFG 189
Cdd:COG0204   184 PSDLEGEDRRELAERLRAAIEALLAELRAEAA 215
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 2-174 1.14e-44

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 155.51  E-value: 1.14e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2199290488   2 RLSGEENIPDEGGAVLVCNHTGYMDFLFgafLAYRKKRLVRFLAKAGIFKAPLAGPLLKAMHHVPVDRIDGS---ASMRQ 78
Cdd:cd07989    13 RVEGLENLPPKGPVIIVANHQSYLDPLV---LGAALPRPIRFVAKKELFKIPFLGWLLRLLGAIPIDRGNGRsarEALRE 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2199290488  79 AVRLAKEGELVGVFSEGTISRSFEIRSMKSGASRIAYEAGVPVIPQVIFGSQRLWTKGHKKNLGRTktpVFITALEPYCP 158
Cdd:cd07989    90 AIEALKEGESVVIFPEGTRSRDGELLPFKSGAFRLAKEAGVPIVPVAISGTWGSLPKGKKLPRPGR---VTVRIGEPIPP 166

                         170
                  ....*....|....*...
gi 2199290488 159 TG--DAEADTAEIKRRMQ 174
Cdd:cd07989   167 EGleLAEEDRKELREKVR 184
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 2-126 3.16e-36

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 130.86  E-value: 3.16e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2199290488   2 RLSGEENIPDEGGAVLVCNHTGYMDFLFGAFLAYRKKRLVRFLAKAGIFKAPLAGPLLKAMHHVPVDRI---DGSASMRQ 78
Cdd:pfam01553   3 EVHGLENLPRGGPAIVVANHQSYLDVLLLSLALYKRGRPLVFVAKKELFDIPLVGWLMRLLGCIFIDRKnrkDAAGTLEY 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2199290488  79 AVRLAKEGELVGVFSEGTISRSFEIRSMKSGASRIAYEAGVPVIPQVI 126
Cdd:pfam01553  83 LVELLREGKLVVIFPEGTRSREGELLPFKKGAFRLAIEAGVPIVPVAI 130
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 15-129 1.17e-33

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 123.23  E-value: 1.17e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2199290488   15 AVLVCNHTGYMDFLFGAFLAYRKKRLVRFLAKAGIFKAPLAGPLLKAMHHVPVDRIDG---SASMRQAVRLAKEGELVGV 91
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLPRKLGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGrkaRAALREAVELLKEGEWLLI 80

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 2199290488   92 FSEGTISRSFEIRSMKSGASRIAYEAGVPVIPQVIFGS 129
Cdd:smart00563  81 FPEGTRSRPGKLLPFKKGAARLALEAGVPIVPVAIRGT 118
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 5-126 9.68e-25

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 99.34  E-value: 9.68e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2199290488   5 GEENIPDEGGAVLVCNHTGYMD-FLFGAFLAYRkkrlVRFLAKAGIFKAPLAGPLLKAMHHVPVDR---IDGSASMRQAV 80
Cdd:TIGR00530   8 GPENLPAKSPVLVVANHQSNLDpLTLSAAFPPP----IVFIAKKELKWIPFFGIMLWLTGAIFIDReniRAIATALKAAI 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2199290488  81 RLAKEGELVGVFSEGTISRSFEIRSMKSGASRIAYEAGVPVIPQVI 126
Cdd:TIGR00530  84 EVLKQGRSIGVFPEGTRSRGRDILPFKKGAFHIAIKAGVPILPVVL 129
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 2-202 3.40e-20

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 94.61  E-value: 3.40e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2199290488    2 RLSGEENIPDEGGAVLVCNHTGYMDflfGAFLAYRKKRLVRFLAKAGIFKAPLAGPLLKAMHHVPVDRiDGSASMRQAVR 81
Cdd:PRK08633   430 RVEGRENIPAKGGALLLGNHVSWID---WALLQAASPRPIRFVMERSIYEKWYLKWFFKLFGVIPISS-GGSKESLEFIR 505

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2199290488   82 LA-KEGELVGVFSEGTISRSFEIRSMKSGASRIAYEAGVPVIPQVIFGsqrLW----TKGHKKNLGRTKT----PVFITA 152
Cdd:PRK08633   506 KAlDDGEVVCIFPEGAITRNGQLNEFKRGFELIVKGTDVPIIPFYIRG---LWgsifSRASGKFLWRWPTripyPVTVAF 582

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 2199290488  153 LEPYcptgDAEADTAEIKRRMQEALEGLWEQYEAEFGPMPagEYWVPARK 202
Cdd:PRK08633   583 GKPM----PAHSTAHEVKQAVFELSFDSWKSRKEALPPLA--EAWIDTAK 626
 
Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 1-189 4.82e-48

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 165.18  E-value: 4.82e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2199290488   1 MRLSGEENIPDEGGAVLVCNHTGYMDFLFgafLAYRKKRLVRFLAKAGIFKAPLAGPLLKAMHHVPVDRIDGSA---SMR 77
Cdd:COG0204    31 VRVEGLENLPADGPVLIVANHQSWLDILL---LLAALPRPVRFVAKKELFKIPLLGWLLRALGAIPVDRSKRRAalrALR 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2199290488  78 QAVRLAKEGELVGVFSEGTISRSFEIRSMKSGASRIAYEAGVPVIPQVIFGSQRLWTKGHKKNLGRtktpVFITALEPYC 157
Cdd:COG0204   108 QAVEALKAGESLVIFPEGTRSPDGRLLPFKTGAARLALEAGVPIVPVAIDGTERALPKGFLPRPGK----VTVRIGPPID 183

                         170       180       190
                  ....*....|....*....|....*....|..
gi 2199290488 158 PTGDAEADTAEIKRRMQEALEGLWEQYEAEFG 189
Cdd:COG0204   184 PSDLEGEDRRELAERLRAAIEALLAELRAEAA 215
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 2-174 1.14e-44

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 155.51  E-value: 1.14e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2199290488   2 RLSGEENIPDEGGAVLVCNHTGYMDFLFgafLAYRKKRLVRFLAKAGIFKAPLAGPLLKAMHHVPVDRIDGS---ASMRQ 78
Cdd:cd07989    13 RVEGLENLPPKGPVIIVANHQSYLDPLV---LGAALPRPIRFVAKKELFKIPFLGWLLRLLGAIPIDRGNGRsarEALRE 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2199290488  79 AVRLAKEGELVGVFSEGTISRSFEIRSMKSGASRIAYEAGVPVIPQVIFGSQRLWTKGHKKNLGRTktpVFITALEPYCP 158
Cdd:cd07989    90 AIEALKEGESVVIFPEGTRSRDGELLPFKSGAFRLAKEAGVPIVPVAISGTWGSLPKGKKLPRPGR---VTVRIGEPIPP 166

                         170
                  ....*....|....*...
gi 2199290488 159 TG--DAEADTAEIKRRMQ 174
Cdd:cd07989   167 EGleLAEEDRKELREKVR 184
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 2-126 3.16e-36

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 130.86  E-value: 3.16e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2199290488   2 RLSGEENIPDEGGAVLVCNHTGYMDFLFGAFLAYRKKRLVRFLAKAGIFKAPLAGPLLKAMHHVPVDRI---DGSASMRQ 78
Cdd:pfam01553   3 EVHGLENLPRGGPAIVVANHQSYLDVLLLSLALYKRGRPLVFVAKKELFDIPLVGWLMRLLGCIFIDRKnrkDAAGTLEY 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2199290488  79 AVRLAKEGELVGVFSEGTISRSFEIRSMKSGASRIAYEAGVPVIPQVI 126
Cdd:pfam01553  83 LVELLREGKLVVIFPEGTRSREGELLPFKKGAFRLAIEAGVPIVPVAI 130
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 15-129 1.17e-33

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 123.23  E-value: 1.17e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2199290488   15 AVLVCNHTGYMDFLFGAFLAYRKKRLVRFLAKAGIFKAPLAGPLLKAMHHVPVDRIDG---SASMRQAVRLAKEGELVGV 91
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLPRKLGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGrkaRAALREAVELLKEGEWLLI 80

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 2199290488   92 FSEGTISRSFEIRSMKSGASRIAYEAGVPVIPQVIFGS 129
Cdd:smart00563  81 FPEGTRSRPGKLLPFKKGAARLALEAGVPIVPVAIRGT 118
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 5-126 9.68e-25

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 99.34  E-value: 9.68e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2199290488   5 GEENIPDEGGAVLVCNHTGYMD-FLFGAFLAYRkkrlVRFLAKAGIFKAPLAGPLLKAMHHVPVDR---IDGSASMRQAV 80
Cdd:TIGR00530   8 GPENLPAKSPVLVVANHQSNLDpLTLSAAFPPP----IVFIAKKELKWIPFFGIMLWLTGAIFIDReniRAIATALKAAI 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2199290488  81 RLAKEGELVGVFSEGTISRSFEIRSMKSGASRIAYEAGVPVIPQVI 126
Cdd:TIGR00530  84 EVLKQGRSIGVFPEGTRSRGRDILPFKKGAFHIAIKAGVPILPVVL 129
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 2-202 3.40e-20

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 94.61  E-value: 3.40e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2199290488    2 RLSGEENIPDEGGAVLVCNHTGYMDflfGAFLAYRKKRLVRFLAKAGIFKAPLAGPLLKAMHHVPVDRiDGSASMRQAVR 81
Cdd:PRK08633   430 RVEGRENIPAKGGALLLGNHVSWID---WALLQAASPRPIRFVMERSIYEKWYLKWFFKLFGVIPISS-GGSKESLEFIR 505

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2199290488   82 LA-KEGELVGVFSEGTISRSFEIRSMKSGASRIAYEAGVPVIPQVIFGsqrLW----TKGHKKNLGRTKT----PVFITA 152
Cdd:PRK08633   506 KAlDDGEVVCIFPEGAITRNGQLNEFKRGFELIVKGTDVPIIPFYIRG---LWgsifSRASGKFLWRWPTripyPVTVAF 582

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 2199290488  153 LEPYcptgDAEADTAEIKRRMQEALEGLWEQYEAEFGPMPagEYWVPARK 202
Cdd:PRK08633   583 GKPM----PAHSTAHEVKQAVFELSFDSWKSRKEALPPLA--EAWIDTAK 626
LPLAT_ABO13168-like cd07988
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 1-172 4.57e-19

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized phospholipid/glycerol acyltransferases such as the Acinetobacter baumannii ATCC 17978 locus ABO13168 putative acyltransferase, and similar proteins.


Pssm-ID: 153250 [Multi-domain]  Cd Length: 163  Bit Score: 84.19  E-value: 4.57e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2199290488   1 MRLSG---EENIPDEGGAVL-VCNHTGYMDFLFGAFLAYRKKRLVRFLAKAGIFKAPLaGPLLKAMHHVPVDRIDGSASM 76
Cdd:cd07988     5 LRLSGwriEGEPPNKPKFVViGAPHTSNWDFVLGLLAAFALGLKISFLGKHSLFKPPL-GPFMRWLGGIPVDRSRAGGLV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2199290488  77 RQAVRLAKEGE--LVGVFSEGTISRSfeiRSMKSGASRIAYEAGVPVIPqVIFGSQRlwtkghkknlgrtKTpvfITALE 154
Cdd:cd07988    84 EQVVEEFRRREefVLAIAPEGTRSKV---DKWKTGFYHIARGAGVPILL-VYLDYKR-------------KT---VGIGP 143

                         170
                  ....*....|....*...
gi 2199290488 155 PYCPTGDAEADTAEIKRR 172
Cdd:cd07988   144 LFEPSGDIEADLAAIRAF 161
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 4-178 4.48e-17

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 79.38  E-value: 4.48e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2199290488   4 SGEENIPDEGGAVLVCNHTGYMDFLFGAFLAYR-KKRLVRFLAKAgifKAPLAGPLLKAMHHVPVDR---IDGSASMRQA 79
Cdd:cd06551    17 KGPPPPPGGGPVLFVSNHSSWWDGLILFLLLERgLRRDVYGLMDE---ELLERYPFFTRLGAFSVDRdspRSAAKSLKYV 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2199290488  80 VRLAKE-GELVGVFSEGTISR-SFEIRSMKSGASRIAYEAGVPVIPQVIFGsqrlwtkghkKNLGRTKTP---VFITALE 154
Cdd:cd06551    94 ARLLSKpGSVVWIFPEGTRTRrDKRPLQFKPGVAHLAEKAGVPIVPVALRY----------TFELFEQFPeifVRIGPPI 163

                         170       180
                  ....*....|....*....|....
gi 2199290488 155 PYCPTGDAEADTAEIKRRMQEALE 178
Cdd:cd06551   164 PYAETALGEELAAELANRLTRLLD 187
LPLAT_AAK14816-like cd07992
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 1-123 9.17e-17

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized glycerol-3-phosphate acyltransferases such as the Plasmodium falciparum locus AAK14816 putative acyltransferase, and similar proteins.


Pssm-ID: 153254 [Multi-domain]  Cd Length: 203  Bit Score: 78.84  E-value: 9.17e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2199290488   1 MRLSGEENIPDEGGAVLVCNHTGymDFLFGAFLAYRKKRLVRFLAKAGIFKAPLAGPLLKAMHHVPVDR----------- 69
Cdd:cd07992    16 ITVVGRENVPKDGPVIFLGNHPN--ALIDPLLLAATLRRPVRFLAKADLFKNPLIGWLLESFGAIPVYRpkdlarggigk 93

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2199290488  70 IDGSASMRQAVRLAKEGELVGVFSEGTISRSFEIRSMKSGASRIAYEA------GVPVIP 123
Cdd:cd07992    94 ISNAAVFDAVGEALKAGGAIGIFPEGGSHDRPRLLPLKAGAARMALEAleagqkDVKIVP 153
LPLAT_MGAT-like cd07987
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; ...
 5-184 2.72e-15

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this suubgroup are such LPLATs as 2-acylglycerol O-acyltransferase (MGAT), and similar proteins.


Pssm-ID: 153249 [Multi-domain]  Cd Length: 212  Bit Score: 74.63  E-value: 2.72e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2199290488   5 GEENIPDEGGAVLVCNHTGY-MDFLFGA--FLAYRKKRLVRFLAKAGIFKAPLAGPLLKAMHHVPVDRidgsasmRQAVR 81
Cdd:cd07987    12 GLENIPDEGPALLVHPHGGLpIDGALLAaaFLLLFPGRLPRALADHFLFPLPGLRDLLRRLGAVPGSR-------ENCVR 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2199290488  82 LAKEGELVGVFSEGT--ISRSFE-----IRSMKSGASRIAYEAGVPVIPQVIFGSQRLWT----------KGHKKNLG-R 143
Cdd:cd07987    85 LLREGELVLIFPGGAreALKSKReeyylLWKKRKGFARLALRAGAPIVPVFTFGEEELFRvlgdpdgpvgKRLFRLLPlP 164

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 2199290488 144 TKTPVFI----TALEPYCPTGDAEADTAE-IKRRMQEALEGLWEQY 184
Cdd:cd07987   165 RRLPLYPvfgePIVVPRPPIPDPPDEDVEeLHQKYIAALRELIEKH 210
PLN02901 PLN02901
1-acyl-sn-glycerol-3-phosphate acyltransferase
 1-177 8.16e-15

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 215488 [Multi-domain]  Cd Length: 214  Bit Score: 73.61  E-value: 8.16e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2199290488   1 MRLSGEENIP-DEGGAVLVCNHTGYMDFlfgaFLAYRKKRLVRFLAKAGIFKAPLAGPLLKAMHHVPVDRIDGSASM--- 76
Cdd:PLN02901   37 IEVEGLENLPsPDEPAVYVSNHQSFLDI----YTLFHLGRPFKFISKTSIFLIPIIGWAMYMTGHIPLKRMDRRSQLecl 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2199290488  77 RQAVRLAKEGELVGVFSEGTISRSFEIRSMKSGASRIAYEAGVPVIPQVIFGSQRLWTKGHKKNLGRTKTPVFItalEPY 156
Cdd:PLN02901  113 KRCMELLKKGASVFFFPEGTRSKDGKLAAFKKGAFSVAAKTGVPVVPITLVGTGKIMPNGKEGILNPGSVKVVI---HPP 189

                         170       180
                  ....*....|....*....|.
gi 2199290488 157 CPTGDAEADTAEIKRRMQEAL 177
Cdd:PLN02901  190 IEGSDADELCNEARKVIAESL 210
LPLAT_ACT14924-like cd07986
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 1-133 6.11e-13

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized phospholipid/glycerol acyltransferases such as the Pectobacterium carotovorum subsp. carotovorum PC1 locus ACT14924 putative acyltransferase, and similar proteins.


Pssm-ID: 153248 [Multi-domain]  Cd Length: 210  Bit Score: 67.66  E-value: 6.11e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2199290488   1 MRLSGEENIPDEGGAVLVCNH-TGYMDFLFGAFLAYRKKRLVRFLAKAGIFKAPLAGPLLkamhhVPVDRIDG------- 72
Cdd:cd07986    10 VDVSGLENIPKDGPVVIVANHpFGILDGLILADLLGSVRPDVRILANQLLSKIPELRDLF-----IPVDPLEGraalakn 84

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2199290488  73 SASMRQAVRLAKEGELVGVFSEGTISRSFEIRS------MKSGASRIAYEAGVPVIPQVIFGSQRLW 133
Cdd:cd07986    85 RESLREALRHLKNGGALIIFPAGRVSTASPPFGrvsdrpWNPFVARLARKAKAPVVPVYFSGRNSRL 151
LPLAT_LPCAT1-like cd07991
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; ...
 2-163 9.51e-10

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lysophosphatidylcholine acyltransferase 1 (LPCAT-1), glycerol-3-phosphate acyltransferase 3 (GPAT3), and similar sequences.


Pssm-ID: 153253 [Multi-domain]  Cd Length: 211  Bit Score: 58.39  E-value: 9.51e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2199290488   2 RLSGEENiPDEGGAVLVCNHTGYMDFLfgaFLAYRkkRLVRFLAKAGIFKAPLAGPLLKAMHHVPVDRIDGSASMRQAVR 81
Cdd:cd07991    14 KVHGKPD-PPEAPRIIVANHTSFIDPL---ILFSD--LFPSIVAKKELGKLPFIGTILRALGCIFVDRSEPKDRKKVVEE 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2199290488  82 LAKEGEL-----VGVFSEGTISRSFEIRSMKSGasriAYEAGVPVIPQVI----FGSQRLWTK---GHKKNLGRTKTPVF 149
Cdd:cd07991    88 IKERATDpnwppILIFPEGTTTNGKALIMFKKG----AFEPGVPVQPVAIrypnKFVDAFWNSsgySSLMYLFRLLTQPA 163

                         170
                  ....*....|....*...
gi 2199290488 150 ITA----LEPYCPTGDAE 163
Cdd:cd07991   164 NVLevefLPVYTPSEEGE 181
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 2-96 4.75e-09

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 56.09  E-value: 4.75e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2199290488   2 RLSGEENIPDEGGAVLVCNHTGYMDFLFGAFLAYRKKRL--VRFLAKAGIFKAPLAGPLLKAMHHVPVDR---IDGSASM 76
Cdd:cd07990    13 VVYGDEPKLPKERALIISNHRSEVDWLVLWMLADRFGRLgrLKIVLKDSLKYPPLGGWGWQLGEFIFLKRkweKDEKTIK 92

                          90       100
                  ....*....|....*....|...
gi 2199290488  77 RQAVRLAKEGE---LVgVFSEGT 96
Cdd:cd07990    93 RQLKRLKDSPEpfwLL-IFPEGT 114
COG3176 COG3176
Putative hemolysin [General function prediction only];
7-128 3.98e-06

Putative hemolysin [General function prediction only];


Pssm-ID: 442409  Cd Length: 270  Bit Score: 48.50  E-value: 3.98e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2199290488   7 ENIPDEGGAVLVCNH-TGYMDFLFGAFLAYRKKRLVRFLAKAGIFKAPlaGPLLKAMhHVPVDRiDGSASMRQAVRLAKE 85
Cdd:COG3176    65 DRIDADGHLLVVANHpLGILDGLALLKLVGTVRPDYRILANDLALRIP--GGFYSEL-EFPVDP-FNLETLKAARRHLLE 140

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2199290488  86 GELVGVFSEGTISRSFEIRSM--KSGASRIAYEAGVPVIPQVIFG 128
Cdd:COG3176   141 GGRSCVFPAGRVSGARRVIDLlwSGLAAKLARKAGAPVVPVYFDG 185
LPLAT_DUF374-like cd07983
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; ...
 72-178 2.96e-03

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are the uncharacterized DUF374 phospholipid/glycerol acyltransferases and similar proteins.


Pssm-ID: 153245 [Multi-domain]  Cd Length: 189  Bit Score: 38.73  E-value: 2.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2199290488  72 GSASMRQAVRLAKEGELVGVFSEGtiSRSfEIRSMKSGASRIAYEAGVPVIPqVIFGSQRLWTkghKKNLGRTKTP---- 147
Cdd:cd07983    83 GAAALREMLRALKDGYNIAITPDG--PRG-PRYKVKPGVILLARKSGAPIVP-VAIAASRAWR---LKSWDRFIIPkpfs 155

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2199290488 148 -VFITALEP-YCPTGDAEADTAEIKRRMQEALE 178
Cdd:cd07983   156 rVVIVFGEPiHVPPDADEEELEEYRLELEAALN 188
LPLAT_LABLAT-like cd07984
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; ...
 1-184 6.07e-03

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lipid A biosynthesis lauroyl/myristoyl (LABLAT, HtrB) acyltransferases and similar proteins.


Pssm-ID: 153246 [Multi-domain]  Cd Length: 192  Bit Score: 37.96  E-value: 6.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2199290488   1 MRLSGEENIP---DEG-GAVLVCNHTGYMDFLfGAFLAYRKKRLvrflakAGIFKaPLAGPLLKAM--------HHVPVD 68
Cdd:cd07984     4 VEREGLEHLEaalAKGkGVILLTAHFGNWELA-GLALALLGYPV------TVVYR-PLKNPLLDRLitrgrerfGARLIP 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2199290488  69 RIDGsasMRQAVRLAKEGELVGVFSEGTISRSFEIR--------SMKSGASRIAYEAGVPVIPqvIFGSqRLWTKGHKkn 140
Cdd:cd07984    76 RGGG---LRELIRALKKGEIVGILPDQDPGRKGGVFvpffgrpaATPTGPARLALKTGAPVVP--AFAY-RLPGGGYR-- 147

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 2199290488 141 lgrtktpVFITALEPYCPTGDAEADTAeikrRMQEALEGLW----EQY 184
Cdd:cd07984   148 -------IEFEPPLENPPSEDVEEDTQ----RLNDALEAAIrehpEQW 184
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH