|
Name |
Accession |
Description |
Interval |
E-value |
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
9-694 |
0e+00 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 587.50 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 9 VRFRYGVLLIWAILLAGSVYFGLQLPGELRGNGFAIQDGRFQQVEDQLNERF-DRAGASMIVLFEGGN-------LEAVM 80
Cdd:COG2409 2 ARHRWLVLLAWLVLLVALGVLAPQLGGSLSSNGFFLPGSESQRAADLLAEAFpESDGASAVVVVEAPDgtltdpaFRAAV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 81 DEQQDRFGEISSIDGVITPAENPDARS----GDVSYFVLEF--EDYDAAESSIDAVRDAL--IVDTDTEVRLTGEPVFAD 152
Cdd:COG2409 82 AALVARLRADPGVAGVQDPWDDPAAGLvsedGKAALVTVTLdgDAGDEAAEAVDALRDAVaaAPAPGLTVYVTGPAALAA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 153 DLNEASKNDLIRAELIGIPVALLVLLLVFGTPLAALMPLLVGLITFIVAAGSLFFFAQNMELSIFVLNAVAMIAIALGID 232
Cdd:COG2409 162 DLNEAFEEDLGRAELITLPVALVVLLLVFRSLVAALLPLLTAGLAVGVALGLLALLAAFTDVSSFAPNLLTMLGLGVGID 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 233 FSLLLVNRYREELTRGQSREEAIVRTVATAGRSILFSGLCVFVGLAGLLFIQVDVFQAVALGALIAVAGAVLSALTLLPS 312
Cdd:COG2409 242 YALFLVSRYREELRAGEDREEAVARAVATAGRAVLFSGLTVAIALLGLLLAGLPFLRSMGPAAAIGVAVAVLAALTLLPA 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 313 SLYLVGDALNKGRIIKTDETKSEK--RWQKLARFVMRRPVTMTLIALLILLPSLWFVRDLELNIPDADALPTSYESRAAL 390
Cdd:COG2409 322 LLALLGRRVFWPRRPRRRRAAAPEsgFWRRLARAVVRRPVPVLVAAVAVLLALALPALGLRLGLPDADSLPADSPSRQGY 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 391 ERWDDVFGDNSTD-AVLLFEANDLTDPMILEELTSLIDELNEVDIVDNVStflttsgltpetftqlaeaapeqlaPLERL 469
Cdd:COG2409 402 DALAEHFPPGSNGpLTVVVESDDDLDPADLAALDALAAALAAVPGVASVQ-------------------------PPTRP 456
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 470 VTLDGNTdlALVNVSFDVPPSDKEAQAFVRDWRDK--------EFEVGGPAAFNEEIYDEIYDSIPYAVITVILATFFIL 541
Cdd:COG2409 457 EGTDGDA--ARLQVVPDGDPDSPEAIDLVDRLRDAaapalegaEVLVGGTTAVNIDISDALADDLPLVIPVVLGLIFLLL 534
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 542 MWAFRSILIPIKAILMNVLGLGATFGLLVIVFESGYV---YDAETISILTPVFIFSLVFGLSMDYEVFLVSRIEEYYRET 618
Cdd:COG2409 535 LLLFRSVVAPLKAVLTNLLSLGAALGVLVLVFQHGWLllgFTPGPLDSFVPLLLFVILFGLGMDYEVFLVSRIREEYDRG 614
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2321701453 619 GDNDYATEMGLAKTSKIITSAAIIMIVVTGAFAFTGVSPIKQLGVGIALAIFIDATIIRILLVPSLMKLFGDWNWW 694
Cdd:COG2409 615 GGTREAVIRGLARTGRVITSAALIMAAVFAAFATSPLVFLKQIGFGLAVGVLLDAFVVRMLLVPALMALLGRWNWW 690
|
|
| MMPL |
pfam03176 |
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ... |
42-351 |
6.47e-43 |
|
MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.
Pssm-ID: 308676 [Multi-domain] Cd Length: 332 Bit Score: 158.22 E-value: 6.47e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 42 FAIQDGRFQQVEDQLNERF---DRAGASMIVLFEGGNL------EAVMDEQQDRFGEISSIDGVITPA-ENPDARSGDVS 111
Cdd:pfam03176 2 LSPADAPSVRAMDRLGAAFpqaDSDPIIVVVLGEGDQAlgdaaaEAGYDTLVDALRADTGHVGSVQDFwGDPDTAALFVS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 112 ------YFVLEFE---DYDAAESSIDAVRDAL---IVDTDTEVRLTGEPVFADDLNEASKNDLIRAELIGIPVALLVLLL 179
Cdd:pfam03176 82 pdgkaaYVVVTLEgdpGTTEADESVAAVRDAVeqaPPPEGLKAYLTGPAATVADLRDAGDRDLGLIEAVTLVVIFIILLI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 180 VFGTPLAALMPLLVGLITFIVAAGSLFFFAQN--MELSIFVLNAVAMIAIALGIDFSLLLVNRYREELTRGQSREEAIVR 257
Cdd:pfam03176 162 VYRSVVAALLPLLTVGLSLGAAQGLVAILAHIlgIGLSTFALNLLVVLLIAVGTDYALFLVSRYREELRAGEDREEAVIR 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 258 TVATAGRSILFSGLCVFVGLAGLLFIQVDVFQAVALGALIAVAGAVLSALTLLPSSLYLVGDAlnkgRIIKTDETKSEKR 337
Cdd:pfam03176 242 AVRGTGKVVTAAGLTVAIAMLALSFARLPVFAQVGPTIAIGVLVDVLAALTLLPALLALLGRW----GLWPPKRDRTARW 317
|
330
....*....|....
gi 2321701453 338 WQKLARFVMRRPVT 351
Cdd:pfam03176 318 WRRIGRLVVRRPAP 331
|
|
| actII |
TIGR00833 |
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ... |
10-694 |
1.32e-37 |
|
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 129913 [Multi-domain] Cd Length: 910 Bit Score: 150.89 E-value: 1.32e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 10 RFRYGVLLIW-AILLAGSVYFG-LQLPGELRGNGFAIQDG---RFQQVEDQLNERFDRAGASMIVLFEGGNLEA------ 78
Cdd:TIGR00833 1 RSAYGIIGVWiATAISLQLLAPlLEDVSYFRLQAELPGGAassIAVKEMSAAFQEAIRDPKIILVLESNERLGDkdyaty 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 79 ---VMDEQQDRFGEISSIDGVITPAENPDARSGDVS--YFVLEF---EDYDAAESSIDAVRdALIVDTDT----EVRLTG 146
Cdd:TIGR00833 81 dalIAKLRADIMHVISVVDFWGPPEAAEGLRSDDGKatIIIVNLageKGQKEAQEAINAVR-RIVEQTNApdglTVHVTG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 147 EPVFADDLNEASKNDLIRAELIGIPVALLVLLLVFGTPLAALMPLLVGLITFIVAAGSLFFFAQN--MELSIFVLNAVAM 224
Cdd:TIGR00833 160 PLATIADILESGDKDMNRITATTGIIVLIILLLVYRSPITMLVPLVSVGFSVVVAQGIVSLLGIPglIGVNAQTTVLLTA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 225 IAIALGIDFSLLLVNRYREELTRGQSREEAIVRTVATAGRSILFSGLCVFVGLAGLLFIQVDVFQAVALGALIAVAGAVL 304
Cdd:TIGR00833 240 LVIGAGTDYAVFLTGRYHEERRKGESLEEAAAEALRGTGKAILGSALTVAVAFLALSLARLPSFKTLGVSCAVGVLVALL 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 305 SALTLLPSSLYLVGDAlnkGRIIKTDETKSEKRWQKLARFVMRRPVTMTLIALLILLPSLWFVRDLELNIPDADALPTSY 384
Cdd:TIGR00833 320 NAVTLTPALLTLEGRE---GLMKPGRKSKIRFIWRRLGTAVVRRPWPILVTTLIISGVSLLALPLIRTGYDDEKMIPTDL 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 385 ESRAALERWDDVFGDNSTDAVLLF--EANDLTDPMILEELTSLIDELNEVDIVDNV------------------------ 438
Cdd:TIGR00833 397 ESVQGYEAADRHFPGNSMDPMVVMikSDHDVRNPALLADIDRFEREIKAVPGINMVqetqrpdgvvikktyltfqagnlg 476
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 439 ---STFLTTSGLTPETFTQLAEAAPEQLAPLERLVTL------------------------------------------- 472
Cdd:TIGR00833 477 dqlDEFSDQLTSRQAYLLQDAEKIAEAIAGLRLVQAGmrldgenlgqvslavrlmqqaisklqgsagdvfdifdplrrfv 556
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 --------------------------------------------------------------------------------
Cdd:TIGR00833 557 aaipecranpvcsvareivqaadtvvssaakladaagqlargiadvasalsqvsglpnaldgigtqlaqmresaagvqdl 636
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 473 -----------------DGNTDLALVNVSFDVPPSDKEAQAFVR------------------------------------ 499
Cdd:TIGR00833 637 lnelsdysmtmgklkgnAMGVDFYAPPRIFTDPNFKAVLDYFLSpdghaarllvygdgspagdqgaqefnairtvaeeai 716
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 500 ---DWRDKEFEVGGPAAFNEEIYDEIYDSIPYAVITVILATFFILMWAFRSILIPIKAILMNVLGLGATFGLLVIVFEsg 576
Cdd:TIGR00833 717 qraDLEPAKVELAGVSAVNRDLRDLVNSDLGLISIITLAIVFMILALLLRAPVAPIVLIGSVALSYLWALGLSVLAFQ-- 794
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 577 YVYDAETISiLTPVFIFSLVFGLSMDYEVFLVSRIEEYYREtgDNDYATEMGLAKTSKIITSAAIIMIVVTGAFAFTGVS 656
Cdd:TIGR00833 795 HILGAELHW-SVLAGVFVLLVALGVDYNMLLVSRIKEESPA--GNRTGIIRALGSTGGVITAAGLVFAGTMAALASAQLT 871
|
890 900 910
....*....|....*....|....*....|....*...
gi 2321701453 657 PIKQLGVGIALAIFIDATIIRILLVPSLMKLFGDWNWW 694
Cdd:TIGR00833 872 AIAQFGFTVGVGILLDTFIVRSVTVPALTLLLGRWIWW 909
|
|
| PRK09579 |
PRK09579 |
multidrug efflux RND transporter permease subunit; |
185-378 |
7.47e-04 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 169983 [Multi-domain] Cd Length: 1017 Bit Score: 42.90 E-value: 7.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 185 LAALMPLLVGLITFIVAAGSLFFFAQNMELSIFVLNAVAMI-AIALGIDFSLLLVNRYREELTRGQS---------REEA 254
Cdd:PRK09579 352 LGALRSVLIPVVTIPLSMIGVLFFMQMMGYSINLLTLLAMVlAIGLVVDDAIVVVENIHRHIEEGKSpfdaalegaREIA 431
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 255 IVRTVATAGRSILFSGLCVFVGLAGLLFIQVdvfqAVALGALIAVAGAVlsALTLLP--SSLYLVGDALNKGRIIKTDE- 331
Cdd:PRK09579 432 MPVVSMTITLAAVYAPIGFLTGLTGALFKEF----ALTLAGAVIISGIV--ALTLSPmmCALLLRHEENPSGLAHRLDRl 505
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 2321701453 332 -TKSEKRWQKLARFVMR-RPVTMTL-IALLILLPSLWFVRDLELnIPDAD 378
Cdd:PRK09579 506 fERLKQRYQRALHGTLNtRPVVLVFaVIVLALIPVLLKFTQSEL-APEED 554
|
|
| RND_permease_2 |
NF033617 |
multidrug efflux RND transporter permease subunit; |
186-366 |
3.38e-03 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 411236 [Multi-domain] Cd Length: 1009 Bit Score: 40.77 E-value: 3.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 186 AALMPLLVGLITFIvaagSLFFFAQNMELSIFVLNAVAM-IAIALGIDFSLLLVNRYREELTRGQSREEAIV---RTVAT 261
Cdd:NF033617 356 ATLIPAVTVPLSLI----GTFAVMYLFGFSINLLTLMALvLAIGLVVDDAIVVVENIHRHIEEGESPLEAALkgaREIGF 431
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 262 AGRSILFSGLCVFV------GLAGLLFIQVdvfqAVALGALIAVAGAVlsALTLLP---SSLYLVGDALNK-GRIIKTDE 331
Cdd:NF033617 432 TVIAMTLTLVAVYLpilfmgGLTGRLFREF----AVTLAGAVIISGIV--ALTLTPmmcSRLLKANEKPGRfARAVDRFF 505
|
170 180 190
....*....|....*....|....*....|....*
gi 2321701453 332 TKSEKRWQKLARFVMRRPVTMTLIALLILLPSLWF 366
Cdd:NF033617 506 DGLTARYGRGLKWVLKHRPLTLVVALATLALLPLL 540
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
9-694 |
0e+00 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 587.50 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 9 VRFRYGVLLIWAILLAGSVYFGLQLPGELRGNGFAIQDGRFQQVEDQLNERF-DRAGASMIVLFEGGN-------LEAVM 80
Cdd:COG2409 2 ARHRWLVLLAWLVLLVALGVLAPQLGGSLSSNGFFLPGSESQRAADLLAEAFpESDGASAVVVVEAPDgtltdpaFRAAV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 81 DEQQDRFGEISSIDGVITPAENPDARS----GDVSYFVLEF--EDYDAAESSIDAVRDAL--IVDTDTEVRLTGEPVFAD 152
Cdd:COG2409 82 AALVARLRADPGVAGVQDPWDDPAAGLvsedGKAALVTVTLdgDAGDEAAEAVDALRDAVaaAPAPGLTVYVTGPAALAA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 153 DLNEASKNDLIRAELIGIPVALLVLLLVFGTPLAALMPLLVGLITFIVAAGSLFFFAQNMELSIFVLNAVAMIAIALGID 232
Cdd:COG2409 162 DLNEAFEEDLGRAELITLPVALVVLLLVFRSLVAALLPLLTAGLAVGVALGLLALLAAFTDVSSFAPNLLTMLGLGVGID 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 233 FSLLLVNRYREELTRGQSREEAIVRTVATAGRSILFSGLCVFVGLAGLLFIQVDVFQAVALGALIAVAGAVLSALTLLPS 312
Cdd:COG2409 242 YALFLVSRYREELRAGEDREEAVARAVATAGRAVLFSGLTVAIALLGLLLAGLPFLRSMGPAAAIGVAVAVLAALTLLPA 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 313 SLYLVGDALNKGRIIKTDETKSEK--RWQKLARFVMRRPVTMTLIALLILLPSLWFVRDLELNIPDADALPTSYESRAAL 390
Cdd:COG2409 322 LLALLGRRVFWPRRPRRRRAAAPEsgFWRRLARAVVRRPVPVLVAAVAVLLALALPALGLRLGLPDADSLPADSPSRQGY 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 391 ERWDDVFGDNSTD-AVLLFEANDLTDPMILEELTSLIDELNEVDIVDNVStflttsgltpetftqlaeaapeqlaPLERL 469
Cdd:COG2409 402 DALAEHFPPGSNGpLTVVVESDDDLDPADLAALDALAAALAAVPGVASVQ-------------------------PPTRP 456
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 470 VTLDGNTdlALVNVSFDVPPSDKEAQAFVRDWRDK--------EFEVGGPAAFNEEIYDEIYDSIPYAVITVILATFFIL 541
Cdd:COG2409 457 EGTDGDA--ARLQVVPDGDPDSPEAIDLVDRLRDAaapalegaEVLVGGTTAVNIDISDALADDLPLVIPVVLGLIFLLL 534
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 542 MWAFRSILIPIKAILMNVLGLGATFGLLVIVFESGYV---YDAETISILTPVFIFSLVFGLSMDYEVFLVSRIEEYYRET 618
Cdd:COG2409 535 LLLFRSVVAPLKAVLTNLLSLGAALGVLVLVFQHGWLllgFTPGPLDSFVPLLLFVILFGLGMDYEVFLVSRIREEYDRG 614
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2321701453 619 GDNDYATEMGLAKTSKIITSAAIIMIVVTGAFAFTGVSPIKQLGVGIALAIFIDATIIRILLVPSLMKLFGDWNWW 694
Cdd:COG2409 615 GGTREAVIRGLARTGRVITSAALIMAAVFAAFATSPLVFLKQIGFGLAVGVLLDAFVVRMLLVPALMALLGRWNWW 690
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
1-691 |
3.43e-69 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 241.30 E-value: 3.43e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 1 MEWLGRQLVRFRYGVLLIWAILLAGSVYFGLQLPGELRGNGFAIQDGRFQQVEDQLNERFDRAGASMIV------LFEGG 74
Cdd:COG1033 4 MERLARFILRHRKLVLLLFLLLTLLLAYGAPKLEVDTDFESLLPEDDPSVQAYDEFEEEFGGDDTVVVAvegkddIFTPE 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 75 NLEAvMDEQQDRFGEISSIDGVITPAENPDARSGDVSYFVLEF--EDYDAAESSIDAVRDAL------------------ 134
Cdd:COG1033 84 TLEA-LRELTEELEEIPGVDSVTSLTNVRATEGTEDGLTVEPLipDELPASPEELAELREKVlssplyvgrlvspdgkat 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 135 ------------------------------IVDTDTEVRLTGEPVFADDLNEASKNDLIRAELIGIPVALLVLLLVFGTP 184
Cdd:COG1033 163 livvtldpdplssdldrkevvaeiraiiakYEDPGVEVYLTGFPVLRGDIAEAIQSDLAIFFPLALLLILLLLFLFFRSL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 185 LAALMPLLVGLITFIVAAGSLFFFaqNMELSIFVLNAVAMIaIALGIDFSLLLVNRYREELTRGQSREEAIVRTVATAGR 264
Cdd:COG1033 243 RGVLLPLLVVLLAVIWTLGLMGLL--GIPLSPLTILVPPLL-LAIGIDYGIHLLNRYREERRKGLDKREALREALRKLGP 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 265 SILFSGLCVFVGLAGLLFIQVDVFQAVALGALIAVAGAVLSALTLLPSSLYLVgDALNKGRIIKTDETKSEKRWQKLARF 344
Cdd:COG1033 320 PVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTLLPALLSLL-PRPKPKTRRLKKPPELGRLLAKLARF 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 345 VMRRPVTMTLIALLILLPSLWFVRDLELNIPDADALPTSYESRAALERWDDVFGdNSTDAVLLFEA---NDLTDPMILEE 421
Cdd:COG1033 399 VLRRPKVILVVALVLAVVSLYGISRLKVEYDFEDYLPEDSPIRQDLDFIEENFG-GSDPLEVVVDTgepDGLKDPEVLKE 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 422 LTSLIDELNEVDIVDNVSTFLTTSGLT--------------PETFTQLAEAAPEQLAP----LERLVTLDGNTdlALVNV 483
Cdd:COG1033 478 IDRLQDYLESLPEVGKVLSLADLVKELnqalnegdpkyyalPESRELLAQLLLLLSSPpgddLSRFVDEDYSA--ARVTV 555
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 484 SFDVPPSD--KEAQAFVRDWRDKEF-------EVGGPAAFNEEIYDEIYDSIPYAVITVILATFFILMWAFRSILIPIKA 554
Cdd:COG1033 556 RLKDLDSEeiKALVEEVRAFLAENFppdgvevTLTGSAVLFAAINESVIESQIRSLLLALLLIFLLLLLAFRSLRLGLIS 635
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 555 ILMNVLGLGATFGLLVIvfeSGYVYDAETIsiltpvFIFSLVFGLSMDYEVFLVSRIEEYYRETGDNDYATEMGLAKTSK 634
Cdd:COG1033 636 LIPNLLPILLTFGLMGL---LGIPLNIATA------VVASIALGIGVDYTIHFLSRYREERRKGGDLEEAIRRALRTTGK 706
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|....*..
gi 2321701453 635 IITSAAIIMIVVTGAFAFTGVSPIKQLGVGIALAIFIdATIIRILLVPSLMKLFGDW 691
Cdd:COG1033 707 AILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLV-ALLAALLLLPALLLLLDPR 762
|
|
| MMPL |
pfam03176 |
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ... |
42-351 |
6.47e-43 |
|
MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.
Pssm-ID: 308676 [Multi-domain] Cd Length: 332 Bit Score: 158.22 E-value: 6.47e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 42 FAIQDGRFQQVEDQLNERF---DRAGASMIVLFEGGNL------EAVMDEQQDRFGEISSIDGVITPA-ENPDARSGDVS 111
Cdd:pfam03176 2 LSPADAPSVRAMDRLGAAFpqaDSDPIIVVVLGEGDQAlgdaaaEAGYDTLVDALRADTGHVGSVQDFwGDPDTAALFVS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 112 ------YFVLEFE---DYDAAESSIDAVRDAL---IVDTDTEVRLTGEPVFADDLNEASKNDLIRAELIGIPVALLVLLL 179
Cdd:pfam03176 82 pdgkaaYVVVTLEgdpGTTEADESVAAVRDAVeqaPPPEGLKAYLTGPAATVADLRDAGDRDLGLIEAVTLVVIFIILLI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 180 VFGTPLAALMPLLVGLITFIVAAGSLFFFAQN--MELSIFVLNAVAMIAIALGIDFSLLLVNRYREELTRGQSREEAIVR 257
Cdd:pfam03176 162 VYRSVVAALLPLLTVGLSLGAAQGLVAILAHIlgIGLSTFALNLLVVLLIAVGTDYALFLVSRYREELRAGEDREEAVIR 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 258 TVATAGRSILFSGLCVFVGLAGLLFIQVDVFQAVALGALIAVAGAVLSALTLLPSSLYLVGDAlnkgRIIKTDETKSEKR 337
Cdd:pfam03176 242 AVRGTGKVVTAAGLTVAIAMLALSFARLPVFAQVGPTIAIGVLVDVLAALTLLPALLALLGRW----GLWPPKRDRTARW 317
|
330
....*....|....
gi 2321701453 338 WQKLARFVMRRPVT 351
Cdd:pfam03176 318 WRRIGRLVVRRPAP 331
|
|
| actII |
TIGR00833 |
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ... |
10-694 |
1.32e-37 |
|
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 129913 [Multi-domain] Cd Length: 910 Bit Score: 150.89 E-value: 1.32e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 10 RFRYGVLLIW-AILLAGSVYFG-LQLPGELRGNGFAIQDG---RFQQVEDQLNERFDRAGASMIVLFEGGNLEA------ 78
Cdd:TIGR00833 1 RSAYGIIGVWiATAISLQLLAPlLEDVSYFRLQAELPGGAassIAVKEMSAAFQEAIRDPKIILVLESNERLGDkdyaty 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 79 ---VMDEQQDRFGEISSIDGVITPAENPDARSGDVS--YFVLEF---EDYDAAESSIDAVRdALIVDTDT----EVRLTG 146
Cdd:TIGR00833 81 dalIAKLRADIMHVISVVDFWGPPEAAEGLRSDDGKatIIIVNLageKGQKEAQEAINAVR-RIVEQTNApdglTVHVTG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 147 EPVFADDLNEASKNDLIRAELIGIPVALLVLLLVFGTPLAALMPLLVGLITFIVAAGSLFFFAQN--MELSIFVLNAVAM 224
Cdd:TIGR00833 160 PLATIADILESGDKDMNRITATTGIIVLIILLLVYRSPITMLVPLVSVGFSVVVAQGIVSLLGIPglIGVNAQTTVLLTA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 225 IAIALGIDFSLLLVNRYREELTRGQSREEAIVRTVATAGRSILFSGLCVFVGLAGLLFIQVDVFQAVALGALIAVAGAVL 304
Cdd:TIGR00833 240 LVIGAGTDYAVFLTGRYHEERRKGESLEEAAAEALRGTGKAILGSALTVAVAFLALSLARLPSFKTLGVSCAVGVLVALL 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 305 SALTLLPSSLYLVGDAlnkGRIIKTDETKSEKRWQKLARFVMRRPVTMTLIALLILLPSLWFVRDLELNIPDADALPTSY 384
Cdd:TIGR00833 320 NAVTLTPALLTLEGRE---GLMKPGRKSKIRFIWRRLGTAVVRRPWPILVTTLIISGVSLLALPLIRTGYDDEKMIPTDL 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 385 ESRAALERWDDVFGDNSTDAVLLF--EANDLTDPMILEELTSLIDELNEVDIVDNV------------------------ 438
Cdd:TIGR00833 397 ESVQGYEAADRHFPGNSMDPMVVMikSDHDVRNPALLADIDRFEREIKAVPGINMVqetqrpdgvvikktyltfqagnlg 476
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 439 ---STFLTTSGLTPETFTQLAEAAPEQLAPLERLVTL------------------------------------------- 472
Cdd:TIGR00833 477 dqlDEFSDQLTSRQAYLLQDAEKIAEAIAGLRLVQAGmrldgenlgqvslavrlmqqaisklqgsagdvfdifdplrrfv 556
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 --------------------------------------------------------------------------------
Cdd:TIGR00833 557 aaipecranpvcsvareivqaadtvvssaakladaagqlargiadvasalsqvsglpnaldgigtqlaqmresaagvqdl 636
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 473 -----------------DGNTDLALVNVSFDVPPSDKEAQAFVR------------------------------------ 499
Cdd:TIGR00833 637 lnelsdysmtmgklkgnAMGVDFYAPPRIFTDPNFKAVLDYFLSpdghaarllvygdgspagdqgaqefnairtvaeeai 716
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 500 ---DWRDKEFEVGGPAAFNEEIYDEIYDSIPYAVITVILATFFILMWAFRSILIPIKAILMNVLGLGATFGLLVIVFEsg 576
Cdd:TIGR00833 717 qraDLEPAKVELAGVSAVNRDLRDLVNSDLGLISIITLAIVFMILALLLRAPVAPIVLIGSVALSYLWALGLSVLAFQ-- 794
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 577 YVYDAETISiLTPVFIFSLVFGLSMDYEVFLVSRIEEYYREtgDNDYATEMGLAKTSKIITSAAIIMIVVTGAFAFTGVS 656
Cdd:TIGR00833 795 HILGAELHW-SVLAGVFVLLVALGVDYNMLLVSRIKEESPA--GNRTGIIRALGSTGGVITAAGLVFAGTMAALASAQLT 871
|
890 900 910
....*....|....*....|....*....|....*...
gi 2321701453 657 PIKQLGVGIALAIFIDATIIRILLVPSLMKLFGDWNWW 694
Cdd:TIGR00833 872 AIAQFGFTVGVGILLDTFIVRSVTVPALTLLLGRWIWW 909
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
141-687 |
9.75e-33 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 134.96 E-value: 9.75e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 141 EVRLTGEPVFADDLNEASKNDLIRAELIGIPVALLVLLLVFGTPLAALMPLLVGLITFIVAAGSLFFFAqnMELSIFVLN 220
Cdd:TIGR00921 174 FLDVTGSPAINYDIEREFGKDMGTTMAISGILVVLVLLLDFKRWWRPLLPLVIILFGVAWVLGIMGWLG--IPLYATTLL 251
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 221 AVAMIaIALGIDFSLLLVNRYREELTRGQSREEAIVRTVATAGRSILFSGLCVFVGLAGLLFIQVDVFQAVALGALIAVA 300
Cdd:TIGR00921 252 AVPML-IGVGIDYGIQTLNRYEEERDIGRAKGEAIVTAVRRTGRAVLIALLTTSAGFAALALSEFPMVSEFGLGLVAGLI 330
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 301 GAVLSALTLLPSSLYLV---GDALNKGRI-IKTDETKSEKRWQKLARFVMRRPVTMTLIALLILLPSLWFVRDLELNIPD 376
Cdd:TIGR00921 331 TAYLLTLLVLPALLQSIdigREKVKKEIIaIGGKSSEIEEELSKVLSITVRHPVPALVAALIITGLGLYGAAGIKPEVNI 410
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 377 ADALPTSYESRAALERWDDVFGDNSTDAVLLFEANDLTDPMILEELTSLIDELNEVDIVDNVSTFLTTSGL--TPETFTQ 454
Cdd:TIGR00921 411 EKFIPQDLPSLQARKVIESHMGGSHDFATILVKADDVRDPELVRFMDELSRDIKATGVAARVFGAPSIIDLvkEVEGLPA 490
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 455 LAEAAPEQLAPLERLVTLDGNtDLALVNVSFDVPPSDKEAQ--AFVRDWRDKEF------EVGGPAAFNEEIYDEIYDSI 526
Cdd:TIGR00921 491 PERSALEPIPEDEEGGYISGG-QIKVAVIQVQLKQGEPKVQgrKILRDVQHEHPppgvkvGVTGLPVAFAEMHELVNEGM 569
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 527 PYAVITVILATFFILMWAFRSILIPIKAILMNVLGLGATFGLLVIvfesgyvydAETISILTPVFIFSLVFGLSMDYEVF 606
Cdd:TIGR00921 570 RRMTIAGAILVLMILLAVFRNPIKAVFPLIAIGSGILWAIGLMGL---------RGIPSFLAMATTISIILGLGMDYSIH 640
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 607 LVSRIEEYYRETGDNDyATEMGLAKTSKIITSAAIIMIVVTGAFAFTGVSPIKQLGVGIALAIFIdATIIRILLVPSLMK 686
Cdd:TIGR00921 641 LAERYFEERKEHGPKE-AITHTMERTGPGILFSGLTTAGGFLSLLLSHFPIMRNFGLVQGIGVLS-SLTAALVVFPALLV 718
|
.
gi 2321701453 687 L 687
Cdd:TIGR00921 719 L 719
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
339-693 |
1.81e-32 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 134.22 E-value: 1.81e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 339 QKLARFVMRRPVTMTLIALLILLPSLWFVRDLELNIPDADALPTSYESRAALERWDDVFGdNSTDAVLLFEA-NDLTDPM 417
Cdd:COG1033 5 ERLARFILRHRKLVLLLFLLLTLLLAYGAPKLEVDTDFESLLPEDDPSVQAYDEFEEEFG-GDDTVVVAVEGkDDIFTPE 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 418 ILEELTSLIDELNEVDIVDNVS-------TFLTTSGL------------TPETFTQLAEAAPEQLAPLERLVTLDGNTdl 478
Cdd:COG1033 84 TLEALRELTEELEEIPGVDSVTsltnvraTEGTEDGLtveplipdelpaSPEELAELREKVLSSPLYVGRLVSPDGKA-- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 479 ALVNVSFDVPPSD-----KEAQAFVRDWRDK------EFEVGGPAAFNEEIYDEIYDSIPYAVITVILATFFILMWAFRS 547
Cdd:COG1033 162 TLIVVTLDPDPLSsdldrKEVVAEIRAIIAKyedpgvEVYLTGFPVLRGDIAEAIQSDLAIFFPLALLLILLLLFLFFRS 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 548 ILIPIKAILMNVLGLGATFGLLVIVfesGYvydaeTISILTpVFIFSLVFGLSMDYEVFLVSRIEEYYRETGDNDYATEM 627
Cdd:COG1033 242 LRGVLLPLLVVLLAVIWTLGLMGLL---GI-----PLSPLT-ILVPPLLLAIGIDYGIHLLNRYREERRKGLDKREALRE 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2321701453 628 GLAKTSKIITSAAIIMIVVTGAFAFTGVSPIKQLGVGIALAIFIdATIIRILLVPSLMKLFGDWNW 693
Cdd:COG1033 313 ALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLL-AFLTSLTLLPALLSLLPRPKP 377
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
1-325 |
3.98e-25 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 111.10 E-value: 3.98e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 1 MEWLGRQLVRFRYGVLLIWAILLAGSVYFGLQLPGELRGNGFAIQDGRFQQVEDQLNERFDRAGaSMIVLFEGGNLEAVM 80
Cdd:COG1033 392 LAKLARFVLRRPKVILVVALVLAVVSLYGISRLKVEYDFEDYLPEDSPIRQDLDFIEENFGGSD-PLEVVVDTGEPDGLK 470
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 81 D--------------EQQDRFGEISSIDGVITPAE---------------------------------------NPDARS 107
Cdd:COG1033 471 DpevlkeidrlqdylESLPEVGKVLSLADLVKELNqalnegdpkyyalpesrellaqlllllssppgddlsrfvDEDYSA 550
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 108 GDVSYFV--LEFEDYDAAESSIDAVRDALIVDTDTEVRLTGEPVFADDLNEASKNDLIRAELIGIPVALLVLLLVFGTPL 185
Cdd:COG1033 551 ARVTVRLkdLDSEEIKALVEEVRAFLAENFPPDGVEVTLTGSAVLFAAINESVIESQIRSLLLALLLIFLLLLLAFRSLR 630
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 186 AALMPLLVGLITFIVAAGSLFFFaqnmELSIFVLNA-VAMIAIALGIDFSLLLVNRYREELTRGQSREEAIVRTVATAGR 264
Cdd:COG1033 631 LGLISLIPNLLPILLTFGLMGLL----GIPLNIATAvVASIALGIGVDYTIHFLSRYREERRKGGDLEEAIRRALRTTGK 706
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2321701453 265 SILFSGLCVFVGLAGLLFIQVDVFQAVALGALIAVAGAVLSALTLLPSSLYLVGDALNKGR 325
Cdd:COG1033 707 AILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLLPALLLLLDPRIAKKR 767
|
|
| MMPL |
pfam03176 |
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ... |
507-694 |
1.88e-21 |
|
MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.
Pssm-ID: 308676 [Multi-domain] Cd Length: 332 Bit Score: 96.21 E-value: 1.88e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 507 EVGGPAAFNEEIYDEI-YDSIPYAVITVILAtFFILMWAFRSILIPIKAILMNVLGLGATFGLLVIVfesGYVyDAETIS 585
Cdd:pfam03176 125 YLTGPAATVADLRDAGdRDLGLIEAVTLVVI-FIILLIVYRSVVAALLPLLTVGLSLGAAQGLVAIL---AHI-LGIGLS 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 586 ILTPVFIFSLVFGLSMDYEVFLVSRIEEYYRETGDNDYATEMGLAKTSKIITSAAIIMIVVTGAFAFTGVSPIKQLGVGI 665
Cdd:pfam03176 200 TFALNLLVVLLIAVGTDYALFLVSRYREELRAGEDREEAVIRAVRGTGKVVTAAGLTVAIAMLALSFARLPVFAQVGPTI 279
|
170 180
....*....|....*....|....*....
gi 2321701453 666 ALAIFIDATIIRILLvPSLMKLFGDWNWW 694
Cdd:pfam03176 280 AIGVLVDVLAALTLL-PALLALLGRWGLW 307
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
346-692 |
3.74e-16 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 82.58 E-value: 3.74e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 346 MRRPVTMTLIALLILLPSLWFVRDLELNIPDADALPTSYESRAALERWDDVFGDNSTDAVLLFEANDLTDPMILEELTSL 425
Cdd:TIGR00921 1 MRFRTAIILVFLALLILSAYGAQHLNVESDTEKQLPKDFESYKWYHVLQREFGTSTKTLLVVIEGDDVTRKPVLDYMRRL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 426 IDELNEVDIVDNVSTF------LTTSGLTPETFTQLAEAAPEQLAPLERLVTLDGNTDLALVNVSfdvppSDKEAQAFVR 499
Cdd:TIGR00921 81 EQRLREKPYVTNVRSAadimrqIPGNFPLPVTMPEVRPLMSEYPRSKEMFLSKDHTVAIIIVQLK-----SDADYKQVVP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 500 DWRD-------------KEFEVGGPAAFNEEIYDEIYDSIPYAVITVILATFFILMWAFRSILIPIKAILMNVLGLGATF 566
Cdd:TIGR00921 156 IYNDverslertnppsgKFLDVTGSPAINYDIEREFGKDMGTTMAISGILVVLVLLLDFKRWWRPLLPLVIILFGVAWVL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 567 GLLVIVfesGYVYDAETISiltpvfIFSLVFGLSMDYEVFLVSRIEEYYRETGDNDYATEMGLAKTSKIITSAAIIMIVV 646
Cdd:TIGR00921 236 GIMGWL---GIPLYATTLL------AVPMLIGVGIDYGIQTLNRYEEERDIGRAKGEAIVTAVRRTGRAVLIALLTTSAG 306
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 2321701453 647 TGAFAFTGVSPIKQLGVGIALAIfIDATIIRILLVPSLMKLFGDWN 692
Cdd:TIGR00921 307 FAALALSEFPMVSEFGLGLVAGL-ITAYLLTLLVLPALLQSIDIGR 351
|
|
| HpnN |
TIGR03480 |
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ... |
43-499 |
4.41e-16 |
|
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.
Pssm-ID: 274598 [Multi-domain] Cd Length: 862 Bit Score: 82.35 E-value: 4.41e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 43 AIQDGRFQqvEDQLNERFDRAGASMivlfeggnlEAVMDEQQDRFGEISSIDGvitpaenPDARSGDVSYFV-----LEF 117
Cdd:TIGR03480 160 GLKAGQAQ--LPGLAPILDALAEAL---------RAFLEGKPAPFSWQALMSG-------KDAALAPRRRFIivqpvLDY 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 118 EDYDAAESSIDAVRDA-----LIVDTDTEVRLTGEPVFADDLNEASKNDLIRAELIGIPVALLVLLLVFGTP---LAALM 189
Cdd:TIGR03480 222 SSLEPAEKAINAIRAAakdlrLDEDHGVTVRLTGEVALSDEELATVSEGATVAGLLSFVLVLVLLWLALRSPrlvFAVLV 301
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 190 PLLVGLI-TFIVAA---GSLfffaqNMeLSIfvlnAVAMIAIALGIDFSLLLVNRYREELTRGQSREEAIVRTVATAGRS 265
Cdd:TIGR03480 302 TLIVGLIlTAAFATlavGHL-----NL-ISV----AFAVLFIGLGVDFAIQFSLRYREERFRGGNHREALSVAARRMGAA 371
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 266 ILFSGLCVFVGLagLLFIQVDvFQAVALGALIAVAG---AVLSALTLLPSSLYLVGDALNKgriiktdETKSEKRWQKLA 342
Cdd:TIGR03480 372 LLLAALATAAGF--FAFLPTD-YKGVSELGIIAGTGmfiALFVTLTVLPALLRLLRPPRRR-------KPPGYATLAPLD 441
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 343 RFVMRRP-----VTMTL-IALLILLPSLWFVRDLeLNIPDADAlptsyESRAALerwddvfgdnstdavLLFEANDLTDP 416
Cdd:TIGR03480 442 AFLRRHRrpvlgVTLILgIAALALLPQLRFDFNP-LNLQDPKT-----ESVRTF---------------LELLADPDTSP 500
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 417 MILEELTS-------LIDELNEVDIVDNVstfLTTSGLTPetftqlaEAAPEQLAPLERLVTLDGntDLALVNVSFDVPP 489
Cdd:TIGR03480 501 YSAEVLAPsapearaLTERLEALPEVDQV---VTLPDFVP-------DDQEAKLALIADLALVLG--PTLNPGEADPAPS 568
|
490
....*....|
gi 2321701453 490 SDKEAQAFVR 499
Cdd:TIGR03480 569 AEEVAAALRR 578
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
119-677 |
9.44e-09 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 58.71 E-value: 9.44e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 119 DYDAAESSIDAVRDA----LIVDTDTEVRLTGEPVFADDLNEASKNDLIRAELIGIPVALLVLLLVF---GTPLAALMPL 191
Cdd:COG4258 204 DTDAQQQLVAALRAAfaalNAAFPGAQLLLTGAGLFAVAAAQQIKHDISTIGLISLLGILLLLLLVFrslRPLLLGLLPV 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 192 LVGLITFIVAAGSLFffaqnMELSIFVLnAVAMIAIALGIDFSLLLVNRYREeltRGQSREEAIVRTVAtagRSILFSGL 271
Cdd:COG4258 284 AVGALAGLAAVSLVF-----GSVHGITL-GFGSSLIGVAVDYSLHYLTHRRA---AGEWDPRAALRRIW---PTLLLGLL 351
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 272 CVFVGLAGLLFIQVDVFQAVALGALIAVAGAVLSALTLLPSSL--YLVGDALNKGRIIKtdetKSEKRWQKLARFVMRRP 349
Cdd:COG4258 352 TTVLGYLALLFSPFPGLRQLGVFAAAGLLAAALTTLLWLPLLLprAAPRPPAPALALLA----RLLARWPRRLRWLLALL 427
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 350 VTMTLIALLILLPSLWfVRDLE-LNIPDADALptsyESRAALERwddVFGDNSTDAVLLFEANDLTDPMILEE-----LT 423
Cdd:COG4258 428 AVLALASLLGLNRLKW-NDDLRaLNPVPAALL----AQEARLRA---LLGAPDVSQYLVVYGPDAEQALQRNEallprLD 499
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 424 SLIDE-------------------------LNEVDIV-DNVSTFLTTSGLTPETFTQLAE--AAPEQLAPLER------- 468
Cdd:COG4258 500 ALVAQgaiagyqslsrllpsaatqqarqalLPDLAALrPRLAEALAGLGFRPDAFAPFLAdlEAARAAPPLTPedllasp 579
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 469 --------LVTLDGNTDLALVNVSfDVPPSDKEAQAFVRD----WRDKefevggpAAFNEEIYDEIYDSIPYAVITVILA 536
Cdd:COG4258 580 laaalrllLLGRKDGQWAALVPLR-GVDDAAALRAAAAGLpgvrLVDR-------KAESSSLFGRYRNDALWLLLLALLL 651
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 537 TFFILMWAFRSILIPIKAILMNVLGLGATFGLLVIVfesgyvydAETISILTpVFIFSLVFGLSMDYEVFLvsrieeyyr 616
Cdd:COG4258 652 ILLLLLLRLRSLRRALRVLLPPLLAVLLTLAILGLL--------GIPLNLFH-LIALLLVLGIGIDYALFF--------- 713
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2321701453 617 etgDNDYATEMGLAKTSKIITSAAIIMIVVTGAFAFTGVSPIKQLG----VGIALAIFIDATIIR 677
Cdd:COG4258 714 ---TEGLLDKGELARTLLSILLAALTTLLGFGLLAFSSTPALRSFGltvlLGILLALLLAPLLAP 775
|
|
| CusA |
COG3696 |
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism]; |
195-365 |
4.61e-05 |
|
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];
Pssm-ID: 442911 [Multi-domain] Cd Length: 1031 Bit Score: 46.95 E-value: 4.61e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 195 LITFIVaagslfFFAQNMELSIFVLnavAMIAIALGI--DFSLLLV-NRYR-----EELTRGQSREEAIVRTVATAGRSI 266
Cdd:COG3696 374 LFAFIV------MRLFGISANLMSL---GGLAIDFGIivDGAVVMVeNILRrleenRAAGTPRERLEVVLEAAREVRRPI 444
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 267 LFSGL---CVFV------GLAGLLFiqvdvfQAVALGALIAVAGAVLSALTLLP--SSLYLVGD-ALNKGRIIKtdetKS 334
Cdd:COG3696 445 FFATLiiiLVFLpiftleGVEGKLF------RPMALTVIFALLGALLLSLTLVPvlASLLLRGKvPEKENPLVR----WL 514
|
170 180 190
....*....|....*....|....*....|.
gi 2321701453 335 EKRWQKLARFVMRRPVTMTLIALLILLPSLW 365
Cdd:COG3696 515 KRLYRPLLRWALRHPKLVLAVALVLLVLALA 545
|
|
| ACR_tran |
pfam00873 |
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ... |
186-368 |
9.83e-05 |
|
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.
Pssm-ID: 395701 [Multi-domain] Cd Length: 1021 Bit Score: 45.75 E-value: 9.83e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 186 AALMPL----LVGLITFIvaagslffFAQNMELSIFVLNAVAM-IAIALGIDFSLLLV-NRYREELTRGQSREEAIVRTV 259
Cdd:pfam00873 357 ATLIPAiaipLSLLGTFA--------VMKAFGFSINTLTLGGLvLAIGLVVDDAIVVVeNIERVLEENGLKPLEAAYKSM 428
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 260 ATAGRSILFSGL---CVFVGLAGLLFIQVDVFQAVALGALIAVAGAVLSALTLLP--SSLYLVGDALNK-GRIIKTDET- 332
Cdd:pfam00873 429 GEIGGALVAIALvlsAVFLPILFLGGLTGRIFRQFAITIVLAILLSVLVALTLTPalCATLLKPRREPKhGGFFRWFNRm 508
|
170 180 190
....*....|....*....|....*....|....*....
gi 2321701453 333 --KSEKRWQKLARFVMRRPVTMTLIALLILLPSLW-FVR 368
Cdd:pfam00873 509 fdRLTRGYAKLLAKVLRHTAVVLLVALLLVVGSVWlFVR 547
|
|
| AcrB |
COG0841 |
Multidrug efflux pump subunit AcrB [Defense mechanisms]; |
191-367 |
4.47e-04 |
|
Multidrug efflux pump subunit AcrB [Defense mechanisms];
Pssm-ID: 440603 [Multi-domain] Cd Length: 1015 Bit Score: 43.55 E-value: 4.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 191 LLVGLI-TFIVaagsLFFFAQNMELSIFVLNAV-----AMIAIALGIDFSL-------------LLV----------NRY 241
Cdd:COG0841 337 LLEAILlVVLV----VFLFLRSWRATLIPAVAIpvsliGTFAVMYLLGFSLniltlfalvlaigIVVddaivvveniERH 412
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 242 REEltrGQSREEAIVRTVATAGRSILFSGLC---VFV------GLAGLLFIQVdvfqAVALGALIAVAGAVlsALTLLP- 311
Cdd:COG0841 413 MEE---GLSPLEAAIKGAREVAGAVIASTLTlvaVFLplafmgGITGQLFRQF----ALTVAIALLISLFV--ALTLTPa 483
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2321701453 312 --SSLYLVGDALNKGRIIKTDE---TKSEKRWQKLARFVMRRPVTMTLIALLILLPSLWFV 367
Cdd:COG0841 484 lcARLLKPHPKGKKGRFFRAFNrgfDRLTRGYGRLLRWALRHRKLTLLVALALLALSVLLF 544
|
|
| PRK09579 |
PRK09579 |
multidrug efflux RND transporter permease subunit; |
185-378 |
7.47e-04 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 169983 [Multi-domain] Cd Length: 1017 Bit Score: 42.90 E-value: 7.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 185 LAALMPLLVGLITFIVAAGSLFFFAQNMELSIFVLNAVAMI-AIALGIDFSLLLVNRYREELTRGQS---------REEA 254
Cdd:PRK09579 352 LGALRSVLIPVVTIPLSMIGVLFFMQMMGYSINLLTLLAMVlAIGLVVDDAIVVVENIHRHIEEGKSpfdaalegaREIA 431
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 255 IVRTVATAGRSILFSGLCVFVGLAGLLFIQVdvfqAVALGALIAVAGAVlsALTLLP--SSLYLVGDALNKGRIIKTDE- 331
Cdd:PRK09579 432 MPVVSMTITLAAVYAPIGFLTGLTGALFKEF----ALTLAGAVIISGIV--ALTLSPmmCALLLRHEENPSGLAHRLDRl 505
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 2321701453 332 -TKSEKRWQKLARFVMR-RPVTMTL-IALLILLPSLWFVRDLELnIPDAD 378
Cdd:PRK09579 506 fERLKQRYQRALHGTLNtRPVVLVFaVIVLALIPVLLKFTQSEL-APEED 554
|
|
| HpnN |
TIGR03480 |
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ... |
510-688 |
1.27e-03 |
|
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.
Pssm-ID: 274598 [Multi-domain] Cd Length: 862 Bit Score: 42.29 E-value: 1.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 510 GPAAFNEEIYDEIYDSIPYAVITVILATFFILMWAFRSILIPIKAILMNVLGLGATFGLLVIVfesgyVYDAETISI-LT 588
Cdd:TIGR03480 255 GEVALSDEELATVSEGATVAGLLSFVLVLVLLWLALRSPRLVFAVLVTLIVGLILTAAFATLA-----VGHLNLISVaFA 329
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 589 PVFIfslvfGLSMDYEVFLVSRIEEYYRETGDNDYATEMGLAKTSKIITSAAIIMIVVTGAFAFTGVSPIKQLG----VG 664
Cdd:TIGR03480 330 VLFI-----GLGVDFAIQFSLRYREERFRGGNHREALSVAARRMGAALLLAALATAAGFFAFLPTDYKGVSELGiiagTG 404
|
170 180
....*....|....*....|....
gi 2321701453 665 IALAIFIDATIIrillvPSLMKLF 688
Cdd:TIGR03480 405 MFIALFVTLTVL-----PALLRLL 423
|
|
| RND_permease_2 |
NF033617 |
multidrug efflux RND transporter permease subunit; |
186-366 |
3.38e-03 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 411236 [Multi-domain] Cd Length: 1009 Bit Score: 40.77 E-value: 3.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 186 AALMPLLVGLITFIvaagSLFFFAQNMELSIFVLNAVAM-IAIALGIDFSLLLVNRYREELTRGQSREEAIV---RTVAT 261
Cdd:NF033617 356 ATLIPAVTVPLSLI----GTFAVMYLFGFSINLLTLMALvLAIGLVVDDAIVVVENIHRHIEEGESPLEAALkgaREIGF 431
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321701453 262 AGRSILFSGLCVFV------GLAGLLFIQVdvfqAVALGALIAVAGAVlsALTLLP---SSLYLVGDALNK-GRIIKTDE 331
Cdd:NF033617 432 TVIAMTLTLVAVYLpilfmgGLTGRLFREF----AVTLAGAVIISGIV--ALTLTPmmcSRLLKANEKPGRfARAVDRFF 505
|
170 180 190
....*....|....*....|....*....|....*
gi 2321701453 332 TKSEKRWQKLARFVMRRPVTMTLIALLILLPSLWF 366
Cdd:NF033617 506 DGLTARYGRGLKWVLKHRPLTLVVALATLALLPLL 540
|
|
| |
