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Conserved domains on  [gi|2214426814|ref|WP_242830769|]
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sensor histidine kinase [Hungatella hathewayi]

Protein Classification

sensor histidine kinase( domain architecture ID 11459466)

sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to a signal; may contain an N-terminal HAMP signaling domain

CATH:  3.30.565.10
EC:  2.7.13.3
Gene Ontology:  GO:0000155|GO:0004673|GO:0007165|GO:0005524|GO:0000156
PubMed:  10339418|11406410|10966457|8029829|18076326|11489844
SCOP:  4001957

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
122-571 2.52e-74

Sensor histidine kinase YesM [Signal transduction mechanisms];


:

Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 243.77  E-value: 2.52e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214426814 122 NIIYTSFSSESMNLHRIAFNQIVGENALKYDGDIYRTVYYFSGDTSEYVFTKPLYDVDSDSEKPVGYAAIYLNGRDWGKL 201
Cdd:COG2972     1 LSKSLSLLSIVLLLLILLLLVLLILLLSLLLIILLLLLLLILLLLLLILLLLLLLLLLLLLLLLLLLLLLLLLLLLLALL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214426814 202 LTDYQYDSIITTLNGDIIHCSKEGFLKERNGNKYRPADNTGMTSIHGVRYLISSRQLPGPSVILYSFIYYPKNVPYMGIG 281
Cdd:COG2972    81 LILLLLLLLLLLLILLLSLLLLLALILLLALLLLLSILLLILGLLLIILLLLSLLGWTLVSLIPKSELFRGLFSLRRLIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214426814 282 ILTIIFLgVLWFLMSLRLTRGMAernaRSVNLLADELRIIRHGDsGHTVTISTGDEFEEIANHINRMVKSINELNTRNTD 361
Cdd:COG2972   161 LIILLLL-LLALLLSYLLSRSIT----RPIKRLKKAMKKVEKGD-LVRLEVSGNDEIGILARSFNEMVERIKELIEEVYE 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214426814 362 LIRLNSMIEMSNLQTQINPHFIYNTLDNIKYLIFSE-PDKAAYLIERFTHILRYSINNTKHDVPLYEDMEYIQDYLYIQN 440
Cdd:COG2972   235 LELEKKEAELKALQAQINPHFLFNTLNSIRWLAELEdPEEAEEMLEALSKLLRYSLSKGDELVTLEEELELIKSYLEIQK 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214426814 441 TRFGSRFVCSIDIQEECNRYNVPKLLLQPLIENSIKYGFKKRMDIA-VAIRGWCEEDSMVLTVEDNGPGVPRTTLETLRT 519
Cdd:COG2972   315 LRFGDRLEVEIEIDEELLDLLIPKLILQPLVENAIEHGIEPKEGGGtIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLE 394

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2214426814 520 MLASEEiKTEHNGLQNLARRIVLEYGEGSGMSIDSMEGEYFKVTVRLKHREG 571
Cdd:COG2972   395 ELSSKG-EGRGIGLRNVRERLKLYYGEEYGLEIESEPGEGTTVTIRIPLEEE 445
 
Name Accession Description Interval E-value
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
122-571 2.52e-74

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 243.77  E-value: 2.52e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214426814 122 NIIYTSFSSESMNLHRIAFNQIVGENALKYDGDIYRTVYYFSGDTSEYVFTKPLYDVDSDSEKPVGYAAIYLNGRDWGKL 201
Cdd:COG2972     1 LSKSLSLLSIVLLLLILLLLVLLILLLSLLLIILLLLLLLILLLLLLILLLLLLLLLLLLLLLLLLLLLLLLLLLLLALL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214426814 202 LTDYQYDSIITTLNGDIIHCSKEGFLKERNGNKYRPADNTGMTSIHGVRYLISSRQLPGPSVILYSFIYYPKNVPYMGIG 281
Cdd:COG2972    81 LILLLLLLLLLLLILLLSLLLLLALILLLALLLLLSILLLILGLLLIILLLLSLLGWTLVSLIPKSELFRGLFSLRRLIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214426814 282 ILTIIFLgVLWFLMSLRLTRGMAernaRSVNLLADELRIIRHGDsGHTVTISTGDEFEEIANHINRMVKSINELNTRNTD 361
Cdd:COG2972   161 LIILLLL-LLALLLSYLLSRSIT----RPIKRLKKAMKKVEKGD-LVRLEVSGNDEIGILARSFNEMVERIKELIEEVYE 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214426814 362 LIRLNSMIEMSNLQTQINPHFIYNTLDNIKYLIFSE-PDKAAYLIERFTHILRYSINNTKHDVPLYEDMEYIQDYLYIQN 440
Cdd:COG2972   235 LELEKKEAELKALQAQINPHFLFNTLNSIRWLAELEdPEEAEEMLEALSKLLRYSLSKGDELVTLEEELELIKSYLEIQK 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214426814 441 TRFGSRFVCSIDIQEECNRYNVPKLLLQPLIENSIKYGFKKRMDIA-VAIRGWCEEDSMVLTVEDNGPGVPRTTLETLRT 519
Cdd:COG2972   315 LRFGDRLEVEIEIDEELLDLLIPKLILQPLVENAIEHGIEPKEGGGtIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLE 394

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2214426814 520 MLASEEiKTEHNGLQNLARRIVLEYGEGSGMSIDSMEGEYFKVTVRLKHREG 571
Cdd:COG2972   395 ELSSKG-EGRGIGLRNVRERLKLYYGEEYGLEIESEPGEGTTVTIRIPLEEE 445
His_kinase pfam06580
Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. ...
 370-447 1.36e-28

Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. Two-component signal transduction systems such as those mediated by histidine kinase are integral parts of bacterial cellular regulatory processes, and are used to regulate the expression of genes involved in virulence. Members of this family often contain pfam02518 and/or pfam00672.


Pssm-ID: 461952 [Multi-domain]  Cd Length: 79  Bit Score: 108.68  E-value: 1.36e-28
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2214426814 370 EMSNLQTQINPHFIYNTLDNIKYLIFSEPDKAAYLIERFTHILRYSINNTKHDVPLYEDMEYIQDYLYIQNTRFGSRF 447
Cdd:pfam06580   2 ELKALQAQINPHFLFNTLNSISSLAIEDPEEAAEMILKLSDLLRYSLYEGEELVTLEEELEFLENYLEIQKIRFGDRL 79
HATPase_YehU-like cd16956
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 462-566 2.10e-16

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YehU; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Escherichia coli YehU, a HK of the two-component system (TCS) YehU-YehT which is involved in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase); some have a GAF sensor domain while some have a cupin domain.


Pssm-ID: 340432 [Multi-domain]  Cd Length: 101  Bit Score: 74.78  E-value: 2.10e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214426814 462 VPKLLLQPLIENSIKYGFKKRMDIA-VAIRGWCEEDSMVLTVEDNGPGV-PrttlETLRTMLASEeikTEHNGLQNLARR 539
Cdd:cd16956     1 LPFLTLQPIVENAVKHGLSGLLDGGrVEITARLDGQHLLLEVEDNGGGMdP----DTLARILIRS---SNGLGLNLVDKR 73

                          90       100
                  ....*....|....*....|....*..
gi 2214426814 540 IVLEYGEGSGMSIDSMEGEYFKVTVRL 566
Cdd:cd16956    74 LRQAFGNDYGLDIECAPGEGTRITIRL 100
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 466-567 5.33e-08

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 51.11  E-value: 5.33e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214426814  466 LLQPLIENSIKYGFKkrmDIAVAIRGWCEEDSMVLTVEDNGPGVPRTTLETL-----RTMLASEEIKTEHNGLQnLARRI 540
Cdd:smart00387   9 VLSNLLDNAIKYTPE---GGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIfepffRTDKRSRKIGGTGLGLS-IVKKL 84

                           90       100
                   ....*....|....*....|....*..
gi 2214426814  541 VLEYGeGSgMSIDSMEGEYFKVTVRLK 567
Cdd:smart00387  85 VELHG-GE-ISVESEPGGGTTFTITLP 109
PRK10490 PRK10490
sensor protein KdpD; Provisional
 467-510 2.20e-03

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 41.17  E-value: 2.20e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2214426814 467 LQPLIENSIKYGFKkrmDIAVAIRGWCEEDSMVLTVEDNGPGVP 510
Cdd:PRK10490  783 LINLLENAVKYAGA---QAEIGIDAHVEGERLQLDVWDNGPGIP 823
 
Name Accession Description Interval E-value
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
122-571 2.52e-74

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 243.77  E-value: 2.52e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214426814 122 NIIYTSFSSESMNLHRIAFNQIVGENALKYDGDIYRTVYYFSGDTSEYVFTKPLYDVDSDSEKPVGYAAIYLNGRDWGKL 201
Cdd:COG2972     1 LSKSLSLLSIVLLLLILLLLVLLILLLSLLLIILLLLLLLILLLLLLILLLLLLLLLLLLLLLLLLLLLLLLLLLLLALL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214426814 202 LTDYQYDSIITTLNGDIIHCSKEGFLKERNGNKYRPADNTGMTSIHGVRYLISSRQLPGPSVILYSFIYYPKNVPYMGIG 281
Cdd:COG2972    81 LILLLLLLLLLLLILLLSLLLLLALILLLALLLLLSILLLILGLLLIILLLLSLLGWTLVSLIPKSELFRGLFSLRRLIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214426814 282 ILTIIFLgVLWFLMSLRLTRGMAernaRSVNLLADELRIIRHGDsGHTVTISTGDEFEEIANHINRMVKSINELNTRNTD 361
Cdd:COG2972   161 LIILLLL-LLALLLSYLLSRSIT----RPIKRLKKAMKKVEKGD-LVRLEVSGNDEIGILARSFNEMVERIKELIEEVYE 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214426814 362 LIRLNSMIEMSNLQTQINPHFIYNTLDNIKYLIFSE-PDKAAYLIERFTHILRYSINNTKHDVPLYEDMEYIQDYLYIQN 440
Cdd:COG2972   235 LELEKKEAELKALQAQINPHFLFNTLNSIRWLAELEdPEEAEEMLEALSKLLRYSLSKGDELVTLEEELELIKSYLEIQK 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214426814 441 TRFGSRFVCSIDIQEECNRYNVPKLLLQPLIENSIKYGFKKRMDIA-VAIRGWCEEDSMVLTVEDNGPGVPRTTLETLRT 519
Cdd:COG2972   315 LRFGDRLEVEIEIDEELLDLLIPKLILQPLVENAIEHGIEPKEGGGtIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLE 394

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2214426814 520 MLASEEiKTEHNGLQNLARRIVLEYGEGSGMSIDSMEGEYFKVTVRLKHREG 571
Cdd:COG2972   395 ELSSKG-EGRGIGLRNVRERLKLYYGEEYGLEIESEPGEGTTVTIRIPLEEE 445
LytS COG3275
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
264-567 3.48e-56

Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];


Pssm-ID: 442506 [Multi-domain]  Cd Length: 352  Bit Score: 192.78  E-value: 3.48e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214426814 264 ILYSFIYYPKNVPYMGIGILTIIFLGVLWFLMSLRLTRGMAERNARSVNLLADELRIIRHGDSGHTVTISTGDEFEEIAN 343
Cdd:COG3275    54 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLIL 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214426814 344 HINRMVKSINELNTRNTDLIRLNSMIEMSNLQTQINPHFIYNTLDNIKYLIFSEPDKAAYLIERFTHILRYSINNTKHD- 422
Cdd:COG3275   134 ILLALLLSLQEEELELEELEKELLEAELKALKAQINPHFLFNTLNSIYSLIREDPEKARELLLKLSDLLRYSLYESDKEl 213

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214426814 423 VPLYEDMEYIQDYLYIQNTRFGSRFVCSIDIQEECNRYNVPKLLLQPLIENSIKYGFKKRMDIA-VAIRGWCEEDSMVLT 501
Cdd:COG3275   214 VPLEEELEFLENYLELEKLRFGDRLQVEIDIDEELLDLLIPPLLLQPLVENAIKHGISSKEGGGtISISIEVEGDRLVIE 293

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2214426814 502 VEDNGPGVPrttletlrtmlASEEIKTEHNGLQNLARRIVLEYGEGSGMSIDSMEGEYFKVTVRLK 567
Cdd:COG3275   294 VENNGVGIQ-----------PKKKKKGSGIGLKNVRERLELLYGDKYSLEIESTDGGGTKVTLKIP 348
His_kinase pfam06580
Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. ...
 370-447 1.36e-28

Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. Two-component signal transduction systems such as those mediated by histidine kinase are integral parts of bacterial cellular regulatory processes, and are used to regulate the expression of genes involved in virulence. Members of this family often contain pfam02518 and/or pfam00672.


Pssm-ID: 461952 [Multi-domain]  Cd Length: 79  Bit Score: 108.68  E-value: 1.36e-28
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2214426814 370 EMSNLQTQINPHFIYNTLDNIKYLIFSEPDKAAYLIERFTHILRYSINNTKHDVPLYEDMEYIQDYLYIQNTRFGSRF 447
Cdd:pfam06580   2 ELKALQAQINPHFLFNTLNSISSLAIEDPEEAAEMILKLSDLLRYSLYEGEELVTLEEELEFLENYLEIQKIRFGDRL 79
HATPase_YehU-like cd16956
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 462-566 2.10e-16

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YehU; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Escherichia coli YehU, a HK of the two-component system (TCS) YehU-YehT which is involved in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase); some have a GAF sensor domain while some have a cupin domain.


Pssm-ID: 340432 [Multi-domain]  Cd Length: 101  Bit Score: 74.78  E-value: 2.10e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214426814 462 VPKLLLQPLIENSIKYGFKKRMDIA-VAIRGWCEEDSMVLTVEDNGPGV-PrttlETLRTMLASEeikTEHNGLQNLARR 539
Cdd:cd16956     1 LPFLTLQPIVENAVKHGLSGLLDGGrVEITARLDGQHLLLEVEDNGGGMdP----DTLARILIRS---SNGLGLNLVDKR 73

                          90       100
                  ....*....|....*....|....*..
gi 2214426814 540 IVLEYGEGSGMSIDSMEGEYFKVTVRL 566
Cdd:cd16956    74 LRQAFGNDYGLDIECAPGEGTRITIRL 100
HATPase_YpdA-YehU-LytS-like cd16924
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 462-566 2.25e-16

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340401 [Multi-domain]  Cd Length: 103  Bit Score: 74.79  E-value: 2.25e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214426814 462 VPKLLLQPLIENSIKYGFKKRMDI-AVAIRGWCEEDSMVLTVEDNGPGVPRTTLETlrtmLASEEIKTEHNGLQNLARRI 540
Cdd:cd16924     1 IPPFTLQPLVENAIQHGLSPLTDKgVVTISALKEDNHVMIEVEDNGRGIDPKVLNI----LGKKPKEGNGIGLYNVHQRL 76

                          90       100
                  ....*....|....*....|....*.
gi 2214426814 541 VLEYGEGSGMSIDSMEGEYFKVTVRL 566
Cdd:cd16924    77 ILLFGEDYGIHIASEPDKGTRITFTI 102
HATPase_YpdA-like cd16955
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 462-554 7.48e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli YpdA, a HK of the two-component system (TCS) YpdA-YpdB which is involved in a nutrient sensing regulatory network with YehU-YehT. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and some have a GAF sensor domain; some contain a DUF3816 domain; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340431 [Multi-domain]  Cd Length: 102  Bit Score: 62.09  E-value: 7.48e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214426814 462 VPKLLLQPLIENSIKYGFKKR-----MDIAVAIrgwCEEDSMVLTVEDNGPGVPRTTLETLRTmlasEEIKTEHNGLQNL 536
Cdd:cd16955     1 IPKLMIQPLVENAIVHGIQEKkgkgvVKISVKK---QLKNRLHIAVEDNGIGISPKVIERVEQ----DEMPGNKIGLLNV 73

                          90
                  ....*....|....*...
gi 2214426814 537 ARRIVLEYGEgsGMSIDS 554
Cdd:cd16955    74 HQRLKLGYGE--GLHIRS 89
HATPase_LytS-like cd16957
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 462-566 4.27e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.


Pssm-ID: 340433 [Multi-domain]  Cd Length: 106  Bit Score: 59.75  E-value: 4.27e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214426814 462 VPKLLLQPLIENSIKYGFKKRMDI-AVAIRGWCEEDSMVLTVEDNGPGVPRTTLETLRTMLASEEiKTEHNGLQNLARRI 540
Cdd:cd16957     1 VPPFALQVLVENAIRHAFPKRKENnEVRVVVKKDQHKVHVSVSDNGQGIPEERLDLLGKTTVTSE-KGTGTALENLNRRL 79

                          90       100
                  ....*....|....*....|....*.
gi 2214426814 541 VLEYGEGSGMSIDSMEGEYFKVTVRL 566
Cdd:cd16957    80 IGLFGSEACLHIESEVHGGTEVWFVI 105
HAMP COG2770
HAMP domain [Signal transduction mechanisms];
278-413 1.97e-08

HAMP domain [Signal transduction mechanisms];


Pssm-ID: 442051 [Multi-domain]  Cd Length: 631  Bit Score: 57.05  E-value: 1.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214426814 278 MGIGILTIIFLGVLWFLMSLRLTRgmaernarSVNLLADELRIIRHGDSGHTVTISTGDEFEEIANHINRMVKSINELNT 357
Cdd:COG2770   215 LLLALLALLLALLLALLLARRITR--------PLRRLAEAARRIAAGDLDVRIPVSRKDEIGELARAFNRMADSLRESIE 286

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2214426814 358 RNTDLIRLNSMIEMSNLQTQINPHFIYNTLDNIKYLIFSEPDKAAYLIERFTHILR 413
Cdd:COG2770   287 EAEEEEELAEAELARLLEALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLL 342
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 466-567 5.33e-08

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 51.11  E-value: 5.33e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214426814  466 LLQPLIENSIKYGFKkrmDIAVAIRGWCEEDSMVLTVEDNGPGVPRTTLETL-----RTMLASEEIKTEHNGLQnLARRI 540
Cdd:smart00387   9 VLSNLLDNAIKYTPE---GGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIfepffRTDKRSRKIGGTGLGLS-IVKKL 84

                           90       100
                   ....*....|....*....|....*..
gi 2214426814  541 VLEYGeGSgMSIDSMEGEYFKVTVRLK 567
Cdd:smart00387  85 VELHG-GE-ISVESEPGGGTTFTITLP 109
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
470-566 3.52e-07

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 51.45  E-value: 3.52e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214426814 470 LIENSIKYGFKkrmDIAVAIRGWCEEDSMVLTVEDNGPGVPRTTLETLRTMLASEEIKTEHN----GLqNLARRIVLEYG 545
Cdd:COG2205   140 LLDNAIKYSPP---GGTITISARREGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRGEGgtglGL-AIVKRIVEAHG 215

                          90       100
                  ....*....|....*....|.
gi 2214426814 546 eGSgMSIDSMEGEYFKVTVRL 566
Cdd:COG2205   216 -GT-IWVESEPGGGTTFTVTL 234
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 464-570 4.55e-07

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 48.52  E-value: 4.55e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214426814 464 KLLLQPLIENSIKYGFKKRmDIAVAIRgwcEEDSMVLTVEDNGPGVPRTTLETLRTMLASEE-IKTEHNGLQ-NLARRIV 541
Cdd:pfam02518   7 RQVLSNLLDNALKHAAKAG-EITVTLS---EGGELTLTVEDNGIGIPPEDLPRIFEPFSTADkRGGGGTGLGlSIVRKLV 82

                          90       100
                  ....*....|....*....|....*....
gi 2214426814 542 LEYGeGSgMSIDSMEGEYFKVTVRLKHRE 570
Cdd:pfam02518  83 ELLG-GT-ITVESEPGGGTTVTLTLPLAQ 109
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
450-566 2.36e-06

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 49.91  E-value: 2.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214426814 450 SIDIQEECNRYNVPKLLLQP----LIENSIKYGFKKRMdiaVAIRGWCEEDSMVLTVEDNGPGVPRTTLETLRTMLASEE 525
Cdd:COG0642   207 ELDLPDDLPTVRGDPDRLRQvllnLLSNAIKYTPEGGT---VTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTD 283

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2214426814 526 IKTEHN----GLqNLARRIVLEYGeGSgMSIDSMEGEYFKVTVRL 566
Cdd:COG0642   284 PSRRGGgtglGL-AIVKRIVELHG-GT-IEVESEPGKGTTFTVTL 325
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 282-369 3.52e-06

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 49.58  E-value: 3.52e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214426814 282 ILTIIFLGVLWFLMSLRLTRGMAERNARSVNLLADELRIIRHGDSGHTVTISTGDEFEEIANHINRMVKSINELNTRNTD 361
Cdd:COG5000     8 LLLLLLIALLLLLLALWLALLLARRLTRPLRRLAEATRAVAAGDLSVRLPVTGDDEIGELARAFNRMTDQLKEQREELEE 87


                  ....*...
gi 2214426814 362 LIRLNSMI 369
Cdd:COG5000    88 RRRYLETI 95
NarQ COG3850
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ...
 280-413 7.57e-05

Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];


Pssm-ID: 443059 [Multi-domain]  Cd Length: 448  Bit Score: 45.26  E-value: 7.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214426814 280 IGILTIIFLGVLWFLMSLRLTRgmaernarSVNLLADELRIIRHGDSGHTVTISTGDEFEEIANHINRMVKSINELN--- 356
Cdd:COG3850   123 RLLLALLLALLLAYLLRRRIVR--------PLRRLTQAAERIARGDFDARVPVSGRDELGTLARAFNRMADELQELYael 194

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2214426814 357 TRNTDLIRLNSMIEMSNLQTQINPHFIYNTLDNIKYLIFSEPDKAAYLIERFTHILR 413
Cdd:COG3850   195 EEEEELEAELELLALLDELLLLAALLLLLALLLALLLAALLAALLLLLLLQDALAES 251
HAMP pfam00672
HAMP domain;
309-354 1.02e-04

HAMP domain;


Pssm-ID: 459898 [Multi-domain]  Cd Length: 53  Bit Score: 40.30  E-value: 1.02e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2214426814 309 RSVNLLADELRIIRHGDSGHTVTISTGDEFEEIANHINRMVKSINE 354
Cdd:pfam00672   8 RPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERLRE 53
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
487-566 1.14e-04

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 43.84  E-value: 1.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214426814 487 VAIRGWCEEDSMVLTVEDNGPGvprttletlrtmLASEEIKTEHNGLQNLARRIVLEYGEgsgMSIDSMEGEYFKVTVRL 566
Cdd:COG4585   183 VTVTLEVDDGELTLTVRDDGVG------------FDPEAAPGGGLGLRGMRERAEALGGT---LTIGSAPGGGTRVRATL 247
HAMP cd06225
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ...
 309-352 2.17e-04

Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.


Pssm-ID: 381743 [Multi-domain]  Cd Length: 45  Bit Score: 38.96  E-value: 2.17e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2214426814 309 RSVNLLADELRIIRHGDSGHTVTISTGDEFEEIANHINRMVKSI 352
Cdd:cd06225     2 RPLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
280-355 3.12e-04

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 43.47  E-value: 3.12e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2214426814 280 IGILTIIFLGVLWFLMSLRLTRGMAERNARSVNLLADELRIIRHGDSGHTVTISTGDEFEEIANHINRMVKSINEL 355
Cdd:COG0840   179 LALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLADAFNRMIENLREL 254
HATPase_BvrS-ChvG-like cd16953
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 466-545 3.34e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.


Pssm-ID: 340429 [Multi-domain]  Cd Length: 110  Bit Score: 40.25  E-value: 3.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214426814 466 LLQPLIENSIKYGFKKRMDIAVAIRGwcEEDSMVLTVEDNGPGVPRTTLETLRTMLASEEIKTE----HNGLQ-NLARRI 540
Cdd:cd16953     4 VLRNLIGNAISFSPPDTGRITVSAMP--TGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANEafgqHSGLGlSISRQI 81


                  ....*
gi 2214426814 541 VLEYG 545
Cdd:cd16953    82 IEAHG 86
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 470-510 3.47e-04

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 43.36  E-value: 3.47e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2214426814 470 LIENSIKYGFKKRMDIAVAIRGWCEEDSMVLTVEDNGPGVP 510
Cdd:COG3920   407 LVTNALKHAFLSGEGGRIRVSWRREDGRLRLTVSDNGVGLP 447
HAMP smart00304
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
308-355 8.29e-04

HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;


Pssm-ID: 197640 [Multi-domain]  Cd Length: 53  Bit Score: 37.61  E-value: 8.29e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 2214426814  308 ARSVNLLADELRIIRHGDSGHTVTISTGDEFEEIANHINRMVKSINEL 355
Cdd:smart00304   4 LRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLEET 51
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 464-517 1.77e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 38.54  E-value: 1.77e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2214426814 464 KLLLQPLIENSIKY-GFKKRMDIAVAirgwcEEDSMVLTVEDNGPGVPRTTLETL 517
Cdd:cd16940    15 FLLLRNLVDNAVRYsPQGSRVEIKLS-----ADDGAVIRVEDNGPGIDEEELEAL 64
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 286-515 1.79e-03

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 40.94  E-value: 1.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214426814 286 IFLGVLWFLMSLRLTRGMAERNARSVNLLADELRIIRHGDSGHTVTISTGDEFEEIANHINRMVKSINELNTRNTDLI-- 363
Cdd:COG4191    57 LLLLLLELLLLLLALLGGLLRLLLLLGLLLLLLLEALLLLLLAALDAEENAELEELERDITELERAEEELRELQEQLVqs 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214426814 364 -RLNSMIEMS-------NlqtqiNP-HFIYNTLDNIKYLIFSEPDKAaYLIERFTHI--------------LRYSINNTK 420
Cdd:COG4191   137 eKLAALGELAagiaheiN-----NPlAAILGNAELLRRRLEDEPDPE-ELREALERIlegaeraaeivrslRAFSRRDEE 210

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214426814 421 HDVPLyeDM-EYIQDYLYIQNTRFGSRfvcSIDIQEECNRyNVPKLLLQP---------LIENSIkYGFKKRMDIAVAIR 490
Cdd:COG4191   211 EREPV--DLnELIDEALELLRPRLKAR---GIEVELDLPP-DLPPVLGDPgqleqvllnLLINAI-DAMEEGEGGRITIS 283

                         250       260
                  ....*....|....*....|....*
gi 2214426814 491 GWCEEDSMVLTVEDNGPGVPRTTLE 515
Cdd:COG4191   284 TRREGDYVVISVRDNGPGIPPEVLE 308
PRK10490 PRK10490
sensor protein KdpD; Provisional
 467-510 2.20e-03

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 41.17  E-value: 2.20e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2214426814 467 LQPLIENSIKYGFKkrmDIAVAIRGWCEEDSMVLTVEDNGPGVP 510
Cdd:PRK10490  783 LINLLENAVKYAGA---QAEIGIDAHVEGERLQLDVWDNGPGIP 823
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
470-515 3.55e-03

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 37.97  E-value: 3.55e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2214426814 470 LIENSIKYGFKKRMDIAVAIRGWCEEDSMVLTVEDNGPGVPRTTLE 515
Cdd:COG2172    42 AVTNAVRHAYGGDPDGPVEVELELDPDGLEIEVRDEGPGFDPEDLP 87
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
470-510 3.62e-03

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 39.92  E-value: 3.62e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2214426814 470 LIENSIKYGfkkRMDIAVAIRGWCEEDSMVLTVEDNGPGVP 510
Cdd:COG5002   289 LLDNAIKYT---PEGGTITVSLREEDDQVRISVRDTGIGIP 326
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 466-510 3.66e-03

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 40.15  E-value: 3.66e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2214426814 466 LLQPLIENSIKYGfKKRMDIAVAIRGWCEEDSMVLTVEDNGPGVP 510
Cdd:COG4251   398 VFQNLISNAIKYS-RPGEPPRIEIGAEREGGEWVFSVRDNGIGID 441
cpxA PRK09470
envelope stress sensor histidine kinase CpxA;
463-515 4.53e-03

envelope stress sensor histidine kinase CpxA;


Pssm-ID: 236532 [Multi-domain]  Cd Length: 461  Bit Score: 39.53  E-value: 4.53e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2214426814 463 PKLL---LQPLIENSIKYGFKKrmdIAVAIRgwCEEDSMVLTVEDNGPGVPRTTLE 515
Cdd:PRK09470  351 PNALasaLENIVRNALRYSHTK---IEVAFS--VDKDGLTITVDDDGPGVPEEERE 401
HATPase_EcPhoR-like cd16952
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 470-517 6.49e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.


Pssm-ID: 340428 [Multi-domain]  Cd Length: 108  Bit Score: 36.80  E-value: 6.49e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2214426814 470 LIENSIKYgfkKRMDIAVAIRGWCEEDSMVLTVEDNGPGVPRTTLETL 517
Cdd:cd16952     8 LVSNAVKY---TPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRL 52
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 467-510 8.86e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 36.25  E-value: 8.86e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2214426814 467 LQPLIENSIKYGfKKRMDIAVAIRGwceeDSMVLTVEDNGPGVP 510
Cdd:cd16939     5 LDNLLRNALRYA-HRTVRIALLVSG----GRLTLIVEDDGPGIP 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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