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Conserved domains on  [gi|2208448108|ref|WP_241429723|]
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MULTISPECIES: sigma-E factor negative regulatory protein [Neisseria]

Protein Classification

sigma-E factor negative regulatory protein( domain architecture ID 11611353)

sigma-E factor negative regulatory protein similar to anti-sigma-E factor RseA that functions as the anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE); ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RseA_N cd16328
N-terminal domain of RseA; This family contains the cytoplasmic (N-terminal) domain of RseA, ...
 5-68 2.74e-13

N-terminal domain of RseA; This family contains the cytoplasmic (N-terminal) domain of RseA, the transmembrane anti-sigma-E factor. RseA is degraded during sigma-E-dependent transcription caused by bacterial envelope stress such as heat shock. It is an inner membrane protein with an N-terminal cytoplasmic domain that binds sigma-E and blocks its transcriptional activity, and a C-terminal periplasmic domain that binds RseB, an auxiliary negative regulator. Under inducing conditions, RseA is rapidly degraded and sigma-E is released into the cytoplasm, where it can bind core RNAP and induce its regulon. It has been shown that just the N-terminal domain is sufficient to bind and inhibit sigma-E. The C-terminal domain may interact with other proteins that signal periplasmic stress.


:

Pssm-ID: 319992  Cd Length: 65  Bit Score: 61.82  E-value: 2.74e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2208448108   5 REYVSMLMDGDQVSEE---MLDRLLSDDAAAEAWYEYHLLGDCMRYKEGTGRDADFmqSAAFTATLA 68
Cdd:cd16328     1 KEQLSALMDGELDELEldrLLADLDSDPELRATWQRYHLIGDVLRGELLAAASADF--AARVAAALA 65
 
Name Accession Description Interval E-value
RseA_N cd16328
N-terminal domain of RseA; This family contains the cytoplasmic (N-terminal) domain of RseA, ...
 5-68 2.74e-13

N-terminal domain of RseA; This family contains the cytoplasmic (N-terminal) domain of RseA, the transmembrane anti-sigma-E factor. RseA is degraded during sigma-E-dependent transcription caused by bacterial envelope stress such as heat shock. It is an inner membrane protein with an N-terminal cytoplasmic domain that binds sigma-E and blocks its transcriptional activity, and a C-terminal periplasmic domain that binds RseB, an auxiliary negative regulator. Under inducing conditions, RseA is rapidly degraded and sigma-E is released into the cytoplasm, where it can bind core RNAP and induce its regulon. It has been shown that just the N-terminal domain is sufficient to bind and inhibit sigma-E. The C-terminal domain may interact with other proteins that signal periplasmic stress.


Pssm-ID: 319992  Cd Length: 65  Bit Score: 61.82  E-value: 2.74e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2208448108   5 REYVSMLMDGDQVSEE---MLDRLLSDDAAAEAWYEYHLLGDCMRYKEGTGRDADFmqSAAFTATLA 68
Cdd:cd16328     1 KEQLSALMDGELDELEldrLLADLDSDPELRATWQRYHLIGDVLRGELLAAASADF--AARVAAALA 65
RseA_N pfam03872
Anti sigma-E protein RseA, N-terminal domain; Sigma-E is important for the induction of ...
 4-95 4.99e-09

Anti sigma-E protein RseA, N-terminal domain; Sigma-E is important for the induction of proteins involved in heat shock response. RseA binds sigma-E via its N-terminal domain, sequestering sigma-E and preventing transcription from heat-shock promoters. The C-terminal domain is located in the periplasm, and may interact with other protein that signal periplasmic stress.


Pssm-ID: 427557  Cd Length: 87  Bit Score: 51.11  E-value: 4.99e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2208448108   4 TREYVSMLMDGDQVSEEMLDRLLSDDAAAEAWYEYHLLGDCMRYKEGTGRDADFmqSAAFTATLAeiSEEHKQrheaeva 83
Cdd:pfam03872   2 QKEQLSALMDGELLDSELLNALSQDAELQQTWARYHLIRDVLRGELPVVLGADI--AARVAAALE--DEPVHL------- 70

                          90
                  ....*....|..
gi 2208448108  84 aVMPVVKEVQAA 95
Cdd:pfam03872  71 -VPRVAPESQPA 81
RseA COG3073
RseA, negative regulator of sigma E activity [Signal transduction mechanisms];
2-109 2.94e-08

RseA, negative regulator of sigma E activity [Signal transduction mechanisms];


Pssm-ID: 442307  Cd Length: 166  Bit Score: 50.75  E-value: 2.94e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2208448108   2 DTTREYVSMLMDG---DQVSEEMLDRLLSDDAAAEAWYEYHLLGDCMRYKEGTGRDADFmqSAAFTATLaeiseehkqrh 78
Cdd:COG3073     3 EMQKEQLSALMDGeldELEDRRLLDALAQDAELRQTWARYHLIGDVLRGELLAVLSLDF--AARVAAAL----------- 69

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2208448108  79 EAEVAAVMPVVKEVQAANSSFFKSFAVAASV 109
Cdd:COG3073    70 ADEPTVLAPAAAPEARKLRRWLRPLGQVAVA 100
PRK10863 PRK10863
anti-sigma-E factor RseA;
5-46 1.69e-04

anti-sigma-E factor RseA;


Pssm-ID: 182789  Cd Length: 216  Bit Score: 40.81  E-value: 1.69e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2208448108   5 REYVSMLMDGDQVSEEMLDRLLSDDAAAEAWYEYHLLGDCMR 46
Cdd:PRK10863    3 KEKLSALMDGETLDSELLNALSHDPEMQKTWESYHLIRDTLR 44
 
Name Accession Description Interval E-value
RseA_N cd16328
N-terminal domain of RseA; This family contains the cytoplasmic (N-terminal) domain of RseA, ...
 5-68 2.74e-13

N-terminal domain of RseA; This family contains the cytoplasmic (N-terminal) domain of RseA, the transmembrane anti-sigma-E factor. RseA is degraded during sigma-E-dependent transcription caused by bacterial envelope stress such as heat shock. It is an inner membrane protein with an N-terminal cytoplasmic domain that binds sigma-E and blocks its transcriptional activity, and a C-terminal periplasmic domain that binds RseB, an auxiliary negative regulator. Under inducing conditions, RseA is rapidly degraded and sigma-E is released into the cytoplasm, where it can bind core RNAP and induce its regulon. It has been shown that just the N-terminal domain is sufficient to bind and inhibit sigma-E. The C-terminal domain may interact with other proteins that signal periplasmic stress.


Pssm-ID: 319992  Cd Length: 65  Bit Score: 61.82  E-value: 2.74e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2208448108   5 REYVSMLMDGDQVSEE---MLDRLLSDDAAAEAWYEYHLLGDCMRYKEGTGRDADFmqSAAFTATLA 68
Cdd:cd16328     1 KEQLSALMDGELDELEldrLLADLDSDPELRATWQRYHLIGDVLRGELLAAASADF--AARVAAALA 65
RseA_N pfam03872
Anti sigma-E protein RseA, N-terminal domain; Sigma-E is important for the induction of ...
 4-95 4.99e-09

Anti sigma-E protein RseA, N-terminal domain; Sigma-E is important for the induction of proteins involved in heat shock response. RseA binds sigma-E via its N-terminal domain, sequestering sigma-E and preventing transcription from heat-shock promoters. The C-terminal domain is located in the periplasm, and may interact with other protein that signal periplasmic stress.


Pssm-ID: 427557  Cd Length: 87  Bit Score: 51.11  E-value: 4.99e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2208448108   4 TREYVSMLMDGDQVSEEMLDRLLSDDAAAEAWYEYHLLGDCMRYKEGTGRDADFmqSAAFTATLAeiSEEHKQrheaeva 83
Cdd:pfam03872   2 QKEQLSALMDGELLDSELLNALSQDAELQQTWARYHLIRDVLRGELPVVLGADI--AARVAAALE--DEPVHL------- 70

                          90
                  ....*....|..
gi 2208448108  84 aVMPVVKEVQAA 95
Cdd:pfam03872  71 -VPRVAPESQPA 81
RseA COG3073
RseA, negative regulator of sigma E activity [Signal transduction mechanisms];
2-109 2.94e-08

RseA, negative regulator of sigma E activity [Signal transduction mechanisms];


Pssm-ID: 442307  Cd Length: 166  Bit Score: 50.75  E-value: 2.94e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2208448108   2 DTTREYVSMLMDG---DQVSEEMLDRLLSDDAAAEAWYEYHLLGDCMRYKEGTGRDADFmqSAAFTATLaeiseehkqrh 78
Cdd:COG3073     3 EMQKEQLSALMDGeldELEDRRLLDALAQDAELRQTWARYHLIGDVLRGELLAVLSLDF--AARVAAAL----------- 69

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2208448108  79 EAEVAAVMPVVKEVQAANSSFFKSFAVAASV 109
Cdd:COG3073    70 ADEPTVLAPAAAPEARKLRRWLRPLGQVAVA 100
PRK10863 PRK10863
anti-sigma-E factor RseA;
5-46 1.69e-04

anti-sigma-E factor RseA;


Pssm-ID: 182789  Cd Length: 216  Bit Score: 40.81  E-value: 1.69e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2208448108   5 REYVSMLMDGDQVSEEMLDRLLSDDAAAEAWYEYHLLGDCMR 46
Cdd:PRK10863    3 KEKLSALMDGETLDSELLNALSHDPEMQKTWESYHLIRDTLR 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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