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Conserved domains on  [gi|2213300658|ref|WP_242627758|]
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MULTISPECIES: nucleotidyl transferase AbiEii/AbiGii toxin family protein [Klebsiella]

Protein Classification

nucleotidyl transferase AbiEii/AbiGii toxin family protein( domain architecture ID 10556042)

nucleotidyl transferase family protein similar to abortive infection proteins AbiEii/AbiGii

PubMed:  19833706

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
AbiEii pfam08843
Nucleotidyl transferase AbiEii toxin, Type IV TA system; This family was recently identified ...
3-57 1.28e-06

Nucleotidyl transferase AbiEii toxin, Type IV TA system; This family was recently identified as belonging to the nucleotidyltransferase superfamily. AbiEii is the cognate toxin of the type IV toxin-antitoxin 'innate immunity' bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection. The Abi system is activated upon infection with phage to abort the cell thus preventing the spread of phage through viral replication. There are some 20 or more Abis, and they are predominantly plasmid-encoded lactococcal systems. TA, toxin-antitoxin, systems on plasmids function by killing cells that lose the plasmid upon division. AbiE phage resistance systems function as novel Type IV TAs and are widespread in bacteria and archaea. The cognate antitoxin is pfam13338.


:

Pssm-ID: 430254  Cd Length: 239  Bit Score: 42.96  E-value: 1.28e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2213300658   3 FGGRNRGKPMDTITVSSYLsgikglgELELPSATVQVYNPGYILWEKITALHQFC 57
Cdd:pfam08843 107 IGFRDAVPPPERRPLPPLL-------EELGPAFEVPVYSLEELLAEKLLALLDRG 154
 
Name Accession Description Interval E-value
AbiEii pfam08843
Nucleotidyl transferase AbiEii toxin, Type IV TA system; This family was recently identified ...
3-57 1.28e-06

Nucleotidyl transferase AbiEii toxin, Type IV TA system; This family was recently identified as belonging to the nucleotidyltransferase superfamily. AbiEii is the cognate toxin of the type IV toxin-antitoxin 'innate immunity' bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection. The Abi system is activated upon infection with phage to abort the cell thus preventing the spread of phage through viral replication. There are some 20 or more Abis, and they are predominantly plasmid-encoded lactococcal systems. TA, toxin-antitoxin, systems on plasmids function by killing cells that lose the plasmid upon division. AbiE phage resistance systems function as novel Type IV TAs and are widespread in bacteria and archaea. The cognate antitoxin is pfam13338.


Pssm-ID: 430254  Cd Length: 239  Bit Score: 42.96  E-value: 1.28e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2213300658   3 FGGRNRGKPMDTITVSSYLsgikglgELELPSATVQVYNPGYILWEKITALHQFC 57
Cdd:pfam08843 107 IGFRDAVPPPERRPLPPLL-------EELGPAFEVPVYSLEELLAEKLLALLDRG 154
 
Name Accession Description Interval E-value
AbiEii pfam08843
Nucleotidyl transferase AbiEii toxin, Type IV TA system; This family was recently identified ...
3-57 1.28e-06

Nucleotidyl transferase AbiEii toxin, Type IV TA system; This family was recently identified as belonging to the nucleotidyltransferase superfamily. AbiEii is the cognate toxin of the type IV toxin-antitoxin 'innate immunity' bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection. The Abi system is activated upon infection with phage to abort the cell thus preventing the spread of phage through viral replication. There are some 20 or more Abis, and they are predominantly plasmid-encoded lactococcal systems. TA, toxin-antitoxin, systems on plasmids function by killing cells that lose the plasmid upon division. AbiE phage resistance systems function as novel Type IV TAs and are widespread in bacteria and archaea. The cognate antitoxin is pfam13338.


Pssm-ID: 430254  Cd Length: 239  Bit Score: 42.96  E-value: 1.28e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2213300658   3 FGGRNRGKPMDTITVSSYLsgikglgELELPSATVQVYNPGYILWEKITALHQFC 57
Cdd:pfam08843 107 IGFRDAVPPPERRPLPPLL-------EELGPAFEVPVYSLEELLAEKLLALLDRG 154
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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