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Conserved domains on  [gi|2204475704|ref|WP_240629340|]
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MULTISPECIES: N-acetyltransferase [unclassified Veillonella]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 18514852)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.1.-
Gene Ontology:  GO:0008080
PubMed:  15581578|9175471|10940244
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 90-175 5.71e-19

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


:

Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 77.00  E-value: 5.71e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204475704  90 ENAFEVQRLYVLKEYHGQGVGKALFEKALRIAESGNFSWAWLGVWEKNYKAQHFYKRYGFEKFGEHqfvvTPEKTDIDWL 169
Cdd:COG0456    11 GDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNEAAIALYEKLGFEEVGER----PNYYGDDALV 86


                  ....*.
gi 2204475704 170 LKKSLR 175
Cdd:COG0456    87 MEKELA 92
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
9-154 1.25e-16

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


:

Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 72.72  E-value: 1.25e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204475704   9 RAQETDIPALSNLCADTFRE---TFSHDN-TEEELQAFFdeaynhdvlkRELDHDESETYLAYVDDVLAGYLKInwGDAQ 84
Cdd:COG1247     6 PATPEDAPAIAAIYNEAIAEgtaTFETEPpSEEEREAWF----------AAILAPGRPVLVAEEDGEVVGFASL--GPFR 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204475704  85 TERKLENAFEVQrLYVLKEYHGQGVGKALFEKALRIAESGNFSWAWLGVWEKNYKAQHFYKRYGFEKFGE 154
Cdd:COG1247    74 PRPAYRGTAEES-IYVDPDARGRGIGRALLEALIERARARGYRRLVAVVLADNEASIALYEKLGFEEVGT 142
 
Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 90-175 5.71e-19

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 77.00  E-value: 5.71e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204475704  90 ENAFEVQRLYVLKEYHGQGVGKALFEKALRIAESGNFSWAWLGVWEKNYKAQHFYKRYGFEKFGEHqfvvTPEKTDIDWL 169
Cdd:COG0456    11 GDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNEAAIALYEKLGFEEVGER----PNYYGDDALV 86


                  ....*.
gi 2204475704 170 LKKSLR 175
Cdd:COG0456    87 MEKELA 92
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
9-154 1.25e-16

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 72.72  E-value: 1.25e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204475704   9 RAQETDIPALSNLCADTFRE---TFSHDN-TEEELQAFFdeaynhdvlkRELDHDESETYLAYVDDVLAGYLKInwGDAQ 84
Cdd:COG1247     6 PATPEDAPAIAAIYNEAIAEgtaTFETEPpSEEEREAWF----------AAILAPGRPVLVAEEDGEVVGFASL--GPFR 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204475704  85 TERKLENAFEVQrLYVLKEYHGQGVGKALFEKALRIAESGNFSWAWLGVWEKNYKAQHFYKRYGFEKFGE 154
Cdd:COG1247    74 PRPAYRGTAEES-IYVDPDARGRGIGRALLEALIERARARGYRRLVAVVLADNEASIALYEKLGFEEVGT 142
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 33-156 3.34e-15

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 68.07  E-value: 3.34e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204475704  33 DNTEEELQAFFDEAYNhDVLKRELDHDESETYLAYVDDVLAGYLKInwgdaQTERKLEnafevqRLYVLKEYHGQGVGKA 112
Cdd:pfam13673   4 DYSEEGIETFYEFISP-EALRERIDQGEYFFFVAFEGGQIVGVIAL-----RDRGHIS------LLFVDPDYQGQGIGKA 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2204475704 113 LFEKALRIAESGNFSWAWLGVWEKNYkAQHFYKRYGFEKFGEHQ 156
Cdd:pfam13673  72 LLEAVEDYAEKDGIKLSELTVNASPY-AVPFYEKLGFRATGPEQ 114
rimI TIGR01575
ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related ...
 40-155 2.88e-10

ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273701 [Multi-domain]  Cd Length: 131  Bit Score: 55.41  E-value: 2.88e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204475704  40 QAFFDEAYNHDVLKRELDHDESETYLAYVDDVLAGYL--KINWGDAqterklenafEVQRLYVLKEYHGQGVGKALFEKA 117
Cdd:TIGR01575  10 AAAFAFPWTEAQFAEELANYHLCYLLARIGGKVVGYAgvQIVLDEA----------HILNIAVKPEYQGQGIGRALLREL 79

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2204475704 118 LRIAESGNFSWAWLGVWEKNYKAQHFYKRYGFEKFGEH 155
Cdd:TIGR01575  80 IDEAKGRGVNEIFLEVRVSNIAAQALYKKLGFNEIAIR 117
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 64-131 1.20e-08

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 49.20  E-value: 1.20e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2204475704  64 YLAYVDDVLAGYLKINWgdaqtERKLENAFEVQRLYVLKEYHGQGVGKALFEKALRIAESGNFSWAWL 131
Cdd:cd04301     2 LVAEDDGEIVGFASLSP-----DGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRL 64
PRK10514 PRK10514
putative acetyltransferase; Provisional
 98-153 8.37e-05

putative acetyltransferase; Provisional


Pssm-ID: 182510 [Multi-domain]  Cd Length: 145  Bit Score: 40.76  E-value: 8.37e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2204475704  98 LYVLKEYHGQGVGKALFEKALRIAEsgNFSwawLGVWEKNYKAQHFYKRYGFEKFG 153
Cdd:PRK10514   75 LFVDPDVRGCGVGRMLVEHALSLHP--ELT---TDVNEQNEQAVGFYKKMGFKVTG 125
Spm_actase_Thplmales NF041158
spermidine N(1)-acetyltransferase;
14-120 4.92e-03

spermidine N(1)-acetyltransferase;


Pssm-ID: 469070  Cd Length: 115  Bit Score: 35.29  E-value: 4.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204475704  14 DIPALSNLCADTFRETFSHDNTEEELQAFFDEAYNHDVLKRELDHDESETYL----AYVDDVLAGYLKInwgdaqteRKL 89
Cdd:NF041158   11 DVDALIEVARESWKWTYRDIYSNEFIESWISEKYSKEKLLNEIIRSQSNLDIiflgAFVNSALIGFIEL--------KII 82

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2204475704  90 ENAFEVQRLYVLKEYHGQGVGKALFEKALRI 120
Cdd:NF041158   83 ADKAELLRLYLKPEYTHRGIGKLLLSEAEKI 113
 
Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 90-175 5.71e-19

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 77.00  E-value: 5.71e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204475704  90 ENAFEVQRLYVLKEYHGQGVGKALFEKALRIAESGNFSWAWLGVWEKNYKAQHFYKRYGFEKFGEHqfvvTPEKTDIDWL 169
Cdd:COG0456    11 GDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNEAAIALYEKLGFEEVGER----PNYYGDDALV 86


                  ....*.
gi 2204475704 170 LKKSLR 175
Cdd:COG0456    87 MEKELA 92
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 25-162 6.48e-18

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 75.48  E-value: 6.48e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204475704  25 TFRETFSHDNTEEELQAFFDEaynhDVLKRELDHDESETYLAYVDDVLAGYLKINWGDaqterklENAFEVQRLYVLKEY 104
Cdd:COG0454     2 SIRKATPEDINFILLIEALDA----ELKAMEGSLAGAEFIAVDDKGEPIGFAGLRRLD-------DKVLELKRLYVLPEY 70

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2204475704 105 HGQGVGKALFEKALRIAESGNFSWAWLGVWEKNYKAQHFYKRYGFEKFGEHQFVVTPE 162
Cdd:COG0454    71 RGKGIGKALLEALLEWARERGCTALELDTLDGNPAAIRFYERLGFKEIERYVAYVGGE 128
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
9-154 1.25e-16

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 72.72  E-value: 1.25e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204475704   9 RAQETDIPALSNLCADTFRE---TFSHDN-TEEELQAFFdeaynhdvlkRELDHDESETYLAYVDDVLAGYLKInwGDAQ 84
Cdd:COG1247     6 PATPEDAPAIAAIYNEAIAEgtaTFETEPpSEEEREAWF----------AAILAPGRPVLVAEEDGEVVGFASL--GPFR 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204475704  85 TERKLENAFEVQrLYVLKEYHGQGVGKALFEKALRIAESGNFSWAWLGVWEKNYKAQHFYKRYGFEKFGE 154
Cdd:COG1247    74 PRPAYRGTAEES-IYVDPDARGRGIGRALLEALIERARARGYRRLVAVVLADNEASIALYEKLGFEEVGT 142
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 33-156 3.34e-15

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 68.07  E-value: 3.34e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204475704  33 DNTEEELQAFFDEAYNhDVLKRELDHDESETYLAYVDDVLAGYLKInwgdaQTERKLEnafevqRLYVLKEYHGQGVGKA 112
Cdd:pfam13673   4 DYSEEGIETFYEFISP-EALRERIDQGEYFFFVAFEGGQIVGVIAL-----RDRGHIS------LLFVDPDYQGQGIGKA 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2204475704 113 LFEKALRIAESGNFSWAWLGVWEKNYkAQHFYKRYGFEKFGEHQ 156
Cdd:pfam13673  72 LLEAVEDYAEKDGIKLSELTVNASPY-AVPFYEKLGFRATGPEQ 114
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 37-149 2.01e-14

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 66.00  E-value: 2.01e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204475704  37 EELQAFFDEAYNH---DVLKRELDHDESETYLAYVDDVLAGYLKINWGDAQTERklenaFEVQRLYVLKEYHGQGVGKAL 113
Cdd:pfam00583   6 ELLSEEFPEPWPDeplDLLEDWDEDASEGFFVAEEDGELVGFASLSIIDDEPPV-----GEIEGLAVAPEYRGKGIGTAL 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2204475704 114 FEKALRIAESGNFSWAWLGVWEKNYKAQHFYKRYGF 149
Cdd:pfam00583  81 LQALLEWARERGCERIFLEVAADNLAAIALYEKLGF 116
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
9-162 3.61e-14

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 65.88  E-value: 3.61e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204475704   9 RAQETDIPALSNLCADTFRETfshdnTEEELQAFFDEaynhdvlkrelDHDESETYLAYVDDVLAGYLKINWGDAQTERk 88
Cdd:COG3153     3 PATPEDAEAIAALLRAAFGPG-----REAELVDRLRE-----------DPAAGLSLVAEDDGEIVGHVALSPVDIDGEG- 65

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2204475704  89 leNAFEVQRLYVLKEYHGQGVGKALFEKALRIAESGNFSWAWLGVWEKNykaQHFYKRYGFEKFGEHQFVVTPE 162
Cdd:COG3153    66 --PALLLGPLAVDPEYRGQGIGRALMRAALEAARERGARAVVLLGDPSL---LPFYERFGFRPAGELGLTLGPD 134
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 56-175 4.95e-13

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 62.70  E-value: 4.95e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204475704  56 LDHDESETYLAYVDDVLAGY--LKINWGDAqterklenaFEVQRLYVLKEYHGQGVGKALFEKALRIAESGNFSWAWLGV 133
Cdd:COG1246    23 LEEEIGEFWVAEEDGEIVGCaaLHPLDEDL---------AELRSLAVHPDYRGRGIGRRLLEALLAEARELGLKRLFLLT 93

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2204475704 134 wekNYKAQHFYKRYGFEKFGEHQFVVTPEKTDIDWLLKKSLR 175
Cdd:COG1246    94 ---TSAAIHFYEKLGFEEIDKEDLPYAKVWQRDSVVMEKDLE 132
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 59-151 8.27e-13

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 60.93  E-value: 8.27e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204475704  59 DESETYLAYVDDVLAGYLKINWGDAqterklENAFEVQRLYVLKEYHGQGVGKALFEKALRIAESGNFSWAWLGVwekNY 138
Cdd:pfam13508   1 PGGRFFVAEDDGKIVGFAALLPLDD------EGALAELRLAVHPEYRGQGIGRALLEAAEAAAKEGGIKLLELET---TN 71

                          90
                  ....*....|...
gi 2204475704 139 KAQHFYKRYGFEK 151
Cdd:pfam13508  72 RAAAFYEKLGFEE 84
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
55-154 2.09e-12

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 60.97  E-value: 2.09e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204475704  55 ELDHDESETY--LAYVDDVLAGYLKINWGDAQTerklenaFEVQRLYVLKEYHGQGVGKALFEKALRIAESGNFSWAWLG 132
Cdd:COG2153    26 ELDGKDEDARhlLAYDDGELVATARLLPPGDGE-------AKIGRVAVLPEYRGQGLGRALMEAAIEEARERGARRIVLS 98

                          90       100
                  ....*....|....*....|....*.
gi 2204475704 133 vweknykAQH----FYKRYGFEKFGE 154
Cdd:COG2153    99 -------AQAhavgFYEKLGFVPVGE 117
rimI TIGR01575
ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related ...
 40-155 2.88e-10

ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273701 [Multi-domain]  Cd Length: 131  Bit Score: 55.41  E-value: 2.88e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204475704  40 QAFFDEAYNHDVLKRELDHDESETYLAYVDDVLAGYL--KINWGDAqterklenafEVQRLYVLKEYHGQGVGKALFEKA 117
Cdd:TIGR01575  10 AAAFAFPWTEAQFAEELANYHLCYLLARIGGKVVGYAgvQIVLDEA----------HILNIAVKPEYQGQGIGRALLREL 79

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2204475704 118 LRIAESGNFSWAWLGVWEKNYKAQHFYKRYGFEKFGEH 155
Cdd:TIGR01575  80 IDEAKGRGVNEIFLEVRVSNIAAQALYKKLGFNEIAIR 117
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
83-159 1.11e-09

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 52.60  E-value: 1.11e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2204475704  83 AQTERKLENAFEVQRLYVLKEYHGQGVGKALFEKALRIAESGNFSWAWLGVWEKNYKAQHFYKRYGFEKFGEHQFVV 159
Cdd:COG3393     6 AGVRAESPGVAEISGVYTHPEYRGRGLASALVAALAREALARGARTPFLYVDADNPAARRLYERLGFRPVGEYATVL 82
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 64-131 1.20e-08

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 49.20  E-value: 1.20e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2204475704  64 YLAYVDDVLAGYLKINWgdaqtERKLENAFEVQRLYVLKEYHGQGVGKALFEKALRIAESGNFSWAWL 131
Cdd:cd04301     2 LVAEDDGEIVGFASLSP-----DGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRL 64
RimL COG1670
Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, ...
 9-154 2.37e-08

Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441276 [Multi-domain]  Cd Length: 173  Bit Score: 50.77  E-value: 2.37e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204475704   9 RAQETDIPALSNLCAD--TFRETFSHDNTEEELQAFFDEAynhdvlkreLDHDESETYLAYV-----DDVLAGYLKINWG 81
Cdd:COG1670    12 PLRPEDAEALAELLNDpeVARYLPGPPYSLEEARAWLERL---------LADWADGGALPFAiedkeDGELIGVVGLYDI 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2204475704  82 DAQTERklenaFEVqRLYVLKEYHGQGVGKALFEKALRIA-ESGNFSWAWLGVWEKNYKAQHFYKRYGFEKFGE 154
Cdd:COG1670    83 DRANRS-----AEI-GYWLAPAYWGKGYATEALRALLDYAfEELGLHRVEAEVDPDNTASIRVLEKLGFRLEGT 150
PRK10514 PRK10514
putative acetyltransferase; Provisional
 98-153 8.37e-05

putative acetyltransferase; Provisional


Pssm-ID: 182510 [Multi-domain]  Cd Length: 145  Bit Score: 40.76  E-value: 8.37e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2204475704  98 LYVLKEYHGQGVGKALFEKALRIAEsgNFSwawLGVWEKNYKAQHFYKRYGFEKFG 153
Cdd:PRK10514   75 LFVDPDVRGCGVGRMLVEHALSLHP--ELT---TDVNEQNEQAVGFYKKMGFKVTG 125
PRK10562 PRK10562
putative acetyltransferase; Provisional
 89-149 2.35e-04

putative acetyltransferase; Provisional


Pssm-ID: 236715 [Multi-domain]  Cd Length: 145  Bit Score: 39.28  E-value: 2.35e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2204475704  89 LENAFeVQRLYVLKEYHGQGVGKALFEKALRiaesgNFSWAWLGVWEKNYKAQHFYKRYGF 149
Cdd:PRK10562   66 LEGRF-VGALFVAPKAVRRGIGKALMQHVQQ-----RYPHLSLEVYQKNQRAVNFYHAQGF 120
PRK07757 PRK07757
N-acetyltransferase;
64-150 5.23e-04

N-acetyltransferase;


Pssm-ID: 236088 [Multi-domain]  Cd Length: 152  Bit Score: 38.64  E-value: 5.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204475704  64 YLAYVDDVLAGY--LKINWgdaqterklENAFEVQRLYVLKEYHGQGVGKALFEKALRIAESgnfswawLGVWEK---NY 138
Cdd:PRK07757   44 YVAEEEGEIVGCcaLHILW---------EDLAEIRSLAVSEDYRGQGIGRMLVEACLEEARE-------LGVKRVfalTY 107

                          90
                  ....*....|..
gi 2204475704 139 KaQHFYKRYGFE 150
Cdd:PRK07757  108 Q-PEFFEKLGFR 118
Spm_actase_Thplmales NF041158
spermidine N(1)-acetyltransferase;
14-120 4.92e-03

spermidine N(1)-acetyltransferase;


Pssm-ID: 469070  Cd Length: 115  Bit Score: 35.29  E-value: 4.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204475704  14 DIPALSNLCADTFRETFSHDNTEEELQAFFDEAYNHDVLKRELDHDESETYL----AYVDDVLAGYLKInwgdaqteRKL 89
Cdd:NF041158   11 DVDALIEVARESWKWTYRDIYSNEFIESWISEKYSKEKLLNEIIRSQSNLDIiflgAFVNSALIGFIEL--------KII 82

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2204475704  90 ENAFEVQRLYVLKEYHGQGVGKALFEKALRI 120
Cdd:NF041158   83 ADKAELLRLYLKPEYTHRGIGKLLLSEAEKI 113
rimI PRK09491
ribosomal-protein-alanine N-acetyltransferase; Provisional
 62-149 6.00e-03

ribosomal-protein-alanine N-acetyltransferase; Provisional


Pssm-ID: 181904 [Multi-domain]  Cd Length: 146  Bit Score: 35.29  E-value: 6.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204475704  62 ETYLAY---VDDVLAGYlkinwgdAQTERKLENA--FEVQrlyVLKEYHGQGVGKALFEKALRIAESGNFSWAWLGVWEK 136
Cdd:PRK09491   38 ERYLNLkltVNGQMAAF-------AITQVVLDEAtlFNIA---VDPDYQRQGLGRALLEHLIDELEKRGVATLWLEVRAS 107

                          90
                  ....*....|...
gi 2204475704 137 NYKAQHFYKRYGF 149
Cdd:PRK09491  108 NAAAIALYESLGF 120
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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