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Conserved domains on  [gi|2255991616|ref|WP_251963002|]
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tetratricopeptide repeat protein [Salinibacter ruber]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11419012)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
118-265 4.14e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 61.56  E-value: 4.14e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255991616 118 EDAIGHLKRATEINGTMADAWALLSGCYgQMMGMNPmqgmslgpKANEAMKRAKEHGPNNPRVWIIDGTSDFYTpgmfgG 197
Cdd:COG0457    25 EEAIEDYEKALELDPDDAEALYNLGLAY-LRLGRYE--------EALADYEQALELDPDDAEALNNLGLALQAL-----G 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2255991616 198 DKEKALTKFEKAARLaeqgSPDDplmpgwghAEAHAWVGVAHMEAERYDPARTAFEAALDLNPDYGWV 265
Cdd:COG0457    91 RYEEALEDYDKALEL----DPDD--------AEALYNLGLALLELGRYDEAIEAYERALELDPDDADA 146
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
118-265 4.14e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 61.56  E-value: 4.14e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255991616 118 EDAIGHLKRATEINGTMADAWALLSGCYgQMMGMNPmqgmslgpKANEAMKRAKEHGPNNPRVWIIDGTSDFYTpgmfgG 197
Cdd:COG0457    25 EEAIEDYEKALELDPDDAEALYNLGLAY-LRLGRYE--------EALADYEQALELDPDDAEALNNLGLALQAL-----G 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2255991616 198 DKEKALTKFEKAARLaeqgSPDDplmpgwghAEAHAWVGVAHMEAERYDPARTAFEAALDLNPDYGWV 265
Cdd:COG0457    91 RYEEALEDYDKALEL----DPDD--------AEALYNLGLALLELGRYDEAIEAYERALELDPDDADA 146
TPR_2 pfam07719
Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats ...
 229-261 4.45e-05

Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by pfam00515.


Pssm-ID: 429619 [Multi-domain]  Cd Length: 33  Bit Score: 39.81  E-value: 4.45e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2255991616 229 AEAHAWVGVAHMEAERYDPARTAFEAALDLNPD 261
Cdd:pfam07719   1 AEALYNLGLAYYKLGDYEEALEAYEKALELDPN 33
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 110-274 1.71e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 42.76  E-value: 1.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255991616 110 EARRGRViEDAIGHLKRATEINGTmADAWALLSGCYGQMMGmNPMQGMSLgpkANEAMKRAkehgPNNPRVWIIDGTSDF 189
Cdd:TIGR02917 543 YLRTGNE-EEAVAWLEKAAELNPQ-EIEPALALAQYYLGKG-QLKKALAI---LNEAADAA----PDSPEAWLMLGRAQL 612

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255991616 190 YTpgmfgGDKEKALTKFEKAARLAeqgsPDdplmpgwgHAEAHAWVGVAHMEAERYDPARTAFEAALDLNPDYgWVKKVL 269
Cdd:TIGR02917 613 AA-----GDLNKAVSSFKKLLALQ----PD--------SALALLLLADAYAVMKNYAKAITSLKRALELKPDN-TEAQIG 674


                  ....*
gi 2255991616 270 LPKLE 274
Cdd:TIGR02917 675 LAQLL 679
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
118-265 4.14e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 61.56  E-value: 4.14e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255991616 118 EDAIGHLKRATEINGTMADAWALLSGCYgQMMGMNPmqgmslgpKANEAMKRAKEHGPNNPRVWIIDGTSDFYTpgmfgG 197
Cdd:COG0457    25 EEAIEDYEKALELDPDDAEALYNLGLAY-LRLGRYE--------EALADYEQALELDPDDAEALNNLGLALQAL-----G 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2255991616 198 DKEKALTKFEKAARLaeqgSPDDplmpgwghAEAHAWVGVAHMEAERYDPARTAFEAALDLNPDYGWV 265
Cdd:COG0457    91 RYEEALEDYDKALEL----DPDD--------AEALYNLGLALLELGRYDEAIEAYERALELDPDDADA 146
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 111-262 1.12e-09

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 58.85  E-value: 1.12e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255991616 111 ARRGRViEDAIGHLKRATEINGTMADAWALLSGCYgqmmgmnpmQGMSLGPKANEAMKRAKEHGPNNPRVWIIDGTSdfy 190
Cdd:COG3914    89 QALGRY-EEALALYRRALALNPDNAEALFNLGNLL---------LALGRLEEALAALRRALALNPDFAEAYLNLGEA--- 155

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2255991616 191 tpGMFGGDKEKALTKFEKAARLAeqgsPDdplmpgwgHAEAHAWVGVAHMEAERYDPARTAFEAALDLNPDY 262
Cdd:COG3914   156 --LRRLGRLEEAIAALRRALELD----PD--------NAEALNNLGNALQDLGRLEEAIAAYRRALELDPDN 213
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 119-261 3.67e-09

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 53.86  E-value: 3.67e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255991616 119 DAIGHLKRATEINGTMADAWALLSGCYgqmmgmnpmqgMSLG--PKANEAMKRAKEHGPNNPRVWIIDGTSDFYTpgmfg 196
Cdd:COG4235     1 EAIARLRQALAANPNDAEGWLLLGRAY-----------LRLGryDEALAAYEKALRLDPDNADALLDLAEALLAA----- 64

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2255991616 197 GDKEKALTKFEKAARLaeqgspdDPlmpgwGHAEAHAWVGVAHMEAERYDPARTAFEAALDLNPD 261
Cdd:COG4235    65 GDTEEAEELLERALAL-------DP-----DNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPA 117
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 162-262 9.53e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 50.19  E-value: 9.53e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255991616 162 KANEAMKRAKEHGPNNPRVWIIDGTSDFYTpgmfgGDKEKALTKFEKAARLAeqgsPDDPlmpgwghaEAHAWVGVAHME 241
Cdd:COG4783    22 EAEALLEKALELDPDNPEAFALLGEILLQL-----GDLDEAIVLLHEALELD----PDEP--------EARLNLGLALLK 84

                          90       100
                  ....*....|....*....|.
gi 2255991616 242 AERYDPARTAFEAALDLNPDY 262
Cdd:COG4783    85 AGDYDEALALLEKALKLDPEH 105
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 118-262 6.30e-07

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 47.88  E-value: 6.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255991616 118 EDAIGHLKRATEINGTMADAWALLSGCYgQMMGMNPmqgmslgpKANEAMKRAKEHGPNNPRVWIIDGTSDFYTpgmfgG 197
Cdd:COG4783    21 DEAEALLEKALELDPDNPEAFALLGEIL-LQLGDLD--------EAIVLLHEALELDPDEPEARLNLGLALLKA-----G 86

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2255991616 198 DKEKALTKFEKAARLAEQgspddplmpgwgHAEAHAWVGVAHMEAERYDPARTAFEAALDLNPDY 262
Cdd:COG4783    87 DYDEALALLEKALKLDPE------------HPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 112-262 2.84e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 47.42  E-value: 2.84e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255991616 112 RRGRViEDAIGHLKRATEINGTMADAWALLSGCYgqmmgmnpmqgMSLG--PKANEAMKRAKEHGPNNPRVWIIDGtsDF 189
Cdd:COG2956    54 RRGEY-DRAIRIHQKLLERDPDRAEALLELAQDY-----------LKAGllDRAEELLEKLLELDPDDAEALRLLA--EI 119

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2255991616 190 YtpgMFGGDKEKALTKFEKAARLAEQgspddplmpgwghaEAHAWV--GVAHMEAERYDPARTAFEAALDLNPDY 262
Cdd:COG2956   120 Y---EQEGDWEKAIEVLERLLKLGPE--------------NAHAYCelAELYLEQGDYDEAIEALEKALKLDPDC 177
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
197-265 5.90e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 46.54  E-value: 5.90e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2255991616 197 GDKEKALTKFEKAARLaeqgspdDPlmpgwGHAEAHAWVGVAHMEAERYDPARTAFEAALDLNPDYGWV 265
Cdd:COG0457    22 GRYEEAIEDYEKALEL-------DP-----DDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEA 78
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
118-262 1.92e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 45.00  E-value: 1.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255991616 118 EDAIGHLKRATEINGTMADAWALLSGCYgqmmgmnpmqgMSLG--PKANEAMKRAKEHGPNNPRVWIIDGTSDFYTpgmf 195
Cdd:COG0457    59 EEALADYEQALELDPDDAEALNNLGLAL-----------QALGryEEALEDYDKALELDPDDAEALYNLGLALLEL---- 123

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2255991616 196 gGDKEKALTKFEKAARLaeqgspdDPlmpgwGHAEAHAWVGVAHMEAERYDPARTAFEAALDLNPDY 262
Cdd:COG0457   124 -GRYDEAIEAYERALEL-------DP-----DDADALYNLGIALEKLGRYEEALELLEKLEAAALAA 177
TPR_2 pfam07719
Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats ...
 229-261 4.45e-05

Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by pfam00515.


Pssm-ID: 429619 [Multi-domain]  Cd Length: 33  Bit Score: 39.81  E-value: 4.45e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2255991616 229 AEAHAWVGVAHMEAERYDPARTAFEAALDLNPD 261
Cdd:pfam07719   1 AEALYNLGLAYYKLGDYEEALEAYEKALELDPN 33
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 108-262 4.63e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 43.95  E-value: 4.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255991616 108 EDEARRGRViEDAIGHLKRATEINGTMADAWALLSGCYgQMMGMnpmqgmslGPKANEAMKRAKEHGPNNPRVWIIDGTS 187
Cdd:COG2956    84 QDYLKAGLL-DRAEELLEKLLELDPDDAEALRLLAEIY-EQEGD--------WEKAIEVLERLLKLGPENAHAYCELAEL 153

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2255991616 188 DFYTpgmfgGDKEKALTKFEKAARLaeqgspdDPlmpgwGHAEAHAWVGVAHMEAERYDPARTAFEAALDLNPDY 262
Cdd:COG2956   154 YLEQ-----GDYDEAIEALEKALKL-------DP-----DCARALLLLAELYLEQGDYEEAIAALERALEQDPDY 211
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
197-265 5.49e-05

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 43.37  E-value: 5.49e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2255991616 197 GDKEKALTKFEKAARLaeqgspdDPlmpgwGHAEAHAWVGVAHMEAERYDPARTAFEAALDLNPDYGWV 265
Cdd:COG4785    87 GDYDLAIADFDQALEL-------DP-----DLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYA 143
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 162-260 5.60e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 42.64  E-value: 5.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255991616 162 KANEAMKRAKEHGPNNPRVWIIDGTSDFYTpgmfgGDKEKALTKFEKAARLAeqgsPDDPlmpgwghaEAHAWVGVAHME 241
Cdd:COG5010    72 ESLALLEQALQLDPNNPELYYNLALLYSRS-----GDKDEAKEYYEKALALS----PDNP--------NAYSNLAALLLS 134

                          90
                  ....*....|....*....
gi 2255991616 242 AERYDPARTAFEAALDLNP 260
Cdd:COG5010   135 LGQDDEAKAALQRALGTSP 153
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 197-270 5.92e-05

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 41.52  E-value: 5.92e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2255991616 197 GDKEKALTKFEKAARLAeqgsPDDPLMPgwghaEAHAWVGVAHMEAERYDPARTAFEAALDLNPDYGWVKKVLL 270
Cdd:COG1729     7 GDYDEAIAAFKAFLKRY----PNSPLAP-----DALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKAPDALL 71
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 110-274 1.71e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 42.76  E-value: 1.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255991616 110 EARRGRViEDAIGHLKRATEINGTmADAWALLSGCYGQMMGmNPMQGMSLgpkANEAMKRAkehgPNNPRVWIIDGTSDF 189
Cdd:TIGR02917 543 YLRTGNE-EEAVAWLEKAAELNPQ-EIEPALALAQYYLGKG-QLKKALAI---LNEAADAA----PDSPEAWLMLGRAQL 612

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255991616 190 YTpgmfgGDKEKALTKFEKAARLAeqgsPDdplmpgwgHAEAHAWVGVAHMEAERYDPARTAFEAALDLNPDYgWVKKVL 269
Cdd:TIGR02917 613 AA-----GDLNKAVSSFKKLLALQ----PD--------SALALLLLADAYAVMKNYAKAITSLKRALELKPDN-TEAQIG 674


                  ....*
gi 2255991616 270 LPKLE 274
Cdd:TIGR02917 675 LAQLL 679
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 118-261 1.74e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 42.02  E-value: 1.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255991616 118 EDAIGHLKRATEINGTMADAWALLSGCYGQmmgmnpmQGMSlgPKANEAMKRAKEHGPNNPRVWIIDGtsDFYtpgMFGG 197
Cdd:COG2956   127 EKAIEVLERLLKLGPENAHAYCELAELYLE-------QGDY--DEAIEALEKALKLDPDCARALLLLA--ELY---LEQG 192

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2255991616 198 DKEKALTKFEKAARLAeqgsPDdplmpgwgHAEAHAWVGVAHMEAERYDPARTAFEAALDLNPD 261
Cdd:COG2956   193 DYEEAIAALERALEQD----PD--------YLPALPRLAELYEKLGDPEEALELLRKALELDPS 244
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 197-269 1.84e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 41.10  E-value: 1.84e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2255991616 197 GDKEKALTKFEKAARLAeqgsPDDPlmpgwghaEAHAWVGVAHMEAERYDPARTAFEAALDLNPDYGWVKKVL 269
Cdd:COG5010    68 GDFEESLALLEQALQLD----PNNP--------ELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNL 128
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
197-269 2.36e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 39.38  E-value: 2.36e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2255991616 197 GDKEKALTKFEKAARLAeqgsPDDplmpgwghAEAHAWVGVAHMEAERYDPARtAFEAALDLNPDYGWVKKVL 269
Cdd:COG3063     6 GDLEEAEEYYEKALELD----PDN--------ADALNNLGLLLLEQGRYDEAI-ALEKALKLDPNNAEALLNL 65
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 117-262 3.30e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 41.99  E-value: 3.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255991616 117 IEDAIGHLKRATEINGTMADAWALLsGCYGQMMGMNPMqgmslgpkANEAMKRAKEHGPNNPRVWIIDGTSDFYtpgmfg 196
Cdd:TIGR02917 175 FDEARALIDEVLTADPGNVDALLLK-GDLLLSLGNIEL--------ALAAYRKAIALRPNNIAVLLALATILIE------ 239

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2255991616 197 gdkekaLTKFEKAARLAEQGSPDDPlmpgwGHAEAHAWVGVAHMEAERYDPARTAFEAALDLNPDY 262
Cdd:TIGR02917 240 ------AGEFEEAEKHADALLKKAP-----NSPLAHYLKALVDFQKKNYEDARETLQDALKSAPEY 294
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
162-261 3.35e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 39.00  E-value: 3.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255991616 162 KANEAMKRAKEHGPNNPRVWIIDGTSDFYTpgmfgGDKEKALtKFEKAARLaeqgspdDPlmpgwGHAEAHAWVGVAHME 241
Cdd:COG3063    10 EAEEYYEKALELDPDNADALNNLGLLLLEQ-----GRYDEAI-ALEKALKL-------DP-----NNAEALLNLAELLLE 71

                          90       100
                  ....*....|....*....|
gi 2255991616 242 AERYDPARTAFEAALDLNPD 261
Cdd:COG3063    72 LGDYDEALAYLERALELDPS 91
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 111-222 3.59e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 39.60  E-value: 3.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255991616 111 ARRGRvIEDAIGHLKRATEINGTMADAWALlsgcYGQMMGmnpMQGMSlgPKANEAMKRAKEHGPNNPRVWIIDGTSDFY 190
Cdd:COG4235    28 LRLGR-YDEALAAYEKALRLDPDNADALLD----LAEALL---AAGDT--EEAEELLERALALDPDNPEALYLLGLAAFQ 97

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2255991616 191 TpgmfgGDKEKALTKFEKAARLAEQGSPDDPL 222
Cdd:COG4235    98 Q-----GDYAEAIAAWQKLLALLPADAPARLL 124
TPR_1 pfam00515
Tetratricopeptide repeat;
229-262 4.81e-04

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 36.63  E-value: 4.81e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2255991616 229 AEAHAWVGVAHMEAERYDPARTAFEAALDLNPDY 262
Cdd:pfam00515   1 AKALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
TPR_16 pfam13432
Tetratricopeptide repeat; This family is found predominantly at the C-terminus of ...
 205-262 6.21e-04

Tetratricopeptide repeat; This family is found predominantly at the C-terminus of transglutaminase enzyme core regions.


Pssm-ID: 433202 [Multi-domain]  Cd Length: 68  Bit Score: 37.32  E-value: 6.21e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2255991616 205 KFEKAARLAEQGSPDDPLMPGwgHAEAHAWVGVAHMEAERYDPARTAFEAALDLNPDY 262
Cdd:pfam13432  12 DYDDAAAALEAALARFPESPD--AAAALLLLGLAALRQGRLAEAAAAYRAALRAAPGD 67
TAtT pfam16811
TRAP transporter T-component; TAtT is a family of one component, the T-component, of a sub-set ...
 161-214 1.57e-03

TRAP transporter T-component; TAtT is a family of one component, the T-component, of a sub-set of TRAP-Ts or Tripartite ATP-independent periplasmic transporters. TRAP-Ts are bacterial transport systems implicated in the import of small molecules into the cytoplasm in bacteria. They are all periplasmic lipoproteins. TatT consists of a 13-alpha-helical fold containing cryptic tetratricopeptide repeat motifs (cTPRs) and encompassing a pore, ie is a water-soluble trimer whose protomers are each perforated by a pore. It forms a complex with a P component, and a putative ligand-binding cleft of TatPT aligns with the pore of TatT. Family TatPT is represented by some members of pfam03480.


Pssm-ID: 435596 [Multi-domain]  Cd Length: 263  Bit Score: 39.25  E-value: 1.57e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2255991616 161 PKANEAMKRAKEHGP--NNPRVWIIDGTsdFYT--PGMFGGDKEKALTKFEKAARLAE 214
Cdd:pfam16811 144 PKVEAMMERVLELDEsyYYGAAHLFLGV--YYGsrPPSLGGDPERARAHFERALELSG 199
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
197-261 1.82e-03

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 38.74  E-value: 1.82e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2255991616 197 GDKEKALTKFEKAARLaeqgspdDPlmpgwGHAEAHAWVGVAHMEAERYDPARTAFEAALDLNPD 261
Cdd:COG4785   121 GDYDAALEDFDRALEL-------DP-----DYAYAYLNRGIALYYLGRYELAIADLEKALELDPN 173
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
228-265 4.75e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 37.68  E-value: 4.75e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2255991616 228 HAEAHAWVGVAHMEAERYDPARTAFEAALDLNPDYGWV 265
Cdd:COG0457     7 DAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEA 44
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 197-269 5.88e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 36.32  E-value: 5.88e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2255991616 197 GDKEKALTKFEKAARLaeqgSPDDPlmpgwghaEAHAWVGVAHMEAERYDPARTAFEAALDLNPDYGWVKKVL 269
Cdd:COG4783    18 GDYDEAEALLEKALEL----DPDNP--------EAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNL 78
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
200-262 6.88e-03

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 37.20  E-value: 6.88e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2255991616 200 EKALTKFEKAARLAEQGSPDDPLMPGwgHAEAHAWVGVAHMEAERYDPARTAFEAALDLNPDY 262
Cdd:COG4785    46 LALAAAALAAAALAAERIDRALALPD--LAQLYYERGVAYDSLGDYDLAIADFDQALELDPDL 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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