NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2263059395|ref|WP_252916383|]
View 

trimethylamine methyltransferase family protein [Hoeflea alexandrii]

Protein Classification

trimethylamine methyltransferase family protein( domain architecture ID 10533356)

trimethylamine methyltransferase family protein similar to Desulfitobacterium hafniense glycine betaine methyltransferase that likely methylates a corrinoid protein, likely the adjacently encoded DSY3155, with glycine betaine, to then supply methyl groups to tetrahydrofolate for ultimate conversion to carbon dioxide

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MTTB pfam06253
Trimethylamine methyltransferase (MTTB); This family consists of several trimethylamine ...
 45-527 0e+00

Trimethylamine methyltransferase (MTTB); This family consists of several trimethylamine methyltransferase (MTTB) (EC:2.1.1.-) proteins from numerous Rhizobium and Methanosarcina species.


:

Pssm-ID: 428852  Cd Length: 502  Bit Score: 730.61  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2263059395  45 YRSILNTQEPSLLLSEEGLEAIHEASLAVLEQIGMDFMLKEARDRLAAAGADVVagTERVRLDRGLVLDLVRQAPGPFTL 124
Cdd:pfam06253  21 WPYIVRGIPPYEPLSEEGIAAIEEAAMRILEEIGIEFRDPEALELWRAAGADVD--GERVRFDRGLVRELLATAPRQFTL 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2263059395 125 HARNPERNVNIGGRNLAFAQVASAPYCSDKDNGRRTGTQEDYRNLIRLAQSFDVIHMTGGYPVEPTDLHASVRHLDCLSD 204
Cdd:pfam06253  99 HARNPERDVVIGGNNLVFAPVYGPPFVRDLDRGRRYGTLADFRNFVKLTQMFPWLHHSGGTVVEPVDVPVNKRHLDMLYA 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2263059395 205 LVKLTDKPFHAYSLGKERNLDALEIVRIGRGVSAEQLEAEPSLFTIINASSPLRYDAPMLQGIIEMSSRNQVVVITPFTL 284
Cdd:pfam06253 179 HLTLSDKPFMGSVTGPERAEDSIEMCRILFGLSFAEFRANPVMTTNINVNSPLTFDETMLGGLRVYARAGQAVIVTPFIL 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2263059395 285 AGAMAPVTIAGALVQQNAEALAGIAFTQLVRPGAPVIYGGFTSNVDMKSGAPAFGTPEYMKAVMAGGQLARRYGLPYRTS 364
Cdd:pfam06253 259 AGAMAPVTVAGALAQSLAEALAGIALTQLVRPGAPVIYGTFTSNVDMKSGAPTFGTPEPALATYVAGQLARRYGLPWRSS 338

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2263059395 365 NT-CAANTLDAQSAYESMMSLWALVQGGGNFIMHAAGWMEGGLTASFEKFVMDVDMLQMVAEFLAPLDTSPEALAMDAIA 443
Cdd:pfam06253 339 GGlTASKIPDAQAAYESAMSLWAALLAGANFVLHAAGWLEGGLTASYEKFVMDADMLGMIHRLLAGIDVSDDALAMDAIR 418

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2263059395 444 DVGPGGHYFGTAHTLSRYESAFYSPMLSDWRNFESWSLAGQPTTYDHANRVWKETLAGFEAPALDEAIVEELDAFVARRK 523
Cdd:pfam06253 419 EVGPGGHFLGCAHTQARYETAFYRPELSDWRNFETWEEEGAKDTAERANRRWKKILAEYEAPPLDPAIDEALRDFIARRK 498


                  ....
gi 2263059395 524 LEGG 527
Cdd:pfam06253 499 AEGG 502
 
Name Accession Description Interval E-value
MTTB pfam06253
Trimethylamine methyltransferase (MTTB); This family consists of several trimethylamine ...
 45-527 0e+00

Trimethylamine methyltransferase (MTTB); This family consists of several trimethylamine methyltransferase (MTTB) (EC:2.1.1.-) proteins from numerous Rhizobium and Methanosarcina species.


Pssm-ID: 428852  Cd Length: 502  Bit Score: 730.61  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2263059395  45 YRSILNTQEPSLLLSEEGLEAIHEASLAVLEQIGMDFMLKEARDRLAAAGADVVagTERVRLDRGLVLDLVRQAPGPFTL 124
Cdd:pfam06253  21 WPYIVRGIPPYEPLSEEGIAAIEEAAMRILEEIGIEFRDPEALELWRAAGADVD--GERVRFDRGLVRELLATAPRQFTL 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2263059395 125 HARNPERNVNIGGRNLAFAQVASAPYCSDKDNGRRTGTQEDYRNLIRLAQSFDVIHMTGGYPVEPTDLHASVRHLDCLSD 204
Cdd:pfam06253  99 HARNPERDVVIGGNNLVFAPVYGPPFVRDLDRGRRYGTLADFRNFVKLTQMFPWLHHSGGTVVEPVDVPVNKRHLDMLYA 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2263059395 205 LVKLTDKPFHAYSLGKERNLDALEIVRIGRGVSAEQLEAEPSLFTIINASSPLRYDAPMLQGIIEMSSRNQVVVITPFTL 284
Cdd:pfam06253 179 HLTLSDKPFMGSVTGPERAEDSIEMCRILFGLSFAEFRANPVMTTNINVNSPLTFDETMLGGLRVYARAGQAVIVTPFIL 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2263059395 285 AGAMAPVTIAGALVQQNAEALAGIAFTQLVRPGAPVIYGGFTSNVDMKSGAPAFGTPEYMKAVMAGGQLARRYGLPYRTS 364
Cdd:pfam06253 259 AGAMAPVTVAGALAQSLAEALAGIALTQLVRPGAPVIYGTFTSNVDMKSGAPTFGTPEPALATYVAGQLARRYGLPWRSS 338

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2263059395 365 NT-CAANTLDAQSAYESMMSLWALVQGGGNFIMHAAGWMEGGLTASFEKFVMDVDMLQMVAEFLAPLDTSPEALAMDAIA 443
Cdd:pfam06253 339 GGlTASKIPDAQAAYESAMSLWAALLAGANFVLHAAGWLEGGLTASYEKFVMDADMLGMIHRLLAGIDVSDDALAMDAIR 418

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2263059395 444 DVGPGGHYFGTAHTLSRYESAFYSPMLSDWRNFESWSLAGQPTTYDHANRVWKETLAGFEAPALDEAIVEELDAFVARRK 523
Cdd:pfam06253 419 EVGPGGHFLGCAHTQARYETAFYRPELSDWRNFETWEEEGAKDTAERANRRWKKILAEYEAPPLDPAIDEALRDFIARRK 498


                  ....
gi 2263059395 524 LEGG 527
Cdd:pfam06253 499 AEGG 502
MttB2 COG5598
Trimethylamine:corrinoid methyltransferase [Coenzyme transport and metabolism];
57-522 0e+00

Trimethylamine:corrinoid methyltransferase [Coenzyme transport and metabolism];


Pssm-ID: 444334  Cd Length: 469  Bit Score: 658.00  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2263059395  57 LLSEEGLEAIHEASLAVLEQIGMDFMLKEARDRLAAAGADVVagTERVRLDRGLVLDLVRQAPGPFTLHARNPERNVNIG 136
Cdd:COG5598     5 PLSEEQIERIHEAALRILEEIGVEFEHEEALEIFKKAGARVE--GGRVRIPRALVEEALATAPSSFTLYARNPERDVELG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2263059395 137 GRNLAFAQVASAPYCSDKDNG-RRTGTQEDYRNLIRLAQSFDVIHMTGGYPVEPTDLHASVRHLDCLSDLVKLTDKPFHA 215
Cdd:COG5598    83 GGNVVFGPGGGAPFVLDLETGeRRPATLEDLANFAKLADALPNIDFSGGNPVEPSDVPVEVRHLDMLYAMLKYTDKPIMG 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2263059395 216 YSLGKERNLDALEIVRIGRGvSAEQLEAEPSLFTIINASSPLRYDAPMLQGIIEMSSRNQVVVITPFTLAGAMAPVTIAG 295
Cdd:COG5598   163 SATGRERVEDSIEMARIVAG-GEEELREKPVVITLINPNSPLRFDEEMLEALIAYARAGQPVIITPFGLAGATAPVTLAG 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2263059395 296 ALVQQNAEALAGIAFTQLVRPGAPVIYGGFTSNVDMKSGAPAFGTPEYMKAVMAGGQLARRYGLPYRTSNT-CAANTLDA 374
Cdd:COG5598   242 ALAQQNAEALAGLVLAQLIRPGAPVIYGTFSSSMDMRTGAPAFGTPEAALLSAAAAQLARYYGLPSRSGGGlTDSKLPDA 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2263059395 375 QSAYESMMSLWALVQGGGNFIMHAAGWMEGGLTASFEKFVMDVDMLQMVAEFLAPLDTSPEALAMDAIADVGPGGHYFGT 454
Cdd:COG5598   322 QAGYESAMSLLAAALAGANLILHAAGWLESGLTASYEKFVLDNEIIGMVRRLLRGIEVDEETLALDAIKEVGPGGHFLGH 401

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2263059395 455 AHTLSRYESAFYSPMLSDWRNFESWSLAGQPTTYDHANRVWKETLAGFEAPALDEAIVEELDAFVARR 522
Cdd:COG5598   402 PHTLKHYRTEFYYPKLSDRENYEQWEEAGSKDLLERANEKVKEILAEYEPPPLDPEIDEELDAYIARR 469
 
Name Accession Description Interval E-value
MTTB pfam06253
Trimethylamine methyltransferase (MTTB); This family consists of several trimethylamine ...
 45-527 0e+00

Trimethylamine methyltransferase (MTTB); This family consists of several trimethylamine methyltransferase (MTTB) (EC:2.1.1.-) proteins from numerous Rhizobium and Methanosarcina species.


Pssm-ID: 428852  Cd Length: 502  Bit Score: 730.61  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2263059395  45 YRSILNTQEPSLLLSEEGLEAIHEASLAVLEQIGMDFMLKEARDRLAAAGADVVagTERVRLDRGLVLDLVRQAPGPFTL 124
Cdd:pfam06253  21 WPYIVRGIPPYEPLSEEGIAAIEEAAMRILEEIGIEFRDPEALELWRAAGADVD--GERVRFDRGLVRELLATAPRQFTL 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2263059395 125 HARNPERNVNIGGRNLAFAQVASAPYCSDKDNGRRTGTQEDYRNLIRLAQSFDVIHMTGGYPVEPTDLHASVRHLDCLSD 204
Cdd:pfam06253  99 HARNPERDVVIGGNNLVFAPVYGPPFVRDLDRGRRYGTLADFRNFVKLTQMFPWLHHSGGTVVEPVDVPVNKRHLDMLYA 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2263059395 205 LVKLTDKPFHAYSLGKERNLDALEIVRIGRGVSAEQLEAEPSLFTIINASSPLRYDAPMLQGIIEMSSRNQVVVITPFTL 284
Cdd:pfam06253 179 HLTLSDKPFMGSVTGPERAEDSIEMCRILFGLSFAEFRANPVMTTNINVNSPLTFDETMLGGLRVYARAGQAVIVTPFIL 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2263059395 285 AGAMAPVTIAGALVQQNAEALAGIAFTQLVRPGAPVIYGGFTSNVDMKSGAPAFGTPEYMKAVMAGGQLARRYGLPYRTS 364
Cdd:pfam06253 259 AGAMAPVTVAGALAQSLAEALAGIALTQLVRPGAPVIYGTFTSNVDMKSGAPTFGTPEPALATYVAGQLARRYGLPWRSS 338

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2263059395 365 NT-CAANTLDAQSAYESMMSLWALVQGGGNFIMHAAGWMEGGLTASFEKFVMDVDMLQMVAEFLAPLDTSPEALAMDAIA 443
Cdd:pfam06253 339 GGlTASKIPDAQAAYESAMSLWAALLAGANFVLHAAGWLEGGLTASYEKFVMDADMLGMIHRLLAGIDVSDDALAMDAIR 418

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2263059395 444 DVGPGGHYFGTAHTLSRYESAFYSPMLSDWRNFESWSLAGQPTTYDHANRVWKETLAGFEAPALDEAIVEELDAFVARRK 523
Cdd:pfam06253 419 EVGPGGHFLGCAHTQARYETAFYRPELSDWRNFETWEEEGAKDTAERANRRWKKILAEYEAPPLDPAIDEALRDFIARRK 498


                  ....
gi 2263059395 524 LEGG 527
Cdd:pfam06253 499 AEGG 502
MttB2 COG5598
Trimethylamine:corrinoid methyltransferase [Coenzyme transport and metabolism];
57-522 0e+00

Trimethylamine:corrinoid methyltransferase [Coenzyme transport and metabolism];


Pssm-ID: 444334  Cd Length: 469  Bit Score: 658.00  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2263059395  57 LLSEEGLEAIHEASLAVLEQIGMDFMLKEARDRLAAAGADVVagTERVRLDRGLVLDLVRQAPGPFTLHARNPERNVNIG 136
Cdd:COG5598     5 PLSEEQIERIHEAALRILEEIGVEFEHEEALEIFKKAGARVE--GGRVRIPRALVEEALATAPSSFTLYARNPERDVELG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2263059395 137 GRNLAFAQVASAPYCSDKDNG-RRTGTQEDYRNLIRLAQSFDVIHMTGGYPVEPTDLHASVRHLDCLSDLVKLTDKPFHA 215
Cdd:COG5598    83 GGNVVFGPGGGAPFVLDLETGeRRPATLEDLANFAKLADALPNIDFSGGNPVEPSDVPVEVRHLDMLYAMLKYTDKPIMG 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2263059395 216 YSLGKERNLDALEIVRIGRGvSAEQLEAEPSLFTIINASSPLRYDAPMLQGIIEMSSRNQVVVITPFTLAGAMAPVTIAG 295
Cdd:COG5598   163 SATGRERVEDSIEMARIVAG-GEEELREKPVVITLINPNSPLRFDEEMLEALIAYARAGQPVIITPFGLAGATAPVTLAG 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2263059395 296 ALVQQNAEALAGIAFTQLVRPGAPVIYGGFTSNVDMKSGAPAFGTPEYMKAVMAGGQLARRYGLPYRTSNT-CAANTLDA 374
Cdd:COG5598   242 ALAQQNAEALAGLVLAQLIRPGAPVIYGTFSSSMDMRTGAPAFGTPEAALLSAAAAQLARYYGLPSRSGGGlTDSKLPDA 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2263059395 375 QSAYESMMSLWALVQGGGNFIMHAAGWMEGGLTASFEKFVMDVDMLQMVAEFLAPLDTSPEALAMDAIADVGPGGHYFGT 454
Cdd:COG5598   322 QAGYESAMSLLAAALAGANLILHAAGWLESGLTASYEKFVLDNEIIGMVRRLLRGIEVDEETLALDAIKEVGPGGHFLGH 401

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2263059395 455 AHTLSRYESAFYSPMLSDWRNFESWSLAGQPTTYDHANRVWKETLAGFEAPALDEAIVEELDAFVARR 522
Cdd:COG5598   402 PHTLKHYRTEFYYPKLSDRENYEQWEEAGSKDLLERANEKVKEILAEYEPPPLDPEIDEELDAYIARR 469
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH