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Conserved domains on  [gi|2285291011|ref|WP_257652063|]
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MULTISPECIES: HNH endonuclease [Citrobacter]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG3183 COG3183
Predicted restriction endonuclease, HNH family [Defense mechanisms];
134-241 5.37e-45

Predicted restriction endonuclease, HNH family [Defense mechanisms];


:

Pssm-ID: 442416 [Multi-domain]  Cd Length: 112  Bit Score: 146.68  E-value: 5.37e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285291011 134 EVEEHYYEGDRKTKWSTYYERNPKARKECLDFHGYSCKVCKFNFEKTYGDLGKEFIHVHHIKPISvEKKKHKVDPIKDLI 213
Cdd:COG3183     3 EEPKGFTEGAKKEVTHKRYERNPKLRKKAKEHAGGKCEVCGFDFEFVYGELGEGYIEVHHLIPLS-EIGEGGVDPIEDLV 81

                          90       100
                  ....*....|....*....|....*...
gi 2285291011 214 PVCANCHAMLHIGQDVLTLDQLRAKIRK 241
Cdd:COG3183    82 PLCPNCHRMLHRGRPPLSIEELKKLLKR 109
 
Name Accession Description Interval E-value
COG3183 COG3183
Predicted restriction endonuclease, HNH family [Defense mechanisms];
134-241 5.37e-45

Predicted restriction endonuclease, HNH family [Defense mechanisms];


Pssm-ID: 442416 [Multi-domain]  Cd Length: 112  Bit Score: 146.68  E-value: 5.37e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285291011 134 EVEEHYYEGDRKTKWSTYYERNPKARKECLDFHGYSCKVCKFNFEKTYGDLGKEFIHVHHIKPISvEKKKHKVDPIKDLI 213
Cdd:COG3183     3 EEPKGFTEGAKKEVTHKRYERNPKLRKKAKEHAGGKCEVCGFDFEFVYGELGEGYIEVHHLIPLS-EIGEGGVDPIEDLV 81

                          90       100
                  ....*....|....*....|....*...
gi 2285291011 214 PVCANCHAMLHIGQDVLTLDQLRAKIRK 241
Cdd:COG3183    82 PLCPNCHRMLHRGRPPLSIEELKKLLKR 109
HNHc cd00085
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic ...
 166-224 1.22e-05

HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.


Pssm-ID: 238038 [Multi-domain]  Cd Length: 57  Bit Score: 41.69  E-value: 1.22e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2285291011 166 HGYSCKVCKFNFektygdlGKEFIHVHHIKPIsvekKKHKVDPIKDLIPVCANCHAMLH 224
Cdd:cd00085    10 RDGLCPYCGKPG-------GTEGLEVDHIIPL----SDGGNNDLDNLVLLCRKCHRKKH 57
HNH pfam01844
HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic ...
 170-224 8.78e-05

HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic acid-binding proteins that are generally associated with endonuclease activity.


Pssm-ID: 396422 [Multi-domain]  Cd Length: 47  Bit Score: 39.26  E-value: 8.78e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2285291011 170 CKVCKFNFEKTYgdlgkeFIHVHHIKPISVEKKkhkvDPIKDLIPVCANCHAMLH 224
Cdd:pfam01844   1 CQYCGRPFHISD------ALTVDHIIPLSDGGA----DDIENLILLCPSCHNKKH 45
HNHc smart00507
HNH nucleases;
167-220 6.27e-03

HNH nucleases;


Pssm-ID: 214702 [Multi-domain]  Cd Length: 52  Bit Score: 33.97  E-value: 6.27e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2285291011  167 GYSCKVCkfnfektyGDLGKEFIHVHHIKPISvekkKHKVDPIKDLIPVCANCH 220
Cdd:smart00507  10 DGVCAYC--------GKPASEGLEVDHIIPLS----DGGNDDLDNLVLLCPKCH 51
 
Name Accession Description Interval E-value
COG3183 COG3183
Predicted restriction endonuclease, HNH family [Defense mechanisms];
134-241 5.37e-45

Predicted restriction endonuclease, HNH family [Defense mechanisms];


Pssm-ID: 442416 [Multi-domain]  Cd Length: 112  Bit Score: 146.68  E-value: 5.37e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285291011 134 EVEEHYYEGDRKTKWSTYYERNPKARKECLDFHGYSCKVCKFNFEKTYGDLGKEFIHVHHIKPISvEKKKHKVDPIKDLI 213
Cdd:COG3183     3 EEPKGFTEGAKKEVTHKRYERNPKLRKKAKEHAGGKCEVCGFDFEFVYGELGEGYIEVHHLIPLS-EIGEGGVDPIEDLV 81

                          90       100
                  ....*....|....*....|....*...
gi 2285291011 214 PVCANCHAMLHIGQDVLTLDQLRAKIRK 241
Cdd:COG3183    82 PLCPNCHRMLHRGRPPLSIEELKKLLKR 109
HNHc cd00085
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic ...
 166-224 1.22e-05

HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.


Pssm-ID: 238038 [Multi-domain]  Cd Length: 57  Bit Score: 41.69  E-value: 1.22e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2285291011 166 HGYSCKVCKFNFektygdlGKEFIHVHHIKPIsvekKKHKVDPIKDLIPVCANCHAMLH 224
Cdd:cd00085    10 RDGLCPYCGKPG-------GTEGLEVDHIIPL----SDGGNNDLDNLVLLCRKCHRKKH 57
HNH pfam01844
HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic ...
 170-224 8.78e-05

HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic acid-binding proteins that are generally associated with endonuclease activity.


Pssm-ID: 396422 [Multi-domain]  Cd Length: 47  Bit Score: 39.26  E-value: 8.78e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2285291011 170 CKVCKFNFEKTYgdlgkeFIHVHHIKPISVEKKkhkvDPIKDLIPVCANCHAMLH 224
Cdd:pfam01844   1 CQYCGRPFHISD------ALTVDHIIPLSDGGA----DDIENLILLCPSCHNKKH 45
HNHc smart00507
HNH nucleases;
167-220 6.27e-03

HNH nucleases;


Pssm-ID: 214702 [Multi-domain]  Cd Length: 52  Bit Score: 33.97  E-value: 6.27e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2285291011  167 GYSCKVCkfnfektyGDLGKEFIHVHHIKPISvekkKHKVDPIKDLIPVCANCH 220
Cdd:smart00507  10 DGVCAYC--------GKPASEGLEVDHIIPLS----DGGNDDLDNLVLLCPKCH 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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