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Conserved domains on  [gi|2302722576|ref|WP_259896984|]
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LPXTG cell wall anchor domain-containing protein, partial [Dermabacter hominis]

Protein Classification

Ig-like domain-containing protein( domain architecture ID 1562905)

bacterial immunoglobulin (Ig)-like domain-containing protein may be a cell surface protein and may play an essential role in cell-to-cell recognition, adhesion, biofilm formation, and conjugative transfer

CATH:  2.60.40.10
PubMed:  9417933|10436082|33355339|34986320
SCOP:  3000070

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Big_15 super family cl48770
Bacterial Ig domain (Big_16); This bacterial Ig-like domain is found in the stalk regions of ...
 93-121 2.45e-03

Bacterial Ig domain (Big_16); This bacterial Ig-like domain is found in the stalk regions of bacterial cell surface adhesins.


The actual alignment was detected with superfamily member pfam20622:

Pssm-ID: 466771  Cd Length: 82  Bit Score: 35.58  E-value: 2.45e-03
                          10        20
                  ....*....|....*....|....*....
gi 2302722576  93 DKDAKPGDKVTVVVKDKDGKVIDTVTVTV 121
Cdd:pfam20622  52 DKIKSATDTVTIVAYDKNGKELDTKTVTV 80
Big_6 super family cl39386
Bacterial Ig domain; This domain is found in a wide variety of extracellular bacterial ...
 53-121 6.05e-03

Bacterial Ig domain; This domain is found in a wide variety of extracellular bacterial proteins often in multiple tandem copies.


The actual alignment was detected with superfamily member pfam17936:

Pssm-ID: 465576 [Multi-domain]  Cd Length: 83  Bit Score: 34.52  E-value: 6.05e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2302722576  53 PGDNVVIPNEG---GKVPEGSTVETEGP-----GKAEIDEDGNIRVDIDKDAKPGDKVTVVVKDKDGKVIDTVTVTV 121
Cdd:pfam17936   5 PTNLAVSDDGTtltGTGEAGATVTVKDAdgnvlGTGTVDADGTFSVTLDPAQANGETLSVTATDAAGNVSPAATITA 81
 
Name Accession Description Interval E-value
Big_15 pfam20622
Bacterial Ig domain (Big_16); This bacterial Ig-like domain is found in the stalk regions of ...
 93-121 2.45e-03

Bacterial Ig domain (Big_16); This bacterial Ig-like domain is found in the stalk regions of bacterial cell surface adhesins.


Pssm-ID: 466771  Cd Length: 82  Bit Score: 35.58  E-value: 2.45e-03
                          10        20
                  ....*....|....*....|....*....
gi 2302722576  93 DKDAKPGDKVTVVVKDKDGKVIDTVTVTV 121
Cdd:pfam20622  52 DKIKSATDTVTIVAYDKNGKELDTKTVTV 80
FlgD COG1843
Flagellar hook-capping protein FlgD [Cell motility];
69-119 5.88e-03

Flagellar hook-capping protein FlgD [Cell motility];


Pssm-ID: 441448 [Multi-domain]  Cd Length: 223  Bit Score: 36.52  E-value: 5.88e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2302722576  69 GSTVETEGPGKAEIDEDGNIRVDIDKDAkpgDKVTVVVKDKDGKVIDTVTV 119
Cdd:COG1843    95 GKEVLVEGNTISLDGGSASGGFELPSAA---DSVTVTITDANGNVVRTIDL 142
Big_6 pfam17936
Bacterial Ig domain; This domain is found in a wide variety of extracellular bacterial ...
 53-121 6.05e-03

Bacterial Ig domain; This domain is found in a wide variety of extracellular bacterial proteins often in multiple tandem copies.


Pssm-ID: 465576 [Multi-domain]  Cd Length: 83  Bit Score: 34.52  E-value: 6.05e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2302722576  53 PGDNVVIPNEG---GKVPEGSTVETEGP-----GKAEIDEDGNIRVDIDKDAKPGDKVTVVVKDKDGKVIDTVTVTV 121
Cdd:pfam17936   5 PTNLAVSDDGTtltGTGEAGATVTVKDAdgnvlGTGTVDADGTFSVTLDPAQANGETLSVTATDAAGNVSPAATITA 81
YPDG_rpt NF038186
YPDG domain; The YPDG domain may occur once in a protein, or up to 22 times in tandem repeats. ...
 44-122 6.18e-03

YPDG domain; The YPDG domain may occur once in a protein, or up to 22 times in tandem repeats. It is common in proteins of Gram-positive bacteria with C-terminal LPXTG sites for anchoring on the cell surface.


Pssm-ID: 439498 [Multi-domain]  Cd Length: 98  Bit Score: 34.65  E-value: 6.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302722576  44 PDWKDNSGKPGDNVVIP--------NEGGKVPEGSTVETEGPG----KAEIDED-GNIRVDIDKDAKPGDKVTVVVKDK- 109
Cdd:NF038186    5 PSYEDGTVKPGETVKVPaptfkdkdGKAVDVPEGTKFAPGDAApegwTVTVDEDtGEITVTAPEDAKPGDEVTVPVTVTy 84

                          90
                  ....*....|....
gi 2302722576 110 -DGKViDTVTVTVE 122
Cdd:NF038186   85 pDGST-DEVPATVT 97
 
Name Accession Description Interval E-value
Big_15 pfam20622
Bacterial Ig domain (Big_16); This bacterial Ig-like domain is found in the stalk regions of ...
 93-121 2.45e-03

Bacterial Ig domain (Big_16); This bacterial Ig-like domain is found in the stalk regions of bacterial cell surface adhesins.


Pssm-ID: 466771  Cd Length: 82  Bit Score: 35.58  E-value: 2.45e-03
                          10        20
                  ....*....|....*....|....*....
gi 2302722576  93 DKDAKPGDKVTVVVKDKDGKVIDTVTVTV 121
Cdd:pfam20622  52 DKIKSATDTVTIVAYDKNGKELDTKTVTV 80
FlgD COG1843
Flagellar hook-capping protein FlgD [Cell motility];
69-119 5.88e-03

Flagellar hook-capping protein FlgD [Cell motility];


Pssm-ID: 441448 [Multi-domain]  Cd Length: 223  Bit Score: 36.52  E-value: 5.88e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2302722576  69 GSTVETEGPGKAEIDEDGNIRVDIDKDAkpgDKVTVVVKDKDGKVIDTVTV 119
Cdd:COG1843    95 GKEVLVEGNTISLDGGSASGGFELPSAA---DSVTVTITDANGNVVRTIDL 142
Big_6 pfam17936
Bacterial Ig domain; This domain is found in a wide variety of extracellular bacterial ...
 53-121 6.05e-03

Bacterial Ig domain; This domain is found in a wide variety of extracellular bacterial proteins often in multiple tandem copies.


Pssm-ID: 465576 [Multi-domain]  Cd Length: 83  Bit Score: 34.52  E-value: 6.05e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2302722576  53 PGDNVVIPNEG---GKVPEGSTVETEGP-----GKAEIDEDGNIRVDIDKDAKPGDKVTVVVKDKDGKVIDTVTVTV 121
Cdd:pfam17936   5 PTNLAVSDDGTtltGTGEAGATVTVKDAdgnvlGTGTVDADGTFSVTLDPAQANGETLSVTATDAAGNVSPAATITA 81
YPDG_rpt NF038186
YPDG domain; The YPDG domain may occur once in a protein, or up to 22 times in tandem repeats. ...
 44-122 6.18e-03

YPDG domain; The YPDG domain may occur once in a protein, or up to 22 times in tandem repeats. It is common in proteins of Gram-positive bacteria with C-terminal LPXTG sites for anchoring on the cell surface.


Pssm-ID: 439498 [Multi-domain]  Cd Length: 98  Bit Score: 34.65  E-value: 6.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302722576  44 PDWKDNSGKPGDNVVIP--------NEGGKVPEGSTVETEGPG----KAEIDED-GNIRVDIDKDAKPGDKVTVVVKDK- 109
Cdd:NF038186    5 PSYEDGTVKPGETVKVPaptfkdkdGKAVDVPEGTKFAPGDAApegwTVTVDEDtGEITVTAPEDAKPGDEVTVPVTVTy 84

                          90
                  ....*....|....
gi 2302722576 110 -DGKViDTVTVTVE 122
Cdd:NF038186   85 pDGST-DEVPATVT 97
FLgD_tudor pfam13861
FlgD Tudor-like domain; This domain has a tudor domain-like beta barrel fold. It is found in ...
 69-119 9.55e-03

FlgD Tudor-like domain; This domain has a tudor domain-like beta barrel fold. It is found in the FlgD protein the flagellar hook capping protein. The structure for this domain shows that it contains a nested Ig-like domain within it. However in some firmicute proteins this inserted domain is absent such as Q67K21.


Pssm-ID: 433533  Cd Length: 136  Bit Score: 34.88  E-value: 9.55e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2302722576  69 GSTVETEGpGKAEIDEDG--NIRVDIDKDAkpgDKVTVVVKDKDGKVIDTVTV 119
Cdd:pfam13861  11 GKEVLVPG-DTISLSADGgaTGGVELPSAA---DNVTVTIYDSSGQVVRTIDL 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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