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Conserved domains on  [gi|2278603269|ref|WP_255494611|]
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type II secretion system protein [Agarivorans sp. Alg241-V36]

Protein Classification

type II secretion system protein( domain architecture ID 11450365)

type II secretion system protein similar to Pseudomonas aeruginosa type II secretion system protein H, which is involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins; required for the translocation of a variety of enzymes across the outer membrane; pilin similar to fimbrial protein PilE, which is required for pilus biogenesis, as well as fimbrial protein PilA, which is responsible for the adhesive property of the pilus

Gene Ontology:  GO:0005886|GO:0015628|GO:0015627
PubMed:  30767847|1365398

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PulG COG2165
Type II secretory pathway, pseudopilin PulG [Cell motility, Intracellular trafficking, ...
 1-86 8.61e-13

Type II secretory pathway, pseudopilin PulG [Cell motility, Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


:

Pssm-ID: 441768 [Multi-domain]  Cd Length: 99  Bit Score: 61.08  E-value: 8.61e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278603269   1 MSKRAGFTLIELVLVIVILAVLSVVALPKFISLRLDSKAATLEAVGGAMREGLHLVYSE-----AALQNQISGNGEIDYL 75
Cdd:COG2165     7 RRRQRGFTLIELLVVIAIIGILAALALPALQGARERARRAELRSNLRQIQQALERYRLDngrypSSLTGLLADVRGGGYL 86

                          90
                  ....*....|.
gi 2278603269  76 GVQLPVYQGYP 86
Cdd:COG2165    87 GSNGLPPAGTP 97
 
Name Accession Description Interval E-value
PulG COG2165
Type II secretory pathway, pseudopilin PulG [Cell motility, Intracellular trafficking, ...
 1-86 8.61e-13

Type II secretory pathway, pseudopilin PulG [Cell motility, Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 441768 [Multi-domain]  Cd Length: 99  Bit Score: 61.08  E-value: 8.61e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278603269   1 MSKRAGFTLIELVLVIVILAVLSVVALPKFISLRLDSKAATLEAVGGAMREGLHLVYSE-----AALQNQISGNGEIDYL 75
Cdd:COG2165     7 RRRQRGFTLIELLVVIAIIGILAALALPALQGARERARRAELRSNLRQIQQALERYRLDngrypSSLTGLLADVRGGGYL 86

                          90
                  ....*....|.
gi 2278603269  76 GVQLPVYQGYP 86
Cdd:COG2165    87 GSNGLPPAGTP 97
PRK10574 PRK10574
putative major pilin subunit; Provisional
 1-28 3.09e-06

putative major pilin subunit; Provisional


Pssm-ID: 236718 [Multi-domain]  Cd Length: 146  Bit Score: 44.64  E-value: 3.09e-06
                          10        20
                  ....*....|....*....|....*...
gi 2278603269   1 MSKRAGFTLIELVLVIVILAVLSVVALP 28
Cdd:PRK10574    1 MDKQRGFTLIELMVVIAIIAILSAIGIP 28
N_methyl pfam07963
Prokaryotic N-terminal methylation motif; This short motif directs methylation of the ...
 1-27 4.03e-06

Prokaryotic N-terminal methylation motif; This short motif directs methylation of the conserved phenylalanine residue. It is most often found at the N-terminus of pilins and other proteins involved in secretion, see pfam00114, pfam05946, pfam02501 and pfam07596.


Pssm-ID: 429756 [Multi-domain]  Cd Length: 27  Bit Score: 41.59  E-value: 4.03e-06
                          10        20
                  ....*....|....*....|....*..
gi 2278603269   1 MSKRAGFTLIELVLVIVILAVLSVVAL 27
Cdd:pfam07963   1 MRKQRGFTLIELLVALAILAILLAAAL 27
IV_pilin_GFxxxE TIGR02532
prepilin-type N-terminal cleavage/methylation domain; This model describes many but not all ...
 4-27 1.26e-04

prepilin-type N-terminal cleavage/methylation domain; This model describes many but not all examples of the N-terminal region of bacterial proteins that resemble type IV pilins at their N-terminus, with a cleavage site G^FxxxE followed by a hydrophobic stretch. The new N-terminal residue, usually Phe, is methylated. Separate domains of the prepilin peptidase appear responsible for cleavage and methylation. Proteins with this N-terminal region include type IV pilins and other components of pilus biogenesis, competence proteins, and type II secretion proteins. Typically several proteins in a single operon have this N-terminal domain. The N-terminal cleavage and methylation site is described by PROSITE motif PS00409 as [KRHEQSTAG]-G-[FYLIVM]-[ST]-[LT]-[LIVP]-E-[LIVMFWSTAG](14). [Cell envelope, Surface structures, Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274182 [Multi-domain]  Cd Length: 24  Bit Score: 37.67  E-value: 1.26e-04
                          10        20
                  ....*....|....*....|....
gi 2278603269   4 RAGFTLIELVLVIVILAVLSVVAL 27
Cdd:TIGR02532   1 QRGFTLIELLVVLAILGILALIAL 24
 
Name Accession Description Interval E-value
PulG COG2165
Type II secretory pathway, pseudopilin PulG [Cell motility, Intracellular trafficking, ...
 1-86 8.61e-13

Type II secretory pathway, pseudopilin PulG [Cell motility, Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 441768 [Multi-domain]  Cd Length: 99  Bit Score: 61.08  E-value: 8.61e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278603269   1 MSKRAGFTLIELVLVIVILAVLSVVALPKFISLRLDSKAATLEAVGGAMREGLHLVYSE-----AALQNQISGNGEIDYL 75
Cdd:COG2165     7 RRRQRGFTLIELLVVIAIIGILAALALPALQGARERARRAELRSNLRQIQQALERYRLDngrypSSLTGLLADVRGGGYL 86

                          90
                  ....*....|.
gi 2278603269  76 GVQLPVYQGYP 86
Cdd:COG2165    87 GSNGLPPAGTP 97
FimT COG4970
Type IV pilus assembly protein FimT [Cell motility, Extracellular structures];
1-65 8.80e-12

Type IV pilus assembly protein FimT [Cell motility, Extracellular structures];


Pssm-ID: 443996 [Multi-domain]  Cd Length: 73  Bit Score: 57.55  E-value: 8.80e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2278603269   1 MSKRAGFTLIELVLVIVILAVLSVVALPKFISLRLDSKaatLEAVGGAMREGLHLVYSEAALQNQ 65
Cdd:COG4970     5 RRRQRGFTLIELLVVLAILAILAAIAVPSFSSLIARQR---LRAAANELAAALRLARSEAIRRGQ 66
PilE COG4968
Type IV pilus assembly protein PilE [Cell motility, Extracellular structures];
1-44 2.54e-08

Type IV pilus assembly protein PilE [Cell motility, Extracellular structures];


Pssm-ID: 443994 [Multi-domain]  Cd Length: 124  Bit Score: 49.69  E-value: 2.54e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2278603269   1 MSKRAGFTLIELVLVIVILAVLSVVALPKFISLRLDSKAATLEA 44
Cdd:COG4968     6 RRRQRGFTLIELMIVVAIIGILAAIAIPSYQDYVERARRAEAKA 49
ComGC COG4537
Competence protein ComGC [Mobilome: prophages, transposons];
1-44 2.62e-06

Competence protein ComGC [Mobilome: prophages, transposons];


Pssm-ID: 443603 [Multi-domain]  Cd Length: 108  Bit Score: 44.15  E-value: 2.62e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2278603269   1 MSKRAGFTLIELVLVIVILAVLSVVALPKFISLRLDSKAATLEA 44
Cdd:COG4537     8 LKKEKGFTLIEMLIVLLIISILLLIAVPNLTKQRETAQEKGCEA 51
PilA COG4969
Type IV pilus assembly protein, major pilin PilA [Cell motility, Extracellular structures];
6-30 3.03e-06

Type IV pilus assembly protein, major pilin PilA [Cell motility, Extracellular structures];


Pssm-ID: 443995 [Multi-domain]  Cd Length: 134  Bit Score: 44.31  E-value: 3.03e-06
                          10        20
                  ....*....|....*....|....*
gi 2278603269   6 GFTLIELVLVIVILAVLSVVALPKF 30
Cdd:COG4969     7 GFTLIELMIVVAIIGILAAIAIPAY 31
PRK10574 PRK10574
putative major pilin subunit; Provisional
 1-28 3.09e-06

putative major pilin subunit; Provisional


Pssm-ID: 236718 [Multi-domain]  Cd Length: 146  Bit Score: 44.64  E-value: 3.09e-06
                          10        20
                  ....*....|....*....|....*...
gi 2278603269   1 MSKRAGFTLIELVLVIVILAVLSVVALP 28
Cdd:PRK10574    1 MDKQRGFTLIELMVVIAIIAILSAIGIP 28
N_methyl pfam07963
Prokaryotic N-terminal methylation motif; This short motif directs methylation of the ...
 1-27 4.03e-06

Prokaryotic N-terminal methylation motif; This short motif directs methylation of the conserved phenylalanine residue. It is most often found at the N-terminus of pilins and other proteins involved in secretion, see pfam00114, pfam05946, pfam02501 and pfam07596.


Pssm-ID: 429756 [Multi-domain]  Cd Length: 27  Bit Score: 41.59  E-value: 4.03e-06
                          10        20
                  ....*....|....*....|....*..
gi 2278603269   1 MSKRAGFTLIELVLVIVILAVLSVVAL 27
Cdd:pfam07963   1 MRKQRGFTLIELLVALAILAILLAAAL 27
PulJ COG4795
Type II secretory pathway, PulJ/GspJ component [Intracellular trafficking, secretion, and ...
 1-26 8.70e-05

Type II secretory pathway, PulJ/GspJ component [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 443823 [Multi-domain]  Cd Length: 118  Bit Score: 40.00  E-value: 8.70e-05
                          10        20
                  ....*....|....*....|....*.
gi 2278603269   1 MSKRAGFTLIELVLVIVILAVLSVVA 26
Cdd:COG4795     5 RRRQRGFTLLELLVALAIFALLLLAA 30
IV_pilin_GFxxxE TIGR02532
prepilin-type N-terminal cleavage/methylation domain; This model describes many but not all ...
 4-27 1.26e-04

prepilin-type N-terminal cleavage/methylation domain; This model describes many but not all examples of the N-terminal region of bacterial proteins that resemble type IV pilins at their N-terminus, with a cleavage site G^FxxxE followed by a hydrophobic stretch. The new N-terminal residue, usually Phe, is methylated. Separate domains of the prepilin peptidase appear responsible for cleavage and methylation. Proteins with this N-terminal region include type IV pilins and other components of pilus biogenesis, competence proteins, and type II secretion proteins. Typically several proteins in a single operon have this N-terminal domain. The N-terminal cleavage and methylation site is described by PROSITE motif PS00409 as [KRHEQSTAG]-G-[FYLIVM]-[ST]-[LT]-[LIVP]-E-[LIVMFWSTAG](14). [Cell envelope, Surface structures, Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274182 [Multi-domain]  Cd Length: 24  Bit Score: 37.67  E-value: 1.26e-04
                          10        20
                  ....*....|....*....|....
gi 2278603269   4 RAGFTLIELVLVIVILAVLSVVAL 27
Cdd:TIGR02532   1 QRGFTLIELLVVLAILGILALIAL 24
typeII_sec_gspG TIGR01710
type II secretion system protein G; This model represents GspG, protein G of the main terminal ...
 6-49 8.11e-04

type II secretion system protein G; This model represents GspG, protein G of the main terminal branch of the general secretion pathway, also called type II secretion. It transports folded proteins across the bacterial outer membrane and is widely distributed in Gram-negative pathogens. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 130771 [Multi-domain]  Cd Length: 134  Bit Score: 37.79  E-value: 8.11e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2278603269   6 GFTLIELVLVIVILAVLSVVALPKFISLRLDSKA----ATLEAVGGAM 49
Cdd:TIGR01710   2 GFTLLEIMVVLVILGLLAALVAPKLFSQADKAKAqvakAQIKALKNAL 49
PRK10506 PRK10506
prepilin peptidase-dependent protein;
1-24 5.94e-03

prepilin peptidase-dependent protein;


Pssm-ID: 236704 [Multi-domain]  Cd Length: 162  Bit Score: 35.74  E-value: 5.94e-03
                          10        20
                  ....*....|....*....|....
gi 2278603269   1 MSKRAGFTLIELVLVIVILAVLSV 24
Cdd:PRK10506    5 MKKQRGYTLIELLVVMTIVSILSA 28
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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