|
Name |
Accession |
Description |
Interval |
E-value |
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
6-519 |
2.70e-164 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 475.41 E-value: 2.70e-164
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 6 FRSGMIVSAMTMISRILGLVRDAVVANLLGAGAAADVFLFANRIPNFLRRLFAEGAFAQAFVPVLSEIKQQQGDEKVRIF 85
Cdd:COG0728 1 LRAALIVAIGTLLSRILGFVRDILIAAAFGAGAVADAFFVAFRIPNLLRRLFAEGALSAAFVPVLAEALEKEGEEEARRF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 86 VAQAAGTLGTILLIVTLFGVIASPVIAALFGTGWfidwwqggpDAEKFELASSLLKLTFPYLFFVSLVALSGAVMNVYNR 165
Cdd:COG0728 81 ASRVLTLLLLVLLVLTLLGILFAPLLVKLLAPGF---------DPEKFALAVALTRIMFPYILFIGLSALLGGVLNARGR 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 166 FAVAAFTPVLLNVSIIGCAILLHDQFSVGAYALAIGVFLGGVVQLLFQLPFLYKAKMLARPRWGWQDENVKKVRKLMLPA 245
Cdd:COG0728 152 FAAPALAPVLLNLVIIAGLLLLAPLFGPGIYALAWGVLLGGVLQLLIQLPALRRLGLRLRPRFDLRDPGVRRVLKLMLPA 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 246 LFGVSISQINLLLDTVIASLLMTGSIAWLYYSDRLIEFPLGLFGIGIATVILPALSKLHSSKKSSDFQHTLDWGVRFVIF 325
Cdd:COG0728 232 LLGVSVSQINLLVDTILASFLPEGSVSALYYADRLYQLPLGLFGVAIGTALLPRLSRAAAAGDLEEFRRTLSRGLRLVLL 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 326 LGLPAMIGLMIISPLIITVLFDHGAFkeaGIDHVKAVSLGVVAYSVGLVSFMLIKVLAPGFYSRQDTKTPVRIGIVTLVL 405
Cdd:COG0728 312 LTLPAAVGLIVLAEPIVRLLFERGAF---TAEDTALTALALAAYALGLPAFALVKVLARAFYARQDTRTPVRIAVIAVVV 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 406 NMVFNIMLAPFIGYLGLALATSMSASCNAYLLYRQLKKENVYQFSSMSGYFTLKCLLASITMGALVWFTSRQY-DWVSWH 484
Cdd:COG0728 389 NIVLNLLLVPPLGHAGLALATSLSALVNALLLLVLLRRRLGGLPLRGILRTLLKLLLASLVMGAVLWLLLRLLgDWLGGG 468
|
490 500 510
....*....|....*....|....*....|....*
gi 2278028608 485 FSEQVMLLVVLLIIAIVSYFFMLFLMGVRLNTIKS 519
Cdd:COG0728 469 LLGRLLALALLILVGAAVYFALLLLLGVRLRDLLR 503
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
13-443 |
3.37e-142 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 416.08 E-value: 3.37e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 13 SAMTMISRILGLVRDAVVANLLGAGAAADVFLFANRIPNFLRRLFAEGAFAQAFVPVLSEIKQQQGDEKVRIFVAQAAGT 92
Cdd:cd13123 1 AIGTLLSRILGFVRDVLIAAAFGAGPLADAFFVAFRIPNLLRRLFAEGALSAAFVPVFSEYLEKEGEEEARRFASRVLTL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 93 LGTILLIVTLFGVIASPVIAALFGTGWfidwwqggpDAEKFELASSLLKLTFPYLFFVSLVALSGAVMNVYNRFAVAAFT 172
Cdd:cd13123 81 LLLVLLLLTLLGILFAPLLVKLLAPGF---------SGDKFELAVALTRIMFPYLLFISLSALLGGILNAHGRFFAPALA 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 173 PVLLNVSIIGCAILLHDQFSVGAYALAIGVFLGGVVQLLFQLPFLYKAKMLARPRWGWQDENVKKVRKLMLPALFGVSIS 252
Cdd:cd13123 152 PVLLNLVIIAGLLLLAPLFDLGIYALAWGVLLGGVLQLLVQLPALRRLGFRFRPRLDFRDPGVRRVLKLMLPALLGVSVS 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 253 QINLLLDTVIASLLMTGSIAWLYYSDRLIEFPLGLFGIGIATVILPALSKLHSSKKSSDFQHTLDWGVRFVIFLGLPAMI 332
Cdd:cd13123 232 QINLLVDTILASFLPEGSISALYYADRLYQLPLGIFGVAIATALLPRLSRLAAAGDLDEFRRTLSRGLRLVLFLLLPAAV 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 333 GLMIISPLIITVLFDHGAFkeaGIDHVKAVSLGVVAYSVGLVSFMLIKVLAPGFYSRQDTKTPVRIGIVTLVLNMVFNIM 412
Cdd:cd13123 312 GLIVLAEPIVRLLFERGAF---TAEDTLMTASALAAYALGLPAFALVKLLSRAFYALKDTKTPVKIAVIAVAVNILLNLL 388
|
410 420 430
....*....|....*....|....*....|.
gi 2278028608 413 LAPFIGYLGLALATSMSASCNAYLLYRQLKK 443
Cdd:cd13123 389 LIKPLGHVGLALATSLSAWVNALLLLVLLRR 419
|
|
| MurJ |
pfam03023 |
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of ... |
41-475 |
1.72e-111 |
|
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of peptidoglycan precursor lipid II (undecaprenyl-pyrophosphate-linked N-acetyl glucosamine-N-acetyl muramic acid-pentapeptide) on the cytosolic face of the cell membrane. Lipid II is then translocated across the membrane and its glycopeptide moiety becomes incorporated into the growing cell wall mesh. MviN, renamed as MurJ, is a lipid II flippase essential for cell wall peptidoglycan synthesis. MurJ belongs to the MVF (mouse virulence factor) family of MOP superfamily transporters, which also includes the MATE (multidrug and toxic compound extrusion) transporter and eukaryotic OLF (oligosaccharidyl-lipid flippase) families. In addition to the canonical MOP transporter core consisting of 12 transmembrane helices (TMs), MurJ has two additional C-terminal TMs (13 and 14) of unknown function. Structural analysis indicates that the N lobe (TMs 1-6) and C lobe (TMs 7-14) are arranged in an inward-facing N-shape conformation, rather than the outward-facing V-shape conformation observed in all existing MATE transporter structures. Furthermore, a hydrophobic groove is formed by two C-terminal transmembrane helices, which leads into a large central cavity that is mostly cationic. Mutagenesis studies, revealed a solvent-exposed cavity that is essential for function. Mutation of conserved residues (Ser17, Arg18, Arg24, Arg52, and Arg255) at the proximal site failed to complement MurJ function, consistent with the idea that these residues are important for recognizing the diphosphate and/or sugar moieties of lipid II. It has also been suggested that the chloride ion in the central cavity and a zinc ion at the beginning of TM 7 might be functionally important.
Pssm-ID: 397249 [Multi-domain] Cd Length: 451 Bit Score: 338.50 E-value: 1.72e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 41 DVFLFANRIPNFLRRLFAEGAFAQAFVPVLSEIKQQQGDEKvRIFVAQAAGTLGTILLIVTLFGVIASPVIAALFGTGWf 120
Cdd:pfam03023 12 DAFNVAFKIPNLLRRLFAEGAFSSAFIPVLAELKAQDKEEA-AEFVRKVSTLLILVLLLVTLIGILAAPWLIRLLAPGF- 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 121 idwwqggpDAEKFELASSLLKLTFPYLFFVSLVALSGAVMNVYNRFAVAAFTPVLLNVSIIGCAILLHDQFSVGAYALAI 200
Cdd:pfam03023 90 --------DPETFSLAVSLLRITFPYLLLVSLSAVFGAVLNARKKFFAPSFSPVLLNVGVILTLLLLANYLGNAIYALAI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 201 GVFLGGVVQLLFQLPFLYKAKMLARPRWGWQDENVKKVRKLMLPALFGVSISQINLLLDTVIASLLMTGSIAWLYYSDRL 280
Cdd:pfam03023 162 GVLIGGVLQLLVQLPFLKKAGLLLKPRFGFRDKGLKRFLKLMLPTLLGVSVSQLNLLIDTFLASFLAPGSVSYLYYADRI 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 281 IEFPLGLFGIGIATVILPALSKLHSSKKSSDFQHTLDWGVRFVIFLGLPAMIGLMIISPLIITVLFDHGAFkeaGIDHVK 360
Cdd:pfam03023 242 YQLPLGIFGVSISTVLLPRLSRHAADGDWDEFRDLLDQAIRLTLLLMIPVSFGLLVLSIPIVSLLFERGNF---SPEDVT 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 361 AVSLGVVAYSVGLVSFMLIKVLAPGFYSRQDTKTPVRIGIVTLVLNMVFNIMLAPFIGYLGLALATSMSASCNAYLLYRQ 440
Cdd:pfam03023 319 ATAEVLAAYALGLIPYALVKLLSRVFYAREDTKTPFKISLISAVLNILLSLLLLPPLGVAGLALATSLSSLIGLVFLYYI 398
|
410 420 430
....*....|....*....|....*....|....*
gi 2278028608 441 LKKENVYQFSSMSGYFTLKCLLASITMGALVWFTS 475
Cdd:pfam03023 399 LRKRLGGFDLRGIKTFLASLVVPTALMAGVILLLS 433
|
|
| murJ_mviN |
TIGR01695 |
murein biosynthesis integral membrane protein MurJ; This model represents MurJ (previously ... |
4-512 |
7.80e-101 |
|
murein biosynthesis integral membrane protein MurJ; This model represents MurJ (previously MviN), a family of integral membrane proteins predicted to have ten or more transmembrane regions. Members have been suggested to act as a lipid II flippase, translocated a precursor of murein. However, it appears FtsW has that activity. Flippase activity for MurJ has not been shown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273763 [Multi-domain] Cd Length: 502 Bit Score: 312.72 E-value: 7.80e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 4 GLFRSGMIVSAMTMISRILGLVRDAVVANLLGAGAAADVFLFANRIPNFLRRLFAEGAFAQAFVPVLSEIKQQQGDEKvR 83
Cdd:TIGR01695 1 SLLKSTLIVSLGTLFSRITGFVRDAIIASAFGAGLTADAFNVAFVIPNFFRRLFAEGAFNSAFVPVFTKAKKKEKEAR-R 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 84 IFVAQAAGTLGTILLIVTLFGVIASPVIAALFGTGWfidwwqggpDAEKFELASSLLKLTFPYLFFVSLVALSGAVMNVY 163
Cdd:TIGR01695 80 AFANTVTTLLILSLLLVVLIGIFFAPFVISLLAPGF---------ADETRSLAVSLTRIMFPYLLLISLAAVFGGILNAR 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 164 NRFAVAAFTPVLLNVSIIGCAILLHDQFSVGAYALAIGVFLGGVVQLLFQLPFLYKAKMLARPRWGWQDENVKKVRKLML 243
Cdd:TIGR01695 151 KRFFIPSFSPILFNIGVILSLLFFDWNYGQYSLALAIGVLIGGVAQLLIQLPFLRKAGFLLKPRFNFRDPGLKRFLKLFL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 244 PALFGVSISQINLLLDTVIASLLMTGSIAWLYYSDRLIEFPLGLFGIGIATVILPALSKLHSSKKSSDFQHTLDWGVRFV 323
Cdd:TIGR01695 231 PTTLGSSASQITLLINTALASFLEIGSVSALYYANRIYQLPLGIFGISLSTVLLPKLSRHASEGNWNELRDLLNQGIRLS 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 324 IFLGLPAMIGLMIISPLIITVLFDHGAFkeaGIDHVKAVSLGVVAYSVGLVSFMLIKVLAPGFYSRQDTKTPVRIGIVTL 403
Cdd:TIGR01695 311 LLLTIPSSFGLLILSIPIVSLLFERGAF---SEEDTVMTATILAAYGLGLIFYSLQKVLLRAFYARKDTRTPFINSVISV 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 404 VLNMVFNIMLAPFIGYLGLALATSMSASCNAYLLYRQLKKENVYQFSSMSGYFTLKCLLASITMGALVWFTSRQYDWVSw 483
Cdd:TIGR01695 388 VLNALLSLLLIFPLGLVGIALATSAASMVSSVLLYLMLNRRLKGILPFGVLKVLAKLVIASAIIGGVLYLIVSVSLGGV- 466
|
490 500
....*....|....*....|....*....
gi 2278028608 484 hFSEQVMLLVVLLIIAIVSYFFMLFLMGV 512
Cdd:TIGR01695 467 -LVKNLLGLLAIGLIGLLVYFLGLALLKI 494
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
6-519 |
2.70e-164 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 475.41 E-value: 2.70e-164
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 6 FRSGMIVSAMTMISRILGLVRDAVVANLLGAGAAADVFLFANRIPNFLRRLFAEGAFAQAFVPVLSEIKQQQGDEKVRIF 85
Cdd:COG0728 1 LRAALIVAIGTLLSRILGFVRDILIAAAFGAGAVADAFFVAFRIPNLLRRLFAEGALSAAFVPVLAEALEKEGEEEARRF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 86 VAQAAGTLGTILLIVTLFGVIASPVIAALFGTGWfidwwqggpDAEKFELASSLLKLTFPYLFFVSLVALSGAVMNVYNR 165
Cdd:COG0728 81 ASRVLTLLLLVLLVLTLLGILFAPLLVKLLAPGF---------DPEKFALAVALTRIMFPYILFIGLSALLGGVLNARGR 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 166 FAVAAFTPVLLNVSIIGCAILLHDQFSVGAYALAIGVFLGGVVQLLFQLPFLYKAKMLARPRWGWQDENVKKVRKLMLPA 245
Cdd:COG0728 152 FAAPALAPVLLNLVIIAGLLLLAPLFGPGIYALAWGVLLGGVLQLLIQLPALRRLGLRLRPRFDLRDPGVRRVLKLMLPA 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 246 LFGVSISQINLLLDTVIASLLMTGSIAWLYYSDRLIEFPLGLFGIGIATVILPALSKLHSSKKSSDFQHTLDWGVRFVIF 325
Cdd:COG0728 232 LLGVSVSQINLLVDTILASFLPEGSVSALYYADRLYQLPLGLFGVAIGTALLPRLSRAAAAGDLEEFRRTLSRGLRLVLL 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 326 LGLPAMIGLMIISPLIITVLFDHGAFkeaGIDHVKAVSLGVVAYSVGLVSFMLIKVLAPGFYSRQDTKTPVRIGIVTLVL 405
Cdd:COG0728 312 LTLPAAVGLIVLAEPIVRLLFERGAF---TAEDTALTALALAAYALGLPAFALVKVLARAFYARQDTRTPVRIAVIAVVV 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 406 NMVFNIMLAPFIGYLGLALATSMSASCNAYLLYRQLKKENVYQFSSMSGYFTLKCLLASITMGALVWFTSRQY-DWVSWH 484
Cdd:COG0728 389 NIVLNLLLVPPLGHAGLALATSLSALVNALLLLVLLRRRLGGLPLRGILRTLLKLLLASLVMGAVLWLLLRLLgDWLGGG 468
|
490 500 510
....*....|....*....|....*....|....*
gi 2278028608 485 FSEQVMLLVVLLIIAIVSYFFMLFLMGVRLNTIKS 519
Cdd:COG0728 469 LLGRLLALALLILVGAAVYFALLLLLGVRLRDLLR 503
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
13-443 |
3.37e-142 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 416.08 E-value: 3.37e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 13 SAMTMISRILGLVRDAVVANLLGAGAAADVFLFANRIPNFLRRLFAEGAFAQAFVPVLSEIKQQQGDEKVRIFVAQAAGT 92
Cdd:cd13123 1 AIGTLLSRILGFVRDVLIAAAFGAGPLADAFFVAFRIPNLLRRLFAEGALSAAFVPVFSEYLEKEGEEEARRFASRVLTL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 93 LGTILLIVTLFGVIASPVIAALFGTGWfidwwqggpDAEKFELASSLLKLTFPYLFFVSLVALSGAVMNVYNRFAVAAFT 172
Cdd:cd13123 81 LLLVLLLLTLLGILFAPLLVKLLAPGF---------SGDKFELAVALTRIMFPYLLFISLSALLGGILNAHGRFFAPALA 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 173 PVLLNVSIIGCAILLHDQFSVGAYALAIGVFLGGVVQLLFQLPFLYKAKMLARPRWGWQDENVKKVRKLMLPALFGVSIS 252
Cdd:cd13123 152 PVLLNLVIIAGLLLLAPLFDLGIYALAWGVLLGGVLQLLVQLPALRRLGFRFRPRLDFRDPGVRRVLKLMLPALLGVSVS 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 253 QINLLLDTVIASLLMTGSIAWLYYSDRLIEFPLGLFGIGIATVILPALSKLHSSKKSSDFQHTLDWGVRFVIFLGLPAMI 332
Cdd:cd13123 232 QINLLVDTILASFLPEGSISALYYADRLYQLPLGIFGVAIATALLPRLSRLAAAGDLDEFRRTLSRGLRLVLFLLLPAAV 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 333 GLMIISPLIITVLFDHGAFkeaGIDHVKAVSLGVVAYSVGLVSFMLIKVLAPGFYSRQDTKTPVRIGIVTLVLNMVFNIM 412
Cdd:cd13123 312 GLIVLAEPIVRLLFERGAF---TAEDTLMTASALAAYALGLPAFALVKLLSRAFYALKDTKTPVKIAVIAVAVNILLNLL 388
|
410 420 430
....*....|....*....|....*....|.
gi 2278028608 413 LAPFIGYLGLALATSMSASCNAYLLYRQLKK 443
Cdd:cd13123 389 LIKPLGHVGLALATSLSAWVNALLLLVLLRR 419
|
|
| MurJ |
pfam03023 |
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of ... |
41-475 |
1.72e-111 |
|
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of peptidoglycan precursor lipid II (undecaprenyl-pyrophosphate-linked N-acetyl glucosamine-N-acetyl muramic acid-pentapeptide) on the cytosolic face of the cell membrane. Lipid II is then translocated across the membrane and its glycopeptide moiety becomes incorporated into the growing cell wall mesh. MviN, renamed as MurJ, is a lipid II flippase essential for cell wall peptidoglycan synthesis. MurJ belongs to the MVF (mouse virulence factor) family of MOP superfamily transporters, which also includes the MATE (multidrug and toxic compound extrusion) transporter and eukaryotic OLF (oligosaccharidyl-lipid flippase) families. In addition to the canonical MOP transporter core consisting of 12 transmembrane helices (TMs), MurJ has two additional C-terminal TMs (13 and 14) of unknown function. Structural analysis indicates that the N lobe (TMs 1-6) and C lobe (TMs 7-14) are arranged in an inward-facing N-shape conformation, rather than the outward-facing V-shape conformation observed in all existing MATE transporter structures. Furthermore, a hydrophobic groove is formed by two C-terminal transmembrane helices, which leads into a large central cavity that is mostly cationic. Mutagenesis studies, revealed a solvent-exposed cavity that is essential for function. Mutation of conserved residues (Ser17, Arg18, Arg24, Arg52, and Arg255) at the proximal site failed to complement MurJ function, consistent with the idea that these residues are important for recognizing the diphosphate and/or sugar moieties of lipid II. It has also been suggested that the chloride ion in the central cavity and a zinc ion at the beginning of TM 7 might be functionally important.
Pssm-ID: 397249 [Multi-domain] Cd Length: 451 Bit Score: 338.50 E-value: 1.72e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 41 DVFLFANRIPNFLRRLFAEGAFAQAFVPVLSEIKQQQGDEKvRIFVAQAAGTLGTILLIVTLFGVIASPVIAALFGTGWf 120
Cdd:pfam03023 12 DAFNVAFKIPNLLRRLFAEGAFSSAFIPVLAELKAQDKEEA-AEFVRKVSTLLILVLLLVTLIGILAAPWLIRLLAPGF- 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 121 idwwqggpDAEKFELASSLLKLTFPYLFFVSLVALSGAVMNVYNRFAVAAFTPVLLNVSIIGCAILLHDQFSVGAYALAI 200
Cdd:pfam03023 90 --------DPETFSLAVSLLRITFPYLLLVSLSAVFGAVLNARKKFFAPSFSPVLLNVGVILTLLLLANYLGNAIYALAI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 201 GVFLGGVVQLLFQLPFLYKAKMLARPRWGWQDENVKKVRKLMLPALFGVSISQINLLLDTVIASLLMTGSIAWLYYSDRL 280
Cdd:pfam03023 162 GVLIGGVLQLLVQLPFLKKAGLLLKPRFGFRDKGLKRFLKLMLPTLLGVSVSQLNLLIDTFLASFLAPGSVSYLYYADRI 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 281 IEFPLGLFGIGIATVILPALSKLHSSKKSSDFQHTLDWGVRFVIFLGLPAMIGLMIISPLIITVLFDHGAFkeaGIDHVK 360
Cdd:pfam03023 242 YQLPLGIFGVSISTVLLPRLSRHAADGDWDEFRDLLDQAIRLTLLLMIPVSFGLLVLSIPIVSLLFERGNF---SPEDVT 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 361 AVSLGVVAYSVGLVSFMLIKVLAPGFYSRQDTKTPVRIGIVTLVLNMVFNIMLAPFIGYLGLALATSMSASCNAYLLYRQ 440
Cdd:pfam03023 319 ATAEVLAAYALGLIPYALVKLLSRVFYAREDTKTPFKISLISAVLNILLSLLLLPPLGVAGLALATSLSSLIGLVFLYYI 398
|
410 420 430
....*....|....*....|....*....|....*
gi 2278028608 441 LKKENVYQFSSMSGYFTLKCLLASITMGALVWFTS 475
Cdd:pfam03023 399 LRKRLGGFDLRGIKTFLASLVVPTALMAGVILLLS 433
|
|
| murJ_mviN |
TIGR01695 |
murein biosynthesis integral membrane protein MurJ; This model represents MurJ (previously ... |
4-512 |
7.80e-101 |
|
murein biosynthesis integral membrane protein MurJ; This model represents MurJ (previously MviN), a family of integral membrane proteins predicted to have ten or more transmembrane regions. Members have been suggested to act as a lipid II flippase, translocated a precursor of murein. However, it appears FtsW has that activity. Flippase activity for MurJ has not been shown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273763 [Multi-domain] Cd Length: 502 Bit Score: 312.72 E-value: 7.80e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 4 GLFRSGMIVSAMTMISRILGLVRDAVVANLLGAGAAADVFLFANRIPNFLRRLFAEGAFAQAFVPVLSEIKQQQGDEKvR 83
Cdd:TIGR01695 1 SLLKSTLIVSLGTLFSRITGFVRDAIIASAFGAGLTADAFNVAFVIPNFFRRLFAEGAFNSAFVPVFTKAKKKEKEAR-R 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 84 IFVAQAAGTLGTILLIVTLFGVIASPVIAALFGTGWfidwwqggpDAEKFELASSLLKLTFPYLFFVSLVALSGAVMNVY 163
Cdd:TIGR01695 80 AFANTVTTLLILSLLLVVLIGIFFAPFVISLLAPGF---------ADETRSLAVSLTRIMFPYLLLISLAAVFGGILNAR 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 164 NRFAVAAFTPVLLNVSIIGCAILLHDQFSVGAYALAIGVFLGGVVQLLFQLPFLYKAKMLARPRWGWQDENVKKVRKLML 243
Cdd:TIGR01695 151 KRFFIPSFSPILFNIGVILSLLFFDWNYGQYSLALAIGVLIGGVAQLLIQLPFLRKAGFLLKPRFNFRDPGLKRFLKLFL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 244 PALFGVSISQINLLLDTVIASLLMTGSIAWLYYSDRLIEFPLGLFGIGIATVILPALSKLHSSKKSSDFQHTLDWGVRFV 323
Cdd:TIGR01695 231 PTTLGSSASQITLLINTALASFLEIGSVSALYYANRIYQLPLGIFGISLSTVLLPKLSRHASEGNWNELRDLLNQGIRLS 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 324 IFLGLPAMIGLMIISPLIITVLFDHGAFkeaGIDHVKAVSLGVVAYSVGLVSFMLIKVLAPGFYSRQDTKTPVRIGIVTL 403
Cdd:TIGR01695 311 LLLTIPSSFGLLILSIPIVSLLFERGAF---SEEDTVMTATILAAYGLGLIFYSLQKVLLRAFYARKDTRTPFINSVISV 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 404 VLNMVFNIMLAPFIGYLGLALATSMSASCNAYLLYRQLKKENVYQFSSMSGYFTLKCLLASITMGALVWFTSRQYDWVSw 483
Cdd:TIGR01695 388 VLNALLSLLLIFPLGLVGIALATSAASMVSSVLLYLMLNRRLKGILPFGVLKVLAKLVIASAIIGGVLYLIVSVSLGGV- 466
|
490 500
....*....|....*....|....*....
gi 2278028608 484 hFSEQVMLLVVLLIIAIVSYFFMLFLMGV 512
Cdd:TIGR01695 467 -LVKNLLGLLAIGLIGLLVYFLGLALLKI 494
|
|
| SpoVB |
COG5841 |
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle ... |
95-512 |
8.05e-18 |
|
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 444543 [Multi-domain] Cd Length: 532 Bit Score: 86.37 E-value: 8.05e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 95 TILLIVTLFGVIASPVIaaLFGTGWFIDWWQGGPDAekfelASSLLKLTFPYLFFVSLVALSG-----AVMNVYnrfAVA 169
Cdd:COG5841 87 VSLLLLLILGLVFFLLL--FFGAPFIARLLLGDPRA-----YYSLRALAPALLIVPVMSVLRGyfqglQNMTPT---AVS 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 170 AFTPVLLNVSII--GCAILLHDQFSVGAYALAIGVFLGGVVQLLFqLPFLYKAKMLARPRWGWQDENVKKVR-------- 239
Cdd:COG5841 157 QVIEQIVRVIFIllLAYLLLPYGLEYAAAGATFGAVIGALAGLLV-LLYYYRKRKKKLKRLLEKSKTKSKESskdilkel 235
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 240 -KLMLPALFGVSISQINLLLD--TVIASLLMTG-----SIAWL-YYSDR---LIEFPLgLFGIGIATVILPALSKLHSSK 307
Cdd:COG5841 236 lRIAIPITLSSLVLPLFQLIDsfTVPRRLQAAGlsaseATSLYgILSGMaqpLVNLPT-VLATALATSLVPAISEAFAKK 314
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 308 KSSDFQHTLDWGVRFVIFLGLPAMIGLMIISPLIITVLFdhgafkeagidHVKAVSLGVVAYSVGLVSFMLIKVLAPGFY 387
Cdd:COG5841 315 DRKLVRRRINQALRLTLLIGLPAAVGLAVLAEPINTLLF-----------GNPEGGGILAILAPSAIFLSLQQVTTGILQ 383
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 388 SRQDTKTPVRIGIVTLVLNMVFNIMLAPFIGYLGLALATSMSASCNAYLLYRQLKKenVYQFSSMSGYFTLKCLLASITM 467
Cdd:COG5841 384 GLGKQKIPVINLLIGLLVKIILNYLLVPLFGIYGAALATVIGYLVAAILNLAALKK--YTGFKLDLRRRLLKPLLASLIM 461
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 2278028608 468 GALVWFTSRQ-YDWVSWHFSEQVMLLVVLLIIAIVSYFFMLFLMGV 512
Cdd:COG5841 462 GIVVLLLYRLlSLFLPESRLGALLATLIAVLVGAIVYLLLLLKLGL 507
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
93-442 |
8.49e-14 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 72.96 E-value: 8.49e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 93 LGTILLIVTLFGVIASPVIAALFGTGWFIDWwqggpdaekfeLASSLLKLTFPYLFFVSLVALSGAVMNVYNRFAVAAFT 172
Cdd:cd13128 76 ISTSLVLKLILGILALLLLFLFAFLIAFYDP-----------ELVLLLYILALSLPFSALNSLFRGIFQGFEKMKYIVIA 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 173 PVLLNVS-IIGCAILLHdqFSVGAYALAIGVFLGGVVQLLFQLpFLYKAKMLARPRWGWQDENVKKVRKLMLPALFGVSI 251
Cdd:cd13128 145 RIIESVLsLILALILVL--LGGGLIGFALAYLIASVLSAILLL-YIYRKKILLPKFFSFDLKLAKELLRFSIPLALSGIF 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 252 SQINLLLDTVIASLLMTGSIAWLY-YSDRLIEFpLGLFGIGIATVILPALSKLHSSKKSsDFQHTLDWGVRFVIFLGLPA 330
Cdd:cd13128 222 SLIYTRIDTIMLGYFLGDAAVGIYnAAYRIAEL-LLFIPSAISTALFPRISELYKNDKD-ELKKLLKKSFKYLFLISLPI 299
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 331 MIGLMIISPLIITVLFdhGAFKEAGIDHVKAVSLGVVAYSVGLVSFMLikvlapgFYSRQDTKTPVRIGIVTLVLNMVFN 410
Cdd:cd13128 300 AIGLFLFAEPIITLLF--GEEYLPAALVLQILAWGFLFIFLNGIFGSI-------LQAIGKQKLTLKILLIGALLNVILN 370
|
330 340 350
....*....|....*....|....*....|..
gi 2278028608 411 IMLAPFIGYLGLALATSMSASCNAYLLYRQLK 442
Cdd:cd13128 371 LLLIPKYGIIGAAIATLISEFIIFILLLYLLK 402
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
97-444 |
1.52e-10 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 63.26 E-value: 1.52e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 97 LLIVTLFGVIASpvIAALFGTGWFIDWWQGGPDAekfelASSLLKLTFPYLFFVSLVALSGAV--MNVYNRFAVAAFTPV 174
Cdd:cd13124 79 LILLLILGLVFF--LLLFFGAPFLAQLLLGDPRL-----APVIRALAPAILIVPLLSVLRGYFqgLQNMTPTAVSQVIEQ 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 175 LLNVSII--GCAILLHDQFSV--GAYALAIGVFLGGVVQLLFQLPFLYKAKMLARPRWGWQDENVKKVRKLM-------L 243
Cdd:cd13124 152 IVRVIVIlvLAYLLLPVGGGLyyAAAGATFGAVIGALAGLLVLLYYYRKKRRELKRLLRKSPRSKISTKEILkellsyaI 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 244 PALFGVSISQINLLLD--TVIASLLMTG------SIAWLYYSDR---LIEFPLgLFGIGIATVILPALSKLHSSKKSSDF 312
Cdd:cd13124 232 PITLSSLILPLLQLIDsfTVPRRLQAAGlseseaTALYGILTGRaqpLVQLPT-VIATALSTSLVPAISEAYAKGDKKEL 310
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 313 QHTLDWGVRFVIFLGLPAMIGLMIISPLIITVLFdhgafkeagidHVKAVSLGVVAYSVGLVSFMLIKVLAPGFYSRQDT 392
Cdd:cd13124 311 RRRINQALRLTLLIGLPAAVGLAVLAEPINTLLF-----------GDSEGGLILQILAPSILFLSLQQVTAAILQGLGKV 379
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 2278028608 393 KTPVRIGIVTLVLNMVFNIMLAPFIGYLGLALATSMSASCNAYLLYRQLKKE 444
Cdd:cd13124 380 KIPVINLLIGLLVKIVLNYVLIPIFGIYGAAIATVIGFLVAALLNLRALKKL 431
|
|
| Polysacc_synt_C |
pfam14667 |
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral ... |
367-512 |
5.12e-07 |
|
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral membrane region of polysaccharide biosynthesis proteins.
Pssm-ID: 434111 [Multi-domain] Cd Length: 141 Bit Score: 49.11 E-value: 5.12e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 367 VAYSVGLVSFMLIKVLAPGFYSRQDTKTPVRIGIVTLVLNMVFNIMLAPFIGYLGLALATSMSASCNAYLLYRQLKKENV 446
Cdd:pfam14667 3 QILALSIIFLSLSTVLTSILQGLGRTKLALIALLIGALVKLILNLLLIPLFGIVGAAIATVISLLVVALLNLYYLRRYLG 82
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2278028608 447 YQFSSMSgyfTLKCLLASITMGALVWFTSrqydWVSWHFSEQVMLLVVLLIIAIVSYFFMLFLMGV 512
Cdd:pfam14667 83 LRLLLRR---LLKPLLAALVMGIVVYLLL----LLLGLLLGLALALLLAVLVGALVYLLLLLLLKL 141
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
88-438 |
5.17e-06 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 48.79 E-value: 5.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 88 QAAGTLGTILLIVTLFGVIASPVIAALFgtgWFIDWWQGGPDAekfelaSSLLKLTFPYLFFVSLVALSGAVMNVYNRFA 167
Cdd:COG2244 74 ELRRLLSTALLLRLLLSLLLALLLLLLA---PFIAALLGEPEL------ALLLLLLALALLLSALSAVLLALLRGLERFK 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 168 VAAFTPVLLNVSIIGCAILLhdqfsvgayalaigVFLGGVVQLLfqlpflykakmlarprwgwqdenvkkVRKLMLPALF 247
Cdd:COG2244 145 LLALINILSSLLSLLLALLL--------------ALLGLGLWGL--------------------------VLKYSLPLLL 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 248 GVSISQINLLLDTVIASLLMT-GSIAWLYYSDRLIEFPLgLFGIGIATVILPALSKLHSSKKSSDFQHTLDWGVRFVIFL 326
Cdd:COG2244 185 SGLLGLLLTNLDRLLLGALLGpAAVGIYSAAYRLASLLL-LLITALSQVLFPRLSRLLAEGDREELRRLYRKALRLLLLL 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 327 GLPAMIGLMIISPLIITVLFdhgafkeaGIDHVKAVSLgVVAYSVGLVSFMLIKVLAPGFYSRQDTKTPVRIGIVTLVLN 406
Cdd:COG2244 264 GLPLALGLALLAPPLLSLLF--------GPEYAEAAPV-LPILALGALFLALSGVLSNLLLALGRTRLLLIISLIGAVLN 334
|
330 340 350
....*....|....*....|....*....|..
gi 2278028608 407 MVFNIMLAPFIGYLGLALATSMSASCNAYLLY 438
Cdd:COG2244 335 LVLNLLLIPRYGLVGAAIATLLSYLVLLLLLL 366
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
236-439 |
1.57e-04 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 44.04 E-value: 1.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 236 KKVRKLMLPALFGVSISQINLLLDTVIASLLMTGSIAWLYYSDRLIEFPLGLF-GIGIATVILPALSKLHSSKKssDFQH 314
Cdd:cd13137 1 RRIWSLAWPVILENLLQTLVGLVDVFMVGRLGAEAIAAVGLATQVLWLLLVLNmALGTGTVALVSQSYGAGDYE--RARR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 315 TLDWGVRFVIFLGLPAMIGLMIISPLIITVLFDHGAFKEAGIDHVKAVSLGVVAYSVGLVSFMLikvlapgFYSRQDTKT 394
Cdd:cd13137 79 ALGQSLLLALLLSLPLALLGLLFAEPLLRLLGADPEVIALALTYLRIVLLGIPFFFLSLVGNAA-------LRGAGDTKT 151
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 2278028608 395 PVRIGIVTLVLNMVFNIML------APFIGYLGLALAT----SMSASCNAYLLYR 439
Cdd:cd13137 152 PMYIMIIVNVLNIVLDYVLifglwgFPGLGVAGAALATvisrVVGALLLLFLLLR 206
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
41-424 |
3.30e-03 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 40.00 E-value: 3.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 41 DVFLFANRIPNFLRRLFAEGAFAQAFVPVLSEIKQQQgdeKVRIFVAQAAGTLGTILLIVTLFGVIASPVIAALFGTgwf 120
Cdd:cd12082 32 AVGLAFPLIALLIALGVGLSVGTSALISQAIGAGDEE---KARRVLVQSIVLAILLGLLLAALLLFFSPLILSLLGA--- 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 121 idwwqggpDAEKFELASSLLKLTFPYLFFVSLVALSGAVMNVYNRFAVAAFTPVLLNV-SIIGCAILLHDQFSV--GAYA 197
Cdd:cd12082 106 --------EEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLlNILLDPLLIFGLGPPelGIAG 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 198 LAIGVFLGGVVQLLFQLPFLYKAKMLARPRWGWQDENVKKVRKLM---LPALFGVSISQINLLLDTVIASLLM-TGSIAW 273
Cdd:cd12082 178 AALATVISYVIGALLLLIYLRKGKKILKFKLSLLKPDLELLRRLLrigLPSAIQNSLLSLGLLIIVAIVAAFGgAAALAA 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 274 LYYSDRLIEFPLgLFGIGIATVILPALSKLHSSKKSSDFQHTLDWGVRFVIFLGLPAMIGLMIISPLIITVLFDHGAFKE 353
Cdd:cd12082 258 YTVAFRIASLAF-MPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLGLLILLFPEPILSLFTNDPEFLE 336
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2278028608 354 AGIDHVKAVSLGVVAYSVGLvsfmlikVLAPGFYSRQDTKTPVrigIVTLVLNMVFNIMLAPFIGYLGLAL 424
Cdd:cd12082 337 LAVSYLRILAIYYLFVGIGY-------VLQAGFQAAGRTLKSL---IVSLLSYWVVRLPLAYVLAYLGLGL 397
|
|
| Polysacc_synt_3 |
pfam13440 |
Polysaccharide biosynthesis protein; |
147-346 |
9.08e-03 |
|
Polysaccharide biosynthesis protein;
Pssm-ID: 404342 [Multi-domain] Cd Length: 293 Bit Score: 38.34 E-value: 9.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 147 LFFVSLVALSGAVMNVYNRFAVAAFTPVLLNVSIIGCAILLHdQFSVGAYALAIGVFLGGVVQLLFQLPFLYKakmlaRP 226
Cdd:pfam13440 92 LILNGLSSVQTALLRRDLRFKKLFKITLTSSVIGGIVGIVLA-YLGFGVWALVIGTLAQQLLSLVLLWLASDW-----RP 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 227 RWGWQDENVKKVRKLMLPALFGVSISQINLLLDTVIASLLMTGSIAWLY-YSDRLIEFPLGLFGIGIATVILPALSKLHS 305
Cdd:pfam13440 166 RLTFSLKVIKELFSFGSWLLLSNLLNYLARNLDNLIIGKVLGTAALGLYsVAYRLALLPTANITSVITKVLFPALSRIQD 245
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 2278028608 306 SKKssDFQHTLDWGVRFVIFLGLPAMIGLMIISPLIITVLF 346
Cdd:pfam13440 246 DKA--KLRELYLRVLRLIAFIVFPIMAGLAVVAEPLVLVLL 284
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
244-444 |
9.69e-03 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 38.38 E-value: 9.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 244 PALFGVSISQINLLLDTVIASLLMTGSIAWLYYSDRLIeFPLGLFGIGIATVILPALSKLHSSKKSSDFQHTLDWGVRFV 323
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLGSSVF-MFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 324 IFLGLPAMIGLMIISPLIITVLFDHGAFKEAGIDHVKAVSLGVVAYSVGLVSFMLIKvlapgfySRQDTKTPVRIGIVTL 403
Cdd:TIGR00797 80 LLLGLPVLLVGYFFIDPLLSLMGADGEVAELAQDYLRILILGIPAYLLNFVLRGFLR-------GQGDTKTPMYITLIGN 152
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 2278028608 404 VLNMVFNIML----APFIGYLGLALATSMS--ASCNAYLLYRQLKKE 444
Cdd:TIGR00797 153 VINIILNYILifgkFGFLGIVGAALATVISywLMFLLLLYYIKKAKK 199
|
|
| MATE_tuaB_like |
cd13127 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This ... |
98-443 |
9.86e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This family might function as a translocase for lipopolysaccharides and participate in the biosynthesis of cell wall components such as teichuronic acid. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240532 [Multi-domain] Cd Length: 406 Bit Score: 38.23 E-value: 9.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 98 LIVTLFGVIASPVIAALFGTgwfidwwqggpdaekfELASSLLKLTFPYLFFVSLVALSGAVMNVYNRF---AVAAFTPV 174
Cdd:cd13127 83 LLLYLLLFLLAPLIAAFYNE----------------PELIPLLRVLSLSFLLSGLGSVPRALLQRELRFkklAIIELIST 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 175 LLNVSI-IGCAILLHdqfsvGAYALAIGVFLGGVVQLLFqlpFLYKAKmlARPRWGWQDENVKKVRKLMLPALFGVSISQ 253
Cdd:cd13127 147 LVSGVVaIVLALLGF-----GVWALVAQQLVGALVSTVL---LWILSR--WRPRLSFSLASLKELLSFGSKLLGSNLLNY 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 254 INLLLDTVIASLLMTGSIAWLYY-SDRLIEFPLGLFGIGIATVILPALSklhsskkssDFQHTLD-------WGVRFVIF 325
Cdd:cd13127 217 FSRNLDNLIIGKFLGAAALGYYSrAYRLALLPVQNITGPITRVLFPALS---------RLQDDPErlrraylKALRLLAL 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278028608 326 LGLPAMIGLMIISPLIITVLFdhgafkeaGIDHVKAVSLgVVAYSVGLVSFMLIKVLAPGFYSRQDTKTPVRIGIVTLVL 405
Cdd:cd13127 288 ITFPLMVGLALLAEPLVLLLL--------GEKWLPAVPI-LQILALAGLFQPLSSLNGSLLLALGRTDLLLKLGLIKAVL 358
|
330 340 350
....*....|....*....|....*....|....*...
gi 2278028608 406 NMVFnIMLAPFIGYLGLALATSMSASCNAYLLYRQLKK 443
Cdd:cd13127 359 TVLA-LLIGIPYGIIGVAIAYVIASLLSFPLNLYLAGR 395
|
|
| |
