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Conserved domains on  [gi|2294385671|ref|WP_259297201|]
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lipopolysaccharide assembly protein LapB [Streptomyces griseoaurantiacus]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11459274)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 95-342 2.21e-20

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 90.94  E-value: 2.21e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671  95 DDLAASIRGLQAHLRAQPRDAEAWSTLALAYVEQARTEgdpsrypQADKALDRALELRPHHDPALAGRAALAAARHDFRG 174
Cdd:COG2956    22 GQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYD-------RAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDR 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 175 ALKYADEALSRNPYNERALCSRIDALVELGRYEEASKAADLADSRRPGVPVF-TRYAYVRELRGDTATAREVLTRALgta 253
Cdd:COG2956    95 AEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAyCELAELYLEQGDYDEAIEALEKAL--- 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 254 ATRGDVAYVATALGQLAWNQGQYRTALRHYARALAADDTYLPALEGRARTQAALGDRAAAITGMERVVARAPLPQPLVEL 333
Cdd:COG2956   172 KLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDLLLAL 251


                  ....*....
gi 2294385671 334 GELYEERGG 342
Cdd:COG2956   252 ADLLERKEG 260
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 235-467 5.82e-09

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 57.05  E-value: 5.82e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 235 LRGDTATAREVLTRALgtaATRGDVAYVATALGQLAWNQGQYRTALRHYARALAADDTYLPALEGRARTQAALGDRAAAI 314
Cdd:COG2956    20 LNGQPDKAIDLLEEAL---ELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAE 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 315 TGMERVVARAPL-PQPLVELGELYEERGgkgDTARARDQY--------ALVHAWVSLARAngvdadldtalaAADHGERG 385
Cdd:COG2956    97 ELLEKLLELDPDdAEALRLLAEIYEQEG---DWEKAIEVLerllklgpENAHAYCELAEL------------YLEQGDYD 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 386 AALKAA-RAEWKRRHTVHTADALAWALHVNGRDEEALPYARRATATGYRSASFRYHRGMIERAAGRPDRARASLTAALGL 464
Cdd:COG2956   162 EAIEALeKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALEL 241


                  ...
gi 2294385671 465 NPG 467
Cdd:COG2956   242 DPS 244
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 95-342 2.21e-20

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 90.94  E-value: 2.21e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671  95 DDLAASIRGLQAHLRAQPRDAEAWSTLALAYVEQARTEgdpsrypQADKALDRALELRPHHDPALAGRAALAAARHDFRG 174
Cdd:COG2956    22 GQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYD-------RAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDR 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 175 ALKYADEALSRNPYNERALCSRIDALVELGRYEEASKAADLADSRRPGVPVF-TRYAYVRELRGDTATAREVLTRALgta 253
Cdd:COG2956    95 AEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAyCELAELYLEQGDYDEAIEALEKAL--- 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 254 ATRGDVAYVATALGQLAWNQGQYRTALRHYARALAADDTYLPALEGRARTQAALGDRAAAITGMERVVARAPLPQPLVEL 333
Cdd:COG2956   172 KLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDLLLAL 251


                  ....*....
gi 2294385671 334 GELYEERGG 342
Cdd:COG2956   252 ADLLERKEG 260
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 96-468 2.50e-13

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 72.42  E-value: 2.50e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671  96 DLAASIRGLQAHLRAQPRDAEAwsTLALAYVEQARtegdpSRYPQADKALDRALELRPHHDPALAGRAALAAARHDFRGA 175
Cdd:TIGR02917 140 QLELAQKSYEQALAIDPRSLYA--KLGLAQLALAE-----NRFDEARALIDEVLTADPGNVDALLLKGDLLLSLGNIELA 212

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 176 LKYADEALSRNPYNERALCSRIDALVELGRYEEASKAADLADSRRPGVPVFTRY-AYVRELRGDTATAREVLTRALGTAA 254
Cdd:TIGR02917 213 LAAYRKAIALRPNNIAVLLALATILIEAGEFEEAEKHADALLKKAPNSPLAHYLkALVDFQKKNYEDARETLQDALKSAP 292

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 255 TRGDVAYVAtalGQLAWNQGQYRTALRHYARALAADDTYLPALEGRARTQAALGDRAAAITGMERVVARAPL-PQPLVEL 333
Cdd:TIGR02917 293 EYLPALLLA---GASEYQLGNLEQAYQYLNQILKYAPNSHQARRLLASIQLRLGRVDEAIATLSPALGLDPDdPAALSLL 369

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 334 GELYEErggKGDTARARDQYALVHAwvsLARANGVDADLDTALAAADHGERGAA---LKAARAEWKrrhTVHTADALAWA 410
Cdd:TIGR02917 370 GEAYLA---LGDFEKAAEYLAKATE---LDPENAAARTQLGISKLSQGDPSEAIadlETAAQLDPE---LGRADLLLILS 440

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2294385671 411 LHVNGRDEEALPYARRATATGYRSASFRYHRGMIERAAGRPDRARASLTAALGLNPGF 468
Cdd:TIGR02917 441 YLRSGQFDKALAAAKKLEKKQPDNASLHNLLGAIYLGKGDLAKAREAFEKALSIEPDF 498
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 235-467 5.82e-09

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 57.05  E-value: 5.82e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 235 LRGDTATAREVLTRALgtaATRGDVAYVATALGQLAWNQGQYRTALRHYARALAADDTYLPALEGRARTQAALGDRAAAI 314
Cdd:COG2956    20 LNGQPDKAIDLLEEAL---ELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAE 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 315 TGMERVVARAPL-PQPLVELGELYEERGgkgDTARARDQY--------ALVHAWVSLARAngvdadldtalaAADHGERG 385
Cdd:COG2956    97 ELLEKLLELDPDdAEALRLLAEIYEQEG---DWEKAIEVLerllklgpENAHAYCELAEL------------YLEQGDYD 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 386 AALKAA-RAEWKRRHTVHTADALAWALHVNGRDEEALPYARRATATGYRSASFRYHRGMIERAAGRPDRARASLTAALGL 464
Cdd:COG2956   162 EAIEALeKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALEL 241


                  ...
gi 2294385671 465 NPG 467
Cdd:COG2956   242 DPS 244
PRK11788 PRK11788
tetratricopeptide repeat protein; Provisional
 236-342 7.48e-05

tetratricopeptide repeat protein; Provisional


Pssm-ID: 236983 [Multi-domain]  Cd Length: 389  Bit Score: 44.80  E-value: 7.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 236 RGDTATAREVLTRALgtAATRGDV-AYVAtaLGQLAWNQGQYRTALRHYARALAADDTYLP-ALEGRARTQAALGDRAAA 313
Cdd:PRK11788  193 RGDLDAARALLKKAL--AADPQCVrASIL--LGDLALAQGDYAAAIEALERVEEQDPEYLSeVLPKLMECYQALGDEAEG 268

                          90       100
                  ....*....|....*....|....*....
gi 2294385671 314 ITGMERVVARAPLPQPLVELGELYEERGG 342
Cdd:PRK11788  269 LEFLRRALEEYPGADLLLALAQLLEEQEG 297
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 95-342 2.21e-20

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 90.94  E-value: 2.21e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671  95 DDLAASIRGLQAHLRAQPRDAEAWSTLALAYVEQARTEgdpsrypQADKALDRALELRPHHDPALAGRAALAAARHDFRG 174
Cdd:COG2956    22 GQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYD-------RAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDR 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 175 ALKYADEALSRNPYNERALCSRIDALVELGRYEEASKAADLADSRRPGVPVF-TRYAYVRELRGDTATAREVLTRALgta 253
Cdd:COG2956    95 AEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAyCELAELYLEQGDYDEAIEALEKAL--- 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 254 ATRGDVAYVATALGQLAWNQGQYRTALRHYARALAADDTYLPALEGRARTQAALGDRAAAITGMERVVARAPLPQPLVEL 333
Cdd:COG2956   172 KLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDLLLAL 251


                  ....*....
gi 2294385671 334 GELYEERGG 342
Cdd:COG2956   252 ADLLERKEG 260
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 137-353 3.41e-14

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 72.84  E-value: 3.41e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 137 RYPQADKALDRALELRPHHDPALAGRAALAAARHDFRGALKYADEALSRNPYNERALCSRIDALVELGRYEEASKAADLA 216
Cdd:COG2956    23 QPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKL 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 217 DSRRPG-VPVFTRYAYVRELRGDTATAREVLTRALgtaATRGDVAYVATALGQLAWNQGQYRTALRHYARALAADDTYLP 295
Cdd:COG2956   103 LELDPDdAEALRLLAEIYEQEGDWEKAIEVLERLL---KLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCAR 179

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2294385671 296 ALEGRARTQAALGDRAAAITGMERVVARAPLPQP-LVELGELYEERggkGDTARARDQY 353
Cdd:COG2956   180 ALLLLAELYLEQGDYEEAIAALERALEQDPDYLPaLPRLAELYEKL---GDPEEALELL 235
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 96-468 2.50e-13

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 72.42  E-value: 2.50e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671  96 DLAASIRGLQAHLRAQPRDAEAwsTLALAYVEQARtegdpSRYPQADKALDRALELRPHHDPALAGRAALAAARHDFRGA 175
Cdd:TIGR02917 140 QLELAQKSYEQALAIDPRSLYA--KLGLAQLALAE-----NRFDEARALIDEVLTADPGNVDALLLKGDLLLSLGNIELA 212

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 176 LKYADEALSRNPYNERALCSRIDALVELGRYEEASKAADLADSRRPGVPVFTRY-AYVRELRGDTATAREVLTRALGTAA 254
Cdd:TIGR02917 213 LAAYRKAIALRPNNIAVLLALATILIEAGEFEEAEKHADALLKKAPNSPLAHYLkALVDFQKKNYEDARETLQDALKSAP 292

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 255 TRGDVAYVAtalGQLAWNQGQYRTALRHYARALAADDTYLPALEGRARTQAALGDRAAAITGMERVVARAPL-PQPLVEL 333
Cdd:TIGR02917 293 EYLPALLLA---GASEYQLGNLEQAYQYLNQILKYAPNSHQARRLLASIQLRLGRVDEAIATLSPALGLDPDdPAALSLL 369

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 334 GELYEErggKGDTARARDQYALVHAwvsLARANGVDADLDTALAAADHGERGAA---LKAARAEWKrrhTVHTADALAWA 410
Cdd:TIGR02917 370 GEAYLA---LGDFEKAAEYLAKATE---LDPENAAARTQLGISKLSQGDPSEAIadlETAAQLDPE---LGRADLLLILS 440

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2294385671 411 LHVNGRDEEALPYARRATATGYRSASFRYHRGMIERAAGRPDRARASLTAALGLNPGF 468
Cdd:TIGR02917 441 YLRSGQFDKALAAAKKLEKKQPDNASLHNLLGAIYLGKGDLAKAREAFEKALSIEPDF 498
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
108-355 3.03e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 69.27  E-value: 3.03e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 108 LRAQPRDAEAWSTLALAYVEQartegdpSRYPQADKALDRALELRPHHDPALAGRAALAAARHDFRGALKYADEALSRNP 187
Cdd:COG0457     1 LELDPDDAEAYNNLGLAYRRL-------GRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDP 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 188 YNERALCSRIDALVELGRYEEASKAADLADSRRPGVP-VFTRYAYVRELRGDTATAREVLTRALgtaATRGDVAYVATAL 266
Cdd:COG0457    74 DDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAeALYNLGLALLELGRYDEAIEAYERAL---ELDPDDADALYNL 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 267 GQLAWNQGQYRTALRHYARALAADDTYLPALEGRARTQAALGDRAAAITGMERVVARAPLPQPLVELGELYEERGGKGDT 346
Cdd:COG0457   151 GIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALL 230


                  ....*....
gi 2294385671 347 ARARDQYAL 355
Cdd:COG0457   231 LALRLAALA 239
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
171-394 9.01e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 68.11  E-value: 9.01e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 171 DFRGALKYADEALSRNPYNERALCSRIDALVELGRYEEASKAADLADSRRPGVP-VFTRYAYVRELRGDTATAREVLTRA 249
Cdd:COG0457    23 RYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAeALNNLGLALQALGRYEEALEDYDKA 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 250 LgtaATRGDVAYVATALGQLAWNQGQYRTALRHYARALAADDTYLPALEGRARTQAALGDRAAAITGMERVVARAPLPQP 329
Cdd:COG0457   103 L---ELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALL 179

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2294385671 330 LVELGELYEERGGKGDTARARDQYALVHAWVSLARANGVDADLDTALAAADHGERGAALKAARAE 394
Cdd:COG0457   180 AAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLALRLAALALYQYR 244
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 91-463 3.44e-11

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 65.88  E-value: 3.44e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671  91 LLSGDDLAASIRGLQAHLRAQPRDAEAWSTLALAYVEQARTEgdpsrypQADKALDRALELRPHHDPALAGRAALAAARH 170
Cdd:TIGR02917 577 YLGKGQLKKALAILNEAADAAPDSPEAWLMLGRAQLAAGDLN-------KAVSSFKKLLALQPDSALALLLLADAYAVMK 649

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 171 DFRGALKYADEALSRNPYNERALCSRIDALVELGRYEEASKAADLADSRRPGVPV-FTRYAYVRELRGDTATAREVLTRA 249
Cdd:TIGR02917 650 NYAKAITSLKRALELKPDNTEAQIGLAQLLLAAKRTESAKKIAKSLQKQHPKAALgFELEGDLYLRQKDYPAAIQAYRKA 729

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 250 LGTAATRGDVAYVATALGQLawnqGQYRTALRHYARALAADDTYLPALEGRARTQAALGDRAAAITGMERVVARAplPQP 329
Cdd:TIGR02917 730 LKRAPSSQNAIKLHRALLAS----GNTAEAVKTLEAWLKTHPNDAVLRTALAELYLAQKDYDKAIKHYQTVVKKA--PDN 803

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 330 LVELGELyeerggkgdtarardqyalvhAWVSLARANgvdadldtaLAAADHGERGAALKAARAEwkrrhtvhTADALAW 409
Cdd:TIGR02917 804 AVVLNNL---------------------AWLYLELKD---------PRALEYAERALKLAPNIPA--------ILDTLGW 845

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2294385671 410 ALHVNGRDEEALPYARRATATGYRSASFRYHRGMIERAAGRPDRARASLTAALG 463
Cdd:TIGR02917 846 LLVEKGEADRALPLLRKAVNIAPEAAAIRYHLALALLATGRKAEARKELDKLLN 899
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 121-325 9.71e-11

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 64.24  E-value: 9.71e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 121 LALAYVEQARTEGDPSRYPQADKALDRALELRPHHDPALAGRAALAAARHDFRGALKYADEALSRNPYNERALCSRIDAL 200
Cdd:COG3914     9 LAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 201 VELGRYEEASKAADLADSRRPG-VPVFTRYAYVRELRGDTATAREVLTRALgtaATRGDVAYVATALGQLAWNQGQYRTA 279
Cdd:COG3914    89 QALGRYEEALALYRRALALNPDnAEALFNLGNLLLALGRLEEALAALRRAL---ALNPDFAEAYLNLGEALRRLGRLEEA 165

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 2294385671 280 LRHYARALAADDTYLPALEGRARTQAALGDRAAAITGMERVVARAP 325
Cdd:COG3914   166 IAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDP 211
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
91-324 1.30e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 61.56  E-value: 1.30e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671  91 LLSGDDLAASIRGLQAHLRAQPRDAEAWSTLALAYVEQARtegdpsrYPQADKALDRALELRPHHDPALAGRAALAAARH 170
Cdd:COG0457    18 YRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGR-------YEEALADYEQALELDPDDAEALNNLGLALQALG 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 171 DFRGALKYADEALSRNPYNERALCSRIDALVELGRYEEASKAADLADSRRPGVP-VFTRYAYVRELRGDTATAREVLTRA 249
Cdd:COG0457    91 RYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDAdALYNLGIALEKLGRYEEALELLEKL 170

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2294385671 250 LGTAATRGDVAYVATALGQLAWNQGQYRTALRHYARALAADDTYLPALEGRARTQAALGDRAAAITGMERVVARA 324
Cdd:COG0457   171 EAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLALRLAALALYQYRA 245
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 50-221 5.80e-10

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 61.55  E-value: 5.80e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671  50 RLHLVLSAGALAVALTTGALATGAARQATPAPASLPVTSPRLLSGDDLAAsIRGLQAHLRAQPRDAEAWSTLALAYVEQA 129
Cdd:COG3914    48 LAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQALGRYEEA-LALYRRALALNPDNAEALFNLGNLLLALG 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 130 RTEgdpsrypQADKALDRALELRPHHDPALAGRAALAAARHDFRGALKYADEALSRNPYNERALCSRIDALVELGRYEEA 209
Cdd:COG3914   127 RLE-------EALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEA 199

                         170
                  ....*....|..
gi 2294385671 210 SKAADLADSRRP 221
Cdd:COG3914   200 IAAYRRALELDP 211
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 96-250 1.77e-09

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 58.59  E-value: 1.77e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671  96 DLAASIRGLQAHLRAQPRDAEAWSTLALAYVEQartegdpSRYPQADKALDRALELRPHHDPALAGRAALAAARHDFRGA 175
Cdd:COG2956   125 DWEKAIEVLERLLKLGPENAHAYCELAELYLEQ-------GDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEA 197

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2294385671 176 LKYADEALSRNPYNERALCSRIDALVELGRYEEASKAADLADSRRPGVPVFTRYAYVRELRGDTATAREVLTRAL 250
Cdd:COG2956   198 IAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDLLLALADLLERKEGLEAALALLERQL 272
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 101-209 2.83e-09

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 55.01  E-value: 2.83e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 101 IRGLQAHLRAQPRDAEAWSTLALAYVEQartegdpSRYPQADKALDRALELRPHHDPALAGRAALAAARHDFRGALKYAD 180
Cdd:COG4235     3 IARLRQALAANPNDAEGWLLLGRAYLRL-------GRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLE 75

                          90       100
                  ....*....|....*....|....*....
gi 2294385671 181 EALSRNPYNERALCSRIDALVELGRYEEA 209
Cdd:COG4235    76 RALALDPDNPEALYLLGLAAFQQGDYAEA 104
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 235-467 5.82e-09

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 57.05  E-value: 5.82e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 235 LRGDTATAREVLTRALgtaATRGDVAYVATALGQLAWNQGQYRTALRHYARALAADDTYLPALEGRARTQAALGDRAAAI 314
Cdd:COG2956    20 LNGQPDKAIDLLEEAL---ELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAE 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 315 TGMERVVARAPL-PQPLVELGELYEERGgkgDTARARDQY--------ALVHAWVSLARAngvdadldtalaAADHGERG 385
Cdd:COG2956    97 ELLEKLLELDPDdAEALRLLAEIYEQEG---DWEKAIEVLerllklgpENAHAYCELAEL------------YLEQGDYD 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 386 AALKAA-RAEWKRRHTVHTADALAWALHVNGRDEEALPYARRATATGYRSASFRYHRGMIERAAGRPDRARASLTAALGL 464
Cdd:COG2956   162 EAIEALeKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALEL 241


                  ...
gi 2294385671 465 NPG 467
Cdd:COG2956   242 DPS 244
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 96-286 1.07e-07

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 54.23  E-value: 1.07e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671  96 DLAASIRGLQAHLRAQPRDAEAWSTLALAYVEQartegdpSRYPQADKALDRALELRPHHDPALAGRAALAAARHDFRGA 175
Cdd:COG3914    59 LLALAAGEAAAAAAALLLLAALLELAALLLQAL-------GRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEA 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 176 LKYADEALSRNPYNERALCSRIDALVELGRYEEASKAADLADSRRPGVP-VFTRYAYVRELRGDTATAREVLTRALGTAA 254
Cdd:COG3914   132 LAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAeALNNLGNALQDLGRLEEAIAAYRRALELDP 211

                         170       180       190
                  ....*....|....*....|....*....|....
gi 2294385671 255 TRGDVA--YVATALGQLAWNQGQYRTALRHYARA 286
Cdd:COG3914   212 DNADAHsnLLFALRQACDWEVYDRFEELLAALAR 245
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
258-462 4.23e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 51.16  E-value: 4.23e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 258 DVAYVATALGQLAWNQGQYRTALRHYARALAADDTYLPALEGRARTQAALGDRAAAITGMERVVARAP-LPQPLVELGEL 336
Cdd:COG0457     6 DDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPdDAEALNNLGLA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 337 YEERGgkgDTARARDQYalvhawvslarangvdadldtalaaadhgERGAALKAARAEwkrrhtvhTADALAWALHVNGR 416
Cdd:COG0457    86 LQALG---RYEEALEDY-----------------------------DKALELDPDDAE--------ALYNLGLALLELGR 125

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 2294385671 417 DEEALPYARRATATGYRSASFRYHRGMIERAAGRPDRARASLTAAL 462
Cdd:COG0457   126 YDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLE 171
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 122-250 4.70e-07

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 49.03  E-value: 4.70e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 122 ALAYVEQARTEGDPSRYPQADKALDRALELRPHHDPALAGRAALAAARHDFRGALKYADEALSRNPYNERALCSRIDALV 201
Cdd:COG4783     4 AEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALL 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2294385671 202 ELGRYEEASKAADLADSRRPGVP-VFTRYAYVRELRGDTATAREVLTRAL 250
Cdd:COG4783    84 KAGDYDEALALLEKALKLDPEHPeAYLRLARAYRALGRPDEAIAALEKAL 133
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 171-290 6.33e-07

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 48.65  E-value: 6.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 171 DFRGALKYADEALSRNPYNERALCSRIDALVELGRYEEASKAADLADSRRPGVP-VFTRYAYVRELRGDTATAREVLTRA 249
Cdd:COG4783    19 DYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPeARLNLGLALLKAGDYDEALALLEKA 98

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2294385671 250 LgtaATRGDVAYVATALGQLAWNQGQYRTALRHYARALAAD 290
Cdd:COG4783    99 L---KLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELD 136
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 95-221 1.04e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 47.88  E-value: 1.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671  95 DDLAASIRGLQAHLRAQPRDAEAWSTLALAYVEQARtegdpsrYPQADKALDRALELRPHHDPALAGRAALAAARHDFRG 174
Cdd:COG4783    18 GDYDEAEALLEKALELDPDNPEAFALLGEILLQLGD-------LDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDE 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2294385671 175 ALKYADEALSRNPYNERALCSRIDALVELGRYEEASKAADLADSRRP 221
Cdd:COG4783    91 ALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDP 137
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 199-325 1.15e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 47.88  E-value: 1.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 199 ALVELGRYEEASKAADLADSRRPG-VPVFTRYAYVRELRGDTATAREVLTRALgtaATRGDVAYVATALGQLAWNQGQYR 277
Cdd:COG4783    13 ALLLAGDYDEAEALLEKALELDPDnPEAFALLGEILLQLGDLDEAIVLLHEAL---ELDPDEPEARLNLGLALLKAGDYD 89

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2294385671 278 TALRHYARALAADDTYLPALEGRARTQAALGDRAAAITGMERVVARAP 325
Cdd:COG4783    90 EALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDP 137
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
183-456 1.82e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 49.23  E-value: 1.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 183 LSRNPYNERALCSRIDALVELGRYEEASKAADLADSRRPGVP-VFTRYAYVRELRGDTATAREVLTRALgtaATRGDVAY 261
Cdd:COG0457     1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAeALYNLGLAYLRLGRYEEALADYEQAL---ELDPDDAE 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 262 VATALGQLAWNQGQYRTALRHYARALAADDTYLPALEGRARTQAALGDRAAAITGMERVVARAPlpqplvelgelyeerg 341
Cdd:COG0457    78 ALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDP---------------- 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 342 gkgdtarardqyALVHAWVSLARANGVDADLDTALAAADHGERGAALKAARAEWKRRHTVHTADALAWALHVNGRDEEAL 421
Cdd:COG0457   142 ------------DDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRK 209

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 2294385671 422 PYARRATATGYRSASFRYHRGMIERAAGRPDRARA 456
Cdd:COG0457   210 KLAILTLAALAELLLLALALLLALRLAALALYQYR 244
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
57-288 3.31e-06

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 47.99  E-value: 3.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671  57 AGALAVALTTGALATGAARQATPAPASLPVTSPRLLSGDD---LAASIRGLQAHLRAQPRDAEAWSTLALAYVEQARTEG 133
Cdd:COG4785     5 ALALLLALALAAAAASKAAILLAALLFAAVLALAIALADLalaLAAAALAAAALAAERIDRALALPDLAQLYYERGVAYD 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 134 DPSRYPQADKALDRALELRPHHDPALAGRAALAAARHDFRGALKYADEALSRNPYNERALCSRIDALVELGRYEEASKAA 213
Cdd:COG4785    85 SLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLGRYELAIADL 164

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2294385671 214 DLADSRRPGVPVFTRYAYVRELRGDTATAREVLTRALGTAATrgdvayvatalgqlawNQGQYRTALRHYARALA 288
Cdd:COG4785   165 EKALELDPNDPERALWLYLAERKLDPEKALALLLEDWATAYL----------------LQGDTEEARELFKLALA 223
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 300-468 2.91e-05

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 46.52  E-value: 2.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 300 RARTQAALGDRAAAITGMERVVARAPLPQPLVELGELYEERGGKGDTARARDQYALVHAWVSLARANGVDADLDTALAAA 379
Cdd:COG3914     7 LALAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAAL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 380 DHGERGAALKAARA-EWKRRHTVHTADA---LAWALHVNGRDEEALPYARRATATGYRSASFRYHRGMIERAAGRPDRAR 455
Cdd:COG3914    87 LLQALGRYEEALALyRRALALNPDNAEAlfnLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAI 166

                         170
                  ....*....|...
gi 2294385671 456 ASLTAALGLNPGF 468
Cdd:COG3914   167 AALRRALELDPDN 179
PRK11788 PRK11788
tetratricopeptide repeat protein; Provisional
 236-342 7.48e-05

tetratricopeptide repeat protein; Provisional


Pssm-ID: 236983 [Multi-domain]  Cd Length: 389  Bit Score: 44.80  E-value: 7.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 236 RGDTATAREVLTRALgtAATRGDV-AYVAtaLGQLAWNQGQYRTALRHYARALAADDTYLP-ALEGRARTQAALGDRAAA 313
Cdd:PRK11788  193 RGDLDAARALLKKAL--AADPQCVrASIL--LGDLALAQGDYAAAIEALERVEEQDPEYLSeVLPKLMECYQALGDEAEG 268

                          90       100
                  ....*....|....*....|....*....
gi 2294385671 314 ITGMERVVARAPLPQPLVELGELYEERGG 342
Cdd:PRK11788  269 LEFLRRALEEYPGADLLLALAQLLEEQEG 297
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
232-325 7.77e-05

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 41.69  E-value: 7.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 232 VRELRGDTATAREVLTRALgtaATRGDVAYVATALGQLAWNQGQYRTALRhYARALAADDTYLPALEGRARTQAALGDRA 311
Cdd:COG3063     1 LYLKLGDLEEAEEYYEKAL---ELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGDYD 76

                          90
                  ....*....|....
gi 2294385671 312 AAITGMERVVARAP 325
Cdd:COG3063    77 EALAYLERALELDP 90
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
170-250 1.23e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 40.92  E-value: 1.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 170 HDFRGALKYADEALSRNPYNERALCSRIDALVELGRYEEASKAADLADSRRPGVPVFTRYAYVRELRGDTATAREVLTRA 249
Cdd:COG3063     6 GDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIALEKALKLDPNNAEALLNLAELLLELGDYDEALAYLERA 85


                  .
gi 2294385671 250 L 250
Cdd:COG3063    86 L 86
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 260-341 1.28e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 42.10  E-value: 1.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 260 AYVATALGQLAWNQGQYRTALRHYARALAADDTYLPALEGRARTQAALGDRAAAITGMERVVARAP-LPQPLVELGELYE 338
Cdd:COG4783     4 AEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPdEPEARLNLGLALL 83


                  ...
gi 2294385671 339 ERG 341
Cdd:COG4783    84 KAG 86
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 266-353 1.39e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 41.53  E-value: 1.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 266 LGQLAWNQGQYRTALRHYARALAADDTYLPALEGRARTQAALGDRAAAITGMERVVARAPL-PQPLVELGELYEERggkG 344
Cdd:COG4235    23 LGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDnPEALYLLGLAAFQQ---G 99


                  ....*....
gi 2294385671 345 DTARARDQY 353
Cdd:COG4235   100 DYAEAIAAW 108
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 253-468 1.95e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 43.83  E-value: 1.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 253 AATRGDVAYVATALGQLAWNQGQYRTALRHYARALAADDTYLPALEGRARTQAALGDRAAAITGMERVVARAP-LPQPLV 331
Cdd:COG3914    37 LAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRALALNPdNAEALF 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 332 ELGELYEERGgkgDTARARDQYalvhawvslarangvdadldtalaaadhgERGAALKAARAEWKRRhtvhtadaLAWAL 411
Cdd:COG3914   117 NLGNLLLALG---RLEEALAAL-----------------------------RRALALNPDFAEAYLN--------LGEAL 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2294385671 412 HVNGRDEEALPYARRATATGYRSASFRYHRGMIERAAGRPDRARASLTAALGLNPGF 468
Cdd:COG3914   157 RRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDN 213
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 236-325 2.89e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 40.76  E-value: 2.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 236 RGDTATAREVLTRALgtaATRGDVAYVATALGQLAWNQGQYRTALRHYARALAADDTYLPALEGRARTQAALGDRAAAIT 315
Cdd:COG4235    30 LGRYDEALAAYEKAL---RLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQGDYAEAIA 106

                          90
                  ....*....|
gi 2294385671 316 GMERVVARAP 325
Cdd:COG4235   107 AWQKLLALLP 116
COG4700 COG4700
Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];
204-354 7.80e-04

Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];


Pssm-ID: 443735 [Multi-domain]  Cd Length: 249  Bit Score: 41.02  E-value: 7.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 204 GRYEEASKAADLADSrrpgvpVFTRYAYVRELR--GDTATAREVLTRALgTAATRGDVaYVATALGQLAWNQGQYRTALR 281
Cdd:COG4700    74 RELRELEKALEFADT------VQNRVRLADALLelGRYDEAIELYEEAL-TGIFADDP-HILLGLAQALFELGRYAEALE 145

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2294385671 282 HYARALAADDTYLP--ALEGRARTQAALGDRAAAITGMERVVARAPLPQPLVELGELYEERggkGDTARARDQYA 354
Cdd:COG4700   146 TLEKLIAKNPDFKSsdAHLLYARALEALGDLEAAEAELEALARRYSGPEARYRYAKFLARQ---GRTAEAKELLE 217
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 236-325 8.27e-04

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 39.20  E-value: 8.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 236 RGDTATAREVLTRALGTAATRGDVAYVATALGQLAWNQGQYRTALRHYARALAA--DDTYLP-ALEGRARTQAALGDRAA 312
Cdd:COG1729     6 AGDYDEAIAAFKAFLKRYPNSPLAPDALYWLGEAYYALGDYDEAAEAFEKLLKRypDSPKAPdALLKLGLSYLELGDYDK 85

                          90
                  ....*....|...
gi 2294385671 313 AITGMERVVARAP 325
Cdd:COG1729    86 ARATLEELIKKYP 98
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 173-326 1.15e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 39.56  E-value: 1.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 173 RGALKYADEALSRNPYNERALCSRIDALVELGRYEEASKAADLADSRRPGVPVFTRYAYVRELRGDTATAREVLTRALgt 252
Cdd:COG5010     4 LEGFDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQAL-- 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2294385671 253 aATRGDVAYVATALGQLAWNQGQYRTALRHYARALAADDTYLPALEGRARTQAALGDRAAAITGMERVVARAPL 326
Cdd:COG5010    82 -QLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSPL 154
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
137-221 2.27e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 37.46  E-value: 2.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 137 RYPQADKALDRALELRPHHDPALAGRAALAAARHDFRGALKYaDEALSRNPYNERALCSRIDALVELGRYEEASKAADLA 216
Cdd:COG3063     7 DLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIAL-EKALKLDPNNAEALLNLAELLLELGDYDEALAYLERA 85


                  ....*
gi 2294385671 217 DSRRP 221
Cdd:COG3063    86 LELDP 90
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
269-353 2.32e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 37.46  E-value: 2.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 269 LAWNQGQYRTALRHYARALAADDTYLPALEGRARTQAALGDRAAAITgMERVVARAP-LPQPLVELGELYEERggkGDTA 347
Cdd:COG3063     1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPnNAEALLNLAELLLEL---GDYD 76


                  ....*.
gi 2294385671 348 RARDQY 353
Cdd:COG3063    77 EALAYL 82
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
96-187 5.86e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 36.30  E-value: 5.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671  96 DLAASIRGLQAHLRAQPRDAEAWSTLALAYVEQARtegdpsrYPQAdKALDRALELRPHHDPALAGRAALAAARHDFRGA 175
Cdd:COG3063     7 DLEEAEEYYEKALELDPDNADALNNLGLLLLEQGR-------YDEA-IALEKALKLDPNNAEALLNLAELLLELGDYDEA 78

                          90
                  ....*....|..
gi 2294385671 176 LKYADEALSRNP 187
Cdd:COG3063    79 LAYLERALELDP 90
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 73-221 6.58e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 37.25  E-value: 6.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671  73 AARQATPAPASLPVTSPRLLSGDDLAASIRGLQAHLRAQPRDAEAWSTLALAYVEQARTEGDPSRYPQADKALDRALELR 152
Cdd:COG5010     5 EGFDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLD 84

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2294385671 153 PHHDPALAGRAALAAARHDFRGALKYADEALSRNPYNERALCSRIDALVELGRYEEASKAADLADSRRP 221
Cdd:COG5010    85 PNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
199-294 6.72e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 35.92  E-value: 6.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294385671 199 ALVELGRYEEASKAADLADSRRPGVP-VFTRYAYVRELRGDTATAREvLTRALGTAATRGDVAYvatALGQLAWNQGQYR 277
Cdd:COG3063     1 LYLKLGDLEEAEEYYEKALELDPDNAdALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALL---NLAELLLELGDYD 76

                          90
                  ....*....|....*..
gi 2294385671 278 TALRHYARALAADDTYL 294
Cdd:COG3063    77 EALAYLERALELDPSAL 93
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
407-468 8.51e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 38.06  E-value: 8.51e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2294385671 407 LAWALHVNGRDEEALPYARRATATGYRSASFRYHRGMIERAAGRPDRARASLTAALGLNPGF 468
Cdd:COG0457    14 LGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDD 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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