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Conserved domains on  [gi|2218224101|ref|WP_243533716.1|]
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OsmC family protein

Protein Classification

OsmC family protein( domain architecture ID 10022664)

OsmC (osmotically inducible protein C) family protein may function as a peroxiredoxin or hydroperoxide reductase, catalyzing the reduction of organic and inorganic peroxide substrates to protect the cell against oxidative stress

Gene Ontology:  GO:0004601|GO:0033194|GO:0006979|GO:0005829|GO:0006972|GO:0051920
PubMed:  11429455

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
osmo_induc_OsmC TIGR03562
peroxiredoxin, OsmC subfamily; pfam02566, OsmC-like protein, contains several deeply split ...
 5-138 3.37e-74

peroxiredoxin, OsmC subfamily; pfam02566, OsmC-like protein, contains several deeply split clades of homologous proteins. The clade modeled here includes the protein OsmC, or osmotically induced protein C. The member from Thermus thermophilus was shown to have hydroperoxide peroxidase activity. In many species, this protein is induced by stress and helps resist oxidative stress. [Cellular processes, Detoxification]


:

Pssm-ID: 274650  Cd Length: 135  Bit Score: 217.46  E-value: 3.37e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2218224101   5 KTANSTWSGDIKTGKGSISTQSGALDKQPYGFNTRFEDEPGSNPEELVGAAHSACFSMALSLALGDAGFTADKIDTKATV 84
Cdd:TIGR03562   1 RTASAVWEGDLKEGKGTISTQSGALSETPYSFKTRFEDGPGTNPEELIAAAHAGCFSMALSAALAEAGFTPESLDTTATV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2218224101  85 SLDEVDDGFAVTHIALEVKARISDIANEQFQALCEQTKKGCPISKLLN-TEISLK 138
Cdd:TIGR03562  81 TLDKVGGGFAITGIHLTVRAKVPGIDEAKFQEIAEKAKEGCPVSKALAaVEITLD 135
 
Name Accession Description Interval E-value
osmo_induc_OsmC TIGR03562
peroxiredoxin, OsmC subfamily; pfam02566, OsmC-like protein, contains several deeply split ...
 5-138 3.37e-74

peroxiredoxin, OsmC subfamily; pfam02566, OsmC-like protein, contains several deeply split clades of homologous proteins. The clade modeled here includes the protein OsmC, or osmotically induced protein C. The member from Thermus thermophilus was shown to have hydroperoxide peroxidase activity. In many species, this protein is induced by stress and helps resist oxidative stress. [Cellular processes, Detoxification]


Pssm-ID: 274650  Cd Length: 135  Bit Score: 217.46  E-value: 3.37e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2218224101   5 KTANSTWSGDIKTGKGSISTQSGALDKQPYGFNTRFEDEPGSNPEELVGAAHSACFSMALSLALGDAGFTADKIDTKATV 84
Cdd:TIGR03562   1 RTASAVWEGDLKEGKGTISTQSGALSETPYSFKTRFEDGPGTNPEELIAAAHAGCFSMALSAALAEAGFTPESLDTTATV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2218224101  85 SLDEVDDGFAVTHIALEVKARISDIANEQFQALCEQTKKGCPISKLLN-TEISLK 138
Cdd:TIGR03562  81 TLDKVGGGFAITGIHLTVRAKVPGIDEAKFQEIAEKAKEGCPVSKALAaVEITLD 135
OsmC COG1764
Organic hydroperoxide reductase OsmC/OhrA [Defense mechanisms];
1-141 9.22e-49

Organic hydroperoxide reductase OsmC/OhrA [Defense mechanisms];


Pssm-ID: 441370  Cd Length: 140  Bit Score: 153.06  E-value: 9.22e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2218224101   1 MTIKKTANSTWSGDikTGKGSISTQSGALDkQPYGFNTRF-EDEPGSNPEELVGAAHSACFSMALSLALGDAGFTADKID 79
Cdd:COG1764     1 MKRLYTATATWTGN--RGDGTVSSEDGGLD-LPLSSPPEFgGDGTGTNPEELLAAAYAACFMLALLAVAAQAGVTVESYE 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2218224101  80 TKATVSLDEVDDG-FAVTHIALEVKARISDIANEQFQALCEQTKKGCPISKLLNTEISLKATL 141
Cdd:COG1764    78 VTAEVTLGKDDDGgFAFTGITLRLRVTVPGLDREKAEELVEKAHEVCPISNALRGNITVELTL 140
OsmC pfam02566
OsmC-like protein; Osmotically inducible protein C (OsmC) is a stress -induced protein found ...
 47-138 7.36e-17

OsmC-like protein; Osmotically inducible protein C (OsmC) is a stress -induced protein found in E. Coli. This family also contains a organic hydroperoxide detoxification protein that has a novel pattern of oxidative stress regulation.


Pssm-ID: 460594  Cd Length: 99  Bit Score: 70.81  E-value: 7.36e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2218224101  47 NPEELVGAAHSACFSMALSLALGDAGFTADKIDTKATVSLDEvDDGFAVTHIALEVKARISDIANEQFQALCEQTKKGCP 126
Cdd:pfam02566   7 NPEELLLAALASCFAITLRAIAKKKGIKLEDLEVEVEGERDP-EGALGFTEIRLRVEVKTPDADEEKLKKLLELAEKKCP 85

                          90
                  ....*....|..
gi 2218224101 127 ISKLLNTEISLK 138
Cdd:pfam02566  86 VANTLKNGIKVE 97
 
Name Accession Description Interval E-value
osmo_induc_OsmC TIGR03562
peroxiredoxin, OsmC subfamily; pfam02566, OsmC-like protein, contains several deeply split ...
 5-138 3.37e-74

peroxiredoxin, OsmC subfamily; pfam02566, OsmC-like protein, contains several deeply split clades of homologous proteins. The clade modeled here includes the protein OsmC, or osmotically induced protein C. The member from Thermus thermophilus was shown to have hydroperoxide peroxidase activity. In many species, this protein is induced by stress and helps resist oxidative stress. [Cellular processes, Detoxification]


Pssm-ID: 274650  Cd Length: 135  Bit Score: 217.46  E-value: 3.37e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2218224101   5 KTANSTWSGDIKTGKGSISTQSGALDKQPYGFNTRFEDEPGSNPEELVGAAHSACFSMALSLALGDAGFTADKIDTKATV 84
Cdd:TIGR03562   1 RTASAVWEGDLKEGKGTISTQSGALSETPYSFKTRFEDGPGTNPEELIAAAHAGCFSMALSAALAEAGFTPESLDTTATV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2218224101  85 SLDEVDDGFAVTHIALEVKARISDIANEQFQALCEQTKKGCPISKLLN-TEISLK 138
Cdd:TIGR03562  81 TLDKVGGGFAITGIHLTVRAKVPGIDEAKFQEIAEKAKEGCPVSKALAaVEITLD 135
OsmC COG1764
Organic hydroperoxide reductase OsmC/OhrA [Defense mechanisms];
1-141 9.22e-49

Organic hydroperoxide reductase OsmC/OhrA [Defense mechanisms];


Pssm-ID: 441370  Cd Length: 140  Bit Score: 153.06  E-value: 9.22e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2218224101   1 MTIKKTANSTWSGDikTGKGSISTQSGALDkQPYGFNTRF-EDEPGSNPEELVGAAHSACFSMALSLALGDAGFTADKID 79
Cdd:COG1764     1 MKRLYTATATWTGN--RGDGTVSSEDGGLD-LPLSSPPEFgGDGTGTNPEELLAAAYAACFMLALLAVAAQAGVTVESYE 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2218224101  80 TKATVSLDEVDDG-FAVTHIALEVKARISDIANEQFQALCEQTKKGCPISKLLNTEISLKATL 141
Cdd:COG1764    78 VTAEVTLGKDDDGgFAFTGITLRLRVTVPGLDREKAEELVEKAHEVCPISNALRGNITVELTL 140
OsmC pfam02566
OsmC-like protein; Osmotically inducible protein C (OsmC) is a stress -induced protein found ...
 47-138 7.36e-17

OsmC-like protein; Osmotically inducible protein C (OsmC) is a stress -induced protein found in E. Coli. This family also contains a organic hydroperoxide detoxification protein that has a novel pattern of oxidative stress regulation.


Pssm-ID: 460594  Cd Length: 99  Bit Score: 70.81  E-value: 7.36e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2218224101  47 NPEELVGAAHSACFSMALSLALGDAGFTADKIDTKATVSLDEvDDGFAVTHIALEVKARISDIANEQFQALCEQTKKGCP 126
Cdd:pfam02566   7 NPEELLLAALASCFAITLRAIAKKKGIKLEDLEVEVEGERDP-EGALGFTEIRLRVEVKTPDADEEKLKKLLELAEKKCP 85

                          90
                  ....*....|..
gi 2218224101 127 ISKLLNTEISLK 138
Cdd:pfam02566  86 VANTLKNGIKVE 97
YhfA COG1765
Uncharacterized OsmC-related protein [General function prediction only];
42-141 2.51e-10

Uncharacterized OsmC-related protein [General function prediction only];


Pssm-ID: 441371  Cd Length: 126  Bit Score: 54.47  E-value: 2.51e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2218224101  42 DEP--------GSNPEELVGAAHSACFSMALSLALGDAGFTADKIDTKATVSLDEVDDGFAVTHIALEVKARISDianEQ 113
Cdd:COG1765    21 DEPpelggtdtGPSPVELLLAALAGCTAITVRMIAKKKGIDLEGLEVEVEGDRDEEPKGFTKIRVTITVDGDLSE---EQ 97

                          90       100
                  ....*....|....*....|....*...
gi 2218224101 114 FQALCEQTKKGCPISKLLNTEISLKATL 141
Cdd:COG1765    98 LERLLELAEKYCPVSDTLRNGVEITTEL 125
organ_hyd_perox TIGR03561
peroxiredoxin, Ohr subfamily; pfam02566, OsmC-like protein, contains several deeply split ...
 45-129 1.15e-09

peroxiredoxin, Ohr subfamily; pfam02566, OsmC-like protein, contains several deeply split clades of homologous proteins. The clade modeled here includes the protein Ohr, or organic hydroperoxide resistance protein. [Cellular processes, Detoxification]


Pssm-ID: 274649  Cd Length: 134  Bit Score: 52.95  E-value: 1.15e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2218224101  45 GSNPEELVGAAHSACFSMALSLALGDAGFT-ADKIDTKATVSLDEVDD-GFAvthIALEVKARISDIANEQFQALCEQTK 122
Cdd:TIGR03561  39 GTNPEQLFAAGYAACFDGALKLVAGQAKVKlPADAEVTATVGLGKNEDgGFG---LSVELKVTLPGLDQAEAEALVEAAH 115


                  ....*..
gi 2218224101 123 KGCPISK 129
Cdd:TIGR03561 116 QVCPYSK 122
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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