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Conserved domains on  [gi|2308054711|ref|WP_261034861|]
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MULTISPECIES: cysteine hydrolase family protein [Streptococcus]

Protein Classification

cysteine hydrolase family protein( domain architecture ID 10003554)

cysteine hydrolase family protein related to isochorismatase and nicotinamidase; catalyzes the hydrolysis of a chemical bond using an active site cysteinyl residue

CATH:  3.40.50.850
EC:  3.-.-.-
Gene Ontology:  GO:0016787

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PncA COG1335
Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction ...
 4-182 2.43e-49

Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction only]; Nicotinamidase-related amidase is part of the Pathway/BioSystem: Pyrimidine degradation


:

Pssm-ID: 440946 [Multi-domain]  Cd Length: 169  Bit Score: 157.37  E-value: 2.43e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308054711   4 ALISIDYTEDFVADsGKLTAgAPAQEISDAISKVTRLAFERGDYIFFTIDAHEENDCFHPESKLFPPHNLIGTSGRNLYG 83
Cdd:COG1335     1 ALLVIDVQNDFVPP-GALAV-PGADAVVANIARLLAAARAAGVPVIHTRDWHPPDGSEFAEFDLWPPHCVPGTPGAELVP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308054711  84 DLGAFYQEHgsdsrvfWMDKRHYSAFSGTDLDIRLRERRISTVILTGVLTDICVLHTAIDAYNLGYDIEIVKPAVASIWP 163
Cdd:COG1335    79 ELAPLPGDP-------VVDKTRYSAFYGTDLDELLRERGIDTLVVAGLATDVCVLSTARDALDLGYEVTVVEDACASRDP 151

                         170
                  ....*....|....*....
gi 2308054711 164 ENHQFALGHFKNtLGAKLV 182
Cdd:COG1335   152 EAHEAALARLRA-AGATVV 169
 
Name Accession Description Interval E-value
PncA COG1335
Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction ...
 4-182 2.43e-49

Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction only]; Nicotinamidase-related amidase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440946 [Multi-domain]  Cd Length: 169  Bit Score: 157.37  E-value: 2.43e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308054711   4 ALISIDYTEDFVADsGKLTAgAPAQEISDAISKVTRLAFERGDYIFFTIDAHEENDCFHPESKLFPPHNLIGTSGRNLYG 83
Cdd:COG1335     1 ALLVIDVQNDFVPP-GALAV-PGADAVVANIARLLAAARAAGVPVIHTRDWHPPDGSEFAEFDLWPPHCVPGTPGAELVP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308054711  84 DLGAFYQEHgsdsrvfWMDKRHYSAFSGTDLDIRLRERRISTVILTGVLTDICVLHTAIDAYNLGYDIEIVKPAVASIWP 163
Cdd:COG1335    79 ELAPLPGDP-------VVDKTRYSAFYGTDLDELLRERGIDTLVVAGLATDVCVLSTARDALDLGYEVTVVEDACASRDP 151

                         170
                  ....*....|....*....
gi 2308054711 164 ENHQFALGHFKNtLGAKLV 182
Cdd:COG1335   152 EAHEAALARLRA-AGATVV 169
cysteine_hydrolases cd00431
Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine ...
 4-174 2.21e-45

Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It also contains isochorismatase, an enzyme that catalyzes the conversion of isochorismate to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of the vinyl ether bond, and other related enzymes with unknown function.


Pssm-ID: 238245 [Multi-domain]  Cd Length: 161  Bit Score: 147.42  E-value: 2.21e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308054711   4 ALISIDYTEDFVADSGKLTAGAPaqEISDAISKVTRLAFERGDYIFFTIDAHEENDCFHPESkLFPPHNLIGTSGRNLYG 83
Cdd:cd00431     1 ALLVVDMQNDFVPGGGLLLPGAD--ELVPNINRLLAAARAAGIPVIFTRDWHPPDDPEFAEL-LWPPHCVKGTEGAELVP 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308054711  84 DLGAFYQEhgsdsrvFWMDKRHYSAFSGTDLDIRLRERRISTVILTGVLTDICVLHTAIDAYNLGYDIEIVKPAVASIWP 163
Cdd:cd00431    78 ELAPLPDD-------LVIEKTRYSAFYGTDLDELLRERGIDTLVVCGIATDICVLATARDALDLGYRVIVVEDACATRDE 150

                         170
                  ....*....|.
gi 2308054711 164 ENHQFALGHFK 174
Cdd:cd00431   151 EDHEAALERLA 161
Isochorismatase pfam00857
Isochorismatase family; This family are hydrolase enzymes.
 4-183 7.65e-39

Isochorismatase family; This family are hydrolase enzymes.


Pssm-ID: 376404 [Multi-domain]  Cd Length: 173  Bit Score: 130.99  E-value: 7.65e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308054711   4 ALISIDYTEDFVADSGKLTAGApaQEISDAISKVTRLAFERGDYIFFTIDAHEENDCFHPESKLFPPHNLIGTSGRNLYG 83
Cdd:pfam00857   2 ALLVIDMQNDFVDSGGPKVEGI--AAILENINRLLKAARKAGIPVIFTRQVPEPDDADFALKDRPSPAFPPGTTGAELVP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308054711  84 DLGAFYQEHgsdsrVFwmDKRHYSAFSGTDLDIRLRERRISTVILTGVLTDICVLHTAIDAYNLGYDIEIVKPAVASIWP 163
Cdd:pfam00857  80 ELAPLPGDL-----VV--DKTRFSAFAGTDLDEILRELGIDTLVLAGVATDVCVLSTARDALDRGYEVVVVSDACASLSP 152

                         170       180
                  ....*....|....*....|
gi 2308054711 164 ENHQFALGHFKNTlGAKLVD 183
Cdd:pfam00857 153 EAHDAALERLAQR-GAEVTT 171
PTZ00331 PTZ00331
alpha/beta hydrolase; Provisional
 2-183 3.77e-19

alpha/beta hydrolase; Provisional


Pssm-ID: 240363  Cd Length: 212  Bit Score: 81.27  E-value: 3.77e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308054711   2 TKALISIDYTEDFVADsGKLtAGAPAQEISDAISKV-TRLAFergDYIFFTIDAHEENDC-F---HPESK---------L 67
Cdd:PTZ00331   12 NDALIIVDVQNDFCKG-GSL-AVPDAEEVIPVINQVrQSHHF---DLVVATQDWHPPNHIsFasnHGKPKilpdgttqgL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308054711  68 FPPHNLIGTSGRNLYGDL----GAFYQEHGSDSRVfwmDKrhYSAFSG-----TDLDIRLRERRISTVILTGVLTDICVL 138
Cdd:PTZ00331   87 WPPHCVQGTKGAQLHKDLvverIDIIIRKGTNRDV---DS--YSAFDNdkgskTGLAQILKAHGVRRVFICGLAFDFCVL 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 2308054711 139 HTAIDAYNLGYDIEIVKPAVASIWPENHQFALGHFKNtLGAKLVD 183
Cdd:PTZ00331  162 FTALDAVKLGFKVVVLEDATRAVDPDAISKQRAELLE-AGVILLT 205
 
Name Accession Description Interval E-value
PncA COG1335
Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction ...
 4-182 2.43e-49

Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction only]; Nicotinamidase-related amidase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440946 [Multi-domain]  Cd Length: 169  Bit Score: 157.37  E-value: 2.43e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308054711   4 ALISIDYTEDFVADsGKLTAgAPAQEISDAISKVTRLAFERGDYIFFTIDAHEENDCFHPESKLFPPHNLIGTSGRNLYG 83
Cdd:COG1335     1 ALLVIDVQNDFVPP-GALAV-PGADAVVANIARLLAAARAAGVPVIHTRDWHPPDGSEFAEFDLWPPHCVPGTPGAELVP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308054711  84 DLGAFYQEHgsdsrvfWMDKRHYSAFSGTDLDIRLRERRISTVILTGVLTDICVLHTAIDAYNLGYDIEIVKPAVASIWP 163
Cdd:COG1335    79 ELAPLPGDP-------VVDKTRYSAFYGTDLDELLRERGIDTLVVAGLATDVCVLSTARDALDLGYEVTVVEDACASRDP 151

                         170
                  ....*....|....*....
gi 2308054711 164 ENHQFALGHFKNtLGAKLV 182
Cdd:COG1335   152 EAHEAALARLRA-AGATVV 169
cysteine_hydrolases cd00431
Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine ...
 4-174 2.21e-45

Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It also contains isochorismatase, an enzyme that catalyzes the conversion of isochorismate to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of the vinyl ether bond, and other related enzymes with unknown function.


Pssm-ID: 238245 [Multi-domain]  Cd Length: 161  Bit Score: 147.42  E-value: 2.21e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308054711   4 ALISIDYTEDFVADSGKLTAGAPaqEISDAISKVTRLAFERGDYIFFTIDAHEENDCFHPESkLFPPHNLIGTSGRNLYG 83
Cdd:cd00431     1 ALLVVDMQNDFVPGGGLLLPGAD--ELVPNINRLLAAARAAGIPVIFTRDWHPPDDPEFAEL-LWPPHCVKGTEGAELVP 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308054711  84 DLGAFYQEhgsdsrvFWMDKRHYSAFSGTDLDIRLRERRISTVILTGVLTDICVLHTAIDAYNLGYDIEIVKPAVASIWP 163
Cdd:cd00431    78 ELAPLPDD-------LVIEKTRYSAFYGTDLDELLRERGIDTLVVCGIATDICVLATARDALDLGYRVIVVEDACATRDE 150

                         170
                  ....*....|.
gi 2308054711 164 ENHQFALGHFK 174
Cdd:cd00431   151 EDHEAALERLA 161
Isochorismatase pfam00857
Isochorismatase family; This family are hydrolase enzymes.
 4-183 7.65e-39

Isochorismatase family; This family are hydrolase enzymes.


Pssm-ID: 376404 [Multi-domain]  Cd Length: 173  Bit Score: 130.99  E-value: 7.65e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308054711   4 ALISIDYTEDFVADSGKLTAGApaQEISDAISKVTRLAFERGDYIFFTIDAHEENDCFHPESKLFPPHNLIGTSGRNLYG 83
Cdd:pfam00857   2 ALLVIDMQNDFVDSGGPKVEGI--AAILENINRLLKAARKAGIPVIFTRQVPEPDDADFALKDRPSPAFPPGTTGAELVP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308054711  84 DLGAFYQEHgsdsrVFwmDKRHYSAFSGTDLDIRLRERRISTVILTGVLTDICVLHTAIDAYNLGYDIEIVKPAVASIWP 163
Cdd:pfam00857  80 ELAPLPGDL-----VV--DKTRFSAFAGTDLDEILRELGIDTLVLAGVATDVCVLSTARDALDRGYEVVVVSDACASLSP 152

                         170       180
                  ....*....|....*....|
gi 2308054711 164 ENHQFALGHFKNTlGAKLVD 183
Cdd:pfam00857 153 EAHDAALERLAQR-GAEVTT 171
PTZ00331 PTZ00331
alpha/beta hydrolase; Provisional
 2-183 3.77e-19

alpha/beta hydrolase; Provisional


Pssm-ID: 240363  Cd Length: 212  Bit Score: 81.27  E-value: 3.77e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308054711   2 TKALISIDYTEDFVADsGKLtAGAPAQEISDAISKV-TRLAFergDYIFFTIDAHEENDC-F---HPESK---------L 67
Cdd:PTZ00331   12 NDALIIVDVQNDFCKG-GSL-AVPDAEEVIPVINQVrQSHHF---DLVVATQDWHPPNHIsFasnHGKPKilpdgttqgL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308054711  68 FPPHNLIGTSGRNLYGDL----GAFYQEHGSDSRVfwmDKrhYSAFSG-----TDLDIRLRERRISTVILTGVLTDICVL 138
Cdd:PTZ00331   87 WPPHCVQGTKGAQLHKDLvverIDIIIRKGTNRDV---DS--YSAFDNdkgskTGLAQILKAHGVRRVFICGLAFDFCVL 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 2308054711 139 HTAIDAYNLGYDIEIVKPAVASIWPENHQFALGHFKNtLGAKLVD 183
Cdd:PTZ00331  162 FTALDAVKLGFKVVVLEDATRAVDPDAISKQRAELLE-AGVILLT 205
EntB1 COG1535
Isochorismate hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
4-170 1.22e-16

Isochorismate hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441144 [Multi-domain]  Cd Length: 204  Bit Score: 74.12  E-value: 1.22e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308054711   4 ALISIDYTEDFVADSGKltAGAPAQEISDAISKVTRLAFERGDYIFFTIDAHEEndcfHPE-----SKLFPPHNLIGTSG 78
Cdd:COG1535    21 ALLIHDMQNYFLRPYDP--DEPPIRELVANIARLRDACRAAGIPVVYTAQPGDQ----TPEdrgllNDFWGPGLTAGPEG 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308054711  79 RNLYGDLgafyqEHGSDSRVFwmDKRHYSAFSGTDLDIRLRERRISTVILTGVLTDICVLHTAIDAYNLGYDIEIVKPAV 158
Cdd:COG1535    95 QEIVDEL-----APAPGDTVL--TKWRYSAFQRTDLEERLRELGRDQLIITGVYAHIGCLATAVDAFMRDIQPFVVADAV 167

                         170
                  ....*....|..
gi 2308054711 159 ASIWPENHQFAL 170
Cdd:COG1535   168 ADFSREEHRMAL 179
nicotinamidase cd01011
Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, ...
 2-182 6.76e-15

Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is also called pyrazinamidase, because in converts the tuberculosis drug pyrazinamide (PZA) into its active form pyrazinoic acid (POA).


Pssm-ID: 238493  Cd Length: 196  Bit Score: 69.60  E-value: 6.76e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308054711   2 TKALISIDYTEDFVaDSGKLtAGAPAQEISDAISKVTRLAfeRGDYIFFTIDAHEENDC----FHPESKLF--------- 68
Cdd:cd01011     1 TDALLVVDVQNDFC-PGGAL-AVPGGDAIVPLINALLSLF--QYDLVVATQDWHPANHAsfasNHPGQMPFitlppgpqv 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308054711  69 --PPHNLIGTSGRNLYGDLG----AFYQEHGSDSrvfwmDKRHYSAF------SGTDLDIRLRERRISTVILTGVLTDIC 136
Cdd:cd01011    77 lwPDHCVQGTPGAELHPGLPvpdiDLIVRKGTNP-----DIDSYSAFfdndrrSSTGLAEYLRERGIDRVDVVGLATDYC 151

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 2308054711 137 VLHTAIDAYNLGYDIEIVKPAVASIWPENHQFALGHFKnTLGAKLV 182
Cdd:cd01011   152 VKATALDALKAGFEVRVLEDACRAVDPETIERAIEEMK-EAGVVLV 196
PRK11440 PRK11440
putative hydrolase; Provisional
 103-172 8.80e-14

putative hydrolase; Provisional


Pssm-ID: 183137  Cd Length: 188  Bit Score: 66.29  E-value: 8.80e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308054711 103 KRHYSAFSGTDLDIRLRERRISTVILTGVLTDICVLHTAIDAYNLGYDIEIVKPAVASIWPENHQFALGH 172
Cdd:PRK11440  101 KRQWGAFYGTDLELQLRRRGIDTIVLCGISTNIGVESTARNAWELGFNLVIAEDACSAASAEQHQNSMNH 170
nicotinamidase_related cd01014
Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share ...
 4-160 2.86e-13

Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia.


Pssm-ID: 238496 [Multi-domain]  Cd Length: 155  Bit Score: 64.15  E-value: 2.86e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308054711   4 ALISIDYTEDFVadsgklTAGAPAQEISDAISKVTRL---AFERGDYIFFTidAHEEndcfhPESKLFPPhnliGTSGRN 80
Cdd:cd01014     1 ALLVIDVQNGYF------DGGLPPLNNEAALENIAALiaaARAAGIPVIHV--RHID-----DEGGSFAP----GSEGWE 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308054711  81 LYGDLGAfyqehGSDSRVFwmDKRHYSAFSGTDLDIRLRERRISTVILTGVLTDICVLHTAIDAYNLGYDIEIVKPAVAS 160
Cdd:cd01014    64 IHPELAP-----LEGETVI--EKTVPNAFYGTDLEEWLREAGIDHLVICGAMTEMCVDTTVRSAFDLGYDVTVVADACAT 136
CSHase cd01015
N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, ...
 4-179 1.57e-12

N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This CSHase-containing pathway degrades creatinine via N-methylhydantoin N-carbamoylsarcosine and sarcosine to glycine. Enzymes of this pathway are used in the diagnosis for renal disfunction, for determining creatinine levels in urine and serum.


Pssm-ID: 238497 [Multi-domain]  Cd Length: 179  Bit Score: 62.80  E-value: 1.57e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308054711   4 ALISIDYTEDFvADSGKLTAGapaqEISDAISKVTRL---AFERGDYIFFTIDAHEENDCFHPESKLFPPHNLIGTSGrn 80
Cdd:cd01015     1 ALLVIDLVEGY-TQPGSYLAP----GIAAALENVQRLlaaARAAGVPVIHTTVVYDPDGADGGLWARKVPAMSDLVEG-- 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308054711  81 lyGDLGAFYQEHGSDSRVFWMDKRHYSAFSGTDLDIRLRERRISTVILTGVLTDICVLHTAIDAYNLGYDIEIVKPAVAS 160
Cdd:cd01015    74 --SPLAAICDELAPQEDEMVLVKKYASAFFGTSLAATLTARGVDTLIVAGCSTSGCIRATAVDAMQHGFRPIVVRECVGD 151

                         170
                  ....*....|....*....
gi 2308054711 161 IWPENHQFALGHFKNTLGA 179
Cdd:cd01015   152 RAPAPHEANLFDIDNKYGD 170
YcaC_related cd01012
YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown ...
 101-170 1.15e-11

YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them. Multimerisation interface seems not to be conserved in all members.


Pssm-ID: 238494 [Multi-domain]  Cd Length: 157  Bit Score: 59.92  E-value: 1.15e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308054711 101 MDKRHYSAFSGTDLDIRLRERRISTVILTGVLTDICVLHTAIDAYNLGYDIEIVKPAVASIWPENHQFAL 170
Cdd:cd01012    66 IEKTSFSCWEDEAFRKALKATGRKQVVLAGLETHVCVLQTALDLLEEGYEVFVVADACGSRSKEDHELAL 135
isochorismatase cd01013
Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the ...
 101-170 7.21e-09

Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological systems. Isochorismatase is part of the phenazine biosynthesis pathway. Phenazines are antimicrobial compounds that provide the competitive advantage for certain bacteria.


Pssm-ID: 238495  Cd Length: 203  Bit Score: 53.11  E-value: 7.21e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2308054711 101 MDKRHYSAFSGTDLDIRLRERRISTVILTGVLTDICVLHTAIDAYNLgyDIE--IVKPAVASIWPENHQFAL 170
Cdd:cd01013   120 LTKWRYSAFKRSPLLERLKESGRDQLIITGVYAHIGCLSTAVDAFMR--DIQpfVVADAIADFSLEEHRMAL 189
PLN02743 PLN02743
nicotinamidase
 18-149 1.20e-08

nicotinamidase


Pssm-ID: 215396  Cd Length: 239  Bit Score: 52.82  E-value: 1.20e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308054711  18 SGKLTAGAPAQEISDAISKVTRLA--F-ERGDYIFFTIDAHEENDCFHPesklFPPHNLIGTSGRNLYGDLgafyQEHGS 94
Cdd:PLN02743   44 AGNLAPREPDKQISKMVDESARLAreFcERKWPVLAFLDSHHPDKPEHP----YPPHCIVGTGEENLVPAL----QWLEN 115

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2308054711  95 DSRVFWMDKRHYSAFSGTdldIR----------LRERRISTVILTGVLTDICVLH---TAIDAYNLGY 149
Cdd:PLN02743  116 DPNVTLRRKDCIDGFVGA---IEkdgsnvfvdwVNNNKIKVILVVGICTDICVLDfvaSALSARNHGI 180
PLN02621 PLN02621
nicotinamidase
 102-170 1.31e-08

nicotinamidase


Pssm-ID: 178229  Cd Length: 197  Bit Score: 52.48  E-value: 1.31e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2308054711 102 DKRHYSAFSGTDLDIRLRERRISTVILTGVLTDICVLHTAIDAYNLGYDIEIVKPAVASIWPENHQFAL 170
Cdd:PLN02621  106 EKSTYSAFYNTRLEERLRKIGVKEVIVTGVMTNLCCETTAREAFVRGFRVFFSTDATATANEELHEATL 174
PRK11609 PRK11609
bifunctional nicotinamidase/pyrazinamidase;
106-154 2.98e-07

bifunctional nicotinamidase/pyrazinamidase;


Pssm-ID: 183228  Cd Length: 212  Bit Score: 48.83  E-value: 2.98e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2308054711 106 YSAF------SGTDLDIRLRERRISTVILTGVLTDICVLHTAIDAYNLGYDIEIV 154
Cdd:PRK11609  119 YSAFfdnghrQKTALDDWLREHGITELIVMGLATDYCVKFTVLDALALGYQVNVI 173
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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