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Conserved domains on  [gi|2288158872|ref|WP_258126396|]
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hypothetical protein [Bacillus sp. IBL03825]

Protein Classification

WD40/YVTN/BNR-like repeat-containing protein( domain architecture ID 11468233)

WD40/YVTN/BNR-like repeat-containing protein similar to plant photosynthesis system II assembly factor Ycf48, and some glycosylhydrolases

PubMed:  18550538|21531723

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4447 COG4447
Uncharacterized conserved protein related to plant photosystem II stability/assembly factor ...
 51-134 3.60e-10

Uncharacterized conserved protein related to plant photosystem II stability/assembly factor [General function prediction only];


:

Pssm-ID: 443546 [Multi-domain]  Cd Length: 156  Bit Score: 57.32  E-value: 3.60e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2288158872  51 SEDNVVYGVGDEGIFIRSMNGGENWTVQRFPTKATSWN--VCSNVQGTVIAHGDKTLYHSNDFGSTWETIHPfleyGGGA 128
Cdd:COG4447     1 ADGNRLWAVGASGGILRSTDGGKTWTPLSDGLPGLSLRavAFSDPNTVWVGTGPGGIYRSTDGGKTWTEVNS----GPDN 76


                  ....*.
gi 2288158872 129 PSIRSL 134
Cdd:COG4447    77 PRLFAI 82
 
Name Accession Description Interval E-value
COG4447 COG4447
Uncharacterized conserved protein related to plant photosystem II stability/assembly factor ...
 51-134 3.60e-10

Uncharacterized conserved protein related to plant photosystem II stability/assembly factor [General function prediction only];


Pssm-ID: 443546 [Multi-domain]  Cd Length: 156  Bit Score: 57.32  E-value: 3.60e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2288158872  51 SEDNVVYGVGDEGIFIRSMNGGENWTVQRFPTKATSWN--VCSNVQGTVIAHGDKTLYHSNDFGSTWETIHPfleyGGGA 128
Cdd:COG4447     1 ADGNRLWAVGASGGILRSTDGGKTWTPLSDGLPGLSLRavAFSDPNTVWVGTGPGGIYRSTDGGKTWTEVNS----GPDN 76


                  ....*.
gi 2288158872 129 PSIRSL 134
Cdd:COG4447    77 PRLFAI 82
Sortilin-Vps10 pfam15902
Sortilin, neurotensin receptor 3,; Sortilin, also known in mammals as neurotensin receptor-3, ...
 27-119 3.88e-03

Sortilin, neurotensin receptor 3,; Sortilin, also known in mammals as neurotensin receptor-3, is the archetypical member of a Vps10-domain (Vps10-D) that binds neurotrophic factors and neuropeptides. This domain constitutes the entire luminal part of Sortilin and is activated in the trans-Golgi network by enzymatic propeptide cleavage. The structure of the domain has been determined as a ten-bladed propeller, with up to 9 BNR or beta-hairpin turns in it. The mature receptor binds various ligands, including its own propeptide (Sort-pro), neurotensin, the pro-forms of nerve growth factor-beta (NGF)6 and brain-derived neurotrophic factor (BDNF)7, lipoprotein lipase (LpL), apo lipoprotein AV14 and the receptor-associated protein (RAP)1.


Pssm-ID: 464929 [Multi-domain]  Cd Length: 444  Bit Score: 38.72  E-value: 3.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2288158872  27 LFIERDG--EWKQILNGFQKRIRDL---HSEDN-VVYGVGDEGIFIRSMNGGENWTVQRFPTKAtswNVCSNV------- 93
Cdd:pfam15902   3 VYRSHDYgkTWKKVKDVPDGEAILAiypHPYDNdRAYLLTDGKKHYYTTDRGKTFRSFKLPFPP---NLFGPPlsfhpkd 79

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2288158872  94 QGTVIAHG--------DKTLYHSNDFGSTWETIH 119
Cdd:pfam15902  80 PDWLIWYGgkcfsgdcHSVAYYSTDGGKSWKLLL 113
 
Name Accession Description Interval E-value
COG4447 COG4447
Uncharacterized conserved protein related to plant photosystem II stability/assembly factor ...
 51-134 3.60e-10

Uncharacterized conserved protein related to plant photosystem II stability/assembly factor [General function prediction only];


Pssm-ID: 443546 [Multi-domain]  Cd Length: 156  Bit Score: 57.32  E-value: 3.60e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2288158872  51 SEDNVVYGVGDEGIFIRSMNGGENWTVQRFPTKATSWN--VCSNVQGTVIAHGDKTLYHSNDFGSTWETIHPfleyGGGA 128
Cdd:COG4447     1 ADGNRLWAVGASGGILRSTDGGKTWTPLSDGLPGLSLRavAFSDPNTVWVGTGPGGIYRSTDGGKTWTEVNS----GPDN 76


                  ....*.
gi 2288158872 129 PSIRSL 134
Cdd:COG4447    77 PRLFAI 82
COG4447 COG4447
Uncharacterized conserved protein related to plant photosystem II stability/assembly factor ...
 35-124 2.99e-07

Uncharacterized conserved protein related to plant photosystem II stability/assembly factor [General function prediction only];


Pssm-ID: 443546 [Multi-domain]  Cd Length: 156  Bit Score: 49.23  E-value: 2.99e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2288158872  35 WKQILNGFQK-RIRDLH-SEDNVVYGVGDEGIFIRSMNGGENWTVQRFPTKATSWN--VCSNVQ-GTVIAHGdktLYHSN 109
Cdd:COG4447    25 WTPLSDGLPGlSLRAVAfSDPNTVWVGTGPGGIYRSTDGGKTWTEVNSGPDNPRLFaiAFSDPNtGYAAVGG---IYRTT 101

                          90
                  ....*....|....*
gi 2288158872 110 DFGSTWETIHPFLEY 124
Cdd:COG4447   102 DGGKTWTKVSSGLPV 116
COG4447 COG4447
Uncharacterized conserved protein related to plant photosystem II stability/assembly factor ...
 8-115 6.13e-04

Uncharacterized conserved protein related to plant photosystem II stability/assembly factor [General function prediction only];


Pssm-ID: 443546 [Multi-domain]  Cd Length: 156  Bit Score: 39.60  E-value: 6.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2288158872   8 TAITKLRDGKLMLATTYNGLFIERDG--EWKQILNG-FQKRIRDLHSED-NVVYgVGDEGIFiRSMNGGENWTVQRFPTK 83
Cdd:COG4447    38 RAVAFSDPNTVWVGTGPGGIYRSTDGgkTWTEVNSGpDNPRLFAIAFSDpNTGY-AAVGGIY-RTTDGGKTWTKVSSGLP 115

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2288158872  84 ATSWNVCSNVQGTVIAHG---------DKTLYHSNDFGSTW 115
Cdd:COG4447   116 VDLNDVAFLDPGTLYAAGeggliyrstDGGEYRSTDGGKTW 156
Sortilin-Vps10 pfam15902
Sortilin, neurotensin receptor 3,; Sortilin, also known in mammals as neurotensin receptor-3, ...
 27-119 3.88e-03

Sortilin, neurotensin receptor 3,; Sortilin, also known in mammals as neurotensin receptor-3, is the archetypical member of a Vps10-domain (Vps10-D) that binds neurotrophic factors and neuropeptides. This domain constitutes the entire luminal part of Sortilin and is activated in the trans-Golgi network by enzymatic propeptide cleavage. The structure of the domain has been determined as a ten-bladed propeller, with up to 9 BNR or beta-hairpin turns in it. The mature receptor binds various ligands, including its own propeptide (Sort-pro), neurotensin, the pro-forms of nerve growth factor-beta (NGF)6 and brain-derived neurotrophic factor (BDNF)7, lipoprotein lipase (LpL), apo lipoprotein AV14 and the receptor-associated protein (RAP)1.


Pssm-ID: 464929 [Multi-domain]  Cd Length: 444  Bit Score: 38.72  E-value: 3.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2288158872  27 LFIERDG--EWKQILNGFQKRIRDL---HSEDN-VVYGVGDEGIFIRSMNGGENWTVQRFPTKAtswNVCSNV------- 93
Cdd:pfam15902   3 VYRSHDYgkTWKKVKDVPDGEAILAiypHPYDNdRAYLLTDGKKHYYTTDRGKTFRSFKLPFPP---NLFGPPlsfhpkd 79

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2288158872  94 QGTVIAHG--------DKTLYHSNDFGSTWETIH 119
Cdd:pfam15902  80 PDWLIWYGgkcfsgdcHSVAYYSTDGGKSWKLLL 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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