|
Name |
Accession |
Description |
Interval |
E-value |
| umuC |
PRK03609 |
translesion error-prone DNA polymerase V subunit UmuC; |
1-420 |
0e+00 |
|
translesion error-prone DNA polymerase V subunit UmuC;
Pssm-ID: 179607 [Multi-domain] Cd Length: 422 Bit Score: 854.45 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 1 MFALADVNSFYASCERVFRPDLKGKPVVVLSNNDGCIIARSAEAKPW-IKMGTPWFQMKNERYPEKIYAFSSNYELYASM 79
Cdd:PRK03609 1 MFALCDVNSFYASCETVFRPDLRGKPVVVLSNNDGCVIARSAEAKALgIKMGDPWFKQKDLFRRCGVVCFSSNYELYADM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 80 SARVMSCLEELAPRVEQYSIDEMFLDLTGVEHCMDLEDFGRQLRQHVYDCTRLTIGVGAGPTKTLAKSAQWASKEW-KQF 158
Cdd:PRK03609 81 SNRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFGREIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKWqRQT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 159 RGVLALTrgNPQRTRKLLSLQPVEDIWGVGNRIARKLHVLGIRTALDLALTNPAFIRKNFSVVLERTVRELNGESCMSLE 238
Cdd:PRK03609 161 GGVVDLS--NLERQRKLLSLQPVEEVWGVGRRISKKLNAMGIKTALDLADTNIRFIRKHFNVVLERTVRELRGEPCLSLE 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 239 EAPPTKQQIVCSRSFGEKVTEYDSLRQAVCQYAERASEKLRKERQYCRHISVFIKTSPFAVKEPYYGNVATEKLLTPTQD 318
Cdd:PRK03609 239 EFAPTKQEIVCSRSFGERITDYESMRQAICSYAARAAEKLRGEHQYCRFISTFVKTSPFALNEPYYGNSASVKLLTPTQD 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 319 TRDIIAAATTALERIWKDGHRYAKAGVMLNDFTGSGVSQLQLFDERPPRPHSAELMKVLDGIN-HSGLGQVWFAGRGIAP 397
Cdd:PRK03609 319 SRDIIAAATRALDAIWRDGHRYQKAGVMLGDFFSQGVAQLNLFDDNAPRPGSEQLMKVLDTLNaKSGKGTLYFAGQGIAQ 398
|
410 420
....*....|....*....|...
gi 2295969074 398 AWQMKRDMLSPAYTTRWKDIPIA 420
Cdd:PRK03609 399 QWQMKREMLSPRYTTRWSDLLRV 421
|
|
| PolY_Pol_V_umuC |
cd01700 |
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion ... |
3-349 |
7.05e-180 |
|
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion synthesis (TLS) polymerase that consists of the heterotrimer of one umuC and two umuD subunits. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol V, RecA, single stranded DNA-binding protein, beta sliding clamp, and gamma clamp loading complex are responsible for inducing the SOS response in bacteria to repair UV-induced DNA damage.
Pssm-ID: 176454 [Multi-domain] Cd Length: 344 Bit Score: 504.77 E-value: 7.05e-180
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 3 ALADVNSFYASCERVFRPDLKGKPVVVLSNNDGCIIARSAEAKP-WIKMGTPWFQMKnERYPE-KIYAFSSNYELYASMS 80
Cdd:cd01700 1 ALVDCNSFYASCERVFRPLLLGRPLVVLSNNDGCVIARSPEAKAlGIKMGSPYFKVP-DLLERhGVAVFSSNYALYGDMS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 81 ARVMSCLEELAPRVEQYSIDEMFLDLTGVEHCMDLEDFGRQLRQHVYDCTRLTIGVGAGPTKTLAKSAQWASKEWKQFRG 160
Cdd:cd01700 80 RRIMSILERFSPDVEVYSIDESFLDLTGSLRFGDLEELARKIRRRILQETGIPVTVGIGPTKTLAKLANDLAKKKNPYGG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 161 VLALTRgnPQRTRKLLSLQPVEDIWGVGNRIARKLHVLGIRTALDLALTNPAFIRKNFSVVLERTVRELNGESCMSLEEA 240
Cdd:cd01700 160 VVDLTD--EEVRDKLLKILPVGDVWGIGRRTAKKLNAMGIHTAGDLAQADPDLLRKKFGVVGERLVRELNGIDCLPLEEY 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 241 PPTKQQIVCSRSFGEKVTEYDSLRQAVCQYAERASEKLRKERQYCRHISVFIKTSPFAVKEPYYGnvATEKLLTPTQDTR 320
Cdd:cd01700 238 PPPKKSIGSSRSFGRDVTDLDELKQALAEYAERAAEKLRRQKSVARTISVFIGTSGFSRQPKYYS--ATNTLPYPTNDTR 315
|
330 340
....*....|....*....|....*....
gi 2295969074 321 DIIAAATTALERIWKDGHRYAKAGVMLND 349
Cdd:cd01700 316 EIVKAALRLLYAIYRPGYAYRKAGVMLSD 344
|
|
| DinP |
COG0389 |
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ... |
1-347 |
6.41e-128 |
|
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];
Pssm-ID: 440158 [Multi-domain] Cd Length: 336 Bit Score: 372.55 E-value: 6.41e-128
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 1 MFALADVNSFYASCERVFRPDLKGKPVVVLS-NNDGCIIARSAEAKPW-IKMGTPWFQMKnERYPEKIYaFSSNYELYAS 78
Cdd:COG0389 2 RILHVDMDAFYASVEQRDRPELRGKPVAVGGdNNRGVVAAASYEARAFgVRSGMPLFQAR-RLCPDLVV-LPPDFELYRD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 79 MSARVMSCLEELAPRVEQYSIDEMFLDLTGVEHCM-DLEDFGRQLRQHVYDCTRLTIGVGAGPTKTLAKSAQWASKEwkq 157
Cdd:COG0389 80 VSRRVMAILERYTPLVEPLSIDEAFLDVTGSARLFgSAEAIARRIRRRIRRETGLTVSVGIAPNKFLAKIASDLAKP--- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 158 fRGVLALTrgnPQRTRKLLSLQPVEDIWGVGNRIARKLHVLGIRTALDLALTNPAFIRKNFSVVLERTVRELNGESCMSL 237
Cdd:COG0389 157 -DGLTVIP---PGEVAAFLAPLPVEKLWGVGPKTAEKLARLGIRTIGDLAALPRAELRRRFGKVGERLYRLARGIDPRPV 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 238 EEAPPtKQQIVCSRSFGEKVTEYDSLRQAVCQYAERASEKLRKERQYCRHISVFIKTSPFAVkepyygNVATEKLLTPTQ 317
Cdd:COG0389 233 EPRRP-RKSIGVERTFGEDLTDLEELEAALRRLAERLAERLRRQGLGARTVTVKLRTSDFRT------TTRSRTLPEPTD 305
|
330 340 350
....*....|....*....|....*....|
gi 2295969074 318 DTRDIIAAATTALERIWKDGHRYAKAGVML 347
Cdd:COG0389 306 DTAELLRAARELLERIYRPGRPVRLLGVRL 335
|
|
| PolY_Pol_IV_kappa |
cd03586 |
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ... |
6-336 |
4.35e-60 |
|
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.
Pssm-ID: 176459 [Multi-domain] Cd Length: 334 Bit Score: 198.51 E-value: 4.35e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 6 DVNSFYASCERVFRPDLKGKPVVVLSNNDGCIIArSA--EAKPW-IKMGTPWFQMKnERYPEKIYAfSSNYELYASMSAR 82
Cdd:cd03586 4 DMDAFYASVEQRDNPELKGKPVAVGGSSDRGVVS-TAsyEARKFgVRSAMPIFQAK-KLCPNLIFV-PPRFDKYREVSRQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 83 VMSCLEELAPRVEQYSIDEMFLDLTGVEHC-MDLEDFGRQLRQHVYDCTRLTIGVGAGPTKTLAKSAQwaskEWKQFRGV 161
Cdd:cd03586 81 IMEILREYTPLVEPLSIDEAYLDVTDYVRLfGSATEIAKEIRARIREETGLTASAGIAPNKFLAKIAS----DLNKPNGL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 162 LALTrgnPQRTRKLLSLQPVEDIWGVGNRIARKLHVLGIRTALDLALTNPAFIRKNFSVVLERTVRELNGESCMSLEEAP 241
Cdd:cd03586 157 TVIP---PEDVEEFLAPLPVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFGKSGRRLYELARGIDNRPVEPDR 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 242 PTKqQIVCSRSFGEKVTEYDSLRQAVCQYAERASEKLRKERQYCRHISVFIKTSPFAVKepyygnVATEKLLTPTQDTRD 321
Cdd:cd03586 234 ERK-SIGVERTFSEDLTDPEELLEELLELAEELAERLRKRGLKGRTVTVKLKYADFSTR------TRSRTLPEPTDDAED 306
|
330
....*....|....*
gi 2295969074 322 IIAAATTALERIWKD 336
Cdd:cd03586 307 IYELALELLEELLDG 321
|
|
| PolY |
cd00424 |
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases ... |
6-347 |
3.19e-50 |
|
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Most TLS polymerases are members of the Y-family, including Pol eta, Pol kappa/IV, Pol iota, Rev1, and Pol V, which is found exclusively in bacteria. In eukaryotes, the B-family polymerase Pol zeta also functions as a TLS polymerase. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176453 [Multi-domain] Cd Length: 343 Bit Score: 172.93 E-value: 3.19e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 6 DVNSFYASCERVFRPDLKGKPVVVLSNND--GCIIARSAEAKPW-IKMGTPWFQMKnERYPEKIYaFSSNYELYASMSAR 82
Cdd:cd00424 4 DFDNFFASVEQLARPELKGRPVVVVPFNSdsTCVIACSYEARKYgVKRGMPVREAR-KMCPNLIL-VPARLDLYRRLSER 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 83 VMSCLEELAPRVEQYSIDEMFLDLTGVEHCM-DLEDFGRQLRQHVYDCTR-LTIGVGAGPTKTLAKSAQWASKewkqfRG 160
Cdd:cd00424 82 LLSELEEVAPLVEVASIDELFLDLTGSARLLgLGSEVALRIKRHIAEQLGgITASIGIASNKLLAKLAAKYAK-----PD 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 161 VLALTRGNPQrTRKLLSLqPVEDIWGVGNRIARKLHVLGIRTALDLALTNP-AFIRKNFSVVLERTVRELNGESCMSLEE 239
Cdd:cd00424 157 GLTILDPEDL-PGFLSKL-PLTDLPGIGAVTAKRLEAVGINPIGDLLAASPdALLALWGGVSGERLWYALRGIDDEPLSP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 240 APPtKQQIVCSRSFGEKVTEYDSLRQAVCQYAERASEKLRKERQYCRHISVFIKTSPFAVKEPYYGNVATEKLLTPTQDt 319
Cdd:cd00424 235 PRP-RKSFSHERVLPRDSRNAEDARPLLRLLLEKLARRLRRDGRGATRLRLWLRTVDGRWSGHADIPSRSAPRPISTED- 312
|
330 340
....*....|....*....|....*...
gi 2295969074 320 RDIIAAATTALERIWKDGHRYAKAGVML 347
Cdd:cd00424 313 GELLHALDKLWRALLDDKGPRRLRRLGV 340
|
|
| PRK03103 |
PRK03103 |
DNA polymerase IV; Reviewed |
4-382 |
5.39e-44 |
|
DNA polymerase IV; Reviewed
Pssm-ID: 235104 [Multi-domain] Cd Length: 409 Bit Score: 158.24 E-value: 5.39e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 4 LADVNSFYASCERVFRPDLKGKPVVVL---SNNDGCIIARSAEAKPW-IKMGTPWFQMKnERYPEkIYAFSSNYELYASM 79
Cdd:PRK03103 7 LVDMQSFYASVEKAANPELKGRPVIVSgdpERRSGVVLAACPLAKAYgVKTAERLWEAQ-QKCPD-LVVVKPRMQRYIDV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 80 SARVMSCLEELAPRVEQYSIDEMFLDLTGVEHCM-DLEDFGRQLRQHVYDCTRLTIGVGAGPTKTLAKSA--QWASKEWK 156
Cdd:PRK03103 85 SLQITRILEDFTDLVEPFSIDEQFLDVTGSQKLFgSPLEIAQKIQQRIMRETGVYARVGIGPNKLLAKMAcdNFAKKNPD 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 157 qfrGVLALTRGNPQrtRKLLSLqPVEDIWGVGNRIARKLHVLGIRTALDLALTNPAFIRKNFSVVLERTVRELNGescms 236
Cdd:PRK03103 165 ---GLFTLDKEDVP--ADLWPL-PVRKLFGVGSRMEKHLRRMGIRTIGQLANTPLERLKKRWGINGEVLWRTANG----- 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 237 LEEAPPTKQQIVCSRSFGEKVT------EYDSLRQAVCQYAERASEKLRKERQYCRHISVFIKTSPFAVKEPYYGNVate 310
Cdd:PRK03103 234 IDYSPVTPHSLDRQKAIGHQMTlprdyrGFEEIKVVLLELCEEVCRRARAKGYMGRTVSVSLRGADFDWPTGFSRQM--- 310
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2295969074 311 KLLTPTQDTRDIIAAATTALERIWkDGHRYAKAGVMLNDFTGSGVSQLQLFDERPPRphsAELMKVLDGINH 382
Cdd:PRK03103 311 TLPEPTNLAMEVYEAACKLFHRHW-DGKPVRRVGVTLSNLVSDDVWQLSLFGDRERK---RSLGYVMDDIKN 378
|
|
| IMS |
pfam00817 |
impB/mucB/samB family; These proteins are involved in UV protection (Swiss). |
6-148 |
1.02e-42 |
|
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
Pssm-ID: 425885 [Multi-domain] Cd Length: 148 Bit Score: 146.95 E-value: 1.02e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 6 DVNSFYASCERVFRPDLKGKPVVVLSNN-DGCIIARSAEAKPW-IKMGTPWFQMKnERYPEkIYAFSSNYELYASMSARV 83
Cdd:pfam00817 2 DMDAFFASVELLRDPELKGKPVAVGGGNgRGIVAAASYEARKYgVRSGMPVFEAK-KLCPN-LIVVPPDLELYRRASRKI 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2295969074 84 MSCLEEL-APRVEQYSIDEMFLDLTGVEHCMDLE-DFGRQLRQHVYDCTRLTIGVGAGPTKTLAKSA 148
Cdd:pfam00817 80 FEILRRFsTPKVEQASIDEAFLDLTGLEKLFGAEeALAKRLRREIAEETGLTCSIGIAPNKLLAKLA 146
|
|
| PRK01810 |
PRK01810 |
DNA polymerase IV; Validated |
6-381 |
1.18e-37 |
|
DNA polymerase IV; Validated
Pssm-ID: 179337 [Multi-domain] Cd Length: 407 Bit Score: 140.94 E-value: 1.18e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 6 DVNSFYASCERVFRPDLKGKPVVVLSN---NDGCIIARSAEAKPW-IKMGTPWFQMKnERYPEKIyAFSSNYELYASMSA 81
Cdd:PRK01810 11 DMNSFFASVEIAYDPSLQGKPLAVAGNekeRKGIIVTCSYEARAYgIRTTMPLWEAK-RLCPQLI-VRRPNFDRYREASR 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 82 RVMSCLEELAPRVEQYSIDEMFLDLTGVEHCMDLEDFGRQLRQHVYDCTRLTIGVGAGPTKTLAKSAQwaskEWKQFRGV 161
Cdd:PRK01810 89 QMFQILSEFTPLVQPVSIDEGYLDITDCYALGSPLEIAKMIQQRLLTELQLPCSIGIAPNKFLAKMAS----DMKKPLGI 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 162 LAL-TRGNPqrtRKLLSLqPVEDIWGVGNRIARKLHVLGIRTALDLALTNPAFIRKNFSVVLERTVRELNGEscmslEEA 240
Cdd:PRK01810 165 TVLrKRDVP---EMLWPL-PVGEMHGIGEKTAEKLKDIGIQTIGDLAKADEHILRAKLGINGVRLQRRANGI-----DDR 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 241 PPTKQQIVCSRSFG------EKVTEYDSLRQAVCQYAERASEKLRKERQYCRHISVFIKTSPFAvkepyygNVA-TEKLL 313
Cdd:PRK01810 236 PVDPEAIYQFKSVGnsttlsHDMDEEKELLDVLRRLSKSVSKRLQKKTVVSYNVQIMIRYHDRR-------TITrSKTLK 308
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2295969074 314 TPTQDTRDIIAAATTALERIWkDGHRYAKAGVMLNDFTG--SGVSQLQLFD------ERPprphsaeLMKVLDGIN 381
Cdd:PRK01810 309 NPIWEKRDIFQAASRLFKQHW-NGDPVRLLGVTATDLEWktEAVKQLDLFSfeedakEEP-------LLAVIDQIN 376
|
|
| PRK03352 |
PRK03352 |
DNA polymerase IV; Validated |
6-333 |
1.59e-33 |
|
DNA polymerase IV; Validated
Pssm-ID: 179564 [Multi-domain] Cd Length: 346 Bit Score: 128.60 E-value: 1.59e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 6 DVNSFYASCERVFRPDLKGKPVVVLSNND-----GCIIARSAEAKPW-IKMGTPwFQMKNERYPEKIYaFSSNYELYASM 79
Cdd:PRK03352 11 DLDQFIAAVELLRRPELAGLPVIVGGNGDpteprKVVTCASYEARAFgVRAGMP-LRTAARRCPDAVF-LPSDPAAYDAA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 80 SARVMSCLEELAPRVEQYSIDEMFLdltGVEhCMDLEDFGRQLRQHVYDCTRLTIGVGAGPTKTLAKSAQWASKEwkqfR 159
Cdd:PRK03352 89 SEEVMATLRDLGVPVEVWGWDEAFL---GVD-TDDPEALAEEIRAAVLERTGLSCSVGIGDNKLRAKIATGFAKP----A 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 160 GVLALTRGNpqrTRKLLSLQPVEDIWGVGNRIARKLHVLGIRTALDLALTNPAFIRKNFS-------VVLERTVrelnGE 232
Cdd:PRK03352 161 GVFRLTDAN---WMAVMGDRPTDALWGVGPKTAKRLAALGITTVADLAAADPAELAATFGpttgpwlLLLARGG----GD 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 233 SCMSLEEAPPTkqqivcSRS----FGEKVTEYDSLRQAVCQYAERASEKLRKERQYCRHISVFIKTSPFavkepyYGNVA 308
Cdd:PRK03352 234 TEVSAEPWVPR------SRSrevtFPQDLTDRAEVESAVRELARRVLDEVVAEGRPVTRVAVKVRTATF------YTRTK 301
|
330 340
....*....|....*....|....*
gi 2295969074 309 TEKLLTPTQDTRDIIAAATTALERI 333
Cdd:PRK03352 302 IRKLPEPTTDPDVIEAAALDVLDRF 326
|
|
| PRK14133 |
PRK14133 |
DNA polymerase IV; Provisional |
6-299 |
2.84e-29 |
|
DNA polymerase IV; Provisional
Pssm-ID: 184529 [Multi-domain] Cd Length: 347 Bit Score: 116.74 E-value: 2.84e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 6 DVNSFYASCERVFRPDLKGKPVVV--LSNNdGCIIARSAEAKPW-IKMGTPWFqMKNERYPEKIYaFSSNYELYASMSAR 82
Cdd:PRK14133 9 DMDAFFASVEQMDNPKLKGKPVIVggISER-GVVSTCSYEARKYgVHSAMPVF-MAKKRCPHGIF-LPVRHERYKEVSKN 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 83 VMSCLEELAPRVEQYSIDEMFLDLTGVEHcmDLEDFGRQLRQHVYDCTRLTIGVGAGPTKTLAKSAQwaskEWKQFRGVL 162
Cdd:PRK14133 86 IFKILYEVTPIVEPVSIDEAYLDITNIKE--EPIKIAKYIKKKVKKETGLTLSVGISYNKFLAKLAS----DWNKPDGIK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 163 ALTRgnpQRTRKLLSLQPVEDIWGVGNRIARKLHVLGIRTALDL-ALTNPAFIR---KNFSVVLERtVRELNGESCMSLE 238
Cdd:PRK14133 160 IITE---DMIPDILKPLPISKVHGIGKKSVEKLNNIGIYTIEDLlKLSREFLIEyfgKFGVEIYER-IRGIDYREVEVSR 235
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2295969074 239 EapptKQQIVCSRSFGEKVTEYDSLRQAVCQYAERASEKLRKERQYCRHISVFIKTSPFAV 299
Cdd:PRK14133 236 E----RKSIGKETTLKKDTKDKEELKKYLKDFSNIISEELKKRNLYGKTVTVKIKTSDFQT 292
|
|
| PRK03348 |
PRK03348 |
DNA polymerase IV; Provisional |
6-326 |
1.03e-27 |
|
DNA polymerase IV; Provisional
Pssm-ID: 235118 [Multi-domain] Cd Length: 454 Bit Score: 114.26 E-value: 1.03e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 6 DVNSFYASCERVFRPDLKGKPVVV--LSNNdGCIIARSAEAKpwiKMGT----PWFQMKnERYPEKIYAFSSNYELYASM 79
Cdd:PRK03348 11 DMDAFFASVEQLTRPTLRGRPVLVggLGGR-GVVAGASYEAR---VFGArsamPMHQAR-RLVGNGAVVLPPRFVVYRAA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 80 SARVMSCLEELAPRVEQYSIDEMFLD---LTGVEhCMDLEDFGRQLRQHVYDCTRLTIGVGAGPTKTLAKSAQWASKEwk 156
Cdd:PRK03348 86 SRRVFDTLRELSPVVEQLSFDEAFVEpaeLAGAS-AEEVEAFAERLRARVREETGLPASVGAGSGKQIAKIASGLAKP-- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 157 qfRGVLALTrgnPQRTRKLLSLQPVEDIWGVGNRIARKLHVLGIRTALDLAltnpAFIRKNFSVVLERTVrelnGESCMS 236
Cdd:PRK03348 163 --DGIRVVP---PGEERELLAPLPVRRLWGIGPVTEEKLHRLGIETIGDLA----ALSEAEVANLLGATV----GPALHR 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 237 L---------EEAPPTKqQIVCSRSFGEKVTEYDSLRQAVCQYAERASEKLRKERQYCRHISVFIKTSPFAVKepyygnV 307
Cdd:PRK03348 230 LargiddrpvAERAEAK-QISAESTFAVDLTTRAQLREAIERIAEHAHRRLLKDGRGARTVTVKLRKSDFSTL------T 302
|
330
....*....|....*....
gi 2295969074 308 ATEKLLTPTQDTRDIIAAA 326
Cdd:PRK03348 303 RSATLPYATDDAAVLAATA 321
|
|
| IMS_C |
pfam11799 |
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss). |
244-351 |
1.24e-25 |
|
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss).
Pssm-ID: 463354 [Multi-domain] Cd Length: 104 Bit Score: 99.94 E-value: 1.24e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 244 KQQIVCSRSFGEKVTEYDSLRQAVCQYAERASEKLRKERQYCRHISVFIKTSPFAvkepyyGNVATEKLLTPTQDTRDII 323
Cdd:pfam11799 1 RKSIGAERTFGRDLTDLEELREALLELAEELAERLRRQGLVARTVTVKIRYSDFR------TITRSVTLPSPTDDTDEIY 74
|
90 100
....*....|....*....|....*...
gi 2295969074 324 AAATTALERIWkDGHRYAKAGVMLNDFT 351
Cdd:pfam11799 75 RAALRLLRRLY-RGRPVRLLGVSLSNLV 101
|
|
| PRK03858 |
PRK03858 |
DNA polymerase IV; Validated |
5-380 |
1.34e-25 |
|
DNA polymerase IV; Validated
Pssm-ID: 179663 [Multi-domain] Cd Length: 396 Bit Score: 107.38 E-value: 1.34e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 5 ADVNSFYASCERVFRPDLKGKPVVVlsnNDGCIIARSAEAKPW-IKMGTPWFQMKnERYPEKIYAfSSNYELYASMSARV 83
Cdd:PRK03858 9 ADLDSFYASVEQRDDPALRGRPVIV---GGGVVLAASYEAKAYgVRTAMGGRQAR-RLCPQAVVV-PPRMSAYSRASKAV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 84 MSCLEELAPRVEQYSIDEMFLDLTGVEHCMDL-EDFGRQLRQHVYDCTRLTIGVGAGPTKTLAKSAQWASKEwkqfRGVL 162
Cdd:PRK03858 84 FEVFRDTTPLVEGLSIDEAFLDVGGLRRISGTpVQIAARLRRRVREEVGLPITVGVARTKFLAKVASQVAKP----DGLL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 163 ALtrgNPQRTRKLLSLQPVEDIWGVGNRIARKLHVLGIRTALDLA---------LTNPAFIRKNFSVVLERTVRELnges 233
Cdd:PRK03858 160 VV---PPDRELAFLHPLPVRRLWGVGPVTAAKLRAHGITTVGDVAelpesalvsLLGPAAGRHLHALAHNRDPRRV---- 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 234 cmsleEAPPTKQQIVCSRSFGEKVTEYDSLRQAVCQYAERASEKLRKERQYCRHISVFIKTSPFAvkepyygnVATEK-- 311
Cdd:PRK03858 233 -----ETGRRRRSVGAQRALGRGPNSPAEVDAVVVALVDRVARRMRAAGRTGRTVVLRLRFDDFT--------RATRSht 299
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2295969074 312 LLTPTQDTRDIIAAATTALERIWKD-GHRYAK-AGVMLNDFTGSGVSQLQL-FDerpPRPHSAELMKVLDGI 380
Cdd:PRK03858 300 LPRPTASTATLLAAARDLVAAAAPLiAERGLTlVGFAVSNLDDDGAQQLELpFG---LRRPGSALDAALDAV 368
|
|
| PRK02794 |
PRK02794 |
DNA polymerase IV; Provisional |
6-372 |
2.43e-24 |
|
DNA polymerase IV; Provisional
Pssm-ID: 179473 [Multi-domain] Cd Length: 419 Bit Score: 103.86 E-value: 2.43e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 6 DVNSFYASCERVFRPDLKGKPVVVLSNNDG-----CIIAR-----SAeakpwikMgtPWFQMKnERYPEKIyAFSSNYEL 75
Cdd:PRK02794 42 DCDAFYASVEKRDNPELRDKPVIIGGGKRGvvstaCYIARihgvrSA-------M--PMFKAL-KLCPDAV-VIKPDMEK 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 76 YASMSARVMSCLEELAPRVEQYSIDEMFLDLTGVE--HCMD----LEDFGRQLRQHVydctRLTIGVGAGPTKTLAKSAQ 149
Cdd:PRK02794 111 YVRVGREVRAMMQALTPLVEPLSIDEAFLDLSGTErlHGAPpavvLARFARRVEREI----GITVSVGLSYNKFLAKIAS 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 150 WASKEwkqfRGVLALTRGNpqrTRKLLSLQPVEDIWGVGNRIARKLHVLGIRTALDLALTNPAFIRKNFSVVLERTVREL 229
Cdd:PRK02794 187 DLDKP----RGFSVIGRAE---ALAFLAPKPVGIIWGVGPATAARLARDGIRTIGDLQRADEADLMRRFGSMGLRLWRLA 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 230 NGESCMSLEEAPPTKqQIVCSRSFGEKVTEYDSLRQAVCQYAERASEKLRKERQYCRHISVFIKTSPFAVKepyygnVAT 309
Cdd:PRK02794 260 RGIDDRKVSPDREAK-SVSAETTFETDLSDFEDLEPILWRLSEKVSRRLKAAGLAGRTVTLKLKTADFRLR------TRR 332
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2295969074 310 EKLLTPTQDTRDIIAAATTALERIwKDGHRYAKAGVMLNDFT-GSGVSQLQLFDERPPRPHSAE 372
Cdd:PRK02794 333 RTLEDPTQLADRIFRTARELLEKE-TDGTAFRLIGIGVSDLSpADEADPPDLLDPQATRRAAAE 395
|
|
| PRK01216 |
PRK01216 |
DNA polymerase IV; Validated |
1-206 |
8.06e-22 |
|
DNA polymerase IV; Validated
Pssm-ID: 179251 [Multi-domain] Cd Length: 351 Bit Score: 96.01 E-value: 8.06e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 1 MFALADVNSFYASCERVFRPDLKGKPVVVL-----SNNDGCIIARSAEAKPW-IKMGTPWFQMKnERYPEKIYaFSSNYE 74
Cdd:PRK01216 2 IILFVDFDYFFAQVEEVLNPSLKGKPVVVCvysgrFEDSGAVATANYEARKLgIKAGMPIVEAK-KILPNAVY-LPMRKE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 75 LYASMSARVMSCLEELAPRVEQYSIDEMFLDLTG-VEHCMDLEDFGRQLRQHVYDCTRLTIGVGAGPTKTLAKSAqwASK 153
Cdd:PRK01216 80 VYQQVSNRIMKLLREYSEKIEIASIDEAYLDISDkVKNYQDAYNLGLEIKNKILEKEKITVTVGISKNKVFAKIA--ADM 157
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 2295969074 154 EWKQFRGVLaltrgNPQRTRKLLSLQPVEDIWGVGNRIARKLHVLGIRTALDL 206
Cdd:PRK01216 158 AKPNGIKVI-----DDEEVKRFINELDIADIPGIGDITAEKLKKLGVNKLVDT 205
|
|
| DUF4113 |
pfam13438 |
Domain of unknown function (DUF4113); Although the function is not known this domain occurs ... |
373-420 |
2.11e-19 |
|
Domain of unknown function (DUF4113); Although the function is not known this domain occurs almost invariably at the very C-terminus of the IMS family DNA-polymerase repair proteins, IMS, pfam00817.
Pssm-ID: 463876 [Multi-domain] Cd Length: 49 Bit Score: 80.99 E-value: 2.11e-19
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 2295969074 373 LMKVLDGINHS-GLGQVWFAGRGIAPAWQMKRDMLSPAYTTRWKDIPIA 420
Cdd:pfam13438 1 LMAALDAINRRyGRGTVRLAAQGLKRDWKMRREHLSPRYTTRWDELPVV 49
|
|
| PRK02406 |
PRK02406 |
DNA polymerase IV; Validated |
10-361 |
1.21e-16 |
|
DNA polymerase IV; Validated
Pssm-ID: 235035 [Multi-domain] Cd Length: 343 Bit Score: 80.55 E-value: 1.21e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 10 FYASCERVFRPDLKGKPVVVLSNND--GCI-----IAR---------SAEAKpwikmgtpwfqmknERYPEKIYaFSSNY 73
Cdd:PRK02406 4 FYAAVEMRDNPELRGKPVAVGGSPGrrGVIstcnyEARkfgvrsampTAQAL--------------KLCPDLIF-VPGRF 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 74 ELYASMSARVMSCLEELAPRVEQYSIDEMFLDLTGVEHCMdledfG------RQLRQHVYDCTRLTIGVGAGPTKTLAKS 147
Cdd:PRK02406 69 DVYKEVSRQIREIFRRYTDLIEPLSLDEAYLDVTDNKLCI-----GsatliaQEIRQDIFEELGLTASAGVAPNKFLAKI 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 148 aqwASkEWK----QFrgVLAltrgnPQRTRKLLSLQPVEDIWGVGNRIARKLHVLGIRTALDLALTNPAFIRKNFSV--- 220
Cdd:PRK02406 144 ---AS-DWNkpngLF--VIT-----PEEVDAFLATLPVEKIPGVGKVTAEKLHALGIYTCADLQKYDLAELIRHFGKfgr 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 221 VL--------ERTV---RElngescmsleeapptKQQIVCSRSFGEKVTEYDSLRQAVCQYAERASEKLRKErQYCRHIS 289
Cdd:PRK02406 213 RLyerargidERPVkpdRE---------------RKSVGVERTFAEDLYDLEACLAELPRLAEKLERRLERA-KPDKRIK 276
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2295969074 290 ---VFIKTSPFavkepyygNVAT-EKLLTPTQDTRDIIAAATTALERIWKDGHRYAKAGVMLndFTGSGVSQLQLF 361
Cdd:PRK02406 277 tvgVKLKFADF--------QQTTkEHTADPLDKADLIELLAQALLRRLGGRGVRLLGVGVTL--LEPQLERQLLLD 342
|
|
| PolY_Rev1 |
cd01701 |
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. ... |
6-302 |
4.80e-16 |
|
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Rev1 has both structural and enzymatic roles. Structurally, it is believed to interact with other nonclassical polymerases and replication machinery to act as a scaffold. Enzymatically, it catalyzes the specific insertion of dCMP opposite abasic sites. Rev1 interacts with the Rev7 subunit of the B-family TLS polymerase Pol zeta (Rev3/Rev7). Rev1 is known to actively promote the introduction of mutations, potentially making it a significant target for cancer treatment.
Pssm-ID: 176455 [Multi-domain] Cd Length: 404 Bit Score: 79.28 E-value: 4.80e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 6 DVNSFYASCERVFRPDLKGKPVVVlSNNDGC---IIARSAEAKPW-IKMGTpWFQMKNERYPEKIyAFSSNYELYASMSA 81
Cdd:cd01701 53 DFDCFFVSVSIRNRPDLKGKPVAV-CHGKGPnseIASCNYEARSYgIKNGM-WVGQAKKLCPQLV-TLPYDFEAYEEVSL 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 82 RVMSCLEELAPRVEQYSIDEMFLDLTGVEHCM--DLEDFGRQLRQHVYDCTRLTIGVGAGPTKTLAKsaqWASKEWKQfR 159
Cdd:cd01701 130 TFYEILASYTDNIEAVSCDEALIDITSLLEETyeLPEELAEAIRNEIRETTGCSASVGIGPNILLAR---LATRKAKP-D 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 160 GVLALTrgnPQRTRKLLSLQPVEDIWGVGNRIARKLHVLGIRTALDLALtnpafiRKNFSVVLERTVRELNGES----CM 235
Cdd:cd01701 206 GQYHLS---AEKVEEFLSQLKVGDLPGVGSSLAEKLVKLFGDTCGGLEL------RSKTKEKLQKVLGPKTGEKlydyCR 276
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2295969074 236 SLEEAPPTKQQ----IVCSRSFG---EKVTEYDSLRQAVCQYAERaseKLRKERQYCRHISVFIKT-SPFAVKEP 302
Cdd:cd01701 277 GIDDRPVTGEKerksVSAEINYGirfTNVDDVEQFLQRLSEELSK---RLEESNVTGRQITLKLMKrAPGAPIEP 348
|
|
| PolY_Pol_eta |
cd01702 |
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. ... |
3-188 |
1.78e-10 |
|
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Unlike other Y-family members, Pol eta can efficiently and accurately replicate DNA past UV-induced lesions. Its activity is initiated by two simultaneous interactions: the PIP box in pol eta interacting with PCNA, and the UBZ (ubiquitin-binding zinc finger) in pol eta interacting with monoubiquitin attached to PCNA. Pol eta is more efficient in copying damaged DNA than undamaged DNA and seems to recognize when a lesion has been passed, facilitating a lesion-dependent dissociation from the DNA.
Pssm-ID: 176456 [Multi-domain] Cd Length: 359 Bit Score: 61.95 E-value: 1.78e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 3 ALADVNSFYASCERVFRPDLKGKPVVVLSNNDgcIIA--------------RSAEAK-----------PWIKMGT----P 53
Cdd:cd01702 1 AHIDMDAFFAQVEQVRLGLLRNDPVAVVQWNS--IIAvsyaarafgvtrfmTIDEAKkkcpdlilahvATYKKGEdeadY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 54 WFQMKNERYpeKIyafssNYELYASMSARVMSCLEELAPRVEQYSIDEMFLDLTG--VEhcmdledfgrQLRQHVYDCTR 131
Cdd:cd01702 79 HENPSPARH--KV-----SLDPYRRASRKILNILKRFGDVVEKASIDEAYLDLGSriVE----------EIRQQVYDELG 141
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 2295969074 132 LTIGVGAGPTKTLAKSAQWASKEWKQfrgvlalTRGNPQRTRKLLSLQPVEDIWGVG 188
Cdd:cd01702 142 YTCSAGIAHNKMLAKLASGMNKPNAQ-------TILRNDAVASFLSSLPITSIRGLG 191
|
|
| PTZ00205 |
PTZ00205 |
DNA polymerase kappa; Provisional |
6-297 |
2.81e-08 |
|
DNA polymerase kappa; Provisional
Pssm-ID: 140232 [Multi-domain] Cd Length: 571 Bit Score: 55.80 E-value: 2.81e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 6 DVNSFYASCERVFRPDLKGKPVVVLSN---NDGCIIARSAEAKPwikmGTPWFQmkNERYPEKIYAFSSNYELYASMSAR 82
Cdd:PTZ00205 139 DMDMFYAAVEIKKHPEYAAIPLAIGTMtmlQTANYVARGRGIRQ----GMPGFL--ALKICPNLLILPPDFDAYNEESNT 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 83 VMSCLEELAPRVEQYSIDEMFLDLTG----VEHCMDLEDFGRQLRQHVYDCTRLTIGVGAGPTKTLAKSAQWASKEWKQF 158
Cdd:PTZ00205 213 VRRIVAEYDPNYISFGLDELTLEVSAyierFEGTKTAEDVASELRVRVFGETKLTASAGIGPTAALAKIASNINKPNGQH 292
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 159 RGVLAlTRGNPQRTRKLLSLQPVEdiwGVGNRIARKLHVLGIRTALDLALTNPA----FIRKNFSVVLERTV-------- 226
Cdd:PTZ00205 293 DLNLH-TRGDVMTYVRDLGLRSVP---GVGKVTEALLKGLGITTLSDIYNRRVElcyiLHNNLFRFLLGASIgimqwpda 368
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2295969074 227 -RELNGESCmslEEAPPT-KQQIVCSRSFgEKVTEYDSLRQAVCQYAERASEKLRKERQYCRHISVFIKTSPF 297
Cdd:PTZ00205 369 aTAANTENC---EGATGGqRKAISSERSF-TTPRTKEGLQEMVDTVFNGAYEEMRKSELMCRQISLTIRWASY 437
|
|
| PolY_Pol_iota |
cd01703 |
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. ... |
6-233 |
2.06e-06 |
|
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol iota is thought to be one of the least efficient polymerases, particularly when opposite pyrimidines; it can incorporate the correct nucleotide opposite a purine much more efficiently than opposite a pyrimidine, and prefers to insert guanosine instead of adenosine opposite thymidine. Pol iota is believed to use Hoogsteen rather than Watson-Crick base pairing, which may explain the varying efficiency for different template nucleotides.
Pssm-ID: 176457 [Multi-domain] Cd Length: 379 Bit Score: 49.39 E-value: 2.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 6 DVNSFYASCERVFRPDLKGKPV-------VVLSNndgcIIARS---------AEAKpwikmgtpwfqmknERYPEKIYAF 69
Cdd:cd01703 4 DLDCFYAQVEEIRDPSLKSKPLgiqqkyiVVTCN----YEARRlgvkklmsiKDAK--------------EICPDLVLVN 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 70 SSNYELYASMSARVMSCLEELAP--RVEQYSIDEMFLDLTGvehcMDL---EDFGRQLRQHVYDCTRLTIGVGAGPTKTL 144
Cdd:cd01703 66 GEDLTPFRDMSKKVYRLLRSYSWndRVERLGFDENFMDVTE----MRLlvaSHIAYEMRERIENELGLTCCAGIASNKLL 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 145 AKSAQWASKEWKQfrgvLALTRGNPQRTRKLLSLQPVEDIWGVGNRIARKLHVLGIRTALDLALtNPAFIRKNFSVVLER 224
Cdd:cd01703 142 AKLVGSVNKPNQQ----TTLLPPSCADLMDFMDLHDLRKIPGIGYKTAAKLEAHGISSVRDLQE-FSNRNRQTVGAAPSL 216
|
....*....
gi 2295969074 225 TVRELNGES 233
Cdd:cd01703 217 LELLLMVKE 225
|
|
| PolY_like |
cd03468 |
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that ... |
85-331 |
2.45e-05 |
|
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176458 [Multi-domain] Cd Length: 335 Bit Score: 45.84 E-value: 2.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 85 SCLEELA-------PRVEQYSIDEMFLDLTGVEHCMDLED-FGRQLRQHVyDCTRLTIGVGAGPTKTLAKsaqWASKewk 156
Cdd:cd03468 76 RALQELAlwllrftPLVALDGPDGLLLDVTGCLHLFGGEDaLAASLRAAL-ATLGLSARAGIADTPGAAW---LLAR--- 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 157 qFRGVLALTRGNPQRTRKLLSLQPVEDIWGVGNRIARKLHVLGIRTALDLALTNPAFIRKNFSVVLERTVRELNGE--SC 234
Cdd:cd03468 149 -AGGGRGVLRREALAAALVLLAPLPVAALRLPPETVELLARLGLRTLGDLAALPRAELARRFGLALLLRLDQAYGRdpEP 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2295969074 235 MSLEEAPPTKQQIVcSRSFGEKVTE-----YDSLRQAVCQY-------AERASEKLRKERQycRHISVFIKTSPFAVKEP 302
Cdd:cd03468 228 LLFSPPPPAFDFRL-ELQLEEPIARgllfpLRRLLEQLCAFlalrglgARRLSLTLFREDG--RVTRVLVGLARPSRDDL 304
|
250 260 270
....*....|....*....|....*....|.
gi 2295969074 303 YYGNVATEKL--LTPTQDTRDIIAAATTALE 331
Cdd:cd03468 305 PLLRLLRERLerLALPRGIAPVRLLALTAEP 335
|
|
| IMS_HHH |
pfam11798 |
IMS family HHH motif; These proteins are involved in UV protection, eg. |
169-200 |
1.69e-04 |
|
IMS family HHH motif; These proteins are involved in UV protection, eg.
Pssm-ID: 432081 [Multi-domain] Cd Length: 32 Bit Score: 38.53 E-value: 1.69e-04
10 20 30
....*....|....*....|....*....|..
gi 2295969074 169 PQRTRKLLSLQPVEDIWGVGNRIARKLHVLGI 200
Cdd:pfam11798 1 PDDVPEFLWPLPISKIPGIGKKLAEKLKALGI 32
|
|
| |
