antigen I/II family LPXTG-anchored adhesin; Members of the antigen I/II family are adhesins ...
836-1253
8.29e-68
antigen I/II family LPXTG-anchored adhesin; Members of the antigen I/II family are adhesins with a glucan-binding domain, two types of repetitive regions, an isopeptide bond-forming domain associated with shear resistance, and a C-terminal LPXTG motif for anchoring to the cell wall. They occur in oral Streptococci, and tend to be major cell surface adhesins. Members of this family include SspA and SspB from Streptococcus gordonii, antigen I/II from S. mutans, etc.
The actual alignment was detected with superfamily member NF033804:
Pssm-ID: 468188 [Multi-domain] Cd Length: 1552 Bit Score: 251.78 E-value: 8.29e-68
antigen I/II family LPXTG-anchored adhesin; Members of the antigen I/II family are adhesins ...
416-755
2.18e-62
antigen I/II family LPXTG-anchored adhesin; Members of the antigen I/II family are adhesins with a glucan-binding domain, two types of repetitive regions, an isopeptide bond-forming domain associated with shear resistance, and a C-terminal LPXTG motif for anchoring to the cell wall. They occur in oral Streptococci, and tend to be major cell surface adhesins. Members of this family include SspA and SspB from Streptococcus gordonii, antigen I/II from S. mutans, etc.
The actual alignment was detected with superfamily member NF033804:
Pssm-ID: 468188 [Multi-domain] Cd Length: 1552 Bit Score: 234.45 E-value: 2.18e-62
MucBP domain; The MucBP (MUCin-Binding Protein) domain is found in a wide variety of bacterial ...
760-831
4.67e-05
MucBP domain; The MucBP (MUCin-Binding Protein) domain is found in a wide variety of bacterial proteins, in several repeats. The domain is found in bacterial peptidoglycan bound proteins and is often found in conjunction with pfam00746 and pfam00560.
:
Pssm-ID: 461917 [Multi-domain] Cd Length: 65 Bit Score: 42.33 E-value: 4.67e-05
MucBP domain; The MucBP (MUCin-Binding Protein) domain is found in a wide variety of bacterial ...
340-411
1.76e-04
MucBP domain; The MucBP (MUCin-Binding Protein) domain is found in a wide variety of bacterial proteins, in several repeats. The domain is found in bacterial peptidoglycan bound proteins and is often found in conjunction with pfam00746 and pfam00560.
:
Pssm-ID: 461917 [Multi-domain] Cd Length: 65 Bit Score: 40.79 E-value: 1.76e-04
MucBP domain; The MucBP (MUCin-Binding Protein) domain is found in a wide variety of bacterial ...
261-333
7.38e-04
MucBP domain; The MucBP (MUCin-Binding Protein) domain is found in a wide variety of bacterial proteins, in several repeats. The domain is found in bacterial peptidoglycan bound proteins and is often found in conjunction with pfam00746 and pfam00560.
:
Pssm-ID: 461917 [Multi-domain] Cd Length: 65 Bit Score: 39.25 E-value: 7.38e-04
antigen I/II family LPXTG-anchored adhesin; Members of the antigen I/II family are adhesins ...
836-1253
8.29e-68
antigen I/II family LPXTG-anchored adhesin; Members of the antigen I/II family are adhesins with a glucan-binding domain, two types of repetitive regions, an isopeptide bond-forming domain associated with shear resistance, and a C-terminal LPXTG motif for anchoring to the cell wall. They occur in oral Streptococci, and tend to be major cell surface adhesins. Members of this family include SspA and SspB from Streptococcus gordonii, antigen I/II from S. mutans, etc.
Pssm-ID: 468188 [Multi-domain] Cd Length: 1552 Bit Score: 251.78 E-value: 8.29e-68
antigen I/II family LPXTG-anchored adhesin; Members of the antigen I/II family are adhesins ...
416-755
2.18e-62
antigen I/II family LPXTG-anchored adhesin; Members of the antigen I/II family are adhesins with a glucan-binding domain, two types of repetitive regions, an isopeptide bond-forming domain associated with shear resistance, and a C-terminal LPXTG motif for anchoring to the cell wall. They occur in oral Streptococci, and tend to be major cell surface adhesins. Members of this family include SspA and SspB from Streptococcus gordonii, antigen I/II from S. mutans, etc.
Pssm-ID: 468188 [Multi-domain] Cd Length: 1552 Bit Score: 234.45 E-value: 2.18e-62
adhesin isopeptide-forming domain, sspB-C2 type; This domain has a conserved Lys (position 3 ...
417-590
8.36e-50
adhesin isopeptide-forming domain, sspB-C2 type; This domain has a conserved Lys (position 3 in seed alignment) and Asn at 177 that form an intramolecular isopeptide bond. The Asp (or Glu) at position 59
Pssm-ID: 275068 [Multi-domain] Cd Length: 173 Bit Score: 174.02 E-value: 8.36e-50
adhesin isopeptide-forming domain, sspB-C2 type; This domain has a conserved Lys (position 3 ...
837-1010
8.36e-50
adhesin isopeptide-forming domain, sspB-C2 type; This domain has a conserved Lys (position 3 in seed alignment) and Asn at 177 that form an intramolecular isopeptide bond. The Asp (or Glu) at position 59
Pssm-ID: 275068 [Multi-domain] Cd Length: 173 Bit Score: 174.02 E-value: 8.36e-50
LPXTG-anchored aggregation substance; Aggregation substances, as described in Enterococcus, ...
470-1254
4.93e-42
LPXTG-anchored aggregation substance; Aggregation substances, as described in Enterococcus, are LPXTG-anchored large surface proteins that contribute to virulence. Several closely related paralogs may be found in a single strain.
Pssm-ID: 411439 [Multi-domain] Cd Length: 1306 Bit Score: 168.74 E-value: 4.93e-42
Cell surface antigen C-terminus; This repeated domain is found at the C-terminus of cell ...
1013-1173
8.20e-30
Cell surface antigen C-terminus; This repeated domain is found at the C-terminus of cell surface antigens. In the Streptococcus mutans antigen I/II there are three repeats of this domain, a cleft between the first two of these forms a binding site for the human salivary agglutinin (SAG).
Pssm-ID: 435302 [Multi-domain] Cd Length: 171 Bit Score: 116.74 E-value: 8.20e-30
Cell surface antigen C-terminus; This repeated domain is found at the C-terminus of cell ...
593-753
4.38e-27
Cell surface antigen C-terminus; This repeated domain is found at the C-terminus of cell surface antigens. In the Streptococcus mutans antigen I/II there are three repeats of this domain, a cleft between the first two of these forms a binding site for the human salivary agglutinin (SAG).
Pssm-ID: 435302 [Multi-domain] Cd Length: 171 Bit Score: 109.03 E-value: 4.38e-27
LPXTG-anchored aggregation substance; Aggregation substances, as described in Enterococcus, ...
362-754
1.96e-23
LPXTG-anchored aggregation substance; Aggregation substances, as described in Enterococcus, are LPXTG-anchored large surface proteins that contribute to virulence. Several closely related paralogs may be found in a single strain.
Pssm-ID: 411439 [Multi-domain] Cd Length: 1306 Bit Score: 108.26 E-value: 1.96e-23
MucBP domain; The MucBP (MUCin-Binding Protein) domain is found in a wide variety of bacterial ...
760-831
4.67e-05
MucBP domain; The MucBP (MUCin-Binding Protein) domain is found in a wide variety of bacterial proteins, in several repeats. The domain is found in bacterial peptidoglycan bound proteins and is often found in conjunction with pfam00746 and pfam00560.
Pssm-ID: 461917 [Multi-domain] Cd Length: 65 Bit Score: 42.33 E-value: 4.67e-05
MucBP domain; The MucBP (MUCin-Binding Protein) domain is found in a wide variety of bacterial ...
340-411
1.76e-04
MucBP domain; The MucBP (MUCin-Binding Protein) domain is found in a wide variety of bacterial proteins, in several repeats. The domain is found in bacterial peptidoglycan bound proteins and is often found in conjunction with pfam00746 and pfam00560.
Pssm-ID: 461917 [Multi-domain] Cd Length: 65 Bit Score: 40.79 E-value: 1.76e-04
MucBP domain; The MucBP (MUCin-Binding Protein) domain is found in a wide variety of bacterial ...
261-333
7.38e-04
MucBP domain; The MucBP (MUCin-Binding Protein) domain is found in a wide variety of bacterial proteins, in several repeats. The domain is found in bacterial peptidoglycan bound proteins and is often found in conjunction with pfam00746 and pfam00560.
Pssm-ID: 461917 [Multi-domain] Cd Length: 65 Bit Score: 39.25 E-value: 7.38e-04
antigen I/II family LPXTG-anchored adhesin; Members of the antigen I/II family are adhesins ...
836-1253
8.29e-68
antigen I/II family LPXTG-anchored adhesin; Members of the antigen I/II family are adhesins with a glucan-binding domain, two types of repetitive regions, an isopeptide bond-forming domain associated with shear resistance, and a C-terminal LPXTG motif for anchoring to the cell wall. They occur in oral Streptococci, and tend to be major cell surface adhesins. Members of this family include SspA and SspB from Streptococcus gordonii, antigen I/II from S. mutans, etc.
Pssm-ID: 468188 [Multi-domain] Cd Length: 1552 Bit Score: 251.78 E-value: 8.29e-68
antigen I/II family LPXTG-anchored adhesin; Members of the antigen I/II family are adhesins ...
416-755
2.18e-62
antigen I/II family LPXTG-anchored adhesin; Members of the antigen I/II family are adhesins with a glucan-binding domain, two types of repetitive regions, an isopeptide bond-forming domain associated with shear resistance, and a C-terminal LPXTG motif for anchoring to the cell wall. They occur in oral Streptococci, and tend to be major cell surface adhesins. Members of this family include SspA and SspB from Streptococcus gordonii, antigen I/II from S. mutans, etc.
Pssm-ID: 468188 [Multi-domain] Cd Length: 1552 Bit Score: 234.45 E-value: 2.18e-62
adhesin isopeptide-forming domain, sspB-C2 type; This domain has a conserved Lys (position 3 ...
417-590
8.36e-50
adhesin isopeptide-forming domain, sspB-C2 type; This domain has a conserved Lys (position 3 in seed alignment) and Asn at 177 that form an intramolecular isopeptide bond. The Asp (or Glu) at position 59
Pssm-ID: 275068 [Multi-domain] Cd Length: 173 Bit Score: 174.02 E-value: 8.36e-50
adhesin isopeptide-forming domain, sspB-C2 type; This domain has a conserved Lys (position 3 ...
837-1010
8.36e-50
adhesin isopeptide-forming domain, sspB-C2 type; This domain has a conserved Lys (position 3 in seed alignment) and Asn at 177 that form an intramolecular isopeptide bond. The Asp (or Glu) at position 59
Pssm-ID: 275068 [Multi-domain] Cd Length: 173 Bit Score: 174.02 E-value: 8.36e-50
LPXTG-anchored aggregation substance; Aggregation substances, as described in Enterococcus, ...
470-1254
4.93e-42
LPXTG-anchored aggregation substance; Aggregation substances, as described in Enterococcus, are LPXTG-anchored large surface proteins that contribute to virulence. Several closely related paralogs may be found in a single strain.
Pssm-ID: 411439 [Multi-domain] Cd Length: 1306 Bit Score: 168.74 E-value: 4.93e-42
Cell surface antigen C-terminus; This repeated domain is found at the C-terminus of cell ...
1013-1173
8.20e-30
Cell surface antigen C-terminus; This repeated domain is found at the C-terminus of cell surface antigens. In the Streptococcus mutans antigen I/II there are three repeats of this domain, a cleft between the first two of these forms a binding site for the human salivary agglutinin (SAG).
Pssm-ID: 435302 [Multi-domain] Cd Length: 171 Bit Score: 116.74 E-value: 8.20e-30
Cell surface antigen C-terminus; This repeated domain is found at the C-terminus of cell ...
593-753
4.38e-27
Cell surface antigen C-terminus; This repeated domain is found at the C-terminus of cell surface antigens. In the Streptococcus mutans antigen I/II there are three repeats of this domain, a cleft between the first two of these forms a binding site for the human salivary agglutinin (SAG).
Pssm-ID: 435302 [Multi-domain] Cd Length: 171 Bit Score: 109.03 E-value: 4.38e-27
LPXTG-anchored aggregation substance; Aggregation substances, as described in Enterococcus, ...
362-754
1.96e-23
LPXTG-anchored aggregation substance; Aggregation substances, as described in Enterococcus, are LPXTG-anchored large surface proteins that contribute to virulence. Several closely related paralogs may be found in a single strain.
Pssm-ID: 411439 [Multi-domain] Cd Length: 1306 Bit Score: 108.26 E-value: 1.96e-23
Cell surface antigen I/II C2 terminal domain; This is the second domain (C2) located in the ...
417-585
9.64e-23
Cell surface antigen I/II C2 terminal domain; This is the second domain (C2) located in the C-terminal region found in antigen I/II type adhesin protein AspA from S. pyogenes. Together with C3, these two domains form an elongated structure, each domain adopts the DEv-IgG fold. Similar to the classical IgG folds, it is comprised of two major antiparallel beta-sheets, designated ABED and CFG. For the C2-domain, there are two additional strands on the CFG sheet. Furthermore, sheets ABED and CFG are interconnected by several cross-connecting loops and one alpha-helix (DH1). The side chains of D982 and N996 in the C2-domain are involved in hydrogen bonding with the side chains of R1264 and N1295 in the C3 domain. Main chain hydrogen bonding can also be observed between S992 in C2 and N1189/G1191 in C3, furthermore stabilizing the interaction between the domains. The C2 domain contains one bound metal ion, modeled as Ca2+, and both the C2- and C3-domains are stabilized by conserved isopeptide bonds, which connect the beta-sheets of the central DEv-IgG motifs.Other members of this family include Major cell-surface adhesin PAc from Streptococcus mutans and SspB from Streptococcus gordonii.
Pssm-ID: 465609 [Multi-domain] Cd Length: 180 Bit Score: 96.77 E-value: 9.64e-23
Cell surface antigen I/II C2 terminal domain; This is the second domain (C2) located in the ...
837-1005
9.64e-23
Cell surface antigen I/II C2 terminal domain; This is the second domain (C2) located in the C-terminal region found in antigen I/II type adhesin protein AspA from S. pyogenes. Together with C3, these two domains form an elongated structure, each domain adopts the DEv-IgG fold. Similar to the classical IgG folds, it is comprised of two major antiparallel beta-sheets, designated ABED and CFG. For the C2-domain, there are two additional strands on the CFG sheet. Furthermore, sheets ABED and CFG are interconnected by several cross-connecting loops and one alpha-helix (DH1). The side chains of D982 and N996 in the C2-domain are involved in hydrogen bonding with the side chains of R1264 and N1295 in the C3 domain. Main chain hydrogen bonding can also be observed between S992 in C2 and N1189/G1191 in C3, furthermore stabilizing the interaction between the domains. The C2 domain contains one bound metal ion, modeled as Ca2+, and both the C2- and C3-domains are stabilized by conserved isopeptide bonds, which connect the beta-sheets of the central DEv-IgG motifs.Other members of this family include Major cell-surface adhesin PAc from Streptococcus mutans and SspB from Streptococcus gordonii.
Pssm-ID: 465609 [Multi-domain] Cd Length: 180 Bit Score: 96.77 E-value: 9.64e-23
LPXTG-motif cell wall anchor domain; This model describes the LPXTG motif-containing region ...
1220-1253
4.65e-05
LPXTG-motif cell wall anchor domain; This model describes the LPXTG motif-containing region found at the C-terminus of many surface proteins of Streptococcus and Streptomyces species. Cleavage between the Thr and Gly by sortase or a related enzyme leads to covalent anchoring at the new C-terminal Thr to the cell wall. Hits that do not lie at the C-terminus or are not found in Gram-positive bacteria are probably false-positive. A common feature of this proteins containing this domain appears to be a high proportion of charged and zwitterionic residues immediatedly upstream of the LPXTG motif. This model differs from other descriptions of the LPXTG region by including a portion of that upstream charged region. [Cell envelope, Other]
Pssm-ID: 273478 [Multi-domain] Cd Length: 34 Bit Score: 41.69 E-value: 4.65e-05
MucBP domain; The MucBP (MUCin-Binding Protein) domain is found in a wide variety of bacterial ...
760-831
4.67e-05
MucBP domain; The MucBP (MUCin-Binding Protein) domain is found in a wide variety of bacterial proteins, in several repeats. The domain is found in bacterial peptidoglycan bound proteins and is often found in conjunction with pfam00746 and pfam00560.
Pssm-ID: 461917 [Multi-domain] Cd Length: 65 Bit Score: 42.33 E-value: 4.67e-05
MucBP domain; The MucBP (MUCin-Binding Protein) domain is found in a wide variety of bacterial ...
340-411
1.76e-04
MucBP domain; The MucBP (MUCin-Binding Protein) domain is found in a wide variety of bacterial proteins, in several repeats. The domain is found in bacterial peptidoglycan bound proteins and is often found in conjunction with pfam00746 and pfam00560.
Pssm-ID: 461917 [Multi-domain] Cd Length: 65 Bit Score: 40.79 E-value: 1.76e-04
MucBP domain; The MucBP (MUCin-Binding Protein) domain is found in a wide variety of bacterial ...
261-333
7.38e-04
MucBP domain; The MucBP (MUCin-Binding Protein) domain is found in a wide variety of bacterial proteins, in several repeats. The domain is found in bacterial peptidoglycan bound proteins and is often found in conjunction with pfam00746 and pfam00560.
Pssm-ID: 461917 [Multi-domain] Cd Length: 65 Bit Score: 39.25 E-value: 7.38e-04
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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of your query sequence and the protein sequences used to curate the domain model,
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Functional characterization of the conserved domain architecture found on the query.
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if a domain or superfamily has been annotated with functional sites (conserved features),
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The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
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To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page,
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Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence.
(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
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