|
Name |
Accession |
Description |
Interval |
E-value |
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
12-360 |
1.75e-63 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 207.10 E-value: 1.75e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 12 QFLWRLSITNMIVITAFILLSGWSIYNAACSLADGLGSMNEQKQEKFNAVLFQYLWFFSIGAIVIGSLIHFYITRKLIEP 91
Cdd:COG5002 38 LLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAAL 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 92 IKKLIESTKRMKTGHYPGPIDVKTKDETGQLIGHFNDlVQQLKVNEQHRQKVISDLSHEFRTPLSNLNGYLKALCNGVVD 171
Cdd:COG5002 118 LLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERD-ITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGAAD 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 172 GDV---KLYQSLYDESQRITSMVKQLEQLKEWDyiSNQTFLEKKPVDMQLILTKSVEMFHWTLENAGMSVEFN--TEHGV 246
Cdd:COG5002 197 DPEerrEYLEIILEEAERLSRLVNDLLDLSRLE--SGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDlpEDPLL 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 247 INADSIGISQVIDNLLDNAIQYYGGEGPIFIKGERLVDRYRVSVAGTGQAIPTENPDRLFERFYRTDTSRSYHSGGTGLG 326
Cdd:COG5002 275 VLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGLG 354
|
330 340 350
....*....|....*....|....*....|....*.
gi 2225790502 327 LAISKEIIAHHGGEIGVWSDRDfH--TFWFTLPLWK 360
Cdd:COG5002 355 LAIVKHIVEAHGGRIWVESEPG-KgtTFTITLPLAR 389
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
125-358 |
4.47e-55 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 180.49 E-value: 4.47e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 125 HFNDLVQQLKVNEQHRQKVISDLSHEFRTPLSNLNGYLKALCNGVVDGD---VKLYQSLYDESQRITSMVkqlEQLKEWD 201
Cdd:COG2205 1 ELEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPeerRELLEIIRESAERLLRLI---EDLLDLS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 202 YISNQTF-LEKKPVDMQLILTKSVEMFHWTLENAGMSVEFNT--EHGVINADSIGISQVIDNLLDNAIQYYGGEGPIFIK 278
Cdd:COG2205 78 RLESGKLsLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLppELPLVYADPELLEQVLANLLDNAIKYSPPGGTITIS 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 279 GERLVDRYRVSVAGTGQAIPTENPDRLFERFYRTDTSRSYhsGGTGLGLAISKEIIAHHGGEIGVWSDRDF-HTFWFTLP 357
Cdd:COG2205 158 ARREGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRGE--GGTGLGLAIVKRIVEAHGGTIWVESEPGGgTTFTVTLP 235
|
.
gi 2225790502 358 L 358
Cdd:COG2205 236 L 236
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
60-358 |
2.24e-52 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 176.25 E-value: 2.24e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 60 AVLFQYLWFFSIGAIVIGSLIHFYITRKLIEPIKKLIESTKRMKTGHYPGPIDVKTKDETGQLIGHFNDLVQQLKVNEQH 139
Cdd:COG0642 30 LLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLEEANEA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 140 RQKVISDLSHEFRTPLSNLNGYLKALCNGVVDGDVKLYQSLYDESQRITSMVKQLEQLKEWDyiSNQTFLEKKPVDMQLI 219
Cdd:COG0642 110 KSRFLANVSHELRTPLTAIRGYLELLLEELDEEQREYLETILRSADRLLRLINDLLDLSRLE--AGKLELEPEPVDLAEL 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 220 LTKSVEMFHWTLENAGMSVEFNTEHGV--INADSIGISQVIDNLLDNAIQYYGGEGPIFIKGERLVDRYRVSVAGTGQAI 297
Cdd:COG0642 188 LEEVVELFRPLAEEKGIELELDLPDDLptVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRREGDRVRISVEDTGPGI 267
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2225790502 298 PTENPDRLFERFYRTDTSRSYhsGGTGLGLAISKEIIAHHGGEIGVWSDRDFHT-FWFTLPL 358
Cdd:COG0642 268 PPEDLERIFEPFFRTDPSRRG--GGTGLGLAIVKRIVELHGGTIEVESEPGKGTtFTVTLPL 327
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
49-341 |
2.29e-52 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 180.02 E-value: 2.29e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 49 SMNEQKQEKfnavlfQYLWFFSIGAIVIGSLIHFYITRKLIEPIKKLIESTKRMKTGHYPGPIDVKTKDETGQLIGHFND 128
Cdd:NF012163 155 DINFDSQQK------RASWLIVALALLLAALAAFLLARGLLAPVKRLVEATHRLAAGDYTTRVTPTSNDELGKLAQDFNQ 228
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 129 LVQQLKVNEQHRQKVISDLSHEFRTPLSNLNGYLKALCNGVVDGDVKLYQSLYDESQRITSMVKQLEQLKEWDyiSNQTF 208
Cdd:NF012163 229 LASTLEKNEQMRRDFMADISHELRTPLAVLRAELEAIQDGIRKFTPESLDSLQAEVGTLTKLVDDLHDLSMSD--EGALA 306
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 209 LEKKPVDMQLILTKSVEMFHWTLENAGMSVEFNTEHG-VINADSIGISQVIDNLLDNAIQYYGGEGPIFIKGERLVDRYR 287
Cdd:NF012163 307 YQKASVDLVPLLEVEGGAFRERFASAGLELEVSLPDSsLVFGDRDRLMQLFNNLLENSLRYTDSGGSLHISASQRPKEVT 386
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 2225790502 288 VSVAGTGQAIPTENPDRLFERFYRTDTSRSYHSGGTGLGLAISKEIIAHHGGEI 341
Cdd:NF012163 387 LTVADSAPGVSDEQLARLFERFYRVEVSRNRASGGSGLGLAISLNIVQAHGGTL 440
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
64-357 |
4.58e-48 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 168.33 E-value: 4.58e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 64 QYLWFFSIGAIVIGSLIHFYITRKLIEPIKKLIESTKRMKTGHYPGPIDV-KTKDETGQLIGHFNDLVQQLKVNEQHRQK 142
Cdd:TIGR01386 164 KWLILIAVLLVLLTALLGWWITRLGLEPLRRLSAVAARISPESLDQRLDPsRAPAELRELAQSFNAMLGRLEDAFQRLSQ 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 143 VISDLSHEFRTPLSNLNGYLKALCNGVVDGD--VKLYQSLYDESQRITSMVKQLEQLKEWDyiSNQTFLEKKPVDMQLIL 220
Cdd:TIGR01386 244 FSADLAHELRTPLTNLLGQTQVALSQPRTGEeyREVLESNLEELERLSRMVSDMLFLARAD--NGQLALERVRLDLAAEL 321
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 221 TKSVEMFHWTLENAGMSVEFNTEhGVINADSIGISQVIDNLLDNAIQYYGGEGPIFIKGERLVDRYRVSVAGTGQAIPTE 300
Cdd:TIGR01386 322 AKVAEYFEPLAEERGVRIRVEGE-GLVRGDPQMFRRAISNLLSNALRHTPDGGTITVRIERRSDEVRVSVSNPGPGIPPE 400
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 2225790502 301 NPDRLFERFYRTDTSRSYHSGGTGLGLAISKEIIAHHGGEIGVWSDRDFHTFWFTLP 357
Cdd:TIGR01386 401 HLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASAESPDGKTRFILRFP 457
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
67-341 |
1.49e-46 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 164.42 E-value: 1.49e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 67 WFFSIGAIVIGSLIHFYITRKLIEPIKKLIESTKRMKTGHYPGPIDVKTKDETGQLIGHFNDLVQQLKVNEQHRQKVISD 146
Cdd:PRK10549 167 WLIVALSTLLAALATFLLARGLLAPVKRLVEGTHKLAAGDFTTRVTPTSRDELGRLAQDFNQLASTLEKNEQMRRDFMAD 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 147 LSHEFRTPLSNLNGYLKALCNGVVDGDVKLYQSLYDESQRITSMVKQLEQLKewdyISNQTFL--EKKPVDMQLILTKSV 224
Cdd:PRK10549 247 ISHELRTPLAVLRGELEAIQDGVRKFTPESVASLQAEVGTLTKLVDDLHQLS----LSDEGALayRKTPVDLVPLLEVAG 322
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 225 EMFHWTLENAGMSVEFN-TEHGVINADSIGISQVIDNLLDNAIQYYGGEGPIFIKGERLVDRYRVSVAGTGQAIPTENPD 303
Cdd:PRK10549 323 GAFRERFASRGLTLQLSlPDSATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLRLTFADSAPGVSDEQLQ 402
|
250 260 270
....*....|....*....|....*....|....*...
gi 2225790502 304 RLFERFYRTDTSRSYHSGGTGLGLAISKEIIAHHGGEI 341
Cdd:PRK10549 403 KLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRI 440
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
130-345 |
1.21e-39 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 143.12 E-value: 1.21e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 130 VQQLKVNEQHRQKVISDLSHEFRTPLSNLNGYLKALCNGVVDGDV---KLYQSLYDESQRITSMVKQLEQLKEWDYISNQ 206
Cdd:TIGR02966 104 VTRLRRLEQMRRDFVANVSHELRTPLTVLRGYLETLADGPDEDPEewnRALEIMLEQSQRMQSLVEDLLTLSRLESAASP 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 207 tfLEKKPVDMQLILTKSVEMFHWTLENAGMSVEFNTEHGV-INADSIGISQVIDNLLDNAIQYYGGEGPIFIKGERLVDR 285
Cdd:TIGR02966 184 --LEDEPVDMPALLDHLRDEAEALSQGKNHQITFEIDGGVdVLGDEDELRSAFSNLVSNAIKYTPEGGTITVRWRRDGGG 261
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 286 YRVSVAGTGQAIPTENPDRLFERFYRTDTSRSYHSGGTGLGLAISKEIIAHHGGEIGVWS 345
Cdd:TIGR02966 262 AEFSVTDTGIGIAPEHLPRLTERFYRVDKSRSRDTGGTGLGLAIVKHVLSRHHARLEIES 321
|
|
| HK_WalK |
NF033092 |
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ... |
128-358 |
1.28e-36 |
|
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.
Pssm-ID: 467964 [Multi-domain] Cd Length: 594 Bit Score: 139.50 E-value: 1.28e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 128 DLVQQLKVnEQHRQKVISDLSHEFRTPLSNLNGYLKALCNGVV-DGDV-----KLYQslyDESQRITSMVKQLEQLKEWD 201
Cdd:NF033092 361 DVTEQEKI-EQERREFVANVSHELRTPLTTMRSYLEALADGAWkDPELaprflGVTQ---NETERMIRLVNDLLQLSRMD 436
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 202 yiSNQTFLEKKPVDMQLILTKSVEMFHWTLENAGMSVEFNTEHGVINA--DSIGISQVIDNLLDNAIQYYGGEGPIFIKG 279
Cdd:NF033092 437 --SKDYKLNKEWVNFNEFFNYIIDRFEMILKNKNITFKREFPKRDLWVeiDTDKITQVLDNIISNAIKYSPEGGTITFRL 514
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 280 ERLVDRYRVSVAGTGQAIPTENPDRLFERFYRTDTSRSYHSGGTGLGLAISKEIIAHHGGEIgvWSDRDFH---TFWFTL 356
Cdd:NF033092 515 LETHNRIIISISDQGLGIPKKDLDKIFDRFYRVDKARSRKMGGTGLGLAIAKEVVEAHGGRI--WAESEEGkgtTIYFTL 592
|
..
gi 2225790502 357 PL 358
Cdd:NF033092 593 PY 594
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
148-357 |
5.28e-32 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 125.67 E-value: 5.28e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 148 SHEFRTPLSNLNGYLKAL---CNGVVDGDVKLY-QSLYDESQRITSMVKQLeqLkewDY--ISNQTfLEKKPVDMQLILT 221
Cdd:COG4251 290 SHDLREPLRKISGFSQLLeedYGDKLDEEGREYlERIRDAAERMQALIDDL--L---AYsrVGRQE-LEFEPVDLNELLE 363
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 222 KSVEMFHWTLENAGMSVEFnTEHGVINADSIGISQVIDNLLDNAIQYYGGEGP--IFIKGERLVDRYRVSVA--GTGqaI 297
Cdd:COG4251 364 EVLEDLEPRIEERGAEIEV-GPLPTVRGDPTLLRQVFQNLISNAIKYSRPGEPprIEIGAEREGGEWVFSVRdnGIG--I 440
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2225790502 298 PTENPDRLFERFYRTDTSRSYhsGGTGLGLAISKEIIAHHGGEIGVWSDRDFH-TFWFTLP 357
Cdd:COG4251 441 DPEYAEKIFEIFQRLHSRDEY--EGTGIGLAIVKKIVERHGGRIWVESEPGEGaTFYFTLP 499
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
147-358 |
5.34e-32 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 123.37 E-value: 5.34e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 147 LSHEFRTPLSNLNGYLKALCNGVVDGD-----VKLYQSLYDESQRITSMVKQLEQLkewdyiSNQTFLEKKPVDMQLILT 221
Cdd:COG4191 149 IAHEINNPLAAILGNAELLRRRLEDEPdpeelREALERILEGAERAAEIVRSLRAF------SRRDEEEREPVDLNELID 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 222 KSVEMFHWTLENAGMSVEFNTEHGV--INADSIGISQVIDNLLDNAIQ-YYGGEGP-IFIKGERLVDRYRVSVAGTGQAI 297
Cdd:COG4191 223 EALELLRPRLKARGIEVELDLPPDLppVLGDPGQLEQVLLNLLINAIDaMEEGEGGrITISTRREGDYVVISVRDNGPGI 302
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2225790502 298 PTENPDRLFERFYrtdTSRSyHSGGTGLGLAISKEIIAHHGGEIGVWSDRDFHT-FWFTLPL 358
Cdd:COG4191 303 PPEVLERIFEPFF---TTKP-VGKGTGLGLSISYGIVEKHGGRIEVESEPGGGTtFTITLPL 360
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
68-358 |
7.84e-32 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 123.92 E-value: 7.84e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 68 FFSIGAIVIGSLIHFYITRKLIEPIKKLIESTKRMKTGHYPGPIDVKTKDETGQLIGHFNDLVQQLK------------- 134
Cdd:COG5000 13 LIALLLLLLALWLALLLARRLTRPLRRLAEATRAVAAGDLSVRLPVTGDDEIGELARAFNRMTDQLKeqreeleerrryl 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 135 -------------VNEQHR------------------------------------------------------------- 140
Cdd:COG5000 93 etilenlpagvivLDADGRitlanpaaerllgipleeligkpleellpeldlaellrealergwqeeieltrdgrrtllv 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 141 -----------------------------QKVISDLSHEFRTPLSNLNGY---LKALCNGVVDGDVKLYQSLYD----ES 184
Cdd:COG5000 173 rasplrddgyvivfdditellraerlaawGELARRIAHEIKNPLTPIQLSaerLRRKLADKLEEDREDLERALDtiirQV 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 185 QRITSMVKQLEQLkewdyiSNQTFLEKKPVDMQLILTKSVEMFHWTLENAGMSVEFNT--EHGVINADSIGISQVIDNLL 262
Cdd:COG5000 253 DRLKRIVDEFLDF------ARLPEPQLEPVDLNELLREVLALYEPALKEKDIRLELDLdpDLPEVLADRDQLEQVLINLL 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 263 DNAIQYYGGEGPIFIKGERLVDRYRVSVAGTGQAIPTENPDRLFERFYrtdTSRsyhSGGTGLGLAISKEIIAHHGGEIG 342
Cdd:COG5000 327 KNAIEAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFF---TTK---PKGTGLGLAIVKKIVEEHGGTIE 400
|
410
....*....|....*...
gi 2225790502 343 VwSDRDFH--TFWFTLPL 358
Cdd:COG5000 401 L-ESRPGGgtTFTIRLPL 417
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
118-357 |
3.19e-31 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 122.96 E-value: 3.19e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 118 ETGQLIGHFNDLVQQLKvNEQHRQKVIS-DLSHEFRTPLSNLNGYLK-ALCNGVVDGDVK--LYQSLyDESQRITSMVKQ 193
Cdd:PRK09835 240 ELEQLVLSFNHMIERIE-DVFTRQSNFSaDIAHEIRTPITNLITQTEiALSQSRSQKELEdvLYSNL-EELTRMAKMVSD 317
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 194 LEQLKEWDyiSNQTFLEKKPVDMQLILTKSVEMFHWTLENAGMSVEFNTEHGVINADSIGISQVIDNLLDNAIQYYGGEG 273
Cdd:PRK09835 318 MLFLAQAD--NNQLIPEKKMLDLADEVGKVFDFFEAWAEERGVELRFVGDPCQVAGDPLMLRRAISNLLSNALRYTPAGE 395
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 274 PIFIKGERLVDRYRVSVAGTGQAIPTENPDRLFERFYRTDTSRSYHSGGTGLGLAISKEIIAHHGGEIGVWSDRDFHTFW 353
Cdd:PRK09835 396 AITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDARGTRFV 475
|
....
gi 2225790502 354 FTLP 357
Cdd:PRK09835 476 ISLP 479
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
74-357 |
3.31e-30 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 120.52 E-value: 3.31e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 74 IVIGSLIHFYITRKLIEPIKKLIESTKRMKTGHYPGPIDVKTKDETGQLIGHFNDL-------VQQLKVNEQHRQKVISD 146
Cdd:NF040691 198 VVLLGLIAWLVTRQVVAPVRSAARTAERFAAGDLSERMPVKGEDDLARLARSFNQMadslqrqIRQLEELSRLQQRFVSD 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 147 LSHEFRTPLSNLNGYLKALCNGVVDGDVKLYQS---LYDESQRITSMVKQLEQLKEWDyiSNQTFLEKKPVDMQLILTKS 223
Cdd:NF040691 278 VSHELRTPLTTIRMAADVIHDSRDDFDPATARSaelLHTELDRFESLLSDLLEISRFD--AGAAELDVEPVDLRPLVRRV 355
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 224 VEMFHWTLENAGMSVEFN--TEHGVINADSIGISQVIDNLLDNAIQYygGEG-PIFIKGERLVDRYRVSVAGTGQAIPTE 300
Cdd:NF040691 356 VDALRQLAERAGVELRVDapGTPVVAEVDPRRVERVLRNLVVNAIEH--GEGkPVVVTVAQDDTAVAVTVRDHGVGLKPG 433
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 2225790502 301 NPDRLFERFYRTDTSRSYHSGGTGLGLAISKEIIAHHGGEIGVWSDR-DFHTFWFTLP 357
Cdd:NF040691 434 EVALVFDRFWRADPARARTTGGTGLGLAIALEDARLHGGWLEAWGRPgQGSQFRLTLP 491
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
249-358 |
4.25e-30 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 111.20 E-value: 4.25e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 249 ADSIGISQVIDNLLDNAIQYYGGEGPIFIKGERLVDRYRVSVAGTGQAIPTENPDRLFERFYRTDtSRSYHSGGTGLGLA 328
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTD-KRSRKIGGTGLGLS 79
|
90 100 110
....*....|....*....|....*....|.
gi 2225790502 329 ISKEIIAHHGGEIGVWSDRDFHT-FWFTLPL 358
Cdd:smart00387 80 IVKKLVELHGGEISVESEPGGGTtFTITLPL 110
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
254-356 |
1.59e-28 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 106.53 E-value: 1.59e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 254 ISQVIDNLLDNAIQYYGGEGPIFIKGERLVDRYRVSVAGTGQAIPTENPDRLFERFYRTDTSRsyHSGGTGLGLAISKEI 333
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSR--EGGGTGLGLAIVRRI 78
|
90 100
....*....|....*....|....
gi 2225790502 334 IAHHGGEIGVWSDRDFHT-FWFTL 356
Cdd:cd00075 79 VEAHGGRITVESEPGGGTtFTVTL 102
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
113-358 |
2.20e-26 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 107.62 E-value: 2.20e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 113 VKTKDETGQLIGHFNDLVQQLKVNEQHRQ--------KVISDLSHEFRTPLSNLNGYLKALCNGVVDGDVKLY-QSLYDE 183
Cdd:COG3852 100 LRDAEGEGGVLLVLRDITERKRLERELRRaeklaavgELAAGLAHEIRNPLTGIRGAAQLLERELPDDELREYtQLIIEE 179
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 184 SQRITSMVKQLEQLkewdyiSNQTFLEKKPVDMQLILTKSVEMFHWTLeNAGMSVEFNTEHGV--INADSIGISQVIDNL 261
Cdd:COG3852 180 ADRLNNLVDRLLSF------SRPRPPEREPVNLHEVLERVLELLRAEA-PKNIRIVRDYDPSLpeVLGDPDQLIQVLLNL 252
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 262 LDNAIQYYGGEG---------PIFIKGERLVDRY-RVSVAGTGQAIPTENPDRLFERFYrtdTSRSyhsGGTGLGLAISK 331
Cdd:COG3852 253 VRNAAEAMPEGGtitirtrveRQVTLGGLRPRLYvRIEVIDNGPGIPEEILDRIFEPFF---TTKE---KGTGLGLAIVQ 326
|
250 260
....*....|....*....|....*...
gi 2225790502 332 EIIAHHGGEIGVWSDRDFHT-FWFTLPL 358
Cdd:COG3852 327 KIVEQHGGTIEVESEPGKGTtFRIYLPL 354
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
249-358 |
5.38e-26 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 100.14 E-value: 5.38e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 249 ADSIGISQVIDNLLDNAIQYYGGEGPIFIKGERlVDRYRVSVAGTGQAIPTENPDRLFERFYRTDTSRSyhsGGTGLGLA 328
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLSE-GGELTLTVEDNGIGIPPEDLPRIFEPFSTADKRGG---GGTGLGLS 76
|
90 100 110
....*....|....*....|....*....|.
gi 2225790502 329 ISKEIIAHHGGEIGVWSDRDFHT-FWFTLPL 358
Cdd:pfam02518 77 IVRKLVELLGGTITVESEPGGGTtVTLTLPL 107
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
130-357 |
1.21e-25 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 106.63 E-value: 1.21e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 130 VQQLKVNEQHRQKVISDLSHEFRTPLSNLNGYLKALCNGVVDGDV--KLYQSLYDESQRITSMVKQLEQLKEWDyISNQT 207
Cdd:PRK11006 194 VTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMQDQPLEGALreKALHTMREQTQRMEGLVKQLLTLSKIE-AAPTI 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 208 FLEKKpVDMQLILtKSVEMFHWTLENAGMSVEFNTEHGV-INADSIGISQVIDNLLDNAIQYYGGEGPIFIKGERLVDRY 286
Cdd:PRK11006 273 DLNEK-VDVPMML-RVLEREAQTLSQGKHTITFEVDNSLkVFGNEDQLRSAISNLVYNAVNHTPEGTHITVRWQRVPQGA 350
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2225790502 287 RVSVAGTGQAIPTENPDRLFERFYRTDTSRSYHSGGTGLGLAISKEIIAHHG------GEIGVWSdrdfhTFWFTLP 357
Cdd:PRK11006 351 EFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHDsrleieSEVGKGT-----RFSFVLP 422
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
66-343 |
4.83e-24 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 102.62 E-value: 4.83e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 66 LWFFSIgAIVIGSLIHFYITRkliePIKKLIESTKRMKTGHyPGPIDVKTKDETGQLIGHFNDLVQQLKvNEQHRQKVIS 145
Cdd:PRK11100 189 ALLLGI-ALLIGAGVVWWLNR----SIRRLTRYADAVTEGK-PVPLPKLGSSELRELAQALESMRVKLE-GKAYVEQYVQ 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 146 DLSHEFRTPLSNLNGYLKALCNGVVDGDVKLY-QSLYDESQRITSMVKQLEQLKEwdyISNQTFLEKK-PVDMQLILTKS 223
Cdd:PRK11100 262 TLTHELKSPLAAIRGAAELLQEDPPPEDRARFtGNILTQSARLQQLIDRLLELAR---LEQRQELEVLePVALAALLEEL 338
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 224 VEMFHWTLENAGMSVEFNTEHGVINADSIGISQVIDNLLDNAIQYYGGEGPIFIKGERLVDRYRVSVAGTGQAIPTENPD 303
Cdd:PRK11100 339 VEAREAQAAAKGITLRLRPDDARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQVALSVEDQGPGIPDYALP 418
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 2225790502 304 RLFERFY---RTDTSRSyhsgGTGLGLAISKEIIAHHGGEIGV 343
Cdd:PRK11100 419 RIFERFYslpRPANGRK----STGLGLAFVREVARLHGGEVTL 457
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
116-345 |
8.36e-23 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 99.66 E-value: 8.36e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 116 KDETGQLIG---HFNDLVQQLKVNEQ-HRQ-------KVISDLSHEFRTPLSNLNGYLKALCNGVVDGDVKLYQSL-YDE 183
Cdd:PRK11360 355 HNTHGEMIGalvIFSDLTERKRLQRRvARQerlaalgELVAGVAHEIRNPLTAIRGYVQIWRQQTSDPPSQEYLSVvLRE 434
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 184 SQRITSMVKQLEQLKEWDYISNQtflekkPVDMQLILTKSVEMFHWTLENAGMSVEFNTEHGV--INADSIGISQVIDNL 261
Cdd:PRK11360 435 VDRLNKVIDQLLEFSRPRESQWQ------PVSLNALVEEVLQLFQTAGVQARVDFETELDNELppIWADPELLKQVLLNI 508
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 262 LDNAIQYYGGEGPIFIKGERLVDRYR-VSVAGTGQAIPTENPDRLFERFYRTDTSrsyhsgGTGLGLAISKEIIAHHGGE 340
Cdd:PRK11360 509 LINAVQAISARGKIRIRTWQYSDGQVaVSIEDNGCGIDPELLKKIFDPFFTTKAK------GTGLGLALSQRIINAHGGD 582
|
....*
gi 2225790502 341 IGVWS 345
Cdd:PRK11360 583 IEVES 587
|
|
| TMAO_torS |
TIGR02956 |
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the ... |
147-358 |
2.78e-22 |
|
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems]
Pssm-ID: 274362 [Multi-domain] Cd Length: 968 Bit Score: 98.31 E-value: 2.78e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 147 LSHEFRTPLSNLNGYLKALcngvvdGDVKLYQSLYDESQRI----TSMVKQLEQLKEWDYI-SNQTFLEKKPVDMQLILT 221
Cdd:TIGR02956 471 MSHEIRTPLNGILGTLELL------GDTGLTSQQQQYLQVInrsgESLLDILNDILDYSKIeAGHLSISPRPFDLNALLD 544
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 222 KSVEMFHWTLENAGMSVEFNTEHGV---INADSIGISQVIDNLLDNAIQyYGGEGPI----FIKGERLVdryRVSVAGTG 294
Cdd:TIGR02956 545 DVHHLMVSRAQLKGIQLRLNIPEQLpnwWQGDGPRIRQVLINLVGNAIK-FTDRGSVvlrvSLNDDSSL---LFEVEDTG 620
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2225790502 295 QAIPTENPDRLFERFYRTDTSRSyhSGGTGLGLAISKEIIAHHGGEIGVWSDRDF-HTFWFTLPL 358
Cdd:TIGR02956 621 CGIAEEEQATLFDAFTQADGRRR--SGGTGLGLAISQRLVEAMDGELGVESELGVgSCFWFTLPL 683
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
256-341 |
4.59e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 89.83 E-value: 4.59e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 256 QVIDNLLDNAIQYYGGEGPIFIKGERLVDRYRVSVAGTGQAIPTENPDRLFERFYRTDTSRSYHSGGTGLGLAISKEIIA 335
Cdd:cd16946 7 QLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAICHNIAL 86
|
....*.
gi 2225790502 336 HHGGEI 341
Cdd:cd16946 87 AHGGTI 92
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
256-358 |
5.45e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 89.47 E-value: 5.45e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 256 QVIDNLLDNAIQYyGGEGPIFIKGERL-----VDRYRVSVAGTGQAIPTENPDRLFERFYRTDTSRSYHSGGTGLGLAIS 330
Cdd:cd16922 3 QILLNLLGNAIKF-TEEGEVTLRVSLEeeeedGVQLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAIS 81
|
90 100
....*....|....*....|....*....
gi 2225790502 331 KEIIAHHGGEIGVWSDRDF-HTFWFTLPL 358
Cdd:cd16922 82 KKLVELMGGDISVESEPGQgSTFTFTLPL 110
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
128-359 |
1.03e-21 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 95.02 E-value: 1.03e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 128 DLVQQLKVNEQhrqkVISDLSHEFRTPL-----------SNLNGYLKALCNGVVDgdvKLYQSLYDESQRITSMVKQL-- 194
Cdd:PRK09303 143 TLLEQLKFKDR----VLAMLAHDLRTPLtaaslaletleLGQIDEDTELKPALIE---QLQDQARRQLEEIERLITDLle 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 195 ------EQLKewdyisnqtfLEKKPVDMQLILTKSVEMFHWTLEnaGMSVEFNTEHGV----INADSIGISQVIDNLLDN 264
Cdd:PRK09303 216 vgrtrwEALR----------FNPQKLDLGSLCQEVILELEKRWL--AKSLEIQTDIPSdlpsVYADQERIRQVLLNLLDN 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 265 AIQYYGGEGPIFIKG-ERLVDRYRVSVAGTGQAIPTENPDRLFERFYRTDtsRSYHSGGTGLGLAISKEIIAHHGGEIGV 343
Cdd:PRK09303 284 AIKYTPEGGTITLSMlHRTTQKVQVSICDTGPGIPEEEQERIFEDRVRLP--RDEGTEGYGIGLSVCRRIVRVHYGQIWV 361
|
250 260
....*....|....*....|
gi 2225790502 344 WSDRD----FHtfwFTLPLW 359
Cdd:PRK09303 362 DSEPGqgscFH---FTLPVY 378
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
257-357 |
2.65e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 87.44 E-value: 2.65e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 257 VIDNLLDNAIQYYGGEGPIFIKGERLVDRYRVSVAGTGQAIPTENPDRLFERFYRTDTSRsyHSGGTGLGLAISKEIIAH 336
Cdd:cd16923 4 VFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSR--NTEGAGLGLSIAKAIIEL 81
|
90 100
....*....|....*....|.
gi 2225790502 337 HGGEIGVWSDRDFHTFWFTLP 357
Cdd:cd16923 82 HGGSASAEYDDNHDLFKVRLP 102
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
148-358 |
1.35e-19 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 89.65 E-value: 1.35e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 148 SHEFRTPLSNLNGYLKaLCNGVVDGDVKLYQSLYD-ESQRITSMVKQLEQL---KEWDYisnqtflekKPVDMQLILTKS 223
Cdd:COG5809 278 AHEIRNPLTSLKGFIQ-LLKDTIDEEQKTYLDIMLsELDRIESIISEFLVLakpQAIKY---------EPKDLNTLIEEV 347
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 224 VEMF--HWTLENAGMSVEFNTEHGVINADSIGISQVIDNLLDNAIQYYGGEGPIFIKGERLVDRY-RVSVAGTGQAIPTE 300
Cdd:COG5809 348 IPLLqpQALLKNVQIELELEDDIPDILGDENQLKQVFINLLKNAIEAMPEGGNITIETKAEDDDKvVISVTDEGCGIPEE 427
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 2225790502 301 NPDRLFERFYRTDtsrsyhSGGTGLGLAISKEIIAHHGGEIGVWSDRDFHT-FWFTLPL 358
Cdd:COG5809 428 RLKKLGEPFYTTK------EKGTGLGLMVSYKIIEEHGGKITVESEVGKGTtFSITLPI 480
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
50-341 |
2.14e-19 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 88.81 E-value: 2.14e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 50 MNEQKQEKFnAVLFQYLwfFSIGAIVIGSLIHFyiTRKLIEPIKKLIESTKRMKTGHYPGPIDVKTKDETGQLIGHFNDL 129
Cdd:PRK09467 144 LTEIHQGDF-SPLFRYT--LAIGLLSVAGGWLF--IRIQNRPLVALEHAALQVGKGEIPPPLREYGASEVRSVTRAFNQM 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 130 VQQLKVNEQHRQKVISDLSHEFRTPL----------SNLNGYLKalcngvvDGDVKlyqslyDesqrITSMVKQLEQLke 199
Cdd:PRK09467 219 AAGIKQLEDDRTLLMAGVSHDLRTPLtrirlatemmSEEDGYLA-------ESINK------D----IEECNAIIEQF-- 279
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 200 WDYISNQTFLEKKPVDMQLILTKSV--EMfHWTLEnagMSVEFNTEHGVINADSIGISQVIDNLLDNAIQYygGEGPIFI 277
Cdd:PRK09467 280 IDYLRTGQEMPMEMADLNALLGEVIaaES-GYERE---IETALQPGPIEVPMNPIAIKRALANLVVNAARY--GNGWIKV 353
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2225790502 278 KGERLVDRYRVSVAGTGQAIPTENPDRLFERFYRTDTSRSyhSGGTGLGLAISKEIIAHHGGEI 341
Cdd:PRK09467 354 SSGTEGKRAWFQVEDDGPGIPPEQLKHLFQPFTRGDSARG--SSGTGLGLAIVKRIVDQHNGKV 415
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
148-345 |
6.14e-19 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 87.53 E-value: 6.14e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 148 SHEFRTPLSNLNGYLKALCNGVVDG--DVKLYQSLYDESQRITSMVKQLEQLkewdyiSNQTFLEKKPVDMQLILTKSVE 225
Cdd:PRK10364 245 AHEIRNPLSSIKGLAKYFAERAPAGgeAHQLAQVMAKEADRLNRVVSELLEL------VKPTHLALQAVDLNDLINHSLQ 318
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 226 MFHWTLENAGMSVEFNTEHGV--INADSIGISQVIDNLLDNAIQYYGGEGPIFIKGERLVDRYRVSVAGTGQAIPTENPD 303
Cdd:PRK10364 319 LVSQDANSREIQLRFTANDTLpeIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGKGIAADQLE 398
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 2225790502 304 RLFERFYRTDTSrsyhsgGTGLGLAISKEIIAHHGGEIGVWS 345
Cdd:PRK10364 399 AIFTPYFTTKAE------GTGLGLAVVHNIVEQHGGTIQVAS 434
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
14-341 |
7.19e-19 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 87.88 E-value: 7.19e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 14 LWRLSITN--MIVITAFILLS-----GWSIynaACSLADGLGSMNEQKQEKfnavLFQYlwffSIGAIVIGSLIHFYITR 86
Cdd:TIGR03785 360 TWRLSPDSkaVILSAAYPIWIdtevlGAVI---AEQTTNGIRTLRNSALEK----LFNV----ILAIMSIGTLALFGFAS 428
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 87 KLIEPIKKL-------IESTKRMkTGHYPGPidvKTKDETGQLIGHFNDLVQQLKVNEQHRQKVISDLSHEFRTPLSNLN 159
Cdd:TIGR03785 429 WISWRIRRLsddaeaaIDSQGRI-SGAIPAS---RSRDEIGDLSRSFAQMVARLRQYTHYLENMSSRLSHELRTPVAVVR 504
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 160 GYLKALCNGVVDGDVKLYQSLYDE-----SQRITSM--VKQLEQLkewdyISNQtflEKKPVDMQLILTKSVEMFHWTLE 232
Cdd:TIGR03785 505 SSLENLELQALEQEKQKYLERAREgterlSMILNNMseATRLEQA-----IQSA---EVEDFDLSEVLSGCMQGYQMTYP 576
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 233 NAGMSVEFNTEHGVINADSIGISQVIDNLLDNAIQYYGGEGPIFIKGERLVDRYRVSVAGTGQAIPTENPDRLFERFY-- 310
Cdd:TIGR03785 577 PQRFELNIPETPLVMRGSPELIAQMLDKLVDNAREFSPEDGLIEVGLSQNKSHALLTVSNEGPPLPEDMGEQLFDSMVsv 656
|
330 340 350
....*....|....*....|....*....|.
gi 2225790502 311 RTDTSRSYHSggTGLGLAISKEIIAHHGGEI 341
Cdd:TIGR03785 657 RDQGAQDQPH--LGLGLYIVRLIADFHQGRI 685
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
254-345 |
1.33e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 80.16 E-value: 1.33e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 254 ISQVIDNLLDNAIQYYGGEGPIFIKGERLVDRYRVSVAGTGQAIPTENPDRLFERFYRTDTSRSyhsgGTGLGLAISKEI 333
Cdd:cd16943 4 LNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGE----GTGLGLSLSYRI 79
|
90
....*....|..
gi 2225790502 334 IAHHGGEIGVWS 345
Cdd:cd16943 80 IQKHGGTIRVAS 91
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
254-341 |
8.46e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 77.87 E-value: 8.46e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 254 ISQVIDNLLDNAIQYYGGEgpIFIKGERLVDRYRVSVAGTGQAIPTENPDRLFERFYRTDTSRSyhSGGTGLGLAISKEI 333
Cdd:cd16950 1 LKRVLSNLVDNALRYGGGW--VEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARG--TSGTGLGLAIVQRI 76
|
....*...
gi 2225790502 334 IAHHGGEI 341
Cdd:cd16950 77 SDAHGGSL 84
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
55-360 |
1.05e-17 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 83.83 E-value: 1.05e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 55 QEKFNAVLFQYLWFFSIGAIVIGSLIHFYITRKLIEPIKKLIESTKRMKTGHY-------PGPIDVKtkdETGQligHFN 127
Cdd:PRK09470 157 QSDFINLLFDRPLLLLLVTMLVSTPLLLWLAWSLAKPARKLKNAADEVAQGNLrqhpeleTGPQEFR---QAGA---SFN 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 128 DLVQQLKVNEQHRQKVISDLSHEFRTPLSNLNgylkaLCNGVV---DGDVKLYQSLYDESQRITSMVKQLEQLKewdyiS 204
Cdd:PRK09470 231 QMVTALERMMTSQQRLLSDISHELRTPLTRLQ-----LATALLrrrQGESKELERIETEAQRLDSMINDLLVLS-----R 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 205 NQ--TFLEKKPVDMQliltksvEMFHWTLENA---------GMSVEFNTEHGVINADSIGISQVIDNLLDNAIqYYGG-- 271
Cdd:PRK09470 301 NQqkNHLERETFKAN-------SLWSEVLEDAkfeaeqmgkSLTVSAPPGPWPINGNPNALASALENIVRNAL-RYSHtk 372
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 272 -EGPIFIKGERLvdryRVSVAGTGQAIPTENPDRLFERFYRTDTSRSYHSGGTGLGLAISKEIIAHHGGEigVWSDRD-- 348
Cdd:PRK09470 373 iEVAFSVDKDGL----TITVDDDGPGVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHRGW--VKAEDSpl 446
|
330
....*....|....*
gi 2225790502 349 ---FHTFWftLPLWK 360
Cdd:PRK09470 447 gglRLTIW--LPLYK 459
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
258-345 |
1.46e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 77.24 E-value: 1.46e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 258 IDNLLDNAIQYYGGEGPIFIKGERLVDRYRVSVAGTGQAIPTENPDRLFERFYRTDTSRSYHSGGTGLGLAISKEIIAHH 337
Cdd:cd16952 5 FSNLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHVMSRH 84
|
....*...
gi 2225790502 338 GGEIGVWS 345
Cdd:cd16952 85 DARLLIAS 92
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
137-358 |
2.05e-17 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 83.55 E-value: 2.05e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 137 EQHRQKVISDLSHEFRTPLSNLNGYLKALCngvvdgdvklyQSLYDESQRITSMVKQLEQlkewdYISNQTFLEKKPVDM 216
Cdd:PRK10490 661 EQLRNALLAALSHDLRTPLTVLFGQAEILT-----------LDLASEGSPHARQASEIRQ-----QVLNTTRLVNNLLDM 724
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 217 -----------------QLILTKSVEMFHWTLENAGMSVEFNTEHGVINADSIGISQVIDNLLDNAIQYYGGEGPIFIKG 279
Cdd:PRK10490 725 ariqsggfnlrkewltlEEVVGSALQMLEPGLSGHPINLSLPEPLTLIHVDGPLFERVLINLLENAVKYAGAQAEIGIDA 804
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 280 ERLVDRYRVSVAGTGQAIPTENPDRLFERFYRTDTSRSYhsGGTGLGLAISKEIIAHHGGEIGVwSDRD-----FHtfwF 354
Cdd:PRK10490 805 HVEGERLQLDVWDNGPGIPPGQEQLIFDKFARGNKESAI--PGVGLGLAICRAIVEVHGGTIWA-ENRPeggacFR---V 878
|
....
gi 2225790502 355 TLPL 358
Cdd:PRK10490 879 TLPL 882
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
254-358 |
2.99e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 76.21 E-value: 2.99e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 254 ISQVIDNLLDNAIQYygGEGPIFIKGERLVDRYRVSVAGTGQAIPTENPDRLFERFYRTDTSRSYHSGGTGLGLAISKEI 333
Cdd:cd16949 1 LARALENVLRNALRY--SPSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERA 78
|
90 100
....*....|....*....|....*....
gi 2225790502 334 IAHHGGEIGVwSDRDFH----TFWftLPL 358
Cdd:cd16949 79 IEQHGGKIKA-SNRKPGglrvRIW--LPA 104
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
254-357 |
3.14e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 73.52 E-value: 3.14e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 254 ISQVIDNLLDNAIQYYGGEGP--IFIKGERLVDRYRVSVAGTGQAIPTENPDRLFERFYRTDTSRSYHsgGTGLGLAISK 331
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRRPprIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHSREEYE--GTGVGLAIVR 78
|
90 100
....*....|....*....|....*..
gi 2225790502 332 EIIAHHGGEIGVWSDRD-FHTFWFTLP 357
Cdd:cd16921 79 KIIERHGGRIWLESEPGeGTTFYFTLP 105
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
140-343 |
3.57e-16 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 79.26 E-value: 3.57e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 140 RQKVISDLSHEFRTPLSNLNgYLKALCNGVVDgdvklyqslyDESQRITSMVKQLEQLKE--WDYIS---NQTFLEKKPV 214
Cdd:PRK10604 212 KKQLIDGIAHELRTPLVRLR-YRLEMSDNLSA----------AESQALNRDIGQLEALIEelLTYARldrPQNELHLSEP 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 215 DMQLILTKSVEMFHWTLENAGMSVEFNTEHGVINADSIGISQVIDNLLDNAIQYYGGEGPIFIKGERlvDRYRVSVAGTG 294
Cdd:PRK10604 281 DLPAWLSTHLADIQAVTPEKTVRLDTPHQGDYGALDMRLMERVLDNLLNNALRYAHSRVRVSLLLDG--NQACLIVEDDG 358
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 2225790502 295 QAIPTENPDRLFERFYRTDTSRSYHSGGTGLGLAISKEIIAHHGGEIGV 343
Cdd:PRK10604 359 PGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNC 407
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
250-358 |
1.23e-15 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 78.35 E-value: 1.23e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 250 DSIGISQVIDNLLDNAIQYyGGEGPIFIKGE-RLVD----RYRVSVAGTGQAIPTENPDRLFERFYRTDTSRSYHSGGTG 324
Cdd:PRK11107 405 DPLRLQQIITNLVGNAIKF-TESGNIDILVElRALSntkvQLEVQIRDTGIGISERQQSQLFQAFRQADASISRRHGGTG 483
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 2225790502 325 LGLAISKEIIAHHGGEIGvwsdrdFH-------TFWFTLPL 358
Cdd:PRK11107 484 LGLVITQKLVNEMGGDIS------FHsqpnrgsTFWFHLPL 518
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
149-358 |
3.29e-15 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 76.69 E-value: 3.29e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 149 HEFRTPLSNLNGYLKALCNGVVDGDvKLYQSLYDESQRITSMVKQLEQLKEwdyisNQTfLEKKPVDMQLILtKSVEMFH 228
Cdd:COG5805 296 HEIRNPLTSIKGFLQLLQPGIEDKE-EYFDIMLSELDRIESIISEFLALAK-----PQA-VNKEKENINELI-QDVVTLL 367
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 229 WT---LENAGMSVEFNTEHGVINADSIGISQVIDNLLDNAIQYYGGEGPIFIKGERLVDRYRVSVAGTGQAIPTENPDRL 305
Cdd:COG5805 368 ETeaiLHNIQIRLELLDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNSVIIRVIDEGIGIPEERLKKL 447
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 2225790502 306 FERFYRTDTSrsyhsgGTGLGLAISKEIIAHHGGEIGVWSDRDFHT-FWFTLPL 358
Cdd:COG5805 448 GEPFFTTKEK------GTGLGLMVSYKIIENHNGTIDIDSKVGKGTtFTITLPL 495
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
250-343 |
1.22e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 69.36 E-value: 1.22e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 250 DSIGISQVIDNLLDNAIQYYGGEGPIFIK-GERLVDRYRVSVAGTGqaIPTENPDRLFERFYRTDTSrsyHSGGTGLGLA 328
Cdd:cd16940 10 DALLLFLLLRNLVDNAVRYSPQGSRVEIKlSADDGAVIRVEDNGPG--IDEEELEALFERFYRSDGQ---NYGGSGLGLS 84
|
90
....*....|....*
gi 2225790502 329 ISKEIIAHHGGEIGV 343
Cdd:cd16940 85 IVKRIVELHGGQIFL 99
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
256-341 |
3.38e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 67.98 E-value: 3.38e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 256 QVIDNLLDNAIQYYGGE-GPIFIKGERLVDRYRVSVAGTGQAIPTENPDRLFERFYrTDTSRSYHSG-GTGLGLAISKEI 333
Cdd:cd16953 3 QVLRNLIGNAISFSPPDtGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFY-TERPANEAFGqHSGLGLSISRQI 81
|
....*...
gi 2225790502 334 IAHHGGEI 341
Cdd:cd16953 82 IEAHGGIS 89
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
254-343 |
7.73e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 66.71 E-value: 7.73e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 254 ISQVIDNLLDNAIQYYGG--EGPIFIKGERLVDRYRVSVAGTGQAIPTENPDRLFERFYRT-DTSRsyhsgGTGLGLAIS 330
Cdd:cd16976 1 IQQVLMNLLQNALDAMGKveNPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTkPVGK-----GTGLGLSIS 75
|
90
....*....|...
gi 2225790502 331 KEIIAHHGGEIGV 343
Cdd:cd16976 76 YGIVEEHGGRLSV 88
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
69-345 |
1.05e-13 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 72.03 E-value: 1.05e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 69 FSIGAIVIGSLI------HFYITRKLIEPIKKLIESTKRMKTGHYPGPIDVKTKDETGQL---IGHFNDLVQQL------ 133
Cdd:COG4192 326 ILLLAIALLSLLlavlinYFYVRRRLVKRLNALSDAMAAIAAGDLDVPIPVDGNDEIGRIarlLRVFRDQAIEKtqelet 405
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 134 -----KVNEQHRQKVISDL----------------SHEFRTPLSNLNGYL----KALCNGvvdGDVKLYQSLYDESQRIT 188
Cdd:COG4192 406 eieerKRIEKNLRQTQDELiqaakmavvgqtmtslAHELNQPLNAMSMYLfsakKALEQE---NYAQLPTSLDKIEGLIE 482
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 189 SMVKQLEQLKEWDYISNQTFlekKPVDMQLILTKSVEMFHWTLENAGMSVEFNTEHgVINADSIGISQVIDNLLDNAIQY 268
Cdd:COG4192 483 RMDKIIKSLRQFSRKSDTPL---QPVDLRQVIEQAWELVESRAKPQQITLHIPDDL-MVQGDQVLLEQVLVNLLVNALDA 558
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2225790502 269 YGGEGPIFIKGERLVDRYRVSVAGTGQAIPTenPDRLFERFYRTDtsrsyhSGGTGLGLAISKEIIAHHGGEIGVWS 345
Cdd:COG4192 559 VATQPQISVDLLSNAENLRVAISDNGNGWPL--VDKLFTPFTTTK------EVGLGLGLSICRSIMQQFGGDLYLAS 627
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
256-341 |
1.14e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 66.33 E-value: 1.14e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 256 QVIDNLLDNAIQYYGGEGPIFIKGERLVDRYRVSVAGTGQAIPTENPDRLFERFYrtDTSRSyHSG--GTGLGLAISKEI 333
Cdd:cd16945 7 QAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFY--SLPRP-HSGqkSTGLGLAFVQEV 83
|
....*...
gi 2225790502 334 IAHHGGEI 341
Cdd:cd16945 84 AQLHGGRI 91
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
60-142 |
1.41e-13 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 72.07 E-value: 1.41e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 60 AVLFQYLWFFSIGAIVIGSLIHFYITRKLIEPIKKLIESTKRMKTGHYPGPIDVKTKDETGQLIGHFNDLVQQLKVNEQH 139
Cdd:COG2770 208 LAALLLLLLLALLALLLALLLALLLARRITRPLRRLAEAARRIAAGDLDVRIPVSRKDEIGELARAFNRMADSLRESIEE 287
|
...
gi 2225790502 140 RQK 142
Cdd:COG2770 288 AEE 290
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
212-345 |
2.86e-13 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 70.86 E-value: 2.86e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 212 KPVDMQLILTKSVEMFHWTL-ENAGMSVEFNTEHGVINADSIGISQVIDNLLDNAIQYYGGEGPIFIK------------ 278
Cdd:PRK13837 518 KPFDLSELVTEIAPLLRVSLpPGVELDFDQDQEPAVVEGNPAELQQVLMNLCSNAAQAMDGAGRVDISlsraklrapkvl 597
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 279 --GERLVDRY-RVSVAGTGQAIPTENPDRLFERFYrtdTSRSyhsGGTGLGLAISKEIIAHHGGEIGVWS 345
Cdd:PRK13837 598 shGVLPPGRYvLLRVSDTGAGIDEAVLPHIFEPFF---TTRA---GGTGLGLATVHGIVSAHAGYIDVQS 661
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
67-338 |
6.54e-13 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 69.29 E-value: 6.54e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 67 WFFSIGAIVIgsLIHFYITRKLiEPIKKLiESTKRMKTGHYPGPIDV-KTKDETGQLIGHFNDLVQQLKVNEQHRQKVIS 145
Cdd:PRK10337 167 WLVALPIMLI--ILMVLLGREL-APLKKL-ALALRMRDPDSETPLNAtGVPSEVRPLVEALNQLFARTHAMMVRERRFTS 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 146 DLSHEFRTPLSNLNgylkalcngvVDGDV------------KLYQSLYDESQRITSMVKQLEQLKEWDYISNQTflEKKP 213
Cdd:PRK10337 243 DAAHELRSPLAALK----------VQTEVaqlsdddpqarkKALLQLHAGIDRATRLVDQLLTLSRLDSLDNLQ--DVAE 310
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 214 VDMQLILTKSV-EMFHwTLENAGMSVEFNTE-HGVI-NADSIGISQVIDNLLDNAIQYYGGEGPIFIkgeRLVDRyRVSV 290
Cdd:PRK10337 311 IPLEDLLQSAVmDIYH-TAQQAGIDVRLTLNaHPVIrTGQPLLLSLLVRNLLDNAIRYSPQGSVVDV---TLNAR-NFTV 385
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 2225790502 291 AGTGQAIPTENPDRLFERFYRTDTSrsyHSGGTGLGLAISKEIIAHHG 338
Cdd:PRK10337 386 RDNGPGVTPEALARIGERFYRPPGQ---EATGSGLGLSIVRRIAKLHG 430
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
254-343 |
7.72e-13 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 64.44 E-value: 7.72e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 254 ISQVIDNLLDNAIQYYGGEGPIFIKGERL-VDRYRVSVAGTGQAIPTENPDRLFERFYRTDTSRSYHSGGTGLGLAISKE 332
Cdd:cd16925 5 YERVVLNLLSNAFKFTPDGGRIRCILEKFrLNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLSIVKE 84
|
90
....*....|.
gi 2225790502 333 IIAHHGGEIGV 343
Cdd:cd16925 85 FVELHGGTVTV 95
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
117-358 |
7.76e-13 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 69.67 E-value: 7.76e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 117 DETGQLIGHFNDLVQQLkvNEQHRQ---KV------------------------ISDLSHEFRTPLSNLNGYLKALCNGV 169
Cdd:PRK15347 350 DELGSIAKAYNQLLDTL--NEQYDTlenKVaertqalaeakqraeqankrksehLTTISHEIRTPLNGVLGALELLQNTP 427
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 170 VD------GDVKLYQSLY---------DESqRITS--MVKQLEQ---LKEWDY----ISNQTFleKKPVDMQLILTKSVE 225
Cdd:PRK15347 428 LTaeqmdlADTARQCTLSllaiinnllDFS-RIESgqMTLSLEEtalLPLLDQamltIQGPAQ--SKSLTLRTFVGAHVP 504
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 226 MfhwtlenagmsvEFNTehgvinaDSIGISQVIDNLLDNAIQYyGGEGPIFIKGERLVDRYRVSVAGTGQAIPTENPDRL 305
Cdd:PRK15347 505 L------------YLHL-------DSLRLRQILVNLLGNAVKF-TETGGIRLRVKRHEQQLCFTVEDTGCGIDIQQQQQI 564
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 2225790502 306 FERFYRTDTsrsyHSGGTGLGLAISKEIIAHHGGEIGVWSDRDFHT-FWFTLPL 358
Cdd:PRK15347 565 FTPFYQADT----HSQGTGLGLTIASSLAKMMGGELTLFSTPGVGScFSLVLPL 614
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
254-357 |
1.05e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 63.57 E-value: 1.05e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 254 ISQVIDNLLDNAIQYYGGEGP----IFIKGERLVDRY-RVSVAGTGQAIPTENPDRLFERFYRTDTSrsyhsgGTGLGLA 328
Cdd:cd16920 1 IQQVLINLVRNGIEAMSEGGCerreLTIRTSPADDRAvTISVKDTGPGIAEEVAGQLFDPFYTTKSE------GLGMGLS 74
|
90 100 110
....*....|....*....|....*....|
gi 2225790502 329 ISKEIIAHHGGEIGVWSDRD-FHTFWFTLP 357
Cdd:cd16920 75 ICRSIIEAHGGRLSVESPAGgGATFQFTLP 104
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
121-358 |
2.28e-12 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 68.61 E-value: 2.28e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 121 QLIGHFNDLVQQLKVNEQH-------RQKVISDLSHEFRTPLSNLNGYLKALCNGVVDGD--VKLYQSLYDESQRITSMV 191
Cdd:PRK09959 686 QDITETRDLIHALEVERNKainatvaKSQFLATMSHEIRTPISSIMGFLELLSGSGLSKEqrVEAISLAYATGQSLLGLI 765
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 192 KQLEQLKEWDyiSNQTFLEKKPVDMQLILTKSVEMFHWTLENAGMSVEFNT---EHGVINADSIGISQVIDNLLDNAIQy 268
Cdd:PRK09959 766 GEILDVDKIE--SGNYQLQPQWVDIPTLVQNTCHSFGAIAASKSIALSCSStfpDHYLVKIDPQAFKQVLSNLLSNALK- 842
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 269 YGGEGPIFIKGE--RLVDRY---RVSVAGTGQAIPTENPDRLFERFYRTDTSRsyHSGGTGLGLAISKEIIAHHGGEIGV 343
Cdd:PRK09959 843 FTTEGAVKITTSlgHIDDNHaviKMTIMDSGSGLSQEEQQQLFKRYSQTSAGR--QQTGSGLGLMICKELIKNMQGDLSL 920
|
250
....*....|....*.
gi 2225790502 344 WSDRDF-HTFWFTLPL 358
Cdd:PRK09959 921 ESHPGIgTTFTITIPV 936
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
238-345 |
2.73e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 63.30 E-value: 2.73e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 238 VEFNTEHGVI--NADSIGISQVIDNLLDNAIQYyGGEGPIFikGERLVDRYR---VSVAGTGQAIPTENPDRLFERFYRT 312
Cdd:cd16947 3 VEINIPDRPIyaNANTEALQRILKNLISNAIKY-GSDGKFL--GMTLREDEKhvyIDIWDKGKGISETEKDHVFERLYTL 79
|
90 100 110
....*....|....*....|....*....|...
gi 2225790502 313 DTSRSYHSGGTGLGLAISKEIIAHHGGEIGVWS 345
Cdd:cd16947 80 EDSRNSAKQGNGLGLTITKRLAESMGGSIYVNS 112
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
254-358 |
4.08e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 62.06 E-value: 4.08e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 254 ISQVIDNLLDNAIQYYGGEGPI--FIKGERLvdryRVSVAGTGQAIPTENPDRLFERFYRTDTSRSYHSGGTGLGLAISK 331
Cdd:cd16939 1 MARALDNLLRNALRYAHRTVRIalLVSGGRL----TLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVH 76
|
90 100
....*....|....*....|....*...
gi 2225790502 332 EIIAHHGGEIGVW-SDRDFHTFWFTLPL 358
Cdd:cd16939 77 RVALWHGGHVECDdSELGGACFRLTWPR 104
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
120-358 |
1.07e-11 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 65.64 E-value: 1.07e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 120 GQLIGH---FNDLVQQLKVNEQ-HRQKVISD----LSHEFRTPLSNLNGYLKalcNGVVDGDVKLYQSLYDESQRITSMV 191
Cdd:COG3290 161 GRVVGAvatFRDRTELERLEEElEGVKELAEalraQRHDFRNHLHTISGLLQ---LGEYDEALEYIDEISEELQELIDSL 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 192 KqleqlkewDYISNqtflekkPVDMQLILTKSVEMfhwTLENAGMSVEFNTEHGVINADSIGISQVIDNLLDNAI----Q 267
Cdd:COG3290 238 L--------SRIGN-------PVLAALLLGKAARA---RERGIDLTIDIDSDLPDLPLSDTDLVTILGNLLDNAIeaveK 299
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 268 YYGGEGPIFIKGERLVDRYRVSVAGTGQAIPTENPDRLFERFYRTDTSrsyhsGGTGLGLAISKEIIAHHGGEIGVWSDR 347
Cdd:COG3290 300 LPEEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGFSTKLG-----EGRGLGLALVKQIVEKYGGTIEVESEE 374
|
250
....*....|..
gi 2225790502 348 DFHT-FWFTLPL 358
Cdd:COG3290 375 GEGTvFTVRLPK 386
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
250-348 |
4.24e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 59.47 E-value: 4.24e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 250 DSIGISQVIDNLLDNAIQYYGG------EGPIFIKGERlVDRYRVSVAGTGQAIPTENPDRLFERfYRTDTSRsyhsgGT 323
Cdd:cd16944 1 DTTQISQVLTNILKNAAEAIEGrpsdvgEVRIRVEADQ-DGRIVLIVCDNGKGFPREMRHRATEP-YVTTRPK-----GT 73
|
90 100
....*....|....*....|....*
gi 2225790502 324 GLGLAISKEIIAHHGGEIGVwSDRD 348
Cdd:cd16944 74 GLGLAIVKKIMEEHGGRISL-SNRE 97
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
144-358 |
7.62e-11 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 63.42 E-value: 7.62e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 144 ISDLSHEFRTPLsnlngylkalcNGVVDgdvkLYQSLYDEsqRITSmvKQLEQLK-----------------EWDYIS-N 205
Cdd:PRK11091 287 ISTISHELRTPL-----------NGIVG----LSRILLDT--ELTA--EQRKYLKtihvsaitlgnifndiiDMDKMErR 347
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 206 QTFLEKKPVDMQLILTKsvemfhwtLEN-AGMSVE-----FNTE------HGVInADSIGISQVIDNLLDNAIQYyGGEG 273
Cdd:PRK11091 348 KLQLDNQPIDFTDFLAD--------LENlSGLQAEqkglrFDLEpllplpHKVI-TDGTRLRQILWNLISNAVKF-TQQG 417
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 274 PIFIKGERLV-DRYRVSVAGTGQAIPTENPDRLFERFYR-TDTSRSYHSGGTGLGLAISKEIIAHHGGEIGVWSDRDF-H 350
Cdd:PRK11091 418 GVTVRVRYEEgDMLTFEVEDSGIGIPEDELDKIFAMYYQvKDSHGGKPATGTGIGLAVSKRLAQAMGGDITVTSEEGKgS 497
|
....*...
gi 2225790502 351 TFWFTLPL 358
Cdd:PRK11091 498 CFTLTIHA 505
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
60-138 |
7.77e-10 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 59.90 E-value: 7.77e-10
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2225790502 60 AVLFQYLWFFSIGAIVIGSLIHFYITRKLIEPIKKLIESTKRMKTGHYPGPIDVKTKDETGQLIGHFNDLVQQLKVNEQ 138
Cdd:COG3850 114 AINRKLALLRLLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGDFDARVPVSGRDELGTLARAFNRMADELQELYA 192
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
247-360 |
1.24e-09 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 59.60 E-value: 1.24e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 247 INADSIGISQVIDNLLDNAIQYyGGEGPIFIKGERLVDRYRVSVAGTGQAIPTENPDRLFERFYRTDTSRSYHSGGTGLG 326
Cdd:PRK10841 556 LNGDPMRLQQVISNLLSNAIKF-TDTGCIVLHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLG 634
|
90 100 110
....*....|....*....|....*....|....*
gi 2225790502 327 LAISKEIIAHHGGEIGVWSDRDFHT-FWFTLPLWK 360
Cdd:PRK10841 635 LAICEKLINMMDGDISVDSEPGMGSqFTIRIPLYG 669
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
138-358 |
1.36e-09 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 58.94 E-value: 1.36e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 138 QHRQKV-----ISDLSHEFRTPLSNLNGYLKALCNGVVDGDVKLY-QSLYDESQRITSMVKQLeqlkewdyisnqtflek 211
Cdd:PRK11073 123 QHAQQVaardlVRGLAHEIKNPLGGLRGAAQLLSKALPDPALTEYtKVIIEQADRLRNLVDRL----------------- 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 212 kpVDMQLILTKSVEMFHWTLENAGMSVEFNTEHGV------------INADSIGISQVIDNLLDNAIQYYGGEG------ 273
Cdd:PRK11073 186 --LGPQRPGTHVTESIHKVAERVVQLVSLELPDNVrlirdydpslpeLAHDPDQIEQVLLNIVRNALQALGPEGgtitlr 263
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 274 -----PIFIKGERLVDRYRVSVAGTGQAIPTENPDRLFerfYRTDTSRSyhsGGTGLGLAISKEIIAHHGGEIGVWSDRD 348
Cdd:PRK11073 264 trtafQLTLHGERYRLAARIDIEDNGPGIPPHLQDTLF---YPMVSGRE---GGTGLGLSIARNLIDQHSGKIEFTSWPG 337
|
250
....*....|
gi 2225790502 349 FHTFWFTLPL 358
Cdd:PRK11073 338 HTEFSVYLPI 347
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
254-357 |
2.10e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 54.33 E-value: 2.10e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 254 ISQVIDNLLDNAIQYYGGE-GPIFIK------------GERLVdrYRVSVAGTGQAIPTENPDRLFERFYrtdTSRSyhs 320
Cdd:cd16918 1 LIQVFLNLVRNAAQALAGSgGEIILRtrtqrqvtlghpRHRLA--LRVSVIDNGPGIPPDLQDTIFYPMV---SGRE--- 72
|
90 100 110
....*....|....*....|....*....|....*...
gi 2225790502 321 GGTGLGLAISKEIIAHHGGEIGVWSdRDFHT-FWFTLP 357
Cdd:cd16918 73 NGTGLGLAIAQNIVSQHGGVIECDS-QPGHTvFSVSLP 109
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
140-197 |
3.37e-09 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 52.60 E-value: 3.37e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 2225790502 140 RQKVISDLSHEFRTPLSNLNGYLKALCNGVVDGDVKLY-QSLYDESQRITSMVKQLEQL 197
Cdd:pfam00512 2 KSEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQREYlETILRSAERLLRLINDLLDL 60
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
257-357 |
4.91e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 53.44 E-value: 4.91e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 257 VIDNLLDNAIQYYGGEGPIFIKGERLVDRYRVSVAGTGQAIPTENPDRLFERFYrTDTSRSYHSGGTGLGLAISKEIIAH 336
Cdd:cd16948 9 IIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGF-TGENGRNFQESTGMGLYLVKKLCDK 87
|
90 100
....*....|....*....|..
gi 2225790502 337 HGGEIGVWSD-RDFHTFWFTLP 357
Cdd:cd16948 88 LGHKIDVESEvGEGTTFTITFP 109
|
|
| HAMP |
pfam00672 |
HAMP domain; |
84-134 |
7.22e-09 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 51.09 E-value: 7.22e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 2225790502 84 ITRKLIEPIKKLIESTKRMKTGHYPGPIDVKTKDETGQLIGHFNDLVQQLK 134
Cdd:pfam00672 2 LARRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERLR 52
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
89-133 |
1.18e-08 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 50.52 E-value: 1.18e-08
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 2225790502 89 IEPIKKLIESTKRMKTGHYPGPIDVKTKDETGQLIGHFNDLVQQL 133
Cdd:cd06225 1 TRPLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
17-134 |
5.22e-08 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 54.26 E-value: 5.22e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 17 LSITNMIVITAFILLSGWSIYNAACSLADGLGSMNEQKQEKFNAVLFQYLWFFSIGAIVIGSLIHFYITRKLIEPIKKLI 96
Cdd:COG0840 135 AALLALAALALALLALALLAAAAAAAAALAALLEAAALALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELL 214
|
90 100 110
....*....|....*....|....*....|....*...
gi 2225790502 97 ESTKRMKTGHYPGPIDVKTKDETGQLIGHFNDLVQQLK 134
Cdd:COG0840 215 EVLERIAEGDLTVRIDVDSKDEIGQLADAFNRMIENLR 252
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
256-341 |
7.48e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 50.71 E-value: 7.48e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 256 QVIDNLLDNAIQYygGEGPIFIKGERLVDRYRVSVAGTGQAIPTENPDRLFERFYRTDTSRSyhsgGTGLGLAISKEIIA 335
Cdd:cd16954 40 ELLGNLLDNACKW--CLEFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQRLDEQRP----GQGLGLAIAKEIVE 113
|
....*.
gi 2225790502 336 HHGGEI 341
Cdd:cd16954 114 QYGGEL 119
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
137-197 |
1.13e-07 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 48.36 E-value: 1.13e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2225790502 137 EQHRQKVISDLSHEFRTPLSNLNGYLKALCNGVVDGDV--KLYQSLYDESQRITSMVKQLEQL 197
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEqrEYLERIREEAERLLRLINDLLDL 63
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
71-340 |
1.13e-07 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 53.05 E-value: 1.13e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 71 IGAIVIGSLIHFYIT--------RKLIEPIKKL-IESTKRMKTGHYPGPIDVKTkDETGQLIGHFNDLVQQLKVN-EQHR 140
Cdd:PRK10755 60 VASLLVPSLVMVSLTllicfqavRWITRPLAELqKELEARTADNLTPIAIHSST-LEIEAVTSALNQLVSRLTSTlDQER 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 141 QkVISDLSHEFRTPLSNLNGYLKALC-NGVVDGDVKLyqslydesQRITSMVKQLEQLKEWDYISNQ---------TFLE 210
Cdd:PRK10755 139 L-FTADVAHELRTPLAGIRLHLELLEkQHHIDVAPLI--------ARLDQMMHTVEQLLQLARAGQSfssghyqtvKLLE 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 211 KKPVDMQLILTKSVEMFHWTLEnagmsVEFNTEHGVINADSIGISQVIDNLLDNAIQYYGGEGPIFIKGERLVDRYRVSV 290
Cdd:PRK10755 210 DVILPSQDELSEMLEQRQQTLL-----LPESAADITVQGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDGGAVLAV 284
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 2225790502 291 AGTGQAIPTENPDRLFERFYRTDTSrsYhsGGTGLGLAISKEIIAHHGGE 340
Cdd:PRK10755 285 EDEGPGIDESKCGELSKAFVRMDSR--Y--GGIGLGLSIVSRITQLHHGQ 330
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
86-134 |
1.15e-07 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 48.01 E-value: 1.15e-07
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 2225790502 86 RKLIEPIKKLIESTKRMKTGHYPGPIDVKTKDETGQLIGHFNDLVQQLK 134
Cdd:smart00304 1 RRLLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLE 49
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
140-197 |
1.32e-07 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 47.95 E-value: 1.32e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 2225790502 140 RQKVISDLSHEFRTPLSNLNGYLKALCNGVVDGDVKLY-QSLYDESQRITSMVKQLEQL 197
Cdd:smart00388 2 KREFLANLSHELRTPLTAIRGYLELLLDTELSEEQREYlETILREAERLLRLINDLLDL 60
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
13-142 |
3.13e-07 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 51.94 E-value: 3.13e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 13 FLWRLSITNMIVITAFILLSGWSIYNAACSLADGLGSMNEQKQEKFNAVLFQ---YLWFFSIGAIVIGSLIHFYITRKLI 89
Cdd:COG2972 103 LALILLLALLLLLSILLLILGLLLIILLLLSLLGWTLVSLIPKSELFRGLFSlrrLILLIILLLLLLALLLSYLLSRSIT 182
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 2225790502 90 EPIKKLIESTKRMKTGHYpGPIDVKTKDETGQLIGHFNDLVQQLKVNEQHRQK 142
Cdd:COG2972 183 RPIKRLKKAMKKVEKGDL-VRLEVSGNDEIGILARSFNEMVERIKELIEEVYE 234
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
84-345 |
5.43e-07 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 51.44 E-value: 5.43e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 84 ITRKLIEPIKKLIESTKRMKTGHYPGPI----DVKTKDETGQLIGHFNDLVQQLKVNEQ-------------------HR 140
Cdd:PRK11466 352 VYRSVTRPLAEQTQALQRLLDGDIDSPFpetaGVRELDTIGRLMDAFRSNVHALNRHREqlaaqvkartaelqelvieHR 431
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 141 Q-------------KVISDLSHEFRTPLSNLNGYLKALcngvvdGDVKLYQSLYDESQRIT----SMVKQLEQLKEWDYI 203
Cdd:PRK11466 432 QaraeaekasqaksAFLAAMSHEIRTPLYGILGTAQLL------ADNPALNAQRDDLRAITdsgeSLLTILNDILDYSAI 505
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 204 ---SNQTFLEKKPVDMQLILTKSVEMFHWTLENAGMSVEFNTEHGV---INADSIGISQVIDNLLDNAIQYyGGEGPIFI 277
Cdd:PRK11466 506 eagGKNVSVSDEPFEPRPLLESTLQLMSGRVKGRPIRLATDIADDLptaLMGDPRRIRQVITNLLSNALRF-TDEGSIVL 584
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2225790502 278 KGERLVDRYRVSVAGTGQAIPTENPDRLFERFYRTDTSRsyhsGGTGLGLAISKEIIAHHGGEIGVWS 345
Cdd:PRK11466 585 RSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQVSGKR----GGTGLGLTISSRLAQAMGGELSATS 648
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
254-341 |
1.05e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 46.69 E-value: 1.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 254 ISQVIDNLLDNAIQYYGGEGPIFIKGERLVDRYRVSVAGTGQAIPTENPDRLFERFYRTDTSRsyHSGG-TGLGLAISKE 332
Cdd:cd16975 5 LSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSR--RSGGhYGMGLYIAKN 82
|
....*....
gi 2225790502 333 IIAHHGGEI 341
Cdd:cd16975 83 LVEKHGGSL 91
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
257-357 |
2.42e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 42.66 E-value: 2.42e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 257 VIDNLLDNAIQYYGGEGP------IFIKGERlvDRYRVSVAGTGQAIPTENPDRLFERFYRTDTSrsyhsGGTGLGLAIS 330
Cdd:cd16915 4 IVGNLIDNALDALAATGApnkqveVFLRDEG--DDLVIEVRDTGPGIAPELRDKVFERGVSTKGQ-----GERGIGLALV 76
|
90 100
....*....|....*....|....*...
gi 2225790502 331 KEIIAHHGGEIGVWSDRDFHT-FWFTLP 357
Cdd:cd16915 77 RQSVERLGGSITVESEPGGGTtFSIRIP 104
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
256-341 |
5.36e-05 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 45.01 E-value: 5.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 256 QVIDNLLDNAIQY----------YGGEGPIFIkgerlvdryrvsVAGTGQAIPTENPDRLFERFYRTDTSRSyhsgGTGL 325
Cdd:PRK10815 381 EVMGNVLDNACKYclefveisarQTDEHLHIV------------VEDDGPGIPESKRELIFDRGQRADTLRP----GQGL 444
|
90
....*....|....*.
gi 2225790502 326 GLAISKEIIAHHGGEI 341
Cdd:PRK10815 445 GLSVAREITEQYEGKI 460
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
231-359 |
1.98e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 40.44 E-value: 1.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 231 LENAGMSVEFNTEHGVINADSIGISQVIDNLLDNAIQYYGGEGPifikGERLVdryrVSVAGTGQAIPTENPDRLFERFY 310
Cdd:cd16919 1 LELAILNLAVNARDAMPEGGRLTIETSNQRVDADYALNYRDLIP----GNYVC----LEVSDTGSGMPAEVLRRAFEPFF 72
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 2225790502 311 RTDTSRSyhsgGTGLGLAISKEIIAHHGGEIGVWSDRDFHTfwfTLPLW 359
Cdd:cd16919 73 TTKEVGK----GTGLGLSMVYGFVKQSGGHLRIYSEPGVGT---TVRIY 114
|
|
| PRK15041 |
PRK15041 |
methyl-accepting chemotaxis protein; |
56-122 |
1.77e-03 |
|
methyl-accepting chemotaxis protein;
Pssm-ID: 185001 [Multi-domain] Cd Length: 554 Bit Score: 40.32 E-value: 1.77e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 56 EKFNAVLFQYLWFFSIGAIVIGSLI---HFYITRKLIEPIKKLIESTKRMKTGHYPGPIDVKTKDETGQL 122
Cdd:PRK15041 183 SDNNASYSQAMWILVGVMIVVLAVIfavWFGIKASLVAPMNRLIDSIRHIAGGDLVKPIEVDGSNEMGQL 252
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
257-357 |
5.09e-03 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 38.74 E-value: 5.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225790502 257 VIDNLLDNAIQYYGGEGpifiKGERLVD-RYR-----VSVAGTGQAIPTENPDRLFERFYRTDTSrsyhsgGTGLGLAIS 330
Cdd:PRK11086 437 ILGNLIENALEAVGGEE----GGEISVSlHYRngwlhCEVSDDGPGIAPDEIDAIFDKGYSTKGS------NRGVGLYLV 506
|
90 100
....*....|....*....|....*...
gi 2225790502 331 KEIIAHHGGEIGVWSDRD-FHTFWFTLP 357
Cdd:PRK11086 507 KQSVENLGGSIAVESEPGvGTQFFVQIP 534
|
|
| |
