Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2267642705   3 YVIAEPCVDVLDKSCIDECPVDCIYEGDRML-YIHPDECVDCGACEPVCPVEAIYYEDDV 61
Cdd:cd04410    44 AFLPVSCMHCEDPPCVKACPTGAIYKDEDGIvLIDEDKCIGCGSCVEACPYGAIVFDPEP 103

electron transport complex subunit RsxB;

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2267642705  17 CIDECPVDCIYEG-DRMLYIHPDECVDCGACEPVCPVEAI 55
Cdd:PRK06991   93 CMQACPVDAIVGApKQMHTVLADLCTGCDLCVPPCPVDCI 132

EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight conserved Cys residues in two CxxCxxCxxxCP motifs, each of which binds a 4Fe-4S cluster. The N-terminal region resembles flavodoxin domains, with some members of the family recognized by Pfam models PF12724 (Flavodoxin_5) or PF00258 (Flavodoxin_1).

                          10        20
                  ....*....|....*....|....*.
gi 2267642705  38 DECVDCGACEPVCPVEAIYYEDDVPE 63
Cdd:NF038196  185 DKCIGCGICAKVCPVNNIEMEDGKPV 210

NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and metabolism];

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2267642705   1 MTYVIAEPCVDvlDKSCIDECPVDCIY---EGDRMLYIHPDECVDCGACEPVCPVEAIYYEDDVPEEW 65
Cdd:COG1146     2 MPVIDTDKCIG--CGACVEVCPVDVLEldeEGKKALVINPEECIGCGACELVCPVGAITVEDDEPEEQ 67

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2267642705  17 CIDECPVDCIYEGDRMLYIHPDECVDCGACEPVCPVEAIYYEDDVPE 63
Cdd:COG4624    99 CVRACPVKAIKVDDGKAEIDEEKCISCGQCVAVCPFGAITEKSDIEK 145

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2267642705  17 CIDECPVDCIYEGDRMLYIHPDECVDCGACEPVCPVEAIYYE 58
Cdd:COG2221    23 CVAVCPTGAISLDDGKLVIDEEKCIGCGACIRVCPTGAIKGE 64

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2267642705  16 SCIDECPVDCIYEGDRMLY-IHPDECVDCGACEPVCPVEAI 55
Cdd:COG2878   144 DCIKACPFDAIVGAAKGMHtVDEDKCTGCGLCVEACPVDCI 184

Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit [Energy production and conversion]; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit is part of the Pathway/BioSystem: Pyruvate oxidation

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2267642705  15 KSCIDECPVDCIYEGD-RMLYIHPDECVDCGACEPVCPVEAI 55
Cdd:COG1144    36 GLCWIVCPDGAIRVDDgKYYGIDYDYCKGCGICAEVCPVKAI 77

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2267642705   9 CVDVLDKSCIDECPVDCIYEGDRMLYIHPDECVDCGACEPVCPVEAIYYEDDVPE 63
Cdd:COG4624    62 CRCCVAISCIQVRGIIIIDKRGPSIIRDKEKCKNCYPCVRACPVKAIKVDDGKAE 116

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2267642705  17 CIDECPVDCI-YEGDRMLYIHPDECVDCGACEPVCPVEAIYYE 58
Cdd:cd10549    86 CVKVCPVDAItLEDELEIVIDKEKCIGCGICAEVCPVNAIKLV 128

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2267642705  17 CIDECPVDCIY-------EGDRMLYIHPDECVDCGACEPVCPVEA 54
Cdd:pfam12838   7 CVAACPVGAITldevgekKGTKTVVIDPERCVGCGACVAVCPTGA 51

electron transport complex subunit RsxB;

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2267642705  17 CIDECPVDCIYEG-DRMLYIHPDECVDCGACEPVCPVEAI 55
Cdd:PRK06991   93 CMQACPVDAIVGApKQMHTVLADLCTGCDLCVPPCPVDCI 132

electron transport complex, RnfABCDGE type, B subunit; The six subunit complex RnfABCDGE in Rhodobacter capsulatus encodes an apparent NADH oxidoreductase responsible for electron transport to nitrogenase, necessary for nitrogen fixation. A closely related complex in E. coli, RsxABCDGE (Reducer of SoxR), reduces the 2Fe-2S-containing superoxide sensor SoxR, active as a transcription factor when oxidized. This family of putative NADH oxidoreductase complexes exists in many of the same species as the related NQR, a Na(+)-translocating NADH-quinone reductase, but is distinct. This model describes the B subunit. [Energy metabolism, Electron transport]

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2267642705  17 CIDECPVDCIYEGDR-MLYIHPDECVDCGACEPVCPVEAI 55
Cdd:TIGR01944 121 CIQACPVDAIVGAAKaMHTVIADECTGCDLCVEPCPTDCI 160

hypothetical protein; Provisional

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2267642705  17 CIDECPVDCIY--EGDRMLYIHPDECVDCGACEPVCPVEAIY 56
Cdd:PRK13795  589 CVGACPTGAIRieEGKRKISVDEEKCIHCGKCTEVCPVVKYK 630

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2267642705  17 CIDECPVDCI----YEGDRMLYIHPDECVDCGACEPVCPVE---AIY 56
Cdd:cd16373   105 CVEACPTEAIaivlEDDVLRPVVDEDKCVGCGLCEYVCPVEppkAIV 151

uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes the beta-subunit of formate dehydrogenases that are as yet uncharacterized. Members of the DMSO reductase family include formate dehydrogenase N and O (FDH-N, FDH-O) and tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N, a major component of nitrate respiration of Escherichia coli, is involved in the major anaerobic respiratory pathway in the presence of nitrate, catalyzing the oxidation of formate to carbon dioxide at the expense of nitrate reduction to nitrite. It forms a heterotrimer; the alpha-subunit (FDH-G) is the catalytic site of formate oxidation and membrane-associated, incorporating a selenocysteine (SeCys) residue and a [4Fe/4S] cluster in addition to two bis-MGD cofactors, the beta subunit (FDH-H) contains four [4Fe/4S] clusters which transfer the electrons from the alpha subunit to the gamma-subunit (FDH-I), a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. W-FDH contains a tungsten instead of molybdenum at the catalytic center. This enzyme seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It is a heterodimer of a large and a small subunit; the large subunit harbors the W site and one [4Fe-4S] center and the small subunit, containing three [4Fe-4S] clusters, functions to transfer electrons.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2267642705   9 CVDVLDKSCIDECPVDCIYEGDR-MLYIHPDECVDCGACEPVCPVEAIYYEDDVP 62
Cdd:cd10562    70 CMHCTDAACVKVCPTGALYKTENgAVVVDEDKCIGCGYCVAACPFDVPRYDETTN 124

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2267642705  17 CIDECPVDCIY---------EGDRMLYIHPDECVDCGACEPVCPVEAIYYEDD 60
Cdd:cd10549    48 CVEVCPTGAIEltpegkeyvPKEKEAEIDEEKCIGCGLCVKVCPVDAITLEDE 100

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2267642705  15 KSCIDECPVDCI-YEGDRMLYIHPDECVDCGACEPVCPVEAIY---YEDD 60
Cdd:COG1148   502 GRCVEVCPYGAIsIDEKGVAEVNPALCKGCGTCAAACPSGAISlkgFTDD 551

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2267642705  17 CIDECPVDCIYEGDRMLY-IHPDECVDCGACEPVCPVEAIYYEDDVPE 63
Cdd:cd16372    55 CIDVCPTGAITRDANGVVmINKKLCVGCLMCVGFCPEGAMFKHEDYPE 102

Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and conversion];

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2267642705   8 PCVDVldkscideCPVDCIY-EGDRMLYIHPDECVDCGACEPVCPVEAIYYEDD 60
Cdd:COG0437    67 PCVKV--------CPTGATYkREDGIVLVDYDKCIGCRYCVAACPYGAPRFNPE 112

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2267642705  14 DKSCIDECPVDCIY--EGDRMLYIHPDECVDCGACEPVCPVEAI 55
Cdd:cd10550    54 DAPCVEACPVGAISrdEETGAVVVDEDKCIGCGMCVEACPFGAI 97

4Fe-4S dicluster domain;

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2267642705  15 KSCIDECPVDCIYEGDRM----LYIHPDECVDCGACEPVCPVEAI 55
Cdd:pfam13187   6 GACVAACPAGAIVPDLVGqtirGDIAGLACIGCGACVDACPRGAI 50

Ferredoxin-like protein FixX [Energy production and conversion];

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2267642705   9 CVDV-LDKSCIDECPVDCiYE--GDRMLYIHPDECVDCGACEPVCPVEAI 55
Cdd:COG2440    23 CIARcLAKPCTRYCPAGV-YEivGDGRLQINYENCLECGTCRIKCPTQNI 71

NADH-quinone oxidoreductase subunit NuoI;

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2267642705  21 CPVDCIY-------EGDRMLYIHP---DECVDCGACEPVCPVEAIY 56
Cdd:PRK05888   70 CPADAITieaaereDGRRRTTRYDinfGRCIFCGFCEEACPTDAIV 115

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];

                          10        20        30
                  ....*....|....*....|....*....|
gi 2267642705  31 RMLYIHPDECVDCGACEPVCPVEAIYYEDD 60
Cdd:COG1149     4 KIPVIDEEKCIGCGLCVEVCPEGAIKLDDG 33

EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight conserved Cys residues in two CxxCxxCxxxCP motifs, each of which binds a 4Fe-4S cluster. The N-terminal region resembles flavodoxin domains, with some members of the family recognized by Pfam models PF12724 (Flavodoxin_5) or PF00258 (Flavodoxin_1).

                          10        20
                  ....*....|....*....|....*.
gi 2267642705  38 DECVDCGACEPVCPVEAIYYEDDVPE 63
Cdd:NF038196  185 DKCIGCGICAKVCPVNNIEMEDGKPV 210