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Conserved domains on  [gi|2215681407|ref|WP_243185375|]
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class I SAM-dependent methyltransferase [Clostridium tetani]

Protein Classification

tRNA (mnm(5)s(2)U34)-methyltransferase( domain architecture ID 10536603)

tRNA (mnm(5)s(2)U34)-methyltransferase catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34 to form mnm(5)s(2)U34

CATH:  2.20.25.110
EC:  2.1.1.61
Gene Ontology:  GO:0004808|GO:1904047|GO:0008033|GO:0032259|GO:0008757
PubMed:  12826405|12504684
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
rRNA_methylase pfam06962
Putative rRNA methylase; This family contains a number of putative rRNA methylases. Note that ...
 54-189 6.13e-74

Putative rRNA methylase; This family contains a number of putative rRNA methylases. Note that many family members are hypothetical proteins.


:

Pssm-ID: 429214  Cd Length: 137  Bit Score: 218.82  E-value: 6.13e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215681407  54 VYSFDIQMEALKSTENKLYQNNIHW-AELILDGHENMDKYLKEEPKIILFNLGYLPGNSKEVTTKKDTTLEAVKKSLDLI 132
Cdd:pfam06962   1 VYAFDIQEEALENTRERLEEEGLEErVELILDGHENLDEYVPGPVDAAMFNLGYLPGGDKSITTKPETTLKALEAALELL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2215681407 133 KKEGVIILVIYPGHEEGMLEKKALIDFCKGICQKQFNVIKLQFVNQINNPPMMICIE 189
Cdd:pfam06962  81 KPGGIISLVVYPGHPGGKEEKEAVLEYLSSLDQKKYNVLKYEFLNQPNNPPFLVLIE 137
Gcd14 super family cl34476
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 24-65 3.15e-03

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


The actual alignment was detected with superfamily member COG2519:

Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 37.06  E-value: 3.15e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2215681407  24 LKKGDIAVDATMGNGNDTLFLCKLVEEEGKVYSFDIQMEALK 65
Cdd:COG2519    89 IFPGARVLEAGTGSGALTLALARAVGPEGKVYSYERREDFAE 130
 
Name Accession Description Interval E-value
rRNA_methylase pfam06962
Putative rRNA methylase; This family contains a number of putative rRNA methylases. Note that ...
 54-189 6.13e-74

Putative rRNA methylase; This family contains a number of putative rRNA methylases. Note that many family members are hypothetical proteins.


Pssm-ID: 429214  Cd Length: 137  Bit Score: 218.82  E-value: 6.13e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215681407  54 VYSFDIQMEALKSTENKLYQNNIHW-AELILDGHENMDKYLKEEPKIILFNLGYLPGNSKEVTTKKDTTLEAVKKSLDLI 132
Cdd:pfam06962   1 VYAFDIQEEALENTRERLEEEGLEErVELILDGHENLDEYVPGPVDAAMFNLGYLPGGDKSITTKPETTLKALEAALELL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2215681407 133 KKEGVIILVIYPGHEEGMLEKKALIDFCKGICQKQFNVIKLQFVNQINNPPMMICIE 189
Cdd:pfam06962  81 KPGGIISLVVYPGHPGGKEEKEAVLEYLSSLDQKKYNVLKYEFLNQPNNPPFLVLIE 137
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 24-65 3.15e-03

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 37.06  E-value: 3.15e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2215681407  24 LKKGDIAVDATMGNGNDTLFLCKLVEEEGKVYSFDIQMEALK 65
Cdd:COG2519    89 IFPGARVLEAGTGSGALTLALARAVGPEGKVYSYERREDFAE 130
 
Name Accession Description Interval E-value
rRNA_methylase pfam06962
Putative rRNA methylase; This family contains a number of putative rRNA methylases. Note that ...
 54-189 6.13e-74

Putative rRNA methylase; This family contains a number of putative rRNA methylases. Note that many family members are hypothetical proteins.


Pssm-ID: 429214  Cd Length: 137  Bit Score: 218.82  E-value: 6.13e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215681407  54 VYSFDIQMEALKSTENKLYQNNIHW-AELILDGHENMDKYLKEEPKIILFNLGYLPGNSKEVTTKKDTTLEAVKKSLDLI 132
Cdd:pfam06962   1 VYAFDIQEEALENTRERLEEEGLEErVELILDGHENLDEYVPGPVDAAMFNLGYLPGGDKSITTKPETTLKALEAALELL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2215681407 133 KKEGVIILVIYPGHEEGMLEKKALIDFCKGICQKQFNVIKLQFVNQINNPPMMICIE 189
Cdd:pfam06962  81 KPGGIISLVVYPGHPGGKEEKEAVLEYLSSLDQKKYNVLKYEFLNQPNNPPFLVLIE 137
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 24-65 3.15e-03

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 37.06  E-value: 3.15e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2215681407  24 LKKGDIAVDATMGNGNDTLFLCKLVEEEGKVYSFDIQMEALK 65
Cdd:COG2519    89 IFPGARVLEAGTGSGALTLALARAVGPEGKVYSYERREDFAE 130
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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