NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2211962190|ref|WP_242256308|]
View 

MULTISPECIES: iron ABC transporter permease [Bacillus]

Protein Classification

FecCD family ABC transporter permease( domain architecture ID 10001816)

FecCD family ABC transporter permease such as iron ABC transporter permease, which is the transmembrane subunit (TM) found in a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter involved in the import of iron and iron-containing compounds

CATH:  1.10.3470.10
Gene Ontology:  GO:0140359|GO:0042626
PubMed:  25750732|24638992
SCOP:  4002900
TCDB:  3.A.1

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 30-338 2.29e-97

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


:

Pssm-ID: 440374  Cd Length: 306  Bit Score: 290.43  E-value: 2.29e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190  30 SLNTGTLSIAPLKVIQTLFGY-GDFESATVLYDYRMPRIIITMLAGIGLGVSGAILQGLSRNALADPGILGLHAGASFGL 108
Cdd:COG0609     1 SLSLGAVPISLSDVLRALLGPdGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190 109 ILFVTFFHSInenASILIPLFTFGGGVLAAFLIILLASdRSKGLLPIRLILVGIAVSAGFSAISLFFSLKLNDETYIFAS 188
Cdd:COG0609    81 VLAIVLGGGL---SALGLPLAAFLGALLAALLVYLLAR-RGGGLSPLRLVLAGVAVSALFSALTSLLLLLADPEQLRSIV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190 189 KWLVGNVWGRDWIHVLALLPWIFILTPYAWLKSKTLNALSLGDSVAAGLGVSVQKERLLLLATAVGLSCASVSMAGGIGF 268
Cdd:COG0609   157 FWLMGSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGF 236

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190 269 IGLVAPHIARKLVGTTYQHFLPLAGIIGMIILVLADTIGRSIFEPNSIPAGVVVAALGAPYFLYLLTKTK 338
Cdd:COG0609   237 VGLVVPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRRR 306
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 30-338 2.29e-97

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 290.43  E-value: 2.29e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190  30 SLNTGTLSIAPLKVIQTLFGY-GDFESATVLYDYRMPRIIITMLAGIGLGVSGAILQGLSRNALADPGILGLHAGASFGL 108
Cdd:COG0609     1 SLSLGAVPISLSDVLRALLGPdGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190 109 ILFVTFFHSInenASILIPLFTFGGGVLAAFLIILLASdRSKGLLPIRLILVGIAVSAGFSAISLFFSLKLNDETYIFAS 188
Cdd:COG0609    81 VLAIVLGGGL---SALGLPLAAFLGALLAALLVYLLAR-RGGGLSPLRLVLAGVAVSALFSALTSLLLLLADPEQLRSIV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190 189 KWLVGNVWGRDWIHVLALLPWIFILTPYAWLKSKTLNALSLGDSVAAGLGVSVQKERLLLLATAVGLSCASVSMAGGIGF 268
Cdd:COG0609   157 FWLMGSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGF 236

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190 269 IGLVAPHIARKLVGTTYQHFLPLAGIIGMIILVLADTIGRSIFEPNSIPAGVVVAALGAPYFLYLLTKTK 338
Cdd:COG0609   237 VGLVVPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRRR 306
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 24-336 9.00e-81

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 248.21  E-value: 9.00e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190  24 IAVILISLNTGTLSIAPLKVIQTLFGYGDFESATVLYDYRMPRIIITMLAGIGLGVSGAILQGLSRNALADPGILGLHAG 103
Cdd:pfam01032   3 LLLILLSLFIGAVKISPSDVFSALLGGDDSLAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGISSG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190 104 ASFGLILFVTFFHSINENAsilIPLFTFGGGVLAAFLIILLASdRSKGLLPIRLILVGIAVSAGFSAISLFFSLKLNDET 183
Cdd:pfam01032  83 AALGAVLAILLGGSLSLFA---LPLAAFIGALLAALLVYFLSR-GRGGASPLRLILAGIAVSALLSALTSLLLLLLNPEA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190 184 YIFASKWLVGNVWGRDWIHVLALLPWIFILTPYAWLKSKTLNALSLGDSVAAGLGVSVQKERLLLLATAVGLSCASVSMA 263
Cdd:pfam01032 159 LQSILFWLMGSLSGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVV 238

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2211962190 264 GGIGFIGLVAPHIARKLVGTTYQHFLPLAGIIGMIILVLADTIGRSIFEPNSIPAGVVVAALGAPYFLYLLTK 336
Cdd:pfam01032 239 GPIGFVGLIVPHIARLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLLR 311
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
54-337 1.71e-68

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 226.26  E-value: 1.71e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190  54 ESATVLYDYRMPRIIITMLAGIGLGVSGAILQGLSRNALADPGILGLHAGASFGLILFVTFFHSineNASILIPLFTFGG 133
Cdd:PRK10577  388 QLLDALLPLRLPRLLAALLAGAMLAVAGTLLQRLTRNPLASPEVLGISSGAGLGVVLALFLVPG---AGFGWLLAAALLG 464

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190 134 GVLAAFLIILLAsdRSKGLLPIRLILVGIAVSAGFSAISLFFSLKLNDETYIFASkWLVGNVWGRDWIHVLALLPWIFIL 213
Cdd:PRK10577  465 ALAALALILLLA--RRGGFAPERLLLTGIALSALFTALIQLLLASGDPRAAQLLT-WLSGSTYGVTWAQALPLLIVAVLL 541

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190 214 TPYAWLKSKTLNALSLGDSVAAGLGVSVQKERLLLLATAVGLSCASVSMAGGIGFIGLVAPHIARKLVGTTYQHFLPLAG 293
Cdd:PRK10577  542 LALALLLRRWLDLLPLGDDTARALGLPVTRARLALLLLAALLTAAATATVGPLSFVGLMAPHLARMLGGRRARPQLVLAA 621

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 2211962190 294 IIGMIILVLADTIGRSIFEPNSIPAGVVVAALGAPYFLYLLTKT 337
Cdd:PRK10577  622 LLGALLMVLADWLGRTLLFPYQIPAGLLAALIGAPYFLWLLRRS 665
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 67-334 9.46e-51

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 169.27  E-value: 9.46e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190  67 IIITMLAGIGLGVSGAILQGLSRNALADPGILGLHAGASFGLILFVTFFHSineNASILIPLFTFGGGVLAAFLIILLAs 146
Cdd:cd06550     1 LLAALLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIG---LSNYALGAFAFAGALAIALLVLLLA- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190 147 dRSKGLLPIRLILVGIAVSAGFSAISLFFSLkLNDETYIFASKWLVGNVWGRDWIHVLALLPWIFILTPYAWLKSKTLNA 226
Cdd:cd06550    77 -SRGGLSPSKLILIGIVLSAFFSAGVILISL-LSDDSLQDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190 227 LSLGDSVAAGLGVSVQKERLLLLATAVGLSCASVSMAGGIGFIGLVAPHIARKLVGTTYQHFLPLAGIIGMIILVLADTI 306
Cdd:cd06550   155 LTFDEDLAKSLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLL 234

                         250       260
                  ....*....|....*....|....*...
gi 2211962190 307 GRSIFePNSIPAGVVVAALGAPYFLYLL 334
Cdd:cd06550   235 SRTLL-PSELPVGPVTALLGAPYFLYLL 261
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 30-338 2.29e-97

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 290.43  E-value: 2.29e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190  30 SLNTGTLSIAPLKVIQTLFGY-GDFESATVLYDYRMPRIIITMLAGIGLGVSGAILQGLSRNALADPGILGLHAGASFGL 108
Cdd:COG0609     1 SLSLGAVPISLSDVLRALLGPdGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190 109 ILFVTFFHSInenASILIPLFTFGGGVLAAFLIILLASdRSKGLLPIRLILVGIAVSAGFSAISLFFSLKLNDETYIFAS 188
Cdd:COG0609    81 VLAIVLGGGL---SALGLPLAAFLGALLAALLVYLLAR-RGGGLSPLRLVLAGVAVSALFSALTSLLLLLADPEQLRSIV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190 189 KWLVGNVWGRDWIHVLALLPWIFILTPYAWLKSKTLNALSLGDSVAAGLGVSVQKERLLLLATAVGLSCASVSMAGGIGF 268
Cdd:COG0609   157 FWLMGSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGF 236

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190 269 IGLVAPHIARKLVGTTYQHFLPLAGIIGMIILVLADTIGRSIFEPNSIPAGVVVAALGAPYFLYLLTKTK 338
Cdd:COG0609   237 VGLVVPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRRR 306
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 24-336 9.00e-81

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 248.21  E-value: 9.00e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190  24 IAVILISLNTGTLSIAPLKVIQTLFGYGDFESATVLYDYRMPRIIITMLAGIGLGVSGAILQGLSRNALADPGILGLHAG 103
Cdd:pfam01032   3 LLLILLSLFIGAVKISPSDVFSALLGGDDSLAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGISSG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190 104 ASFGLILFVTFFHSINENAsilIPLFTFGGGVLAAFLIILLASdRSKGLLPIRLILVGIAVSAGFSAISLFFSLKLNDET 183
Cdd:pfam01032  83 AALGAVLAILLGGSLSLFA---LPLAAFIGALLAALLVYFLSR-GRGGASPLRLILAGIAVSALLSALTSLLLLLLNPEA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190 184 YIFASKWLVGNVWGRDWIHVLALLPWIFILTPYAWLKSKTLNALSLGDSVAAGLGVSVQKERLLLLATAVGLSCASVSMA 263
Cdd:pfam01032 159 LQSILFWLMGSLSGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVV 238

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2211962190 264 GGIGFIGLVAPHIARKLVGTTYQHFLPLAGIIGMIILVLADTIGRSIFEPNSIPAGVVVAALGAPYFLYLLTK 336
Cdd:pfam01032 239 GPIGFVGLIVPHIARLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLLR 311
FepG COG4779
ABC-type enterobactin transport system, permease component [Inorganic ion transport and ...
 11-337 1.50e-79

ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 443810  Cd Length: 344  Bit Score: 246.19  E-value: 1.50e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190  11 RAITVTTIFGCVGIAVILISLNTGTLSIAPLKVIQTLFGYGDFESATVLYDYRMPRIIITMLAGIGLGVSGAILQGLSRN 90
Cdd:COG4779    21 RALLVTLVLLLLLLALAVLALTLGDYPLSPGDVLRALLGEGDPGASFVVLELRLPRALAALLVGAALGLSGAIFQSLTRN 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190  91 ALADPGILGLHAGASFGLILFVTFFHSinenASILIPLFTFGGGVLAAFLIILLAsdRSKGLLPIRLILVGIAVSAGFSA 170
Cdd:COG4779   101 PLASPDIIGITAGASAGAVAAIVVLGG----SGLAVALGALAGGLATALLVYLLA--WRGGVSGYRLILVGIGVSAMLTA 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190 171 ISLFFSLKLNDETYIFASKWLVGNVWGRDWIHVLALLPWIFILTPYAWLKSKTLNALSLGDSVAAGLGVSVQKERLLLLA 250
Cdd:COG4779   175 VNSYLLTRADLEDAQSAAVWLTGSLNGRTWEDVLPLAVALAVLLPLALALARRLRLLELGDDTAAALGVRVERTRLLLLL 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190 251 TAVGLSCASVSMAGGIGFIGLVAPHIARKLVGTTYQHFLPlAGIIGMIILVLADTIGRSIFEPNSIPAGVVVAALGAPYF 330
Cdd:COG4779   255 VAVALAAVATAAAGPIAFVALAAPQIARRLTRSPGPPLLP-SALVGALLLLAADLVAQHLLAPVQLPVGVVTGALGGPYL 333


                  ....*..
gi 2211962190 331 LYLLTKT 337
Cdd:COG4779   334 LWLLIRE 340
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
54-337 1.71e-68

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 226.26  E-value: 1.71e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190  54 ESATVLYDYRMPRIIITMLAGIGLGVSGAILQGLSRNALADPGILGLHAGASFGLILFVTFFHSineNASILIPLFTFGG 133
Cdd:PRK10577  388 QLLDALLPLRLPRLLAALLAGAMLAVAGTLLQRLTRNPLASPEVLGISSGAGLGVVLALFLVPG---AGFGWLLAAALLG 464

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190 134 GVLAAFLIILLAsdRSKGLLPIRLILVGIAVSAGFSAISLFFSLKLNDETYIFASkWLVGNVWGRDWIHVLALLPWIFIL 213
Cdd:PRK10577  465 ALAALALILLLA--RRGGFAPERLLLTGIALSALFTALIQLLLASGDPRAAQLLT-WLSGSTYGVTWAQALPLLIVAVLL 541

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190 214 TPYAWLKSKTLNALSLGDSVAAGLGVSVQKERLLLLATAVGLSCASVSMAGGIGFIGLVAPHIARKLVGTTYQHFLPLAG 293
Cdd:PRK10577  542 LALALLLRRWLDLLPLGDDTARALGLPVTRARLALLLLAALLTAAATATVGPLSFVGLMAPHLARMLGGRRARPQLVLAA 621

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 2211962190 294 IIGMIILVLADTIGRSIFEPNSIPAGVVVAALGAPYFLYLLTKT 337
Cdd:PRK10577  622 LLGALLMVLADWLGRTLLFPYQIPAGLLAALIGAPYFLWLLRRS 665
fecD PRK09777
Fe(3+) dicitrate ABC transporter permease subunit FecD;
11-338 4.10e-65

Fe(3+) dicitrate ABC transporter permease subunit FecD;


Pssm-ID: 182071  Cd Length: 318  Bit Score: 208.36  E-value: 4.10e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190  11 RAITVTTIFGCVGIAVILISLNTGTLSIaPLKVIQTLFGYGDfESATVLYDYRMPRIIITMLAGIGLGVSGAILQGLSRN 90
Cdd:PRK09777    1 MKIALVIFITLALAGCALLSLRMGVIPL-PWRALLTDWQAGD-EHYYVLMEYRLPRLLLALFVGAALAVSGVLVQGIVRN 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190  91 ALADPGILGLHAGASFGLILFVTFFHSInenASILIPLFTFGGGVLAAFLIILLASDRSkgllPIRLILVGIAVSAGFSA 170
Cdd:PRK09777   79 PLASPDILGVNHAASLASVGALLLFPSL---PVMWLPLLAFIGGMAGLILLKMLAGTHQ----PMKLALTGVALSALWAS 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190 171 ISLFFSLKlNDETYIFASKWLVGNVWGRDWIHVLALLPWIFILTPYAWLKSKTLNALSLGDSVAAGLGVSVQKERLLLLA 250
Cdd:PRK09777  152 LTDYLMLS-RPQDINNALLWLTGSLWGRDWSFVKVALPWLILLLPLSLSFCRDLDLLALGDARATTLGVSVPHTQFWALL 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190 251 TAVGLSCASVSMAGGIGFIGLVAPHIARKLVGTTYQHFLPLAGIIGMIILVLADTIGRSIFEPNSIPAGVVVAALGAPYF 330
Cdd:PRK09777  231 LAVALTATGVAACGPISFIGLVVPHLMRSLVGGRHRRLLPVSALTGALLLLLADLLARIIHPPLELPAGVLTAIIGAPWF 310


                  ....*...
gi 2211962190 331 LYLLTKTK 338
Cdd:PRK09777  311 FWLLVRMR 318
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
11-338 3.37e-55

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 190.82  E-value: 3.37e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190  11 RAITVTTIFGCVGIAVILISLNTGTLSIAPLKVIQTLFGYGDFESAT-VLYDYRMPRIIITMLAGIGLGVSGAILQGLSR 89
Cdd:PRK10577    9 RARLPALLLALLLLLALALTLTQLSAALPLSQWLQALWGPDADDLEQlLLHYSRLPRLAIALLVGAALGLAGALLQQVLR 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190  90 NALADPGILGLHAGASFGLILFVTFFHSINENASiliPLFTFGGGVLAAFLIILLASdrSKGLLPIRLILVGIAVSAGFS 169
Cdd:PRK10577   89 NPLASPTTLGVAAGAQLALVLATLFAPALLALAS---QLAAFAGGLLAAALVFALAG--GKRLSPLRLVLAGMVVSLYLG 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190 170 AISLFFSLkLNDETYIFASKWLVGNVWGRDWIHVLALLPWIFILTPYAWLKSKTLNALSLGDSVAAGLGVSVQKERLLLL 249
Cdd:PRK10577  164 ALTTLLLL-FNEQYLQGLFLWGAGSLAQNDWSGVQRLLPRLLVGLLLLLLLARPLTLLGLGDDVARSLGLAVSLTRLAAL 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190 250 ATAVGLSCASVSMAGGIGFIGLVAPHIARKLVGTTYQHFLPLAGIIGMIILVLADTIGRSI--FEPNSIPAGVVVAALGA 327
Cdd:PRK10577  243 ALAVLLSAAVVSAVGPIGFIGLAAPNLARLLGARRLRARLPLSPLIGALLLLLTDQLVRLLagVGGELLPTGAVTALIGA 322

                         330
                  ....*....|.
gi 2211962190 328 PYFLYLLTKTK 338
Cdd:PRK10577  323 PLLLWLLPRLR 333
PRK10440 PRK10440
iron-enterobactin ABC transporter permease;
17-334 6.50e-52

iron-enterobactin ABC transporter permease;


Pssm-ID: 182463  Cd Length: 330  Bit Score: 174.51  E-value: 6.50e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190  17 TIFGCVGIAviLISLNTGTLSIAPLKVIQTLFGYGDFESATVLYDYRMPRIIITMLAGIGLGVSGAILQGLSRNALADPG 96
Cdd:PRK10440   15 LLAACVAAG--LWGLRSGAVTLETSQVFAALMGDAPRSMTMVVTEWRLPRVLMALLIGAALGVSGAIFQSLMRNPLGSPD 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190  97 ILGLHAGASFGLILFVTFFhsinENASILIPLFTFGGGVLAAFLIILLAsdRSKGLLPIRLILVGIAVSAGFSAISLFFS 176
Cdd:PRK10440   93 VMGFNTGAWSGVLVAMVLF----GQDLTAIALAAMAGGIVTSLLVWLLA--WRNGIDTFRLIIIGIGVRAMLVAFNTWLL 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190 177 LKLNDETYIFASKWLVGNVWGRDWIHVLALLPWIFILTPYAWLKSKTLNALSLGDSVAAGLGVSVQKERLLLLATAVGLS 256
Cdd:PRK10440  167 LKASLETALTAGLWNAGSLNGLTWAKTSPSAPIIILMLIAAALLVRRMRLLEMGDDTACALGVSVERSRLLLMLVAVVLT 246

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2211962190 257 CASVSMAGGIGFIGLVAPHIARKLVGTTyQHFLPLAGIIGMIILVLADTIGRSIFEPNSIPAGVVVAALGAPYFLYLL 334
Cdd:PRK10440  247 AAATALAGPISFIALVAPHIARRLSGTA-RWGLTQAALCGALLLLAADLCAQQLFMPYQLPVGVVTVSLGGIYLIVLL 323
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 67-334 9.46e-51

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 169.27  E-value: 9.46e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190  67 IIITMLAGIGLGVSGAILQGLSRNALADPGILGLHAGASFGLILFVTFFHSineNASILIPLFTFGGGVLAAFLIILLAs 146
Cdd:cd06550     1 LLAALLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIG---LSNYALGAFAFAGALAIALLVLLLA- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190 147 dRSKGLLPIRLILVGIAVSAGFSAISLFFSLkLNDETYIFASKWLVGNVWGRDWIHVLALLPWIFILTPYAWLKSKTLNA 226
Cdd:cd06550    77 -SRGGLSPSKLILIGIVLSAFFSAGVILISL-LSDDSLQDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190 227 LSLGDSVAAGLGVSVQKERLLLLATAVGLSCASVSMAGGIGFIGLVAPHIARKLVGTTYQHFLPLAGIIGMIILVLADTI 306
Cdd:cd06550   155 LTFDEDLAKSLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLL 234

                         250       260
                  ....*....|....*....|....*...
gi 2211962190 307 GRSIFePNSIPAGVVVAALGAPYFLYLL 334
Cdd:cd06550   235 SRTLL-PSELPVGPVTALLGAPYFLYLL 261
BtuC COG4139
ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and ...
 4-338 2.98e-48

ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and metabolism];


Pssm-ID: 443314  Cd Length: 327  Bit Score: 165.03  E-value: 2.98e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190   4 LLNTDKKRAITVTTIFGCVGIAVILISLNTGTLSIAPLKVIQTLFGYgdfesatVLYDYRMPRIIITMLAGIGLGVSGAI 83
Cdd:COG4139     3 LPQRQRRRDRRWLLLLLLLLLLLFVLSLCAGEVWIPPTQWLSEAWQL-------FVWQLRLPRTLAAVLVGASLAVSGAV 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190  84 LQGLSRNALADPGILGLHAGASFGLILFVTFFHSINENASILIPLFTfggGVLAAFLIILLASDRSKGllPIRLILVGIA 163
Cdd:COG4139    76 MQALFENPLAEPGLLGISNGAGVGLVLVVLLGGGLLPPWLLSLAAIA---GALLVTLLLLAFARRRLS--NARLLLIGVA 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190 164 VSAGFSAI---SLFFSLKLNDETYIFaskWLVGNVWGRDWIH---VLALLPWIFILTpyawLKSKTLNALSLGDSVAAGL 237
Cdd:COG4139   151 LGIICSAImtwAVYFSSSLDLRQLMY---WMMGSFGGVDWRQlwlLLALLPVLLWLC----LQGKPLNLLLLGENQARQL 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190 238 GVSVQKER-LLLLATAVgLSCASVSMAGGIGFIGLVAPHIARKLVGTTYQHFLPLAGIIGMIILVLADTIGRSIFEPNSI 316
Cdd:COG4139   224 GLSVHRWRnLLVLATGL-LVGVSVALAGPIGFVGLVVPHLLRLLGTTDHRFLLPACALAGAALLLLADIIARLALSSAEL 302

                         330       340
                  ....*....|....*....|..
gi 2211962190 317 PAGVVVAALGAPYFLYLLTKTK 338
Cdd:COG4139   303 PIGVVTATLGAPVFIWLLLRRR 324
PRK03784 PRK03784
vtamin B12-transporter permease; Provisional
 1-338 1.18e-47

vtamin B12-transporter permease; Provisional


Pssm-ID: 235159  Cd Length: 331  Bit Score: 163.59  E-value: 1.18e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190   1 MKDLLNTDKKRAITVTTIFGCVGIAVILISLNTGTLSIAPLKVIQTLfgygdfeSATVLYDYRMPRIIITMLAGIGLGVS 80
Cdd:PRK03784    3 MLTLARQQQRRNRRWLLGLSVLLLLALLLSLCAGEQWISPGDWLSPR-------GELFVWQLRLPRTLAVLLVGAALAVS 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190  81 GAILQGLSRNALADPGILGLHAGASFGLILFVTFFHSINenASILIPLFTFGGGVLAAFLIILLAsdRSKGLLPIRLILV 160
Cdd:PRK03784   76 GAVMQALFENPLAEPGLLGVSNGAGVALVAAVLLGQGLL--PPWALSLCAIAGALLITLILLRFA--RRHRLSTSRLLLA 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190 161 GIAVSAGFSAI---SLFFSLKLNDETYIFaskWLVGNVWGRDWIH---VLALLPWIFILTpyawLKSKTLNALSLGDSVA 234
Cdd:PRK03784  152 GVALGIICSALmtwAVYFSTSLDLRQLMY---WMMGGFGGVDWRQswlMLALLPVLIWLC----CQGRPLNMLALGEISA 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190 235 AGLGVSVQKERLLLLATAVGLSCASVSMAGGIGFIGLVAPHIARKLVGTTYQHFLPLAGIIGMIILVLADTIGRSIFEPN 314
Cdd:PRK03784  225 RQLGLPLWFWRNLLVLATGWLVGVSVALAGAIGFIGLVIPHILRLCGLTDHRVLLPGCALAGASLLLLADIVARLALASA 304

                         330       340
                  ....*....|....*....|....
gi 2211962190 315 SIPAGVVVAALGAPYFLYLLTKTK 338
Cdd:PRK03784  305 ELPIGVVTATLGAPVFIWLLLRSH 328
btuC PRK09535
cobalamin ABC transporter permease BtuC;
22-336 1.33e-45

cobalamin ABC transporter permease BtuC;


Pssm-ID: 236553  Cd Length: 366  Bit Score: 159.15  E-value: 1.33e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190  22 VGIAVILISLNTGTLSIAPLkviqtlFGYGDFESA-TVLYDYRMPRIIITMLAGIGLGVSGAILQGLSRNALADPGILGL 100
Cdd:PRK09535   59 VPVLSVGLSLPAPDLEYASP------FSFAVPETAqTIVLQIRLPRILLAATVGFALAAAGTVMQGFFRNPMADPSIIGV 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190 101 HAGASFGLILFVTFFHSInenaSILIPLFTFGGGVLAAFLIILLASDrsKGLLPI-RLILVGIAVSAGFSAISLFFSLKL 179
Cdd:PRK09535  133 SSGAAVGAVAAIVLPLAV----PFGLQAAAFAGALVAAFGVYAIATE--NGRTPVaTLLLAGVAVQTFLGAVISYLLLHS 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190 180 NDETYIfASKWLVGNVWGRDWIHVLALLPWIFILTPYAWLKSKTLNALSLGDSVAAGLGVSVQKERLLLLATAVGLSCAS 259
Cdd:PRK09535  207 GESLRR-AVYWLMGHLHGSTWSDVEVALPVVVVGFVVLLAYARDLNVLLLGEEDAHTLGIEVERTKRLLLALASVVTAAA 285

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2211962190 260 VSMAGGIGFIGLVAPHIARKLVGTTYQHFLPLAGIIGMIILVLADTIGRSifEPNSIPAGVVVAALGAPYFLYLLTK 336
Cdd:PRK09535  286 VAVAGVIGFVGLIVPHVMRLLVGPDHRILLPTSALAGASFLVATDTVARS--GPAEVPVGIVTAALGAPFFLYLLRT 360
fecC PRK11228
iron-dicitrate ABC transporter permease FecC;
36-333 2.13e-45

iron-dicitrate ABC transporter permease FecC;


Pssm-ID: 183042  Cd Length: 323  Bit Score: 157.16  E-value: 2.13e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190  36 LSIAPLKVIQTLF-GYGDFESATVLYDYRMPRIIITMLAGIGLGVSGAILQGLSRNALADPGILGLHAGASFGLILFVTF 114
Cdd:PRK11228   23 IPISAADALNALLpGHTPTLPEALVQNLRLPRSLVAVLIGASLALAGALLQTLTHNPLASPSLLGINSGAALAMALTSAL 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190 115 FHSINENASIliPLFTFGGGVLAAFLIILLASDRSKGLLPIRLILVGIAVSAGFSAISLFFSLKLNDETYIFASkWLVGN 194
Cdd:PRK11228  103 SPTPFAGYSL--AFIAACGGGLSWLLVMTAGGGWRHTHDRNRLILAGIALSALCMALTRITLLLAEDHAYGIFY-WLAGG 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190 195 VWGRDWIHVLALLPWIFILTPYAWLKSKTLNALSLGDSVAAGLGVSVQKERLLLLATAVGLSCASVSMAGGIGFIGLVAP 274
Cdd:PRK11228  180 VSHARWQEVWQLLPFVVTAVPVVLLLANQLNLLNLSDSSAHTLGVNLTRLRLVVNMLVLLLVGACVSVAGPVAFIGLLVP 259

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2211962190 275 HIARKLVGTTYQHFLPLAGIIGMIILVLADTIGRSIFEPNSIPAGVVVAALGAPYFLYL 333
Cdd:PRK11228  260 HLARFWIGYDQRNVLPMSMLLGATLMLLADLLARALAFPGELPAGAVLALIGAPCFVWL 318
PRK10441 PRK10441
Fe(3+)-siderophore ABC transporter permease;
11-333 4.98e-43

Fe(3+)-siderophore ABC transporter permease;


Pssm-ID: 182464  Cd Length: 335  Bit Score: 151.40  E-value: 4.98e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190  11 RAITVTTIFGCVGIAVILiSLNTGTLSIAPLKVIQTLFGYGDFESATVLYDYRMPRIIITMLAGIGLGVSGAILQGLSRN 90
Cdd:PRK10441    9 RAIAVPGLLLLLIIATAL-SLLIGAKSLPASVVLEALSGTCQSADCTIVLDARLPRTLAGLLAGGALGLAGALMQTLTRN 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190  91 ALADPGILGLHAGASFGLILFVTFF--HSINEnasilIPLFTFGGGVLAAFLIILLASDRSKGLLPIRLILVGIAVSAGF 168
Cdd:PRK10441   88 PLADPGLLGVNAGASFAIVLGAALFgySSAQE-----QLAMAFAGALVASLIVAFTGSQGGGQLSPVRLTLAGVALAAVL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190 169 SAISLFFSLkLNDETYIFASKWLVGNVWGRDWIHVLALLPWIFILTPYAWLKSKTLNALSLGDSVAAGLGVSVQKERLLL 248
Cdd:PRK10441  163 EGLTSGIAL-LNPDVYDQLRFWQAGSLDIRNLHTLKVVLIPVLIAGATALLLSRALNSLSLGSDTATALGSRVARTQLIG 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211962190 249 LATAVGLSCASVSMAGGIGFIGLVAPHIARKLVGTTYQHFLPLAGIIGMIILVLADTIGRSIFePNSIPAGVVVAALGAP 328
Cdd:PRK10441  242 LLAITVLCGSATAVVGPIAFIGLMMPHMARWLVGADHRWSLPVTLLATPALLLFADIIGRLLV-PGELRVSVVSAFIGAP 320


                  ....*
gi 2211962190 329 YFLYL 333
Cdd:PRK10441  321 VLIFL 325
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH