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Conserved domains on  [gi|2267642665|ref|WP_253865960|]
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GntR family transcriptional regulator [Prauserella halophila]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11448455)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain; controls the expression of genes with diverse biological functions

CATH:  1.10.10.10
Gene Ontology:  GO:0003700|GO:0003677
PubMed:  33509775
SCOP:  4000155

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
22-235 2.34e-47

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 155.85  E-value: 2.34e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2267642665  22 NRSLLDRTSTAERVADALRQWIIDGRLLPGTQLSEHSAGKALGVSRNTLREAFRLLVHERLLVHEFHRGVFVRMLDADDV 101
Cdd:COG1802     3 SPSPLRRESLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEEI 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2267642665 102 TDLYRTRRLLEPGAIR-AASDVPPERLAAIEAAITSAEQAAAEERWLDVGTANMRFHQAITALAGSPRADEIMQQLTAEL 180
Cdd:COG1802    83 RELYEVRAALEGLAARlAAERATPADLARLRALLEELEAAAAAGDVAAYLELDREFHRALVEAAGNPRLAELLRRLRARL 162

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2267642665 181 RLAFHATPALRRFHEPYIELNRGIARLLADGDLDAAARTLDDYLTTAQHQLLDAF 235
Cdd:COG1802   163 RRYRRLSLRSPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLLEAL 217
 
Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
22-235 2.34e-47

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 155.85  E-value: 2.34e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2267642665  22 NRSLLDRTSTAERVADALRQWIIDGRLLPGTQLSEHSAGKALGVSRNTLREAFRLLVHERLLVHEFHRGVFVRMLDADDV 101
Cdd:COG1802     3 SPSPLRRESLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEEI 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2267642665 102 TDLYRTRRLLEPGAIR-AASDVPPERLAAIEAAITSAEQAAAEERWLDVGTANMRFHQAITALAGSPRADEIMQQLTAEL 180
Cdd:COG1802    83 RELYEVRAALEGLAARlAAERATPADLARLRALLEELEAAAAAGDVAAYLELDREFHRALVEAAGNPRLAELLRRLRARL 162

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2267642665 181 RLAFHATPALRRFHEPYIELNRGIARLLADGDLDAAARTLDDYLTTAQHQLLDAF 235
Cdd:COG1802   163 RRYRRLSLRSPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLLEAL 217
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 30-94 9.87e-16

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 69.01  E-value: 9.87e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2267642665  30 STAERVADALRQWIIDGRLLPGTQL-SEHSAGKALGVSRNTLREAFRLLVHERLLVHEFHRGVFVR 94
Cdd:cd07377     1 PLYEQIADQLREAILSGELKPGDRLpSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
FCD pfam07729
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ...
 103-220 4.63e-15

FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).


Pssm-ID: 429623 [Multi-domain]  Cd Length: 121  Bit Score: 68.94  E-value: 4.63e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2267642665 103 DLYRTRRLLEPGAIR-AASDVPPERLAAIEAAITSAEQAAAEERWLDVGTANMRFHQAITALAGSPRADEIMQQLTAELR 181
Cdd:pfam07729   1 ELYELRAALEPLAARlAAERATDEDLAELEALLEALEAAADAGDLEAFAEADREFHLALAEAAGNPVLARMLESLWDRLR 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2267642665 182 LAFHATPALRRFHEPYIELNRGIARLLADGDLDAAARTL 220
Cdd:pfam07729  81 RLRRLLLSSPGRLRASLEEHRAILDAIRARDPEAARAAM 119
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
35-93 1.24e-11

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 57.97  E-value: 1.24e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2267642665   35 VADALRQWIIDGRLLPGTQL-SEHSAGKALGVSRNTLREAFRLLVHERLLVHEFHRGVFV 93
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLpSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 32-160 5.31e-05

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 43.22  E-value: 5.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2267642665  32 AERVADALRQWIIDGRLLPGTQL-SEHSAGKALGVSRNTLREAFRLLVHERLLVHEFHRGVFVR---------------- 94
Cdd:PRK10421    4 SDEVADRVRALIEEKNLEAGMKLpAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFIRwrhetwseqnivqplk 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2267642665  95 MLDADDVT---DLYRTRRLLEPG-AIRAASDVPPERLAAIEAAI--TSAEQAAAEERwldvgtANMRFHQAI 160
Cdd:PRK10421   84 TLMADDPDysfDILEARHAIEAStAWHAAMRATPGDKEKIQLCFeaTLSEDPDLASQ------ADVRFHLAI 149
 
Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
22-235 2.34e-47

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 155.85  E-value: 2.34e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2267642665  22 NRSLLDRTSTAERVADALRQWIIDGRLLPGTQLSEHSAGKALGVSRNTLREAFRLLVHERLLVHEFHRGVFVRMLDADDV 101
Cdd:COG1802     3 SPSPLRRESLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEEI 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2267642665 102 TDLYRTRRLLEPGAIR-AASDVPPERLAAIEAAITSAEQAAAEERWLDVGTANMRFHQAITALAGSPRADEIMQQLTAEL 180
Cdd:COG1802    83 RELYEVRAALEGLAARlAAERATPADLARLRALLEELEAAAAAGDVAAYLELDREFHRALVEAAGNPRLAELLRRLRARL 162

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2267642665 181 RLAFHATPALRRFHEPYIELNRGIARLLADGDLDAAARTLDDYLTTAQHQLLDAF 235
Cdd:COG1802   163 RRYRRLSLRSPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLLEAL 217
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
28-236 1.41e-27

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 105.02  E-value: 1.41e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2267642665  28 RTSTAERVADALRQWIIDGRLLPGTQL-SEHSAGKALGVSRNTLREAFRLLVHERLLVHEFHRGVFVR------------ 94
Cdd:COG2186     5 RRSLAEQVAEQLRELILSGELKPGDRLpSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVRepspwalldpla 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2267642665  95 ---MLDADDVTDLYRTRRLLEPGAIR-AASDVPPERLAAIEAAItsAEQAAAEERWLDVGTANMRFHQAITALAGSPRAD 170
Cdd:COG2186    85 lllALDDASLRDLLEARLALEPEAARlAAERATDEDLARLEAAL--AEMEAAADDGEAFAEADLAFHRAIAEASGNPLLA 162

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2267642665 171 EIMQQLTAELRLAFHATPALRRFHEPYIELNRGIARLLADGDLDAAARTLDDYLTTAQHQLLDAFP 236
Cdd:COG2186   163 LLLESLRELLRRSVRLTLRSPEARERSLAEHRAILDAIRAGDPEAARAAMRAHLEAVRERLREALA 228
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 30-94 9.87e-16

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 69.01  E-value: 9.87e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2267642665  30 STAERVADALRQWIIDGRLLPGTQL-SEHSAGKALGVSRNTLREAFRLLVHERLLVHEFHRGVFVR 94
Cdd:cd07377     1 PLYEQIADQLREAILSGELKPGDRLpSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
FCD pfam07729
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ...
 103-220 4.63e-15

FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).


Pssm-ID: 429623 [Multi-domain]  Cd Length: 121  Bit Score: 68.94  E-value: 4.63e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2267642665 103 DLYRTRRLLEPGAIR-AASDVPPERLAAIEAAITSAEQAAAEERWLDVGTANMRFHQAITALAGSPRADEIMQQLTAELR 181
Cdd:pfam07729   1 ELYELRAALEPLAARlAAERATDEDLAELEALLEALEAAADAGDLEAFAEADREFHLALAEAAGNPVLARMLESLWDRLR 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2267642665 182 LAFHATPALRRFHEPYIELNRGIARLLADGDLDAAARTL 220
Cdd:pfam07729  81 RLRRLLLSSPGRLRASLEEHRAILDAIRARDPEAARAAM 119
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 31-93 3.62e-12

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 59.55  E-value: 3.62e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2267642665  31 TAERVADALRQWIIDGRLLPGTQL-SEHSAGKALGVSRNTLREAFRLLVHERLLVHEFHRGVFV 93
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLpSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
35-93 1.24e-11

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 57.97  E-value: 1.24e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2267642665   35 VADALRQWIIDGRLLPGTQL-SEHSAGKALGVSRNTLREAFRLLVHERLLVHEFHRGVFV 93
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLpSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
 103-225 1.97e-11

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 59.30  E-value: 1.97e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2267642665  103 DLYRTRRLLEPGAIR-AASDVPPERLAAIEAAITSAEQAAAEERWLD-VGTANMRFHQAITALAGSPRADEIMQQLTAEL 180
Cdd:smart00895   1 ELYEVRRALEPLAARlAAERATDEDLAALEALLDAMEAAAAAGDDLEeFAELDREFHRALAEAAGNPVLLELLESLRARL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 2267642665  181 RLAFHATPALRRFHepyIELNRGIARLLADGDLDAAARTLDDYLT 225
Cdd:smart00895  81 RRLRRLSLEAARRA---LDEHRAILDAIRARDAEAARAAMREHLE 122
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
33-94 3.23e-10

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 58.33  E-value: 3.23e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2267642665  33 ERVADALRQWIIDGRLLPGTQL-SEHSAGKALGVSRNTLREAFRLLVHERLLVHEFHRGVFVR 94
Cdd:COG2188     8 LQIADALRERIESGELPPGDRLpSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVA 70
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 26-94 2.26e-07

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 50.60  E-value: 2.26e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2267642665  26 LDRTSTA---ERVADALRQWIIDGRLLPGTQL-SEHSAGKALGVSRNTLREAFRLLVHERLLVHEFHRGVFVR 94
Cdd:COG1167     5 LDRDSSGplyLQLADALREAILSGRLPPGDRLpSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVA 77
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 32-160 5.31e-05

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 43.22  E-value: 5.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2267642665  32 AERVADALRQWIIDGRLLPGTQL-SEHSAGKALGVSRNTLREAFRLLVHERLLVHEFHRGVFVR---------------- 94
Cdd:PRK10421    4 SDEVADRVRALIEEKNLEAGMKLpAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFIRwrhetwseqnivqplk 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2267642665  95 MLDADDVT---DLYRTRRLLEPG-AIRAASDVPPERLAAIEAAI--TSAEQAAAEERwldvgtANMRFHQAI 160
Cdd:PRK10421   84 TLMADDPDysfDILEARHAIEAStAWHAAMRATPGDKEKIQLCFeaTLSEDPDLASQ------ADVRFHLAI 149
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 33-227 7.63e-05

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 42.70  E-value: 7.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2267642665  33 ERVADALRQWIIDGRLLPGTQL-SEHSAGKALGVSRNTLREAFRLLVH---------ERLLVHEFHRGVFVRMLDA---- 98
Cdd:PRK03837   16 EEVEERLEQMIRSGEFGPGDQLpSERELMAFFGVGRPAVREALQALKRkglvqishgERARVSRPSADTIIGQLSGmakd 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2267642665  99 ------DDVTDLYRTRRLLEPGAIR-AASDVPPERLAAIEAAITSAEQAAAEERwlDVGTANMRFHQAITALAGSPRADE 171
Cdd:PRK03837   96 flsqspDGLAHLKQARLFFESSLARyAAEHATDEQIALLRKALERNSQSLGDNA--AFIRSDMEFHRVIAEIPGNPIFMA 173

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2267642665 172 IMQQLTAELRLAFHATPALRRFHEPYIELNRGIARLLADGDLDAAARTLDDYLTTA 227
Cdd:PRK03837  174 IHEALLDWLIEARPEVVILHGHENVTLQEHIAIVDAIRAHDPDEADRALQSHLNRV 229
PRK09764 PRK09764
GntR family transcriptional regulator;
34-94 1.42e-04

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 41.74  E-value: 1.42e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2267642665  34 RVADALRQWIIDGRLLPGTQL-SEHSAGKALGVSRNTLREAFRLLVHERLLVHEFHRGVFVR 94
Cdd:PRK09764    9 QIADRIREQIARGELKPGDALpTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVK 70
PRK11414 PRK11414
GntR family transcriptional regulator;
30-224 4.53e-04

GntR family transcriptional regulator;


Pssm-ID: 183126 [Multi-domain]  Cd Length: 221  Bit Score: 40.24  E-value: 4.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2267642665  30 STAERVADALRQWIIDGRLLPGTQLSEHSAGKALGVSRNTLREAFRLLVHERLLVHEFHRGVFVRMLDADDVTDLYRTRR 109
Cdd:PRK11414   11 SLTLQVENDLKHQLSIGALKPGARLITKNLAEQLGMSITPVREALLRLVSVNALSVAPAQAFTVPEVSKRQLDEINRIRY 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2267642665 110 LLEPGAIRAAS-DVPPERLAAIEAAITSAEQAAAEERWLDVGTANMRFHQAITALAGSPRADEIMQQLTAELrlafhaTP 188
Cdd:PRK11414   91 ELELMAVALAVeNLTPQDLAELQELLEKLQQAQEKGDMEQIINANRLFRLAIYHRSNMPILCEMIEQLWVRM------GP 164

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 2267642665 189 ALRRFHEPY--------IELNRGIARLLADGDLDAAARTLDDYL 224
Cdd:PRK11414  165 SLHYLYEAInpaelrehIENYRLLLAALKAKDKEGCRHCLAEIM 208
PRK11534 PRK11534
DNA-binding transcriptional regulator CsiR; Provisional
 39-167 7.54e-04

DNA-binding transcriptional regulator CsiR; Provisional


Pssm-ID: 183181 [Multi-domain]  Cd Length: 224  Bit Score: 39.49  E-value: 7.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2267642665  39 LRQWIIDGRLLPGTQL--SEHSAGKALGVSrnTLREAFRLLVHERLLVHEFHRGVFVRMLDADDVTDLYRTRRLLEPGAI 116
Cdd:PRK11534   16 LKNDIIRGNFQPDEKLrmSLLTSRYALGVG--PLREALSQLVAERLVTVVNQKGYRVASMSEQELLDIFDARANMEAMLV 93

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2267642665 117 RAA----SDVPPERLAAIEAAITSAEQAAAEERWLDV-GTANMRFHQAITALAGSP 167
Cdd:PRK11534   94 SLAiargGDEWEADVLAKAHLLSKLEACDASEKMLDEwDLRHQAFHTAIVAGCGSH 149
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
39-164 1.08e-03

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 39.23  E-value: 1.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2267642665  39 LRQWIIDGRLLPGTQL-SEHSAGKALGVSRNTLREAFRLLVHERLLVHEFHRGVFV-------------RMLDADDVT-- 102
Cdd:PRK09464   19 LEFLILEGTLRPGEKLpPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVqsslwqsfsdplvELLSDHPESqf 98

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2267642665 103 DLYRTRRLLEP-GAIRAASDVPPERLAAIEAAITSAEQAAAEERWLDVGTANMRFHQAITALA 164
Cdd:PRK09464   99 DLLETRHALEGiAAYYAALRGTDEDFERIRECHHAIELAQQSGDLDAEANAVMQYQIAVTEAA 161
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 27-120 1.24e-03

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 38.98  E-value: 1.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2267642665  27 DRTSTAERVADALRQWIIDGRLLPGTQL-SEHSAGKALGVSRNTLREAFRLLVHERLLVHEFHRGVFVRMLDADDVT--- 102
Cdd:PRK09990    4 ERRPIADVVAERIERLIVDGVLKVGQALpSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGSFVARLNRVQDAspl 83

                          90       100       110
                  ....*....|....*....|....*....|
gi 2267642665 103 ------------DLYRTRRLLEPGAIRAAS 120
Cdd:PRK09990   84 mhlfssqprtlyDLLEVRALLEGESARLAA 113
PRK15481 PRK15481
transcriptional regulatory protein PtsJ; Provisional
 31-98 5.42e-03

transcriptional regulatory protein PtsJ; Provisional


Pssm-ID: 185378 [Multi-domain]  Cd Length: 431  Bit Score: 37.33  E-value: 5.42e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2267642665  31 TAERVADALRQWIIDGRLLPGTQL-SEHSAGKALGVSRNTLREAFRLLVHERLLVHEFHRGVFVRMLDA 98
Cdd:PRK15481    6 TANEIFDSIRQLIQAGRLRPGDSLpPVRELASELGVNRNTVAAAYKRLVTAGLAQSQGRNGTVIRGSPS 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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