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Conserved domains on  [gi|2351829481|ref|WP_266761447|]
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MULTISPECIES: Lrp/AsnC family transcriptional regulator [unclassified Streptomyces]

Protein Classification

Lrp/AsnC family transcriptional regulator( domain architecture ID 11445815)

Lrp/AsnC (leucine-responsive regulatory protein/asparagine synthase C) family transcriptional regulator regulates many cellular processes such as amino acid metabolism, pili synthesis, and DNA repair and recombination

CATH:  3.30.70.920|1.10.10.10
Gene Ontology:  GO:0043565
PubMed:  16438681|21608015|27206730

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
1-136 4.13e-46

DNA-binding transcriptional regulator, Lrp family [Transcription];


:

Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 146.85  E-value: 4.13e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2351829481   1 MDAVDRQLIQALRENGRASYAELGRLVGLSGPSVTDRINRLEAAGVITGYRATVDSASLGLGVTALIGISLsDAADHEDV 80
Cdd:COG1522     3 LDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKV-PPHRLDEF 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2351829481  81 ARRLRDLSEIEDCWFIAGDDSFMLKVRSSDVDGLEKTI-RRLSGTKGVSRTRTTIVL 136
Cdd:COG1522    82 AEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLlERLAALPGVRRTETSFVL 138
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
1-136 4.13e-46

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 146.85  E-value: 4.13e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2351829481   1 MDAVDRQLIQALRENGRASYAELGRLVGLSGPSVTDRINRLEAAGVITGYRATVDSASLGLGVTALIGISLsDAADHEDV 80
Cdd:COG1522     3 LDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKV-PPHRLDEF 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2351829481  81 ARRLRDLSEIEDCWFIAGDDSFMLKVRSSDVDGLEKTI-RRLSGTKGVSRTRTTIVL 136
Cdd:COG1522    82 AEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLlERLAALPGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 1-107 3.16e-35

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 118.00  E-value: 3.16e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2351829481    1 MDAVDRQLIQALRENGRASYAELGRLVGLSGPSVTDRINRLEAAGVITGYRATVDSASLGLGVTALIGISLSDAADHEDV 80
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLENPDKLEEF 80

                           90       100
                   ....*....|....*....|....*..
gi 2351829481   81 ARRLRDLSEIEDCWFIAGDDSFMLKVR 107
Cdd:smart00344  81 LEKLEKLPEVEEVYLVTGDYDYLLKVR 107
PRK11179 PRK11179
DNA-binding transcriptional regulator AsnC; Provisional
 1-136 1.07e-22

DNA-binding transcriptional regulator AsnC; Provisional


Pssm-ID: 183019 [Multi-domain]  Cd Length: 153  Bit Score: 87.46  E-value: 1.07e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2351829481   1 MDAVDRQLIQALRENGRASYAELGRLVGLSGPSVTDRINRLEAAGVITGYRATVDSASLGLGVTALIGISLSDAADHEDV 80
Cdd:PRK11179    7 IDNLDRGILEALMENARTPYAELAKQFGVSPGTIHVRVEKMKQAGIITGTRVDVNPKQLGYDVCCFIGIILKSAKDYPSA 86

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2351829481  81 ARRLRDLSEIEDCWFIAGDDSFMLKVRSSDVDGLEKT-IRRLSGTKGVSRTRTTIVL 136
Cdd:PRK11179   87 LAKLESLDEVVEAYYTTGHYSIFIKVMCRSIDALQHVlINKIQTIDEIQSTETLISL 143
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 67-138 2.18e-17

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 71.40  E-value: 2.18e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2351829481  67 IGISLSDAADHEDVARRLRDLSEIEDCWFIAGDDSFMLKVRSSDVDGLEKTIRR-LSGTKGVSRTRTTIVLST 138
Cdd:pfam01037   1 VEVKLEPGHALEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREkLRSLPGVARTETSIVLST 73
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 2-52 5.56e-05

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 39.20  E-value: 5.56e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2351829481   2 DAVDRQLIQALRENGRaSYAELGRLVGLSGPSVTDRINRLEAAGVITGYRA 52
Cdd:cd00090     6 DPTRLRILRLLLEGPL-TVSELAERLGLSQSTVSRHLKKLEEAGLVESRRE 55
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
1-136 4.13e-46

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 146.85  E-value: 4.13e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2351829481   1 MDAVDRQLIQALRENGRASYAELGRLVGLSGPSVTDRINRLEAAGVITGYRATVDSASLGLGVTALIGISLsDAADHEDV 80
Cdd:COG1522     3 LDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKV-PPHRLDEF 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2351829481  81 ARRLRDLSEIEDCWFIAGDDSFMLKVRSSDVDGLEKTI-RRLSGTKGVSRTRTTIVL 136
Cdd:COG1522    82 AEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLlERLAALPGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 1-107 3.16e-35

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 118.00  E-value: 3.16e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2351829481    1 MDAVDRQLIQALRENGRASYAELGRLVGLSGPSVTDRINRLEAAGVITGYRATVDSASLGLGVTALIGISLSDAADHEDV 80
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLENPDKLEEF 80

                           90       100
                   ....*....|....*....|....*..
gi 2351829481   81 ARRLRDLSEIEDCWFIAGDDSFMLKVR 107
Cdd:smart00344  81 LEKLEKLPEVEEVYLVTGDYDYLLKVR 107
PRK11179 PRK11179
DNA-binding transcriptional regulator AsnC; Provisional
 1-136 1.07e-22

DNA-binding transcriptional regulator AsnC; Provisional


Pssm-ID: 183019 [Multi-domain]  Cd Length: 153  Bit Score: 87.46  E-value: 1.07e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2351829481   1 MDAVDRQLIQALRENGRASYAELGRLVGLSGPSVTDRINRLEAAGVITGYRATVDSASLGLGVTALIGISLSDAADHEDV 80
Cdd:PRK11179    7 IDNLDRGILEALMENARTPYAELAKQFGVSPGTIHVRVEKMKQAGIITGTRVDVNPKQLGYDVCCFIGIILKSAKDYPSA 86

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2351829481  81 ARRLRDLSEIEDCWFIAGDDSFMLKVRSSDVDGLEKT-IRRLSGTKGVSRTRTTIVL 136
Cdd:PRK11179   87 LAKLESLDEVVEAYYTTGHYSIFIKVMCRSIDALQHVlINKIQTIDEIQSTETLISL 143
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
1-136 8.83e-22

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 85.58  E-value: 8.83e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2351829481   1 MDAVDRQLIQALRENGRASYAELGRLVGLSGPSVTDRINRLEAAGVITGYRATVDSASLGLGVTALIGISLS-DAAD-HE 78
Cdd:PRK11169   12 LDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLNrGAPDvFE 91

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2351829481  79 DVARRLRDLSEIEDCWFIAGDDSFMLKVRSSDVdgleKTIRRLSGTK-----GVSRTRTTIVL 136
Cdd:PRK11169   92 QFNAAVQKLEEIQECHLVSGDFDYLLKTRVPDM----SAYRKLLGETllrlpGVNDTRTYVVM 150
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 67-138 2.18e-17

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 71.40  E-value: 2.18e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2351829481  67 IGISLSDAADHEDVARRLRDLSEIEDCWFIAGDDSFMLKVRSSDVDGLEKTIRR-LSGTKGVSRTRTTIVLST 138
Cdd:pfam01037   1 VEVKLEPGHALEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREkLRSLPGVARTETSIVLST 73
HTH_AsnC-type pfam13404
AsnC-type helix-turn-helix domain;
2-42 6.61e-13

AsnC-type helix-turn-helix domain;


Pssm-ID: 433180 [Multi-domain]  Cd Length: 41  Bit Score: 58.92  E-value: 6.61e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2351829481   2 DAVDRQLIQALRENGRASYAELGRLVGLSGPSVTDRINRLE 42
Cdd:pfam13404   1 DEIDRKILRLLQEDARISFAELAERVGLSESTVLRRIRRLE 41
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
5-47 3.41e-10

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 52.05  E-value: 3.41e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2351829481   5 DRQLIQALRENGRASYAELGRLVGLSGPSVTDRINRLEAAGVI 47
Cdd:pfam13412   3 DRKILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 2-52 5.56e-05

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 39.20  E-value: 5.56e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2351829481   2 DAVDRQLIQALRENGRaSYAELGRLVGLSGPSVTDRINRLEAAGVITGYRA 52
Cdd:cd00090     6 DPTRLRILRLLLEGPL-TVSELAERLGLSQSTVSRHLKKLEEAGLVESRRE 55
LexA COG1974
SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, ...
 3-107 3.01e-04

SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, Signal transduction mechanisms];


Pssm-ID: 441577 [Multi-domain]  Cd Length: 199  Bit Score: 39.13  E-value: 3.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2351829481   3 AVDRQLIQALRENGRA-SYAELGRLVGLSGPSVTDRINRLEAAGVITGYRATVDSASLGLGVTALIGISL---------S 72
Cdd:COG1974    10 EILDFIKEYIRERGYPpSQREIAEALGLSSSAVHRHLKALEKKGYLRRDPGKSRAIELLPASPEVVGLPLlgrvaagfpI 89

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2351829481  73 DAADHedVARRLrdlsEIEDCWFIAGDDSFMLKVR 107
Cdd:COG1974    90 PAEEN--IEEYL----DLPEELVKNPGATFALRVK 118
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
12-91 3.90e-03

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 34.88  E-value: 3.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2351829481   12 LRENGRASYAELGRLVGLSGPSVTDRINRLEAAGVITGYRATVDSASLGLGVT----ALigISLSDAADHEDVARRLRDL 87
Cdd:smart00347  19 LYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTeegrEL--IEQLLEARSETLAELLAGL 96


                   ....
gi 2351829481   88 SEIE 91
Cdd:smart00347  97 TAEE 100
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
2-48 6.34e-03

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 35.28  E-value: 6.34e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2351829481   2 DAVDRQLIQALRENGRASYAELGRLVGLSGPSVTDRINRLEAAGVIT 48
Cdd:COG2345    12 DPTRRRILELLKRAGPVTAAELAEALGLTPNAVRRHLDALEEEGLVE 58
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 1-55 6.46e-03

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 33.33  E-value: 6.46e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2351829481   1 MDAVDRQLIQALRENGRASYAELGRLVGLSGPSVTDRINRLEAAGVITGYRATVD 55
Cdd:pfam12802   3 LTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPAD 57
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
7-48 6.82e-03

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 34.95  E-value: 6.82e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2351829481   7 QLIQALRENGRASYAELGRLVGLSGPSVTDRINRLEAAGVIT 48
Cdd:COG1846    42 RVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVE 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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