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Conserved domains on  [gi|2221775887|ref|WP_244400604|]
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nitroreductase family protein [Porphyromonas somerae]

Protein Classification

nitroreductase family protein( domain architecture ID 10002498)

nitroreductase family protein may catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor

CATH:  3.40.109.10|2.20.180.10
EC:  1.-.-.-
Gene Ontology:  GO:0016491
PubMed:  29078300|7601851
SCOP:  3001947

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NfnB COG0778
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway ...
 167-335 2.56e-25

Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway/BioSystem: Pyrimidine degradation


:

Pssm-ID: 440541 [Multi-domain]  Cd Length: 163  Bit Score: 99.54  E-value: 2.56e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221775887 167 FFDFAKSRSSVREFSEALVPHDVLEDVINLANTAPSVCNRQGVSVVIVEDKDKIQQILDI--QKGLAGYTSISQLAVIKS 244
Cdd:COG0778     1 LLELLLTRRSVRKFTDKPVSDEELEELLEAARLAPSAGNLQPWRFVVVRDPELRERLAEAlaEANQEWVADAPVLIVVCA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221775887 245 NRSYFYSIGERNQLyIDGGIYLMNLLYAFHYYGIAACtahW-GLLNDAdsKMEDLLGLSPAEQVICIVSFGYPKETVRST 323
Cdd:COG0778    81 DPDRSEKVPERYAL-LDAGIAAQNLLLAARALGLGTC---WiGGFDPE--KVRELLGLPEGEEPVALLALGYPAEELNPR 154

                         170
                  ....*....|..
gi 2221775887 324 lslRRKANENLT 335
Cdd:COG0778   155 ---PRKPLEEVV 163
 
Name Accession Description Interval E-value
NfnB COG0778
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway ...
 167-335 2.56e-25

Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440541 [Multi-domain]  Cd Length: 163  Bit Score: 99.54  E-value: 2.56e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221775887 167 FFDFAKSRSSVREFSEALVPHDVLEDVINLANTAPSVCNRQGVSVVIVEDKDKIQQILDI--QKGLAGYTSISQLAVIKS 244
Cdd:COG0778     1 LLELLLTRRSVRKFTDKPVSDEELEELLEAARLAPSAGNLQPWRFVVVRDPELRERLAEAlaEANQEWVADAPVLIVVCA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221775887 245 NRSYFYSIGERNQLyIDGGIYLMNLLYAFHYYGIAACtahW-GLLNDAdsKMEDLLGLSPAEQVICIVSFGYPKETVRST 323
Cdd:COG0778    81 DPDRSEKVPERYAL-LDAGIAAQNLLLAARALGLGTC---WiGGFDPE--KVRELLGLPEGEEPVALLALGYPAEELNPR 154

                         170
                  ....*....|..
gi 2221775887 324 lslRRKANENLT 335
Cdd:COG0778   155 ---PRKPLEEVV 163
Nitro_FMN_reductase cd02062
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
 172-315 3.49e-24

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380311 [Multi-domain]  Cd Length: 139  Bit Score: 95.83  E-value: 3.49e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221775887 172 KSRSSVREFSEALVPHDVLEDVINLANTAPSVCNRQGVSVVIVEDKDKIQQILDIQKGLAGYTSISQLAVI---KSNRSY 248
Cdd:cd02062     2 KTRRSIRKFTDKPVPEEKLRKILEAARLAPSAGNLQPWRFIVVRDREKKEKLAKLAAPNQKFIAGAPVVIVvvaDPDKSR 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2221775887 249 FYSIgernqlyIDGGIYLMNLLYAFHYYGIAACTAHWGllNDADSKMEDLLGLSPAEQVICIVSFGY 315
Cdd:cd02062    82 PWAL-------EDAGAAAQNLLLAAAALGLGSCWIGGF--DFREDKVRELLGIPENLRPVALIAIGY 139
Nitroreductase pfam00881
Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent ...
 171-315 6.27e-20

Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds.


Pssm-ID: 425926 [Multi-domain]  Cd Length: 168  Bit Score: 85.52  E-value: 6.27e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221775887 171 AKSRSSVREFSEALVPHDVLEDVINLANTAPSVCNRQGVSVVIVEDKDKIQQILDI------------------------ 226
Cdd:pfam00881   1 IRQRRSVRKFDPEPVPKEVLEEILEAARRAPSAGNLQPWRFYVVTDGELRYRLAEAalelllvepaaalllllrrdanlk 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221775887 227 ---QKGLAGYTSISQLAVIKSNRSYFYSIGERNQLYIDGGIYLMNLLYAFHYYGIAACTAHWGLlndaDSKMEDLLGLSP 303
Cdd:pfam00881  81 lllQDFLRGAPVLIVITASLSTYLRKAAERAYREALLDAGAAAQNLLLAATSLGLGSCPIGGFD----AAAVRELLGLPD 156

                         170
                  ....*....|..
gi 2221775887 304 AEQVICIVSFGY 315
Cdd:pfam00881 157 DERLVGLIAVGY 168
 
Name Accession Description Interval E-value
NfnB COG0778
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway ...
 167-335 2.56e-25

Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440541 [Multi-domain]  Cd Length: 163  Bit Score: 99.54  E-value: 2.56e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221775887 167 FFDFAKSRSSVREFSEALVPHDVLEDVINLANTAPSVCNRQGVSVVIVEDKDKIQQILDI--QKGLAGYTSISQLAVIKS 244
Cdd:COG0778     1 LLELLLTRRSVRKFTDKPVSDEELEELLEAARLAPSAGNLQPWRFVVVRDPELRERLAEAlaEANQEWVADAPVLIVVCA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221775887 245 NRSYFYSIGERNQLyIDGGIYLMNLLYAFHYYGIAACtahW-GLLNDAdsKMEDLLGLSPAEQVICIVSFGYPKETVRST 323
Cdd:COG0778    81 DPDRSEKVPERYAL-LDAGIAAQNLLLAARALGLGTC---WiGGFDPE--KVRELLGLPEGEEPVALLALGYPAEELNPR 154

                         170
                  ....*....|..
gi 2221775887 324 lslRRKANENLT 335
Cdd:COG0778   155 ---PRKPLEEVV 163
Nitro_FMN_reductase cd02062
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
 172-315 3.49e-24

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380311 [Multi-domain]  Cd Length: 139  Bit Score: 95.83  E-value: 3.49e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221775887 172 KSRSSVREFSEALVPHDVLEDVINLANTAPSVCNRQGVSVVIVEDKDKIQQILDIQKGLAGYTSISQLAVI---KSNRSY 248
Cdd:cd02062     2 KTRRSIRKFTDKPVPEEKLRKILEAARLAPSAGNLQPWRFIVVRDREKKEKLAKLAAPNQKFIAGAPVVIVvvaDPDKSR 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2221775887 249 FYSIgernqlyIDGGIYLMNLLYAFHYYGIAACTAHWGllNDADSKMEDLLGLSPAEQVICIVSFGY 315
Cdd:cd02062    82 PWAL-------EDAGAAAQNLLLAAAALGLGSCWIGGF--DFREDKVRELLGIPENLRPVALIAIGY 139
PnbA_NfnB-like cd02136
nitroreductase similar to Mycobacterium smegmatis NfnB; Members of this family utilize FMN as ...
 172-319 4.92e-20

nitroreductase similar to Mycobacterium smegmatis NfnB; Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source of reducing equivalents in an obligatory two-election transfer mechanism. The enzyme is typically a homodimer. Mycobacterium smegmatis nitroreductase NfnB plays a role in resistance to benzothiazinone.


Pssm-ID: 380313 [Multi-domain]  Cd Length: 152  Bit Score: 84.95  E-value: 4.92e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221775887 172 KSRSSVREFSEALVPHDVLEDVINLANTAPSVCNRQGVSVVIVEDK--DKIQQildiqkglAGYTSISQLAVIKSNRSYF 249
Cdd:cd02136     3 KSRRSVRAFKDKPVPKETIEKILEAARRAPSGKNTQPWRVYVVTGKarERLKK--------AFFGAPVALFLTMDKVLGP 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221775887 250 YSIgernqlyIDGGIYLMNLLYAFHYYGIAACTAHwGLLNDADsKMEDLLGLSPAEQVICIVSFGYPKET 319
Cdd:cd02136    75 WSW-------FDLGAFLQNLMLAAHALGLGTCPQG-ALAGYPD-VVRKELGIPDDEELVCGIALGYPDPD 135
Nitroreductase pfam00881
Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent ...
 171-315 6.27e-20

Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds.


Pssm-ID: 425926 [Multi-domain]  Cd Length: 168  Bit Score: 85.52  E-value: 6.27e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221775887 171 AKSRSSVREFSEALVPHDVLEDVINLANTAPSVCNRQGVSVVIVEDKDKIQQILDI------------------------ 226
Cdd:pfam00881   1 IRQRRSVRKFDPEPVPKEVLEEILEAARRAPSAGNLQPWRFYVVTDGELRYRLAEAalelllvepaaalllllrrdanlk 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221775887 227 ---QKGLAGYTSISQLAVIKSNRSYFYSIGERNQLYIDGGIYLMNLLYAFHYYGIAACTAHWGLlndaDSKMEDLLGLSP 303
Cdd:pfam00881  81 lllQDFLRGAPVLIVITASLSTYLRKAAERAYREALLDAGAAAQNLLLAATSLGLGSCPIGGFD----AAAVRELLGLPD 156

                         170
                  ....*....|..
gi 2221775887 304 AEQVICIVSFGY 315
Cdd:pfam00881 157 DERLVGLIAVGY 168
nitroreductase cd02151
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 169-319 3.70e-14

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers..


Pssm-ID: 380326 [Multi-domain]  Cd Length: 157  Bit Score: 69.10  E-value: 3.70e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221775887 169 DFAKSRSSVREFSEALVPHDVLEDVINLANTAPSVCNRQGVSVVIVEDKDKIQQILDIQKGLAGYTSISQLAVIksnrsy 248
Cdd:cd02151     1 ELLKKRRSIRKYTDEPIEEEKLEEILEAALLAPSSRNSRPVEFIVVDDKETLKKLSECKPHGSAFLKGAPAAIV------ 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2221775887 249 fySIG--ERNQLYI-DGGIYLMNLLYAFHYYGIAACTAHWGLLNDADSK-----MEDLLGLSPAEQVICIVSFGYPKET 319
Cdd:cd02151    75 --VLAdtEKSDTWIeDASIAATYIQLAAESLGLGSCWIQIRNRETQDGKtaeeyVRELLGIPENYRVLCIIALGYPDEE 151
nitroreductase cd20608
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
 168-315 1.34e-12

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380329 [Multi-domain]  Cd Length: 145  Bit Score: 64.28  E-value: 1.34e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221775887 168 FDFAKSRSSVREFSEALVPHDVLEDVINLANTAPSVCNRQGVSVVIVEDKDKIQQildiqkgLAGYTSISQLAV------ 241
Cdd:cd20608     1 FEAIKTRRSVRRFSDKPVEEEKLEKILEAARLAPSWANKQCWRFIVVTDKETLSE-------LAKKESPSNGWLkdapvi 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221775887 242 ----IKSNRSyfysiGERNQL--YI-DGGIYLMNLLYAFHYYGIAACtahWGLLNDaDSKMEDLLGLSPAEQVICIVSFG 314
Cdd:cd20608    74 ivvcADPKDS-----GWLNGQnyYLvDAAIAMQNLMLAATDLGLGTC---WIGAFD-EKKVKEILGIPENIRVVALTPLG 144


                  .
gi 2221775887 315 Y 315
Cdd:cd20608   145 Y 145
nitroreductase cd02139
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 167-318 5.44e-12

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380316 [Multi-domain]  Cd Length: 165  Bit Score: 63.26  E-value: 5.44e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221775887 167 FFDFAKSRSSVREFSEALVPHDVLEDVINLANTAPSVCNRQGVSVVIVEDKDKIQQILdiqKGLAGYTSISQ---LAVIK 243
Cdd:cd02139     1 VYEAIKKRRSIRKYKPTPVEEEKLLRILEAARLAPSAKNRQPWRFIVVKDKELKEKLA---EAANGQKFIAEapvVIVAC 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2221775887 244 SNRSyfYSIGERNQLY--IDGGIYLMNLLYAFHYYGIAACtahW-GLLNDAdsKMEDLLGLSPAEQVICIVSFGYPKE 318
Cdd:cd02139    78 ADPS--ESGMGCGKPYylVDVAIAMEHLVLAATEEGLGTC---WiGAFDED--KVKEILGIPEEYRVVALTPLGYPAE 148
nitroreductase cd20609
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 166-315 1.14e-11

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers.


Pssm-ID: 380330 [Multi-domain]  Cd Length: 145  Bit Score: 61.64  E-value: 1.14e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221775887 166 SFFDFAKSRSSVREFSEALVPHDVLEDVINLANTAPSVCNRQGVSVVIVEDKDKIQQILDIQKGLAGytsiSQLAVI--- 242
Cdd:cd20609     1 DFLELAKKRYSVRKFSDKPVEKEKLDKILEAGRLAPTAVNYQPQRILVVRSEEALEKLAKATPRFFG----APLVIVvcy 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2221775887 243 KSNRSYFYSIGERNQLYIDGGIYLMNLLYAFHYYGIAACtahWGLLNDADsKMEDLLGLSPAEQVICIVSFGY 315
Cdd:cd20609    77 DKDESWKRPYDGKDSGDIDAAIVATHMMLAATELGLGTC---WVGNFDPE-KVREAFNLPENLEPVAILPLGY 145
nitroreductase_FeS-like cd02143
nitroreductases with an N-terminal iron-sulfur cluster-binding domain; Members of this family ...
 170-317 1.16e-11

nitroreductases with an N-terminal iron-sulfur cluster-binding domain; Members of this family utilize FMN as a cofactor. This family may be involved in the reduction of flavin or nitroaromatic compounds via an obligatory two-electron transfer. Nitroreductase is homodimer. Each subunit contains one FMN molecule.


Pssm-ID: 380319 [Multi-domain]  Cd Length: 187  Bit Score: 62.88  E-value: 1.16e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221775887 170 FAKSRSSVREFSEALVPHDVLEDVINLANTAPSVCNRQGVSVVIVEDKDKIQQILD---------IQKGLAGYTSISQLA 240
Cdd:cd02143     1 LLRSRRSIRRYKDKPVPRETLEKLLDIARYAPTGHNSQPVHWLVVDDPEKVRRLAElvidwmrelIKEDPELAGKLFLDG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221775887 241 VIKSNRSyfysiGE----RN--QL------------YIDGGIYLMNL-LYAfHYYGIAACtahW-GLLN---DADSKMED 297
Cdd:cd02143    81 IVAAWEK-----GIdvilRGapHLvvahapkdaptpPVDCAIALTYLeLAA-PSLGLGTC---WaGFFTaaaNNYPPLRE 151

                         170       180
                  ....*....|....*....|
gi 2221775887 298 LLGLSPAEQVICIVSFGYPK 317
Cdd:cd02143   152 ALGLPEGHKVGGAMMLGYPK 171
MhqN-like cd02137
nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily ...
 168-318 3.00e-11

nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily of the nitroreductase family containing uncharacterized proteins; includes nitroreductases MhqN, YodC, YdgI, DrgA. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380314 [Multi-domain]  Cd Length: 147  Bit Score: 60.72  E-value: 3.00e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221775887 168 FDFAKSRSSVREF-SEALVPHDVLEDVINLANTAPSVCNRQGVSVVIVEDKDKIQQILDIQKGLAGYTSISQLAVIKSNr 246
Cdd:cd02137     1 LEVIKSRRSVRNFdPDHKIPKEELKEILELATLAPSSFNLQPWRFVVVRDPELKAKLAEAAYNQPQVTTASAVILVLGD- 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2221775887 247 syfysigernqlyIDGGIYLMNLLYAFHYYGIAACTahwglLNDAD-SKMEDLLGLSPAEQVICIVSFGYPKE 318
Cdd:cd02137    80 -------------LNAGLAAMNLMLAAKAKGYDTCP-----MGGFDkEKVAELLNLPDRYVPVLLIAIGKAAD 134
nitroreductase cd02150
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 172-318 6.14e-11

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers.


Pssm-ID: 380325 [Multi-domain]  Cd Length: 156  Bit Score: 59.92  E-value: 6.14e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221775887 172 KSRSSVREFSEALVPHDVLEDVINLANTAPSVCNRQGVSVVIVEDKDKIQQILDIQKGlAGYTSISQLAVI------KSN 245
Cdd:cd02150     2 LTRRSIRKYTDKPVEEEDIEKLLRAAMAAPSAGNQQPWHFIVVTDREKLDKIAEAHPY-GKMLKEAPLAIVvcgdpsKEK 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2221775887 246 RSYFYsigernqlYIDGGIYLMNLLYAFHYYGIAACtahW-GLLNDAD--SKMEDLLGLSPAEQVICIVSFGYPKE 318
Cdd:cd02150    81 APGYW--------VQDCSAATENILLAAHALGLGAV---WlGVYPFEErvKAIREILNIPENIIPFCVIALGYPAE 145
iodotyrosine_dehalogenase cd02144
iodotyrosine dehalogenase; Iodotyrosine dehalogenase catalyzes the removal of iodine from the ...
 167-223 4.19e-09

iodotyrosine dehalogenase; Iodotyrosine dehalogenase catalyzes the removal of iodine from the 3, 5 positions of L-tyosine in thyroid, liver and kidney, using NADPH as electron donor. This enzyme is a homolog of the nitroreductase family. These enzymes are usually homodimers.


Pssm-ID: 380320  Cd Length: 192  Bit Score: 55.62  E-value: 4.19e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2221775887 167 FFDFAKSRSSVREFSEALVPHDVLEDVINLANTAPSVCNRQGVSVVIVEDKDKIQQI 223
Cdd:cd02144     1 FYELMKKRRSVRDFSSEPVPREVIENAIRTAGTAPSGANTQPWTFVVVSDPEIKRKI 57
nitroreductase cd20610
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
 172-315 2.12e-07

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380331 [Multi-domain]  Cd Length: 167  Bit Score: 49.97  E-value: 2.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221775887 172 KSRSSVREFSEALVPHDVLEDVINLANTAPSVCNRQGVSVVIVEDKDKIQQILDIQKGLAGYTSISQLAVIKSN------ 245
Cdd:cd20610     2 KKRRSIRKFKPDPVPKEDIEKILEAANWAPSGMNRQNWEFVVVKGGEKIEKIGISIKKKNEEIARLLEKVFAEKpirfrk 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221775887 246 -RSYFYSIGERNQL-------YIDGGIYLM----------NLLYAFHYYGIAACtahW--GLLNDADSkMEDLLGLSPAE 305
Cdd:cd20610    82 fRRFFTLFGGAPVLvvvytepYKPPEERKPdlqsvsaaiqNLLLAAHALGLGTC---WmtGPLYAEDE-IEEILEIPDDK 157

                         170
                  ....*....|
gi 2221775887 306 QVICIVSFGY 315
Cdd:cd20610   158 ELVAVTPLGY 167
NfsA-like cd02146
nitroreductase similar to Escherichia coli NfsA; This family contains NADPH-dependent flavin ...
 168-319 8.71e-07

nitroreductase similar to Escherichia coli NfsA; This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as an electron donor. Oxygen-insensitive nitroreductase, such as NfsA protein in Escherichia coli, catalyzes reduction of nitrocompounds using NADPH as electron donor.


Pssm-ID: 380322 [Multi-domain]  Cd Length: 229  Bit Score: 49.16  E-value: 8.71e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221775887 168 FDFAKSRSSVREFSEALVPHDVLEDVINLANTAPSVCNRQGVSVVIVED---KDKIQQILDIQKGLAGyTSISQLAVIKS 244
Cdd:cd02146     2 IETILNHRSVRKFTDEPLTDETLETLIAAAQSASTSSNLQAYSVIVVTDpelREKLAELAGNQPYVAQ-APVFLVFCADL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221775887 245 NRsyFYSIGERNQLYIDGGIYLMNLLYAFHYYGIAA---CTAH----------WGLLNDADsKMEDLLGLsPaEQVICIV 311
Cdd:cd02146    81 YR--HQKIAEEAGGKDVGLDYLESFLVGVVDAALAAqnaLVAAeslglgivyiGGIRNNPE-EVIELLGL-P-EYVFPLF 155

                         170
                  ....*....|
gi 2221775887 312 --SFGYPKET 319
Cdd:cd02146   156 glTVGHPDPT 165
BluB cd02145
5,6-dimethylbenzimidazole synthase; BluB catalyzes the O2-dependent conversion of FMNH2 to 5, ...
 172-234 1.75e-05

5,6-dimethylbenzimidazole synthase; BluB catalyzes the O2-dependent conversion of FMNH2 to 5,6-dimethylbenzimidazole (DMB), a component of vitamin B12; is is a subfamily of the nitroreductase family; nitroreductases typically reduce their substrates by using NAD(P)H as electron donor and often use FMN as a cofactor.


Pssm-ID: 380321  Cd Length: 196  Bit Score: 45.04  E-value: 1.75e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2221775887 172 KSRSSVREFSEALVPHDVLEDVINLANTAPSVCNRQGVSVVIVEDKDKIQQILDI-----QKGLAGYT 234
Cdd:cd02145     5 RWRRDVRHFRPDPVPEEVLERLLQAAHLAPSVGLMQPWRFVRVRSAATRKAVHELfqranAEAAEMYT 72
nitroreductase cd03370
uncharacterized nitroreductase family proteins; Nitroreductase family containing Thermus ...
 171-319 3.05e-05

uncharacterized nitroreductase family proteins; Nitroreductase family containing Thermus thermophilus NADH oxidase and other, uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380327 [Multi-domain]  Cd Length: 191  Bit Score: 44.23  E-value: 3.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221775887 171 AKSRSSVREFSEALVPHDVLEDVINLANTAPSVCNRQGVSVVIVEDKDKIQQILDIQKGLAGYTSISQLAVIKSN----- 245
Cdd:cd03370     5 IESRRSIRKYTQEPVPDEDLREILRLAGLAPSAWNIQPWRFVVVRDAELKEQLQAAAYGQAQVTSAPAVIVIYSDmedal 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221775887 246 -----------------------RSYF--YSIGER-----NQLYIDGGiYLMNLLYAFHYygiaACTAHWGLlnDADsKM 295
Cdd:cd03370    85 anleetihpglseerrqreaaglRGAFgkMSVEQRgqwglAQANIALG-FLLLAAQSLGY----DTSPMLGF--DPE-KV 156

                         170       180
                  ....*....|....*....|....
gi 2221775887 296 EDLLGLSPAEQVICIVSFGYPKET 319
Cdd:cd03370   157 KALLGLPEHVTIAALVALGKPAEE 180
YdjA-like cd02135
nitroreductase family protein similar to Escherichia coli YdjA; A subfamily of the ...
 168-315 8.07e-05

nitroreductase family protein similar to Escherichia coli YdjA; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase YdjA from Escherichia coli. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. Members of this family are also called NADH dehydrogenase, oxygen-insensitive NAD(P)H nitrogenase or dihydropteridine reductase.


Pssm-ID: 380312 [Multi-domain]  Cd Length: 162  Bit Score: 42.59  E-value: 8.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221775887 168 FDFAKSRSSVREFSE-ALVPHDVLEDVINLANTAPSVCNRQGVSVVIVEDKDKIQQILDIQKGLAGYTSISQLAVIKSNR 246
Cdd:cd02135     1 LELIKTRRSIRKFKLtGAPPEEQLEELLEAAMWAPNHGKLEPWRFIVVTGEGRERLAELLAAAAAARAPGADPEKLEKAR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221775887 247 SYF----------YSIGERNQL-----YIDGGIYLMNLLYAFHYYGIAACTAHWGLLNDADskMEDLLGLSPAEQVICIV 311
Cdd:cd02135    81 EKAlrapvviavvAKPDEDPKVpeweqYAAVGAAVQNLLLAAHALGLGAVWRTGPVTYDPA--VREALGLPEDERIVGFL 158


                  ....
gi 2221775887 312 SFGY 315
Cdd:cd02135   159 YLGT 162
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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