|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
1-403 |
7.06e-68 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 219.36 E-value: 7.06e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 1 MFFINYLDRTAIGFAAPNgMEADLALSAAQFGFASGVFFIGYILLEVPSNLALHRFGARRWLARIMVSWGIVALLFTWVQ 80
Cdd:cd17319 11 AYVINYLDRVNISVAAPT-IMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFAT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 81 NFEQLVALRFLLGVAEAGFFPGAILFLSLWVPAKHRSKILALFYLAQPLTTVIGAPLAGFLIEqdgilgLEGWRFMFLGV 160
Cdd:cd17319 90 SLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLL------LFGWRWAFIIE 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 161 SLPAIVVGVI---------------------AWFYLkdkpsdakwltreeqvwlttalkreedvktqgvtthpkmstaft 219
Cdd:cd17319 164 GLLGLLLAVLwwfylrqvwglalgyfginyaLYGLL-------------------------------------------- 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 220 sgrvwmlsfvyfgfiyglyalaFFLPTIIegfQEQYGttFGIFEKGLITAIPYVPAAIALYLWSR--DATRRGVRTWHIV 297
Cdd:cd17319 200 ----------------------TWLPTYL---KQARG--FSLKQVGLLAAIPFLAGAIGMILGGRlsDRLLRGARRLVII 252
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 298 IPAIAGGLSIPLALFAGSPAATIAVITVTAMAIFSALPNFWTFPTRFLTGAAAAAGIALINTVGNLAGFSAPYITGALRD 377
Cdd:cd17319 253 IGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVD 332
|
410 420
....*....|....*....|....*.
gi 2269430540 378 ATGGYEVPMFIVGFFLLLSAVLMALL 403
Cdd:cd17319 333 ATGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
2-404 |
7.06e-67 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 218.36 E-value: 7.06e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 2 FFINYLDRTAIGFAAPNGMEaDLALSAAQFGFASGVFFIGYILLEVPSNLALHRFGARRWLARIMVSWGIVALLFTWVQN 81
Cdd:TIGR00893 3 TVINYLDRANLSFAAPMLQE-DLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAGA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 82 FEQLVALRFLLGVAEAGFFPGAILFLSLWVPAKHRSKILALFYLAQPLTTVIGAPLAGFLIEQdgilglEGWRFMFLGVS 161
Cdd:TIGR00893 82 YVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIH------FSWQWAFIIEG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 162 LPAIVVGVIAWFYLKDKPSDAKWLTREEQVWLTTALKREEDVKTQGVTTHPKMSTAFTSGRVWMLSFVYFGFIYGLYALA 241
Cdd:TIGR00893 156 VLGIIWGVLWLKFIPDPPQKAKWLTEEEKYIVVGGLLAEQQGKGPSTPKKYQIKELLKDRRVWGLALGQFLVNIGLGFFL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 242 FFLPTIIEGFQeqygtTFGIFEKGLITAIPYVPAAIALYLWSRDATRRGVRTWHIVI----PAIAGGLSIPLALFAGSPA 317
Cdd:TIGR00893 236 TWFPTYLVQER-----GLSILEAGFMASLPGIVGFIGMILGGRLSDLLLRRGKSLVFarktAIIAGLVLSLLMFATNYVN 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 318 ATIAVITVTAMAIFSAL--PNFWTFPTRFLTGAAAAAGIALINTVGNLAGFSAPYITGALRDATGGYEVPMFIVGFFLLL 395
Cdd:TIGR00893 311 IPYAALALVALGFFGLGagAIGWALISDNAPGNIAGLTGGLINSLGNLGGIVGPIVIGAIAATTGSFAGALMVVAALALI 390
|
....*....
gi 2269430540 396 SAVLMALLA 404
Cdd:TIGR00893 391 GALSYLLLV 399
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
1-408 |
1.56e-51 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 176.98 E-value: 1.56e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 1 MFFINYLDRTAIGFAAPNgMEADLALSAAQFGFASGVFFIGYILLEVPSNLALHRFGARRWLARIMVSWGIVALLFTWVQ 80
Cdd:COG2271 18 AYFLNYLDRSNLSVAAPP-LQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFAT 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 81 NFEQLVALRFLLGVAEAGFFPGAILFLSLWVPAKHRSKILALFYLAQPLTTVIGAPLAGFLIEQDgilgleGWRFMFLGV 160
Cdd:COG2271 97 SFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF------GWRAAFLIL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 161 SLPAIVVGVIawfylkdkpsdakwltreeqvwlttalkreedvktqgvtthpkmstaftsgRVWMLSFVYFGFIYGLYAL 240
Cdd:COG2271 171 GLPGLLLALL---------------------------------------------------RFWLLALAYFLVYFALYGF 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 241 AFFLPTIiegFQEQYGttFGIFEKGLITAIPYVPAAIALYLWSRDATRRGVRT-WHIVIPAIAGGLSIPLALFAGSPAAT 319
Cdd:COG2271 200 LTWLPTY---LVEVRG--LSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRkLVLAIGLLLAALALLLLALLPSPALA 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 320 IAVITVTAMAIFSALPNFWTFPTRFLTGAAAAAGIALINTVGNLAGFSAPYITGALRDATgGYEVPMFIVGFFLLLSAVL 399
Cdd:COG2271 275 IALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDAT-GYQAAFLLLAALALLAALL 353
|
....*....
gi 2269430540 400 MALLARRYK 408
Cdd:COG2271 354 ALLLLRETR 362
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
1-411 |
3.01e-51 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 177.00 E-value: 3.01e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 1 MFFINYLDRTAIGFAAPNgMEADLALSAAQFGFASGVFFIGYILLEVPSNLALHRFGARRWLARIMVSWGIVALLFTWVQ 80
Cdd:COG2223 13 AFFLAFGVWYLWSVLAPP-LAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 81 NFEQLVALRFLLGVAEAGFFPGAILFLSLWVPAKHRSKILALFYLAQPLTTVIGAPLAGFLIEQdgilglEGWRFMFLGV 160
Cdd:COG2223 92 SYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAA------FGWRNAFLIL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 161 SLPAIVVGVIAWFYLKDKPSDAKWLTReeqvwlttalkreedvktqgvTTHPKMSTAFTSGRVWMLSFVYFGFIYGLYAL 240
Cdd:COG2223 166 GILLLVVAVLAWLFLRDPPAGAAAAAK---------------------ASLRDQLEALRDPRFWLLSLLYFGTFGSFIGF 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 241 AFFLPTIiegFQEQYGttFGIFEKGLITAIPYVPAAIALYLWSRDATRRGVRTWHIVIPAIAGGLSIPLALFAGS-PAAT 319
Cdd:COG2223 225 SSWLPPY---LVDQFG--LSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSlWLFL 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 320 IAVITVTAMAIFSALPNFWTFPTRFLTgAAAAAGIALINTVGNLAGFSAPYITGALRDATGGYEVPMFIVGFFLLLSAVL 399
Cdd:COG2223 300 VLFLLLGLALGGGNGAVFALVPDIFPT-KNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVL 378
|
410
....*....|..
gi 2269430540 400 MALLARRYKDAP 411
Cdd:COG2223 379 TLLLYRRPRRAA 390
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
1-307 |
5.41e-51 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 176.67 E-value: 5.41e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 1 MFFINYLDRTAIGFAAPNGMEADLALSAAQFGFASGVFFIGYILLEVPSNLALHRFGARRWLARIMVSWGIVALLFTWVQ 80
Cdd:cd17327 13 LYFLQYLDKSNISNAAVMGMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVK 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 81 NFEQLVALRFLLGVAEAGFFPGAILFLSLWVPAKHRSKILALFYLAQPLTTVIGAPLAGFLIEQDGILGLEGWRFMFLGV 160
Cdd:cd17327 93 NFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKILGVGGLAGWRWLFIIE 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 161 SLPAIVVGVIAWFYLKDKPSDAKWLTREEQVWlttALKREEDVKTQGVTTHPKMS---TAFTSGRVWMLSFVYFGFIYGL 237
Cdd:cd17327 173 GLITIIIGLVIFFWLPDNPSKAWFLTEEEKEL---AVERLRANQTGKGDQKFKWKqikEAFKDPRTWLLFLFFFCSQITN 249
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2269430540 238 YALAFFLPTIIEGFQeqygttFGIFEKGLITAIPYVPAAIALYLWSRDATRRGVRTWHIV---IPAIAGGLSI 307
Cdd:cd17327 250 NGISNFLPLILKSLG------FYSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGLFAIfacVLALVGSIIL 316
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
1-369 |
6.31e-26 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 107.50 E-value: 6.31e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 1 MFFINYLDRTAIGFAAPNGMEADLALSAAQFGFASGVFFIGYILLEVPSNLALHRFGARRWLARIMVSWGIVALLFTWVQ 80
Cdd:pfam07690 4 AAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 81 NFEQLVALRFLLGVAEAGFFPGAILFLSLWVPAKHRSKILALFYLAQPLTTVIGAPLAGFLIEqdgilgLEGWRFMFLGV 160
Cdd:pfam07690 84 SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAS------LFGWRAAFLIL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 161 SLPAIVVGVIAWFYLKDKPSDAKWLTREEQVWLTTALKreedvktqgvtthpkmstAFTSGRVWMLSFVYFGFIYGLYAL 240
Cdd:pfam07690 158 AILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWK------------------ALLRDPVLWLLLALLLFGFAFFGL 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 241 AFFLPTIIEGFQeqygttFGIFEKGLITAIPYVPAAIALYLWSR--DATRRGVRTWHIVIPAIAGGLSIPLALFAGSPAA 318
Cdd:pfam07690 220 LTYLPLYQEVLG------LSALLAGLLLGLGGLLGAIGRLLLGRlsDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLW 293
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 2269430540 319 TIAVITVTAMAIFSALPNFWTFPTRFLTGAAAAAGIALINTVGNLAGFSAP 369
Cdd:pfam07690 294 LLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
1-365 |
1.11e-23 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 101.20 E-value: 1.11e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 1 MFFINYLDRTAIGFAAPNgMEADLALSAAQFGFASGVFFIGYILLEVPSNLALHRFGARRWLARIMVSWGIVALLFTWVQ 80
Cdd:COG2814 18 GAFLSGLGIGIVLPALPL-IAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAP 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 81 NFEQLVALRFLLGVAEAGFFPGAILFLSLWVPAKHRSKILALFYLAQPLTTVIGAPLAGFLIEqdgilgLEGWRFMFLGV 160
Cdd:COG2814 97 SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD------LFGWRWVFLVN 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 161 SLPAIVVGVIAWFYLKdkpsdakwltreeqvwlttalkreEDVKTQGVTTHPKMSTAFTSGRVWMLSFVYFGFIYGLYAL 240
Cdd:COG2814 171 AVLALLALLLLLRLLP------------------------ESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFAL 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 241 AFFLPTIiegFQEQYGttFGIFEKGLITAIPYVPAAIALYLWSRDATRRGvRTWHIVIPAIAGGLSIPLALFAGSPAATI 320
Cdd:COG2814 227 FTYLPLY---LQEVLG--LSASAAGLLLALFGLGGVLGALLAGRLADRFG-RRRLLLIGLLLLALGLLLLALAGSLWLLL 300
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 2269430540 321 AVITVTAMAIFSALPNFWTFPTRFLTGAAAAAGIALINTVGNLAG 365
Cdd:COG2814 301 LALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
1-399 |
3.49e-23 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 100.19 E-value: 3.49e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 1 MFFINYLDRTAIGFAAPNgMEADLALSAAQFGFASGVFFIGYILLEVPSNLALHRFGARRWLARIMVSWGIVALLFTWVQ 80
Cdd:cd06174 4 GFFLTGLARGLISPLLPA-LLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 81 NFEQLVALRFLLGVAEAGFFPGAILFLSLWVPAKHRSKILALFYLAQPLTTVIGAPLAGFLIEQDGIlgleGWRFMFLGV 160
Cdd:cd06174 83 SFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGF----GWRAVFLIA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 161 SLPAIVVGVIAWFYLKDKPSDAkwltreeqvwlttalkREEDVKTQGVTTHPKMSTAFTSGRVWMLSFVYFGFIYGLYAL 240
Cdd:cd06174 159 AALALLAAILLLLVVPDPPESA----------------RAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSF 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 241 AFFLPTIIEGFQEQYGTTFGIfekglITAIPYVPAAIALYLWSRDATRRGVRTWHIVIPAIAGGLSIPLALFAGSPAATI 320
Cdd:cd06174 223 STLLPLFLLDLGGLSVAVAGL-----LLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLL 297
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2269430540 321 AVITVTAMAIFSALPNFWTFPTRFLTGAAAAAGIALINTVGNLAGFSAPYITGALRDATGGYEVPMFIVGFFLLLSAVL 399
Cdd:cd06174 298 LLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAIL 376
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
22-404 |
8.17e-22 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 96.11 E-value: 8.17e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 22 ADLALSAAQFGFASGVFFIGYILLEVPSNLALHRFGARRWLARIMVSWGIVALLFTWVQNFEQLVALRFLLGVAEAGFFP 101
Cdd:cd17325 24 ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 102 GAILFLSLWVPAKHRSKILALFYLAQPLTTVIGAPLAGFLIEQdgilglEGWRFMFLGVSLPAIVVGVIAWFYLKDKPsd 181
Cdd:cd17325 104 AAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADA------LGYRAPFLVCAALALLALVLALLLLPEPR-- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 182 akwltreeqvwlttalKREEDVKTQGVTTHPKMSTAFTSGRVWMLSFVYFGFIYGLYALAFFLPTIIEGFQEqygttFGI 261
Cdd:cd17325 176 ----------------PPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGG-----LSP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 262 FEKGLITAIPYVPAAIALYLWSRDATRRGvRTWHIVIPAIAGGLSIPLALFAGSPAATIAVITVTAMAIFSALPNFWTFP 341
Cdd:cd17325 235 AQIGLLFGAQGLASALSQPPAGKLSDRIG-RKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALL 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2269430540 342 TRFLTGAAAAAGIALINTVGNLAGFSAPYITGALRDaTGGYEVPMFIVGFFLLLSAVLMALLA 404
Cdd:cd17325 314 ADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYD-AFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
20-411 |
8.65e-16 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 78.38 E-value: 8.65e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 20 MEADLALSAAQFGFASGVFFIGYILLEVPSNLALHRFGARRWLARIMVSWGIVALLFTWVQNFEQLVALRFLLGVAEAGF 99
Cdd:COG2807 44 IRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVG 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 100 FPGAILFLSLWVPaKHRSKILALFYLAQPLTTVIGAPLAGFLIEqdgilgLEGWRFMFLGVSLPAIVVGVIAWFYLKDKP 179
Cdd:COG2807 124 NVLLPGLIKRWFP-DRVGLMTGLYTAAMGLGAALAAGLTVPLAA------ALGWRGALAVWALLALLALLLWLPLLRRRP 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 180 SDAkwltreeqvwlttalkreedvktQGVTTHPKMSTAFTSGRVWMLSFVYFGFIYGLYALAFFLPTIIE--GFQEQYGt 257
Cdd:COG2807 197 AAA-----------------------AAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRdaGLSAATA- 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 258 tfgifekGLITAIPYVPAAIALYLWSRDATRRGVRTWHIVIPAIAGGLSIPLALFAGSPAATIAVITVTAMAIFSALPNF 337
Cdd:COG2807 253 -------GLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLAL 325
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2269430540 338 WTFPTRFLTGAAAAAGIALINTVGNLAGFSAPYITGALRDATGGYEVPMFIVGFFLLLSAVLMALLARRYKDAP 411
Cdd:COG2807 326 TLIGLRARTPAEAAALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLLAGRPYVEDA 399
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
3-375 |
8.81e-16 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 78.55 E-value: 8.81e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 3 FINYLDRTAIGFAAPnGMEADLALSAAQFGFASGVFFIGYILLEVPSNLALHRFGARRWLARIMVSWGIVALLFTWVQNF 82
Cdd:TIGR00895 27 LMDGYDLAAMGFAAP-AISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNV 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 83 EQLVALRFLLGVAEAGFFPGAILFLSLWVPAKHRSKILALFYLAQPLTTVIGAPLAGFLIEQdgilglEGWRFMFLGVSL 162
Cdd:TIGR00895 106 TQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPV------FGWRSLFYVGGI 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 163 PAIVVGVIAWFYLkdkPSDAKWLTREEQVWLTTALKREEDVKTQGVTTHPKMSTAF---------------TSGRVWMLS 227
Cdd:TIGR00895 180 APLLLLLLLMRFL---PESIDFLVSKRPETVRRIVNAIAPQMQAEAQSALPEQKSTqgtkrsvfkalfqgkTARITVLLW 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 228 FVYFGFIYGLYALAFFLPTIIEgfqeqyGTTFGIFEKGLITAIPYVPAAIALYLWSRDATRRGVRTWhIVIPAIAGGLSI 307
Cdd:TIGR00895 257 LLYFMLLVGVYFLTNWLPKLMV------ELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVT-ALLLLLGAVFAV 329
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2269430540 308 PLALFAGSPAATIAVITVTAMAIFSALPNFWTFPTRFLTGAAAAAGIALINTVGNLAGFSAPYITGAL 375
Cdd:TIGR00895 330 LVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGYL 397
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
55-404 |
3.41e-15 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 76.46 E-value: 3.41e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 55 RFGARRWLARIMVSWGIVALLFTWVQNFEQLVALRFLLGVAEAGFFPGAILFLSLWVPAKHRSKILALFYLAQPLTTVIG 134
Cdd:cd17473 61 RFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVF 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 135 APLAGFLIEQdgilgleGWRFMFLgVSLPAIVVGVIAWFYLKDKpsdakwltreeqvwlttalkreEDVKTQGVTTHPKM 214
Cdd:cd17473 141 LLLGGALAEI-------GWRAPFL-VYLLALPVLILVLLFLPEP----------------------ARKSKSAASPGAAT 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 215 STAFTSGRVWMLSFVYFGFIYGLYALAFFLPTIIEGFqeQYGTTFGIfekGLITAIPYVPAAIALYLWSRDATRRGVRtW 294
Cdd:cd17473 191 AAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQER--GGGSAALI---GLALAIASLAGAIGALLFGRLKRRLGKR-R 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 295 HIVIPAIAGGLSIPLALFAGSPAATIAVITVTAMAIFSALPNFWTFPTRFLTGAAAAAGIALINTVGNLAGFSAPYITGA 374
Cdd:cd17473 265 LLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGP 344
|
330 340 350
....*....|....*....|....*....|
gi 2269430540 375 LRDATGGYEVPMFIVGFFLLLSAVLMALLA 404
Cdd:cd17473 345 LVNLTGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
1-176 |
9.08e-15 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 75.28 E-value: 9.08e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 1 MFFINYLDRTAIGFAAPNgMEADLALSAAQFGFASGVFFIGYILLEVPSNLALHRFGARRWLARIMVSWGIVALLFTWV- 79
Cdd:cd17380 7 ATCICYADRVNMPIAIVP-MAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLa 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 80 -QNFEQLVALRFLLGVAEAGFFPGAILFLSLWVPAKHRSKILALFYLAQPLTTVIGAPLAGFLIEQDgilgleGWRFMFL 158
Cdd:cd17380 86 ySSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYY------GWPSVFY 159
|
170
....*....|....*...
gi 2269430540 159 GVSLPAIVVGVIAWFYLK 176
Cdd:cd17380 160 FFGLLGLLWALVWLIYLP 177
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
8-404 |
1.04e-14 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 75.35 E-value: 1.04e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 8 DRTAIGFAAPNGMEADLALSAAQFGFASGVFFIGYILLEVPSNLALHRFGARRWLARIMVSWGIVALLFTWVQNF--EQL 85
Cdd:cd17318 35 NNTSTDKDTLPVEAPEFDWSEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGgyGAL 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 86 VALRFLLGVAEAGFFPGAILFLSLWVPAKHRSKILALFYLAQPLTTVIGAPLAGFLIEQdgilglEGWRFMFLgVSLPAI 165
Cdd:cd17318 115 IVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCES------LGWPSIFY-IFGGLG 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 166 VVGVIAWFYLkdkpsdakwltreeqvwlttalkreedvktqgvtthpkmstaftSGRVWMLSFVYFGFIYGLYALAFFLP 245
Cdd:cd17318 188 LLWCLLWFFL--------------------------------------------VLPVWAIVVAHFGHNWGFYTLLTELP 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 246 TIIEgfqEQYGttFGIFEKGLITAIPYVPAAIALYL-------------WSRDATRRGVRTWHIVIPAIAGglsIPLALF 312
Cdd:cd17318 224 TYMS---DVLH--FNIKSNGFLSSLPYLAMWICSIVggyladwlrsrgiLSTTTVRKLFTSIGFLGPGVFL---IALGYL 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 313 AGSPAATIAVITVtAMAIFSAL------------PNFWTFptrfltgaaaaaGIALINTVGNLAGFSAPYITGAL---RD 377
Cdd:cd17318 296 GSNATLAVVFLTL-SVGLSGACysgflvnhldlaPNYAGT------------LMGITNTAATIAGIISPLIVGAIvknDQ 362
|
410 420
....*....|....*....|....*..
gi 2269430540 378 ATGGYEVPMFIVGFFLLLSAVLMALLA 404
Cdd:cd17318 363 TIGQWRIVFFISAAIYILGAIFYLIFG 389
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
4-338 |
1.21e-13 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 71.88 E-value: 1.21e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 4 INYLDRTAIGFAAPNgMEADLALSAAQFGFASGVFFIGYILLEVPSNLALHRFGaRRWLARI-MVSWGIVALLFTWVQNF 82
Cdd:cd17328 10 LNYMDRFTIAGVLPD-IQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYN-RKWILAVgILIWSAATLLSSFAPNF 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 83 EQLVALRFLLGVAEAGFFPGAILFLSLWVPAKHRSKILALFYLAQPLTTVIGAPLAGFLIEQDGilgleGWRFMFLGVSL 162
Cdd:cd17328 88 WQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATG-----GWRWAFRVTGV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 163 PAIVVGVIAWFYLKDKPSdakwltreeqvwltTALKREEDVKTQGVTTHPKMSTAFTSGRVWMLSFVYFGFIYGLYALAF 242
Cdd:cd17328 163 LGVLLAILLLLFVREPPR--------------GAAEGGVMAKSTATSFLADLKALAKNPSFILSTLGFTAVSFVTGALAF 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 243 FLPTIIEGFQEQYGTTFGI--FEKGLITAIPYVpAAIALYLWSRDATRRGVRTWHIVIPAIAGGLSIPLALFAGSPAATI 320
Cdd:cd17328 229 WAPTFFLRAFGVGDLSSADvgLIFGAITCIAGV-LGVLLGGILADRLRRKTPRADPLVCAVGLLAAAPFLFLALVLALSN 307
|
330
....*....|....*...
gi 2269430540 321 AVITVTAMAIFSALPNFW 338
Cdd:cd17328 308 LLLAWVLLFLGEFLLSLN 325
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
22-394 |
2.95e-13 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 70.66 E-value: 2.95e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 22 ADLALSAAQFGFASGVFFIGYILLEVPSNLALHRFGARRWLARIMVSWGIVALLFTWVQNFEQLVALRFLLGVAEAGFFP 101
Cdd:cd17324 27 RDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 102 GAILFLSLWVPAKHRSKILALFYLAQPLTTVIGAPLAGFLIEqdgilgLEGWRFMFLGVSLPAIVVGVIAWFYLKDKPSD 181
Cdd:cd17324 107 IAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQ------LLGWRAAFLAIAVLALLAALLLWRLLPSLPPK 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 182 AKwltreeqvwLTTALKREEdvktqgvtthpkmSTAFTSGRVWMLSFVYFGFIYGLYALAFFLPTIIEGFQEQYGTTFgi 261
Cdd:cd17324 181 KP---------GSLGLLSSL-------------LLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAI-- 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 262 fekGLITAIPYVPAAIALYLWSRDATRRGVRTwHIVIPAIAGGLSIPLALFAGSPAATIAVITVTAMAIFSALPNFWTFP 341
Cdd:cd17324 237 ---IGLLLLFGVAGVVGSPLAGRLADRGGRRA-LLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRV 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 2269430540 342 TRfLTGAAAAAGIALINTVGNLAGFSAPYITGALRDATGGYEVPMFIVGFFLL 394
Cdd:cd17324 313 LR-LAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLL 364
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
2-380 |
5.18e-13 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 70.10 E-value: 5.18e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 2 FFINYLDRTAIGFAAPNgMEADLALSAAQFGFASGVFFIGYILLEVPSNLALHRFGARRWLARIMVSWGIVALLFTWVQN 81
Cdd:TIGR00881 4 YAAYYLVRKNFALAMPY-LVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 82 FEQLVALRFLLGVAEAGFFPGAILFLSLWVPAKHRSKILALFYLAQPLTTVIGAPLAGFLIEQdgilgLEGWRFMFLGVS 161
Cdd:TIGR00881 83 LWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAE-----LYSWHWVFIVPG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 162 LPAIVVGVIAWFYLKDKPSDAKwLTREEQvWLTTALKREEDVKTQGVTT-HPKMSTAFTSGRVWMLSFVYFgFIYGLYA- 239
Cdd:TIGR00881 158 IIAIIVSLICFLLLRDSPQSCG-LPPAEE-MPNEEPDGDAEKKEEELTKkQIFLQYVLLNKVLWYISLGYV-FVYVVRTg 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 240 ----LAFFLPTIIEGFQEQYGTTFGIFEKGLItaipyVPAAIALYLWSRDATRRGVRTWHIVIPAIAGGLSIPLALFAGS 315
Cdd:TIGR00881 235 ildwSPLYLTQEKGFSKEKASWAFTLYELGGL-----VGTLLAGWLSDKLFNGRRGPLAVFFMALIIVSLLVYWLNPAAN 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2269430540 316 PAATIAVITVTAMAIFSALPNFWTFPTRFLTGAAAAAGIALINTVGNLAGFSAPYITGALRDATG 380
Cdd:TIGR00881 310 PLMDLICLFALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFG 374
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
11-401 |
2.67e-12 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 67.65 E-value: 2.67e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 11 AIGFAAPNgMEADLALSAAQFGFASGVFFIGYILLEVPSNLALHRFGARRWLARIMVSWGIVALLFTWVQNFEQLVALRF 90
Cdd:cd17475 14 GIPALAPF-LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 91 LLGVAEAGFFPGAILFLSLWVPAKHRSKILALFYLAQPLTTVIGAPLAGFLIEQdgilglEGWRFMFLGVSLPAIVVGVI 170
Cdd:cd17475 93 LVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALH------YGWRAAFVVAGLVSILAAVL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 171 AWFYLKDkPSDAKWLTREEQVWLTTAlkreedvktqgvtthpkmSTAFTSGRVWMLSFVYFGFIYGLYALAFFLptiIEG 250
Cdd:cd17475 167 FWLFYRE-PPAASAATESASTLLRSL------------------KEVLRNRDVWLIAIAGALLVAPQFALLTFL---LLF 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 251 FQEQYGttFGIFEKGLITAIPYVPAAIALYLWSR--DATRRGVRTWHIVIPAIAGGLSIPLALF--AGSPAATIA-VITV 325
Cdd:cd17475 225 LHDHLG--LSVVAAGALLAVAQLGGALGRIGLGRvsDRVFGGRRRPVLVITAAIAAAALLVLSLlsPGTPLWLLVlLLIL 302
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2269430540 326 TAMAIFSALPNFWTFPTRFLTGAAAAAGIALINTVGNLAGFSAPYITGALRDATGGYEVPMFIVGFFLLLSAVLMA 401
Cdd:cd17475 303 LGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLLL 378
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
7-406 |
2.94e-12 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 67.61 E-value: 2.94e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 7 LDRTAIGFAAPnGMEADLALSAAQFGFASGVFFIGYILLEVPSNLALHRFGARRWLARIMVSWGIVALLFTWVQNFEQLV 86
Cdd:cd17365 13 FDLAVMGFVAP-ALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 87 ALRFLLGVAEAGFFPGAILFLSLWVPAKHRSKILALFYLAQPLTTVIGAPLAGFLIEQdgilglEGWRFMFLGVSLPAIV 166
Cdd:cd17365 92 LLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPA------FGWRSVFLLGGVPPLI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 167 VGVIAWfylkdkpsdakwltreeqvwlTTALkreedvktqgvtthpkmstaftsgrVWMLSFVYFGFIYGLYAlafFLPT 246
Cdd:cd17365 166 LLPLLR---------------------GTLL-------------------------LWVTFFMGLLLVYLLNS---WLPK 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 247 IIEgfqeqyGTTFGIFEKGLITAIPYVPAAIALYLWSRDATRRGVRTWHIVIPAIAGGLSIPLALFAGSPAATIAVITVT 326
Cdd:cd17365 197 LMV------EAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPASLVLLYVLVFLA 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 327 AMAIFSALPNFWTFPTRFLTGAAAAAGIALINTVGNLAGFSAPYITGALRDATGGYEVPMFIVGFFLLLSAVLMALLARR 406
Cdd:cd17365 271 GACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAAGLGPESVFLALAIPAALGALAVLLLRLR 350
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
27-375 |
7.65e-12 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 66.69 E-value: 7.65e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 27 SAAQFGFASGVFFIGYILLEVPSNLALHRFGARRWLARIMVSWGIVALLFTWV--QNFEQLVALRFLLGVAEAGFFPGAI 104
Cdd:TIGR00894 74 SGALQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAagGGIALVVFCRVIQGLAQGSVSPATH 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 105 LFLSLWVPAKHRSKILALFYLAQPLTTVIGAPLAGFLIEQDGilgleGWRFMFLGVSLPAIVVGVIAWFYLKDKPSDAKW 184
Cdd:TIGR00894 154 KIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCESWG-----GWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPC 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 185 LTREEQVWLTTALkreedVKTQGVTTHPKMSTA-FTSGRVWMLSFVYFGFIYGLYALAFFLPTIIegfqeQYGTTFGIFE 263
Cdd:TIGR00894 229 ISKFEKKYINSSL-----QGQKGSTRQSLPIKAiPKSLPVWAIWFAIFGHFWLYTILPTYLPTFI-----SWVLRVSGKE 298
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 264 KGLITAIPYVPAAI----ALYLWSRDATRR-GVRTWHIVIPAIAGGLSIPLALFAGSPAATIAVITVTAMAIFSALPNFW 338
Cdd:TIGR00894 299 NGLLSSLPYLFAWLcsifAGYLADFLKSSKtLSLTAARKIFNGIGGLGPGIFAYALPYLSAAFYLTIIILTLANAVSSGP 378
|
330 340 350
....*....|....*....|....*....|....*..
gi 2269430540 339 TFPTRFLTGAAAAAGIALINTVGNLAGFSAPYITGAL 375
Cdd:TIGR00894 379 LAGVLINSLDLAPRFLGFIKGITGLPGFIGGLIASTL 415
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
2-401 |
3.63e-11 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 64.16 E-value: 3.63e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 2 FFINYLDRTAIGFAAPN-GMEADLALSAAQFGFASGVFFIGYILLEVPSNLALHRFGARRWLARIMVSWGIVALLFTWVQ 80
Cdd:cd17316 8 WFFDAYDFFLIGFVAPVlAAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLP 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 81 NFEQLVALRFLLGVAEAGFFPGAILFLSLWVPAKHRSKILALFYLAQPLTTVIGAPLAGFLIeqDGILGLEGWRFMFLGV 160
Cdd:cd17316 88 TPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLI--PLLSGDWGWRILFLIG 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 161 SLPAIVVGVIAWfylkdkpsdakwltreeqvwlttalkreedvktqgvtthpkmstaftsgRVWMLSFVYFGFIYGLYAL 240
Cdd:cd17316 166 ALPALLALLLRR-------------------------------------------------RTLLLILLWFFISFGYYGL 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 241 AFFLPTIIegfqeQYGTTFGIFEKGLITAIPYVPAAIALYLWSRDATRRGVRTWhIVIPAIAGGLSIPLALFAGSPAATI 320
Cdd:cd17316 197 TTFLPTYL-----QTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKT-LVIGLILSGILALPLFYLLSGSPTL 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 321 AVITVTAMAIFSALPN--FWTFPTRFLTGAAAAAGIALINTVGNLAGFSAPYITGALRDATGGYEVPMFIVGFFLLLSAV 398
Cdd:cd17316 271 LLLLLFILSFFVGGVWgaLYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALI 350
|
...
gi 2269430540 399 LMA 401
Cdd:cd17316 351 VAL 353
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
2-402 |
4.64e-11 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 63.81 E-value: 4.64e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 2 FFINYLDRTAIGFAAPNgMEADLALSAAQFGFASGVFFIGYILLEVPSNLALHRFGARRWLARIMVSWGIVALLFTW-VQ 80
Cdd:cd17341 8 FFLGFMVWFLFAPLGPV-IRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALaVS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 81 NFEQLVALRFLLGVAEAGFFPGaILFLSLWVPAKHRSKILALFY----LAQPLTTVIGAPLAGFLIEQDGILgleGWRFM 156
Cdd:cd17341 87 SYWGLLVLGFLLGFAGANFASG-QPWASFWFPKEKIGGAAGGIAgagnMGVAVSQLLAPLIAGAIVFDGGFV---GWRNA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 157 FLGVSLPAIVVGVIAWFYLKDKPsdakwltreeqvwlttalkreeDVKTQGVTTHPKMSTAFTSGRVWMLSFVYFGFIYG 236
Cdd:cd17341 163 FFVPGILLAIAAVLVLLFGDDLP----------------------TGKASALEFLKVQLAVLKNYRTWILSLLYGVTFGS 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 237 LYALAFFLPTIiegFQEQYGttFGIFEKGLITAIPYVPAAIALYLWSRDATRRG--VRTWHIVIPAIAGGLSIPLALFAG 314
Cdd:cd17341 221 FVGFSNVLPTY---FKTRFG--LPLVTAGILAALFPLAGALARPAGGWLSDRFGgrRRLWWLFIVMTIGAALLSLSLPTS 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 315 SPAATIAVITVTAMAIFSALPNFWTFP-TRFLTGAAAAAGIALINTVGNLAGFSAPYITGALRDATGGYEVPMFIVGFFL 393
Cdd:cd17341 296 GTNLVLFLALFVALGLGAGAGNGSVFRmVPFIFRRELGAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAFSLFGVLA 375
|
....*....
gi 2269430540 394 LLSAVLMAL 402
Cdd:cd17341 376 VACTLLVWL 384
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
20-403 |
1.36e-10 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 62.59 E-value: 1.36e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 20 MEADLALSAAQFGFASGVFFIGYILLEVPSNLALHRFGARRWLARIMVSWGIVALLFTWVQNFEQLVALRFLLGVAEAGF 99
Cdd:cd17474 25 IAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 100 FPGAILFLSLWVPAKHRSKILALFYLAQPLTTVIGaPLAGflieqdGILGLEGWRFMFLGVSLpAIVVGVIAWFYLKDKP 179
Cdd:cd17474 105 GPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVG-PLLG------GLLAAISWRYPFFLLAA-LIPVAFLAILFLLPEP 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 180 SdakwltreeqvwlttalkreEDVKTQGVTTHPKMSTAFTSGRVWMLSFVYFGFIYGLYALAFFLPTIIEGFQEQYGttf 259
Cdd:cd17474 177 K--------------------EKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISP--- 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 260 giFEKGLITAIPYVPAAIALYLWSRDATRRGVRTWHIVIPAIAGGLSIPLALFAGSPAATIAVITVTAMAIFSALPNFWT 339
Cdd:cd17474 234 --IIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTT 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2269430540 340 FPTRFLTGAAAAAGIALINTVGNLAGFSAPYITGALRDAtGGYEVPMFIVGFFLLLSAVLMALL 403
Cdd:cd17474 312 LVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEI-FGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
23-337 |
2.07e-10 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 61.84 E-value: 2.07e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 23 DLALSAAQFGFASGVFFIGYILLEVPSNLALHRFGARRWLARIMVSWGIVALLFTWVQNFEQLVALRFLLGVAEAGFFPG 102
Cdd:cd17489 25 DLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 103 AILFLSLWVPAKHRSKILALFYLAQPLTTVIGAPLAGFLIeqdgilGLEGWRFMFLGVSLPAIVVGVIAWFylkdkpsda 182
Cdd:cd17489 105 AATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLY------QHLGFAVLFIVAAVLALLALLLVFL--------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 183 kwltreeqvwlttaLKREEDVKTQGVTTHPKMSTAFTSGRVWMLSFVYFGFIYGLYALAFFLPT-IIEGFQEQYGTTFGI 261
Cdd:cd17489 170 --------------VKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLyAAERGISNAGLFFTV 235
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2269430540 262 FekglitaipyvpaAIALYLW---SRDATRRGVRTWHIVIPAIAGGLSIPLALFAGSPAATIAVITVTAMAIFSALPNF 337
Cdd:cd17489 236 Y-------------AIALLLSrpfSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPAL 301
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
2-251 |
7.28e-10 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 59.82 E-value: 7.28e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 2 FFINYLDRTAIGFAAPNgMEADLALSAAQFGFASGVFFIGYILLEVPSNLALHRFGARRWLARIMVSWGIVALLFTWVQN 81
Cdd:COG0477 23 TFLEGLDFTIVNVALPS-IAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPS 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 82 FEQLVALRFLLGVAEAGFFPGAILFLSLWVPAKHRSKILALFYLAQPLTTVIGAPLAGFLIEqdgilgLEGWRFMFLGVS 161
Cdd:COG0477 102 PELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVA------ALGWRWIFLINA 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 162 LPAIVVGVIAWFYLKDKPSDAKWLTREEQVWLTTALKREEDVKTQGVTTHPKMSTAFTSGRVWMLSFVYFGFIYGLYALA 241
Cdd:COG0477 176 PLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLA 255
|
250
....*....|
gi 2269430540 242 FFLPTIIEGF 251
Cdd:COG0477 256 LLLLAALLLL 265
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
55-399 |
6.41e-09 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 57.31 E-value: 6.41e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 55 RFGARRWLARIMVSWGIVALLFTWVQNFEQLVALRFLLGVAEAGFFPGAILFLSLWVPAKHRSKILALFYLAQPLTTVIG 134
Cdd:cd17371 60 RFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLA 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 135 APLAGFLIEQdgILGLEGWRFMFLGVSLPAIVVGVIAwFYLKDKPSdakwltreeqvWLTTALKReedvktQGVTTHPKM 214
Cdd:cd17371 140 TLLAALLFPL--LPPEIAWRVLFLLGALPALLVLFIR-RFVKEPPQ-----------WQAARAAR------RHFADRPSL 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 215 STAFTSG--RVWMLSFVYFGFIY-GLYALAFFLPTIIEGFQEQygttfgIFEKGLITAIPYVPAAIALYLWSRDATRRGV 291
Cdd:cd17371 200 RELFSPPllRTTLLASLLATGALgGYYGITTWLPSYLTGERGL------SFEGSAGYLVVTILGGFLGYLAGGFLADRIG 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 292 RTWHIVIPAIAGGLSIPLALFAGSPAATIAVITV----TAMAIFSALPNFWT--FPTRFLTGAAAAagialINTVGNLAG 365
Cdd:cd17371 274 RRNNFALFALGSAISILLYFFLPLSPTLILILGFplgfFASGPFSGMGAYLTelFPTAVRATAQGF-----CYNVGRIIG 348
|
330 340 350
....*....|....*....|....*....|....*.
gi 2269430540 366 FSAPYITGALRDA--TGGYEVPMFIVGFFLLLSAVL 399
Cdd:cd17371 349 ALFPFLVGFLATSgsLGTAIAVFAAVYYIAGLVLAL 384
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
1-175 |
6.92e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 57.20 E-value: 6.92e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 1 MFFINYLDRTAIGFAAPNGMEADLALSAAQFGFASGVFFIGYILLEVPSNLALHRFGARRWLARIMVSWGIVALLFTWVQ 80
Cdd:cd17325 207 AIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLAT 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 81 NFEQLVALRFLLGVAEAGFFPGAILFLSLWVPAKHRSKILALFYLAQPLTTVIGAPLAGFLIEqdgilgLEGWRFMFLGV 160
Cdd:cd17325 287 SFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYD------AFGFATPFLAA 360
|
170
....*....|....*
gi 2269430540 161 SLPAIVVGVIAWFYL 175
Cdd:cd17325 361 AALLLLAAVLFLLLR 375
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
20-410 |
7.50e-09 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 57.17 E-value: 7.50e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 20 MEADLALSAAQFGFASGVFFIGYILLEVPSNLALHRFGARRWLARIMVSWGIVALLFTWVQNFEQLVALRFLLGVAeAGF 99
Cdd:COG0738 34 LKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLG-LGL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 100 FPGAILFLSLWVPAKHRSKILALFYLAQPLTTVIGAPLAGFLIEQDGILgleGWRFMFLGVSLPAIVVGVIAWFylkdkp 179
Cdd:COG0738 113 LDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSL---SWHLPYLILAVLLLLLALLFLR------ 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 180 sdakwltreeqvwltTALKREEDVKTQGVTTHPKMSTAFTSGRVWMLSFVYFGFIYGLYALAFFLPTIiegFQEQYGTTF 259
Cdd:COG0738 184 ---------------SKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLY---LKDVLGLSE 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 260 GIFekGLITAIPYVPAAIALYLWSRDATRRGVRTWhIVIPAIAGGLSIPLALFAGSPAatIAVITVTAMAIFSAL--PNF 337
Cdd:COG0738 246 ATA--ALGLSLFWGGMTIGRFLGGFLLKRFGPVRL-LRLSALLAAVGLLLALLAPGPW--LALIGLALVGLGLSLmfPTI 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2269430540 338 WTFPTRFLTGAAAAAGIALInTVGNLAGFSAPYITGALRDATGGYEVPMFIVGFFLLLsaVLMALLARRYKDA 410
Cdd:COG0738 321 FSLALDGLGKRTAAAVSAVL-IMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLI--LLLALALKRKRRK 390
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
19-402 |
8.40e-09 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 56.93 E-value: 8.40e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 19 GMEADLALSAAQFGFASGVFFIGYILLEVpsnlaLHRFGARRWLARIMVSWGIVALLF-----TWVQNFEQLVALRFLLG 93
Cdd:cd06180 24 LMLAELGLSYAQAGWIATANYAGYLVGAL-----LASFLRRRGRARRLIRGGLLLTVLllaamALTSGFAALLALRFLAG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 94 VAEA-GFFPGAILFLSlWVPAKHRSKILALFYLAQPLTTVIGAPLAGFLIEqdgilGLEGWRFMFLGVSLPAIVVGVIAW 172
Cdd:cd06180 99 AASAfVFVFGSNLVLH-HATAAGRGHLIGLLFAGVGLGIALSGLLVPAGLG-----GGLSWRAGWLALALLSAVLLLLSF 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 173 FYLKDKPSDAkwltreeqvwlttalkreedvktqgVTTHPKMSTAFTSGRVWMLSFVYFGFIYGLYALAFFLPTIIEgfq 252
Cdd:cd06180 173 LLLRRGPSAP-------------------------TEASAAESAPGLNRPLWRLALAYGLFGFGYIITATFLPLIAR--- 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 253 eqyGTTFGIFEKGLITAIPYVPAAIALYLWSRDATRRGVRTWHIVIPAIaGGLSIPLALFAGSPAATIAVITVTAMAiFS 332
Cdd:cd06180 225 ---ETGAGSLLAGLLWSLFGLAAVPSCFLWGALSDRWGTRRALAANLLV-QAVGVLLPLLSPGPAGLVLSAVLFGGT-FM 299
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 333 ALPNFWTFPTRFLTGAAAAAGIALINTVGNLAGFSAPYITGALRDATGGYEVPMFIVGFFLLLSAVLMAL 402
Cdd:cd06180 300 AITALVMALARELAPPAAPRALALMTASFGVGQILGPLLAGWLADATGGFAPALILAAAALVVAALLALL 369
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
2-256 |
3.03e-08 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 55.00 E-value: 3.03e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 2 FFINYLDRTAIGFAAPNGMEADLALSAAQFGFASGVFFIGYILLEVPSNLALHRFGARRWLARIMVSWGIVALLFTWV-Q 80
Cdd:TIGR00886 10 FFLSFLVWFAFSPLAVFLIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAvQ 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 81 NFEQLVALRFLLGVAEAGFFPgAILFLSLWVPAKHRSKILALF----YLAQPLTTVIGAPLAGFLIEQDGILGLEGWRFM 156
Cdd:TIGR00886 90 SYSVLLLIRLFIGIAGGSFAS-CMPWISFFFPKKIQGTALGLAagwgNMGGGVAQFVMPPIIGSLIFGGGQPAHLAWGWA 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 157 F-LGVSLPAIVVGVIAWFYLKDKPSDAKwltreeqvwLTTALKREEDVKtqgvtthpkmstAFTSGRVWMLSFVYFGFIY 235
Cdd:TIGR00886 169 FvIVPAGILLLPALLIFFVGADTPPGKP---------ATGKLSFKEALK------------VFGNRHTWILALLYSVTFG 227
|
250 260
....*....|....*....|.
gi 2269430540 236 GLYALAFFLPTIiegFQEQYG 256
Cdd:TIGR00886 228 SFLGVSSIFAML---FKDQFG 245
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
20-399 |
1.89e-07 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 52.66 E-value: 1.89e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 20 MEADLALSAAQFGFASGVFFIGYILLEVPSNLALHRFGARRWLARIMVSWGIVALLFTWVQNFEQLVALRFLLGVAEAG- 98
Cdd:cd17355 29 IIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGt 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 99 FFPGAILFLSLWVPAKHRSKILALFYLAQPLTTVIGAPLAGFLIEQDGilglegWRFMFLGVSLPAIVVGVIAWFYLKDK 178
Cdd:cd17355 109 LAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFG------WRTALLVLALLALLVLVPVLLLLRRR 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 179 PSDAKWLTREEQVWLTTALKREEdvktqgvtthpkmstAFTSGRVWMLSFVYFGFIYGLYALAFFLPTIIEGFQEQYGTT 258
Cdd:cd17355 183 PADLALRAYDDASPASPGSTLKE---------------ALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAA 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 259 FGIFekGLItAIPYVPAAIALYLWSRDATRRGVRTWHIVIPAIAGGLsipLALFAGSPAATIAVITVTAMAIFSALPNFW 338
Cdd:cd17355 248 AVAL--ALI-GLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLAL---LLLLPFPPLALLLFAALFGLGWGATVPLTA 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2269430540 339 TFPTRFLTGAAAAAGIALINTVGNLAGFSAPYITGALRDATGGYEVPMFIVGFFLLLSAVL 399
Cdd:cd17355 322 ALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALL 382
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
6-179 |
2.55e-07 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 52.28 E-value: 2.55e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 6 YLDRTAIGFAAPnGMEADLALSAAQFGFASGVFFIGYILLEVPSNLALHRFGARRWLARIMVSWGIVALLFTWVQNFEQL 85
Cdd:cd17312 16 YVCRKNFSVAKP-PIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFF 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 86 VALRFLLGVAEAGFFPGAILFLSLWVPAKHRSKILALFYLAQPLTTVIGAPLAGFLIeqdgilGLEGWRFMFLGVSLPAI 165
Cdd:cd17312 95 AVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLA------SYYGWRAAFLVPGIVGL 168
|
170
....*....|....
gi 2269430540 166 VVGVIAWFYLKDKP 179
Cdd:cd17312 169 VVAIILFFFLRDSP 182
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
32-141 |
7.39e-07 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 50.93 E-value: 7.39e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 32 GFASGVFFIGYILLEVPSNLALHRFGARRWLARIMVSWGIVALLFTWVQNF--EQLVALRFLLGVAEAGFFPGAILFLSL 109
Cdd:cd17381 68 GWILGSFFYGYIITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLgaGYLIAVRALEGLGEGVTFPAMHAMWAS 147
|
90 100 110
....*....|....*....|....*....|..
gi 2269430540 110 WVPAKHRSKILALFYLAQPLTTVIGAPLAGFL 141
Cdd:cd17381 148 WAPPLERSRLLTISYAGAQLGTVVSLPLSGLI 179
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
2-185 |
9.07e-07 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 50.72 E-value: 9.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 2 FFINYLDRTaigFAAPNGMEADLALSAAQFGFASGVFFIGYILLEVPSNLALHRFGaRRWLARIMVSWGIVALLFT---- 77
Cdd:cd17357 25 VFKEFINDT---LVDRYGLNLSDSELDLLWSLIVSIFFIGGAIGSFISAFLANRFG-RKNGLLISNALLVVSSLLMflsk 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 78 WVQNFEQLVALRFLLGVAEAGFFPGAILFLSLWVPAKHRSKILALFYLAQPLTTVIGAplagfLIEQDGILGLE-GWRFM 156
Cdd:cd17357 101 SAKSPELLIFGRFLVGIACGLSTGFVPMYLQEISPSELRGALGSLTQIGVTLGILLGQ-----VFGLPSVLGTEtLWPYL 175
|
170 180
....*....|....*....|....*....
gi 2269430540 157 FLGVSLPAIVVGVIAWFYlkdkPSDAKWL 185
Cdd:cd17357 176 LFFPGIPALLQLAALPFF----PESPKFL 200
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
7-173 |
1.03e-06 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 50.35 E-value: 1.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 7 LDRTAIGFAAPnGMEADLALSAAQFGFASGVFFIGYILLEVPSNLALHRFGARRWLARIMVSWGIVALLFTWVQNFEQLV 86
Cdd:PRK11551 29 LDLQSAGVAAP-RMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 87 ALRFLLGVAEAGFFPGAILFLSLWVPAKHRSKILALFYLAQPLTTVIGAPLAGFLIeqdgilGLEGWRFMF-LGVSLPAI 165
Cdd:PRK11551 108 VARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAA------GDAAWRHIFyVGGVGPLL 181
|
....*...
gi 2269430540 166 VVGVIAWF 173
Cdd:PRK11551 182 LVPLLMRW 189
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
6-179 |
1.75e-06 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 49.93 E-value: 1.75e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 6 YLDRTAIGFAAPNGMEAdLALSAAQFGFASGVFFIGYILLEVPSNLALHRFGARRWLARIMVSWGIVALLFTWVQ----N 81
Cdd:cd17345 16 YLVRNNFSLAQPYLIEQ-YGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVPsatsS 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 82 FEQLVALRFLLGVAE-AGFFPGAILfLSLWVPAKHRSKILALFYLAQPLTTVIGAPLAGFLIeqdGILGLEGWRFMFLGV 160
Cdd:cd17345 95 VGLMFILLFLNGWFQgMGWPPSGRT-MVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGL---AIFGDGWWRGAFIFP 170
|
170
....*....|....*....
gi 2269430540 161 SLPAIVVGVIAWFYLKDKP 179
Cdd:cd17345 171 AIIAIIVAVIVLFLGKDTP 189
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
7-170 |
4.28e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 48.32 E-value: 4.28e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 7 LDRTAIGFAAPnGMEADLALSAAQFGFASGVFFIGYILLEVPSNLALHRFGARRWLARIMVSWGIVALLFTWVQNFEQLV 86
Cdd:cd17321 10 LDVTIVNVALP-TIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLI 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 87 ALRFLLGVAEAGFFPGAILFLSLWVPAKHRSKILALFYLAQPLTTVIGAPLAGFLIEqdgilgLEGWRFMFLgVSLPAIV 166
Cdd:cd17321 89 AARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLE------LFGWRWIFL-INVPIGL 161
|
....
gi 2269430540 167 VGVI 170
Cdd:cd17321 162 VALL 165
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
22-185 |
4.88e-06 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 48.47 E-value: 4.88e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 22 ADLALSAAQFGFASGVFFIGYILlevpsnlalHRFGARRWLARIMVSWGIVALLFTWVQNFEQLVALRFLLGVAEAGFFP 101
Cdd:TIGR00898 129 VDLTQSCFFVGVLLGSFVFGYLS---------DRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWV 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 102 GAILFLSLWVPAKHRSKILALFYLAQPLTTVIGAPLAGFlieqdgilgLEGWRFMFLGVSLPAIVVGVIAWFYlkdkPSD 181
Cdd:TIGR00898 200 QAVVLNTEFLPKKQRAIVGTLIQVFFSLGLVLLPLVAYF---------IPDWRWLQLAVSLPTFLFFLLSWFV----PES 266
|
....
gi 2269430540 182 AKWL 185
Cdd:TIGR00898 267 PRWL 270
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
10-173 |
5.97e-06 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 47.95 E-value: 5.97e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 10 TAIGFAAPNGMEADLALSAAQFGFASGVFFIGYILLEVPSNLALHRFGARRWLARIMVSWGIVALLFTWVQNFEQLVALR 89
Cdd:cd17359 17 TGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIAR 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 90 FLLGVAEAGFFPGAILFLSLWVPAKHRSKILALFYLA----QPLTTVIGAPLAGFLieQDGILGLEGWRFMFLGVSLPAI 165
Cdd:cd17359 97 IIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMivfgQLLAYIVNYLIANAG--GADWLGAEGWRWMLGLEAIPAI 174
|
....*...
gi 2269430540 166 VVGVIAWF 173
Cdd:cd17359 175 LFLLGMLF 182
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
3-179 |
2.53e-05 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 46.22 E-value: 2.53e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 3 FINYLDRTAIGFAAPNGMeADLALSAAQFGFASGVFFIGYILLEVPSNLALHRFGARRWLARIMVSWGIVALLFTWVQNF 82
Cdd:TIGR00711 12 FMAVLDSTIVNVAIPTIA-GDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 83 EQLVALRFLLGVAEAGFFPGAILFLSLWVPAKHRSKILALFYLAQPLTTVIGAPLAGFLIEqdgilgLEGWRFMFLGVSL 162
Cdd:TIGR00711 91 ELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIE------NYHWRWIFLINVP 164
|
170
....*....|....*...
gi 2269430540 163 PAIVVGVIAWFYLK-DKP 179
Cdd:TIGR00711 165 IGIIVVVVAFFILPrDKP 182
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
24-173 |
3.06e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 45.68 E-value: 3.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 24 LALSAAQFGFASGVFFIGYILLEVPSNLALHRFGARRWLARIMVSWGIVALLFTWVQNFEQLVALRFLLGVAEAGFFPGA 103
Cdd:cd06173 239 LGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPL 318
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 104 ILFLSLWVPAKHRSKILALFYLAQPLTTVIGAPLAGFLIEQDGIlglegwRFMFLGVSLPAIVVGVIAWF 173
Cdd:cd06173 319 NTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGL------SAVFLLAGALLLLAALLLLL 382
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
23-173 |
8.49e-05 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 44.50 E-value: 8.49e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 23 DLALSAAQFGFASGVFFIGYILLEVPSNLALHRFGARRWLARIMVSWGIVALLFTWVQNFEQLVALRFLLGVAEAGFFPG 102
Cdd:cd17335 227 DLGGSKTLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAA 306
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2269430540 103 AILFLSLWVPAKHRSKILALFY-LAQPLTTVIGAPLAGFLIEQDGIlglegwRFMFLGVSLPAIVVGVIAWF 173
Cdd:cd17335 307 AVSYASAAAPPGLRATAQGLLQgLYFGLGGGLGSLIGGYLYEAFGA------RTTFRFFAIAALAGLLAFFL 372
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
55-178 |
1.56e-04 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 43.79 E-value: 1.56e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 55 RFGARRWLARIMVSWGIVALLFTWVQNFEQLVALRFLLGVAeAGFFPGAILFLSLWVPAKHRSKILALFYLAQPLTTVIG 134
Cdd:cd17391 62 RYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVF-SGYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIG 140
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 2269430540 135 APLAGFLIEQDGIlglegwRFMFLGVSLPAIVVGVIAWFYLKDK 178
Cdd:cd17391 141 PLLGGFLADLFGI------RNVFFITGGLLFLAFLLTLFFVKED 178
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
6-179 |
2.45e-04 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 42.78 E-value: 2.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 6 YLDRTAIGFAAPNgMEADLALSAAQFGFASGVFFIGYILLEVPSNLALHRFGARRWLARIMVSWGIVALLFTWVQNFEQL 85
Cdd:cd17488 16 YLTRKSFNAAMPA-MLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIINILFGFSSSLWAF 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 86 VALRFLLGVAEAGFFPGAILFLSLWVPAKHRSKILALFYLAQPLTTVIGAPLAGFLIEqdgilgLEGWRFMFLGVSLPAI 165
Cdd:cd17488 95 AVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAAL------TYGWRAGMYVPGIIAI 168
|
170
....*....|....
gi 2269430540 166 VVGVIAWFYLKDKP 179
Cdd:cd17488 169 LMGIVLCWRLRDRP 182
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
27-399 |
3.41e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 42.55 E-value: 3.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 27 SAAQFGFASGVFFIGYILLEVPSNLALHRFGARRWLARIMVSWGIVALLFTWVQNFEQLVALRFLLGVAEAGFFPGAILF 106
Cdd:cd17477 29 STALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESW 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 107 LSLWVPAKHRSKILALFYLAQPLTTVIGAPLAgflieqdGILGLEGWRFMFLGVSLPAIVVGVIAWFYLKDKPSDAkwlt 186
Cdd:cd17477 109 LNALATNENRGRVLGLYSTVLGLGFALGPLLL-------ALVGTAGALPFLIAAVLLLLALVPLLLTRRAAPEIEE---- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 187 reeqvwlttalkreedvktqgvtthpkmSTAFTSGRVWMLSFVYFG--FIYGlyalafFLPTIIEGFQEQYGTTFGIFEK 264
Cdd:cd17477 178 ----------------------------AESISLRRLLRIAPLALLgaFVAG------FLEGAFYSLLPLYGLRLGLSVA 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 265 --GLITAIPYVPAAIALYLWSRDATRRGVRTWHIVIPAIAGGLSIPLALFAGSPAATIAVITVTAMAIFSALPNFWTFPT 342
Cdd:cd17477 224 qaALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAG 303
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 2269430540 343 RFLTGAAAAAGIALINTVGNLAGFSAPYITGALRDATGGYEVPMFIVGFFLLLSAVL 399
Cdd:cd17477 304 DRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
6-231 |
5.53e-04 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 42.00 E-value: 5.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 6 YLDRTAIGFAAPNgMEADLALSAAQFGFASGVFFIGYILLEVPSNLALHRFGARRWLARIMVSWGIVALLFtwvqNFEQL 85
Cdd:PRK11663 36 YFTRKSFNAAMPE-MLADLGLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILF----GFSSS 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 86 VALRFLLGVAEAGF----FPGAILFLSLWVPAKHRSKILALFYLAQPlttvIGAPLAGFLIeqdGILGLE-GWRFMFLGV 160
Cdd:PRK11663 111 LWAFALLWVLNAFFqgwgWPVCAKLLTAWYSRTERGGWWAIWNTAHN----VGGALIPLVV---GAIALHyGWRYGMMIA 183
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2269430540 161 SLPAIVVGVIAWFYLKDKPSDAKWLTREEqvWLTTALKREEDVKTQGVTTHPKMST-AFTSGRVWMLSFVYF 231
Cdd:PRK11663 184 GIIAIVVGLFLCWRLRDKPQAMGLPSVGE--WRHDALELAQQQEGAGLSRKEILTKyVLLNPYIWLLSFSYV 253
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
55-403 |
5.69e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 41.83 E-value: 5.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 55 RFGARRWLARIMVSWGIVALLFTWVQNFEQLVALRFLLGVAEAGFFPGAILFLSLWVPAKHRSKILALFYLAQPLTTVIG 134
Cdd:cd17329 61 RFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIG 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 135 APLAGFLIEQDGilglegwRFMFLGVSLPAIVVGVIAWFYLK-DKPSDAKWLTREEQVWLTTALKReedvktqgvtthpk 213
Cdd:cd17329 141 PLLGGLLLLYSF-------RLLFLAAAVLFLLAALVLLFLLPeTRPKRRAAEKTEILRGYKIVLRD-------------- 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 214 mstaftsGRVWMLSFVYFGFIYGLYALAFFLPTIIegfQEQYGTTFGIFekGLITAIPYVPAAIALYLWSRDATRRGVRT 293
Cdd:cd17329 200 -------RAFLLFLLASFLISLIYFQLESTLPVYV---VEILGLGESLL--GLLLALNALLIVLLQFPVARLVERFRLRK 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 294 WhIVIPAIAGGLSIPLALFAGSPAATIAVITVTAMAIFSALPNFWTFPTRFLTGAAAAAGIALINTVGNLAGFSAPYITG 373
Cdd:cd17329 268 I-LMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGG 346
|
330 340 350
....*....|....*....|....*....|
gi 2269430540 374 ALRDAtGGYEVPMFIVGFFLLLSAVLMALL 403
Cdd:cd17329 347 LLLDL-LGPGLPWLILAALGLIAAALLLGL 375
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
2-171 |
9.04e-04 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 41.02 E-value: 9.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 2 FFINYLDRTAIGFAAPNgMEADLALSAAQFGFASGVFFIGYILLEVPSNLALHRFGARRWLARIMVSWGIVALLFTWVQN 81
Cdd:cd17503 5 AFMAILDTTIVNVALPT-IMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPN 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 82 FEQLVALRFLLGVAEAGFFPGAILFLSLWVPAKHRSKILALFYLAQPLTTVIGAPLAGFLIEQdgilglEGWRFMFLgVS 161
Cdd:cd17503 84 LASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDN------LSWRWIFY-IN 156
|
170
....*....|
gi 2269430540 162 LPAIVVGVIA 171
Cdd:cd17503 157 LPIGILALLL 166
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
32-177 |
1.54e-03 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 38.78 E-value: 1.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 32 GFASGVFFIGYIllevpSNLALHRFGARRWLARIMVSWGIVALLFTWVQNFEQLVALRFLLGVAEAGFFPGAILFLSLWV 111
Cdd:TIGR00880 6 GYALGQLIYSPL-----SGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2269430540 112 PAKHRSKILALFYLAQPLTTVIGAPLAGFLIEQDgilgleGWRFMFLGVSLPAIVVGVIAWFYLKD 177
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFL------GWRAPFLFLAILALAAFILLAFLLPE 140
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
12-253 |
2.51e-03 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 39.91 E-value: 2.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 12 IGFAAPNGmEADLALSAAQFGFASGVFFIGYILLEVPSNLALHRFGARRWLARIMVSWGIVALLFTWVQNFEQLVALRFL 91
Cdd:cd17438 18 VGFVLPSA-EKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYGAFLFCRLI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 92 LGVAEAGFFPGAILFLSLWVPAKHRSKILA---LFYLAQPLTTVIGA----PLAGFLIEQDGILGLEGWRFMFLGVSLPA 164
Cdd:cd17438 97 SGFGIGGSLPIVFAYFSEFLAREKRGEHLSwlcMFWMIGGLYASAMAwsiiPHYGWGFSMGTNYHFHSWRVFVIICALPC 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 165 IVvGVIAWFYLKDKPSDAKWLTREEQVWLTtaLKREEDVKTQGVTTHPKMSTAFTSGR--VWMLSFVYFGFIYGLYALAF 242
Cdd:cd17438 177 IA-SIIALKFMPESPRFLLEMGKHDEAWMI--LKNIHDTNMRAKGTPEKVFTVSNIKRknTLFLAVVWFTMAFSYYGLTV 253
|
250
....*....|.
gi 2269430540 243 FLPTIIEGFQE 253
Cdd:cd17438 254 WFPDMIRYLQK 264
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
54-340 |
2.66e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 39.89 E-value: 2.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 54 HRFGARR-WLARIMVSWGIVALLFTWVQNFEQ------LVALRFLLGVAEAGFFPGAILFLSLWVP-AKHRSKILALFYL 125
Cdd:COG2211 75 TRWGRRRpWILIGAIPLALSFVLLFTAPDLSPtgkliyALVTYLLLGLAYTLVNIPYSALGAELTPdYEERTRLSSWRFA 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 126 AQPLTTVIGAPLAGFLIEQDGILGLEGWRFMFLGVSLPAIVVGVIAWFYLKDKPSdakwltreeqvwlttalkreedVKT 205
Cdd:COG2211 155 FAGLGGLLASVLPPPLVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGTKERPV----------------------PEE 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 206 QGVTTHPKMSTAFTSGRVWMLSFVYFGFIYGLYALAFFLPTIiegFQEQYGTTFGIFekGLITAIPYVPAAIALYLWSRD 285
Cdd:COG2211 213 EKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYY---FKYVLGLSAALV--GLLLALYFLAALLGAPLWPRL 287
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 2269430540 286 ATRRGVRTWHIVIPAIAGGLSIPLALF-AGSPAATIAVITVTAMAIFSALPNFWTF 340
Cdd:COG2211 288 AKRFGKKKAFIIGLLLAALGLLLLFFLgPGNLWLLLVLAALAGIGLGAILVLPWAM 343
|
|
| MFS_SV2A |
cd17439 |
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ... |
12-264 |
2.82e-03 |
|
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340997 [Multi-domain] Cd Length: 478 Bit Score: 40.01 E-value: 2.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 12 IGFAAPNGmEADLALSAAQFGFASGVFFIGYILLEVPSNLALHRFGARRWLARIMVSWGIVALLFTWVQNFEQLVALRFL 91
Cdd:cd17439 18 VGFVLPSA-EKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 92 LGVAEAGFFPGAILFLSLWVPAKHRSKILALFYLAQPLTTVIGAPLA-------GFLIEQDGILGLEGWRFMFLGVSLPA 164
Cdd:cd17439 97 SGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGIYASAMAwaiiphyGWSFQMGSAYQFHSWRVFVLVCAFPS 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 165 iVVGVIAWFYLKDKPSDAKWLTREEQVWLTTALKREEDVKTQGvttHPKMSTAFTSGR---VWMLSFVYFGFIYGLYALA 241
Cdd:cd17439 177 -VFAIGALTTMPESPRFFLENGKHDEAWMVLKQVHDTNMRAKG---HPERVFSVTHIKrriTLMMMAVWFTMSFSYYGLT 252
|
250 260
....*....|....*....|...
gi 2269430540 242 FFLPTIIEGFQEQYGTTFGIFEK 264
Cdd:cd17439 253 VWFPDMIKHLQKSVVFEDSLFEE 275
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
26-173 |
4.65e-03 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 39.06 E-value: 4.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 26 LSAAQFGFASGVFFIGYILLEVPSNLALHRFGARRWLaRIMVSWGIVA-LLFTWVQNFEQLVALRFLLGVAEAGFFPGAI 104
Cdd:cd17372 31 LSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGL-IISALWTFYAgFLSAFAPNYMWLIILRCLVGLGLGGGPQLAS 109
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2269430540 105 LFLSlWVPAKHRSKILALFYLAQPLTTVIGAPLAGFLIEQdgilglEGWRFMFLGVSLPAIVVGVIAWF 173
Cdd:cd17372 110 WYLE-FLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPR------LGWRWLLAFSSVPSSLLLVFYRW 171
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
55-175 |
4.76e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 38.78 E-value: 4.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 55 RFGARRwlaRIMVSWGIVALLF---TWVQNFEQLVALRFLLGVAEAGFFPGAILFLSLWVPAKHRSKILALFYLAQPLTT 131
Cdd:cd17391 266 RIGHHR---ILLGALLASALLYipqAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGN 342
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 2269430540 132 VIGAPLAGFlieqdgILGLEGWRFMFLGVSLPAIVVGVIAWFYL 175
Cdd:cd17391 343 VAGPLLGSA------IAAHFGYRAVFVVTALLVLLNAIWSFIFL 380
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
27-334 |
8.14e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 38.37 E-value: 8.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 27 SAAQFGFASGVFFIGYILLEVPSNLALHRFGARRWL-----ARIMVSWGIVALLFTWVQNFEQLVALRFLLGVAEAGFFP 101
Cdd:cd06173 32 SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLiladlLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGP 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 102 GAILFLSLWVPAKHRSKILALFYLAQPLTTVIGAPLAGFLIEQDGIlgleGWRFMFLGVSLPAIVVGVIAWFYLKDKPSD 181
Cdd:cd06173 112 ARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGP----GGAFAINALSFLLSALLLLFIRRPPPAAPG 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 182 AKWLTREEQVWLTTALKREedvktqgvttHPKMSTAFTSGRVWMLSFVYFGFIYGLYALafflpTIIEGFQEQYGTTFGI 261
Cdd:cd06173 188 ESSSLLLRDLREGLRYLRR----------SPLLRLLLLALALFALLGGALTVLLPLLAK-----EVLGGGAAGYGLLLAA 252
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2269430540 262 FEKGLITAipyvpAAIAlylwsrdATRRGVRTWHIVIPAIAGGLSIPLALFAGSPAATIAVITVTAMAIFSAL 334
Cdd:cd06173 253 FGVGALLG-----ALLL-------GRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGL 313
|
|
| MFS_4 |
pfam06779 |
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane ... |
19-400 |
9.52e-03 |
|
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane proteins which may be sugar transporters. Members carry twelve transmembrane regions which are characteriztic of members of the major facilitator sugar-transporter superfamily.
Pssm-ID: 399632 [Multi-domain] Cd Length: 365 Bit Score: 38.12 E-value: 9.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 19 GMEADLALSAAQFGFASGVFFIGYILLEVPSNLALHRFGAR-RWLARIMVsWGIVALLFT--WVQNFEQLVALRFLLGVA 95
Cdd:pfam06779 18 VMIAEGQFSLSQAGLLAAANYAGYLAGALLASFAWRHGASRlRPALLAGL-LATVLLLLAmaATSSFWAVLLIRFLAGVA 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 96 EAG-FFPGAILFLSLWVPAKHRSkILALFYLAQPLTTVIGAPLAGFLIEQDGilgleGWRFMFLGVSLPAIVVGVIAWFY 174
Cdd:pfam06779 97 SAAvMIFGSSLILGHATAARRAF-VGALLFAGVGIGIALSGLLVPLGLQLGL-----GGSSLWYGAGVLSAVLTLAVFPL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 175 LKDKPSdakwltreeqvwlttalkreedvkTQGVTTHPKMSTAFTSGRVWMLSFVYFGFIYGLYALAFFLPTII-EGFQe 253
Cdd:pfam06779 171 LPRRAP------------------------RHASAPAPAAKPLQRSLPLWILTLAYGLAGFGYIITATFLPAMArDGFG- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 254 qygttfGIFEKGLITAIPYVPAAIALYLWSRDATRRGVRTWHIVIPAI-AGGLSIPLALFA-GSPAATIAVITVTAMAIF 331
Cdd:pfam06779 226 ------GPAAAALFWSLFGLAAALGVLVWLRAAKRWGTRPALTAALLIqALGVLLSLLSPSpAGLAVSSLLFGGTFMAIT 299
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2269430540 332 SALPNFwtfpTRFLTGAAAAAGIALINTVGNLAGFSAPYITGALRDATGGYEVPMFIVGFFLLLSAVLM 400
Cdd:pfam06779 300 SLVMQL----ARELAPPAPRRLLGLMTASFGIGQILGPLLASLLTAATGGLTPALLLAAAALVLAALIV 364
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
20-330 |
9.57e-03 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 37.94 E-value: 9.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 20 MEADLALSAAQFGFASGVFFIGYILLEVPSNLALHRFGaRRWLARIMVSWGIVALLFTW-VQNFEQLVALRFL--LGVAE 96
Cdd:cd17320 25 IARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFG-RRPVLLAGLLLFILASLLCAlASSIEQLLIARFLqgLGAAA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 97 AGFFPGAILFLSLwvPAKHRSKILALFYLAQPLTTVIgAPLAGFLieqdgILGLEGWRFMFLGVSLPAIVVGVIAWFYLK 176
Cdd:cd17320 104 GSVVARAIVRDLY--SGAELAKIFSLLMMILAIAPAL-APLLGGL-----LLLFFGWRAIFVFLALLGLLLLLLVLLFLP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2269430540 177 DKPSDAKWLTREEQVWLTtalkreedvktqgvtthpkMSTAFTSGRVWMLSFVYFGFIYGLYALAFFLPTIiegFQEQYG 256
Cdd:cd17320 176 ETLPEEKRKPLLSSLLRA-------------------YKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFI---YIEQLG 233
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2269430540 257 TTFGIFekGLITAIPYVPAAIALYLWSRDATRRGVRT--WHIVIPAIAGGLSIPLALFAGSPAATIAVITVTAMAI 330
Cdd:cd17320 234 LSPAQF--GLLFALNAIALILGSLLNGRLVRRFGPRRllRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFF 307
|
|
| |
