NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2233827924|ref|WP_248442329|]
View 

rhombosortase [Pseudoalteromonas sp. 1CM17D]

Protein Classification

rhombosortase( domain architecture ID 10024056)

rhombosortase is a membrane-bound protein that catalyzes regulated intramembrane proteolysis, resulting in the proper response to protein sorting signals

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
rhom_GG_sort TIGR03902
rhomboid family GlyGly-CTERM serine protease; This model describes a rhomboid-like ...
 30-183 1.91e-50

rhomboid family GlyGly-CTERM serine protease; This model describes a rhomboid-like intramembrane serine protease. Its species distribution closely matches model TIGR03501, GlyGly-CTERM, which describes a protein targeting domain analogous to LPXTG and PEP-CTERM. In a number of species (Ralstonia eutropha ,R. metallidurans, R. solanacearum, Marinobacter aquaeolei, etc) with just one GlyGly-CTERM protein (i.e., a dedicated system), the rhombosortase and GlyGly-CTERM genes are adjacent.


:

Pssm-ID: 274845  Cd Length: 154  Bit Score: 160.04  E-value: 1.91e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2233827924  30 NNLLEFNRALIENGEVWRVFTSQFVHANWAHLGLNALGVFLIWLLHGEYTSPARYAFNVCFLALWCGLGVLWFCPAISIY 109
Cdd:TIGR03902   1 SDLLAYDRAAILDGEWWRLLTGHFVHLNWWHLLMNLAGLLLLWALFGRHLRARRLLLLLLLLSLLISLGLLLFLPSLQWY 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2233827924 110 TGLSALLHGVIIWGAVKDITLSLKSGYLLFIGVWIKIIMEQVNGPDASIGQLIDSTVAIDAHLIGAVGGTLLGI 183
Cdd:TIGR03902  81 VGLSGVLHGLFAWGALRDIRYGRRSGWLLLLGVIAKLAWEQLFGASAFTAALIGAPVATEAHLAGAISGLLIAL 154
 
Name Accession Description Interval E-value
rhom_GG_sort TIGR03902
rhomboid family GlyGly-CTERM serine protease; This model describes a rhomboid-like ...
 30-183 1.91e-50

rhomboid family GlyGly-CTERM serine protease; This model describes a rhomboid-like intramembrane serine protease. Its species distribution closely matches model TIGR03501, GlyGly-CTERM, which describes a protein targeting domain analogous to LPXTG and PEP-CTERM. In a number of species (Ralstonia eutropha ,R. metallidurans, R. solanacearum, Marinobacter aquaeolei, etc) with just one GlyGly-CTERM protein (i.e., a dedicated system), the rhombosortase and GlyGly-CTERM genes are adjacent.


Pssm-ID: 274845  Cd Length: 154  Bit Score: 160.04  E-value: 1.91e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2233827924  30 NNLLEFNRALIENGEVWRVFTSQFVHANWAHLGLNALGVFLIWLLHGEYTSPARYAFNVCFLALWCGLGVLWFCPAISIY 109
Cdd:TIGR03902   1 SDLLAYDRAAILDGEWWRLLTGHFVHLNWWHLLMNLAGLLLLWALFGRHLRARRLLLLLLLLSLLISLGLLLFLPSLQWY 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2233827924 110 TGLSALLHGVIIWGAVKDITLSLKSGYLLFIGVWIKIIMEQVNGPDASIGQLIDSTVAIDAHLIGAVGGTLLGI 183
Cdd:TIGR03902  81 VGLSGVLHGLFAWGALRDIRYGRRSGWLLLLGVIAKLAWEQLFGASAFTAALIGAPVATEAHLAGAISGLLIAL 154
GlpG COG0705
Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein ...
 23-186 1.28e-12

Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440469 [Multi-domain]  Cd Length: 189  Bit Score: 63.34  E-value: 1.28e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2233827924  23 VFAAFDLNNLLEFNRALIENGEVWRVFTSQFVHANWAHLGLNALGVFLIWLLHGEYTSPARYAFNVCFLALWCGLGVLWF 102
Cdd:COG0705    21 LLLGGELLNWLALVPARLLLGELWRLLTSMFLHGGFLHLLFNMLALWVFGPLLERRLGSKRFLLLYLLSGLGGGLLQLLF 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2233827924 103 CPAISIYT-GLSALLHGVIIWGAVKDITLSLksgYLLFIGVWIKIIMEQVNGPDASIGQLIDSTVAIDAHLIGAVGGTLL 181
Cdd:COG0705   101 SPGSGYPLvGASGAIFGLLGALLVLGPRRRV---LLLFIPIPALLFLLVWLLLGLLFGLLGGGGIAWEAHLGGLLAGLLL 177


                  ....*
gi 2233827924 182 GIPLA 186
Cdd:COG0705   178 ALLLR 182
Rhomboid pfam01694
Rhomboid family; This family contains integral membrane proteins that are related to ...
 39-185 1.60e-05

Rhomboid family; This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.


Pssm-ID: 426384  Cd Length: 147  Bit Score: 42.98  E-value: 1.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2233827924  39 LIENGEVWRVFTSQFVHANWAHLGLNALGVFLIWLLHGEYTSPARYAFNVCFLALWCGLGVLWFCPAISIYTGLSALLHG 118
Cdd:pfam01694   1 PVQPGQLWRLITSMFLHAGWLHLLFNMLALLFFGGPLERILGSVRFLLLYLLSGIAGSLLSYLFSPLSTPSVGASGAIFG 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2233827924 119 VIiwgavkditlslksGYLLFIGVWIKIIMEQVNGPDASIGQLI----------DSTVAIDAHLIGAVGGTLLGIPL 185
Cdd:pfam01694  81 LL--------------GALLVLGPRNRILLFGLIGALLALLLFIllnlvlgllpGNGVSNLAHLGGLLVGLLLGFIL 143
 
Name Accession Description Interval E-value
rhom_GG_sort TIGR03902
rhomboid family GlyGly-CTERM serine protease; This model describes a rhomboid-like ...
 30-183 1.91e-50

rhomboid family GlyGly-CTERM serine protease; This model describes a rhomboid-like intramembrane serine protease. Its species distribution closely matches model TIGR03501, GlyGly-CTERM, which describes a protein targeting domain analogous to LPXTG and PEP-CTERM. In a number of species (Ralstonia eutropha ,R. metallidurans, R. solanacearum, Marinobacter aquaeolei, etc) with just one GlyGly-CTERM protein (i.e., a dedicated system), the rhombosortase and GlyGly-CTERM genes are adjacent.


Pssm-ID: 274845  Cd Length: 154  Bit Score: 160.04  E-value: 1.91e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2233827924  30 NNLLEFNRALIENGEVWRVFTSQFVHANWAHLGLNALGVFLIWLLHGEYTSPARYAFNVCFLALWCGLGVLWFCPAISIY 109
Cdd:TIGR03902   1 SDLLAYDRAAILDGEWWRLLTGHFVHLNWWHLLMNLAGLLLLWALFGRHLRARRLLLLLLLLSLLISLGLLLFLPSLQWY 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2233827924 110 TGLSALLHGVIIWGAVKDITLSLKSGYLLFIGVWIKIIMEQVNGPDASIGQLIDSTVAIDAHLIGAVGGTLLGI 183
Cdd:TIGR03902  81 VGLSGVLHGLFAWGALRDIRYGRRSGWLLLLGVIAKLAWEQLFGASAFTAALIGAPVATEAHLAGAISGLLIAL 154
GlpG COG0705
Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein ...
 23-186 1.28e-12

Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440469 [Multi-domain]  Cd Length: 189  Bit Score: 63.34  E-value: 1.28e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2233827924  23 VFAAFDLNNLLEFNRALIENGEVWRVFTSQFVHANWAHLGLNALGVFLIWLLHGEYTSPARYAFNVCFLALWCGLGVLWF 102
Cdd:COG0705    21 LLLGGELLNWLALVPARLLLGELWRLLTSMFLHGGFLHLLFNMLALWVFGPLLERRLGSKRFLLLYLLSGLGGGLLQLLF 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2233827924 103 CPAISIYT-GLSALLHGVIIWGAVKDITLSLksgYLLFIGVWIKIIMEQVNGPDASIGQLIDSTVAIDAHLIGAVGGTLL 181
Cdd:COG0705   101 SPGSGYPLvGASGAIFGLLGALLVLGPRRRV---LLLFIPIPALLFLLVWLLLGLLFGLLGGGGIAWEAHLGGLLAGLLL 177


                  ....*
gi 2233827924 182 GIPLA 186
Cdd:COG0705   178 ALLLR 182
Rhomboid pfam01694
Rhomboid family; This family contains integral membrane proteins that are related to ...
 39-185 1.60e-05

Rhomboid family; This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.


Pssm-ID: 426384  Cd Length: 147  Bit Score: 42.98  E-value: 1.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2233827924  39 LIENGEVWRVFTSQFVHANWAHLGLNALGVFLIWLLHGEYTSPARYAFNVCFLALWCGLGVLWFCPAISIYTGLSALLHG 118
Cdd:pfam01694   1 PVQPGQLWRLITSMFLHAGWLHLLFNMLALLFFGGPLERILGSVRFLLLYLLSGIAGSLLSYLFSPLSTPSVGASGAIFG 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2233827924 119 VIiwgavkditlslksGYLLFIGVWIKIIMEQVNGPDASIGQLI----------DSTVAIDAHLIGAVGGTLLGIPL 185
Cdd:pfam01694  81 LL--------------GALLVLGPRNRILLFGLIGALLALLLFIllnlvlgllpGNGVSNLAHLGGLLVGLLLGFIL 143
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH