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Conserved domains on  [gi|2255965691|ref|WP_251941465|]
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carboxypeptidase-like regulatory domain-containing protein [Salinibacter ruber]

Protein Classification

SusC/RagA family TonB-linked outer membrane protein( domain architecture ID 1000763)

SusC/RagA family TonB-linked outer membrane protein

Gene Ontology:  GO:0022857|GO:0009279

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
OMP_RagA_SusC super family cl37378
TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade ...
 27-365 3.23e-104

TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate]


The actual alignment was detected with superfamily member TIGR04056:

Pssm-ID: 274948 [Multi-domain]  Cd Length: 981  Bit Score: 328.40  E-value: 3.23e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255965691  27 TVTGVVTEASsGDTLPGANVVIVDSQRGTSTDANGAYRLTgLEPGtYKVRASFVGFRsrTQEVDVAAGETLelNFALAPD 106
Cdd:TIGR04056   2 TVTGVVVDET-GEPLIGASVVVKGTTNGTITDIDGNFSLK-VPPG-AVLVFSYIGYK--TQEVKVKGQKNL--NITLKED 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255965691 107 AMAMDEMVVVGYGTQERSDLTGSISSVPTEDLAETPIESAQEAIQGRVSGVTVTQNTGSPGSGFSIRIRGTGT-TGNSNP 185
Cdd:TIGR04056  75 TQELDEVVVVGYGTQKKKSLTGAVSTVKAKELKKVPVSNLSNALQGKVAGVIITQSSGEPGGDAEIWIRGISSfGGNNSP 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255965691 186 LYVVDGVPVSDptetgagGISFLNPNDIESIDILKGASAAAIYGAQAANGAVIITTKSGSAGERSISFSAYTGIQQTPRT 265
Cdd:TIGR04056 155 LYVIDGVPRDN-------GLSDLNPEDIESISVLKDASATAIYGSRGANGVILITTKRGKEGKPKISYNAEFGFSTPTRL 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255965691 266 IDMLEGPEYAALRNEANINAGQAP-----------TFTSPSAYLGPegSTDYQDLVFER-GITQNYSLAVSGGTEDLTYR 333
Cdd:TIGR04056 228 PEMLNAYEYAELYNEALLNRGSSPpdiytdeeieaYRNGLDPDLYP--NTDWQDEIFKRtAFNQRHNLSVSGGTEKARYY 305

                         330       340       350
                  ....*....|....*....|....*....|..
gi 2255965691 334 ISGGYFEEGGIIDKSSLERLNARVNTEFEVND 365
Cdd:TIGR04056 306 VSLGYYNEEGILKNSDYKRYNFRANIDAKLTK 337
 
Name Accession Description Interval E-value
OMP_RagA_SusC TIGR04056
TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade ...
 27-365 3.23e-104

TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 274948 [Multi-domain]  Cd Length: 981  Bit Score: 328.40  E-value: 3.23e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255965691  27 TVTGVVTEASsGDTLPGANVVIVDSQRGTSTDANGAYRLTgLEPGtYKVRASFVGFRsrTQEVDVAAGETLelNFALAPD 106
Cdd:TIGR04056   2 TVTGVVVDET-GEPLIGASVVVKGTTNGTITDIDGNFSLK-VPPG-AVLVFSYIGYK--TQEVKVKGQKNL--NITLKED 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255965691 107 AMAMDEMVVVGYGTQERSDLTGSISSVPTEDLAETPIESAQEAIQGRVSGVTVTQNTGSPGSGFSIRIRGTGT-TGNSNP 185
Cdd:TIGR04056  75 TQELDEVVVVGYGTQKKKSLTGAVSTVKAKELKKVPVSNLSNALQGKVAGVIITQSSGEPGGDAEIWIRGISSfGGNNSP 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255965691 186 LYVVDGVPVSDptetgagGISFLNPNDIESIDILKGASAAAIYGAQAANGAVIITTKSGSAGERSISFSAYTGIQQTPRT 265
Cdd:TIGR04056 155 LYVIDGVPRDN-------GLSDLNPEDIESISVLKDASATAIYGSRGANGVILITTKRGKEGKPKISYNAEFGFSTPTRL 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255965691 266 IDMLEGPEYAALRNEANINAGQAP-----------TFTSPSAYLGPegSTDYQDLVFER-GITQNYSLAVSGGTEDLTYR 333
Cdd:TIGR04056 228 PEMLNAYEYAELYNEALLNRGSSPpdiytdeeieaYRNGLDPDLYP--NTDWQDEIFKRtAFNQRHNLSVSGGTEKARYY 305

                         330       340       350
                  ....*....|....*....|....*....|..
gi 2255965691 334 ISGGYFEEGGIIDKSSLERLNARVNTEFEVND 365
Cdd:TIGR04056 306 VSLGYYNEEGILKNSDYKRYNFRANIDAKLTK 337
BtuB COG4206
Outer membrane cobalamin receptor protein BtuB [Coenzyme transport and metabolism];
113-339 1.41e-27

Outer membrane cobalamin receptor protein BtuB [Coenzyme transport and metabolism];


Pssm-ID: 443355 [Multi-domain]  Cd Length: 276  Bit Score: 109.58  E-value: 1.41e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255965691 113 MVVVGYG-TQERSDLTGSISSVPTEDLAETPIESAQEAIQgRVSGVTVTQNtGSPGSGFSIRIRGTGTtgnSNPLYVVDG 191
Cdd:COG4206     1 VVVTATRlEQSKSDLTGSVTVIDAEELERSGATSLADALR-RVPGVQVSSS-GGPGSAASISIRGLGS---NQTLVLIDG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255965691 192 VPVSDPTeTGAGGISFLNPNDIESIDILKGASAAAIYGaQAANGAVIITTKSGSAGER-SISFSA-YTGIQQTPRTIDML 269
Cdd:COG4206    76 VPLNDPS-LGGVDLSLIPPDDIERIEVLKGAASALYGS-DAIGGVINITTKKGKKGFKgSVSASYgSFGTRRLSASLSGG 153

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255965691 270 EGPEYAALRNEANINAGQAPTFTSPSAYLGPEGSTDYQDLVFErgITQNYSLAVSGGTEDLTYRISGGYF 339
Cdd:COG4206   154 AGKFSYSLSASYRRSDGYRYNDPDLRNNDGYENTSLNARLGYK--LGDNGSLSLSGGYSDSERGYPGAVG 221
CarbopepD_reg_2 pfam13715
CarboxypepD_reg-like domain; This domain family is found in bacteria, archaea and eukaryotes, ...
 28-115 8.54e-26

CarboxypepD_reg-like domain; This domain family is found in bacteria, archaea and eukaryotes, and is approximately 90 amino acids in length. The family is found in association with pfam07715 and pfam00593.


Pssm-ID: 433425 [Multi-domain]  Cd Length: 88  Bit Score: 99.20  E-value: 8.54e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255965691  28 VTGVVTEASSGDTLPGANVVIVDSQRGTSTDANGAYRLTGLEPGTYKVRASFVGFRSRTQEVDVAAGETLELNFALAPDA 107
Cdd:pfam13715   1 ISGTVVDENTGEPLPGATVYVKGTTKGTVTDADGNFELKNLPAGTYTLVVSFVGYKTQEKKVTVSNDNTLDVNFLLKEDA 80


                  ....*...
gi 2255965691 108 MAMDEMVV 115
Cdd:pfam13715  81 LLLDEVVV 88
ligand_gated_channel cd01347
TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) ...
 129-262 2.59e-11

TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.


Pssm-ID: 238657 [Multi-domain]  Cd Length: 635  Bit Score: 64.78  E-value: 2.59e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255965691 129 SISSVPTEDLAETPIESAQEAIQgRVSGVTVTQNTGspGSGFSIRIRGTGTTGNsnpLYVVDGVPVSDPTETGAGGISFL 208
Cdd:cd01347     1 SVSVITAEDIEKQPATSLADLLR-RIPGVSVTRGGG--GGGSTISIRGFGPDRT---LVLVDGLPLASSNYGRGVDLNTI 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2255965691 209 NPNDIESIDILKGASAAAIYGAQAAnGAVIITTKSGSAgERSISFSAYTGIQQT 262
Cdd:cd01347    75 PPELIERVEVLKGPSSALYGSGAIG-GVVNIITKRPTD-EFGGSVTAGYGSDNS 126
PRK13484 PRK13484
IreA family TonB-dependent siderophore receptor;
111-221 1.61e-04

IreA family TonB-dependent siderophore receptor;


Pssm-ID: 139605 [Multi-domain]  Cd Length: 682  Bit Score: 43.84  E-value: 1.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255965691 111 DEMVVVGYG-TQERSDLTGSISSVPTEDLAETPIESAQEAIQGrVSGVTVTQNTGSPgsgfSIRIRgtGTTGNSNpLYVV 189
Cdd:PRK13484   31 DTLVVTASGfTQQLRNAPASVSVITSEQLQKKPVSDLVDAVKD-VEGISITGGNEKP----DISIR--GLSGDYT-LILV 102

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2255965691 190 DGVPVS--DPTETGAGGIS--FLNPND-IESIDILKG 221
Cdd:PRK13484  103 DGRRQSgrESRPNGSGGFEagFIPPVEaIERIEVIRG 139
 
Name Accession Description Interval E-value
OMP_RagA_SusC TIGR04056
TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade ...
 27-365 3.23e-104

TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 274948 [Multi-domain]  Cd Length: 981  Bit Score: 328.40  E-value: 3.23e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255965691  27 TVTGVVTEASsGDTLPGANVVIVDSQRGTSTDANGAYRLTgLEPGtYKVRASFVGFRsrTQEVDVAAGETLelNFALAPD 106
Cdd:TIGR04056   2 TVTGVVVDET-GEPLIGASVVVKGTTNGTITDIDGNFSLK-VPPG-AVLVFSYIGYK--TQEVKVKGQKNL--NITLKED 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255965691 107 AMAMDEMVVVGYGTQERSDLTGSISSVPTEDLAETPIESAQEAIQGRVSGVTVTQNTGSPGSGFSIRIRGTGT-TGNSNP 185
Cdd:TIGR04056  75 TQELDEVVVVGYGTQKKKSLTGAVSTVKAKELKKVPVSNLSNALQGKVAGVIITQSSGEPGGDAEIWIRGISSfGGNNSP 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255965691 186 LYVVDGVPVSDptetgagGISFLNPNDIESIDILKGASAAAIYGAQAANGAVIITTKSGSAGERSISFSAYTGIQQTPRT 265
Cdd:TIGR04056 155 LYVIDGVPRDN-------GLSDLNPEDIESISVLKDASATAIYGSRGANGVILITTKRGKEGKPKISYNAEFGFSTPTRL 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255965691 266 IDMLEGPEYAALRNEANINAGQAP-----------TFTSPSAYLGPegSTDYQDLVFER-GITQNYSLAVSGGTEDLTYR 333
Cdd:TIGR04056 228 PEMLNAYEYAELYNEALLNRGSSPpdiytdeeieaYRNGLDPDLYP--NTDWQDEIFKRtAFNQRHNLSVSGGTEKARYY 305

                         330       340       350
                  ....*....|....*....|....*....|..
gi 2255965691 334 ISGGYFEEGGIIDKSSLERLNARVNTEFEVND 365
Cdd:TIGR04056 306 VSLGYYNEEGILKNSDYKRYNFRANIDAKLTK 337
BtuB COG4206
Outer membrane cobalamin receptor protein BtuB [Coenzyme transport and metabolism];
113-339 1.41e-27

Outer membrane cobalamin receptor protein BtuB [Coenzyme transport and metabolism];


Pssm-ID: 443355 [Multi-domain]  Cd Length: 276  Bit Score: 109.58  E-value: 1.41e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255965691 113 MVVVGYG-TQERSDLTGSISSVPTEDLAETPIESAQEAIQgRVSGVTVTQNtGSPGSGFSIRIRGTGTtgnSNPLYVVDG 191
Cdd:COG4206     1 VVVTATRlEQSKSDLTGSVTVIDAEELERSGATSLADALR-RVPGVQVSSS-GGPGSAASISIRGLGS---NQTLVLIDG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255965691 192 VPVSDPTeTGAGGISFLNPNDIESIDILKGASAAAIYGaQAANGAVIITTKSGSAGER-SISFSA-YTGIQQTPRTIDML 269
Cdd:COG4206    76 VPLNDPS-LGGVDLSLIPPDDIERIEVLKGAASALYGS-DAIGGVINITTKKGKKGFKgSVSASYgSFGTRRLSASLSGG 153

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255965691 270 EGPEYAALRNEANINAGQAPTFTSPSAYLGPEGSTDYQDLVFErgITQNYSLAVSGGTEDLTYRISGGYF 339
Cdd:COG4206   154 AGKFSYSLSASYRRSDGYRYNDPDLRNNDGYENTSLNARLGYK--LGDNGSLSLSGGYSDSERGYPGAVG 221
CirA COG1629
Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];
110-365 7.52e-27

Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];


Pssm-ID: 441236 [Multi-domain]  Cd Length: 644  Bit Score: 111.84  E-value: 7.52e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255965691 110 MDEMVVVGYGTQER-SDLTGSISSVPTEDLAETPIESAQEAIQgRVSGVTVTQNTGSpgsGFSIRIRGTGTTGNsNPLYV 188
Cdd:COG1629     1 LEEVVVTATRTDESlQDVPGSVSVISREQLEDQPATDLGDLLR-RVPGVSVTSAGGG---AGQISIRGFGGGGN-RVLVL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255965691 189 VDGVPVSDPtETGAGGISFLNPNDIESIDILKGASaAAIYGAQAANGAVIITTKSGSAGeRSISFSAYTGiqqtprtidm 268
Cdd:COG1629    76 VDGVPLNDP-SGGDGGLSYIDPEDIERVEVLRGPS-SALYGSGALGGVINIVTKKPKDG-KGGEVSASYG---------- 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255965691 269 legpeyaalrneaNINagqaptftspsaylgpegstdyqdlvfergiTQNYSLAVSGGTEDLTYRISGGYFEEGGIIDKS 348
Cdd:COG1629   143 -------------SYG-------------------------------TYRASLSLSGGNGKLAYRLSASYRDSDGYRDNS 178

                         250
                  ....*....|....*..
gi 2255965691 349 SLERLNARVNTEFEVND 365
Cdd:COG1629   179 DSDRYNLRAKLGYQLGD 195
CarbopepD_reg_2 pfam13715
CarboxypepD_reg-like domain; This domain family is found in bacteria, archaea and eukaryotes, ...
 28-115 8.54e-26

CarboxypepD_reg-like domain; This domain family is found in bacteria, archaea and eukaryotes, and is approximately 90 amino acids in length. The family is found in association with pfam07715 and pfam00593.


Pssm-ID: 433425 [Multi-domain]  Cd Length: 88  Bit Score: 99.20  E-value: 8.54e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255965691  28 VTGVVTEASSGDTLPGANVVIVDSQRGTSTDANGAYRLTGLEPGTYKVRASFVGFRSRTQEVDVAAGETLELNFALAPDA 107
Cdd:pfam13715   1 ISGTVVDENTGEPLPGATVYVKGTTKGTVTDADGNFELKNLPAGTYTLVVSFVGYKTQEKKVTVSNDNTLDVNFLLKEDA 80


                  ....*...
gi 2255965691 108 MAMDEMVV 115
Cdd:pfam13715  81 LLLDEVVV 88
FepA COG4771
Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and ...
 96-365 2.04e-21

Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism];


Pssm-ID: 443803 [Multi-domain]  Cd Length: 612  Bit Score: 95.69  E-value: 2.04e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255965691  96 TLELNFALAPDAMAMDEMVVVGYGT-QERSDLTGSISSVPTEDLAETPIESAQEAIQgRVSGVTVTQNTGSPGSGfSIRI 174
Cdd:COG4771    13 AAQAADALAEDATELEEVVVTATRTeQSLSDAPASVSVITAEEIEKLGATDLADALR-LLPGVSVTRSGGRGGSS-GISI 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255965691 175 RGTGTtgnSNPLYVVDGVPVSDPTETGAGGISFLNPNDIESIDILKGASaAAIYGAQAANGAVIITTKSGSagersisfs 254
Cdd:COG4771    91 RGLGG---DRVLVLIDGVPVNNPALGGGGDLSYIPPDDIERIEVIRGPA-SALYGSDAIGGVINIITKKPT--------- 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255965691 255 aytgiqqtprtiDMLEGpeyaalrnEANINAGQAPTFtspsaylgpegstdyqdlvfergiTQNYSLAVSGGTEDLTYRI 334
Cdd:COG4771   158 ------------DELEG--------SVSLGYGSNGNG------------------------TYSGSLSLGGPGDKLSFLL 193

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 2255965691 335 SGGYFEEGGIIDK--------SSLERLNARVNTEFEVND 365
Cdd:COG4771   194 SGSYRDRDGYLDYrnggfvgnSGYERYNLNAKLGYRLSD 232
CarboxypepD_reg pfam13620
Carboxypeptidase regulatory-like domain;
27-103 3.74e-17

Carboxypeptidase regulatory-like domain;


Pssm-ID: 433354 [Multi-domain]  Cd Length: 81  Bit Score: 75.39  E-value: 3.74e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255965691  27 TVTGVVTEASsGDTLPGANVVIVD----SQRGTSTDANGAYRLTGLEPGTYKVRASFVGFRSRTQE-VDVAAGETLELNF 101
Cdd:pfam13620   1 TISGTVTDPS-GAPVPGATVTVTNtdtgTVRTTTTDADGRYRFPGLPPGTYTVTVSAPGFKTATRTgVTVTAGQTTTLDV 79


                  ..
gi 2255965691 102 AL 103
Cdd:pfam13620  80 TL 81
Plug pfam07715
TonB-dependent Receptor Plug Domain; The Plug domain has been shown to be an independently ...
 124-223 1.33e-15

TonB-dependent Receptor Plug Domain; The Plug domain has been shown to be an independently folding subunit of the TonB-dependent receptors. It acts as the channel gate, blocking the pore until the channel is bound by ligand. At this point it under goes conformational changes opens the channel.


Pssm-ID: 462243 [Multi-domain]  Cd Length: 107  Bit Score: 71.92  E-value: 1.33e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255965691 124 SDLTGSISSVPTEDLAETPIESAQEAIQgRVSGVTVTQNTGspGSGFSIRIRGTGTtgnSNPLYVVDGVPVSDPTeTGAG 203
Cdd:pfam07715   3 RDTPGSVSVVTAEDIEDQGATNLADALR-GVPGVSVSSGGG--GGGSSISIRGFGS---NRVLVLVDGVPLNSGG-GGSV 75

                          90       100
                  ....*....|....*....|
gi 2255965691 204 GISFLNPNDIESIDILKGAS 223
Cdd:pfam07715  76 DLNSIDPEDIERVEVLKGPA 95
ligand_gated_channel cd01347
TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) ...
 129-262 2.59e-11

TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.


Pssm-ID: 238657 [Multi-domain]  Cd Length: 635  Bit Score: 64.78  E-value: 2.59e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255965691 129 SISSVPTEDLAETPIESAQEAIQgRVSGVTVTQNTGspGSGFSIRIRGTGTTGNsnpLYVVDGVPVSDPTETGAGGISFL 208
Cdd:cd01347     1 SVSVITAEDIEKQPATSLADLLR-RIPGVSVTRGGG--GGGSTISIRGFGPDRT---LVLVDGLPLASSNYGRGVDLNTI 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2255965691 209 NPNDIESIDILKGASAAAIYGAQAAnGAVIITTKSGSAgERSISFSAYTGIQQT 262
Cdd:cd01347    75 PPELIERVEVLKGPSSALYGSGAIG-GVVNIITKRPTD-EFGGSVTAGYGSDNS 126
FecA COG4772
Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism];
93-223 5.77e-11

Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism];


Pssm-ID: 443804 [Multi-domain]  Cd Length: 681  Bit Score: 63.79  E-value: 5.77e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255965691  93 AGETLELNFALAPDAMAMDEMVVVGYGTQERS--DLTGSISSVPTEDLAETPIESAQEAIQgRVSGVTVTQNTGSpGSGF 170
Cdd:COG4772     6 AAALLLAAAAAAEAATTLETVVVTGSRAAEARlkDVPGSVSVVDREELENQAATSLREVLR-RVPGVNVQEEDGF-GLRP 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2255965691 171 SIRIRGTGTTGNSNPLYVVDGVPVSDPTETGAGGISFLNPNDIESIDILKGAS 223
Cdd:COG4772    84 NIGIRGLGPRRSRGITLLEDGIPIAPAPYGDPAAYYFPDLERMERIEVLRGAA 136
TonB-siderophor TIGR01783
TonB-dependent siderophore receptor; This subfamily model encompasses a wide variety of ...
 125-333 3.13e-08

TonB-dependent siderophore receptor; This subfamily model encompasses a wide variety of TonB-dependent outer membrane siderophore receptors. It has no overlap with TonB receptors known to transport other substances, but is likely incomplete due to lack of characterizations. It is likely that genuine siderophore receptors will be identified which score below the noise cutoff to this model at which point the model should be updated. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins]


Pssm-ID: 273805 [Multi-domain]  Cd Length: 651  Bit Score: 55.50  E-value: 3.13e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255965691 125 DLTGSISSVPTEDLAETPIESAQEAIQgRVSGVTVTQNTGSpGSGFSIRIRGTGTTGNSNPLYVvDGVPVsdpteTGAGG 204
Cdd:TIGR01783   1 DIPQSVSVITRQELEDQQAGSLSEALQ-RVPGVVVGGSGGT-TQFGNITIRGFGLEVDIDNVYL-DGVPL-----LSRGN 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255965691 205 ISFLNPNDIESIDILKGASAAAIYGAQAaNGAVIITTKSGSaGERSISFSAYTGIQQTPRTIDMLEGP----EYAALRNE 280
Cdd:TIGR01783  73 LAIVDPAMVERVEVLRGPASLLYGGSAP-GGVINIVTKRPQ-DEPKGSVTFGAGTRSGYRTAFDLGGPlgadGTFRGRLN 150

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2255965691 281 AN--------INAGQAPTFTSPSAYLGPEGST------DYQDlvfERGITQNYSLAVSGGTEDLTYR 333
Cdd:TIGR01783 151 GArqdgdsfyDGAGEETRLGATATDWQLDDRTllrlgaYYQK---ERDRGGYGGLPASGGTSGRDLS 214
TonB-hemin TIGR01785
TonB-dependent heme/hemoglobin receptor family protein; This model represents the ...
 110-223 6.05e-08

TonB-dependent heme/hemoglobin receptor family protein; This model represents the TonB-dependent outer membrane heme/hemoglobin receptor/transporter found in bacteria which live in contact with animals (which contain hemoglobin or other heme-bearing globins) or legumes (which contain leghemoglobin). Some species having hits to this model such as Nostoc, Caulobacter and Chlorobium do not have an obvious source of hemoglobin-like proteins in their biological niche and so the possibility exists that they act on some other substance. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins]


Pssm-ID: 273807 [Multi-domain]  Cd Length: 665  Bit Score: 54.32  E-value: 6.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255965691 110 MDEMVVVGYGTQERSDLT-GSISSVPTEDLAETPIESAQEAIQgRVSGVTVTQNTGSPGSgfSIRIRGTGTTGnsnPLYV 188
Cdd:TIGR01785   1 LDTVTVTATRTRQVLSEApASVSVISGEQIESKQANNLADALN-TVPGVDVTGGGRPPGQ--SINIRGLQDNR---VLVV 74

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2255965691 189 VDGVPVSDPTETGAGGISFLNPNDIESIDILKGAS 223
Cdd:TIGR01785  75 VDGARQNYQRGGAHNGSLFVDPELLKRIEIVKGPS 109
FhuE COG4773
Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion ...
 91-223 1.83e-06

Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism];


Pssm-ID: 443805 [Multi-domain]  Cd Length: 692  Bit Score: 49.89  E-value: 1.83e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255965691  91 VAAGETLELNFALAPDAMAMDEMVVVGYGTQERSDLTG-----------------SISSVPTEDLAETPIESAQEAIQgR 153
Cdd:COG4773    13 AAAGALAQAAAAAAAEATTLPEVTVTGTAEGTGGYTAKssstatkldtplretpqSVSVVTRQLIEDQGATTLDDALR-N 91

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255965691 154 VSGVTVTQNTGSPGSGFSIRirgtgttGNSNPLYVVDGVPVsdptetGAGGISFLNPNDIESIDILKGAS 223
Cdd:COG4773    92 VPGVTVSSYDGGGRDSFSIR-------GFSIDNYLRDGLPL------GGFGGGQPDTANLERVEVLKGPA 148
Peptidase_M14NE-CP-C_like cd11308
Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, ...
 28-103 1.87e-06

Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; This domain is found C-terminal to the M14 carboxypeptidase (CP) N/E subfamily containing zinc-binding enzymes that hydrolyze single C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key determinant of specificity. The N/E subfamily includes enzymatically active members (carboxypeptidase N, E, M, D, and Z), as well as non-active members (carboxypeptidase-like protein 1, -2, aortic CP-like protein, and adipocyte enhancer binding protein-1) which lack the critical active site and substrate-binding residues considered necessary for activity. The active N/E enzymes fulfill a variety of cellular functions, including prohormone processing, regulation of peptide hormone activity, alteration of protein-protein or protein-cell interactions and transcriptional regulation. For M14 CPs, it has been suggested that this domain may assist in folding of the CP domain, regulate enzyme activity, or be involved in interactions with other proteins or with membranes; for carboxypeptidase M, it may interact with the bradykinin 1 receptor at the cell surface. This domain may also be found in other peptidase families.


Pssm-ID: 200604 [Multi-domain]  Cd Length: 76  Bit Score: 45.21  E-value: 1.87e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2255965691  28 VTGVVTEASsGDTLPGANVVIVDSQRGTSTDANGAY-RLtgLEPGTYKVRASFVGFRSRTQEVDVAAG-ETLELNFAL 103
Cdd:cd11308     2 IKGFVTDAT-GNPIANATISVEGINHDVTTAKDGDYwRL--LLPGTYNVTASAPGYQPVTKTVTVPNNfSATVVNFTL 76
Fiu COG4774
Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism];
129-223 3.07e-06

Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism];


Pssm-ID: 443806 [Multi-domain]  Cd Length: 639  Bit Score: 49.11  E-value: 3.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255965691 129 SISSVPTEDLAETPIESAQEAIQgRVSGVTVTQNTGspGSGFSIRIRGTGTTGNsnplYVVDGVPVsdptetgaGGISFL 208
Cdd:COG4774    12 SVTVVTRELIEDQGATSLADALR-NVPGVTFGAGEG--GNGDSFSIRGFSASGD----IYVDGLRD--------PGQYRR 76

                          90
                  ....*....|....*
gi 2255965691 209 NPNDIESIDILKGAS 223
Cdd:COG4774    77 DTFNLERVEVLKGPA 91
PRK13484 PRK13484
IreA family TonB-dependent siderophore receptor;
111-221 1.61e-04

IreA family TonB-dependent siderophore receptor;


Pssm-ID: 139605 [Multi-domain]  Cd Length: 682  Bit Score: 43.84  E-value: 1.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255965691 111 DEMVVVGYG-TQERSDLTGSISSVPTEDLAETPIESAQEAIQGrVSGVTVTQNTGSPgsgfSIRIRgtGTTGNSNpLYVV 189
Cdd:PRK13484   31 DTLVVTASGfTQQLRNAPASVSVITSEQLQKKPVSDLVDAVKD-VEGISITGGNEKP----DISIR--GLSGDYT-LILV 102

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2255965691 190 DGVPVS--DPTETGAGGIS--FLNPND-IESIDILKG 221
Cdd:PRK13484  103 DGRRQSgrESRPNGSGGFEagFIPPVEaIERIEVIRG 139
PRK13528 PRK13528
outer membrane receptor FepA; Provisional
 91-242 3.10e-04

outer membrane receptor FepA; Provisional


Pssm-ID: 237413 [Multi-domain]  Cd Length: 727  Bit Score: 42.82  E-value: 3.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255965691  91 VAAGETLELNFALAPDAMAMDEMVVVGYGTQERSDLTGsISSVPTEDLAETPIESAQEAIQGRVSGVTVTQN--TGSPGS 168
Cdd:PRK13528   15 LLVGLNSPVSAAESSDDDNGETMVVEATAEQELKQQPG-VSIITAEDIKKRPPVNDLSDIIRKMPGVNLTGNsaSGTRGN 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255965691 169 GFSIRIRGTGTtgnSNPLYVVDGVPVS---------DPTETGAGGISFLNPNDIESIDILKGASAAAIYGaQAANGAVII 239
Cdd:PRK13528   94 NRQIDIRGMGP---ENTLILIDGVPVTsrnsvryswRGERDTRGDTNWVPPEMVERIEVIRGPAAARYGS-GAAGGVVNI 169


                  ...
gi 2255965691 240 TTK 242
Cdd:PRK13528  170 ITK 172
SusC_RagA_signa TIGR04057
TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; This model ...
 212-242 7.02e-04

TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; This model describes a 31-residue signature region of the SusC/RagA family of outer membrane proteins from the Bacteriodetes. While many TonB-dependent outer membrane receptors are associated with siderophore import, this family seems to include generalized nutrient receptors that may convey fairly large oligomers of protein or carbohydrate. This family occurs in high copy numbers in the most abundant species of the human gut microbiome.


Pssm-ID: 274949 [Multi-domain]  Cd Length: 31  Bit Score: 36.79  E-value: 7.02e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 2255965691 212 DIESIDILKGASAAAIYGAQAANGAVIITTK 242
Cdd:TIGR04057   1 DIESISVLKDASAAAIYGSRGANGVILITTK 31
ClfA COG4932
Clumping factor A-related surface protein, MSCRAMM (microbial surface components recognizing ...
 19-76 1.91e-03

Clumping factor A-related surface protein, MSCRAMM (microbial surface components recognizing adhesive matrix molecules) family, DEv-IgG fold [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443959 [Multi-domain]  Cd Length: 689  Bit Score: 40.34  E-value: 1.91e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2255965691  19 GSVTAQTGTVTGVVTEASSGDTLPGANVVIVDSQ-------RGTSTDANGAYRLTGLEPGTYKVR 76
Cdd:COG4932   255 NTPKYTKGSVTVTKTDADTGEPLAGATFTLTDADgntvvttTVTVTDADGSYTFTDLPPGTYTVT 319
SdrD_B pfam17210
SdrD B-like domain; This family corresponds to the B-like domain from the SdrD protein. This ...
 55-78 3.74e-03

SdrD B-like domain; This family corresponds to the B-like domain from the SdrD protein. This domain has three calcium binding sites within a greek key beta sandwich fold.


Pssm-ID: 435789 [Multi-domain]  Cd Length: 112  Bit Score: 36.81  E-value: 3.74e-03
                          10        20
                  ....*....|....*....|....
gi 2255965691  55 TSTDANGAYRLTGLEPGTYKVRAS 78
Cdd:pfam17210  42 TTTDANGKYLFTNLAPGTYYVEFT 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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