NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2267600314|ref|WP_253843202|]
View 

MULTISPECIES: CHRD domain-containing protein [Actinosynnema]

Protein Classification

CHRD domain-containing protein( domain architecture ID 10538485)

CHRD domain-containing protein; CHRD is a domain found in chordin, an inhibitor of bone morphogenetic proteins

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CHRD pfam07452
CHRD domain; CHRD (after SWISS-PROT abbreviation for chordin) is a novel domain identified in ...
 64-172 1.12e-27

CHRD domain; CHRD (after SWISS-PROT abbreviation for chordin) is a novel domain identified in chordin, an inhibitor of bone morphogenetic proteins. This family includes bacterial homologs. It is anticipated to have an immunoglobulin-like beta-barrel structure based on limited similarity to superoxide dismutases but, as yet, no clear functional prediction can be made. Its most conserved feature is a GE[I/L]RCG[V/I/L] motif towards its C-terminal end Most bacterial proteins in this family have only one CHRD domain, whereas it is found repeated in many eukaryotic proteins such as human chordin and Drosophila SOG..


:

Pssm-ID: 462167  Cd Length: 118  Bit Score: 100.25  E-value: 1.12e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2267600314  64 AVLTGAAEVPGPGDPDGYGTARIEVRAT--SVCVKLSTRRIGEATAAHIHAGATGESGPPVVTLDPPVDGYSWDCAR--- 138
Cdd:pfam07452   3 ALLTGAQEVPPPVTTGAGGTAVLTLDDTenTLHYTLTFSGLSVPTAAHIHAGAAGFNGPVVVPLEGGPRKTTLLAVPegl 82

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2267600314 139 --ISLDLAYDLVAHPRDFYVNVHTDAFPDGAIRGQL 172
Cdd:pfam07452  83 atLTAAQLAALLAQQGELYVNVHTEGNPGGEIRGQI 118
 
Name Accession Description Interval E-value
CHRD pfam07452
CHRD domain; CHRD (after SWISS-PROT abbreviation for chordin) is a novel domain identified in ...
 64-172 1.12e-27

CHRD domain; CHRD (after SWISS-PROT abbreviation for chordin) is a novel domain identified in chordin, an inhibitor of bone morphogenetic proteins. This family includes bacterial homologs. It is anticipated to have an immunoglobulin-like beta-barrel structure based on limited similarity to superoxide dismutases but, as yet, no clear functional prediction can be made. Its most conserved feature is a GE[I/L]RCG[V/I/L] motif towards its C-terminal end Most bacterial proteins in this family have only one CHRD domain, whereas it is found repeated in many eukaryotic proteins such as human chordin and Drosophila SOG..


Pssm-ID: 462167  Cd Length: 118  Bit Score: 100.25  E-value: 1.12e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2267600314  64 AVLTGAAEVPGPGDPDGYGTARIEVRAT--SVCVKLSTRRIGEATAAHIHAGATGESGPPVVTLDPPVDGYSWDCAR--- 138
Cdd:pfam07452   3 ALLTGAQEVPPPVTTGAGGTAVLTLDDTenTLHYTLTFSGLSVPTAAHIHAGAAGFNGPVVVPLEGGPRKTTLLAVPegl 82

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2267600314 139 --ISLDLAYDLVAHPRDFYVNVHTDAFPDGAIRGQL 172
Cdd:pfam07452  83 atLTAAQLAALLAQQGELYVNVHTEGNPGGEIRGQI 118
CHRD smart00754
A domain in the BMP inhibitor chordin and in microbial proteins;
64-173 8.52e-19

A domain in the BMP inhibitor chordin and in microbial proteins;


Pssm-ID: 214804  Cd Length: 118  Bit Score: 77.39  E-value: 8.52e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2267600314   64 AVLTGAAEVPgPGDPDGYGTARIEVRA-TSVCVKLSTRRI-GEATAAHIHAGATGESGPPVVTLDPPVDGYSWDCARISL 141
Cdd:smart00754   5 ALLTGSQEVP-PVNTGAVGGAWFTLDDdGSLHYQVTLSGLsGPETAAHIHEGEIGTNGPVVRIPLPNPTSREGPFAGSVK 83

                           90       100       110
                   ....*....|....*....|....*....|....
gi 2267600314  142 DLAYDLVAHPRD--FYVNVHTDAFPDGAIRGQLR 173
Cdd:smart00754  84 TLTDEELRQLLAgnLYVNVHTKANPGGEIRGQVA 117
 
Name Accession Description Interval E-value
CHRD pfam07452
CHRD domain; CHRD (after SWISS-PROT abbreviation for chordin) is a novel domain identified in ...
 64-172 1.12e-27

CHRD domain; CHRD (after SWISS-PROT abbreviation for chordin) is a novel domain identified in chordin, an inhibitor of bone morphogenetic proteins. This family includes bacterial homologs. It is anticipated to have an immunoglobulin-like beta-barrel structure based on limited similarity to superoxide dismutases but, as yet, no clear functional prediction can be made. Its most conserved feature is a GE[I/L]RCG[V/I/L] motif towards its C-terminal end Most bacterial proteins in this family have only one CHRD domain, whereas it is found repeated in many eukaryotic proteins such as human chordin and Drosophila SOG..


Pssm-ID: 462167  Cd Length: 118  Bit Score: 100.25  E-value: 1.12e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2267600314  64 AVLTGAAEVPGPGDPDGYGTARIEVRAT--SVCVKLSTRRIGEATAAHIHAGATGESGPPVVTLDPPVDGYSWDCAR--- 138
Cdd:pfam07452   3 ALLTGAQEVPPPVTTGAGGTAVLTLDDTenTLHYTLTFSGLSVPTAAHIHAGAAGFNGPVVVPLEGGPRKTTLLAVPegl 82

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2267600314 139 --ISLDLAYDLVAHPRDFYVNVHTDAFPDGAIRGQL 172
Cdd:pfam07452  83 atLTAAQLAALLAQQGELYVNVHTEGNPGGEIRGQI 118
CHRD smart00754
A domain in the BMP inhibitor chordin and in microbial proteins;
64-173 8.52e-19

A domain in the BMP inhibitor chordin and in microbial proteins;


Pssm-ID: 214804  Cd Length: 118  Bit Score: 77.39  E-value: 8.52e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2267600314   64 AVLTGAAEVPgPGDPDGYGTARIEVRA-TSVCVKLSTRRI-GEATAAHIHAGATGESGPPVVTLDPPVDGYSWDCARISL 141
Cdd:smart00754   5 ALLTGSQEVP-PVNTGAVGGAWFTLDDdGSLHYQVTLSGLsGPETAAHIHEGEIGTNGPVVRIPLPNPTSREGPFAGSVK 83

                           90       100       110
                   ....*....|....*....|....*....|....
gi 2267600314  142 DLAYDLVAHPRD--FYVNVHTDAFPDGAIRGQLR 173
Cdd:smart00754  84 TLTDEELRQLLAgnLYVNVHTKANPGGEIRGQVA 117
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH