NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2254478174|ref|WP_251648482|]
View 

helix-turn-helix transcriptional regulator [Rummeliibacillus stabekisii]

Protein Classification

ArsR/SmtB family transcription factor( domain architecture ID 10001925)

ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis

Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|28436329|12829264|28512703|30191942|15808743

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
2-90 9.16e-26

DNA-binding transcriptional regulator, ArsR family [Transcription];


:

Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 91.49  E-value: 9.16e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2254478174   2 DLQLMEKQLKAVSDANRLKLLASLKNGEVCVCDLVDILQVSQPAVSQQLRKLKEGDIILERKKGTWKHYRLNDsqtPYIQ 81
Cdd:COG0640     6 ELEELAELFKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLAD---EALA 82


                  ....*....
gi 2254478174  82 AIIDELAPI 90
Cdd:COG0640    83 ELLEWLLEL 91
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
2-90 9.16e-26

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 91.49  E-value: 9.16e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2254478174   2 DLQLMEKQLKAVSDANRLKLLASLKNGEVCVCDLVDILQVSQPAVSQQLRKLKEGDIILERKKGTWKHYRLNDsqtPYIQ 81
Cdd:COG0640     6 ELEELAELFKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLAD---EALA 82


                  ....*....
gi 2254478174  82 AIIDELAPI 90
Cdd:COG0640    83 ELLEWLLEL 91
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 10-74 1.06e-25

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 90.98  E-value: 1.06e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2254478174  10 LKAVSDANRLKLLASLKNGEVCVCDLVDILQVSQPAVSQQLRKLKEGDIILERKKGTWKHYRLND 74
Cdd:NF033788    5 FKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLAD 69
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 10-87 6.70e-20

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 76.57  E-value: 6.70e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2254478174  10 LKAVSDANRLKLLASLKNGEVCVCDLVDILQVSQPAVSQQLRKLKEGDIILERKKGTWKHYRLNDsqTPYIQAIIDEL 87
Cdd:cd00090     1 LKALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTD--AERLLALLESL 76
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
20-76 9.35e-17

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 68.01  E-value: 9.35e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2254478174   20 KLLASLKNGEVCVCDLVDILQVSQPAVSQQLRKLKEGDIILERKKGTWKHYRLNDSQ 76
Cdd:smart00418   1 KILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEK 57
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 3-86 3.00e-13

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 60.60  E-value: 3.00e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2254478174   3 LQLMEKQL-KAVSDANRLKLLASLKN-GEVCVCDLVDILQVSQPAVSQQLRKLKEGDIILERKKGTWKHYRLNDSQTPYI 80
Cdd:PRK10141    2 SFLLPLQLfKILSDETRLGIVLLLREsGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRLSPHIPAWA 81


                  ....*.
gi 2254478174  81 QAIIDE 86
Cdd:PRK10141   82 AKIIEQ 87
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 15-59 7.73e-12

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 55.14  E-value: 7.73e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2254478174  15 DANRLKLLASLKNGEVCVCDLVDILQVSQPAVSQQLRKLKEGDII 59
Cdd:pfam01022   1 DPTRLKILKLLAEGELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
2-90 9.16e-26

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 91.49  E-value: 9.16e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2254478174   2 DLQLMEKQLKAVSDANRLKLLASLKNGEVCVCDLVDILQVSQPAVSQQLRKLKEGDIILERKKGTWKHYRLNDsqtPYIQ 81
Cdd:COG0640     6 ELEELAELFKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLAD---EALA 82


                  ....*....
gi 2254478174  82 AIIDELAPI 90
Cdd:COG0640    83 ELLEWLLEL 91
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 10-74 1.06e-25

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 90.98  E-value: 1.06e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2254478174  10 LKAVSDANRLKLLASLKNGEVCVCDLVDILQVSQPAVSQQLRKLKEGDIILERKKGTWKHYRLND 74
Cdd:NF033788    5 FKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLAD 69
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 10-87 6.70e-20

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 76.57  E-value: 6.70e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2254478174  10 LKAVSDANRLKLLASLKNGEVCVCDLVDILQVSQPAVSQQLRKLKEGDIILERKKGTWKHYRLNDsqTPYIQAIIDEL 87
Cdd:cd00090     1 LKALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTD--AERLLALLESL 76
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
20-76 9.35e-17

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 68.01  E-value: 9.35e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2254478174   20 KLLASLKNGEVCVCDLVDILQVSQPAVSQQLRKLKEGDIILERKKGTWKHYRLNDSQ 76
Cdd:smart00418   1 KILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEK 57
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 3-86 3.00e-13

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 60.60  E-value: 3.00e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2254478174   3 LQLMEKQL-KAVSDANRLKLLASLKN-GEVCVCDLVDILQVSQPAVSQQLRKLKEGDIILERKKGTWKHYRLNDSQTPYI 80
Cdd:PRK10141    2 SFLLPLQLfKILSDETRLGIVLLLREsGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRLSPHIPAWA 81


                  ....*.
gi 2254478174  81 QAIIDE 86
Cdd:PRK10141   82 AKIIEQ 87
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 15-59 7.73e-12

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 55.14  E-value: 7.73e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2254478174  15 DANRLKLLASLKNGEVCVCDLVDILQVSQPAVSQQLRKLKEGDII 59
Cdd:pfam01022   1 DPTRLKILKLLAEGELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
17-90 2.19e-06

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 44.11  E-value: 2.19e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2254478174  17 NRLKLLASLKNGEVCVCDLVDILQVSQPAVSQQLRKLKEGDIIlERKKGTwkhYRLndsqTPYIQAIIDELAPI 90
Cdd:COG4742    17 KRKNILLLLAEGPKTRSELAESLDVSRSTILRQLKELEERGLI-ERDDGE---YEL----TTLGRLVVEEMEPL 82
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
7-65 1.40e-05

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 40.33  E-value: 1.40e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2254478174   7 EKQLKAVSDANRLKLLASLKNGEVCVCDLVDILQVSQPAVSQQLRKLKEGDII-LERKKG 65
Cdd:COG4189    10 LEVLKALASETRLRILRLLAEEPLNVNELAEALGLPKSTVSYHIRKLEEAGLIrTEYKPG 69
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
19-65 7.62e-04

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 36.33  E-value: 7.62e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2254478174  19 LKLLASL--KNGEVCVCDLVDILQVSQPAVSQQLRKLKE-GDIILERKKG 65
Cdd:COG1321    12 LKAIYELseEGGPVRTSDIAERLGVSPPSVTEMLKKLEEkGLVEYEPYGG 61
HTH_1 pfam00126
Bacterial regulatory helix-turn-helix protein, lysR family;
39-65 3.06e-03

Bacterial regulatory helix-turn-helix protein, lysR family;


Pssm-ID: 459683 [Multi-domain]  Cd Length: 60  Bit Score: 33.13  E-value: 3.06e-03
                          10        20
                  ....*....|....*....|....*....
gi 2254478174  39 LQVSQPAVSQQLRKLKE--GDIILERKKG 65
Cdd:pfam00126  23 LGLSQPAVSRQIKRLEEelGVPLFERTTR 51
LysR COG0583
DNA-binding transcriptional regulator, LysR family [Transcription];
39-88 5.75e-03

DNA-binding transcriptional regulator, LysR family [Transcription];


Pssm-ID: 440348 [Multi-domain]  Cd Length: 256  Bit Score: 34.46  E-value: 5.75e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2254478174  39 LQVSQPAVSQQLRKLKE--GDIILERKKgtwKHYRLndsqTP-------YIQAIIDELA 88
Cdd:COG0583    25 LGVSQPAVSRQIRRLEEelGVPLFERTG---RGLRL----TEagerlleRARRILAELE 76
PRK11242 PRK11242
DNA-binding transcriptional regulator CynR; Provisional
 39-55 9.24e-03

DNA-binding transcriptional regulator CynR; Provisional


Pssm-ID: 183051 [Multi-domain]  Cd Length: 296  Bit Score: 33.78  E-value: 9.24e-03
                          10
                  ....*....|....*..
gi 2254478174  39 LQVSQPAVSQQLRKLKE 55
Cdd:PRK11242   25 LHVSQPTLSQQIRQLEE 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH