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Conserved domains on  [gi|2221774916|ref|WP_244399789|]
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MULTISPECIES: exodeoxyribonuclease V subunit beta [unclassified Agrobacterium]

Protein Classification

UvrD-helicase domain-containing protein( domain architecture ID 11437585)

UvrD-helicase domain-containing protein catalyzes the unwinding of DNA; similar to exodeoxyribonuclease V subunit beta (RecB), a component of the heterotrimeric RecBCD helicase/nuclease complex that is essential for double-strand DNA break repair and recombination

CATH:  3.40.50.300
EC:  3.1.11.5|3.6.4.-
Gene Ontology:  GO:0016887|GO:0005524|GO:0004386|GO:0003677
PubMed:  21428912
SCOP:  3002019

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RecB COG1074
3#-5# helicase subunit RecB of the DNA repair enzyme RecBCD (exonuclease V) [Replication, ...
 3-1045 4.80e-100

3#-5# helicase subunit RecB of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair];


:

Pssm-ID: 440692 [Multi-domain]  Cd Length: 866  Bit Score: 336.16  E-value: 4.80e-100
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916    3 QGLVIVPAGAGAGKTHRIKTQLSDWVKRGVVRPERILAVTFTETAAAELRERIRAGLLADGLVSEAMAVE---------- 72
Cdd:COG1074     18 GGSVLVEASAGSGKTYTLVARYLRLLLERGLDPEEILVVTFTRAAAAEMRERIRERLAEAADLEDPDLEElararrrlar 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916   73 ------RAYVSTIHGLGLRLLTEHALAAGASPQPRHLGDAErDLLIRQSLAhaksldtikaeperfgyeanwqtgntved 146
Cdd:COG1074     98 alenldRAAISTIHSFCQRLLREFAFEAGLDPNFELLDDAE-ALLLEEAVD----------------------------- 147

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  147 slrgrvlsmiDLLRGLGDKGRdrgllAPALSRLDTIYGNvlsdptaaraalgaaiqtmvasfpeggkahitakgNVEKLE 226
Cdd:COG1074    148 ----------DLLREAYAPLD-----ALALARLLDAFGR-----------------------------------DDDSLE 177

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  227 KDLALFKRVHRSPDLLDRDWKLWNDLRGLfvsnrssktpegyddLATAIMAAADVLPAHPGPLADAKLHLSCLISCAQEV 306
Cdd:COG1074    178 ELLLALYKLRSRPDWLEELAELDEALEAL---------------REALLKAKEALAALREALAAAAAPLLAALLRLLAAV 242

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  307 MEAYETRKKALGLIDFADMITGAERLLRTD--PAVLQAVLGEIDCVIIDEFQDTNPVQFALLWQL---GANATRTL-LVG 380
Cdd:COG1074    243 LARYERRKRERGLLDFDDLLHRALRLLRDEdaPWVAERLRERYRHILVDEFQDTSPLQWEILRRLageALADGRTLfLVG 322

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  381 DVKQSIMGFQGADPRL----SQALATANPDATQPLDRNWRSTPAVMKFVNA-----MGVGLFGALYNSLTPTRDHiSCPA 451
Cdd:COG1074    323 DPKQSIYRFRGADPELfleaRRALEGRVDGERLTLTTNFRSTPEVVDAVNAlfaqlMGAGFGEIPYEPVEALRPG-AYPA 401

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  452 LEVLIATKSRGVRNASKPQE--HIAERIARILTDGDTITDRiskaSRPARPSDIALLVCRHTTAARYAEELRARSVPVRI 529
Cdd:COG1074    402 VELWPLEPDDVSEEDAREREarAVAARIRRLLAEGTTVEGG----GRPVRPGDIAVLVRTRSEAAAIARALKAAGIPVAA 477

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  530 SE-DGWATSPVVAaaraalafaanpaDVHSGL--------------LLRT--LGPDPLPLQTATSAQTEGRLGD------ 586
Cdd:COG1074    478 SDrLSLFESPEVR-------------DLLALLrallnpeddlalaaVLRSplFGLSDEDLAALAADRKGESLWEalraye 544

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  587 --DPVLIRLSALSDKMASLPIGAALDLVLSVAGLRLWADCQPNAAASRADLLRLEA---EANEFERAHRDlkaasGFHGe 661
Cdd:COG1074    545 rlARALERLRALRELARRLGLAELLERLLEETGLLERLLALPGGERRLANLLHLDEllqLALEYEQTGGP-----GLAG- 618

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  662 takvFLGWLDARANERDfDRRPDPAANNAEAVEIVTWHASKGREWPITVVAEldngiedwpgstttrfdALDRIDDmavv 741
Cdd:COG1074    619 ----FLRWLERLIEDGG-DEEKRRLESDADAVRIMTIHKSKGLEFPVVFLPA-----------------LRERARA---- 672

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  742 lgsaalvhtpgfaapeatRRFIEDRRedfeanaknLLYVALTRARDRIVLEWPGFLKDREKDapeatnlfhvftdncapq 821
Cdd:COG1074    673 ------------------EELAEELR---------LLYVALTRARDRLVLSGAVKKKDAEKE------------------ 707

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  822 igtnclkiggvncaavikqlpemagftefassvssvpprfgpatplaeiplSPWRlqpsqsrsagevpgtrsiilgapwp 901
Cdd:COG1074    708 ---------------------------------------------------SSWL------------------------- 711

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  902 ttlndAARGTALH-----LALRTYLTRPDLAHGLPSATGLEEATLGMISERATA------LKDWLAAEgytDLATEIPVL 970
Cdd:COG1074    712 -----ARRGTLVHrllehLDFSAPAELRAALARLLARGGLDEEEAEALAEALLAflatplLAELFAAA---EVLREVPFL 783

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  971 G---YTRDGAEIPGIIDLLAMGSNGCLLIDHKSGGSGEGLGP-----YWPQLSSYAGLVPELFPQHPLKGvAVLWVDHGR 1042
Cdd:COG1074    784 LpdlYRGLGGLLKGRIDLVFEDDGRVYIVDYKTNRLGPDDEEylperYRLQLALYALALERLLPGRPVRA-GLYFTDRGR 862


                   ...
gi 2221774916 1043 LEL 1045
Cdd:COG1074    863 LVE 865
 
Name Accession Description Interval E-value
RecB COG1074
3#-5# helicase subunit RecB of the DNA repair enzyme RecBCD (exonuclease V) [Replication, ...
 3-1045 4.80e-100

3#-5# helicase subunit RecB of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair];


Pssm-ID: 440692 [Multi-domain]  Cd Length: 866  Bit Score: 336.16  E-value: 4.80e-100
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916    3 QGLVIVPAGAGAGKTHRIKTQLSDWVKRGVVRPERILAVTFTETAAAELRERIRAGLLADGLVSEAMAVE---------- 72
Cdd:COG1074     18 GGSVLVEASAGSGKTYTLVARYLRLLLERGLDPEEILVVTFTRAAAAEMRERIRERLAEAADLEDPDLEElararrrlar 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916   73 ------RAYVSTIHGLGLRLLTEHALAAGASPQPRHLGDAErDLLIRQSLAhaksldtikaeperfgyeanwqtgntved 146
Cdd:COG1074     98 alenldRAAISTIHSFCQRLLREFAFEAGLDPNFELLDDAE-ALLLEEAVD----------------------------- 147

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  147 slrgrvlsmiDLLRGLGDKGRdrgllAPALSRLDTIYGNvlsdptaaraalgaaiqtmvasfpeggkahitakgNVEKLE 226
Cdd:COG1074    148 ----------DLLREAYAPLD-----ALALARLLDAFGR-----------------------------------DDDSLE 177

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  227 KDLALFKRVHRSPDLLDRDWKLWNDLRGLfvsnrssktpegyddLATAIMAAADVLPAHPGPLADAKLHLSCLISCAQEV 306
Cdd:COG1074    178 ELLLALYKLRSRPDWLEELAELDEALEAL---------------REALLKAKEALAALREALAAAAAPLLAALLRLLAAV 242

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  307 MEAYETRKKALGLIDFADMITGAERLLRTD--PAVLQAVLGEIDCVIIDEFQDTNPVQFALLWQL---GANATRTL-LVG 380
Cdd:COG1074    243 LARYERRKRERGLLDFDDLLHRALRLLRDEdaPWVAERLRERYRHILVDEFQDTSPLQWEILRRLageALADGRTLfLVG 322

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  381 DVKQSIMGFQGADPRL----SQALATANPDATQPLDRNWRSTPAVMKFVNA-----MGVGLFGALYNSLTPTRDHiSCPA 451
Cdd:COG1074    323 DPKQSIYRFRGADPELfleaRRALEGRVDGERLTLTTNFRSTPEVVDAVNAlfaqlMGAGFGEIPYEPVEALRPG-AYPA 401

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  452 LEVLIATKSRGVRNASKPQE--HIAERIARILTDGDTITDRiskaSRPARPSDIALLVCRHTTAARYAEELRARSVPVRI 529
Cdd:COG1074    402 VELWPLEPDDVSEEDAREREarAVAARIRRLLAEGTTVEGG----GRPVRPGDIAVLVRTRSEAAAIARALKAAGIPVAA 477

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  530 SE-DGWATSPVVAaaraalafaanpaDVHSGL--------------LLRT--LGPDPLPLQTATSAQTEGRLGD------ 586
Cdd:COG1074    478 SDrLSLFESPEVR-------------DLLALLrallnpeddlalaaVLRSplFGLSDEDLAALAADRKGESLWEalraye 544

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  587 --DPVLIRLSALSDKMASLPIGAALDLVLSVAGLRLWADCQPNAAASRADLLRLEA---EANEFERAHRDlkaasGFHGe 661
Cdd:COG1074    545 rlARALERLRALRELARRLGLAELLERLLEETGLLERLLALPGGERRLANLLHLDEllqLALEYEQTGGP-----GLAG- 618

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  662 takvFLGWLDARANERDfDRRPDPAANNAEAVEIVTWHASKGREWPITVVAEldngiedwpgstttrfdALDRIDDmavv 741
Cdd:COG1074    619 ----FLRWLERLIEDGG-DEEKRRLESDADAVRIMTIHKSKGLEFPVVFLPA-----------------LRERARA---- 672

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  742 lgsaalvhtpgfaapeatRRFIEDRRedfeanaknLLYVALTRARDRIVLEWPGFLKDREKDapeatnlfhvftdncapq 821
Cdd:COG1074    673 ------------------EELAEELR---------LLYVALTRARDRLVLSGAVKKKDAEKE------------------ 707

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  822 igtnclkiggvncaavikqlpemagftefassvssvpprfgpatplaeiplSPWRlqpsqsrsagevpgtrsiilgapwp 901
Cdd:COG1074    708 ---------------------------------------------------SSWL------------------------- 711

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  902 ttlndAARGTALH-----LALRTYLTRPDLAHGLPSATGLEEATLGMISERATA------LKDWLAAEgytDLATEIPVL 970
Cdd:COG1074    712 -----ARRGTLVHrllehLDFSAPAELRAALARLLARGGLDEEEAEALAEALLAflatplLAELFAAA---EVLREVPFL 783

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  971 G---YTRDGAEIPGIIDLLAMGSNGCLLIDHKSGGSGEGLGP-----YWPQLSSYAGLVPELFPQHPLKGvAVLWVDHGR 1042
Cdd:COG1074    784 LpdlYRGLGGLLKGRIDLVFEDDGRVYIVDYKTNRLGPDDEEylperYRLQLALYALALERLLPGRPVRA-GLYFTDRGR 862


                   ...
gi 2221774916 1043 LEL 1045
Cdd:COG1074    863 LVE 865
addA_alphas TIGR02784
double-strand break repair helicase AddA, alphaproteobacterial type; AddAB, also called RexAB, ...
 8-1043 8.59e-38

double-strand break repair helicase AddA, alphaproteobacterial type; AddAB, also called RexAB, substitutes for RecBCD in several bacterial lineages. These DNA recombination proteins act before synapse and are particularly important for DNA repair of double-stranded breaks by homologous recombination. The term AddAB is used broadly, with AddA homologous between the alphaproteobacteria (as modeled here) and the Firmicutes, while the partner AddB proteins show no strong homology across the two groups of species. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 274298 [Multi-domain]  Cd Length: 1135  Bit Score: 154.08  E-value: 8.59e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916    8 VPAGAGAGKTHriktQLSDWVKRGV---VRPERILAVTFTETAAAELRERI--RAG----LLADGLVSEAMAVERAY--- 75
Cdd:TIGR02784   15 VSANAGSGKTH----VLTQRVIRLLlagTEPSKILCLTYTKAAAAEMQNRVfkRLGewavLDDADLRARLEALEGKRpda 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916   76 ---------------------VSTIHGLGLRLLTEHALAAGASPQPRHLGDAERDLLI----RQSLAHAKSLDTIKAEPe 130
Cdd:TIGR02784   91 aklaearrlfaraletpgglkIQTIHAFCEALLHQFPLEANVAGHFSVIDDRAAATLLeearRALLAGPAAPDDALADA- 169

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  131 rFGYEANWQTGNTVEDSLRGRVLS---MIDLLRGLGDKGRDRGLLA----PALSRLDTIYGNVLSDPTAARAALGAAIQT 203
Cdd:TIGR02784  170 -LATVLEAAGETGLEALLAEIVARrdaLMAFLDEAGGEGAEARLRRalglAPGDTAEDLLEAVWPLPGLPRLALALIAAL 248

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  204 MvasFPEGGKAHITAKgnveklekdLALFKRVHRSPDLLDRdwklWNDLRGLFV----SNRSSKTP-------------E 266
Cdd:TIGR02784  249 L---KSGGGSKDAAAA---------LSQLREAAAEPDPVAR----LDLLLGAFLtskgEPKSASFVikkaiqkslpdlaE 312

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  267 GYDDLATAIMAAADVLPAhpgpLADAKLHLSCLIsCAQEVMEAYETRKKALGLIDFADMITGAERLLrTDPAVLQAVL-- 344
Cdd:TIGR02784  313 ALEDAASRVEALRERLRA----LRMAQRTLAALR-LAARLLQRYARLKKARGLLDFNDLIERTVALL-ARPGAGAWVHyk 386

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  345 --GEIDCVIIDEFQDTNPVQFALLWQLGAN----------ATRTLL-VGDVKQSIMGFQGADP----RLSQALATANPDA 407
Cdd:TIGR02784  387 ldRGIDHILVDEAQDTSPEQWDIIQALAEEffsgegarsgVERTIFaVGDEKQSIYSFQGADPerfaEERREFSRKVRAV 466

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  408 TQPLDR-----NWRSTPAVMKFVNAM----GVGLFGALYNSLTPTR----DHISCPALEVLIATKSR------------- 461
Cdd:TIGR02784  467 GRKFEDlslnySFRSTPDVLAAVDLVfadpENARGLSADSDAPVHEafrdDLPGRVDLWDLISKEEGeepedwtdpvdel 546

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  462 GVRNAS-KPQEHIAERIARILTDGDTITDRiskaSRPARPSDIALLVcRHTTAARYA--EELRARSVPVRISEDGWATSP 538
Cdd:TIGR02784  547 GERAPEvRLAERIAAEIRAWLDRGTPIPGR----GRAVRPGDILVLV-RKRDAFFSAliRALKRRGIPVAGADRLKLTSH 621

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  539 --VVAAARAALAFAANPADVHSGLLLRT--LGPDPLPLQTATSAQTEGRL---------GDDPVLIRLSALSDKMASLPI 605
Cdd:TIGR02784  622 iaVKDLMALGRFVLQPEDDLSLAALLKSplFGLDEDDLFRLAAGRSGGSLwaalrrreaEFAATLAVLRDWLSLADFLTP 701

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  606 GAALDLVLSVAGLRlwadcqpnaaasRADLLRLEAEA----NEFERAHRDLKaASGFHGETAkvFLGWLDARANE--RDF 679
Cdd:TIGR02784  702 FEFYARLLGRDGGR------------RKLLARLGAEAedilDEFLSQALAYE-RTGLPGLQA--FLSWLEADDPEikREM 766

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  680 DRRPDpaannaeAVEIVTWHASKGREWPITVVAelDNGIEDWPGSTTTRFDALDRIDDMAVVLGSAALVHTPGFAAPeat 759
Cdd:TIGR02784  767 DQARD-------EVRVMTVHGAKGLEAPVVFLV--DTGSKPFASQRAPLLLATGGSGGKAPLWRPASAFDPSLSAAA--- 834

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  760 rrfIEDRREDFEANAKNLLYVALTRARDRIVLewPGFLKDREKDapeaTNLFHVFTDNCAPQIGTNCLKIGGVNCAAVIK 839
Cdd:TIGR02784  835 ---RERLKERAEDEYRRLLYVAMTRAEDRLIV--CGYRGKRESP----KDSWHALVKRALAAAGIAWQEPHPAQGKAEWR 905

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  840 Q------LPEMAGFTEFASSVSSVPPRFGPATPLAEIPLSPWRLQPS-QSRSAGEVPGTRSIILGAPWPTTLNDAARGTA 912
Cdd:TIGR02784  906 LrftrrdWDPVGLPVEAAQTDTLEALPDWLRAPAPAEPALPRPLAPSgLGGAIDSALPGEAVRSSLGTQAPAFALLRGTL 985

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  913 LHLALRtYL------TRPDLAHG-LPSATGLEEATlgmisERATALKDWLAAEGYTDLA--------TEIPVLG-YTRDG 976
Cdd:TIGR02784  986 LHRLLQ-HLpdlppeEREDAARRyLARSAADWPEA-----EREALLAAVLAVLDDPRLApvfapgsrAEVAIMGtLKEGG 1059

                         1130      1140      1150      1160      1170      1180      1190
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2221774916  977 AE--IPGIIDLLAMGSNGCLLIDHKSG----GSGEGLGP-YWPQLSSYAGLVPELFPQHPLKgVAVLWVDHGRL 1043
Cdd:TIGR02784 1060 QQlaVSGQIDRLAVDRDRVLIVDYKTNrpvpATAEEVPPaYLRQLALYRALLRPLYPGRAVE-AALLWTEAPKL 1132
UvrD-helicase pfam00580
UvrD/REP helicase N-terminal domain; The Rep family helicases are composed of four structural ...
 3-394 2.85e-31

UvrD/REP helicase N-terminal domain; The Rep family helicases are composed of four structural domains. The Rep family function as dimers. REP helicases catalyze ATP dependent unwinding of double stranded DNA to single stranded DNA. Swiss:P23478, Swiss:P08394 have large insertions near to the carboxy-terminus relative to other members of the family.


Pssm-ID: 395462 [Multi-domain]  Cd Length: 267  Bit Score: 123.89  E-value: 2.85e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916    3 QGLVIVPAGAGAGKT----HRIkTQLsdwVKRGVVRPERILAVTFTETAAAELRERIRAGLLADGLvseamavERAYVST 78
Cdd:pfam00580   13 GGPLLVLAGAGSGKTrvltERI-AYL---ILEGGIDPEEILAVTFTNKAAREMKERILKLLGKAEL-------SELNIST 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916   79 IHGLGLRLLtehalaagaspqprhlgdaerdllirqslahaksldtikaepERFGYEANWQTGNTVEDSLrgrvlsmidl 158
Cdd:pfam00580   82 FHSFCLRIL------------------------------------------RKYANRIGLLPNFSILDEL---------- 109

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  159 lrglgdkgrdrgllapalsrldtiygnvlsdptaaraalgaaiqtmvasfpeggkahitakgNVEKLEKDLALFKRVHRS 238
Cdd:pfam00580  110 --------------------------------------------------------------DQLALLKELLEKDRLNLD 127

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  239 PDLLdrdwklwndlRGLFVSNRSSKTPEGYddlataiMAAADVLPAHPGPLADAklhlscliscAQEVMEAYETRKKALG 318
Cdd:pfam00580  128 PKLL----------RKLELKELISKAKNRL-------LSPEELQQGAADPRDKL----------AAEFYQEYQERLKENN 180

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2221774916  319 LIDFADMITGAERLLRTDPAVLQAVLGEIDCVIIDEFQDTNPVQFALLWQLGANATRTLLVGDVKQSIMGFQGADP 394
Cdd:pfam00580  181 ALDFDDLLLLTLELLRSDPELLEAYRERFKYILVDEFQDTNPIQYRLLKLLAGGHENLFLVGDPDQSIYGFRGADI 256
DEXQc_UvrD cd17932
DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch ...
 320-415 1.29e-21

DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch repair, nucleotide excision repair, and recombinational repair. It plays a critical role in maintaining genomic stability and facilitating DNA lesion repair in many prokaryotic species including Helicobacter pylori and Escherichia coli. UvrD is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350690 [Multi-domain]  Cd Length: 189  Bit Score: 93.73  E-value: 1.29e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  320 IDFADMITGAERLLRTDPAVLQAVLGEIDCVIIDEFQDTNPVQFALLWQLGANATRTLLVGDVKQSIMGFQGADPRLSQA 399
Cdd:cd17932     93 GDFDDLLLYALELLEENPDVREKLQSRFRYILVDEYQDTNPLQYELLKLLAGDGKNLFVVGDDDQSIYGFRGADPENILD 172

                           90
                   ....*....|....*..
gi 2221774916  400 LATANPDATQ-PLDRNW 415
Cdd:cd17932    173 FEKDFPDAKViKLEENY 189
PRK13909 PRK13909
RecB-like helicase;
10-507 1.68e-14

RecB-like helicase;


Pssm-ID: 237554 [Multi-domain]  Cd Length: 910  Bit Score: 78.47  E-value: 1.68e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916   10 AGAGAGKTHriktQLSdwvkrgvVR----------PERILAVTFTETAAAELRERIRAGLLA---DGLVSEAMAVERAYv 76
Cdd:PRK13909     5 ASAGSGKTF----ALS-------VRflallfkganPSEILALTFTKKAANEMKERIIDTLLNlekEKEESELNELEEKL- 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916   77 stihGLGLRLLTEhalaagaspqprhlgdaERDLLIRQSLAHAKSLDTIKAeperF------------GYEANWQTGNTV 144
Cdd:PRK13909    73 ----GLSKEELLN-----------------KRDKVYQEFLNSELKISTIDA----FfqkilrkfclnlGLSPDFSIKEDT 127

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  145 EDSLRGRVLSMI---DLLRGL------GDKGrdrglLAPALSRLDTIYGNVlsdptaaraalgaaiqtmvASFPEGGKAH 215
Cdd:PRK13909   128 KEELNEKFLSALskeELLELLafikqcESKK-----NNSFFELLEKLYEKN-------------------NELKLFEKAK 183

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  216 ITAKGNVEK-LEKDLALFKRVHRSPDLLDRDWKLWN--DLRGLFVSNRSSKTPEG----YDDLATAIMaaadvlpahpgp 288
Cdd:PRK13909   184 NPIEFDEEKfLEELRSLKQQIQSIETASKNAKKAFKkeDFEELLNSSKTWLEKESeyryFKKLYNEEL------------ 251

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  289 laDAKLHlsCLISCAQEVMEAYETRK-------------------KALGLIDFADMITGAERLL------------RTDp 337
Cdd:PRK13909   252 --DAEFE--ELKNALKRYYDAKENYKlsklfkllqlykeaknelnKKKNALDFDDISKKVYELLgeeeidkdflyfRLD- 326

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  338 avlqavlGEIDCVIIDEFQDTNPVQFALLWQL--------GANATRTL-LVGDVKQSIMGFQGADPRLSQALATANPDAT 408
Cdd:PRK13909   327 -------SKISHILIDEFQDTSVLQYKILLPLideiksgeGQKKFRSFfYVGDVKQSIYRFRGGKKELFDKVSKDFKQKV 399

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  409 QPLDRNWRSTPAVMKFVNAMgvglFGALYNSLTP--TRDHISCPALEVLIATKSRGvrnasKPQEHIAERIARILTDGdt 486
Cdd:PRK13909   400 DNLDTNYRSAPLIVDFVNEV----FKKKYKNYKTqyAEQHKSGGYVEVVEVADESE-----ELLEQLLQEIQFLLEKG-- 468

                          570       580
                   ....*....|....*....|.
gi 2221774916  487 itdriskasrpARPSDIALLV 507
Cdd:PRK13909   469 -----------IDPDDIAILC 478
HelD_BACSU NF041464
RNA polymerase recycling motor HelD (Bacillota-type);
350-418 1.24e-03

RNA polymerase recycling motor HelD (Bacillota-type);


Pssm-ID: 469352 [Multi-domain]  Cd Length: 772  Bit Score: 42.88  E-value: 1.24e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2221774916  350 VIIDEFQDTNPVQFALLWQLGANATRTLLvGDVKQSIM--GFQGADPRLSQALATANPDATQPLDRNWRST 418
Cdd:NF041464   550 VFIDEAQDYSPFQFAFLKRLFPRSKMTVL-GDLNQAIYahATGPTGFLLLSELFEEEETETIVLTRSYRST 619
 
Name Accession Description Interval E-value
RecB COG1074
3#-5# helicase subunit RecB of the DNA repair enzyme RecBCD (exonuclease V) [Replication, ...
 3-1045 4.80e-100

3#-5# helicase subunit RecB of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair];


Pssm-ID: 440692 [Multi-domain]  Cd Length: 866  Bit Score: 336.16  E-value: 4.80e-100
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916    3 QGLVIVPAGAGAGKTHRIKTQLSDWVKRGVVRPERILAVTFTETAAAELRERIRAGLLADGLVSEAMAVE---------- 72
Cdd:COG1074     18 GGSVLVEASAGSGKTYTLVARYLRLLLERGLDPEEILVVTFTRAAAAEMRERIRERLAEAADLEDPDLEElararrrlar 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916   73 ------RAYVSTIHGLGLRLLTEHALAAGASPQPRHLGDAErDLLIRQSLAhaksldtikaeperfgyeanwqtgntved 146
Cdd:COG1074     98 alenldRAAISTIHSFCQRLLREFAFEAGLDPNFELLDDAE-ALLLEEAVD----------------------------- 147

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  147 slrgrvlsmiDLLRGLGDKGRdrgllAPALSRLDTIYGNvlsdptaaraalgaaiqtmvasfpeggkahitakgNVEKLE 226
Cdd:COG1074    148 ----------DLLREAYAPLD-----ALALARLLDAFGR-----------------------------------DDDSLE 177

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  227 KDLALFKRVHRSPDLLDRDWKLWNDLRGLfvsnrssktpegyddLATAIMAAADVLPAHPGPLADAKLHLSCLISCAQEV 306
Cdd:COG1074    178 ELLLALYKLRSRPDWLEELAELDEALEAL---------------REALLKAKEALAALREALAAAAAPLLAALLRLLAAV 242

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  307 MEAYETRKKALGLIDFADMITGAERLLRTD--PAVLQAVLGEIDCVIIDEFQDTNPVQFALLWQL---GANATRTL-LVG 380
Cdd:COG1074    243 LARYERRKRERGLLDFDDLLHRALRLLRDEdaPWVAERLRERYRHILVDEFQDTSPLQWEILRRLageALADGRTLfLVG 322

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  381 DVKQSIMGFQGADPRL----SQALATANPDATQPLDRNWRSTPAVMKFVNA-----MGVGLFGALYNSLTPTRDHiSCPA 451
Cdd:COG1074    323 DPKQSIYRFRGADPELfleaRRALEGRVDGERLTLTTNFRSTPEVVDAVNAlfaqlMGAGFGEIPYEPVEALRPG-AYPA 401

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  452 LEVLIATKSRGVRNASKPQE--HIAERIARILTDGDTITDRiskaSRPARPSDIALLVCRHTTAARYAEELRARSVPVRI 529
Cdd:COG1074    402 VELWPLEPDDVSEEDAREREarAVAARIRRLLAEGTTVEGG----GRPVRPGDIAVLVRTRSEAAAIARALKAAGIPVAA 477

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  530 SE-DGWATSPVVAaaraalafaanpaDVHSGL--------------LLRT--LGPDPLPLQTATSAQTEGRLGD------ 586
Cdd:COG1074    478 SDrLSLFESPEVR-------------DLLALLrallnpeddlalaaVLRSplFGLSDEDLAALAADRKGESLWEalraye 544

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  587 --DPVLIRLSALSDKMASLPIGAALDLVLSVAGLRLWADCQPNAAASRADLLRLEA---EANEFERAHRDlkaasGFHGe 661
Cdd:COG1074    545 rlARALERLRALRELARRLGLAELLERLLEETGLLERLLALPGGERRLANLLHLDEllqLALEYEQTGGP-----GLAG- 618

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  662 takvFLGWLDARANERDfDRRPDPAANNAEAVEIVTWHASKGREWPITVVAEldngiedwpgstttrfdALDRIDDmavv 741
Cdd:COG1074    619 ----FLRWLERLIEDGG-DEEKRRLESDADAVRIMTIHKSKGLEFPVVFLPA-----------------LRERARA---- 672

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  742 lgsaalvhtpgfaapeatRRFIEDRRedfeanaknLLYVALTRARDRIVLEWPGFLKDREKDapeatnlfhvftdncapq 821
Cdd:COG1074    673 ------------------EELAEELR---------LLYVALTRARDRLVLSGAVKKKDAEKE------------------ 707

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  822 igtnclkiggvncaavikqlpemagftefassvssvpprfgpatplaeiplSPWRlqpsqsrsagevpgtrsiilgapwp 901
Cdd:COG1074    708 ---------------------------------------------------SSWL------------------------- 711

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  902 ttlndAARGTALH-----LALRTYLTRPDLAHGLPSATGLEEATLGMISERATA------LKDWLAAEgytDLATEIPVL 970
Cdd:COG1074    712 -----ARRGTLVHrllehLDFSAPAELRAALARLLARGGLDEEEAEALAEALLAflatplLAELFAAA---EVLREVPFL 783

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  971 G---YTRDGAEIPGIIDLLAMGSNGCLLIDHKSGGSGEGLGP-----YWPQLSSYAGLVPELFPQHPLKGvAVLWVDHGR 1042
Cdd:COG1074    784 LpdlYRGLGGLLKGRIDLVFEDDGRVYIVDYKTNRLGPDDEEylperYRLQLALYALALERLLPGRPVRA-GLYFTDRGR 862


                   ...
gi 2221774916 1043 LEL 1045
Cdd:COG1074    863 LVE 865
UvrD COG0210
Superfamily I DNA or RNA helicase [Replication, recombination and repair];
8-791 3.85e-54

Superfamily I DNA or RNA helicase [Replication, recombination and repair];


Pssm-ID: 439980 [Multi-domain]  Cd Length: 721  Bit Score: 202.09  E-value: 3.85e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916    8 VPAGAGAGKT----HRIKtqlsdW-VKRGVVRPERILAVTFTETAAAELRERIRAGLladglvseAMAVERAYVSTIHGL 82
Cdd:COG0210     24 VLAGAGSGKTrvltHRIA-----YlIAEGGVDPEQILAVTFTNKAAREMRERIEALL--------GRLARGLWVGTFHSL 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916   83 GLRLLTEHALAAGASPQPRHLGDAERDLLIRQSLAHAKsLDTIKAEPERfgyeanwqtgntvedslrgrVLSMIDLlrgl 162
Cdd:COG0210     91 ALRILRRHAELLGLPPNFTILDGDDQLRLIKELLKELG-LDEKRFPPRE--------------------LLSLISR---- 145

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  163 gdkgrdrgllapalsrldtiygnvlsdptaaraalgaaiqtmvasfpeggkahitakgnveklekdlalfkrvhrspdll 242
Cdd:COG0210        --------------------------------------------------------------------------------

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  243 drdWKlwNDLRglfvsnrsskTPEGYDDLAtaimAAADVLPAhpgpladaklhlscliscAQEVMEAYETRKKALGLIDF 322
Cdd:COG0210    146 ---AK--NEGL----------TPEELAELL----AADPEWRA------------------AAELYEAYQERLRANNALDF 188

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  323 ADMITGAERLLRTDPAVLQAVLGEIDCVIIDEFQDTNPVQFALLWQLGANATRTLLVGDVKQSIMGFQGADPRLSQALAT 402
Cdd:COG0210    189 DDLLLLAVRLLEENPEVLEKYQNRFRYILVDEYQDTNPAQYELLRLLAGDGRNLCVVGDDDQSIYGFRGADPENILRFEK 268

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  403 ANPDATQ-PLDRNWRSTPAVMKFVNAMGVGLFGALYNSLTPTRDhiscPALEVLIATksrgVRNASKPQEHIAERIARIL 481
Cdd:COG0210    269 DFPDAKViKLEQNYRSTQNILDAANAVIANNPGRLGKNLWTDNG----EGEKVRLYV----APDEEEEARFVADEIRELH 340

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  482 TDGdtitdriskasrpARPSDIALLVCRHTTAARYAEELRARSVPVRIS------------------------EDG---- 533
Cdd:COG0210    341 EEG-------------VPLSDIAVLYRTNAQSRALEEALRRAGIPYRVVgglrfyeraeikdllaylrllanpDDDvall 407

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  534 -WATSPVVAAARAALAFAANPADVHSGLLLRTLG-PDPLPLQTATSAQTEGRLGDdpvLIRlsALSDKMASLPIGAALDL 611
Cdd:COG0210    408 rILNVPRRGIGAATLERLREAAREEGISLLEALRdLGELAGLSGRAAKALRRFAE---LLE--ALRAAAERLPLEELLEA 482

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  612 VLSVAGLRLW--ADCQPNAAASRADLLRLEAEANEFERAHRDlkaasgfhgETAKVFLGWLDARANERDFDRRPDpaann 689
Cdd:COG0210    483 LLDESGYEEElrEEAGEEAERRLENLEELVDAAARFEERNPG---------ASLEAFLEELALLSDLDAADEDED----- 548

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  690 aeAVEIVTWHASKGREWPITVVAELDNGIedWPGSTttrfdALDRIDDMAvvlgsaalvhtpgfaapeatrrfiEDRRed 769
Cdd:COG0210    549 --AVTLMTLHAAKGLEFPVVFLVGLEEGL--FPHQR-----SLDDEEELE------------------------EERR-- 593

                          810       820
                   ....*....|....*....|..
gi 2221774916  770 feanaknLLYVALTRARDRIVL 791
Cdd:COG0210    594 -------LFYVAITRARERLYL 608
addA_alphas TIGR02784
double-strand break repair helicase AddA, alphaproteobacterial type; AddAB, also called RexAB, ...
 8-1043 8.59e-38

double-strand break repair helicase AddA, alphaproteobacterial type; AddAB, also called RexAB, substitutes for RecBCD in several bacterial lineages. These DNA recombination proteins act before synapse and are particularly important for DNA repair of double-stranded breaks by homologous recombination. The term AddAB is used broadly, with AddA homologous between the alphaproteobacteria (as modeled here) and the Firmicutes, while the partner AddB proteins show no strong homology across the two groups of species. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 274298 [Multi-domain]  Cd Length: 1135  Bit Score: 154.08  E-value: 8.59e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916    8 VPAGAGAGKTHriktQLSDWVKRGV---VRPERILAVTFTETAAAELRERI--RAG----LLADGLVSEAMAVERAY--- 75
Cdd:TIGR02784   15 VSANAGSGKTH----VLTQRVIRLLlagTEPSKILCLTYTKAAAAEMQNRVfkRLGewavLDDADLRARLEALEGKRpda 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916   76 ---------------------VSTIHGLGLRLLTEHALAAGASPQPRHLGDAERDLLI----RQSLAHAKSLDTIKAEPe 130
Cdd:TIGR02784   91 aklaearrlfaraletpgglkIQTIHAFCEALLHQFPLEANVAGHFSVIDDRAAATLLeearRALLAGPAAPDDALADA- 169

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  131 rFGYEANWQTGNTVEDSLRGRVLS---MIDLLRGLGDKGRDRGLLA----PALSRLDTIYGNVLSDPTAARAALGAAIQT 203
Cdd:TIGR02784  170 -LATVLEAAGETGLEALLAEIVARrdaLMAFLDEAGGEGAEARLRRalglAPGDTAEDLLEAVWPLPGLPRLALALIAAL 248

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  204 MvasFPEGGKAHITAKgnveklekdLALFKRVHRSPDLLDRdwklWNDLRGLFV----SNRSSKTP-------------E 266
Cdd:TIGR02784  249 L---KSGGGSKDAAAA---------LSQLREAAAEPDPVAR----LDLLLGAFLtskgEPKSASFVikkaiqkslpdlaE 312

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  267 GYDDLATAIMAAADVLPAhpgpLADAKLHLSCLIsCAQEVMEAYETRKKALGLIDFADMITGAERLLrTDPAVLQAVL-- 344
Cdd:TIGR02784  313 ALEDAASRVEALRERLRA----LRMAQRTLAALR-LAARLLQRYARLKKARGLLDFNDLIERTVALL-ARPGAGAWVHyk 386

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  345 --GEIDCVIIDEFQDTNPVQFALLWQLGAN----------ATRTLL-VGDVKQSIMGFQGADP----RLSQALATANPDA 407
Cdd:TIGR02784  387 ldRGIDHILVDEAQDTSPEQWDIIQALAEEffsgegarsgVERTIFaVGDEKQSIYSFQGADPerfaEERREFSRKVRAV 466

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  408 TQPLDR-----NWRSTPAVMKFVNAM----GVGLFGALYNSLTPTR----DHISCPALEVLIATKSR------------- 461
Cdd:TIGR02784  467 GRKFEDlslnySFRSTPDVLAAVDLVfadpENARGLSADSDAPVHEafrdDLPGRVDLWDLISKEEGeepedwtdpvdel 546

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  462 GVRNAS-KPQEHIAERIARILTDGDTITDRiskaSRPARPSDIALLVcRHTTAARYA--EELRARSVPVRISEDGWATSP 538
Cdd:TIGR02784  547 GERAPEvRLAERIAAEIRAWLDRGTPIPGR----GRAVRPGDILVLV-RKRDAFFSAliRALKRRGIPVAGADRLKLTSH 621

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  539 --VVAAARAALAFAANPADVHSGLLLRT--LGPDPLPLQTATSAQTEGRL---------GDDPVLIRLSALSDKMASLPI 605
Cdd:TIGR02784  622 iaVKDLMALGRFVLQPEDDLSLAALLKSplFGLDEDDLFRLAAGRSGGSLwaalrrreaEFAATLAVLRDWLSLADFLTP 701

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  606 GAALDLVLSVAGLRlwadcqpnaaasRADLLRLEAEA----NEFERAHRDLKaASGFHGETAkvFLGWLDARANE--RDF 679
Cdd:TIGR02784  702 FEFYARLLGRDGGR------------RKLLARLGAEAedilDEFLSQALAYE-RTGLPGLQA--FLSWLEADDPEikREM 766

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  680 DRRPDpaannaeAVEIVTWHASKGREWPITVVAelDNGIEDWPGSTTTRFDALDRIDDMAVVLGSAALVHTPGFAAPeat 759
Cdd:TIGR02784  767 DQARD-------EVRVMTVHGAKGLEAPVVFLV--DTGSKPFASQRAPLLLATGGSGGKAPLWRPASAFDPSLSAAA--- 834

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  760 rrfIEDRREDFEANAKNLLYVALTRARDRIVLewPGFLKDREKDapeaTNLFHVFTDNCAPQIGTNCLKIGGVNCAAVIK 839
Cdd:TIGR02784  835 ---RERLKERAEDEYRRLLYVAMTRAEDRLIV--CGYRGKRESP----KDSWHALVKRALAAAGIAWQEPHPAQGKAEWR 905

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  840 Q------LPEMAGFTEFASSVSSVPPRFGPATPLAEIPLSPWRLQPS-QSRSAGEVPGTRSIILGAPWPTTLNDAARGTA 912
Cdd:TIGR02784  906 LrftrrdWDPVGLPVEAAQTDTLEALPDWLRAPAPAEPALPRPLAPSgLGGAIDSALPGEAVRSSLGTQAPAFALLRGTL 985

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  913 LHLALRtYL------TRPDLAHG-LPSATGLEEATlgmisERATALKDWLAAEGYTDLA--------TEIPVLG-YTRDG 976
Cdd:TIGR02784  986 LHRLLQ-HLpdlppeEREDAARRyLARSAADWPEA-----EREALLAAVLAVLDDPRLApvfapgsrAEVAIMGtLKEGG 1059

                         1130      1140      1150      1160      1170      1180      1190
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2221774916  977 AE--IPGIIDLLAMGSNGCLLIDHKSG----GSGEGLGP-YWPQLSSYAGLVPELFPQHPLKgVAVLWVDHGRL 1043
Cdd:TIGR02784 1060 QQlaVSGQIDRLAVDRDRVLIVDYKTNrpvpATAEEVPPaYLRQLALYRALLRPLYPGRAVE-AALLWTEAPKL 1132
addA_Gpos TIGR02785
helicase-exonuclease AddAB, AddA subunit, Firmicutes type; AddAB, also called RexAB, ...
 6-791 4.13e-33

helicase-exonuclease AddAB, AddA subunit, Firmicutes type; AddAB, also called RexAB, substitutes for RecBCD in several bacterial lineages. These DNA recombination proteins act before synapse and are particularly important for DNA repair of double-stranded breaks by homologous recombination. The term AddAB is used broadly, with AddA homologous between the Firmicutes (as modeled here) and the alphaproteobacteria, while the partner AddB proteins show no strong homology across the two groups of species. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 274299 [Multi-domain]  Cd Length: 1230  Bit Score: 139.07  E-value: 4.13e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916    6 VIVPAGAGAGKTHRIKTQLSDWVKRGVvRPERILAVTFTETAAAELRERIRAGL---LADGLVSEAMA-----VERAYVS 77
Cdd:TIGR02785   17 ILVSASAGSGKTAVLVERIIRKITRGV-DVDRLLVVTFTNAAAREMKERIAEALekeLVQEPNSKHLRrqlalLNTANIS 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916   78 TIHGLGLRLLTEHALAAGASPQPRHLGDAERDLLIRQSLAHAKSLDTIKAEPERFGYEANWQTGNTVEDSLRGRVLSMID 157
Cdd:TIGR02785   96 TLHSFCLKVIRKHYYLLDLDPSFRILTDTEQLLLIKEVLDDVFEEEYYKEDKEAFFELVDNFSGDRSDDGLRDLILQLYD 175

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  158 LLRGLGDkgrdrgllaPA--LSRLDTIYgNVLSDPTAARAALGAAIQTMVASFPEGGKAHI--------TAKGNVEKLEK 227
Cdd:TIGR02785  176 FSRSTPN---------PEkwLNNLAEAY-EVKEKFTIESLKLQQQIKELLKNELEGLQEKLqralelfmAEDGLAPRLEN 245

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  228 ---DLALFKRVHRSPDLLDRdwklWNDLRGL-----FVSNRSSKTPEG-----------YDDLATAIMAAADVLPA---- 284
Cdd:TIGR02785  246 fqlDLQNIDELIQESLAQAD----WNELRKAvaafkFKNLKAAKGDEEdadlleeadklREEAKKQLEKLKTDYFTrsee 321

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  285 -HPGPLADAKLHLSCLISCAQEVMEAYETRKKALGLIDFADMITGAERLLRTDPAVLQAVL----GEIDCVIIDEFQDTN 359
Cdd:TIGR02785  322 dHLRIMQEMKPVVKTLVQLVKDFIERFGAEKREKNILDFSDLEHYALQILTNENESPSEAAefyrEKFHEVLVDEYQDTN 401

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  360 PVQFALLWQL--GANATRTL-LVGDVKQSIMGFQGADPRL----SQALATANPDATQPLD--RNWRSTPAVMKFVN---- 426
Cdd:TIGR02785  402 LVQESILQLVkrGPEEEGNLfMVGDVKQSIYRFRQADPLLflekYHRFAQEGEEHGKRIDlaENFRSRAEVLDTTNflfk 481

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  427 -AMG--VG----------LFGALY--------NSLTPTRDHISCPALEVLIATKSRGVRNASKPQEHIAERIARILTDGD 485
Cdd:TIGR02785  482 qLMDeeVGeidydeeaqlKFGAAKypenpdnkTEELLYEKLLIEEAEEEEIDEEAEILDKAQQEATMVAERIKALIKEGF 561

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  486 TITDRISKASRPARPSDIALLVCRHTTAARYAEELRARSVPVRISE-DGWATSPVVAAARAalafaanpadvhsglLLRT 564
Cdd:TIGR02785  562 KVYDKKTGTYRPVTYRDIVILTRSRGWNLQIMEEFKKYGIPVFANDaENYFQTTEVRVMLS---------------LLRV 626

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  565 LGpDPL---PLQTATSAQTEGRLGDDPVLIRL--------SALSDKMASLPIGAALDLVL-----SVAGLRLWADCQ--- 625
Cdd:TIGR02785  627 ID-NPYqdiPLVAVLRSPIVGFDENELALIRLenkdssyyEAVKDYVKAGLIEDELYEKLntfldSLQKWREFARTHsvs 705

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  626 -------------------PNAAASRADLLRLEAEANEFErahrdlkaASGFHGETAkvFLGWLDaRANERDFD-RRPDP 685
Cdd:TIGR02785  706 eliwkiyndtgyydyvgglPGGKQRQANLYALYERARQYE--------STSFKGLFQ--FIRFIE-RMQERQKDlASAVA 774

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  686 AANNAEAVEIVTWHASKGREWPITVVAELDNgiedwpgstttRFDALDR----IDDMAVVLGSAALVHTPGFAAPEATRR 761
Cdd:TIGR02785  775 VGEAENAVRLMTIHKSKGLEFPVVFVLGMGK-----------QFNKQDLnssyLLDRQLGLGIKYIDPQERLSYPSLPKV 843

                          890       900       910
                   ....*....|....*....|....*....|..
gi 2221774916  762 FIED--RREDFEANAKnLLYVALTRARDRIVL 791
Cdd:TIGR02785  844 AIKQkmKRELLSEEMR-VLYVALTRAKEKLIL 874
UvrD-helicase pfam00580
UvrD/REP helicase N-terminal domain; The Rep family helicases are composed of four structural ...
 3-394 2.85e-31

UvrD/REP helicase N-terminal domain; The Rep family helicases are composed of four structural domains. The Rep family function as dimers. REP helicases catalyze ATP dependent unwinding of double stranded DNA to single stranded DNA. Swiss:P23478, Swiss:P08394 have large insertions near to the carboxy-terminus relative to other members of the family.


Pssm-ID: 395462 [Multi-domain]  Cd Length: 267  Bit Score: 123.89  E-value: 2.85e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916    3 QGLVIVPAGAGAGKT----HRIkTQLsdwVKRGVVRPERILAVTFTETAAAELRERIRAGLLADGLvseamavERAYVST 78
Cdd:pfam00580   13 GGPLLVLAGAGSGKTrvltERI-AYL---ILEGGIDPEEILAVTFTNKAAREMKERILKLLGKAEL-------SELNIST 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916   79 IHGLGLRLLtehalaagaspqprhlgdaerdllirqslahaksldtikaepERFGYEANWQTGNTVEDSLrgrvlsmidl 158
Cdd:pfam00580   82 FHSFCLRIL------------------------------------------RKYANRIGLLPNFSILDEL---------- 109

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  159 lrglgdkgrdrgllapalsrldtiygnvlsdptaaraalgaaiqtmvasfpeggkahitakgNVEKLEKDLALFKRVHRS 238
Cdd:pfam00580  110 --------------------------------------------------------------DQLALLKELLEKDRLNLD 127

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  239 PDLLdrdwklwndlRGLFVSNRSSKTPEGYddlataiMAAADVLPAHPGPLADAklhlscliscAQEVMEAYETRKKALG 318
Cdd:pfam00580  128 PKLL----------RKLELKELISKAKNRL-------LSPEELQQGAADPRDKL----------AAEFYQEYQERLKENN 180

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2221774916  319 LIDFADMITGAERLLRTDPAVLQAVLGEIDCVIIDEFQDTNPVQFALLWQLGANATRTLLVGDVKQSIMGFQGADP 394
Cdd:pfam00580  181 ALDFDDLLLLTLELLRSDPELLEAYRERFKYILVDEFQDTNPIQYRLLKLLAGGHENLFLVGDPDQSIYGFRGADI 256
recB TIGR00609
exodeoxyribonuclease V, beta subunit; The RecBCD holoenzyme is a multifunctional nuclease with ...
 3-794 7.91e-30

exodeoxyribonuclease V, beta subunit; The RecBCD holoenzyme is a multifunctional nuclease with potent ATP-dependent exodeoxyribonuclease activity. Ejection of RecD, as occurs at chi recombinational hotspots, cripples exonuclease activity in favor of recombinagenic helicase activity. All proteins in this family for which functions are known are DNA-DNA helicases that are used as part of an exonuclease-helicase complex (made up of RecBCD homologs) that function to generate substrates for the initiation of recombination and recombinational repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273172 [Multi-domain]  Cd Length: 1087  Bit Score: 128.32  E-value: 7.91e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916    3 QGLVIVPAGAGAGKTHRIKtQLsdwVKR-----GVVRPERILAVTFTETAAAELRERIRAGL----------LADGLVSE 67
Cdd:TIGR00609    9 NGTFLIEASAGTGKTFTIA-QL---YLRlllegGPLTVEEILVVTFTNAATEELKTRIRGRIhqalralkaaLTSQELPE 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916   68 AMAVE---------------------RAYVSTIHGLGLRLLTEHALaagaspqprHLGDAERDLLIrqslahaKSLDTIK 126
Cdd:TIGR00609   85 PLKEAiqdekvkqaitrlrnalatmdEAAIYTIHGFCQRMLEQHAF---------ESDEIFDVELI-------EDESLLL 148

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  127 AEPERFGYEANWqtgntvedslrgrvlsmidllrglgdkgrdrgllapalsrldtiyGNVLSDptaaraalgaaIQTMVA 206
Cdd:TIGR00609  149 AEITKDFWRRNF---------------------------------------------YNLPFD-----------IAQIVL 172

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  207 SfpeggkahitAKGNVEKLEKDLALFKRVHRSPDLLDRDWKLWNdlrglfVSNRSSKTPEGYDDLATAIMAAADVLPAHP 286
Cdd:TIGR00609  173 K----------TKKSPQAVLTQILADLLLQSYLAFPSPPLDLEQ------LIKWHEQIYKDLDKLDHAVFEEIDKLNAER 236

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  287 GPLADAKLHLscLISCAQEVMEAYETRKKALGLIDFADMITGAERLLRT--DPAVLQAVLGEIDCVIIDEFQDTNPVQ-- 362
Cdd:TIGR00609  237 NNLFCLKDRV--FLTLLKEVQEELKKEKKRRREIGFDDLLSRLETALKSaeGEKLAQAIREQYPIALIDEFQDTDPQQyr 314

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  363 -FALLWQlgANATRTL-LVGDVKQSIMGFQGAD-PRLSQALATANPDATqpLDRNWRSTPAVMKFVNAmgvgLFGALYNS 439
Cdd:TIGR00609  315 iFSKLFI--AQKETSLfLIGDPKQAIYSFRGADiFTYLQAKSKADARYT--LGTNWRSTPALVGSLNK----LFSLISNP 386

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  440 LTPTRDHIscPALEVLIATKSRGVRNASKP------------------QEHIAER----IARILTDGDtITDRISKAS-- 495
Cdd:TIGR00609  387 FLEKPIFI--PVLAHQKNSKGSFVINGQEQppihffttevesegvddyRQTIAQKcareIALWLASAA-LGLANFIATfg 463

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  496 -RPARPSDIALLVCRHTTAARYAEELRARSVPVRISEDgwaTSPVvaaaraalafaanpADVHSGLLLRTLgpdplpLQT 574
Cdd:TIGR00609  464 gRPLRAGDIAVLVRGRKEANQIRKALKKAQIPSVYLSD---KSSV--------------FATEEAQELLAL------LEA 520

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  575 ATSAQTEGRLgddpvlirLSALSDKMASLP------IGAALDLVLSVAG-LRLWADC---QPNAAASRADLLRLEAEANE 644
Cdd:TIGR00609  521 LLEPENEGTL--------RAALASSIFGLSaleletLNQDEITWERVVEkFREYHDIwrkIGVLAMFQRLMLEKGIGERL 592

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  645 FERA--HRDL-----------KAASGFHGETAkvFLGWLDAR-----ANERDFDRrpdpAANNAEAVEIVTWHASKGREW 706
Cdd:TIGR00609  593 LSQPggERILtnllhlaellqEAAHQERNKLS--LLRWLEDQisneeEEEEEIIR----LESDAELVKIVTIHKSKGLEY 666

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  707 PITVVAeldnGIEDWPgsTTTRFDALDRIDdmavvlgsaalvHTPGFAAPEATRRFIEDRREDFEANAKNLLYVALTRAR 786
Cdd:TIGR00609  667 PIVFLP----FITDAK--KSNFASLHDQHS------------HEYQLYDFNQSEENQKLARVERLAEDLRLLYVALTRAK 728


                   ....*...
gi 2221774916  787 DRIVLEWP 794
Cdd:TIGR00609  729 KQLFIGIA 736
DEXQc_UvrD cd17932
DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch ...
 320-415 1.29e-21

DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch repair, nucleotide excision repair, and recombinational repair. It plays a critical role in maintaining genomic stability and facilitating DNA lesion repair in many prokaryotic species including Helicobacter pylori and Escherichia coli. UvrD is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350690 [Multi-domain]  Cd Length: 189  Bit Score: 93.73  E-value: 1.29e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  320 IDFADMITGAERLLRTDPAVLQAVLGEIDCVIIDEFQDTNPVQFALLWQLGANATRTLLVGDVKQSIMGFQGADPRLSQA 399
Cdd:cd17932     93 GDFDDLLLYALELLEENPDVREKLQSRFRYILVDEYQDTNPLQYELLKLLAGDGKNLFVVGDDDQSIYGFRGADPENILD 172

                           90
                   ....*....|....*..
gi 2221774916  400 LATANPDATQ-PLDRNW 415
Cdd:cd17932    173 FEKDFPDAKViKLEENY 189
DEXQc_UvrD cd17932
DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch ...
 5-91 6.12e-19

DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch repair, nucleotide excision repair, and recombinational repair. It plays a critical role in maintaining genomic stability and facilitating DNA lesion repair in many prokaryotic species including Helicobacter pylori and Escherichia coli. UvrD is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350690 [Multi-domain]  Cd Length: 189  Bit Score: 85.65  E-value: 6.12e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916    5 LVIvpAGAGAGKT----HRIKtQLsdwVKRGVVRPERILAVTFTETAAAELRERIRAglladgLVSEAMAvERAYVSTIH 80
Cdd:cd17932     16 LVL--AGAGSGKTrvltHRIA-YL---ILEGGVPPERILAVTFTNKAAKEMRERLRK------LLGEQLA-SGVWIGTFH 82

                           90
                   ....*....|.
gi 2221774916   81 GLGLRLLTEHA 91
Cdd:cd17932     83 SFALRILRRYG 93
PRK13909 PRK13909
RecB-like helicase;
10-507 1.68e-14

RecB-like helicase;


Pssm-ID: 237554 [Multi-domain]  Cd Length: 910  Bit Score: 78.47  E-value: 1.68e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916   10 AGAGAGKTHriktQLSdwvkrgvVR----------PERILAVTFTETAAAELRERIRAGLLA---DGLVSEAMAVERAYv 76
Cdd:PRK13909     5 ASAGSGKTF----ALS-------VRflallfkganPSEILALTFTKKAANEMKERIIDTLLNlekEKEESELNELEEKL- 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916   77 stihGLGLRLLTEhalaagaspqprhlgdaERDLLIRQSLAHAKSLDTIKAeperF------------GYEANWQTGNTV 144
Cdd:PRK13909    73 ----GLSKEELLN-----------------KRDKVYQEFLNSELKISTIDA----FfqkilrkfclnlGLSPDFSIKEDT 127

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  145 EDSLRGRVLSMI---DLLRGL------GDKGrdrglLAPALSRLDTIYGNVlsdptaaraalgaaiqtmvASFPEGGKAH 215
Cdd:PRK13909   128 KEELNEKFLSALskeELLELLafikqcESKK-----NNSFFELLEKLYEKN-------------------NELKLFEKAK 183

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  216 ITAKGNVEK-LEKDLALFKRVHRSPDLLDRDWKLWN--DLRGLFVSNRSSKTPEG----YDDLATAIMaaadvlpahpgp 288
Cdd:PRK13909   184 NPIEFDEEKfLEELRSLKQQIQSIETASKNAKKAFKkeDFEELLNSSKTWLEKESeyryFKKLYNEEL------------ 251

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  289 laDAKLHlsCLISCAQEVMEAYETRK-------------------KALGLIDFADMITGAERLL------------RTDp 337
Cdd:PRK13909   252 --DAEFE--ELKNALKRYYDAKENYKlsklfkllqlykeaknelnKKKNALDFDDISKKVYELLgeeeidkdflyfRLD- 326

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  338 avlqavlGEIDCVIIDEFQDTNPVQFALLWQL--------GANATRTL-LVGDVKQSIMGFQGADPRLSQALATANPDAT 408
Cdd:PRK13909   327 -------SKISHILIDEFQDTSVLQYKILLPLideiksgeGQKKFRSFfYVGDVKQSIYRFRGGKKELFDKVSKDFKQKV 399

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  409 QPLDRNWRSTPAVMKFVNAMgvglFGALYNSLTP--TRDHISCPALEVLIATKSRGvrnasKPQEHIAERIARILTDGdt 486
Cdd:PRK13909   400 DNLDTNYRSAPLIVDFVNEV----FKKKYKNYKTqyAEQHKSGGYVEVVEVADESE-----ELLEQLLQEIQFLLEKG-- 468

                          570       580
                   ....*....|....*....|.
gi 2221774916  487 itdriskasrpARPSDIALLV 507
Cdd:PRK13909   469 -----------IDPDDIAILC 478
recB PRK10876
exonuclease V subunit beta; Provisional
 34-526 2.00e-14

exonuclease V subunit beta; Provisional


Pssm-ID: 236784 [Multi-domain]  Cd Length: 1181  Bit Score: 78.47  E-value: 2.00e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916   34 RP---ERILAVTFTETAAAELRERIR--------------------AGLLA--DGLVSEA---MAVER----AYVSTIHG 81
Cdd:PRK10876    53 RPltvEEILVVTFTEAATEELRGRIRsnihelriaclreetdnplyQRLLAeiDDKAQAAqwlLLAERqmdeAAIFTIHG 132

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916   82 LGLRLLTEHALAAGASPQPRHLGDaeRDLLIRQSLA-----HAKSLDTIKAEperfgyeANWQTGNTVEDSLRgrvlsmi 156
Cdd:PRK10876   133 FCQRMLNLNAFESGMLFEQQLIED--ESLLRYQACAdfwrrHCYPLPREIAR-------VVFQEWKGPEALLK------- 196

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  157 DLLRGL-GDkgrdrgllAPalsrldtiygnVLSDPTAARAALGAAIQTMVASFPEGGKAHITAKGNVEKLEKDLALFKRV 235
Cdd:PRK10876   197 DISRYLqGE--------AP-----------VIKAPPPDDETLASRHEQIVARIDAVKQQWREAVGELDALIESSGVDRRS 257

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  236 HRS---PDLLD----------RDWKLWNDL-----RGLFVSNRSSKTPEgyddlaTAIMAAADVLPAHPGPLADaklhls 297
Cdd:PRK10876   258 YNSknlPKWLEkisawaeeetNSYQLPKELekfsqRFLLEKTKKGETPQ------HPLFEAIDQLLAEPLSLRD------ 325

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  298 CLISCA-QEVMEAYETRKKALGLIDFADMITGAERLLRTD--PAVLQAVLGEIDCVIIDEFQDTNPVQ---FALLWqLGA 371
Cdd:PRK10876   326 LVITRAlAEIRETVAQEKRRRGELGFDDLLSRLDSALQSEggEALAAAIRTRYPVAMIDEFQDTDPQQyriFRRIY-RHQ 404

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  372 NATRTLLVGDVKQSIMGFQGADPrLSQALATANPDATQPLDRNWRSTPAVMKFVNAmgvgLFgalynSLTPTR---DHIs 448
Cdd:PRK10876   405 PETALLLIGDPKQAIYAFRGADI-FTYMKARSEVSAHYTLDTNWRSAPGMVNSVNK----LF-----SQTDDPflfREI- 473

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  449 cPALEVLIATKSRGVR--NASKPQ-----------------------EHIAERIARILTDGDTITDRISKA--SRPARPS 501
Cdd:PRK10876   474 -PFIPVKAAGKNQALRfvVKGETQpamkfwlmegegvgvgdyqqtmaQQCAAQIRDWLQAGQRGEALLMNGddSRPVRAS 552

                          570       580
                   ....*....|....*....|....*
gi 2221774916  502 DIALLVCRHTTAARYAEELRARSVP 526
Cdd:PRK10876   553 DITVLVRSRQEAALIRDALTLLAIP 577
uvrD PRK11773
DNA-dependent helicase II; Provisional
 3-427 3.17e-13

DNA-dependent helicase II; Provisional


Pssm-ID: 236976 [Multi-domain]  Cd Length: 721  Bit Score: 74.14  E-value: 3.17e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916    3 QGLVIVPAGAGAGKT----HRIKtqlsdW---VKRgvVRPERILAVTFTETAAAELRERIRAGLladGLVSEAMaveraY 75
Cdd:PRK11773    22 LGNMLVLAGAGSGKTrvlvHRIA-----WlmqVEN--ASPYSIMAVTFTNKAAAEMRHRIEQLL---GTSQGGM-----W 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916   76 VSTIHGLGLRLLTEHALAAGAsPQprhlgdaerDLLIrqslahaksLDTikaeperfgyeanwqtgntvEDSLRgrvlsm 155
Cdd:PRK11773    87 VGTFHGLAHRLLRAHWQDANL-PQ---------DFQI---------LDS--------------------DDQLR------ 121

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  156 idllrglgdkgrdrgllapalsrldtiygnvlsdptaaraalgaaiqtmvasfpeggkahitakgnveklekdlaLFKRV 235
Cdd:PRK11773   122 ---------------------------------------------------------------------------LLKRL 126

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  236 HRSPDLLDRDWK----LWndlrglFVSNrssKTPEGyddlataimaaadVLPAHPGPLADakLHLSCLIscaqEVMEAYE 311
Cdd:PRK11773   127 IKALNLDEKQWPprqaQW------YING---QKDEG-------------LRPQHIQSYGD--PVEQTWL----KIYQAYQ 178

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  312 TRKKALGLIDFADMITGAERLLRTDPAVLQAVLGEIDCVIIDEFQDTNPVQFALLWQLGANATRTLLVGDVKQSIMGFQG 391
Cdd:PRK11773   179 EACDRAGLVDFAELLLRAHELWLNKPHILQHYQERFTHILVDEFQDTNAIQYAWIRLLAGDTGKVMIVGDDDQSIYGWRG 258

                          410       420       430
                   ....*....|....*....|....*....|....*..
gi 2221774916  392 ADPRLSQALATANPDA-TQPLDRNWRSTPAVMKFVNA 427
Cdd:PRK11773   259 AQVENIQRFLNDFPGAeTIRLEQNYRSTANILKAANA 295
PRK10919 PRK10919
ATP-dependent DNA helicase Rep; Provisional
 310-426 1.35e-11

ATP-dependent DNA helicase Rep; Provisional


Pssm-ID: 182838 [Multi-domain]  Cd Length: 672  Bit Score: 68.71  E-value: 1.35e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  310 YETRKKALGLIDFADMITGAERLLRTDPAVLQAVLGEIDCVIIDEFQDTNPVQFALLWQLGANATRTLLVGDVKQSIMGF 389
Cdd:PRK10919   171 YDAHLKACNVLDFDDLILLPTLLLQRNEEVRERWQNKIRYLLVDEYQDTNTSQYELVKLLVGSRARFTVVGDDDQSIYSW 250

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 2221774916  390 QGADPrlsQALATANPDATQ----PLDRNWRSTPAVMKFVN 426
Cdd:PRK10919   251 RGARP---QNLVLLSQDFPAlqviKLEQNYRSSGRILKAAN 288
SF1_C_UvrD cd18807
C-terminal helicase domain of UvrD family helicases; UvrD is a highly conserved helicase ...
 693-791 6.62e-07

C-terminal helicase domain of UvrD family helicases; UvrD is a highly conserved helicase involved in mismatch repair, nucleotide excision repair, and recombinational repair. It plays a critical role in maintaining genomic stability and facilitating DNA lesion repair in many prokaryotic species including Helicobacter pylori and Escherichia coli. This family also includes ATP-dependent helicase/nuclease AddA and helicase/nuclease RecBCD subunit RecB, among others. UvrD family helicases are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350194 [Multi-domain]  Cd Length: 150  Bit Score: 49.92  E-value: 6.62e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  693 VEIVTWHASKGREWPITVVAELDNGIedWPGSTTTRFDALDRiDDMAvvlgsaalvhtpgfaapeatrrfiEDRRedfea 772
Cdd:cd18807     86 VTLMTIHASKGLEFPVVFIVGLGEGF--IPSDASYHAAKEDE-ERLE------------------------EERR----- 133

                           90
                   ....*....|....*....
gi 2221774916  773 naknLLYVALTRARDRIVL 791
Cdd:cd18807    134 ----LLYVALTRAKKELYL 148
AAA_19 pfam13245
AAA domain;
4-96 2.04e-06

AAA domain;


Pssm-ID: 433059 [Multi-domain]  Cd Length: 136  Bit Score: 48.37  E-value: 2.04e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916    4 GLVIVPAGAGAGKTHRIKTQLSDWVKRGVVrPERILAVTFTETAAAELRERIraGLLAdglvseamaverayvSTIHglg 83
Cdd:pfam13245   12 KVVLLTGGPGTGKTTTIRHIVALLVALGGV-SFPILLAAPTGRAAKRLSERT--GLPA---------------STIH--- 70

                           90
                   ....*....|...
gi 2221774916   84 lRLLTEHALAAGA 96
Cdd:pfam13245   71 -RLLGFDDLEAGG 82
HelD COG3973
DNA helicase IV [Replication, recombination and repair];
350-485 2.27e-06

DNA helicase IV [Replication, recombination and repair];


Pssm-ID: 443173 [Multi-domain]  Cd Length: 699  Bit Score: 51.79  E-value: 2.27e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  350 VIIDEFQDTNPVQFALLWQLGANATRTLlVGDVKQSIMGFQGADPrLSQALATANPDATQ--PLDRNWRSTPAVM----K 423
Cdd:COG3973    473 VVVDEAQDLSPMQWRVLKRRFPSASFTI-VGDLAQAIHPYRGAES-WEEVLEPLGGDRARlvELTKSYRSTAEIMefanR 550

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2221774916  424 FVNAMGVGLfgalyNSLTPTRDH------ISCPALEVLIATksrgvrnaskpqehIAERIARILTDGD 485
Cdd:COG3973    551 VLRAAGPDL-----PPPESVRRHgepprvVRVPSEAELAAA--------------VVEAVRELLAEGE 599
helD PRK11054
DNA helicase IV; Provisional
 6-87 8.65e-06

DNA helicase IV; Provisional


Pssm-ID: 182930 [Multi-domain]  Cd Length: 684  Bit Score: 49.95  E-value: 8.65e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916    6 VIVPAGAGAGKTHRIKTQLSDWVKRGVVRPERILAVTFTETAAAELRERIRaglladglvsEAMAVERAYVSTIHGLGLR 85
Cdd:PRK11054   212 LLVLAGAGSGKTSVLVARAGWLLARGQAQPEQILLLAFGRQAAEEMDERIR----------ERLGTEDITARTFHALALH 281


                   ..
gi 2221774916   86 LL 87
Cdd:PRK11054   282 II 283
PDDEXK_1 pfam12705
PD-(D/E)XK nuclease superfamily; Members of this family belong to the PD-(D/E)XK nuclease ...
 895-1037 5.97e-04

PD-(D/E)XK nuclease superfamily; Members of this family belong to the PD-(D/E)XK nuclease superfamily


Pssm-ID: 432731 [Multi-domain]  Cd Length: 250  Bit Score: 42.91  E-value: 5.97e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  895 ILGAPWPTTLNDAARGTALHLALRTYLTRPDL-----------------------AHGLPSATGLEEATLGMISERATAL 951
Cdd:pfam12705   22 LLGLREDEELDAPDLGTLVHAALERFYRWGRLpeedleellqalleelwpelglqSEILPRLPWLAGRLRRRLERMLRRL 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  952 KDWLAAE-GYTDLATEIPVLGYTrdgAEIPGIIDLL-AMGSNGCLLIDHKSGG----SGEGLGPYWPQLSSYAGLVPELF 1025
Cdd:pfam12705  102 AEWLRARrGFRPVAVELGFGGTT---VRLVGRIDRVdLDGEGYLRIIDYKTGSappqSEDLDLYEGLQLLLYLLALAAGE 178

                          170
                   ....*....|..
gi 2221774916 1026 PQHPLKGVAVLW 1037
Cdd:pfam12705  179 KALGGPAGALYL 190
AAA_19 pfam13245
AAA domain;
318-389 6.08e-04

AAA domain;


Pssm-ID: 433059 [Multi-domain]  Cd Length: 136  Bit Score: 41.05  E-value: 6.08e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2221774916  318 GLIDFADMITGAERLLRTDPAvlqavlgEIDCVIIDEFQDTN-PVQFALLWQLgANATRTLLVGDVKQSIMGF 389
Cdd:pfam13245   71 RLLGFDDLEAGGFLRDEEEPL-------DGDLLIVDEFSMVDlPLAYRLLKAL-PDGAQLLLVGDPDQLPSVG 135
HelD_BACSU NF041464
RNA polymerase recycling motor HelD (Bacillota-type);
350-418 1.24e-03

RNA polymerase recycling motor HelD (Bacillota-type);


Pssm-ID: 469352 [Multi-domain]  Cd Length: 772  Bit Score: 42.88  E-value: 1.24e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2221774916  350 VIIDEFQDTNPVQFALLWQLGANATRTLLvGDVKQSIM--GFQGADPRLSQALATANPDATQPLDRNWRST 418
Cdd:NF041464   550 VFIDEAQDYSPFQFAFLKRLFPRSKMTVL-GDLNQAIYahATGPTGFLLLSELFEEEETETIVLTRSYRST 619
DExxQc_SF1-N cd17914
DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members ...
 344-394 2.15e-03

DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members include UvrD/Rep, Pif1-like, and Upf-1-like proteins. Like SF2, they do not form toroidal, predominantly hexameric structures like SF3-6. Their helicase core is surrounded by C and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains or domains engaged in protein-protein interactions. SF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438706 [Multi-domain]  Cd Length: 121  Bit Score: 39.01  E-value: 2.15e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2221774916  344 LGEIDCVIIDEFQDTNPVQFALLWQLGANATRTLLVGDVKQSIMGFQGADP 394
Cdd:cd17914     44 AAQLDNILVDEAAQILEPETSRLIDLALDQGRVILVGDHDQLGPVWRGAVL 94
helD PRK11054
DNA helicase IV; Provisional
 693-789 3.04e-03

DNA helicase IV; Provisional


Pssm-ID: 182930 [Multi-domain]  Cd Length: 684  Bit Score: 41.47  E-value: 3.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  693 VEIVTWHASKGREWPITVVAELDNGIEDWPgstttrfdALDRiddmAVVLGSAALVHTPGFaaPEAtrrfiEDRRedfea 772
Cdd:PRK11054   589 IDFMTIHASKGQQADYVIILGLQEGQDGFP--------APAR----ESIMEEALLPPPEDF--PDA-----EERR----- 644

                           90
                   ....*....|....*..
gi 2221774916  773 naknLLYVALTRARDRI 789
Cdd:PRK11054   645 ----LLYVALTRAKHRV 657
DNA2 COG1112
Superfamily I DNA and/or RNA helicase [Replication, recombination and repair];
1-481 6.39e-03

Superfamily I DNA and/or RNA helicase [Replication, recombination and repair];


Pssm-ID: 440729 [Multi-domain]  Cd Length: 819  Bit Score: 40.50  E-value: 6.39e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916    1 MDQGLVIVPAGAGAGKTHRIKTQLSDWVKRGVVRPERILAVTFTETAAAELRERIRAGLLADGLVSEAMAVERAYVSTIH 80
Cdd:COG1112    212 LLALLLLLALLLLLDALLLLLAALALLALALLLALLLLLLALLLLAALALLRAALRLDLLAALELLAALSLALLALLAAL 291

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916   81 GLGLRLLTEHALAAGASPQPRHLGDAERDLLIRQSLAHAKSLDTIKAEPERFGYEANWQTGNTVEDSLRGRVLSMIDLLR 160
Cdd:COG1112    292 ALALLLLAALALLLALALAALLALLALLALLAARLAAALAALLLLLLLEELALLAALLLLLELALLRLLAALLLALALLL 371

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  161 GLGDkgRDRGLLAPALSRLDTIYGNVLSDPTAARAALGAAIQTMVASFPEGGKAHITAKGNVEKLEKDLALFKRVHRSPD 240
Cdd:COG1112    372 LLAL--EELLLLALLRLLAEGLALLLLLLLAALLRLARALLLLALLLAAAAAALAALLLLALALLAALLALLLLLAAALA 449

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  241 LLDRDWKLWNDLRGLFVSNRSSKTPEGYDDLATAIMAAadVLPAHPGPLADAKLHLSCLISCAQEVMEAYETRKKALGLI 320
Cdd:COG1112    450 ALLALLLLLLLALAALLLLLAAAAALLALALLESLLEE--LIEEHPEELEKLIAELREAARLRRALRRELKKRRELRKLL 527

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  321 dfadmitgAERLLRTDPAV----------LQAVLGEIDCVIIDE-FQdtnpVQFALLWQLGANATRTLLVGDVKQ----- 384
Cdd:COG1112    528 --------WDALLELAPVVgmtpasvarlLPLGEGSFDLVIIDEaSQ----ATLAEALGALARAKRVVLVGDPKQlppvv 595

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  385 -----SIMGFQGADPRLSQALATANPDATQPLDRNWRSTPAVMKFVNAmgvgLF--GALYNSLTPTRDHISCPALEV-LI 456
Cdd:COG1112    596 fgeeaEEVAEEGLDESLLDRLLARLPERGVMLREHYRMHPEIIAFSNR----LFydGKLVPLPSPKARRLADPDSPLvFI 671

                          490       500
                   ....*....|....*....|....*...
gi 2221774916  457 ATKSRGVRNASK---PQEhiAERIARIL 481
Cdd:COG1112    672 DVDGVYERRGGSrtnPEE--AEAVVELV 697
Slr0479 COG2887
RecB family exonuclease [Replication, recombination and repair];
895-1038 7.57e-03

RecB family exonuclease [Replication, recombination and repair];


Pssm-ID: 442133 [Multi-domain]  Cd Length: 248  Bit Score: 39.25  E-value: 7.57e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  895 ILG-APWPTTLNDAA-RGTALHLALRTYLTRPdlAHGLPSATGLEE-----ATLGMIS--------ERATALKDWLAA-- 957
Cdd:COG2887     23 ILGlRDPLEPPPDAAdRGTLVHAVLERFYKLP--ADELPAEELLALleeawAELGFEDpwaaalwlERAERLLEAFLEwe 100

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221774916  958 ---EGYTDLATEIPVLGYTRDGAEIPGIIDLLAMGSNGCL-LIDHKSGG--SGEGLGPYWPQLSSYAGLVPELFPQHPLK 1031
Cdd:COG2887    101 rapAGLEPVAVEVEFELELPGGVRLRGRIDRIDRLPDGRLvVVDYKTGKapSTKDEAGEDPQLALYALALERGFEGLVPA 180


                   ....*..
gi 2221774916 1032 GVAVLWV 1038
Cdd:COG2887    181 GARLVYL 187
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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