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Conserved domains on  [gi|2226885514|ref|WP_246568188|]
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RNA methyltransferase [Polymorphospora rubra]

Protein Classification

TrmH family RNA methyltransferase( domain architecture ID 11426248)

TrmH family RNA methyltransferase catalyzes the methylation of rRNA or tRNA at specific sites in a S-adenosyl-L-methionine (SAM)-dependent manner

CATH:  3.40.1280.10
EC:  2.1.1.-
Gene Ontology:  GO:0008173|GO:0032259|GO:0003723|GO:1904047|GO:0006396
PubMed:  11763972|18029778|17338813|30457841|8265370

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SpoU COG0566
tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA ...
 19-262 2.38e-70

tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA G18 (ribose-2'-O)-methylase SpoU is part of the Pathway/BioSystem: tRNA modification


:

Pssm-ID: 440332 [Multi-domain]  Cd Length: 265  Bit Score: 217.76  E-value: 2.38e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226885514  19 ITDPDDERIGDYRALTDVELRTRweppHGLFIAEGELVLRRALRAGYRPRSYLVDAKRVEQLGD------TGDAPVYAAS 92
Cdd:COG0566     1 MTSPSNPRVKDLRKLRDKKYREE----EGLFLAEGRHAVEEALKAGREIEELLVTEGALDRLAEllalakAAGIPVYEVS 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226885514  93 QDVLERATGFHVHRGMLASFHRRELPTAAEVLA---TARRVAVLEDVNNHTNLGAVFRGAAALGIDGVLLSPSCADPLYR 169
Cdd:COG0566    77 REVLDKLSGTETHQGVLAVVRPPEYADLEDLLAeagEPPLLLVLDGVQDPGNLGAILRSAAAFGVDGVILPKRRADPYNP 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226885514 170 RSVRVSMGEVFAVPYATLTPWPDGLEQVRAAGFTVLAMTPAADAvPIQrlTAEQRARAALLLGAEGPGLSRQALAASDVR 249
Cdd:COG0566   157 KVVRASAGALFHVPVARVTNLADALEELKEAGFWVVGTDLDGEA-SLY--EVDLPGPVALVLGNEGKGLSRLVLEACDEL 233

                         250
                  ....*....|...
gi 2226885514 250 VSIPMRRGVDSLN 262
Cdd:COG0566   234 VRIPMAGGVESLN 246
 
Name Accession Description Interval E-value
SpoU COG0566
tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA ...
 19-262 2.38e-70

tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA G18 (ribose-2'-O)-methylase SpoU is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440332 [Multi-domain]  Cd Length: 265  Bit Score: 217.76  E-value: 2.38e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226885514  19 ITDPDDERIGDYRALTDVELRTRweppHGLFIAEGELVLRRALRAGYRPRSYLVDAKRVEQLGD------TGDAPVYAAS 92
Cdd:COG0566     1 MTSPSNPRVKDLRKLRDKKYREE----EGLFLAEGRHAVEEALKAGREIEELLVTEGALDRLAEllalakAAGIPVYEVS 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226885514  93 QDVLERATGFHVHRGMLASFHRRELPTAAEVLA---TARRVAVLEDVNNHTNLGAVFRGAAALGIDGVLLSPSCADPLYR 169
Cdd:COG0566    77 REVLDKLSGTETHQGVLAVVRPPEYADLEDLLAeagEPPLLLVLDGVQDPGNLGAILRSAAAFGVDGVILPKRRADPYNP 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226885514 170 RSVRVSMGEVFAVPYATLTPWPDGLEQVRAAGFTVLAMTPAADAvPIQrlTAEQRARAALLLGAEGPGLSRQALAASDVR 249
Cdd:COG0566   157 KVVRASAGALFHVPVARVTNLADALEELKEAGFWVVGTDLDGEA-SLY--EVDLPGPVALVLGNEGKGLSRLVLEACDEL 233

                         250
                  ....*....|...
gi 2226885514 250 VSIPMRRGVDSLN 262
Cdd:COG0566   234 VRIPMAGGVESLN 246
SpoU-like_rRNA-MTase cd18095
SAM-dependent rRNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes ...
 129-262 8.12e-39

SAM-dependent rRNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349968  Cd Length: 143  Bit Score: 132.94  E-value: 8.12e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226885514 129 RVAVLEDVNNHTNLGAVFRGAAALGIDGVLLSPSCADPLYRRSVRVSMGEVFAVPYATLTPWPDGLEQVRAAGFTVLAMT 208
Cdd:cd18095     1 LVLVLDGVQDPGNLGTIIRTAAAFGVDGVILSKGTVDPYNPKVVRASMGALFRLPIIRVDDLEELLEELKEAGYKVVAAD 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2226885514 209 PAADAVPIQrltAEQRARAALLLGAEGPGLSRQALAASDVRVSIPMRRGVDSLN 262
Cdd:cd18095    81 LDGGSSLYD---LDLPKPVALVLGNEGNGLSDELLELCDKRVTIPMSGGVESLN 131
SpoU_methylase pfam00588
SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.
 130-263 1.26e-32

SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.


Pssm-ID: 425768  Cd Length: 142  Bit Score: 116.86  E-value: 1.26e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226885514 130 VAVLEDVNNHTNLGAVFRGAAALGIDGVLL-SPSCADPLYRRSVRVSMGEVFAVPYATLTPWPDGLEQVRAAGFTVLAMT 208
Cdd:pfam00588   3 VVVLDNIQDPGNLGAIIRTAAAFGADGLILvEPRSADPYNPKAIRASAGALFHLPLVVVDNLEEALKDLKEAGYAVVATS 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2226885514 209 PAADAVPiqrlTAEQRARAALLLGAEGPGLSRQALAASDVRVSIPMRRGVDSLNV 263
Cdd:pfam00588  83 LGGKSLY----EIDFPKKVALVFGNEGTGLSNEVLELCDRLVRIPMSGDVESLNV 133
rRNA_methyl_3 TIGR00186
rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases ...
 132-262 8.25e-21

rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 129290 [Multi-domain]  Cd Length: 237  Bit Score: 88.55  E-value: 8.25e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226885514 132 VLEDVNNHTNLGAVFRGAAALGIDGVLLSPSCADPLYRRSVRVSMGEVFAVPYATLTPWPDGLEQVRAAGFTVLAMTPAA 211
Cdd:TIGR00186  94 ILDEITDPHNLGAILRTAEAFGVDGVILPKRRSAPLNSTVVKTSSGAVEYVPLARVTNLSRTITKLKESGFWTVGTDLDA 173

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2226885514 212 DAVPIQRLTaeqRARAALLLGAEGPGLSRQALAASDVRVSIPMRRGVDSLN 262
Cdd:TIGR00186 174 QDTLYQVKL---TKPLALVVGNEGEGVSRLIKENCDFLIKIPMAGKVDSLN 221
PRK10864 PRK10864
putative methyltransferase; Provisional
 94-262 2.52e-14

putative methyltransferase; Provisional


Pssm-ID: 236779 [Multi-domain]  Cd Length: 346  Bit Score: 72.12  E-value: 2.52e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226885514  94 DVLERATGFHVHRGMLASFHRRELPTAAEVLATARR---VAVLEDVNNHTNLGAVFRGAAALGIDGVLLSpscaDPLYRR 170
Cdd:PRK10864  161 AELTKASGTEHHGGVCFLIKKRNGTDVQQWLAQAGAqdcVLALEDVGNPHNLGGIMRSCAHFGVKGVVVQ----DAALLE 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226885514 171 S---VRVSMGEVFAVPYATLTPWPDGLEQVRAAGFTVLAmTPAADAVPIQRltAEQRARAALLLGAEGPGLSRQALAASD 247
Cdd:PRK10864  237 SgaaIRTAEGGAEHVQPITGDSFVDVLDDFRQAGYTIVT-TSSHKGTPLFK--ASLPAKMVLVLGQEYDGLSDAARQQGD 313

                         170
                  ....*....|....*
gi 2226885514 248 VRVSIPMRRGVDSLN 262
Cdd:PRK10864  314 LSVSIDGTGNVESLN 328
 
Name Accession Description Interval E-value
SpoU COG0566
tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA ...
 19-262 2.38e-70

tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA G18 (ribose-2'-O)-methylase SpoU is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440332 [Multi-domain]  Cd Length: 265  Bit Score: 217.76  E-value: 2.38e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226885514  19 ITDPDDERIGDYRALTDVELRTRweppHGLFIAEGELVLRRALRAGYRPRSYLVDAKRVEQLGD------TGDAPVYAAS 92
Cdd:COG0566     1 MTSPSNPRVKDLRKLRDKKYREE----EGLFLAEGRHAVEEALKAGREIEELLVTEGALDRLAEllalakAAGIPVYEVS 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226885514  93 QDVLERATGFHVHRGMLASFHRRELPTAAEVLA---TARRVAVLEDVNNHTNLGAVFRGAAALGIDGVLLSPSCADPLYR 169
Cdd:COG0566    77 REVLDKLSGTETHQGVLAVVRPPEYADLEDLLAeagEPPLLLVLDGVQDPGNLGAILRSAAAFGVDGVILPKRRADPYNP 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226885514 170 RSVRVSMGEVFAVPYATLTPWPDGLEQVRAAGFTVLAMTPAADAvPIQrlTAEQRARAALLLGAEGPGLSRQALAASDVR 249
Cdd:COG0566   157 KVVRASAGALFHVPVARVTNLADALEELKEAGFWVVGTDLDGEA-SLY--EVDLPGPVALVLGNEGKGLSRLVLEACDEL 233

                         250
                  ....*....|...
gi 2226885514 250 VSIPMRRGVDSLN 262
Cdd:COG0566   234 VRIPMAGGVESLN 246
SpoU-like_rRNA-MTase cd18095
SAM-dependent rRNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes ...
 129-262 8.12e-39

SAM-dependent rRNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349968  Cd Length: 143  Bit Score: 132.94  E-value: 8.12e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226885514 129 RVAVLEDVNNHTNLGAVFRGAAALGIDGVLLSPSCADPLYRRSVRVSMGEVFAVPYATLTPWPDGLEQVRAAGFTVLAMT 208
Cdd:cd18095     1 LVLVLDGVQDPGNLGTIIRTAAAFGVDGVILSKGTVDPYNPKVVRASMGALFRLPIIRVDDLEELLEELKEAGYKVVAAD 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2226885514 209 PAADAVPIQrltAEQRARAALLLGAEGPGLSRQALAASDVRVSIPMRRGVDSLN 262
Cdd:cd18095    81 LDGGSSLYD---LDLPKPVALVLGNEGNGLSDELLELCDKRVTIPMSGGVESLN 131
SpoU_methylase pfam00588
SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.
 130-263 1.26e-32

SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.


Pssm-ID: 425768  Cd Length: 142  Bit Score: 116.86  E-value: 1.26e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226885514 130 VAVLEDVNNHTNLGAVFRGAAALGIDGVLL-SPSCADPLYRRSVRVSMGEVFAVPYATLTPWPDGLEQVRAAGFTVLAMT 208
Cdd:pfam00588   3 VVVLDNIQDPGNLGAIIRTAAAFGADGLILvEPRSADPYNPKAIRASAGALFHLPLVVVDNLEEALKDLKEAGYAVVATS 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2226885514 209 PAADAVPiqrlTAEQRARAALLLGAEGPGLSRQALAASDVRVSIPMRRGVDSLNV 263
Cdd:pfam00588  83 LGGKSLY----EIDFPKKVALVFGNEGTGLSNEVLELCDRLVRIPMSGDVESLNV 133
SpoU-like_family cd18082
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase ...
 132-262 2.19e-25

SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349955  Cd Length: 145  Bit Score: 98.07  E-value: 2.19e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226885514 132 VLEDVNNHTNLGAVFRGAAALGIDGVLLSPSCADPLYRRSVRVSMGEVFAVPYATLTPWPDGLEQVRAAGFTVLAMTPAA 211
Cdd:cd18082     3 VLDNIRSPGNIGSIFRTADAFGVEKIYLVGPTADIFDPKAKRTSRGTHFSVPYERVDNFEEYLKSLKEEGYPLIGLELTD 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2226885514 212 DAVPIQRLTAEQRARAALLLGAEGPGLSRQALAASDVRVSIPMRRGVDSLN 262
Cdd:cd18082    83 GSIPLSEFKFKKPKKIALIFGNERSGLSPELLALCDYTVHIPMSGKNSSLN 133
SpoU-like_RNA-MTase cd18104
SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes ...
 130-263 1.44e-22

SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349977  Cd Length: 146  Bit Score: 90.72  E-value: 1.44e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226885514 130 VAVLEDVNNHTNLGAVFRGAAALGIDGVLLSPSCADPLYRRSVRVSMGEVFAVPYATLTPwPDGLEQVRAAGFTVLAMTP 209
Cdd:cd18104     2 ILVLEGLEKPGNLGAILRSADAAGADAVILCDPKTDLFNPNVIRASLGAVFTLPVAEASS-EETLAWLKENKIRILATTP 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2226885514 210 AADavpIQRLTAEQRARAALLLGAEGPGLSRQALAASDVRVSIPMRRGVDSLNV 263
Cdd:cd18104    81 KAE---KLYYEADLRGPIAIVVGSESEGLSEFWLKAADERVRIPMAGQADSLNV 131
rRNA_methyl_3 TIGR00186
rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases ...
 132-262 8.25e-21

rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 129290 [Multi-domain]  Cd Length: 237  Bit Score: 88.55  E-value: 8.25e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226885514 132 VLEDVNNHTNLGAVFRGAAALGIDGVLLSPSCADPLYRRSVRVSMGEVFAVPYATLTPWPDGLEQVRAAGFTVLAMTPAA 211
Cdd:TIGR00186  94 ILDEITDPHNLGAILRTAEAFGVDGVILPKRRSAPLNSTVVKTSSGAVEYVPLARVTNLSRTITKLKESGFWTVGTDLDA 173

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2226885514 212 DAVPIQRLTaeqRARAALLLGAEGPGLSRQALAASDVRVSIPMRRGVDSLN 262
Cdd:TIGR00186 174 QDTLYQVKL---TKPLALVVGNEGEGVSRLIKENCDFLIKIPMAGKVDSLN 221
SpoU-like_TrmH cd18092
SAM-dependent tRNA methylase related to TrmH; TrmH catalyzes the transfer of the methyl group ...
 122-262 7.51e-20

SAM-dependent tRNA methylase related to TrmH; TrmH catalyzes the transfer of the methyl group from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of the ribose of the universally conserved guanosine 18 (G18) position in tRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349965  Cd Length: 162  Bit Score: 84.06  E-value: 7.51e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226885514 122 EVLA--TARRVAVLEDVNNHTNLGAVFRGAAALGIDGV-LLSPSCAdplYRRSVRVSMGevfAVPYATLTPWPD---GLE 195
Cdd:cd18092     8 EVLArrTRDLTVVLENVHDPHNASAVLRTCDAFGVQDVhVIEPKNK---FKKNRGVAMG---ADKWLDVHRHDSteeCLA 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2226885514 196 QVRAAGFTVLAMTPAADAVPIQRLTAEQRAraALLLGAEGPGLSRQALAASDVRVSIPMRRGVDSLN 262
Cdd:cd18092    82 ALKEQGYRIVATSLSPDAVPLDELDYTRPT--ALVFGNEKDGVSEEALAAADERVYIPMYGFVESLN 146
SpoU-like_RlmB cd18103
SAM-dependent rRNA methylase related to RlmB; 23S rRNA-M2G2251-MTase RlmB catalyzes the ...
 141-262 3.00e-19

SAM-dependent rRNA methylase related to RlmB; 23S rRNA-M2G2251-MTase RlmB catalyzes the methylation of guanosine 2251, a modification conserved in the peptidyltransferase domain of 23S rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349976  Cd Length: 143  Bit Score: 81.66  E-value: 3.00e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226885514 141 NLGAVFRGAAALGIDGVLLsPScadplyRRSV-------RVSMGEVFAVPYATLTPWPDGLEQVRAAGFTVLAMTpAADA 213
Cdd:cd18103    13 NLGAIIRSAEAFGVDGVII-PK------RRSApltptvaKASAGALEHLPIARVTNLARALEELKEAGFWIYGAD-GEAE 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2226885514 214 VPIqrLTAEQRARAALLLGAEGPGLSRQALAASDVRVSIPMRRGVDSLN 262
Cdd:cd18103    85 KSL--YDVDLTGPLALVLGSEGKGLRRLVLKNCDFLVKIPMAGKVDSLN 131
SpoU-like_RNA-MTase cd18109
SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes ...
 132-262 2.55e-17

SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349982  Cd Length: 141  Bit Score: 76.42  E-value: 2.55e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226885514 132 VLEDVNNHTNLGAVFRGAAALGIDGVLLSPSCADPLYRRSVRVSMGEVFAVPyATLTPWPDGLEQVRAAGFTVLAMtpaA 211
Cdd:cd18109     4 ALDGIQDPGNLGTIIRTADWFGIRQIICSPDTVDPYNPKVVQASMGSIFRVQ-IHYTDLPALLAELKKAFPVYGAD---L 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2226885514 212 DAVPIQRLTAEQraRAALLLGAEGPGLSRQALAASDVRVSIPMR-RGVDSLN 262
Cdd:cd18109    80 DGENLYEFTLPE--KGILVMGNEGHGISPEVLKLLTHRLTIPRYgKGAESLN 129
SpoU-like_RNMTL1 cd18106
SAM-dependent rRNA methylase related to RNMTL1; RNMTL1 (also known as HC90, MRM3 and RMTL1) ...
 132-262 5.04e-15

SAM-dependent rRNA methylase related to RNMTL1; RNMTL1 (also known as HC90, MRM3 and RMTL1) catalyzes the methylation of 2'-O-ribose residues G1370 to GmG residue of the mitochondrial 16S rRNA. RNMTL1 is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349979  Cd Length: 148  Bit Score: 70.36  E-value: 5.04e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226885514 132 VLEDVNNHTNLGAVFRGAAALGIDGVLLSPSCADPLYRRSVRVSMGEVFAVPYATLTPWPDGLEQVRaAGFTVLamtPAA 211
Cdd:cd18106     4 ICDNIRDPGNLGSILRSAAAAGCSKVLLTKGCVDPWEPKVLRAGAGAHFRLPIYGNLSWDDIPNYLP-DDSKVF---LAD 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2226885514 212 DAVPIQRLTAE--QRARAALLLGAEGPGLSRQA--LAASD--VRVSIPMRRGVDSLN 262
Cdd:cd18106    80 NNLPVQPYDSIdyCSGPIVLVIGGETHGVSPEAykLAHSTggSRVHIPLANGVDSLN 136
PRK10864 PRK10864
putative methyltransferase; Provisional
 94-262 2.52e-14

putative methyltransferase; Provisional


Pssm-ID: 236779 [Multi-domain]  Cd Length: 346  Bit Score: 72.12  E-value: 2.52e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226885514  94 DVLERATGFHVHRGMLASFHRRELPTAAEVLATARR---VAVLEDVNNHTNLGAVFRGAAALGIDGVLLSpscaDPLYRR 170
Cdd:PRK10864  161 AELTKASGTEHHGGVCFLIKKRNGTDVQQWLAQAGAqdcVLALEDVGNPHNLGGIMRSCAHFGVKGVVVQ----DAALLE 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226885514 171 S---VRVSMGEVFAVPYATLTPWPDGLEQVRAAGFTVLAmTPAADAVPIQRltAEQRARAALLLGAEGPGLSRQALAASD 247
Cdd:PRK10864  237 SgaaIRTAEGGAEHVQPITGDSFVDVLDDFRQAGYTIVT-TSSHKGTPLFK--ASLPAKMVLVLGQEYDGLSDAARQQGD 313

                         170
                  ....*....|....*
gi 2226885514 248 VRVSIPMRRGVDSLN 262
Cdd:PRK10864  314 LSVSIDGTGNVESLN 328
SpoU-like_NHR cd18108
Nosiheptide-resistance methyltransferase (NHR); Nosiheptide-resistance methyltransferase (NHR) ...
 130-262 4.14e-14

Nosiheptide-resistance methyltransferase (NHR); Nosiheptide-resistance methyltransferase (NHR) confers resistance to the thiazole antibiotic nosiheptide via catalyzing 2'O-methylation of 23S rRNA at the nucleotide A1067. NHR is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349981  Cd Length: 144  Bit Score: 67.89  E-value: 4.14e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226885514 130 VAVLEDVNNHTNLGAVFRGAAALGIDGVLLSPS-CADPLYRRSVRVSMGEVFAVPyATLTPWPDGLEQVRAAGFTVlaMT 208
Cdd:cd18108     2 VVVLDGVRIVGNIGAIVRTSLALGAAGIVLVDSdLATVADRRLLRASRGYVFSLP-VVLADREEAVAFLRDNDIPL--MT 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2226885514 209 PAADA-VPIQRLTAeQRARAALLLGAEGPGLSRQALAASDVRVSIPMRRGVDSLN 262
Cdd:cd18108    79 LDADGdVPVKELGD-RPDRLALVFGSEKGGPSGLFEEAAAGTVSIPMSSSTESLN 132
SpoU-like_AviRb cd18107
SAM-dependent rRNA methylase related to AviRb; AviRb from Streptomyces viridochromogenes ...
 141-273 2.11e-13

SAM-dependent rRNA methylase related to AviRb; AviRb from Streptomyces viridochromogenes methylates the 2'-O atom of U2479 of the 23S ribosomal RNA. AviRb is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349980  Cd Length: 148  Bit Score: 66.26  E-value: 2.11e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226885514 141 NLGAVFRGAAALGIDGVLLSPSCADPLYRRSVRVSMGEVFAVP------YATLTPWPDGLeQVRAAGFTVLAMTPAADav 214
Cdd:cd18107    13 NLGTIIRSADALGAHGLVVTGHAADVYDPKTIRASTGSLFSLPivrvpsNRELEDWVEAR-KARGTPLQLVGTDEHGD-- 89

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226885514 215 piQRLTAEQRARAALL-LGAEGPGLSRQALAASDVRVSIPMRRGVDSLNVAAAAAVAFWE 273
Cdd:cd18107    90 --HQIADHDFTRPTLLlIGNETAGLSAAWRELCDETVSIPMAGSASSLNAACAASIFLYE 147
SpoU-like cd18097
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase ...
 130-274 1.42e-12

SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349970  Cd Length: 144  Bit Score: 63.74  E-value: 1.42e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226885514 130 VAVLEDVNNHTNLGAVFRGAAALGIDGVLLSPSCADPLYRRSVRVSMGEVFAVPYATltpWPDGLEQV---RAAGFTVLA 206
Cdd:cd18097     2 VVVLDNLRSAHNVGSIFRTADAAGVEKIYLCGYTPTPPHPKVAKTALGAEESVPWEH---FEDTLEAVralKARGYTIIA 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2226885514 207 MTPAADAVPIQRLTAEQRAraALLLGAEGPGLSRQALAASDVRVSIPMRRGVDSLNVAAAAAVAFWEL 274
Cdd:cd18097    79 LETTENSVPLHEARLPRPL--ALVLGNEVRGVSPEVLALCDAVVEIPMFGRKNSLNVAVAAAVALYEL 144
SpoU-like_MRM1 cd18105
SAM-dependent rRNA methylase related to MRM1; MRM1 catalyzes the methylation of 2'-O-ribose ...
 141-262 4.95e-10

SAM-dependent rRNA methylase related to MRM1; MRM1 catalyzes the methylation of 2'-O-ribose residues G1145 to GmG residue of the mitochondrial 16S rRNA. MRM1 is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349978  Cd Length: 158  Bit Score: 57.14  E-value: 4.95e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226885514 141 NLGAVFRGAAALGIDGVLLSPSCADPLYRRSVRVSMG--EVFAVpYATLTPwPDGLEQVRAAGFTVLAMTPAADAVPIQR 218
Cdd:cd18105    13 NLGAILRSAYFLGVDGVVVSSKNSAPLSPVVSKASAGalELMPI-YSVDNL-ASFLKSSKENGWKVVGTSAPPSASSDKK 90

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2226885514 219 L-------TAEQRARAALLLGAEGPGLSRQALAASDVRVSIPMRR-----GVDSLN 262
Cdd:cd18105    91 TipanelsELLLEKPTILVLGNEGRGLRTNIKNLCDYLVSIPGGRsaenpGVDSLN 146
SpoU-like_TRM3-like cd18091
SAM-dependent tRNA methylase related to TRM3; Yeast tRNA (guanosine(18)-2'-O) ...
 136-262 4.08e-09

SAM-dependent tRNA methylase related to TRM3; Yeast tRNA (guanosine(18)-2'-O)-methyltransferase TRM3 catalyzes the formation of 2'-O-methylguanosine at position 18 (Gm18) in various tRNAs. TRM3 is similar to C-terminal domain of TAR (HIV-1) RNA binding protein 1 (TARBP1), a protein binding to TAR, which functions as a RNA regulatory signal by forming a stable stem-loop structure to which transactivator protein Tat binds. The role of TARBP1 is believed to be to disengage RNA polymerase II from TAR during transcriptional elongation. TRM3 and the C-terminal methyltransferase domain of TARBP1 are members of the SPOUT methyltransferase superfamily.


Pssm-ID: 349964  Cd Length: 145  Bit Score: 54.07  E-value: 4.08e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226885514 136 VNNHTNLGAVFRGAAALGIDGVLL-SPSCADPLYRRSVRVSmGEVF----AVPYATLTPWpdgLEQVRAAGFTVLAMTPA 210
Cdd:cd18091     8 IDKPPNLGGLCRTCEIFGVSKLVLpNLAVVEDKQFKALSVS-AEKWlpieEVKPEDLLPY---LKEKKQEGYTIVGLEQT 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2226885514 211 ADAVPIQRLTAeqRARAALLLGAEGPGLSRQALAASDVRVSIPMRRGVDSLN 262
Cdd:cd18091    84 ANSVSLHDFQF--PKKTVLVLGNEKEGIPAELLSLLDVCVEIPQLGVIRSLN 133
SpoU-like cd18096
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase ...
 132-262 2.53e-06

SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349969  Cd Length: 140  Bit Score: 46.05  E-value: 2.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226885514 132 VLEDVNNHTNLGAVFRGAAALGIDGVLLSPScaDPLYRRSVRVSMGEVFAVPYATLtpwPDGLEQVRAAGFTVLAMTPAA 211
Cdd:cd18096     4 VLHNVAKRHNIGTIVRSANAFGVKEVHLVGR--RKFNPFGAMGTDRHVKFRHFDTL---AEAKEYLKERGIRLVGVEIVP 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2226885514 212 DAVPIQrlTAEQRARAALLLGAEGPGLSRQALAASDVRVSIPMR-RGVDSLN 262
Cdd:cd18096    79 GAEPIE--THPFPGDTAFVLGNEGTGLSDEQLAICDGFVYIPQYgSGTASLN 128
PRK11081 PRK11081
tRNA guanosine-2'-O-methyltransferase; Provisional
 133-263 4.33e-06

tRNA guanosine-2'-O-methyltransferase; Provisional


Pssm-ID: 236837 [Multi-domain]  Cd Length: 229  Bit Score: 46.52  E-value: 4.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226885514 133 LEDVNNHTNLGAVFRGAAALGIDGV-LLSPscaDPLYRRSVRVSMGEVFAVPYATLTPWPDGLEQVRAAGFTVLAMTPAA 211
Cdd:PRK11081   24 MEQVHKPHNVSAIIRTADAVGVHEVhAVWP---GSRMRTMGSTAAGSNSWVQVKTHRTIGDAVAHLKGQGMQILATHLSD 100

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2226885514 212 DAVPIQ-----RLTAeqraraaLLLGAEGPGLSRQALAASDVRVSIPMRRGVDSLNV 263
Cdd:PRK11081  101 TAVDFReidytRPTC-------ILMGQEKTGISQEALALADQDIIIPMIGMVQSLNV 150
PRK11181 PRK11181
23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB;
132-262 1.28e-04

23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB;


Pssm-ID: 183021 [Multi-domain]  Cd Length: 244  Bit Score: 42.26  E-value: 1.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226885514 132 VLEDVNNHTNLGAVFRGAAALGIDGVLLSPSCADPLYRRSVRVSMGEVFAVPYATLTPWPDGLEQVRAAGFTVLAMTPAA 211
Cdd:PRK11181   99 ILDGVTDPHNLGACLRSADAAGVHAVIVPKDRSAQLNATAKKVACGAAETVPLIRVTNLARTMRMLQEKNIWIVGTAGEA 178

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2226885514 212 DAVPIQ-RLTAeqraRAALLLGAEGPGLSRQALAASDVRVSIPMRRGVDSLN 262
Cdd:PRK11181  179 DHTLYQsKLTG----PLALVMGAEGEGMRRLTREHCDELISIPMAGSVSSLN 226
SpoU-like cd18098
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase ...
 133-262 1.63e-04

SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349971  Cd Length: 138  Bit Score: 40.71  E-value: 1.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226885514 133 LEDVNNHTNLGAVFRGAAALGIDGVLLSPscADPLYRRSVRVSMGEVFAVPYATLTPWPDGLE-QVRAAGFTVLAMTPAA 211
Cdd:cd18098     5 IENPKTPKNVGTLWRAAGCLGASFVFTIG--ARYKRRKQSTDTSKAWRHIPLFHYDDLEDLAEpLPFGAVLVAVELTEGA 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2226885514 212 DAVPiqrlTAEQRARAALLLGAEGPGLSRQALAASDVRVSIPMRRgvdSLN 262
Cdd:cd18098    83 TPLP----DFKHPDRAVYLLGPEDGGLPQEVLARCHHVVYLPTRG---SLN 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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