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Conserved domains on  [gi|2250056290|ref|WP_250697249|]
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phage tail sheath family protein, partial [Escherichia coli]

Protein Classification

phage tail sheath family protein( domain architecture ID 10007475)

phage tail sheath family protein may be encoded in a region together with other putative prophage genes; it may be part of a type 6 secretion system (T6SS) that functions as a contractile injection system utilizing a phage tail-like structure, and is an intracellular system attached to the cytoplasmic membrane, or part of an extracellular contractile injection system (eCIS), such as found in insecticidal antifeeding prophages (Afps)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Phage_sheath_1 super family cl01389
Phage tail sheath protein subtilisin-like domain; This entry represents the second domain in a ...
 2-342 3.14e-130

Phage tail sheath protein subtilisin-like domain; This entry represents the second domain in a variety of phage tail sheath proteins. According to ECOD this domain has a subtilisin-like structure.


The actual alignment was detected with superfamily member PHA02560:

Pssm-ID: 470182 [Multi-domain]  Cd Length: 388  Bit Score: 377.51  E-value: 3.14e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250056290   2 FPLNKPTLLTRVNDVLGKCGTTGTLYRALKAIADQVSTKVIVVRVAEHKEEDGKTQDqlVIGGSEDDGSYTGMYALLVAE 81
Cdd:PHA02560   43 FPLNTPVLITNVVDALGKAGAKGTLPRALDAIADQTKPPTVVVRVAEGADEAATTSN--IIGGVDADGKYTGIKALLAAQ 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250056290  82 qdESIGYRPRILAAPELDTEAVTKSLCVIAGKLRAFVYASCHGCNTMAEAITYRQKFNEREVMLLWPDFIAYNPKSGKNE 161
Cdd:PHA02560  121 --NVLGVKPRILGAPGLDTQAVAVALAAMAQKLRAFAYISAPGCKTKEEAAAYRENFGQREVMVIWPDFKVYDTATNATA 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250056290 162 TFPAPAYACGLRAYIDHEQGWHKSLSNVPVKNVLGMSRHVFWSLQAEDSDANSLNNKEITTIIRRNGFRFWGNRT-PETN 240
Cdd:PHA02560  199 TAPASARAAGLRAKIDNDVGWHKSLSNVGVLGVTGISRDVDWDLQDPSTDANLLNENGVTTLVRRNGFRFWGNRTcSDDP 278

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250056290 241 AYIFEVYTRTAQVLADSIAEAQFETIDSPLTPANVKDVISAIRAKLDSLVTAGKLIGAECWYDVVDNGTTNLRQGRVRIR 320
Cdd:PHA02560  279 LFAFENYVRTAQVIADTIAEAHMWAVDKPLTPSLVRDIVEGINAKFRDLVANGYILGGEAWFDPELNTKETLKAGKLYID 358

                         330       340
                  ....*....|....*....|..
gi 2250056290 321 YKYTPVPPLEDMELYQTFTDEF 342
Cdd:PHA02560  359 YDYTPVPPLEHLTFRQRITDRY 380
 
Name Accession Description Interval E-value
FI PHA02560
major tail sheath protein; Provisional
 2-342 3.14e-130

major tail sheath protein; Provisional


Pssm-ID: 164955 [Multi-domain]  Cd Length: 388  Bit Score: 377.51  E-value: 3.14e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250056290   2 FPLNKPTLLTRVNDVLGKCGTTGTLYRALKAIADQVSTKVIVVRVAEHKEEDGKTQDqlVIGGSEDDGSYTGMYALLVAE 81
Cdd:PHA02560   43 FPLNTPVLITNVVDALGKAGAKGTLPRALDAIADQTKPPTVVVRVAEGADEAATTSN--IIGGVDADGKYTGIKALLAAQ 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250056290  82 qdESIGYRPRILAAPELDTEAVTKSLCVIAGKLRAFVYASCHGCNTMAEAITYRQKFNEREVMLLWPDFIAYNPKSGKNE 161
Cdd:PHA02560  121 --NVLGVKPRILGAPGLDTQAVAVALAAMAQKLRAFAYISAPGCKTKEEAAAYRENFGQREVMVIWPDFKVYDTATNATA 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250056290 162 TFPAPAYACGLRAYIDHEQGWHKSLSNVPVKNVLGMSRHVFWSLQAEDSDANSLNNKEITTIIRRNGFRFWGNRT-PETN 240
Cdd:PHA02560  199 TAPASARAAGLRAKIDNDVGWHKSLSNVGVLGVTGISRDVDWDLQDPSTDANLLNENGVTTLVRRNGFRFWGNRTcSDDP 278

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250056290 241 AYIFEVYTRTAQVLADSIAEAQFETIDSPLTPANVKDVISAIRAKLDSLVTAGKLIGAECWYDVVDNGTTNLRQGRVRIR 320
Cdd:PHA02560  279 LFAFENYVRTAQVIADTIAEAHMWAVDKPLTPSLVRDIVEGINAKFRDLVANGYILGGEAWFDPELNTKETLKAGKLYID 358

                         330       340
                  ....*....|....*....|..
gi 2250056290 321 YKYTPVPPLEDMELYQTFTDEF 342
Cdd:PHA02560  359 YDYTPVPPLEHLTFRQRITDRY 380
COG3497 COG3497
Phage tail sheath protein FI [Mobilome: prophages, transposons];
73-342 1.16e-100

Phage tail sheath protein FI [Mobilome: prophages, transposons];


Pssm-ID: 442720 [Multi-domain]  Cd Length: 273  Bit Score: 298.34  E-value: 1.16e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250056290  73 GMYALLVAeqDESIGYRPRILAAPELDT-EAVTKSLCVIAGKLRAFVYASCHG-CNTMAEAITYRQKFNE--REVMLLWP 148
Cdd:COG3497     1 GLEALEAA--DEKLGVKPRILIAPGLSSlPAVAAALLAHCEKLRAFAILDAPGdGTTLADAIAYRGNFGYdsRRAALYYP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250056290 149 DFIAYNpkSGKNETFPAPAYACGLRAYIDHEQGWHKSLSNVPVKNVLGMSRHVFWSLQAEDSDANSLNNKEITTIIR--R 226
Cdd:COG3497    79 WVKVFD--TNATVTVPPSGHAAGLYARVDAERGVWKSPSNKEINGVTGLSRPVGFDLQLTDTEANLLNPKGINTIRNfpG 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250056290 227 NGFRFWGNRTPETNA-YIFEVYTRTAQVLADSIAEAQFETIDSPLTPANVKDVISAIRAKLDSLVTAGKLIGAECWYDVV 305
Cdd:COG3497   157 RGFRVWGNRTLSSDPeWRFINVRRTFDFIEESIAEATQWAVDEPNTPALWDDIRESINAFLRTLWRQGALLGGKVWCDEE 236

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 2250056290 306 DNGTTNLRQGRVRIRYKYTPVPPLEDMELYQTFTDEF 342
Cdd:COG3497   237 TNTAEDIAAGKLVIDIGFAPVPPAEFITFRIRQTDGY 273
Phage_sheath_1 pfam04984
Phage tail sheath protein subtilisin-like domain; This entry represents the second domain in a ...
 69-236 1.11e-13

Phage tail sheath protein subtilisin-like domain; This entry represents the second domain in a variety of phage tail sheath proteins. According to ECOD this domain has a subtilisin-like structure.


Pssm-ID: 428236  Cd Length: 157  Bit Score: 67.76  E-value: 1.11e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250056290  69 GSYTGMYALLVAEQDEsiGYRPRILAAP--ELDTEAVTKSLCVIAGKLRAFVYASCHGCNTMAEAITYRQKFN--EREVM 144
Cdd:pfam04984   1 GGVTNPDYLAALAALE--GEKFNLIGLPgdDASDNALATEVQAFVKRWREEEGLKGIAVLAGPGTADYEGIINvsSTYAA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250056290 145 LLWPDFIAYnpksgknetfPAPAYACGLRAYIDHEQGWHKSLSNVPVKNVLGMSRhvfwslQAEDSDANSLNNKEITTII 224
Cdd:pfam04984  79 LDGPYITPY----------PAAAWVAGLIAGADVEESDTARPQNLEVTGALDVAP------RLTNEERNLLLEAGVFTLT 142

                         170
                  ....*....|....
gi 2250056290 225 RR--NGFRFWGNRT 236
Cdd:pfam04984 143 VDagDGVRVEGDIT 156
 
Name Accession Description Interval E-value
FI PHA02560
major tail sheath protein; Provisional
 2-342 3.14e-130

major tail sheath protein; Provisional


Pssm-ID: 164955 [Multi-domain]  Cd Length: 388  Bit Score: 377.51  E-value: 3.14e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250056290   2 FPLNKPTLLTRVNDVLGKCGTTGTLYRALKAIADQVSTKVIVVRVAEHKEEDGKTQDqlVIGGSEDDGSYTGMYALLVAE 81
Cdd:PHA02560   43 FPLNTPVLITNVVDALGKAGAKGTLPRALDAIADQTKPPTVVVRVAEGADEAATTSN--IIGGVDADGKYTGIKALLAAQ 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250056290  82 qdESIGYRPRILAAPELDTEAVTKSLCVIAGKLRAFVYASCHGCNTMAEAITYRQKFNEREVMLLWPDFIAYNPKSGKNE 161
Cdd:PHA02560  121 --NVLGVKPRILGAPGLDTQAVAVALAAMAQKLRAFAYISAPGCKTKEEAAAYRENFGQREVMVIWPDFKVYDTATNATA 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250056290 162 TFPAPAYACGLRAYIDHEQGWHKSLSNVPVKNVLGMSRHVFWSLQAEDSDANSLNNKEITTIIRRNGFRFWGNRT-PETN 240
Cdd:PHA02560  199 TAPASARAAGLRAKIDNDVGWHKSLSNVGVLGVTGISRDVDWDLQDPSTDANLLNENGVTTLVRRNGFRFWGNRTcSDDP 278

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250056290 241 AYIFEVYTRTAQVLADSIAEAQFETIDSPLTPANVKDVISAIRAKLDSLVTAGKLIGAECWYDVVDNGTTNLRQGRVRIR 320
Cdd:PHA02560  279 LFAFENYVRTAQVIADTIAEAHMWAVDKPLTPSLVRDIVEGINAKFRDLVANGYILGGEAWFDPELNTKETLKAGKLYID 358

                         330       340
                  ....*....|....*....|..
gi 2250056290 321 YKYTPVPPLEDMELYQTFTDEF 342
Cdd:PHA02560  359 YDYTPVPPLEHLTFRQRITDRY 380
COG3497 COG3497
Phage tail sheath protein FI [Mobilome: prophages, transposons];
73-342 1.16e-100

Phage tail sheath protein FI [Mobilome: prophages, transposons];


Pssm-ID: 442720 [Multi-domain]  Cd Length: 273  Bit Score: 298.34  E-value: 1.16e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250056290  73 GMYALLVAeqDESIGYRPRILAAPELDT-EAVTKSLCVIAGKLRAFVYASCHG-CNTMAEAITYRQKFNE--REVMLLWP 148
Cdd:COG3497     1 GLEALEAA--DEKLGVKPRILIAPGLSSlPAVAAALLAHCEKLRAFAILDAPGdGTTLADAIAYRGNFGYdsRRAALYYP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250056290 149 DFIAYNpkSGKNETFPAPAYACGLRAYIDHEQGWHKSLSNVPVKNVLGMSRHVFWSLQAEDSDANSLNNKEITTIIR--R 226
Cdd:COG3497    79 WVKVFD--TNATVTVPPSGHAAGLYARVDAERGVWKSPSNKEINGVTGLSRPVGFDLQLTDTEANLLNPKGINTIRNfpG 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250056290 227 NGFRFWGNRTPETNA-YIFEVYTRTAQVLADSIAEAQFETIDSPLTPANVKDVISAIRAKLDSLVTAGKLIGAECWYDVV 305
Cdd:COG3497   157 RGFRVWGNRTLSSDPeWRFINVRRTFDFIEESIAEATQWAVDEPNTPALWDDIRESINAFLRTLWRQGALLGGKVWCDEE 236

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 2250056290 306 DNGTTNLRQGRVRIRYKYTPVPPLEDMELYQTFTDEF 342
Cdd:COG3497   237 TNTAEDIAAGKLVIDIGFAPVPPAEFITFRIRQTDGY 273
Phage_sheath_1 pfam04984
Phage tail sheath protein subtilisin-like domain; This entry represents the second domain in a ...
 69-236 1.11e-13

Phage tail sheath protein subtilisin-like domain; This entry represents the second domain in a variety of phage tail sheath proteins. According to ECOD this domain has a subtilisin-like structure.


Pssm-ID: 428236  Cd Length: 157  Bit Score: 67.76  E-value: 1.11e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250056290  69 GSYTGMYALLVAEQDEsiGYRPRILAAP--ELDTEAVTKSLCVIAGKLRAFVYASCHGCNTMAEAITYRQKFN--EREVM 144
Cdd:pfam04984   1 GGVTNPDYLAALAALE--GEKFNLIGLPgdDASDNALATEVQAFVKRWREEEGLKGIAVLAGPGTADYEGIINvsSTYAA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250056290 145 LLWPDFIAYnpksgknetfPAPAYACGLRAYIDHEQGWHKSLSNVPVKNVLGMSRhvfwslQAEDSDANSLNNKEITTII 224
Cdd:pfam04984  79 LDGPYITPY----------PAAAWVAGLIAGADVEESDTARPQNLEVTGALDVAP------RLTNEERNLLLEAGVFTLT 142

                         170
                  ....*....|....
gi 2250056290 225 RR--NGFRFWGNRT 236
Cdd:pfam04984 143 VDagDGVRVEGDIT 156
Phage_sheath_1C pfam17482
Phage tail sheath C-terminal domain; This entry represents the C-terminal domain in a variety ...
 239-331 2.33e-09

Phage tail sheath C-terminal domain; This entry represents the C-terminal domain in a variety of phage tail sheath proteins.


Pssm-ID: 435922 [Multi-domain]  Cd Length: 104  Bit Score: 54.20  E-value: 2.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250056290 239 TNAYIFEVYTRTAQVLADSIAEA--QFETIDSPLTPANVKDVISAIRAKLDSLVTAGKLIGAECWYDvVDNGTTNLRQGR 316
Cdd:pfam17482   3 DPDFLKNRTIRTLDYVNNDIRSTfkWKYPGKKLNDDDGRALVKSELNAYLRELQSLGAIENFDVECD-VEVNRQGNDKDR 81

                          90
                  ....*....|....*
gi 2250056290 317 VRIRYKYTPVPPLED 331
Cdd:pfam17482  82 VVVNIDVTPVNSMEK 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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