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Conserved domains on  [gi|2205640650|ref|WP_240769184|]
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TIGR03862 family flavoprotein, partial [Paracoccus liaowanqingii]

Protein Classification

NAD(P)/FAD-dependent oxidoreductase( domain architecture ID 11449903)

NAD(P)/FAD-dependent oxidoreductase catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant; similar to Escherichia coli uncharacterized protein YhiN

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YhiN COG2081
Predicted flavoprotein YhiN [General function prediction only];
10-394 7.91e-116

Predicted flavoprotein YhiN [General function prediction only];


:

Pssm-ID: 441684 [Multi-domain]  Cd Length: 402  Bit Score: 343.19  E-value: 7.91e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205640650  10 LVIGAGPAGLMAAEALMAPGRRVVVAEAMPTPARKFLMAGKSGLNLTKAEPLSAFARgiaggsggCLPPDPRgYLWTAAG 89
Cdd:COG2081     1 IVIGAGAAGLMAAITAAERGARVLLLEKNPKVGRKILISGGGRCNFTNSEPLPEFLN--------YYGGNPH-FLKSALS 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205640650  90 EFGPEAVRNWAEGLGIELFTGSTGRVFPVGMKASPLLRAWLARLRAGGVDLRSRWRWVG---MEGGWQFAAPEGpRVLQP 166
Cdd:COG2081    72 RFTPEDLIAFFEGLGIETKEESSGRVFPDSSKASDILRALLAELREAGVEIRLRTRVTGiekEDGGFGVETPDG-ETVRA 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205640650 167 RVTILALGGASWPRLGSDGAWVPMLEVAGVAVAPFRPANMGFRVAwSAPMARVFGAAVKGTAIRAGD---AVSRGEWVIT 243
Cdd:COG2081   151 DAVVLATGGLSYPKLGSTGDGYRLAEQFGHTITPLRPALVPLTLS-EHFFKRLAGLSLKNVALSVGGkkiASFRGELLFT 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205640650 244 QHGIEGGGVYAV-----AAAIRDGAAAVVDLAPDLDHDALAARFAQPR---GRLSLGNWLRRIWgdPARVALTL------ 309
Cdd:COG2081   230 HRGLSGPAILQLssywrDALKKGGATLTIDLLPDLDLEELDARLARPReknGKKSLKNVLRGLL--PKRLAALLleladp 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205640650 310 --EWGQPLPSDPAGWAARAKALPLRHAGPMGL----------------SRaissaggiaaaaltpDLELRARPGVFAAGE 371
Cdd:COG2081   308 dkPLAQLSKKEREALAALLKAWPLTPTGTRGYdeaivtaggvdtkeldPK---------------TMESKKVPGLYFAGE 372

                         410       420
                  ....*....|....*....|...
gi 2205640650 372 MLDWEAPTGGYLLTTCLATGRRA 394
Cdd:COG2081   373 VLDVDGPTGGYNLQWAWSSGYAA 395
 
Name Accession Description Interval E-value
YhiN COG2081
Predicted flavoprotein YhiN [General function prediction only];
10-394 7.91e-116

Predicted flavoprotein YhiN [General function prediction only];


Pssm-ID: 441684 [Multi-domain]  Cd Length: 402  Bit Score: 343.19  E-value: 7.91e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205640650  10 LVIGAGPAGLMAAEALMAPGRRVVVAEAMPTPARKFLMAGKSGLNLTKAEPLSAFARgiaggsggCLPPDPRgYLWTAAG 89
Cdd:COG2081     1 IVIGAGAAGLMAAITAAERGARVLLLEKNPKVGRKILISGGGRCNFTNSEPLPEFLN--------YYGGNPH-FLKSALS 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205640650  90 EFGPEAVRNWAEGLGIELFTGSTGRVFPVGMKASPLLRAWLARLRAGGVDLRSRWRWVG---MEGGWQFAAPEGpRVLQP 166
Cdd:COG2081    72 RFTPEDLIAFFEGLGIETKEESSGRVFPDSSKASDILRALLAELREAGVEIRLRTRVTGiekEDGGFGVETPDG-ETVRA 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205640650 167 RVTILALGGASWPRLGSDGAWVPMLEVAGVAVAPFRPANMGFRVAwSAPMARVFGAAVKGTAIRAGD---AVSRGEWVIT 243
Cdd:COG2081   151 DAVVLATGGLSYPKLGSTGDGYRLAEQFGHTITPLRPALVPLTLS-EHFFKRLAGLSLKNVALSVGGkkiASFRGELLFT 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205640650 244 QHGIEGGGVYAV-----AAAIRDGAAAVVDLAPDLDHDALAARFAQPR---GRLSLGNWLRRIWgdPARVALTL------ 309
Cdd:COG2081   230 HRGLSGPAILQLssywrDALKKGGATLTIDLLPDLDLEELDARLARPReknGKKSLKNVLRGLL--PKRLAALLleladp 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205640650 310 --EWGQPLPSDPAGWAARAKALPLRHAGPMGL----------------SRaissaggiaaaaltpDLELRARPGVFAAGE 371
Cdd:COG2081   308 dkPLAQLSKKEREALAALLKAWPLTPTGTRGYdeaivtaggvdtkeldPK---------------TMESKKVPGLYFAGE 372

                         410       420
                  ....*....|....*....|...
gi 2205640650 372 MLDWEAPTGGYLLTTCLATGRRA 394
Cdd:COG2081   373 VLDVDGPTGGYNLQWAWSSGYAA 395
flavo_PP4765 TIGR03862
uncharacterized flavoprotein, PP_4765 family; This model describes a sharply distinctive clade ...
 29-394 1.32e-114

uncharacterized flavoprotein, PP_4765 family; This model describes a sharply distinctive clade of proteins within the larger family of flavoproteins described by pfam03486 and TIGRFAMs model TIGR00275. The function is unknown.


Pssm-ID: 274820  Cd Length: 376  Bit Score: 339.11  E-value: 1.32e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205640650  29 GRRVVVAEAMPTPARKFLMAGKSGLNLTKAEPLSAFARGIAggsggclppDPRGYLWTAAGEFGPEAVRNWAEGLGIELF 108
Cdd:TIGR03862   1 GLEVDVFEAKPSVGRKFLMAGKSGLNLTHSEPLPRFIERYG---------DAAEWLAPWLEAFDAVALQDWARGLGIETF 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205640650 109 TGSTGRVFPVGMKASPLLRAWLARLRAGGVDLRSRWRWVGMEGG-WQFAAPEGPRVLQPRVTILALGGASWPRLGSDGAW 187
Cdd:TIGR03862  72 VGSSGRVFPVEMKAAPLLRAWLKRLAEQGVQFHTRHRWIGWQGGtLRFETPDGQSTIEADAVVLALGGASWSQLGSDGAW 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205640650 188 VPMLEVAGVAVAPFRPANMGFRVAWSAPMARVF-GAAVKGTAIRAGDAVSRGEWVITQHGIEGGGVYAVAA------AIR 260
Cdd:TIGR03862 152 QQVLDQRGVSVAPFAPANCGFLVDWSAHFASRFaGEPLKRVNATAGTQQTRGEIVITARGLEGGLIYALSAalreqiKAG 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205640650 261 DGAAAVVDLAPDLDHDALAARFAQPRGRLSLGNWLRRIWG-DPARVALTLE-WGQPLPSDPAGWAARAKALPLRHAGPMG 338
Cdd:TIGR03862 232 GSANLFLDLLPDLSLEQVTKRLAAPRGKQSLSNHLRKALGlDGVKRALLREvFPKAAWSQPETLAQTIKALPLPLDGTRP 311

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2205640650 339 LSRAISSAGGIAAAALTPDLELRARPGVFAAGEMLDWEAPTGGYLLTTCLATGRRA 394
Cdd:TIGR03862 312 IDEAISTAGGVRQDALDESLMLKARPGVFCAGEMLDWEAPTGGYLLTACFATGRAA 367
HI0933_like pfam03486
HI0933-like protein;
8-394 3.37e-91

HI0933-like protein;


Pssm-ID: 427330 [Multi-domain]  Cd Length: 406  Bit Score: 280.24  E-value: 3.37e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205640650   8 DALVIGAGPAGLMAAEALMAPGRRVVVAEAMPTPARKFLMAGKSGLNLT-KAEPLSAFARGIAGGSGGCLPpdprgylwt 86
Cdd:pfam03486   2 DVIVIGGGAAGLMAAISAAKRGRRVLLIEKGKKLGRKILISGGGRCNVTnLSEEPDNFLSRYPGNPKFLKS--------- 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205640650  87 AAGEFGPEAVRNWAEGLGIELFTGSTGRVFPVGMKASPLLRAWLARLRAGGVDLRSRWRWVGME----GGWQFAAPEGPr 162
Cdd:pfam03486  73 ALSRFTPWDFIAFFESLGVPLKEEDHGRLFPDSDKASDIVDALLNELKELGVKIRLRTRVLSVEkdddGRFRVKTGGEE- 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205640650 163 vLQPRVTILALGGASWPRLGSDGAWVPMLEVAGVAVAPFRPANMGFRVAWSA-PMARVFGAAVKGTA--IRAGDAVSRGE 239
Cdd:pfam03486 152 -LEADSLVLATGGLSWPKTGSTGFGYPLAEQFGHTIIPLRPALVPFTIDEPFlFLKRLSGISLKNVVlsNGKGGITFRGE 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205640650 240 WVITQHGIEGGGVYAVAAAIRDGAAA------VVDLAPDLDHDALAARFAQPRG---RLSLGNWL-----RRIWGDPARV 305
Cdd:pfam03486 231 LLFTHRGLSGPAILQLSSYWRRAILKkggvtlSIDLLPDLDAEELAARLEKPRGahpKKSLKNSLagllpKRLAEFLLEQ 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205640650 306 AL---TLEWGQPLPSDPAGWAARAKALPLRHAGPMGLSRAISSAGGIAAAALTPD-LELRARPGVFAAGEMLDWEAPTGG 381
Cdd:pfam03486 311 AGiepDKKLAQLSKKELAALAQLLKAWTFTPNGTEGYRTAEVTAGGVDTKELSSKtMESKKVPGLFFAGEVLDVDGWTGG 390

                         410
                  ....*....|...
gi 2205640650 382 YLLTTCLATGRRA 394
Cdd:pfam03486 391 YNLQWAWSSGYAA 403
PRK07208 PRK07208
hypothetical protein; Provisional
 3-40 1.96e-04

hypothetical protein; Provisional


Pssm-ID: 235967 [Multi-domain]  Cd Length: 479  Bit Score: 43.34  E-value: 1.96e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2205640650   3 DPEVVDALVIGAGPAGLMAAEALMAPGRRVVVAEAMPT 40
Cdd:PRK07208    1 MTNKKSVVIIGAGPAGLTAAYELLKRGYPVTVLEADPV 38
butanediol_DH_like cd08233
(2R,3R)-2,3-butanediol dehydrogenase; (2R,3R)-2,3-butanediol dehydrogenase, a zinc-dependent ...
 9-73 7.99e-03

(2R,3R)-2,3-butanediol dehydrogenase; (2R,3R)-2,3-butanediol dehydrogenase, a zinc-dependent medium chain alcohol dehydrogenase, catalyzes the NAD(+)-dependent oxidation of (2R,3R)-2,3-butanediol and meso-butanediol to acetoin. BDH functions as a homodimer. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. The medium chain alcohol dehydrogenase family (MDR) have a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit. Sorbitol and aldose reductase are NAD(+) binding proteins of the polyol pathway, which interconverts glucose and fructose. Sorbitol dehydrogenase is tetrameric and has a single catalytic zinc per subunit.


Pssm-ID: 176195 [Multi-domain]  Cd Length: 351  Bit Score: 37.91  E-value: 7.99e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2205640650   9 ALVIGAGPAGLMAAEALMAPG-RRVVVAEamPTPARKfLMAGKSGLNLT---KAEPLSAFARGIAGGSG 73
Cdd:cd08233   176 ALVLGAGPIGLLTILALKAAGaSKIIVSE--PSEARR-ELAEELGATIVldpTEVDVVAEVRKLTGGGG 241
 
Name Accession Description Interval E-value
YhiN COG2081
Predicted flavoprotein YhiN [General function prediction only];
10-394 7.91e-116

Predicted flavoprotein YhiN [General function prediction only];


Pssm-ID: 441684 [Multi-domain]  Cd Length: 402  Bit Score: 343.19  E-value: 7.91e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205640650  10 LVIGAGPAGLMAAEALMAPGRRVVVAEAMPTPARKFLMAGKSGLNLTKAEPLSAFARgiaggsggCLPPDPRgYLWTAAG 89
Cdd:COG2081     1 IVIGAGAAGLMAAITAAERGARVLLLEKNPKVGRKILISGGGRCNFTNSEPLPEFLN--------YYGGNPH-FLKSALS 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205640650  90 EFGPEAVRNWAEGLGIELFTGSTGRVFPVGMKASPLLRAWLARLRAGGVDLRSRWRWVG---MEGGWQFAAPEGpRVLQP 166
Cdd:COG2081    72 RFTPEDLIAFFEGLGIETKEESSGRVFPDSSKASDILRALLAELREAGVEIRLRTRVTGiekEDGGFGVETPDG-ETVRA 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205640650 167 RVTILALGGASWPRLGSDGAWVPMLEVAGVAVAPFRPANMGFRVAwSAPMARVFGAAVKGTAIRAGD---AVSRGEWVIT 243
Cdd:COG2081   151 DAVVLATGGLSYPKLGSTGDGYRLAEQFGHTITPLRPALVPLTLS-EHFFKRLAGLSLKNVALSVGGkkiASFRGELLFT 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205640650 244 QHGIEGGGVYAV-----AAAIRDGAAAVVDLAPDLDHDALAARFAQPR---GRLSLGNWLRRIWgdPARVALTL------ 309
Cdd:COG2081   230 HRGLSGPAILQLssywrDALKKGGATLTIDLLPDLDLEELDARLARPReknGKKSLKNVLRGLL--PKRLAALLleladp 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205640650 310 --EWGQPLPSDPAGWAARAKALPLRHAGPMGL----------------SRaissaggiaaaaltpDLELRARPGVFAAGE 371
Cdd:COG2081   308 dkPLAQLSKKEREALAALLKAWPLTPTGTRGYdeaivtaggvdtkeldPK---------------TMESKKVPGLYFAGE 372

                         410       420
                  ....*....|....*....|...
gi 2205640650 372 MLDWEAPTGGYLLTTCLATGRRA 394
Cdd:COG2081   373 VLDVDGPTGGYNLQWAWSSGYAA 395
flavo_PP4765 TIGR03862
uncharacterized flavoprotein, PP_4765 family; This model describes a sharply distinctive clade ...
 29-394 1.32e-114

uncharacterized flavoprotein, PP_4765 family; This model describes a sharply distinctive clade of proteins within the larger family of flavoproteins described by pfam03486 and TIGRFAMs model TIGR00275. The function is unknown.


Pssm-ID: 274820  Cd Length: 376  Bit Score: 339.11  E-value: 1.32e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205640650  29 GRRVVVAEAMPTPARKFLMAGKSGLNLTKAEPLSAFARGIAggsggclppDPRGYLWTAAGEFGPEAVRNWAEGLGIELF 108
Cdd:TIGR03862   1 GLEVDVFEAKPSVGRKFLMAGKSGLNLTHSEPLPRFIERYG---------DAAEWLAPWLEAFDAVALQDWARGLGIETF 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205640650 109 TGSTGRVFPVGMKASPLLRAWLARLRAGGVDLRSRWRWVGMEGG-WQFAAPEGPRVLQPRVTILALGGASWPRLGSDGAW 187
Cdd:TIGR03862  72 VGSSGRVFPVEMKAAPLLRAWLKRLAEQGVQFHTRHRWIGWQGGtLRFETPDGQSTIEADAVVLALGGASWSQLGSDGAW 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205640650 188 VPMLEVAGVAVAPFRPANMGFRVAWSAPMARVF-GAAVKGTAIRAGDAVSRGEWVITQHGIEGGGVYAVAA------AIR 260
Cdd:TIGR03862 152 QQVLDQRGVSVAPFAPANCGFLVDWSAHFASRFaGEPLKRVNATAGTQQTRGEIVITARGLEGGLIYALSAalreqiKAG 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205640650 261 DGAAAVVDLAPDLDHDALAARFAQPRGRLSLGNWLRRIWG-DPARVALTLE-WGQPLPSDPAGWAARAKALPLRHAGPMG 338
Cdd:TIGR03862 232 GSANLFLDLLPDLSLEQVTKRLAAPRGKQSLSNHLRKALGlDGVKRALLREvFPKAAWSQPETLAQTIKALPLPLDGTRP 311

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2205640650 339 LSRAISSAGGIAAAALTPDLELRARPGVFAAGEMLDWEAPTGGYLLTTCLATGRRA 394
Cdd:TIGR03862 312 IDEAISTAGGVRQDALDESLMLKARPGVFCAGEMLDWEAPTGGYLLTACFATGRAA 367
HI0933_like pfam03486
HI0933-like protein;
8-394 3.37e-91

HI0933-like protein;


Pssm-ID: 427330 [Multi-domain]  Cd Length: 406  Bit Score: 280.24  E-value: 3.37e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205640650   8 DALVIGAGPAGLMAAEALMAPGRRVVVAEAMPTPARKFLMAGKSGLNLT-KAEPLSAFARGIAGGSGGCLPpdprgylwt 86
Cdd:pfam03486   2 DVIVIGGGAAGLMAAISAAKRGRRVLLIEKGKKLGRKILISGGGRCNVTnLSEEPDNFLSRYPGNPKFLKS--------- 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205640650  87 AAGEFGPEAVRNWAEGLGIELFTGSTGRVFPVGMKASPLLRAWLARLRAGGVDLRSRWRWVGME----GGWQFAAPEGPr 162
Cdd:pfam03486  73 ALSRFTPWDFIAFFESLGVPLKEEDHGRLFPDSDKASDIVDALLNELKELGVKIRLRTRVLSVEkdddGRFRVKTGGEE- 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205640650 163 vLQPRVTILALGGASWPRLGSDGAWVPMLEVAGVAVAPFRPANMGFRVAWSA-PMARVFGAAVKGTA--IRAGDAVSRGE 239
Cdd:pfam03486 152 -LEADSLVLATGGLSWPKTGSTGFGYPLAEQFGHTIIPLRPALVPFTIDEPFlFLKRLSGISLKNVVlsNGKGGITFRGE 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205640650 240 WVITQHGIEGGGVYAVAAAIRDGAAA------VVDLAPDLDHDALAARFAQPRG---RLSLGNWL-----RRIWGDPARV 305
Cdd:pfam03486 231 LLFTHRGLSGPAILQLSSYWRRAILKkggvtlSIDLLPDLDAEELAARLEKPRGahpKKSLKNSLagllpKRLAEFLLEQ 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205640650 306 AL---TLEWGQPLPSDPAGWAARAKALPLRHAGPMGLSRAISSAGGIAAAALTPD-LELRARPGVFAAGEMLDWEAPTGG 381
Cdd:pfam03486 311 AGiepDKKLAQLSKKELAALAQLLKAWTFTPNGTEGYRTAEVTAGGVDTKELSSKtMESKKVPGLFFAGEVLDVDGWTGG 390

                         410
                  ....*....|...
gi 2205640650 382 YLLTTCLATGRRA 394
Cdd:pfam03486 391 YNLQWAWSSGYAA 403
TIGR00275 TIGR00275
flavoprotein, HI0933 family; The model when searched with a partial length search brings in ...
 10-394 1.69e-71

flavoprotein, HI0933 family; The model when searched with a partial length search brings in proteins with a dinucleotide-binding motif (Rossman fold) over the initial 40 residues of the model, including oxidoreductases and dehydrogenases. Partially characterized members include an FAD-binding protein from Bacillus cereus and flavoprotein HI0933 from Haemophilus influenzae. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 272992 [Multi-domain]  Cd Length: 400  Bit Score: 229.41  E-value: 1.69e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205640650  10 LVIGAGPAGLMAAEALMAPGRRVVVAEAMPTPARKFLMAGKSGLNLTKAEPLSAFARGIaggsggclpPDPRGYLWTAAG 89
Cdd:TIGR00275   1 IIIGGGAAGLMAAITAARAGLSVLLLEKNKKIGKKLLISGGGRCNLTNSCPTPEFVAYY---------PRNGKFLRSALS 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205640650  90 EFGPEAVRNWAEGLGIELFTGSTGRVFPVGMKASPLLRAWLARLRAGGVDLRSRWRWVGME-GGWQFAAPEGPRVLQPRV 168
Cdd:TIGR00275  72 RFSNKDLIDFFESLGLELKVEEDGRVFPCSDSAADVLDALLNELKELGVEILTNSKVKSIEkEDGGFGVETSGGEYEADK 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205640650 169 TILALGGASWPRLGSDGAWVPMLEVAGVAVAPFRPANMGFRVAWSApMARVFGAAVKGTAIRAGDAVS----RGEWVITQ 244
Cdd:TIGR00275 152 VIIATGGLSYPQLGSTGDGYEIAESLGHTIVPPVPALVPLTLDESF-LKELSGISLDGVVLSLVNGKKvleeFGELLFTH 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205640650 245 HGIEGGGV-----YAVAAAIRDGAAAV-VDLAPDLDHDALAARFAQPRG-------RLSLGNWL-RRIWgdparvALTLE 310
Cdd:TIGR00275 231 FGLSGPAIldlsaFAARALLKHKGVELeIDLLPDLSEEELEQRLKRLRKsnpkktvKNILKGLLpKRLA------ELLLE 304

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205640650 311 WGQPLPSDPAG---WAARA------KALPLRHAGPMGLSRAISSAGGIAAAALTPD-LELRARPGVFAAGEMLDWEAPTG 380
Cdd:TIGR00275 305 QLGIDPDLPAAqlsKKEIKklvqllKNWPFTISGTRGFKEAEVTAGGVSLKEINPKtMESKLVPGLYFAGEVLDIDGDTG 384

                         410
                  ....*....|....
gi 2205640650 381 GYLLTTCLATGRRA 394
Cdd:TIGR00275 385 GYNLQWAWSSGYLA 398
FadH2 COG0446
NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase ...
 1-45 1.71e-04

NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism];


Pssm-ID: 440215 [Multi-domain]  Cd Length: 322  Bit Score: 43.26  E-value: 1.71e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2205640650   1 MSDPEVVDALVIGAGPAGLMAAEALMAPGRRVVVAEAMPTPARKF 45
Cdd:COG0446   119 LKEFKGKRAVVIGGGPIGLELAEALRKRGLKVTLVERAPRLLGVL 163
PRK07208 PRK07208
hypothetical protein; Provisional
 3-40 1.96e-04

hypothetical protein; Provisional


Pssm-ID: 235967 [Multi-domain]  Cd Length: 479  Bit Score: 43.34  E-value: 1.96e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2205640650   3 DPEVVDALVIGAGPAGLMAAEALMAPGRRVVVAEAMPT 40
Cdd:PRK07208    1 MTNKKSVVIIGAGPAGLTAAYELLKRGYPVTVLEADPV 38
mnmC PRK01747
bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent ...
 8-43 2.85e-04

bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC;


Pssm-ID: 234978 [Multi-domain]  Cd Length: 662  Bit Score: 42.91  E-value: 2.85e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2205640650   8 DALVIGAGPAGLMAAEALMAPGRRVVVAEAMPTPAR 43
Cdd:PRK01747  262 DAAIIGGGIAGAALALALARRGWQVTLYEADEAPAQ 297
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
7-37 4.29e-04

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 42.22  E-value: 4.29e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 2205640650   7 VDALVIGAGPAGLMAAEALMAPGRRVVVAEA 37
Cdd:COG1231     8 KDVVIVGAGLAGLAAARELRKAGLDVTVLEA 38
PRK07494 PRK07494
UbiH/UbiF family hydroxylase;
1-42 1.17e-03

UbiH/UbiF family hydroxylase;


Pssm-ID: 181001 [Multi-domain]  Cd Length: 388  Bit Score: 40.66  E-value: 1.17e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2205640650   1 MSDPEVVDALVIGAGPAGLMAAEALMAPGRRVVVAEAMPTPA 42
Cdd:PRK07494    2 LMEKEHTDIAVIGGGPAGLAAAIALARAGASVALVAPEPPYA 43
PRK06292 PRK06292
dihydrolipoamide dehydrogenase; Validated
 7-36 1.83e-03

dihydrolipoamide dehydrogenase; Validated


Pssm-ID: 235774 [Multi-domain]  Cd Length: 460  Bit Score: 40.16  E-value: 1.83e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 2205640650   7 VDALVIGAGPAGLMAAEALMAPGRRVVVAE 36
Cdd:PRK06292    4 YDVIVIGAGPAGYVAARRAAKLGKKVALIE 33
PRK12814 PRK12814
putative NADPH-dependent glutamate synthase small subunit; Provisional
 11-41 3.04e-03

putative NADPH-dependent glutamate synthase small subunit; Provisional


Pssm-ID: 139246 [Multi-domain]  Cd Length: 652  Bit Score: 39.71  E-value: 3.04e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 2205640650  11 VIGAGPAGLMAAEALMAPGRRVVVAEAMPTP 41
Cdd:PRK12814  198 IIGAGPAGLTAAYYLLRKGHDVTIFDANEQA 228
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 7-37 3.07e-03

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 39.43  E-value: 3.07e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 2205640650   7 VDALVIGAGPAGLMAAEALMAPGRRVVVAEA 37
Cdd:COG1232     2 KRVAVIGGGIAGLTAAYRLAKAGHEVTVLEA 32
PRK07233 PRK07233
hypothetical protein; Provisional
 11-41 3.40e-03

hypothetical protein; Provisional


Pssm-ID: 235977 [Multi-domain]  Cd Length: 434  Bit Score: 39.48  E-value: 3.40e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 2205640650  11 VIGAGPAGLMAAEALMAPGRRVVVAEAMPTP 41
Cdd:PRK07233    4 IVGGGIAGLAAAYRLAKRGHEVTVFEADDQL 34
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 2-37 3.75e-03

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 39.08  E-value: 3.75e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2205640650   2 SDPEVVDALVIGAGPAGLMAAEALMAPGRRVVVAEA 37
Cdd:COG2072     2 AATEHVDVVVIGAGQAGLAAAYHLRRAGIDFVVLEK 37
COG2509 COG2509
FAD-dependent dehydrogenase [General function prediction only];
8-36 5.45e-03

FAD-dependent dehydrogenase [General function prediction only];


Pssm-ID: 441999 [Multi-domain]  Cd Length: 466  Bit Score: 38.56  E-value: 5.45e-03
                          10        20
                  ....*....|....*....|....*....
gi 2205640650   8 DALVIGAGPAGLMAAEALMAPGRRVVVAE 36
Cdd:COG2509    32 DVVIVGAGPAGLFAALELAEAGLKPLVLE 60
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
7-141 5.81e-03

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 38.35  E-value: 5.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205640650   7 VDALVIGAGPAGLMAAEALMAPGRRVVVAEAmptparkflmagksglnltkaeplSAFARGIAGGSGGCLPP---DPRGY 83
Cdd:COG0665     3 ADVVVIGGGIAGLSTAYHLARRGLDVTVLER------------------------GRPGSGASGRNAGQLRPglaALADR 58

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2205640650  84 LWTAAGEFGPEAVRNWAEGLGIELFTGSTGRVFPVGMKASP-LLRAWLARLRAGGVDLR 141
Cdd:COG0665    59 ALVRLAREALDLWRELAAELGIDCDFRRTGVLYLARTEAELaALRAEAEALRALGLPVE 117
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 8-141 6.61e-03

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 38.15  E-value: 6.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205640650   8 DALVIGAGPAGLMAAEALMAPGRRVVVAEAMPTParkflmagksglnltkaeplsafARGIAGGSGGCLPPDPRGYLWTA 87
Cdd:pfam01266   1 DVVVIGGGIVGLSTAYELARRGLSVTLLERGDDP-----------------------GSGASGRNAGLIHPGLRYLEPSE 57

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2205640650  88 AGEFGPEAVRNWAE---GLGIELFTGSTGRVFPVGMKASPLLRAWLARLRAGGVDLR 141
Cdd:pfam01266  58 LARLALEALDLWEEleeELGIDCGFRRCGVLVLARDEEEEALEKLLAALRRLGVPAE 114
GltD COG0493
NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport ...
 11-41 7.26e-03

NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]; NADPH-dependent glutamate synthase beta chain or related oxidoreductase is part of the Pathway/BioSystem: Glutamine biosynthesis


Pssm-ID: 440259 [Multi-domain]  Cd Length: 434  Bit Score: 38.19  E-value: 7.26e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 2205640650  11 VIGAGPAGLMAAEALMAPGRRVVVAEAMPTP 41
Cdd:COG0493   126 VVGSGPAGLAAAYQLARAGHEVTVFEALDKP 156
butanediol_DH_like cd08233
(2R,3R)-2,3-butanediol dehydrogenase; (2R,3R)-2,3-butanediol dehydrogenase, a zinc-dependent ...
 9-73 7.99e-03

(2R,3R)-2,3-butanediol dehydrogenase; (2R,3R)-2,3-butanediol dehydrogenase, a zinc-dependent medium chain alcohol dehydrogenase, catalyzes the NAD(+)-dependent oxidation of (2R,3R)-2,3-butanediol and meso-butanediol to acetoin. BDH functions as a homodimer. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. The medium chain alcohol dehydrogenase family (MDR) have a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit. Sorbitol and aldose reductase are NAD(+) binding proteins of the polyol pathway, which interconverts glucose and fructose. Sorbitol dehydrogenase is tetrameric and has a single catalytic zinc per subunit.


Pssm-ID: 176195 [Multi-domain]  Cd Length: 351  Bit Score: 37.91  E-value: 7.99e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2205640650   9 ALVIGAGPAGLMAAEALMAPG-RRVVVAEamPTPARKfLMAGKSGLNLT---KAEPLSAFARGIAGGSG 73
Cdd:cd08233   176 ALVLGAGPIGLLTILALKAAGaSKIIVSE--PSEARR-ELAEELGATIVldpTEVDVVAEVRKLTGGGG 241
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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