|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
10-886 |
0e+00 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 600.87 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 10 DALVEGLQREAGGKLTVFLGAAPGVGKTYTMLTRAQEQLRRGVDLVVGLVETHGRADTQALLEGLPQLPLKDVAYHGHAL 89
Cdd:PRK10490 11 DRLLEQTAEPHRGKLKIFFGACAGVGKTYAMLQEAQRLRAQGLDVLVGVVETHGRKETAALLEGLTVLPPKRIHHRGRHI 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 90 QEMDLDAVLARRPALVLVDELAHRNAPGSRHERRWQDVMELLDAGIDVWTTVNIQHLESLNDVVMRITGVRVSETVPDGV 169
Cdd:PRK10490 91 SEFDLDAALARRPALILMDELAHSNAPGSRHPKRWQDVEELLEAGIDVFTTVNVQHLESLNDVVGGVTGIQVRETVPDPF 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 170 LDRLHDIVLVDLPPRELIARLQQGKVYVPEQAAQALQAFFSPANLTALRELAMQEAADRVDSSLRETRAARGEGNL-PLR 248
Cdd:PRK10490 171 FDAADEVVLVDLPPDDLRQRLNEGKVYIAGQAERAIEHFFRKGNLIALRELALRRTADRVDDQMRAWRDHQGEEKVwHTR 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 249 RGVLVAIDGGGQSEYLVRVARRIAERRDAPWTVVTVQS---RRQDEATRREIDAAFALARRLGGDAELLHGSSIADALLD 325
Cdd:PRK10490 251 DAILLCIGHNTGSEKLVRTAARLAARLGSVWHAVYVETprlHRLPEKKRRAILSALRLAQELGAETATLSDPAEEKAVLR 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 326 HAAHNGVSTLVLGRTRERPLARmfNRTLTQQLIQRGAHYEITIISTPQARARSRreGLLPPGRGISYE---PVQALIATA 402
Cdd:PRK10490 331 YAREHNLGKIIIGRRASRRWWR--RESFADRLARLGPDLDLVIVALDEPPARAI--AKAPDSRPFKEKwrvQIQGCLVAI 406
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 403 LACAVAWLAERWVGM----ADLSMVFIVAVVLVAARTRASVAVMAAILCFLAYNFLFIAPRFTFAIGARQGVITVFLFLA 478
Cdd:PRK10490 407 ALCALITLIAMQWLPafdaANLVMLYLLGVVVVALFYGRWPSVVATVINVASFDLFFVAPRGTLAVSDVQYLLTFAVMLT 486
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 479 AALVAGRLASRLRMQVIALRAANRHARARQQLGRQLASAAGNGEVAQAGRHALEQAMDVPAWLRIGADTA--TGGRSQPG 556
Cdd:PRK10490 487 VGLVIGNLTAGVRYQARVARYREQRTRHLYEMSKALAVGLSPEDIAATSEHFLASTFQARSQLLLPDDNGklQPLTHDQG 566
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 557 DT--DLAAADWALRHGQPSGRFTDTLAGAQWWFLPLLDGeDRAIGVAGLYLPGAQARLLPEQRQLAEAMVDDIAQAALRT 634
Cdd:PRK10490 567 MTpwDDAIARWSFDKGQPAGAGTDTLPGVPYQILPLKSA-QKTYGLLAVEPGNLRQLMIPEQQRLLETFTLLIANALERL 645
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 635 RLVAELEQAHVSNETERLRSALLSSVSHDLRSPLAAMIGSAD----SLASYGGA---MDSADRRALLDTIlvegerldRY 707
Cdd:PRK10490 646 TLTASEEQARLASEREQLRNALLAALSHDLRTPLTVLFGQAEiltlDLASEGSPharQASEIRQQVLNTT--------RL 717
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 708 IQNLLDMTRLGHEGLKINRDWIGVDELIGSAARRLQRYQPKVRLELDIPPTLAPIWVHPALVEQAVFNVMENAAKFSPPD 787
Cdd:PRK10490 718 VNNLLDMARIQSGGFNLRKEWLTLEEVVGSALQMLEPGLSGHPINLSLPEPLTLIHVDGPLFERVLINLLENAVKYAGAQ 797
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 788 AAVQVQARELDGQLRIDVIDAGPGIPDDERARIFDMFysvERGDRGRH--GTGLGLTICQGMIGAHGGSVQAlPGRDGRG 865
Cdd:PRK10490 798 AEIGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKF---ARGNKESAipGVGLGLAICRAIVEVHGGTIWA-ENRPEGG 873
|
890 900
....*....|....*....|.
gi 2245002159 866 TLIRITLPLLKPASHDEPDSD 886
Cdd:PRK10490 874 ACFRVTLPLETPPELEEFHED 894
|
|
| KdpD |
pfam02702 |
Osmosensitive K+ channel His kinase sensor domain; This is a family of KdpD sensor kinase ... |
22-229 |
6.15e-129 |
|
Osmosensitive K+ channel His kinase sensor domain; This is a family of KdpD sensor kinase proteins that regulate the kdpFABC operon responsible for potassium transport. The aligned region corresponds to the N-terminal cytoplasmic part of the protein which functions as the sensor domain responsible for sensing turgor pressure. It recognizes C-di-AMP and K+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 460656 [Multi-domain] Cd Length: 210 Bit Score: 385.61 E-value: 6.15e-129
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 22 GKLTVFLGAAPGVGKTYTMLTRAQEQLRRGVDLVVGLVETHGRADTQALLEGLPQLPLKDVAYHGHALQEMDLDAVLARR 101
Cdd:pfam02702 3 GRLKIFLGAAPGVGKTYAMLQEAHRLKKRGVDVVIGYVETHGRPETEALLEGLEVIPRREIEYRGRTLEEMDLDAILARR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 102 PALVLVDELAHRNAPGSRHERRWQDVMELLDAGIDVWTTVNIQHLESLNDVVMRITGVRVSETVPDGVLDRLHDIVLVDL 181
Cdd:pfam02702 83 PEVVLVDELAHTNAPGSRHPKRWQDVEELLDAGIDVYTTVNIQHLESLNDVVEQITGVRVRETVPDSVLDRADEVELVDL 162
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 2245002159 182 PPRELIARLQQGKVYVPEQAAQALQAFFSPANLTALRELAMQEAADRV 229
Cdd:pfam02702 163 TPEELLERLKEGKVYPPEKAERALKNFFRKGNLTALRELALRRVADRV 210
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
635-877 |
4.02e-73 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 239.81 E-value: 4.02e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 635 RLVAELEQAHvsnETERLRSALLSSVSHDLRSPLAAMIGSADSLASYGGaMDSADRRALLDTILVEGERLDRYIQNLLDM 714
Cdd:COG2205 1 ELEEALEELE---ELERLKSEFLANVSHELRTPLTSILGAAELLLDEED-LSPEERRELLEIIRESAERLLRLIEDLLDL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 715 TRLGHEGLKINRDWIGVDELIGSAARRLQRY--QPKVRLELDIPPTLAPIWVHPALVEQAVFNVMENAAKFSPPDAAVQV 792
Cdd:COG2205 77 SRLESGKLSLELEPVDLAELLEEAVEELRPLaeEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 793 QARELDGQLRIDVIDAGPGIPDDERARIFDMFYSVERgDRGRHGTGLGLTICQGMIGAHGGSVQALPgRDGRGTLIRITL 872
Cdd:COG2205 157 SARREGDGVRISVSDNGPGIPEEELERIFERFYRGDN-SRGEGGTGLGLAIVKRIVEAHGGTIWVES-EPGGGTTFTVTL 234
|
....*
gi 2245002159 873 PLLKP 877
Cdd:COG2205 235 PLAES 239
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
485-877 |
5.98e-59 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 206.71 E-value: 5.98e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 485 RLASRLRMQVIALRAANRHARARQQLGRQLASAAGNGEVAQAGRHALEQAMDVPAWLRIGADTATGGRSQPGDTDLAAAD 564
Cdd:COG5002 3 LLLLLLLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 565 WALRHGQPSGRFTDTLAGAQWWFLPLLDGEDRAIGVAGLYLPGAQARLLPEQRQLAEAMVDDIAQAALRTRLVAELEQAh 644
Cdd:COG5002 83 LLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERL- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 645 vsnetERLRSALLSSVSHDLRSPLAAMIGSADSLASyGGAMDSADRRALLDTILVEGERLDRYIQNLLDMTRLGHEGLKI 724
Cdd:COG5002 162 -----EQMRREFVANVSHELRTPLTSIRGYLELLLD-GAADDPEERREYLEIILEEAERLSRLVNDLLDLSRLESGELKL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 725 NRDWIGVDELIGSAARRLQRY--QPKVRLELDIPPTLAPIWVHPALVEQAVFNVMENAAKFSPPDAAVQVQARELDGQLR 802
Cdd:COG5002 236 EKEPVDLAELLEEVVEELRPLaeEKGIELELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQVR 315
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2245002159 803 IDVIDAGPGIPDDERARIFDMFYSVERGD-RGRHGTGLGLTICQGMIGAHGGSVQALPgRDGRGTLIRITLPLLKP 877
Cdd:COG5002 316 ISVRDTGIGIPEEDLPRIFERFYRVDKSRsRETGGTGLGLAIVKHIVEAHGGRIWVES-EPGKGTTFTITLPLARE 390
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
559-874 |
1.01e-54 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 192.82 E-value: 1.01e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 559 DLAAADWALRHGQPSGRFTDTLAGAQWWFLPLLDGEDRAIGVAGLYLPGAQARLLPEQRQLAEAMVDDIAQAALRTRLVA 638
Cdd:COG0642 22 LLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 639 ELEQAhvsnetERLRSALLSSVSHDLRSPLAAMIGSADSLASyggaMDSADRRALLDTILVEGERLDRYIQNLLDMTRLG 718
Cdd:COG0642 102 LLEEA------NEAKSRFLANVSHELRTPLTAIRGYLELLLE----ELDEEQREYLETILRSADRLLRLINDLLDLSRLE 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 719 HEGLKINRDWIGVDELIGSAARRLQRY--QPKVRLELDIPPTLAPIWVHPALVEQAVFNVMENAAKFSPPDAAVQVQARE 796
Cdd:COG0642 172 AGKLELEPEPVDLAELLEEVVELFRPLaeEKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRR 251
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2245002159 797 LDGQLRIDVIDAGPGIPDDERARIFDMFYSVErGDRGRHGTGLGLTICQGMIGAHGGSVQALPgRDGRGTLIRITLPL 874
Cdd:COG0642 252 EGDRVRISVEDTGPGIPPEDLERIFEPFFRTD-PSRRGGGTGLGLAIVKRIVELHGGTIEVES-EPGKGTTFTVTLPL 327
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
656-878 |
1.01e-37 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 146.65 E-value: 1.01e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 656 LLSSVSHDLRSPLAAMIGSADSLASYGGAMDSADRRAL---LDTILVEGERLDRYIQNLLDMTRLGheglKINRDWIGVD 732
Cdd:COG5000 204 LARRIAHEIKNPLTPIQLSAERLRRKLADKLEEDREDLeraLDTIIRQVDRLKRIVDEFLDFARLP----EPQLEPVDLN 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 733 ELIGSAAR--RLQRYQPKVRLELDIPPTLAPIWVHPALVEQAVFNVMENAAKFSPPDAAVQVQARELDGQLRIDVIDAGP 810
Cdd:COG5000 280 ELLREVLAlyEPALKEKDIRLELDLDPDLPEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDNGP 359
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2245002159 811 GIPDDERARIFDMFYSVErgdrgRHGTGLGLTICQGMIGAHGGSVQALPgRDGRGTLIRITLPLLKPA 878
Cdd:COG5000 360 GIPEEVLERIFEPFFTTK-----PKGTGLGLAIVKKIVEEHGGTIELES-RPGGGTTFTIRLPLAEEA 421
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
512-874 |
8.30e-37 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 142.63 E-value: 8.30e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 512 RQLASAAGNGEVAQAGRHALEQAMDVPAWLRIGADTATGGRSQPGDTDLAAADWALRHGQPSGRFTDTLAGAQWWFLPLL 591
Cdd:COG4191 2 LRLLLLLLLLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 592 DGEDRAIGVAGLYLPGAQARLLPEQRQLAEAMVDDIAQAALRTRLV---AELEQAhvsnetERLRS--ALLSSVSHDLRS 666
Cdd:COG4191 82 LGLLLLLLLEALLLLLLAALDAEENAELEELERDITELERAEEELRelqEQLVQS------EKLAAlgELAAGIAHEINN 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 667 PLAAMIGSADSLASY-GGAMDSADRRALLDTILVEGERLDRYIQNLLDMTRLGHEGLK---INRdwiGVDELIGSAARRL 742
Cdd:COG4191 156 PLAAILGNAELLRRRlEDEPDPEELREALERILEGAERAAEIVRSLRAFSRRDEEEREpvdLNE---LIDEALELLRPRL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 743 QRYqpKVRLELDIPPTLAPIWVHPALVEQAVFNVMENAAkfsppDA-------AVQVQARELDGQLRIDVIDAGPGIPDD 815
Cdd:COG4191 233 KAR--GIEVELDLPPDLPPVLGDPGQLEQVLLNLLINAI-----DAmeegeggRITISTRREGDYVVISVRDNGPGIPPE 305
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 2245002159 816 ERARIFDMFYSVergDRGRHGTGLGLTICQGMIGAHGGSVQALPgRDGRGTLIRITLPL 874
Cdd:COG4191 306 VLERIFEPFFTT---KPVGKGTGLGLSISYGIVEKHGGRIEVES-EPGGGTTFTITLPL 360
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
630-874 |
7.01e-36 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 142.29 E-value: 7.01e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 630 AALRTRLVAELEQahVSNETERLRSAL---------LSSVSHDLRSPLAAMIGSADSLAsygGAMDSADRRALLDTILVE 700
Cdd:PRK11100 226 VPLPKLGSSELRE--LAQALESMRVKLegkayveqyVQTLTHELKSPLAAIRGAAELLQ---EDPPPEDRARFTGNILTQ 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 701 GERLDRYIQNLLDMTRLGHEGLKINRDWIGVDELIG--SAARRLQRYQPKVRLELDIPPtlapIWVH--PALVEQAVFNV 776
Cdd:PRK11100 301 SARLQQLIDRLLELARLEQRQELEVLEPVALAALLEelVEAREAQAAAKGITLRLRPDD----ARVLgdPFLLRQALGNL 376
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 777 MENAAKFSPPDAAVQVQARELDGQLRIDVIDAGPGIPDDERARIFDMFYSVERGDRGRHGTGLGLTICQGMIGAHGGSVQ 856
Cdd:PRK11100 377 LDNAIDFSPEGGTITLSAEVDGEQVALSVEDQGPGIPDYALPRIFERFYSLPRPANGRKSTGLGLAFVREVARLHGGEVT 456
|
250
....*....|....*...
gi 2245002159 857 aLPGRDGRGTLIRITLPL 874
Cdd:PRK11100 457 -LRNRPEGGVLATLTLPR 473
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
356-873 |
7.43e-36 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 143.00 E-value: 7.43e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 356 QLIQRGAHYEITIISTPQARARSRREGLLPPGRGISYEPVQALIATALACAVAWLAERWVGMADLSMVFIVAVVLVAART 435
Cdd:COG4251 1 LLLLALLLLLLLLLLLLLLLLLLLLLVLLLALALLLLLALLVLLLLLIRLLLLLLLSLLALLLLLLLLLLLLLVLAALAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 436 RASVAVMAAILCFLAYNFLFIAPRFTFAIGARQGVITVFLFLAAALVAGRLASRLRMQVIALRAANRHARARQQLGRQLA 515
Cdd:COG4251 81 LLLLLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 516 SAAGNGEVAQAGRHALEQAMDVPAWLRIGADTATGGRSQPGDTDLAAADWALRHGQPSGRFTDTLAGAQWWFLPLLDGED 595
Cdd:COG4251 161 LLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 596 RAIGVAGLYLPGAQARLLPEQRQLAEAMVDdiAQAALRtRLVAELEQ-AHVsneterlrsallssVSHDLRSPLAAMIGS 674
Cdd:COG4251 241 LILLLLLLILVLELLELRLELEELEEELEE--RTAELE-RSNEELEQfAYV--------------ASHDLREPLRKISGF 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 675 ADSLASYGGAMDSADRRALLDTILVEGERLDRYIQNLLDMTRLGHEGLKinRDWIGVDELIGSAARRLQRYQPKVRLELD 754
Cdd:COG4251 304 SQLLEEDYGDKLDEEGREYLERIRDAAERMQALIDDLLAYSRVGRQELE--FEPVDLNELLEEVLEDLEPRIEERGAEIE 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 755 IPPtLAPIWVHPALVEQAVFNVMENAAKFSPPDAA--VQVQARELDGQLRIDVIDAGPGIPDDERARIFDMFYSVERGDR 832
Cdd:COG4251 382 VGP-LPTVRGDPTLLRQVFQNLISNAIKYSRPGEPprIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRLHSRDE 460
|
490 500 510 520
....*....|....*....|....*....|....*....|.
gi 2245002159 833 GRhGTGLGLTICQGMIGAHGGSVQAlPGRDGRGTLIRITLP 873
Cdd:COG4251 461 YE-GTGIGLAIVKKIVERHGGRIWV-ESEPGEGATFYFTLP 499
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
588-881 |
1.19e-34 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 136.13 E-value: 1.19e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 588 LPLLDGEDRAIGVAGLYLPGaqarllPEQRQLAEAMVDDIAQaalRTRLVAELEQAhvsnetERLRSA--LLSSVSHDLR 665
Cdd:COG3852 83 LRRKDGEERPVDVSVSPLRD------AEGEGGVLLVLRDITE---RKRLERELRRA------EKLAAVgeLAAGLAHEIR 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 666 SPLAAMIGSADSLASyggAMDSADRRALLDTILVEGERLDRYIQNLLDMTRLGheglKINRDWIGVDELIGSAARRLQ-R 744
Cdd:COG3852 148 NPLTGIRGAAQLLER---ELPDDELREYTQLIIEEADRLNNLVDRLLSFSRPR----PPEREPVNLHEVLERVLELLRaE 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 745 YQPKVRLELDIPPTLAPIWVHPALVEQAVFNVMENAAKFSPPDAAVQVQAR----------ELDGQLRIDVIDAGPGIPD 814
Cdd:COG3852 221 APKNIRIVRDYDPSLPEVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTRverqvtlgglRPRLYVRIEVIDNGPGIPE 300
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2245002159 815 DERARIFDMFYSvergdrGR-HGTGLGLTICQGMIGAHGGSVQALpGRDGRGTLIRITLPLLKPASHD 881
Cdd:COG3852 301 EILDRIFEPFFT------TKeKGTGLGLAIVQKIVEQHGGTIEVE-SEPGKGTTFRIYLPLEQAEEEP 361
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
766-874 |
2.42e-29 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 112.74 E-value: 2.42e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 766 PALVEQAVFNVMENAAKFSPPDAAVQVQARELDGQLRIDVIDAGPGIPDDERARIFDMFYSVERGDRGRHGTGLGLTICQ 845
Cdd:smart00387 3 PDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKIGGTGLGLSIVK 82
|
90 100
....*....|....*....|....*....
gi 2245002159 846 GMIGAHGGSVQALpGRDGRGTLIRITLPL 874
Cdd:smart00387 83 KLVELHGGEISVE-SEPGGGTTFTITLPL 110
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
769-872 |
6.10e-29 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 111.16 E-value: 6.10e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 769 VEQAVFNVMENAAKFSPPDAAVQVQARELDGQLRIDVIDAGPGIPDDERARIFDMFYSVeRGDRGRHGTGLGLTICQGMI 848
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRG-DKSREGGGTGLGLAIVRRIV 79
|
90 100
....*....|....*....|....
gi 2245002159 849 GAHGGSVQALPgRDGRGTLIRITL 872
Cdd:cd00075 80 EAHGGRITVES-EPGGGTTFTVTL 102
|
|
| USP_KdpD-like |
cd01987 |
USP domain of the osmosensitive K+ channel histidine kinase family; The KdpDE two component ... |
251-370 |
1.42e-25 |
|
USP domain of the osmosensitive K+ channel histidine kinase family; The KdpDE two component system is widespread in bacteria and archaea; it controls potassium homeostasis and virulence by regulating the transcription of multiple genes, including a kdpFABC operon, which encodes a high-affinity P-type ATPase transporter. The KdpD histidine kinase (HK, EC:2.7.13.3) contain an N-terminal sensory cytoplasmic region (NTR) composed of KdpD' and universal stress protein (USP) domains, a canonical transmembrane domain, and a cytoplasmic C-terminal region with a transmitter GAF domain and an EnvZ-like catalytic HK domain. Proteins containing the USP domain are induced by many environmental stressors such as nutrient starvation, drought, extreme temperatures, high salinity, and the presence of uncouplers, antibiotics, and metals. It enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.
Pssm-ID: 467491 [Multi-domain] Cd Length: 124 Bit Score: 102.33 E-value: 1.42e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 251 VLVAIDGGGQSEYLVRVARRIAERRDAPWTVVTVQ---SRRQDEATRREIDAAFALARRLGGDAELLHGSSIADALLDHA 327
Cdd:cd01987 2 ILVCISSSPTSEKLIRRAARLAERLNGELTAVYVEtpeESRLDEESQRRLLTNLKLAEELGAEVVSVEGDDVAEAIVEFA 81
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 2245002159 328 AHNGVSTLVLGRTRERPLARMFNRTLTQQLIQRGAHYEITIIS 370
Cdd:cd01987 82 RERNVTQIVLGQSRRRRWRRLFKGSLVDRLLREAPNIDVHIVP 124
|
|
| DUF4118 |
pfam13493 |
Domain of unknown function (DUF4118); This domain is found in a wide variety of bacterial ... |
397-493 |
3.52e-25 |
|
Domain of unknown function (DUF4118); This domain is found in a wide variety of bacterial signalling proteins. It is likely to be a transmembrane domain involved in ligand sensing.
Pssm-ID: 463897 Cd Length: 107 Bit Score: 100.61 E-value: 3.52e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 397 ALIATALACAVAWLAERWVGMADLSMVFIVAVVLVAARTRASVAVMAAILCFLAYNFLFIAPRFTFAIGARQGVITVFLF 476
Cdd:pfam13493 4 AVLILALATLLALLLRPLLPLANIALLFLLAVLLVALRGGRGPGLLAAVLSVLLFNYFFTPPYFTFTVSDPGYLLTLVVF 83
|
90
....*....|....*..
gi 2245002159 477 LAAALVAGRLASRLRMQ 493
Cdd:pfam13493 84 LLVALLTSTLTARLRRQ 100
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
610-879 |
5.46e-24 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 107.75 E-value: 5.46e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 610 ARLLPEQRQLAEAMV---DDIAQAALRTRLvaeleqahvsNETERLRS--ALLSSVSHDLRSPLAAMIGSADSLASYggA 684
Cdd:PRK11360 352 SLLHNTHGEMIGALVifsDLTERKRLQRRV----------ARQERLAAlgELVAGVAHEIRNPLTAIRGYVQIWRQQ--T 419
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 685 MDSADRRALlDTILVEGERLDRYIQNLLDMTRLGHEglkiNRDWIGVDELIGSAARRLQ--RYQPKVRLELDIPPTLAPI 762
Cdd:PRK11360 420 SDPPSQEYL-SVVLREVDRLNKVIDQLLEFSRPRES----QWQPVSLNALVEEVLQLFQtaGVQARVDFETELDNELPPI 494
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 763 WVHPALVEQAVFNVMENAAKFSPPDAAVQVQA-RELDGQLRIDVIDAGPGIPDDERARIFDMFYSVErgdrgRHGTGLGL 841
Cdd:PRK11360 495 WADPELLKQVLLNILINAVQAISARGKIRIRTwQYSDGQVAVSIEDNGCGIDPELLKKIFDPFFTTK-----AKGTGLGL 569
|
250 260 270
....*....|....*....|....*....|....*...
gi 2245002159 842 TICQGMIGAHGGSVQAlPGRDGRGTLIRITLPLLKPAS 879
Cdd:PRK11360 570 ALSQRIINAHGGDIEV-ESEPGVGTTFTLYLPINPQGN 606
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
650-877 |
1.16e-23 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 105.40 E-value: 1.16e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 650 ERLRSA---LLSSVSHDLRSPLAAMiGSADSLAsyggamdsadRRAL-----LDTILVEGERLDRYIQNLLDMTRLGH-- 719
Cdd:PRK09470 237 ERMMTSqqrLLSDISHELRTPLTRL-QLATALL----------RRRQgeskeLERIETEAQRLDSMINDLLVLSRNQQkn 305
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 720 ----EGLKINRDWigvDELIGSAarRLQRYQPKVRLELDIPPTLAPIWVHPALVEQAVFNVMENAAKFSppDAAVQVQAR 795
Cdd:PRK09470 306 hlerETFKANSLW---SEVLEDA--KFEAEQMGKSLTVSAPPGPWPINGNPNALASALENIVRNALRYS--HTKIEVAFS 378
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 796 ELDGQLRIDVIDAGPGIPDDERARIFDMFYSV-ERGDRGRHGTGLGLTICQGMIGAHGGSVQALPGRDGrGTLIRITLPL 874
Cdd:PRK09470 379 VDKDGLTITVDDDGPGVPEEEREQIFRPFYRVdEARDRESGGTGLGLAIVENAIQQHRGWVKAEDSPLG-GLRLTIWLPL 457
|
...
gi 2245002159 875 LKP 877
Cdd:PRK09470 458 YKR 460
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
647-853 |
2.60e-23 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 103.11 E-value: 2.60e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 647 NET--ERLRSA--LLSSVSHDLRSPLAAMIGSADSLAS----YGGAMDSADRRALLDTILVEGERLDRYIQNLLDMTRLG 718
Cdd:PRK09303 141 NETllEQLKFKdrVLAMLAHDLRTPLTAASLALETLELgqidEDTELKPALIEQLQDQARRQLEEIERLITDLLEVGRTR 220
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 719 HEGLKINRDWIGVDELIGSAARRLQ-RYQPK-VRLELDIPPTLAPIWVHPALVEQAVFNVMENAAKFSPPDAAVQVQARE 796
Cdd:PRK09303 221 WEALRFNPQKLDLGSLCQEVILELEkRWLAKsLEIQTDIPSDLPSVYADQERIRQVLLNLLDNAIKYTPEGGTITLSMLH 300
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 2245002159 797 LDGQ-LRIDVIDAGPGIPDDERARIFDMFYSVERgDRGRHGTGLGLTICQGMIGAHGG 853
Cdd:PRK09303 301 RTTQkVQVSICDTGPGIPEEEQERIFEDRVRLPR-DEGTEGYGIGLSVCRRIVRVHYG 357
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
766-874 |
3.22e-23 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 95.13 E-value: 3.22e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 766 PALVEQAVFNVMENAAKFSPPDAAVQVQARElDGQLRIDVIDAGPGIPDDERARIFDMFYSVERGDRGrhGTGLGLTICQ 845
Cdd:pfam02518 3 ELRLRQVLSNLLDNALKHAAKAGEITVTLSE-GGELTLTVEDNGIGIPPEDLPRIFEPFSTADKRGGG--GTGLGLSIVR 79
|
90 100
....*....|....*....|....*....
gi 2245002159 846 GMIGAHGGSVQaLPGRDGRGTLIRITLPL 874
Cdd:pfam02518 80 KLVELLGGTIT-VESEPGGGTTVTLTLPL 107
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
650-874 |
6.68e-22 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 100.05 E-value: 6.68e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 650 ERLRSA--------LLSSVSHDLRSPLAAMIGSADSLAsyggAMDSADRRALLDTILVEGERLDRYIQNLLDMTRlgHEG 721
Cdd:COG5809 259 ELLRKSeklsvvgeLAAGIAHEIRNPLTSLKGFIQLLK----DTIDEEQKTYLDIMLSELDRIESIISEFLVLAK--PQA 332
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 722 LKINRdwIGVDELIGSAARRL--QRYQPKVRLELDIPPTLAPIWVHPALVEQAVFNVMENAAKFSPPDAAVQVQARELD- 798
Cdd:COG5809 333 IKYEP--KDLNTLIEEVIPLLqpQALLKNVQIELELEDDIPDILGDENQLKQVFINLLKNAIEAMPEGGNITIETKAEDd 410
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2245002159 799 GQLRIDVIDAGPGIPDDERARIFDMFYSV-ERgdrgrhGTGLGLTICQGMIGAHGGSVQAlPGRDGRGTLIRITLPL 874
Cdd:COG5809 411 DKVVISVTDEGCGIPEERLKKLGEPFYTTkEK------GTGLGLMVSYKIIEEHGGKITV-ESEVGKGTTFSITLPI 480
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
613-857 |
2.26e-20 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 95.15 E-value: 2.26e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 613 LPEQRQLAEamVDDIAQAAlrTRLVAELEQAHVsneteRLrSALLSSVSHDLRSPLAAMIGSADSLASYggAMDSADRRA 692
Cdd:TIGR01386 211 LDPSRAPAE--LRELAQSF--NAMLGRLEDAFQ-----RL-SQFSADLAHELRTPLTNLLGQTQVALSQ--PRTGEEYRE 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 693 LLDTILVEGERLDRYIQNLLDMTRLGHEGLKINRDWIgvdELIGSAARRLQRYQP-----KVRLELDIPPTLApiwVHPA 767
Cdd:TIGR01386 279 VLESNLEELERLSRMVSDMLFLARADNGQLALERVRL---DLAAELAKVAEYFEPlaeerGVRIRVEGEGLVR---GDPQ 352
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 768 LVEQAVFNVMENAAKFSPPDAAVQVQARELDGQLRIDVIDAGPGIPDDERARIFDMFYsveRGDRGRH----GTGLGLTI 843
Cdd:TIGR01386 353 MFRRAISNLLSNALRHTPDGGTITVRIERRSDEVRVSVSNPGPGIPPEHLSRLFDRFY---RVDPARSnsgeGTGLGLAI 429
|
250
....*....|....
gi 2245002159 844 CQGMIGAHGGSVQA 857
Cdd:TIGR01386 430 VRSIMEAHGGRASA 443
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
771-874 |
2.69e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 86.78 E-value: 2.69e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 771 QAVFNVMENAAKFSPP-DAAVQVQARELDG---QLRIDVIDAGPGIPDDERARIFDMFYSVERGDRGRH-GTGLGLTICQ 845
Cdd:cd16922 3 QILLNLLGNAIKFTEEgEVTLRVSLEEEEEdgvQLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYgGTGLGLAISK 82
|
90 100
....*....|....*....|....*....
gi 2245002159 846 GMIGAHGGSVQaLPGRDGRGTLIRITLPL 874
Cdd:cd16922 83 KLVELMGGDIS-VESEPGQGSTFTFTLPL 110
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
766-870 |
2.83e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 86.75 E-value: 2.83e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 766 PALVEQAVFNVMENAAKFSPPDAAVQVQARELDGQLRIDVIDAGPGIPDDERARIFDMFYSVERGDRGRHGTGLGLTICQ 845
Cdd:cd16945 2 PFLLRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQKSTGLGLAFVQ 81
|
90 100
....*....|....*....|....*
gi 2245002159 846 GMIGAHGGSVQALPGRDGRGTLIRI 870
Cdd:cd16945 82 EVAQLHGGRITLRNRPDGVLAFLTL 106
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
579-874 |
1.08e-19 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 92.67 E-value: 1.08e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 579 TLAGAqWWFL-----PLLDGEDRAIGVA-GLYLPGaqarlLPEQ-----RQLAEA---MVDDIAQaalrtrlvaeLEQAh 644
Cdd:PRK09467 166 SVAGG-WLFIriqnrPLVALEHAALQVGkGEIPPP-----LREYgasevRSVTRAfnqMAAGIKQ----------LEDD- 228
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 645 vsneterlRSALLSSVSHDLRSPLAAMigsadSLASyggAMDSADRRALLDTILVEGERLDRYIQNLLDMTRLGHEGlki 724
Cdd:PRK09467 229 --------RTLLMAGVSHDLRTPLTRI-----RLAT---EMMSEEDGYLAESINKDIEECNAIIEQFIDYLRTGQEM--- 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 725 NRDWIGVDELIGSAARRLQRYQPKVrlELDIPPTLAPIWVHPALVEQAVFNVMENAAKFSPPDAAVQVQareLDGQL-RI 803
Cdd:PRK09467 290 PMEMADLNALLGEVIAAESGYEREI--ETALQPGPIEVPMNPIAIKRALANLVVNAARYGNGWIKVSSG---TEGKRaWF 364
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2245002159 804 DVIDAGPGIPDDERARIFDMFysvERGD--RGRHGTGLGLTICQGMIGAHGGSVQaLPGRDGRGTLIRITLPL 874
Cdd:PRK09467 365 QVEDDGPGIPPEQLKHLFQPF---TRGDsaRGSSGTGLGLAIVKRIVDQHNGKVE-LGNSEEGGLSARAWLPL 433
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
650-881 |
2.04e-19 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 92.39 E-value: 2.04e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 650 ERLRSALLSSVSHDLRSPLAAMIGSADslasyggAMDSADRRALLDTI---LVEGERLDRYIQNL--LDMTRLGheGLKI 724
Cdd:PRK10549 237 EQMRRDFMADISHELRTPLAVLRGELE-------AIQDGVRKFTPESVaslQAEVGTLTKLVDDLhqLSLSDEG--ALAY 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 725 NRDWIGVDELI--GSAARRlQRYQPK-VRLELDIPPTlAPIWVHPALVEQAVFNVMENAAKFSPPDAAVQVQARELDGQL 801
Cdd:PRK10549 308 RKTPVDLVPLLevAGGAFR-ERFASRgLTLQLSLPDS-ATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTL 385
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 802 RIDVIDAGPGIPDDERARIFDMFYSVErGDRGRH--GTGLGLTICQGMIGAHGGSVQALPGRDGrGTLIRITLPLLKPAS 879
Cdd:PRK10549 386 RLTFADSAPGVSDEQLQKLFERFYRTE-GSRNRAsgGSGLGLAICLNIVEAHNGRIIAAHSPFG-GVSITVELPLERDLQ 463
|
..
gi 2245002159 880 HD 881
Cdd:PRK10549 464 RE 465
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
770-873 |
8.13e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 82.51 E-value: 8.13e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 770 EQAVFNVMENAAKFSPPDAAVQVQARELDGQLRIDVIDAGPGIPDDERARIFDMFYSVERG-DRGRHGTGLGLTICQGMI 848
Cdd:cd16946 6 QQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSrNRASGGSGLGLAICHNIA 85
|
90 100
....*....|....*....|....*
gi 2245002159 849 GAHGGSVQALPGRDGrGTLIRITLP 873
Cdd:cd16946 86 LAHGGTISAEHSPLG-GLRLVLTLP 109
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
770-874 |
5.07e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 80.06 E-value: 5.07e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 770 EQAVFNVMENAAKFSPPDaaVQVQARELDGQLRIDVIDAGPGIPDDERARIFDMFYSV-ERGDRGRHGTGLGLTICQGMI 848
Cdd:cd16949 2 ARALENVLRNALRYSPSK--ILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVdSARDRESGGTGLGLAIAERAI 79
|
90 100
....*....|....*....|....*.
gi 2245002159 849 GAHGGSVQAlPGRDGRGTLIRITLPL 874
Cdd:cd16949 80 EQHGGKIKA-SNRKPGGLRVRIWLPA 104
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
656-874 |
6.67e-18 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 87.53 E-value: 6.67e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 656 LLSSVSHDLRSPLAAMIGsadsLASYGGAMDSA--DRRALLDTILVEGERLDRYIQNLLDMTRLGHEGLKINRdwigVDE 733
Cdd:PRK10364 240 LAAGVAHEIRNPLSSIKG----LAKYFAERAPAggEAHQLAQVMAKEADRLNRVVSELLELVKPTHLALQAVD----LND 311
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 734 LIGSAARRLQR--YQPKVRLELDIPPTLAPIWVHPALVEQAVFNVMENAAKFSPPDAAVQVQARELDGQLRIDVIDAGPG 811
Cdd:PRK10364 312 LINHSLQLVSQdaNSREIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGKG 391
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2245002159 812 IPDDERARIFDMFYSVErgdrgRHGTGLGLTICQGMIGAHGGSVQAlPGRDGRGTLIRITLPL 874
Cdd:PRK10364 392 IAADQLEAIFTPYFTTK-----AEGTGLGLAVVHNIVEQHGGTIQV-ASQEGKGATFTLWLPV 448
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
608-878 |
1.15e-17 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 88.42 E-value: 1.15e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 608 AQARLLPEQRQLAEAMVDdiAQAALRTRLVAELEQAHVSNE-TERLRSALLSSVSHDLRSPLAAMIGSADSLAsygGAMD 686
Cdd:PRK11466 400 SNVHALNRHREQLAAQVK--ARTAELQELVIEHRQARAEAEkASQAKSAFLAAMSHEIRTPLYGILGTAQLLA---DNPA 474
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 687 SADRRALLDTILVEGERLDRYIQNLLDMTRL--GHEGLKINRDWIGVDELIGSAAR----RLQryQPKVRLELDIPPTLa 760
Cdd:PRK11466 475 LNAQRDDLRAITDSGESLLTILNDILDYSAIeaGGKNVSVSDEPFEPRPLLESTLQlmsgRVK--GRPIRLATDIADDL- 551
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 761 PIWVH--PALVEQAVFNVMENAAKFSPpDAAVQVQARELDGQLRIDVIDAGPGIPDDERARIFDMFYSVErGDRGrhGTG 838
Cdd:PRK11466 552 PTALMgdPRRIRQVITNLLSNALRFTD-EGSIVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQVS-GKRG--GTG 627
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 2245002159 839 LGLTICQGMIGAHGGSVQAlPGRDGRGTLIRITLPLLKPA 878
Cdd:PRK11466 628 LGLTISSRLAQAMGGELSA-TSTPEVGSCFCLRLPLRVAT 666
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
769-873 |
1.16e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 78.98 E-value: 1.16e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 769 VEQAVFNVMENAAKFSppdAAVQVQAREL--------DGQLRIDVIDAGPGIPDDERARIFDMFYSVErgdrgRHGTGLG 840
Cdd:cd16920 1 IQQVLINLVRNGIEAM---SEGGCERRELtirtspadDRAVTISVKDTGPGIAEEVAGQLFDPFYTTK-----SEGLGMG 72
|
90 100 110
....*....|....*....|....*....|...
gi 2245002159 841 LTICQGMIGAHGGSVQALPgRDGRGTLIRITLP 873
Cdd:cd16920 73 LSICRSIIEAHGGRLSVES-PAGGGATFQFTLP 104
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
658-886 |
2.48e-17 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 86.92 E-value: 2.48e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 658 SSVSHDLRSPLAAMIGSADSLasyggaMD---SADRRALLDTILVEGERLDRYIQNLLDMTRLGHEGLKINRDWIGVDEL 734
Cdd:PRK11091 288 STISHELRTPLNGIVGLSRIL------LDtelTAEQRKYLKTIHVSAITLGNIFNDIIDMDKMERRKLQLDNQPIDFTDF 361
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 735 IG--SAARRLQRYQPKVRLELDIPPTLaPIWVH--PALVEQAVFNVMENAAKFSPPDAAVQVQARELDGQLRIDVIDAGP 810
Cdd:PRK11091 362 LAdlENLSGLQAEQKGLRFDLEPLLPL-PHKVItdGTRLRQILWNLISNAVKFTQQGGVTVRVRYEEGDMLTFEVEDSGI 440
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 811 GIPDDERARIFDMFYSVERGDRGRH--GTGLGLTICQGMIGAHGG--SVQALPGRDGRGTLiRITLPLLKPASHDEPDSD 886
Cdd:PRK11091 441 GIPEDELDKIFAMYYQVKDSHGGKPatGTGIGLAVSKRLAQAMGGdiTVTSEEGKGSCFTL-TIHAPAVAEEVEDAFDED 519
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
771-873 |
1.54e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 75.89 E-value: 1.54e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 771 QAVF-NVMENAAKFSPPDAAVQVQARELDGQLRIDVIDAGPGIPDDERARIFDMFYsveRGDRGRH--GTGLGLTICQGM 847
Cdd:cd16923 2 QRVFsNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFY---RGDNSRNteGAGLGLSIAKAI 78
|
90 100
....*....|....*....|....*.
gi 2245002159 848 IGAHGGSVQALpgRDGRGTLIRITLP 873
Cdd:cd16923 79 IELHGGSASAE--YDDNHDLFKVRLP 102
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
733-855 |
5.01e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 75.36 E-value: 5.01e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 733 ELIGSAARRLQR-YQPK-VRLELDIPPTLAPIWVHPALVEqAVFNVMENAAKFSppDAAVQVQARELDGQLRIDVIDAGP 810
Cdd:cd16954 1 PLLDSLCSALNKvYQRKgVSISLDISPELRFPGERNDLME-LLGNLLDNACKWC--LEFVEVTARQTDGGLHLIVDDDGP 77
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 2245002159 811 GIPDDERARIFDmfySVERGDRGRHGTGLGLTICQGMIGAHGGSV 855
Cdd:cd16954 78 GVPESQRSKIFQ---RGQRLDEQRPGQGLGLAIAKEIVEQYGGEL 119
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
769-873 |
5.51e-16 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 74.45 E-value: 5.51e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 769 VEQAVFNVMENAAKFSPPDAAVQ--VQARELDGQLrIDVIDAGPGIPDDERARIFDMFYSV-ERGDRGRHGTGLGLTICQ 845
Cdd:cd16925 5 YERVVLNLLSNAFKFTPDGGRIRciLEKFRLNRFL-LTVSDSGPGIPPNLREEIFERFRQGdGSSTRAHGGTGLGLSIVK 83
|
90 100
....*....|....*....|....*...
gi 2245002159 846 GMIGAHGGSVqALPGRDGRGTLIRITLP 873
Cdd:cd16925 84 EFVELHGGTV-TVSDAPGGGALFQVELP 110
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
626-874 |
1.04e-15 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 81.94 E-value: 1.04e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 626 DIAQAAlrtrlvaelEQAHVSneterlRSALLSSVSHDLRSPLAAMIGSADSLASYG---------GAMDSADrrALLDT 696
Cdd:PRK10841 435 EMAQAA---------EQASQS------KSMFLATVSHELRTPLYGIIGNLDLLQTKElpkgvdrlvTAMNNSS--SLLLK 497
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 697 IlvegerldryIQNLLDMTRLGHEGLKINRDWIGVDELIgsaARRLQRYQP---KVRLEL------DIPPTLAPiwvHPA 767
Cdd:PRK10841 498 I----------ISDILDFSKIESEQLKIEPREFSPREVI---NHITANYLPlvvKKRLGLycfiepDVPVALNG---DPM 561
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 768 LVEQAVFNVMENAAKFSPPDAAVqVQARELDGQLRIDVIDAGPGIPDDERARIFDMFYSVERG-DRGRHGTGLGLTICQG 846
Cdd:PRK10841 562 RLQQVISNLLSNAIKFTDTGCIV-LHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGvQRNFQGTGLGLAICEK 640
|
250 260 270
....*....|....*....|....*....|
gi 2245002159 847 MIGAHGG--SVQALPgrdGRGTLIRITLPL 874
Cdd:PRK10841 641 LINMMDGdiSVDSEP---GMGSQFTIRIPL 667
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
702-874 |
3.22e-15 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 78.74 E-value: 3.22e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 702 ERLDRYIQNLLDMTRLGHEGLKINRDWIGVDELIGSAARRLQryQPKVRLELDIPPTLAPIWVHPALVEQAVFNVMENA- 780
Cdd:COG3290 217 DEALEYIDEISEELQELIDSLLSRIGNPVLAALLLGKAARAR--ERGIDLTIDIDSDLPDLPLSDTDLVTILGNLLDNAi 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 781 ---AKFSPPDAAVQVQARELDGQLRIDVIDAGPGIPDDERARIFDMFYSVERGdrgrHGTGLGLTICQGMIGAHGGSVQa 857
Cdd:COG3290 295 eavEKLPEEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGFSTKLG----EGRGLGLALVKQIVEKYGGTIE- 369
|
170
....*....|....*..
gi 2245002159 858 LPGRDGRGTLIRITLPL 874
Cdd:COG3290 370 VESEEGEGTVFTVRLPK 386
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
653-874 |
6.91e-15 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 78.11 E-value: 6.91e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 653 RSALLSSVSHDLRSPLAAMigsadslaSYGGAM----DSADRRALLDTIlvegERLDRYIQNLLDMTRLGHEGLKINRDW 728
Cdd:PRK10604 212 KKQLIDGIAHELRTPLVRL--------RYRLEMsdnlSAAESQALNRDI----GQLEALIEELLTYARLDRPQNELHLSE 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 729 IGVDELIGSAARRLQRYQPKVRLELDIPPTLAPIWVHPALVEQAVFNVMENAAKFSppDAAVQVQARELDGQLRIDVIDA 808
Cdd:PRK10604 280 PDLPAWLSTHLADIQAVTPEKTVRLDTPHQGDYGALDMRLMERVLDNLLNNALRYA--HSRVRVSLLLDGNQACLIVEDD 357
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2245002159 809 GPGIPDDERARIFDMFYSVERG-DRGRHGTGLGLTICQGMIGAHGGSVQALPGRDGrGTLIRITLPL 874
Cdd:PRK10604 358 GPGIPPEERERVFEPFVRLDPSrDRATGGCGLGLAIVHSIALAMGGSVNCDESELG-GARFSFSWPV 423
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
769-873 |
7.36e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 71.28 E-value: 7.36e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 769 VEQAVFNVMENAAKFSPP-DAAVQVQARELDG----------QLRIDVIDAGPGIPDDERARIFDMFYSvergdrGR-HG 836
Cdd:cd16918 1 LIQVFLNLVRNAAQALAGsGGEIILRTRTQRQvtlghprhrlALRVSVIDNGPGIPPDLQDTIFYPMVS------GReNG 74
|
90 100 110
....*....|....*....|....*....|....*....
gi 2245002159 837 TGLGLTICQGMIGAHGG--SVQALPGRdgrgTLIRITLP 873
Cdd:cd16918 75 TGLGLAIAQNIVSQHGGviECDSQPGH----TVFSVSLP 109
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
766-874 |
9.40e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 70.91 E-value: 9.40e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 766 PALVEQAVFNVMENAAKFSPPDAAVQVQARELDGQLRIDVIDAGPGIPDDERARIFDMFYSVER-GDrgrhGTGLGLTIC 844
Cdd:cd16943 1 PSQLNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPvGE----GTGLGLSLS 76
|
90 100 110
....*....|....*....|....*....|..
gi 2245002159 845 QGMIGAHGGS--VQALPgrdGRGTLIRITLPL 874
Cdd:cd16943 77 YRIIQKHGGTirVASVP---GGGTRFTIILPI 105
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
639-874 |
1.57e-14 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 78.24 E-value: 1.57e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 639 ELEQAHVSNETERlRSALLSSVSHDLRSPLAAMIGSADSLAsyGGAMDSADRRALLDTILVEGERLDRYIQNLLDMTRLG 718
Cdd:PRK09959 699 EVERNKAINATVA-KSQFLATMSHEIRTPISSIMGFLELLS--GSGLSKEQRVEAISLAYATGQSLLGLIGEILDVDKIE 775
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 719 HEGLKINRDWIGVDELIGSAARRLQRYQPKVRLELDIPPTLAP---IWVHPALVEQAVFNVMENAAKFSpPDAAVQVQAR 795
Cdd:PRK09959 776 SGNYQLQPQWVDIPTLVQNTCHSFGAIAASKSIALSCSSTFPDhylVKIDPQAFKQVLSNLLSNALKFT-TEGAVKITTS 854
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 796 --ELDGQ---LRIDVIDAGPGIPDDERARIFDMfYSVERGDRGRHGTGLGLTICQGMIGAHGGSVqALPGRDGRGTLIRI 870
Cdd:PRK09959 855 lgHIDDNhavIKMTIMDSGSGLSQEEQQQLFKR-YSQTSAGRQQTGSGLGLMICKELIKNMQGDL-SLESHPGIGTTFTI 932
|
....
gi 2245002159 871 TLPL 874
Cdd:PRK09959 933 TIPV 936
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
769-873 |
2.23e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 69.79 E-value: 2.23e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 769 VEQAVFNVMENAAKFSppDAAVQVQARELDGQLRIDVIDAGPGIPDDERARIFDMFYSVERGdRGRHGTGLGLTICQGMI 848
Cdd:cd16950 1 LKRVLSNLVDNALRYG--GGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNA-RGTSGTGLGLAIVQRIS 77
|
90 100
....*....|....*....|....*
gi 2245002159 849 GAHGGSVQALPgRDGRGTLIRITLP 873
Cdd:cd16950 78 DAHGGSLTLAN-RAGGGLCARIELP 101
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
759-872 |
3.25e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 69.74 E-value: 3.25e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 759 LAPIWVH--PALVEQAVFNVMENAAKFSPPDAAVQVQARELDGQLrIDVIDAGPGIPDDERARIFDMFYsveRGDrGRH- 835
Cdd:cd16940 2 AADIQVQgdALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADDGAV-IRVEDNGPGIDEEELEALFERFY---RSD-GQNy 76
|
90 100 110
....*....|....*....|....*....|....*...
gi 2245002159 836 -GTGLGLTICQGMIGAHGGSVQaLPGRDGRGTLIRITL 872
Cdd:cd16940 77 gGSGLGLSIVKRIVELHGGQIF-LGNAQGGGLEAWVRL 113
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
769-873 |
4.32e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 68.89 E-value: 4.32e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 769 VEQAVFNVMENAAKFSPPD--AAVQVQARELDGQLRIDVIDAGPGIPDDERARIFDMFYSVErGDRGRHGTGLGLTICQG 846
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRrpPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLH-SREEYEGTGVGLAIVRK 79
|
90 100
....*....|....*....|....*..
gi 2245002159 847 MIGAHGGSVQaLPGRDGRGTLIRITLP 873
Cdd:cd16921 80 IIERHGGRIW-LESEPGEGTTFYFTLP 105
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
538-879 |
4.59e-14 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 76.64 E-value: 4.59e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 538 PAWLRIGADTATGGRSQPGDTDLAAADWALRHgqpSGRFTDtlAGAQWWFLPLLDGEDRAIGVAGLYLPGAQARLLPEQR 617
Cdd:PRK13837 337 PVWPDRLRALASTVKAAERDVVFVDRNGPVRK---RSCLTR--RGPALWACLAFKSGDRIVALLGLGRQRYGLRPPAGEL 411
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 618 QLAEAMVDDIAQAALRTRLVAELEQAHVSNE-TERLRS--ALLSSVSHDLRSPLAAMIGSA----DSLAsyggamDSADR 690
Cdd:PRK13837 412 QLLELALDCLAHAIERRRLETERDALERRLEhARRLEAvgTLASGIAHNFNNILGAILGYAemalNKLA------RHSRA 485
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 691 RALLDTILVEGERLDRYIQNLLDMTRLGHEglkiNRDWIGVDELIGSAARRLQ-RYQPKVRLELDIPPTLAPIWVHPALV 769
Cdd:PRK13837 486 ARYIDEIISAGARARLIIDQILAFGRKGER----NTKPFDLSELVTEIAPLLRvSLPPGVELDFDQDQEPAVVEGNPAEL 561
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 770 EQAVFNVMENAAKFSPPDAAVQVQARELDGQ---------------LRIDVIDAGPGIPDDERARIFDMFYSVERGdrgr 834
Cdd:PRK13837 562 QQVLMNLCSNAAQAMDGAGRVDISLSRAKLRapkvlshgvlppgryVLLRVSDTGAGIDEAVLPHIFEPFFTTRAG---- 637
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 2245002159 835 hGTGLGLTICQGMIGAHGG--SVQALPgrdGRGTLIRITLPLLKPAS 879
Cdd:PRK13837 638 -GTGLGLATVHGIVSAHAGyiDVQSTV---GRGTRFDVYLPPSSKVP 680
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
635-874 |
5.45e-14 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 74.35 E-value: 5.45e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 635 RLVAELEQaHVSNETERLrsaLLSSVSHDLRSPLAAMIGSADSLAsyggamdsadrRALLDTILVEG-----ERLDRyIQ 709
Cdd:PRK11073 116 RLSQEQLQ-HAQQVAARD---LVRGLAHEIKNPLGGLRGAAQLLS-----------KALPDPALTEYtkviiEQADR-LR 179
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 710 NLLDmtRL---GHEGLKINrdwigvdELIGSAARRLQRY-----QPKVRLELDIPPTLAPIWVHPALVEQAVFNVMENAA 781
Cdd:PRK11073 180 NLVD--RLlgpQRPGTHVT-------ESIHKVAERVVQLvslelPDNVRLIRDYDPSLPELAHDPDQIEQVLLNIVRNAL 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 782 K-FSPPDAAVQVQAR-----ELDGQ-----LRIDVIDAGPGIPDDerarIFD-MFYSVERGDRGrhGTGLGLTICQGMIG 849
Cdd:PRK11073 251 QaLGPEGGTITLRTRtafqlTLHGEryrlaARIDIEDNGPGIPPH----LQDtLFYPMVSGREG--GTGLGLSIARNLID 324
|
250 260
....*....|....*....|....*..
gi 2245002159 850 AHGG--SVQALPGRdgrgTLIRITLPL 874
Cdd:PRK11073 325 QHSGkiEFTSWPGH----TEFSVYLPI 347
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
628-874 |
2.86e-13 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 73.91 E-value: 2.86e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 628 AQAALRTRLVAELEQ-AHVSNeteRLRSALLSSVSHDLRSPLAAMIGSADSLASygGAMDsADRRALLDTILVEGERLDR 706
Cdd:PRK15347 375 NKVAERTQALAEAKQrAEQAN---KRKSEHLTTISHEIRTPLNGVLGALELLQN--TPLT-AEQMDLADTARQCTLSLLA 448
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 707 YIQNLLDMTRLGHEGLKINRDWIGVDELIGSAARRLQ-RYQPKvRLEL------DIPPTLApiwVHPALVEQAVFNVMEN 779
Cdd:PRK15347 449 IINNLLDFSRIESGQMTLSLEETALLPLLDQAMLTIQgPAQSK-SLTLrtfvgaHVPLYLH---LDSLRLRQILVNLLGN 524
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 780 AAKFSpPDAAVQVQARELDGQLRIDVIDAGPGIPDDERARIFDMFYSVergDRGRHGTGLGLTICQGMIGAHGGS--VQA 857
Cdd:PRK15347 525 AVKFT-ETGGIRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQA---DTHSQGTGLGLTIASSLAKMMGGEltLFS 600
|
250
....*....|....*..
gi 2245002159 858 LPgrdGRGTLIRITLPL 874
Cdd:PRK15347 601 TP---GVGSCFSLVLPL 614
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
769-859 |
1.57e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 64.40 E-value: 1.57e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 769 VEQAVFNVMENA--AKFSPPDAAVQVQARELDGQLRIDVIDAGPGIPDDERARIFDMFYSVErgDRGRhGTGLGLTICQG 846
Cdd:cd16976 1 IQQVLMNLLQNAldAMGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTK--PVGK-GTGLGLSISYG 77
|
90
....*....|...
gi 2245002159 847 MIGAHGGSVQALP 859
Cdd:cd16976 78 IVEEHGGRLSVAN 90
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
769-874 |
1.92e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 64.37 E-value: 1.92e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 769 VEQAVFNVMENAAKFSppDAAVQVQARELDGQLRIDVIDAGPGIPDDERARIFDMFYSVERG-DRGRHGTGLGLTICQGM 847
Cdd:cd16939 1 MARALDNLLRNALRYA--HRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSrDRATGGFGLGLAIVHRV 78
|
90 100
....*....|....*....|....*..
gi 2245002159 848 IGAHGGSVQALPGRDGrGTLIRITLPL 874
Cdd:cd16939 79 ALWHGGHVECDDSELG-GACFRLTWPR 104
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
771-857 |
2.04e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 64.52 E-value: 2.04e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 771 QAVFNVMENAAKFSPPDAA-VQVQARELDGQLRIDVIDAGPGIPDDERARIFDMFYSvERGDRGRHGT--GLGLTICQGM 847
Cdd:cd16953 3 QVLRNLIGNAISFSPPDTGrITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYT-ERPANEAFGQhsGLGLSISRQI 81
|
90
....*....|
gi 2245002159 848 IGAHGGSVQA 857
Cdd:cd16953 82 IEAHGGISVA 91
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
632-873 |
2.86e-12 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 69.23 E-value: 2.86e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 632 LRTRLVAELEQahvsnetERLRSAllsSVSHDLRSPLAAMIGSADSLASYGgamdSADRRALLDTIlvegERLDRYIQNL 711
Cdd:PRK10755 126 LVSRLTSTLDQ-------ERLFTA---DVAHELRTPLAGIRLHLELLEKQH----HIDVAPLIARL----DQMMHTVEQL 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 712 LDMTRLG-------HEGLKINRDWI--GVDELIGSAARRLQRyqpkvrleLDIPPTLAPIWVH--PALVEQAVFNVMENA 780
Cdd:PRK10755 188 LQLARAGqsfssghYQTVKLLEDVIlpSQDELSEMLEQRQQT--------LLLPESAADITVQgdATLLRLLLRNLVENA 259
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 781 AKFSPPDAAVQVQARELDGQLRIDVIDAGPGIPDDERARIFDMFYsveRGDRGRHGTGLGLTICQGMIGAHGGSVQALPG 860
Cdd:PRK10755 260 HRYSPEGSTITIKLSQEDGGAVLAVEDEGPGIDESKCGELSKAFV---RMDSRYGGIGLGLSIVSRITQLHHGQFFLQNR 336
|
250
....*....|...
gi 2245002159 861 RDGRGTLIRITLP 873
Cdd:PRK10755 337 QERSGTRAWVWLP 349
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
771-874 |
3.88e-12 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 69.76 E-value: 3.88e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 771 QAVFNVMENAAKFSPPDAAVQVQARELDGQLRIDVIDAGPGIPDDERARIFDMFYSVErgdrgRHGTGLGLTICQGMIGA 850
Cdd:COG5805 398 QVFINLIKNAIEAMPNGGTITIHTEEEDNSVIIRVIDEGIGIPEERLKKLGEPFFTTK-----EKGTGLGLMVSYKIIEN 472
|
90 100
....*....|....*....|....
gi 2245002159 851 HGGSVQALPGRdGRGTLIRITLPL 874
Cdd:COG5805 473 HNGTIDIDSKV-GKGTTFTITLPL 495
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
650-716 |
4.60e-12 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 61.84 E-value: 4.60e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2245002159 650 ERLRSALLSSVSHDLRSPLAAMIGSADSLASYGGamDSADRRALLDTILVEGERLDRYIQNLLDMTR 716
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELL--DDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
749-873 |
6.33e-12 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 69.03 E-value: 6.33e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 749 VRLELDIPPTLapIWVHPALVEQAVFNVMENAAKFSPPDAAVQVQARELDGQLRIDVIDAGPGIPDDERARIFDMFYSVE 828
Cdd:PRK09835 358 VELRFVGDPCQ--VAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVD 435
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 2245002159 829 RG-DRGRHGTGLGLTICQGMIGAHGGSVQAlpGRDGRGTLIRITLP 873
Cdd:PRK09835 436 PSrQRKGEGSGIGLAIVKSIVVAHKGTVAV--TSDARGTRFVISLP 479
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
653-720 |
3.21e-11 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 59.53 E-value: 3.21e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2245002159 653 RSALLSSVSHDLRSPLAAMIGSADSLASYGgamDSADRRALLDTILVEGERLDRYIQNLLDMTRLGHE 720
Cdd:pfam00512 2 KSEFLANLSHELRTPLTAIRGYLELLRDEK---LDEEQREYLETILRSAERLLRLINDLLDLSRIEAG 66
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
645-857 |
3.26e-11 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 66.58 E-value: 3.26e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 645 VSNETERL---RSALlSSVSHDLRSPLAAMIGSADSLASyGGAMDSADRRA-LLDTIlvegERLDRYIQNLLDMTRLGHE 720
Cdd:PRK10815 256 LKNERERYtkyRTTL-TDLTHSLKTPLAVLQSTLRSLRS-GKQMSVEQAEPiMLEQI----SRISQQIGYYLHRASMRSE 329
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 721 GLKINRDWIGVDELIGSAARRLQR-YQPK-VRLELDIPPTLapIWVHpalvEQAVF-----NVMENAAK----Fsppdaa 789
Cdd:PRK10815 330 HNLLSRELHSVAPLLDNLTSALNKvYQRKgVNITLDISPEI--TFVG----EKNDFmevmgNVLDNACKycleF------ 397
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2245002159 790 VQVQARELDGQLRIDVIDAGPGIPDDERARIFDmfySVERGDRGRHGTGLGLTICQGMIGAHGGSVQA 857
Cdd:PRK10815 398 VEISARQTDEHLHIVVEDDGPGIPESKRELIFD---RGQRADTLRPGQGLGLSVAREITEQYEGKISA 462
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
656-883 |
3.65e-11 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 66.62 E-value: 3.65e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 656 LLSSVSHDLRSPLAAMIGSADSLASY--GGAMDSADRRALLDTILVEGERLDRYIQNLLDMTRLGH-EGLKINRDwiGVD 732
Cdd:PRK13557 166 LTGGIAHDFNNLLQVMSGYLDVIQAAlsHPDADRGRMARSVENIRAAAERAATLTQQLLAFARKQRlEGRVLNLN--GLV 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 733 ELIGSAARRlqRYQPKVRLELDIPPTLAPIWVHPALVEQAVFNVMENAAKFSPPDAAVQVQARELD---------GQLR- 802
Cdd:PRK13557 244 SGMGELAER--TLGDAVTIETDLAPDLWNCRIDPTQAEVALLNVLINARDAMPEGGRVTIRTRNVEiededlamyHGLPp 321
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 803 -----IDVIDAGPGIPDDERARIFDMFYSVErgDRGRhGTGLGLTICQGMIGAHGGSVQaLPGRDGRGTLIRITLPLLKP 877
Cdd:PRK13557 322 gryvsIAVTDTGSGMPPEILARVMDPFFTTK--EEGK-GTGLGLSMVYGFAKQSGGAVR-IYSEVGEGTTVRLYFPASDQ 397
|
....*.
gi 2245002159 878 ASHDEP 883
Cdd:PRK13557 398 AENPEQ 403
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
768-873 |
3.77e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 60.63 E-value: 3.77e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 768 LVEQAVFNVMENAAK------FSPPDAAVQVQArELDGQLRIDVIDAGPGIPDDERARIFDMFYSvergDRGRhGTGLGL 841
Cdd:cd16944 4 QISQVLTNILKNAAEaiegrpSDVGEVRIRVEA-DQDGRIVLIVCDNGKGFPREMRHRATEPYVT----TRPK-GTGLGL 77
|
90 100 110
....*....|....*....|....*....|..
gi 2245002159 842 TICQGMIGAHGGSVQaLPGRDGRGTLIRITLP 873
Cdd:cd16944 78 AIVKKIMEEHGGRIS-LSNREAGGACIRIILP 108
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
653-720 |
8.30e-11 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 58.35 E-value: 8.30e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2245002159 653 RSALLSSVSHDLRSPLAAMIGSADSLASyggAMDSADRRALLDTILVEGERLDRYIQNLLDMTRLGHE 720
Cdd:smart00388 2 KREFLANLSHELRTPLTAIRGYLELLLD---TELSEEQREYLETILREAERLLRLINDLLDLSRIEAG 66
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
694-876 |
1.85e-10 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 64.27 E-value: 1.85e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 694 LDTI----LVEG-ERLDRYIQNLLDMTRLGhegLKINRDWIGV-DELigSAARR---LQ--RYQPKVRLELDIPPTLA-- 760
Cdd:COG2972 260 LNSIrwlaELEDpEEAEEMLEALSKLLRYS---LSKGDELVTLeEEL--ELIKSyleIQklRFGDRLEVEIEIDEELLdl 334
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 761 ---PIWVHPaLVEQAVFNVMENaakfSPPDAAVQVQARELDGQLRIDVIDAGPGIPDDERARIFDMFYSVERGdrgrHGT 837
Cdd:COG2972 335 lipKLILQP-LVENAIEHGIEP----KEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEELSSKGEG----RGI 405
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 2245002159 838 GL---------------GLTICQgmigahggsvqalpgRDGRGTLIRITLPLLK 876
Cdd:COG2972 406 GLrnvrerlklyygeeyGLEIES---------------EPGEGTTVTIRIPLEE 444
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
658-856 |
9.37e-10 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 61.97 E-value: 9.37e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 658 SSVSHDLRSPLAAMIGSADsLASYGGAMDSADRRALLDtiLVEG-ERLDRYIQNLLDMTRLGHEGLKINRDWIGVDELIG 736
Cdd:PRK10337 242 SDAAHELRSPLAALKVQTE-VAQLSDDDPQARKKALLQ--LHAGiDRATRLVDQLLTLSRLDSLDNLQDVAEIPLEDLLQ 318
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 737 SAArrLQRYQP----KVRLELDIPPTLAPIWVHPALVEQAVFNVMENAAKFSPPDAAVQVQAREldgqLRIDVIDAGPGI 812
Cdd:PRK10337 319 SAV--MDIYHTaqqaGIDVRLTLNAHPVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNA----RNFTVRDNGPGV 392
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 2245002159 813 PDDERARIFDMFYSVERGDRGrhGTGLGLTICQGMIGAHGGSVQ 856
Cdd:PRK10337 393 TPEALARIGERFYRPPGQEAT--GSGLGLSIVRRIAKLHGMNVS 434
|
|
| PksD |
COG3321 |
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites ... |
7-622 |
1.08e-09 |
|
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 442550 [Multi-domain] Cd Length: 1386 Bit Score: 62.58 E-value: 1.08e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 7 RQADALVEGLQREAGGKLTVFLGAAPGVgktyTMLTRAQEQLRRGVDLVVGLVETHGRADTQALLEGLPQLPLkdvayHG 86
Cdd:COG3321 774 RQPVRFADAVEALLADGVRVFLEVGPGP----VLTGLVRQCLAAAGDAVVLPSLRRGEDELAQLLTALAQLWV-----AG 844
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 87 HALQEMDLDAVLARRPAlvlvdELAH----RNAPGSRHERRWQDVMELLDAGIDVWTTVNIQHLESLNDVVMRITGVRVS 162
Cdd:COG3321 845 VPVDWSALYPGRGRRRV-----PLPTypfqREDAAAALLAAALAAALAAAAALGALLLAALAAALAAALLALAAAAAAAL 919
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 163 ETVPDGVLDRLHDIVLVDLPPRELIARLQQGKVYVPEQAAQALQAFFSPANLTALRELAMQEAADRVDSSLRETRAARGE 242
Cdd:COG3321 920 ALAAAALAALLALVALAAAAAALLALAAAAAAAAAALAAAEAGALLLLAAAAAAAAAAAAAAAAAAAAAAAAAAAALAAA 999
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 243 GNLPLRRGVLVAIDGGGQSEYLVRVARRIAERRDAPWTVVTVQSRRQDEATRREIDAAFALARRLGGDAELLHGSSIADA 322
Cdd:COG3321 1000 AALALLAAAALLLAAAAAAAALLALAALLAAAAAALAAAAAAAAAAAALAALAAAAAAAAALALALAALLLLAALAELAL 1079
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 323 LLDHAAHNGVSTLVLGRTRERPLARMFNRTLTQQLIQRGAHYEITIISTPQARARSRREGLLPPGRGISYEPVQALIATA 402
Cdd:COG3321 1080 AAAALALAAALAAAALALALAALAAALLLLALLAALALAAAAAALLALAALLAAAAAAAALAAAAAAAAALALAAAAAAL 1159
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 403 LACAVAWLAERWVGMADLSMVFIVAVVLVAARTRASVAVMAAILCFLAYNFLFIAPRFTFAIGARQGVITVFLFLAAALV 482
Cdd:COG3321 1160 AAALAAALLAAAALLLALALALAAALAAALAGLAALLLAALLAALLAALLALALAALAAAAAALLAAAAAAAALALLALA 1239
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 483 AGRLASRLRMQVIALRAANRHARARQQLGRQLASAAGNGEVAQAGRHALEQAMDVPAWLRIGADTATGGRSQPGDTDLAA 562
Cdd:COG3321 1240 AAAAAVAALAAAAAALLAALAALALLAAAAGLAALAAAAAAAAAALALAAAAAAAAAALAALLAAAAAAAAAAAAAAAAA 1319
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 563 ADWALRHGQPSGRFTDTLAGAQWWFLPLLDGEDRAIGVAGLYLPGAQARLLPEQRQLAEA 622
Cdd:COG3321 1320 ALAAALLAAALAALAAAVAAALALAAAAAAAAAAAAAAAAAAALAAAAGAAAAAAALALA 1379
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
772-866 |
1.20e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 56.44 E-value: 1.20e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 772 AVFNVMENAAKFSPPDAAVQVQARELDGQLRIDVIDAGPGIPDDERARIFDMFYSVER-GDRGRHGTGLGLTICQGMIGA 850
Cdd:cd16952 4 AFSNLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIeRCRNTGGTGLGLAIVKHVMSR 83
|
90
....*....|....*...
gi 2245002159 851 HGG--SVQALPGRDGRGT 866
Cdd:cd16952 84 HDArlLIASELGKGSRFT 101
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
752-872 |
1.59e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 56.75 E-value: 1.59e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 752 ELDIPPTlaPIW--VHPALVEQAVFNVMENAAKFSPPDAAVQVQARELDGQLRIDVIDAGPGIPDDERARIFDMFYSVER 829
Cdd:cd16947 4 EINIPDR--PIYanANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLED 81
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 2245002159 830 G-DRGRHGTGLGLTICQGMIGAHGGSVqALPGRDGRGTLIRITL 872
Cdd:cd16947 82 SrNSAKQGNGLGLTITKRLAESMGGSI-YVNSKPYEKTVFTVTL 124
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
621-874 |
3.62e-09 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 60.63 E-value: 3.62e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 621 EAMVDDIAQAA--LRtrlvaE-LEQAHVSN-----------ETERLRSALLSSVSHDLRSPLAAMIGSAdslasyggamd 686
Cdd:PRK11107 252 EEMQQNIDQATsdLR-----EtLEQMEIQNveldlakkraqEAARIKSEFLANMSHELRTPLNGVIGFT----------- 315
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 687 sadrRALLDTILVEGERlDrYIQ-------NL-------LDMTRLghEGLKIN--------RDWIgvDE---LIGSAARR 741
Cdd:PRK11107 316 ----RQTLKTPLTPTQR-D-YLQtiersanNLlaiindiLDFSKL--EAGKLVlenipfslRETL--DEvvtLLAHSAHE 385
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 742 LQryqpkvrLEL--DIPPTLAPIWVHPAL-VEQAVFNVMENAAKFSPP-DAAVQVQARELDG---QLRIDVIDAGPGIPD 814
Cdd:PRK11107 386 KG-------LELtlNIDPDVPDNVIGDPLrLQQIITNLVGNAIKFTESgNIDILVELRALSNtkvQLEVQIRDTGIGISE 458
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2245002159 815 DERARIFDMF----YSVERgdrgRH-GTGLGLTICQGMIGAHGGSVQaLPGRDGRGTLIRITLPL 874
Cdd:PRK11107 459 RQQSQLFQAFrqadASISR----RHgGTGLGLVITQKLVNEMGGDIS-FHSQPNRGSTFWFHLPL 518
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
615-854 |
4.67e-09 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 60.09 E-value: 4.67e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 615 EQRQLAEAMVDD--IAQAALRT---RLVAELEQAHVSneterlrsALLSSVSHDLRSPLAAMIGSADSLASYGGAMDSAD 689
Cdd:COG4192 398 EKTQELETEIEErkRIEKNLRQtqdELIQAAKMAVVG--------QTMTSLAHELNQPLNAMSMYLFSAKKALEQENYAQ 469
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 690 RRALLDTILVEGERLDRYIQNLLDMTRLGHEGLK-------INRDWigvdELIGSAARRLQryqpkvrLELDIPPTLaPI 762
Cdd:COG4192 470 LPTSLDKIEGLIERMDKIIKSLRQFSRKSDTPLQpvdlrqvIEQAW----ELVESRAKPQQ-------ITLHIPDDL-MV 537
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 763 WVHPALVEQAVFNVMENAAKFSPPDAAVQVQARELDGQLRIDVIDAGPGIPDDEraRIFDMFYSVErgdrgRHGTGLGLT 842
Cdd:COG4192 538 QGDQVLLEQVLVNLLVNALDAVATQPQISVDLLSNAENLRVAISDNGNGWPLVD--KLFTPFTTTK-----EVGLGLGLS 610
|
250
....*....|..
gi 2245002159 843 ICQGMIGAHGGS 854
Cdd:COG4192 611 ICRSIMQQFGGD 622
|
|
| UspA |
COG0589 |
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms]; |
251-360 |
6.72e-09 |
|
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
Pssm-ID: 440354 Cd Length: 136 Bit Score: 54.93 E-value: 6.72e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 251 VLVAIDGGGQSEYLVRVARRIAERRDAPWTVVTVQSRRQD-------------EATRREIDAAFALARRLGGDAE--LLH 315
Cdd:COG0589 5 ILVPTDGSEEAERALEYAAELAKALGAELHLLHVVDPPPSaaagpeeleeelrEEAEEALEEAAERLEEAGVEVEtvVRE 84
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 2245002159 316 GsSIADALLDHAAHNGVSTLVLGRTRERPLARMFNRTLTQQLIQR 360
Cdd:COG0589 85 G-DPAEAILEAAEELDADLIVMGSRGRSGLRRLLLGSVAERVLRH 128
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
770-873 |
5.18e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 52.00 E-value: 5.18e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 770 EQAVFNVMENA-------------AKFSPPDAAVQVQAREL-DGQ-LRIDVIDAGPGIPDDERARIFDMFYSVErgDRGR 834
Cdd:cd16919 2 ELAILNLAVNArdampeggrltieTSNQRVDADYALNYRDLiPGNyVCLEVSDTGSGMPAEVLRRAFEPFFTTK--EVGK 79
|
90 100 110
....*....|....*....|....*....|....*....
gi 2245002159 835 hGTGLGLTICQGMIGAHGGSVQaLPGRDGRGTLIRITLP 873
Cdd:cd16919 80 -GTGLGLSMVYGFVKQSGGHLR-IYSEPGVGTTVRIYLP 116
|
|
| Usp |
pfam00582 |
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ... |
251-349 |
6.14e-08 |
|
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.
Pssm-ID: 425765 [Multi-domain] Cd Length: 137 Bit Score: 52.41 E-value: 6.14e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 251 VLVAIDGGGQSEYLVRVARRIAERRDAPWTVVTV-----------------QSRRQDEATRREIDAAFALARRLGGDAEL 313
Cdd:pfam00582 1 ILVAVDGSEESKRALEWAAELAKARGAELILLHVidpppsgaasladesaeEEELELELAEAEALAAAAAAEAGGVKVEV 80
|
90 100 110
....*....|....*....|....*....|....*..
gi 2245002159 314 -LHGSSIADALLDHAAHNGVSTLVLGRTRERPLARMF 349
Cdd:pfam00582 81 vVVVGDPAEEILEVAEEEDADLIVMGSRGRSGLSRLL 117
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
769-873 |
1.35e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 50.75 E-value: 1.35e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 769 VEQAVFNvmenAAKFSPPDAAVQVQARELDGQLRIDVIDAGPGIPDDERARIFDMFYSVERGDRGRHGTGLGLTICQGMI 848
Cdd:cd16948 10 IGQIVSN----ALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQESTGMGLYLVKKLC 85
|
90 100
....*....|....*....|....*..
gi 2245002159 849 G--AHGGSVQALPgrdGRGTLIRITLP 873
Cdd:cd16948 86 DklGHKIDVESEV---GEGTTFTITFP 109
|
|
| USP-like |
cd00293 |
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ... |
251-360 |
2.17e-07 |
|
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.
Pssm-ID: 467483 [Multi-domain] Cd Length: 135 Bit Score: 50.81 E-value: 2.17e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 251 VLVAIDGGGQSEYLVRVARRIAERRDAPWTVVTVQSRRQDEATRREID-----------------AAFALARRLGGDAEL 313
Cdd:cd00293 2 ILVAVDGSEESERALEWALELAKRPGAELTLLHVVDPPPSSSLSGGLEeladelkeeaeelleeaKKLAEEAGVEVETIV 81
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 2245002159 314 LHGsSIADALLDHAAHNGVSTLVLGRTRERPLARMFNRTLTQQLIQR 360
Cdd:cd00293 82 VEG-DPAEAILEEAKELGADLIVMGSRGRSGLKRLLLGSVSEYVLRH 127
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
604-884 |
1.06e-06 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 52.63 E-value: 1.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 604 YLPGAQARLLPEQRQlaEAMVDDIAQAALRtrlvaELEQAHVSneterlRSALLSSVSHDLRSPLAAMIGSADSLasyGG 683
Cdd:PRK10618 414 LAPRTQLFLLRDQDR--EVLVNKKLQQAQR-----EYEKNQQA------RKAFLQNIGDELKQPLQSLAQLAAQL---RQ 477
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 684 AMDSADRRALLDTILVEGERLDRYIQNLLDMTRLghEglkiNRDWIGV----------DELIGSAARRLQR--------Y 745
Cdd:PRK10618 478 TSDEEQQQPELDQLAEQSDVLVRLVDNIQLLNML--E----TQDWKPEqelfslqdliDEVLPEVLPAIKRkglqllihN 551
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 746 QPKVRLEL--DIPpTLAPIWVhpALVEQAVFNVmeNAAKFSppdaaVQV-QARELDGQLRIDVIDAGPGIPDDERARIFD 822
Cdd:PRK10618 552 HLKAEQLRigDRD-ALRKILL--LLLNYAITTT--AYGKIT-----LEVdQDESSPDRLTIRILDTGAGVSIKELDNLHF 621
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2245002159 823 MFYSVERGDRGRHGTGLGLTICQGMIGAHGGSVQaLPGRDGRGTLIRITLPLLKPASHDEPD 884
Cdd:PRK10618 622 PFLNQTQGDRYGKASGLTFFLCNQLCRKLGGHLT-IKSREGLGTRYSIHLKMLAADPEVEEE 682
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
775-873 |
2.46e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 46.90 E-value: 2.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 775 NVMENAAKFSPPDAAVQVQARELDGQLRIDVIDAGPGIPDDERARIFDMFYSVeRGDRGRhgtGLGLTICQGMIGAHGGS 854
Cdd:cd16915 11 NALDALAATGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVST-KGQGER---GIGLALVRQSVERLGGS 86
|
90
....*....|....*....
gi 2245002159 855 VqALPGRDGRGTLIRITLP 873
Cdd:cd16915 87 I-TVESEPGGGTTFSIRIP 104
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
775-873 |
8.81e-06 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 49.53 E-value: 8.81e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 775 NVMENA--AKFSPPDAAVQVQARELDGQLRIDVIDAGPGIPDDERARIFDMFYSVERGDRgrhgtGLGLTICQGMIGAHG 852
Cdd:PRK11086 440 NLIENAleAVGGEEGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGYSTKGSNR-----GVGLYLVKQSVENLG 514
|
90 100
....*....|....*....|...
gi 2245002159 853 GS--VQALPgrdGRGTLIRITLP 873
Cdd:PRK11086 515 GSiaVESEP---GVGTQFFVQIP 534
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
650-873 |
1.91e-05 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 48.08 E-value: 1.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 650 ERLRSALLSSVSHDLRSPLAAMIG----SADSlasyggAMDSADRRALLDTILVEGERLDRYIQNLLDMTRLghEGLKIn 725
Cdd:PRK11006 201 EGARRNFFANVSHELRTPLTVLQGylemMQDQ------PLEGALREKALHTMREQTQRMEGLVKQLLTLSKI--EAAPT- 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 726 rdwIGVDELIGSAA--RRLQR-----YQPKVRLELDIPPTLAPIWVHPALvEQAVFNVMENAAKFSPPDAAVQVQARELD 798
Cdd:PRK11006 272 ---IDLNEKVDVPMmlRVLEReaqtlSQGKHTITFEVDNSLKVFGNEDQL-RSAISNLVYNAVNHTPEGTHITVRWQRVP 347
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2245002159 799 GQLRIDVIDAGPGIPDDERARIFDMFYSVERGdRGRH--GTGLGLTICQGMIgAHGGSVQALPGRDGRGTLIRITLP 873
Cdd:PRK11006 348 QGAEFSVEDNGPGIAPEHIPRLTERFYRVDKA-RSRQtgGSGLGLAIVKHAL-SHHDSRLEIESEVGKGTRFSFVLP 422
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
768-855 |
3.99e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 43.60 E-value: 3.99e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 768 LVEQAVFNVMENAAKFSPPDAAVQVQARELDGQLRIDVIDAGPGIPDDERARIFDMFYsveRGDRGRHG---TGLGLTIC 844
Cdd:cd16975 4 LLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFY---RDDTSRRSgghYGMGLYIA 80
|
90
....*....|.
gi 2245002159 845 QGMIGAHGGSV 855
Cdd:cd16975 81 KNLVEKHGGSL 91
|
|
| EntF |
COG1020 |
EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites ... |
28-450 |
2.09e-04 |
|
EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 440643 [Multi-domain] Cd Length: 1329 Bit Score: 45.23 E-value: 2.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 28 LGAAPGVGKTYTMLTRAQEQLRRGVDLVVGLVETHGRADTQALLEGLPQLPLKDVAYHGHALQEMDLDAVLARRPALVLV 107
Cdd:COG1020 892 LLQHPGVREAVVVAREDAPGDKRLVAYVVPEAGAAAAAALLRLALALLLPPYMVPAAVVLLLPLPLTGNGKLDRLALPAP 971
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 108 DELAHRNAPGSRHERR-----WQDVMELLDAGIDVWTTVNIQHLESLNDVVMRITGVRVSETVPDGVLDRLHDIVLVDLP 182
Cdd:COG1020 972 AAAAAAAAAAPPAEEEeeeaaLALLLLLVVVVGDDDFFFFGGGLGLLLLLALARAARLLLLLLLLLLLFLAAAAAAAAAA 1051
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 183 PRELIARLQQGKVYVPEQAAQALQAFFSPANLTALRELAMQEAADRVDSSLRETRAARGEGNLP-----LRRGVLVAIDG 257
Cdd:COG1020 1052 AAAAAAAAAAPLAAAAAPLPLPPLLLSLLALLLALLLLLALLALLALLLLLLLLLLLLALLLLLalllaLLAALRARRAV 1131
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 258 GGQSEYLVRVARRIAERRDAPWTVVTVQSRRQDEATRREIDAAFALARRLGGDAELLHGSSIADALLDHAAHNGVSTLVL 337
Cdd:COG1020 1132 RQEGPRLRLLVALAAALALAALLALLLAAAAAAAELLAAAALLLLLALLLLALLLLLLLLLLLLLLLLLLLLLLLLLLLL 1211
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 338 GRTRERPLARMFNRTLTQQLIQRGAHYEITIISTPQARARSRREGLLPPGRGISYEPVQALIATALACAVAWLAERWVGM 417
Cdd:COG1020 1212 LLLLLLLLLLLLLAAAAAALLALALLLALLALAALLALAALAALAAALLALALALLALALLLLALALLLPALARARAART 1291
|
410 420 430
....*....|....*....|....*....|...
gi 2245002159 418 ADLSMVFIVAVVLVAARTRASVAVMAAILCFLA 450
Cdd:COG1020 1292 ARALALLLLLALLLLLALALALLLLLLLLLALL 1324
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
629-877 |
2.47e-04 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 43.84 E-value: 2.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 629 QAALRTRLVAELEQAHvsnETERLRSA--LLSSVSHDLrsplAAMIGSADsLASYGGAMDSADRRALLDTILVEGERLDR 706
Cdd:COG4585 35 AAELERELAARAEEAR---EEERRRIAreLHDGVGQSL----SAIKLQLE-AARRLLDADPEAAREELEEIRELAREALA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 707 YIQNLLdmTRLGHEGLkinrDWIGVDELIGSAARRLQRyQPKVRLELDIPPTLAPIwvhPALVEQAVFNV----MENAAK 782
Cdd:COG4585 107 ELRRLV--RGLRPPAL----DDLGLAAALEELAERLLR-AAGIRVELDVDGDPDRL---PPEVELALYRIvqeaLTNALK 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 783 FSPPdAAVQVQARELDGQLRIDVIDAGPGIPDDERArifdmfysvergdrgrhGTGLGLTicqGM---IGAHGGSVQALP 859
Cdd:COG4585 177 HAGA-TRVTVTLEVDDGELTLTVRDDGVGFDPEAAP-----------------GGGLGLR---GMrerAEALGGTLTIGS 235
|
250
....*....|....*...
gi 2245002159 860 gRDGRGTLIRITLPLLKP 877
Cdd:COG4585 236 -APGGGTRVRATLPLAAA 252
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
767-877 |
2.19e-03 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 41.74 E-value: 2.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 767 ALVEQAVFNVMENAAKFSPPDAAVQVQARELDGQLRIDVIDAGPGIPDDERARIFDMFYSVERGDRGRHGTGLGLTicQG 846
Cdd:PRK15053 435 AIVGNLLDNAFEASLRSDEGNKIVELFLSDEGDDVVIEVADQGCGVPESLRDKIFEQGVSTRADEPGEHGIGLYLI--AS 512
|
90 100 110
....*....|....*....|....*....|.
gi 2245002159 847 MIGAHGGSVqALPGRDGRGTLIRITLPLLKP 877
Cdd:PRK15053 513 YVTRCGGVI-TLEDNDPCGTLFSIFIPKVKP 542
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
395-874 |
2.33e-03 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 41.43 E-value: 2.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 395 VQALIATALACAVAWLAERWVGMADLSMVFIVAVVLVAARTRASVAVMAAILCFLAYNFLFIAPRFTFAIGARQGVITVF 474
Cdd:COG3920 36 LLLLALLLLALLLASALLALLALSAAALAAALAVALAAAVGAAAALLALLVLLLLLLLAAAALALALLLAALAGLLLLAA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 475 LFLAAALVAGRLASRLRMQVIALRAANRHARARQQLGRQLASAAGNGEVAQAGRHALEQAMDVPAWLRIGADTATGGRSQ 554
Cdd:COG3920 116 LLLLRLVALLAALALLALLLLLLLLLAILALAELAVALAELAAALLLLAEELAALRLAAAALLLLLAALLDLGLALAALA 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 555 PGDTDLAAADWALRHGQPSGRFTDTLAGAQWWFLPLLDGEDRAIGVAGLYLPGAQARLLPEQRQLAEAMVDDIAQAALRT 634
Cdd:COG3920 196 AAALLALLLALELLLALLLLLLLLLALLLVLLAALLRLRAAVLEELERRRRARGLGRLLLLLLLLLLLLRALLLLAAGIR 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 635 RLVAELEQAHVS-NETERLRSALLSSVSHDLRSPLA---AMIG----SADSLASYGGAMDSADR--------RALLDTIL 698
Cdd:COG3920 276 LVITERKRAEEElEASLEEKELLLRELHHRVKNNLQvvsSLLRlqarRADDPEAREALEESQNRiqalalvhELLYQSED 355
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 699 VEGERLDRYIQNLLDMtrlgheglkinrdwigvdeLIGSAARRlqryqpKVRLELDIPPTLAPIwvhpalvEQAV----- 773
Cdd:COG3920 356 WEGVDLRDYLRELLEP-------------------LRDSYGGR------GIRIELDGPDVELPA-------DAAVplgli 403
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 774 FN-VMENAAKFSPPDAA---VQVQARELDGQLRIDVIDAGPGIPDDERArifdmfysvergdrgRHGTGLGLTICQGMIG 849
Cdd:COG3920 404 LNeLVTNALKHAFLSGEggrIRVSWRREDGRLRLTVSDNGVGLPEDVDP---------------PARKGLGLRLIRALVR 468
|
490 500
....*....|....*....|....*
gi 2245002159 850 AHGGSVQAlpgRDGRGTLIRITLPL 874
Cdd:COG3920 469 QLGGTLEL---DRPEGTRVRITFPL 490
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
779-873 |
3.36e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 37.53 E-value: 3.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245002159 779 NAAKFSPPDAAVqVQARELDGQLRIDVIDAGPGIPDDERARifdmfysvergdrgrhGTGLGLTICQGMIGAHGGSVQAL 858
Cdd:cd16917 11 NALKHAGASRVR-VTLSYTADELTLTVVDDGVGFDGPAPPG----------------GGGFGLLGMRERAELLGGTLTIG 73
|
90
....*....|....*
gi 2245002159 859 PgRDGRGTLIRITLP 873
Cdd:cd16917 74 S-RPGGGTRVTARLP 87
|
|
| |
