|
Name |
Accession |
Description |
Interval |
E-value |
| RsuA |
COG1187 |
Pseudouridylate synthase RsuA, specific for 16S rRNA U516 and 23S rRNA U2605 [Translation, ... |
35-261 |
3.59e-101 |
|
Pseudouridylate synthase RsuA, specific for 16S rRNA U516 and 23S rRNA U2605 [Translation, ribosomal structure and biogenesis]; Pseudouridylate synthase RsuA, specific for 16S rRNA U516 and 23S rRNA U2605 is part of the Pathway/BioSystem: 16S rRNA modification
Pssm-ID: 440800 [Multi-domain] Cd Length: 226 Bit Score: 295.40 E-value: 3.59e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316514 35 SERLQKVMAAAGVASRRVSEQLIAQGRVTVNGVVVDELGARIEPSvDELAVDGVAVQLDGTRRYVMLNKPTGVVSTLRDE 114
Cdd:COG1187 2 GMRLQKFLANAGVGSRREAEELIEAGRVTVNGKVVTELGTKVDPG-DEVTVDGKPLKLPEEPVYLLLNKPAGVVSTTKDP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316514 115 NGRPDLRQF-TDRFDDRLFNVGRLDADTSGLLLLTNDGALANVLAHPRFGVEKTYIATVKGGVTGQALRRLREGVELEDG 193
Cdd:COG1187 81 EGRPTVFDLlPEARKERLFPVGRLDKDTEGLLLLTNDGELAHRLTHPKYGVEKEYLVRVDGPVTEEDLERLREGVELEDG 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2388316514 194 VAIADKARLLGepSKGRSMVELTLHSGRNRVVRRMMAEVGFPVIELVRRQFGPLHLGTLPIGRTRPLT 261
Cdd:COG1187 161 PTKPAKVEILS--GEANTWLRITLTEGRNRQVRRMFEAVGLPVVRLKRVRIGPLTLGDLPPGEWRELT 226
|
|
| PseudoU_synth_RsuA_like |
cd02870 |
Pseudouridine synthases, RsuA subfamily; Pseudouridine synthases are responsible for the ... |
98-244 |
4.43e-64 |
|
Pseudouridine synthases, RsuA subfamily; Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this family are bacterial proteins.
Pssm-ID: 211347 [Multi-domain] Cd Length: 146 Bit Score: 198.10 E-value: 4.43e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316514 98 YVMLNKPTGVVSTLRDENGRPDLRQFTDRFDDRLFNVGRLDADTSGLLLLTNDGALANVLAHPRFGVEKTYIATVKGGVT 177
Cdd:cd02870 1 YLLLNKPRGVVSTVRDPEGRPTVLDLLKDVGERLFPVGRLDYDTEGLLLLTNDGELANRLTHPRYGVEKTYLVKVRGVPS 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2388316514 178 GQALRRLREGVELEDGVAIADKARLLgEPSKGRSMVELTLHSGRNRVVRRMMAEVGFPVIELVRRQF 244
Cdd:cd02870 81 EEELRRLRAGVELDDGKTAPAKVKVL-SRDPKNTLLEVTLHEGRNRQVRRMFEAVGHPVLRLKRVRI 146
|
|
| TIGR00093 |
TIGR00093 |
pseudouridine synthase; This model identifies panels of pseudouridine synthase enzymes that ... |
134-261 |
1.73e-42 |
|
pseudouridine synthase; This model identifies panels of pseudouridine synthase enzymes that RNA modifications involved in maturing the protein translation apparatus. Counts per genome vary: two in Staphylococcus aureus, three in Pseudomonas putida, four in E. coli, etc. [Protein synthesis, tRNA and rRNA base modification]
Pssm-ID: 272902 Cd Length: 128 Bit Score: 142.47 E-value: 1.73e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316514 134 VGRLDADTSGLLLLTNDGALANVLAHPRFGVEKTYIATVKGGVTGQALRRLREGVELEDGVAIADKARLLGEPsKGRSMV 213
Cdd:TIGR00093 1 VGRLDRDSEGLLLLTNDGELVHRLTHPGHHHEKEYLVTVEGPVTDEDLEALRKGVQLEDGKTKPAKLKVITEP-GFPTWL 79
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 2388316514 214 ELTLHSGRNRVVRRMMAEVGFPVIELVRRQFGPLHLGTLPIGRTRPLT 261
Cdd:TIGR00093 80 RVTLSEGRNRQVRRMFAAVGFPVLRLHRVRIGDVSLNGLPPGEWRPLT 127
|
|
| PRK10700 |
PRK10700 |
23S rRNA pseudouridine(2605) synthase RluB; |
35-258 |
4.94e-36 |
|
23S rRNA pseudouridine(2605) synthase RluB;
Pssm-ID: 182659 [Multi-domain] Cd Length: 289 Bit Score: 130.66 E-value: 4.94e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316514 35 SERLQKVMAAAGVASRRVSEQLIAQGRVTVNGVVVdELGARIEPSVD-ELAVDGVAVQLDGTR----RYVMLNKPTGVVS 109
Cdd:PRK10700 2 SEKLQKVLARAGHGSRREIESIIEAGRVSVDGKIA-TLGDRVEVTPGlKIRIDGHLISVKESAeqicRVLAYYKPEGELC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316514 110 TLRDENGRPDLRQFTDRFDD-RLFNVGRLDADTSGLLLLTNDGALANVLAHPRFGVEKTYIATVKGGVTGQALRRLREGV 188
Cdd:PRK10700 81 TRNDPEGRPTVFDRLPKLRGaRWIAVGRLDVNTCGLLLFTTDGELANRLMHPSREVEREYAVRVFGQVDDAKLRQLSRGV 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2388316514 189 ELEDGVAIADKARLLGepSKG-RSMVELTLHSGRNRVVRRMMAEVGFPVIELVRRQFGPLhlgTLPIGRTR 258
Cdd:PRK10700 161 QLEDGPAAFKTIKFSG--GEGiNQWYNVTLTEGRNREVRRLWEAVGVQVSRLIRVRYGDI---PLPKGLPR 226
|
|
| PseudoU_synth_2 |
pfam00849 |
RNA pseudouridylate synthase; Members of this family are involved in modifying bases in RNA ... |
98-230 |
2.14e-21 |
|
RNA pseudouridylate synthase; Members of this family are involved in modifying bases in RNA molecules. They carry out the conversion of uracil bases to pseudouridine. This family includes RluD, a pseudouridylate synthase that converts specific uracils to pseudouridine in 23S rRNA. RluA from E. coli converts bases in both rRNA and tRNA.
Pssm-ID: 459961 [Multi-domain] Cd Length: 151 Bit Score: 87.85 E-value: 2.14e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316514 98 YVMLNKPTGVVSTLRDENGRPDLRQFTDRF----DDRLFNVGRLDADTSGLLLLTNDGALANVLAH--PRFGVEKTYIAT 171
Cdd:pfam00849 1 YIVVNKPAGVPVHPTDSLTKLLSLLALLLRrelgVKRLYPVHRLDKNTSGLLLLAKDGEAANKLNKlfPERKIEKEYLAL 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2388316514 172 VKGGVTGQAlrRLREGVELEDGVAIADKARLLGEPSK-------------GRSMVELTLHSGRNRVVRRMMA 230
Cdd:pfam00849 81 VDKPEEEEG--TIKSPIKKEKNKSPFRKEEELGGKKAvthlkvlksgskgDYSLLELELVTGRKHQIRAHLA 150
|
|
| S4 |
smart00363 |
S4 RNA-binding domain; |
37-87 |
2.65e-06 |
|
S4 RNA-binding domain;
Pssm-ID: 214638 [Multi-domain] Cd Length: 60 Bit Score: 44.12 E-value: 2.65e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 2388316514 37 RLQKVMAAAG-VASRRVSEQLIAQGRVTVNGVVVDELGARIEPSvDELAVDG 87
Cdd:smart00363 2 RLDKFLARLGlAPSRSQARRLIEQGRVKVNGKKVTKPSYIVKPG-DVISVRG 52
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| RsuA |
COG1187 |
Pseudouridylate synthase RsuA, specific for 16S rRNA U516 and 23S rRNA U2605 [Translation, ... |
35-261 |
3.59e-101 |
|
Pseudouridylate synthase RsuA, specific for 16S rRNA U516 and 23S rRNA U2605 [Translation, ribosomal structure and biogenesis]; Pseudouridylate synthase RsuA, specific for 16S rRNA U516 and 23S rRNA U2605 is part of the Pathway/BioSystem: 16S rRNA modification
Pssm-ID: 440800 [Multi-domain] Cd Length: 226 Bit Score: 295.40 E-value: 3.59e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316514 35 SERLQKVMAAAGVASRRVSEQLIAQGRVTVNGVVVDELGARIEPSvDELAVDGVAVQLDGTRRYVMLNKPTGVVSTLRDE 114
Cdd:COG1187 2 GMRLQKFLANAGVGSRREAEELIEAGRVTVNGKVVTELGTKVDPG-DEVTVDGKPLKLPEEPVYLLLNKPAGVVSTTKDP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316514 115 NGRPDLRQF-TDRFDDRLFNVGRLDADTSGLLLLTNDGALANVLAHPRFGVEKTYIATVKGGVTGQALRRLREGVELEDG 193
Cdd:COG1187 81 EGRPTVFDLlPEARKERLFPVGRLDKDTEGLLLLTNDGELAHRLTHPKYGVEKEYLVRVDGPVTEEDLERLREGVELEDG 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2388316514 194 VAIADKARLLGepSKGRSMVELTLHSGRNRVVRRMMAEVGFPVIELVRRQFGPLHLGTLPIGRTRPLT 261
Cdd:COG1187 161 PTKPAKVEILS--GEANTWLRITLTEGRNRQVRRMFEAVGLPVVRLKRVRIGPLTLGDLPPGEWRELT 226
|
|
| PseudoU_synth_RsuA_like |
cd02870 |
Pseudouridine synthases, RsuA subfamily; Pseudouridine synthases are responsible for the ... |
98-244 |
4.43e-64 |
|
Pseudouridine synthases, RsuA subfamily; Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this family are bacterial proteins.
Pssm-ID: 211347 [Multi-domain] Cd Length: 146 Bit Score: 198.10 E-value: 4.43e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316514 98 YVMLNKPTGVVSTLRDENGRPDLRQFTDRFDDRLFNVGRLDADTSGLLLLTNDGALANVLAHPRFGVEKTYIATVKGGVT 177
Cdd:cd02870 1 YLLLNKPRGVVSTVRDPEGRPTVLDLLKDVGERLFPVGRLDYDTEGLLLLTNDGELANRLTHPRYGVEKTYLVKVRGVPS 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2388316514 178 GQALRRLREGVELEDGVAIADKARLLgEPSKGRSMVELTLHSGRNRVVRRMMAEVGFPVIELVRRQF 244
Cdd:cd02870 81 EEELRRLRAGVELDDGKTAPAKVKVL-SRDPKNTLLEVTLHEGRNRQVRRMFEAVGHPVLRLKRVRI 146
|
|
| PseudoU_synth_RsuA |
cd02553 |
Pseudouridine synthase, Escherichia coli RsuA like; This group is comprised of eukaryotic and ... |
97-265 |
2.31e-44 |
|
Pseudouridine synthase, Escherichia coli RsuA like; This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. E.coli RsuA makes psi516 in 16S RNA. Psi at this position is not generally conserved in other organisms.
Pssm-ID: 211327 [Multi-domain] Cd Length: 167 Bit Score: 148.44 E-value: 2.31e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316514 97 RYVMLNKPTGVVSTLRDENGRP--DLRQFTDRFDDrLFNVGRLDADTSGLLLLTNDGALANVLAHPRFGVEKTYIATVKG 174
Cdd:cd02553 1 VYLMLNKPAGVVCATKDPHHPTviDLLPEPDRRRD-LFPVGRLDKDTTGLLLLTNDGQLAHRLTSPKKHVPKTYEVTLAG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316514 175 GVTGQALRRLREGVELEDG-VAIADKARLLGEpskgrSMVELTLHSGRNRVVRRMMAEVGFPVIELVRRQFGPLHLG-TL 252
Cdd:cd02553 80 PLTEDDIEAFAEGVLLHDGyPTKPAKLEILSP-----TTVRLTITEGKYHQVKRMFAAVGNKVVALHRIRIGGLELDdDL 154
|
170
....*....|...
gi 2388316514 253 PIGRTRPLTKDEL 265
Cdd:cd02553 155 APGEWRPLTEEEL 167
|
|
| TIGR00093 |
TIGR00093 |
pseudouridine synthase; This model identifies panels of pseudouridine synthase enzymes that ... |
134-261 |
1.73e-42 |
|
pseudouridine synthase; This model identifies panels of pseudouridine synthase enzymes that RNA modifications involved in maturing the protein translation apparatus. Counts per genome vary: two in Staphylococcus aureus, three in Pseudomonas putida, four in E. coli, etc. [Protein synthesis, tRNA and rRNA base modification]
Pssm-ID: 272902 Cd Length: 128 Bit Score: 142.47 E-value: 1.73e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316514 134 VGRLDADTSGLLLLTNDGALANVLAHPRFGVEKTYIATVKGGVTGQALRRLREGVELEDGVAIADKARLLGEPsKGRSMV 213
Cdd:TIGR00093 1 VGRLDRDSEGLLLLTNDGELVHRLTHPGHHHEKEYLVTVEGPVTDEDLEALRKGVQLEDGKTKPAKLKVITEP-GFPTWL 79
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 2388316514 214 ELTLHSGRNRVVRRMMAEVGFPVIELVRRQFGPLHLGTLPIGRTRPLT 261
Cdd:TIGR00093 80 RVTLSEGRNRQVRRMFAAVGFPVLRLHRVRIGDVSLNGLPPGEWRPLT 127
|
|
| PseudoU_synth_RluE |
cd02566 |
Pseudouridine synthase, Escherichia coli RluE; This group is comprised of bacterial proteins ... |
98-252 |
2.36e-42 |
|
Pseudouridine synthase, Escherichia coli RluE; This group is comprised of bacterial proteins similar to E. coli RluE. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. Escherichia coli RluE makes psi2457 in 23S RNA. psi2457 is not universally conserved.
Pssm-ID: 211334 [Multi-domain] Cd Length: 168 Bit Score: 143.29 E-value: 2.36e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316514 98 YVMLNKPTGVVSTLRDEN-GRPDLRQFTDrfDDRLFNVGRLDADTSGLLLLTNDGALANVLAHPRFGVEKTYIATVKGGV 176
Cdd:cd02566 1 LILFNKPYGVLSQFTDESeKHKTLKDYID--DPGVYAAGRLDRDSEGLLLLTDDGRLQHRITDPSFKHPKTYYVQVEGVP 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316514 177 TGQALRRLREGVELEDGVAIADKARLLGEP--------------SKGRSMVELTLHSGRNRVVRRMMAEVGFPVIELVRR 242
Cdd:cd02566 79 TEDALEQLRNGVELGDGLTLPAKVEKVDEPpwlwereppirfrkNIPTSWIEITICEGKNRQVRRMTAAVGFPTLRLIRV 158
|
170
....*....|
gi 2388316514 243 QFGPLHLGTL 252
Cdd:cd02566 159 SIGDIGLDNL 168
|
|
| PseudoU_synth_RluB |
cd02556 |
Pseudouridine synthase, Escherichia coli RluB like; This group is comprised of bacterial and ... |
97-262 |
9.78e-38 |
|
Pseudouridine synthase, Escherichia coli RluB like; This group is comprised of bacterial and eukaryotic proteins similar to E. coli RluB. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. E.coli RluB makes psi2605 in 23S RNA. psi2605 has been detected in eubacteria but, not in eukarya and archea despite the presence of a precursor U at that site.
Pssm-ID: 211330 [Multi-domain] Cd Length: 167 Bit Score: 131.28 E-value: 9.78e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316514 97 RYVMLNKPTGVVSTLRDENGRPDLrqftdrFD-------DRLFNVGRLDADTSGLLLLTNDGALANVLAHPRFGVEKTYI 169
Cdd:cd02556 1 RVLIYHKPEGLICTRKDPKGRPTV------FDllpklgiPRWISVGRLDLNTEGLLLFTNDGELANRLMHPSNEIEREYA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316514 170 ATVKGGVTGQALRRLREGVELEDGVAIADKARLLGEPSKGrSMVELTLHSGRNRVVRRMMAEVGFPVIELVRRQFGPLHL 249
Cdd:cd02556 75 VRVFGQVTDEQLKSLKKGVELEDGFAGFKSIQLEGGEGKN-SWYRVTLREGRNREVRRLWEAFGLQVSRLIRIRYGPIFL 153
|
170
....*....|....
gi 2388316514 250 -GTLPIGRTRPLTK 262
Cdd:cd02556 154 pGNLKRGQWEELPP 167
|
|
| PRK10700 |
PRK10700 |
23S rRNA pseudouridine(2605) synthase RluB; |
35-258 |
4.94e-36 |
|
23S rRNA pseudouridine(2605) synthase RluB;
Pssm-ID: 182659 [Multi-domain] Cd Length: 289 Bit Score: 130.66 E-value: 4.94e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316514 35 SERLQKVMAAAGVASRRVSEQLIAQGRVTVNGVVVdELGARIEPSVD-ELAVDGVAVQLDGTR----RYVMLNKPTGVVS 109
Cdd:PRK10700 2 SEKLQKVLARAGHGSRREIESIIEAGRVSVDGKIA-TLGDRVEVTPGlKIRIDGHLISVKESAeqicRVLAYYKPEGELC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316514 110 TLRDENGRPDLRQFTDRFDD-RLFNVGRLDADTSGLLLLTNDGALANVLAHPRFGVEKTYIATVKGGVTGQALRRLREGV 188
Cdd:PRK10700 81 TRNDPEGRPTVFDRLPKLRGaRWIAVGRLDVNTCGLLLFTTDGELANRLMHPSREVEREYAVRVFGQVDDAKLRQLSRGV 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2388316514 189 ELEDGVAIADKARLLGepSKG-RSMVELTLHSGRNRVVRRMMAEVGFPVIELVRRQFGPLhlgTLPIGRTR 258
Cdd:PRK10700 161 QLEDGPAAFKTIKFSG--GEGiNQWYNVTLTEGRNREVRRLWEAVGVQVSRLIRVRYGDI---PLPKGLPR 226
|
|
| PseudoU_synth_RluF |
cd02554 |
Pseudouridine synthase, Escherichia coli RluF like; This group is comprised of bacterial ... |
98-265 |
1.66e-34 |
|
Pseudouridine synthase, Escherichia coli RluF like; This group is comprised of bacterial proteins similar to Escherichia coli RluF. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. E.coli RluF makes psi2604 in 23S RNA. psi2604 has only been detected in E. coli. It is absent from other eubacteria despite a precursor U at that site and from eukarya and archea which lack a precursor U at that site.
Pssm-ID: 211328 [Multi-domain] Cd Length: 164 Bit Score: 122.80 E-value: 1.66e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316514 98 YVMLNKPTGVVSTLRDENgRPDLRQFTDRFDdRLFNVGRLDADTSGLLLLTNDGALANVLAHPRFGVEKTYIATVKGGVT 177
Cdd:cd02554 2 YIAYNKPVGIDCTLERAD-EDNIIDFVNPPP-RIFPIGRLDKDSEGLILLTNDGDLVNKILHADNNHEKEYLVTVNKPIT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316514 178 GQALRRLREGVELEDGVAIADKARLLGEPSkgrsmVELTLHSGRNRVVRRMMAEVGFPVIELVRRQFGPLHLGTLPIGRT 257
Cdd:cd02554 80 DEFIEGMSNGVVILGTVTKPCKVERLAKDK-----FRIVLTQGLNRQIRRMCEALGYRVTDLKRVRIMNIELGDLAPGEW 154
|
....*...
gi 2388316514 258 RPLTKDEL 265
Cdd:cd02554 155 RPLTDAEL 162
|
|
| PseudoU_synth_Rsu_Rlu_like |
cd02550 |
Pseudouridine synthase, Rsu/Rlu family; This group is comprised of eukaryotic, bacterial and ... |
98-241 |
5.43e-31 |
|
Pseudouridine synthase, Rsu/Rlu family; This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and TruA. Pseudouridine synthases catalyze the isomerization of specific uridines in a n RNA molecule to pseudouridines (5-ribosyluracil, psi) requiring no cofactors. E. coli RluC for example makes psi955, 2504 and 2580 in 23S RNA. Some psi sites such as psi1917 in 23S RNA made by RluD are universally conserved. Other psi sites occur in a more restricted fashion, for example psi2819 in 21S mitochondrial ribosomal RNA made by S. cerevisiae Pus5p is only found in mitochondrial large subunit rRNAs from some other species and in gram negative bacteria. The E. coli counterpart of this psi residue is psi2580 in 23S rRNA. psi2604in 23S RNA made by RluF has only been detected in E.coli.
Pssm-ID: 211325 [Multi-domain] Cd Length: 154 Bit Score: 113.24 E-value: 5.43e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316514 98 YVMLNKPTGVVSTLRDENGRPDLRQFTDRFD-DRLFNVGRLDADTSGLLLLTNDGALANVLAHPRFGVEKTYIATVKGGV 176
Cdd:cd02550 1 ILVLNKPSGLVCHPTDRDRDPTVVVRLDKLHgPRVHAAGRLDKDTSGLLLLTNDGRLQRRLTEPRREIEKEYLVTVRGEL 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2388316514 177 TGQALRRLRE-------GVELEDGVAIADKARLLGePSKGRSMVELTLHSGRNRVVRRMMAEVGFPVIELVR 241
Cdd:cd02550 81 DEEGIEDLATvrrgrlsGLVDEGVPLAVTKVRVIG-EHGGTGRLRLTLKTGRTHQIRRHCAAVGFPVLRLHR 151
|
|
| PRK10475 |
PRK10475 |
23S rRNA pseudouridine(2604) synthase RluF; |
32-292 |
1.44e-30 |
|
23S rRNA pseudouridine(2604) synthase RluF;
Pssm-ID: 236698 [Multi-domain] Cd Length: 290 Bit Score: 115.98 E-value: 1.44e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316514 32 SATSERLQKVMAAAGVASRRVSEQLIAQGRVTVNGVVVdELGARIEPSvDELAVDGvavQLDGTRR-----YVMLNKPTG 106
Cdd:PRK10475 3 TDSSTRLNKYISESGICSRREADRYIEQGNVFINGKRA-TIGDQVKAG-DVVKVNG---QLIEPREaedlvLIALNKPVG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316514 107 VVSTLrDENGRPDLRQFTdRFDDRLFNVGRLDADTSGLLLLTNDGALANVLAHPRFGVEKTYIATVKGGVTGQALRRLRE 186
Cdd:PRK10475 78 IVSTT-EDGERDNIVDFV-NHSKRVFPIGRLDKDSQGLIFLTNHGDLVNKILRAGNDHEKEYLVTVDKPITDEFIRGMGA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316514 187 GVELedgvaiadkarlLGEPSKgRSMVE--------LTLHSGRNRVVRRMMAEVGFPVIELVRRQFGPLHLGTLPIGRTR 258
Cdd:PRK10475 156 GVPI------------LGTVTK-KCKVKkeapfvfrITLVQGLNRQIRRMCEHFGYEVTKLERTRIMNVSLSGIPLGEWR 222
|
250 260 270
....*....|....*....|....*....|....
gi 2388316514 259 PLTKDELGALLTLGRDARAEGAGDGVEPTDADGA 292
Cdd:PRK10475 223 DLTDDELIDLFKLIENSSSEAKPKAKAKPKTAGI 256
|
|
| PRK10839 |
PRK10839 |
16S rRNA pseudouridine(516) synthase RsuA; |
37-265 |
1.76e-29 |
|
16S rRNA pseudouridine(516) synthase RsuA;
Pssm-ID: 236774 [Multi-domain] Cd Length: 232 Bit Score: 111.74 E-value: 1.76e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316514 37 RLQKVMAAAGVASRRVSEQLIAQGRVTVNGVVVDELGARIEPSvDELAVDGVAVQLDGTRRYVMLNKPTG-VVSTlrDEN 115
Cdd:PRK10839 2 RLDKFISQQLGVSRAIAGRELRANRVTVDGEIVKNGAFKLLPE-HDVAYDGNPLAQQHGPRYFMLNKPQGyVCST--DDP 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316514 116 GRPDLRQFTDR-FDDRLFNVGRLDADTSGLLLLTNDGALANVLAHPRFGVEKTYIATVKGGVTGQALRRLREGVELEDGV 194
Cdd:PRK10839 79 DHPTVLYFLDEpVAYKLHAAGRLDIDTTGLVLMTDDGQWSHRITSPRHHCEKTYLVTLESPVADDTAEQFAKGVQLHNEK 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2388316514 195 AIADKARL-LGEPSKgrsmVELTLHSGRNRVVRRMMAEVGFPVIELVRRQFGPLHL-GTLPIGRTRPLTKDEL 265
Cdd:PRK10839 159 DLTKPAVLeVITPTQ----VRLTISEGRYHQVKRMFAAVGNHVVELHRERIGAITLdADLAPGEYRPLTEEEI 227
|
|
| PRK11394 |
PRK11394 |
23S rRNA pseudouridine(2457) synthase RluE; |
97-261 |
4.18e-28 |
|
23S rRNA pseudouridine(2457) synthase RluE;
Pssm-ID: 183115 Cd Length: 217 Bit Score: 107.90 E-value: 4.18e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316514 97 RYVMLNKPTGVVSTLRDENGRPDLRQFTDRfdDRLFNVGRLDADTSGLLLLTNDGALANVLAHPRFGVEKTYIATVKGGV 176
Cdd:PRK11394 40 RVILFNKPYDVLPQFTDEAGRKTLKEFIPV--QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIP 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316514 177 TGQALRRLREGVELEDGVAIADKARLLGEP--------------SKGRSMVELTLHSGRNRVVRRMMAEVGFPVIELVRR 242
Cdd:PRK11394 118 TQDALEALRNGVTLNDGPTLPAGAELVDEPawlwprnppirerkSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRY 197
|
170
....*....|....*....
gi 2388316514 243 QFGPLHLGTLPIGRTRPLT 261
Cdd:PRK11394 198 AMGDYSLDNLANGEWREAT 216
|
|
| PseudoU_synth_2 |
pfam00849 |
RNA pseudouridylate synthase; Members of this family are involved in modifying bases in RNA ... |
98-230 |
2.14e-21 |
|
RNA pseudouridylate synthase; Members of this family are involved in modifying bases in RNA molecules. They carry out the conversion of uracil bases to pseudouridine. This family includes RluD, a pseudouridylate synthase that converts specific uracils to pseudouridine in 23S rRNA. RluA from E. coli converts bases in both rRNA and tRNA.
Pssm-ID: 459961 [Multi-domain] Cd Length: 151 Bit Score: 87.85 E-value: 2.14e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316514 98 YVMLNKPTGVVSTLRDENGRPDLRQFTDRF----DDRLFNVGRLDADTSGLLLLTNDGALANVLAH--PRFGVEKTYIAT 171
Cdd:pfam00849 1 YIVVNKPAGVPVHPTDSLTKLLSLLALLLRrelgVKRLYPVHRLDKNTSGLLLLAKDGEAANKLNKlfPERKIEKEYLAL 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2388316514 172 VKGGVTGQAlrRLREGVELEDGVAIADKARLLGEPSK-------------GRSMVELTLHSGRNRVVRRMMA 230
Cdd:pfam00849 81 VDKPEEEEG--TIKSPIKKEKNKSPFRKEEELGGKKAvthlkvlksgskgDYSLLELELVTGRKHQIRAHLA 150
|
|
| PSSA_1 |
cd02555 |
Pseudouridine synthase, a subgroup of the RsuA family; This group is comprised of bacterial ... |
99-264 |
5.49e-17 |
|
Pseudouridine synthase, a subgroup of the RsuA family; This group is comprised of bacterial proteins assigned to the RsuA family of pseudouridine synthases. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. The TruA family is comprised of proteins related to Escherichia coli RsuA.
Pssm-ID: 211329 [Multi-domain] Cd Length: 177 Bit Score: 77.06 E-value: 5.49e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316514 99 VMLNKPTGVVS----TLRDENGRPDLRQFTDRFDDRLFN----VGRLDADTSGLLLLTNDGALANVLAHPRFGVEKTYIA 170
Cdd:cd02555 7 LLLHKPAGMVSeqalALLGPGQRSAADRSGRRPLKGHFArlapIGPLDKDASGLLVFSQDGRVLRKLIGDASRLEQEYLV 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316514 171 TVKGGVTGQALRRLREGVELEDGVAIADKARLLGEpskgrSMVELTLHSGRNRVVRRMMAEVGFPVIELVRRQFGPLHLG 250
Cdd:cd02555 87 EVRGELTAGGLERLNHGLTYDGRELPPAKVSWQNE-----QRLRFALKEPQPGQIRRMCESVGLEVVALRRIRIGRVSLG 161
|
170
....*....|....
gi 2388316514 251 TLPIGRTRPLTKDE 264
Cdd:cd02555 162 KLPLGQWRYLTTGE 175
|
|
| S4 |
cd00165 |
S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, ... |
36-102 |
8.99e-10 |
|
S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized functional similarity between these three protein classes.
Pssm-ID: 238095 [Multi-domain] Cd Length: 70 Bit Score: 53.79 E-value: 8.99e-10
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2388316514 36 ERLQKVMAAAG-VASRRVSEQLIAQGRVTVNGVVVDELGARIEPSvDELAVDGVAVQLD---GTRRYVMLN 102
Cdd:cd00165 1 MRLDKILARLGlAPSRSEARQLIKHGHVLVNGKVVTKPSYKVKPG-DVIEVDGKSIEEDivyEDKKLLVVN 70
|
|
| PRK11112 |
PRK11112 |
tRNA pseudouridine synthase C; Provisional |
99-237 |
1.42e-09 |
|
tRNA pseudouridine synthase C; Provisional
Pssm-ID: 182971 [Multi-domain] Cd Length: 257 Bit Score: 57.37 E-value: 1.42e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316514 99 VMLNKPTG---------------VVSTLRDENGRpdlrqftdrfddRLFNVGRLDADTSGLLLLTNDGALANVLAhPRFG 163
Cdd:PRK11112 12 VAVNKPAGwlvhrswldrhetvfVMQTVRDQIGQ------------HVFTAHRLDRPTSGVLLMALSSEVARLLA-QQFE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316514 164 ---VEKTYIATVKGGVTGQALRRLREGVELEDgvaIADK-ARLLGEP-----------------SKGR------SMVELT 216
Cdd:PRK11112 79 qhqIQKTYHAIVRGWLMEEAVLDYPLKEELDK---IADKfAREDKAPqpavthyrglatvempvATGRypttrySLVELE 155
|
170 180
....*....|....*....|.
gi 2388316514 217 LHSGRNRVVRRMMAEVGFPVI 237
Cdd:PRK11112 156 PKTGRKHQLRRHMAHLRHPII 176
|
|
| PseudoU_synth_RluA_like |
cd02869 |
Pseudouridine synthase, RluA family; This group is comprised of eukaryotic, bacterial and ... |
101-237 |
2.11e-09 |
|
Pseudouridine synthase, RluA family; This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and TruA. Pseudouridine synthases catalyze the isomerization of specific uridines in a n RNA molecule to pseudouridines (5-ribosyluracil, psi) requiring no cofactors. E. coli RluC for example makes psi955, 2504 and 2580 in 23S RNA. Some psi sites such as psi1917 in 23S RNA made by RluD are universally conserved. Other psi sites occur in a more restricted fashion, for example psi2819 in 21S mitochondrial ribosomal RNA made by S. cerevisiae Pus5p is only found in mitochondrial large subunit rRNAs from some other species and in gram negative bacteria. The E. coli counterpart of this psi residue is psi2580 in 23S rRNA. psi2604in 23S RNA made by RluF has only been detected in E.coli.
Pssm-ID: 211346 [Multi-domain] Cd Length: 185 Bit Score: 55.81 E-value: 2.11e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316514 101 LNKPTGVVSTLRDENGRPDLRQFTDRFDD------RLFNVGRLDADTSGLLLLTNdgalaNVLAHPRFG-------VEKT 167
Cdd:cd02869 4 VNKPAGLPVHPGPGHLTGTLVNALLKLLLllgeefRPGLVHRLDKDTSGLLLVAK-----NKKAAAKLSkqfkerkVKKT 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316514 168 YIATVKG------GVTGQALRRLREGVELEDGVAIADKA-----RLLgEPSKGRSMVELTLHSGRNRVVRRMMAEVGFPV 236
Cdd:cd02869 79 YLALVDGkppedeGTIDAPLGRKKRKKRARVVVSEDGKPaithyKVL-ERFGNVTLVELQLETGRTHQIRVHLASIGHPI 157
|
.
gi 2388316514 237 I 237
Cdd:cd02869 158 V 158
|
|
| PseudoU_synth_TruC |
cd02563 |
tRNA pseudouridine isomerase C; Pseudouridine synthases catalyze the isomerization of specific ... |
97-237 |
2.00e-08 |
|
tRNA pseudouridine isomerase C; Pseudouridine synthases catalyze the isomerization of specific uridines in an tRNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. TruC makes psi65 in tRNAs. This psi residue is not universally conserved.
Pssm-ID: 211333 [Multi-domain] Cd Length: 223 Bit Score: 53.49 E-value: 2.00e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316514 97 RYVMLNKPTGVVsTLRDENGRPDLR---QFT-DRFDDRLFNVGRLDADTSGLLLLTNDGALANVL--AHPRFGVEKTYIA 170
Cdd:cd02563 9 HLVAINKPSGLL-VHRSELDRHETRfalQTLrDQLGQHVYPVHRLDRPTSGVLLFALSSEVARKLgeQFTEHRVHKTYLA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316514 171 TVKGGVTGQAL--RRLREGV-ELEDGVAIADKA--------RLLGE----------PSKGRSMVELTLHSGRNRVVRRMM 229
Cdd:cd02563 88 VVRGYVPESGTidYPLSEELdKLADKFASDDKApqaatthyRLLAVeelpvvvgkyPTSRYSLVELTPHTGRKHQLRRHL 167
|
....*...
gi 2388316514 230 AEVGFPVI 237
Cdd:cd02563 168 AHIRHPII 175
|
|
| S4 |
pfam01479 |
S4 domain; The S4 domain is a small domain consisting of 60-65 amino acid residues that was ... |
36-79 |
1.26e-07 |
|
S4 domain; The S4 domain is a small domain consisting of 60-65 amino acid residues that was detected in the bacterial ribosomal protein S4, eukaryotic ribosomal S9, two families of pseudouridine synthases, a novel family of predicted RNA methylases, a yeast protein containing a pseudouridine synthetase and a deaminase domain, bacterial tyrosyl-tRNA synthetases, and a number of uncharacterized, small proteins that may be involved in translation regulation. The S4 domain probably mediates binding to RNA.
Pssm-ID: 396182 [Multi-domain] Cd Length: 48 Bit Score: 47.49 E-value: 1.26e-07
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 2388316514 36 ERLQKVMAAAGVA-SRRVSEQLIAQGRVTVNGVVVDELGARIEPS 79
Cdd:pfam01479 1 RRLDKVLARLGLAsSRSQARQLIEHGRVLVNGKVVKDPSYRVKPG 45
|
|
| rluA_subfam |
TIGR00005 |
pseudouridine synthase, RluA family; In E. coli, RluD (SfhB) modifies uridine to pseudouridine ... |
34-236 |
4.98e-07 |
|
pseudouridine synthase, RluA family; In E. coli, RluD (SfhB) modifies uridine to pseudouridine at 23S RNA U1911, 1915, and 1917, RluC modifies 955, 2504 and 2580, and RluA modifies U746 and tRNA U32. An additional homolog from E. coli outside this family, TruC (SP|Q46918), modifies uracil-65 in transfer RNAs to pseudouridine. [Protein synthesis, tRNA and rRNA base modification]
Pssm-ID: 161659 [Multi-domain] Cd Length: 299 Bit Score: 50.01 E-value: 4.98e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316514 34 TSERLQKVMAAA-GVASRRVSEQLIAQGRVTVNGVVVDEL------GARIEPSVDELAVDGVAVQL--------DgtRRY 98
Cdd:TIGR00005 4 AGQRLDDFLASLlPDLSRSRIQKLIENGQVKVNGKVTANPklkvkdGDRITVRVPEEEEHEVPPQDipldilfeD--EDI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316514 99 VMLNKPTGVVS-------------TLRDENGRPDLRQftdrfddRLFNVGRLDADTSGLLLLT-NDGALANVLAHPRF-G 163
Cdd:TIGR00005 82 IVINKPSGLVVhpgggnpfgtvlnALLAHCPPIAGVE-------RVGIVHRLDRDTSGLMVVAkTPLALRELQRQLKNrT 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316514 164 VEKTYIATVKG------GVTGQALRRLReGVELEDGVAIADKA-------RLLgEPSKGRSMVELTLHSGRNRVVRRMMA 230
Cdd:TIGR00005 155 VTKEYVALVHGqfdsggGTVDAPLGRVP-NNRGLMAVHPSSEGkpavthfRVL-ERFGNASLVECELETGRTHQIRVHLQ 232
|
....*.
gi 2388316514 231 EVGFPV 236
Cdd:TIGR00005 233 YLGHPL 238
|
|
| S4 |
smart00363 |
S4 RNA-binding domain; |
37-87 |
2.65e-06 |
|
S4 RNA-binding domain;
Pssm-ID: 214638 [Multi-domain] Cd Length: 60 Bit Score: 44.12 E-value: 2.65e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 2388316514 37 RLQKVMAAAG-VASRRVSEQLIAQGRVTVNGVVVDELGARIEPSvDELAVDG 87
Cdd:smart00363 2 RLDKFLARLGlAPSRSQARRLIEQGRVKVNGKKVTKPSYIVKPG-DVISVRG 52
|
|
| RluA |
COG0564 |
Pseudouridine synthase RluA, 23S rRNA- or tRNA-specific [Translation, ribosomal structure and ... |
101-237 |
3.49e-06 |
|
Pseudouridine synthase RluA, 23S rRNA- or tRNA-specific [Translation, ribosomal structure and biogenesis]; Pseudouridine synthase RluA, 23S rRNA- or tRNA-specific is part of the Pathway/BioSystem: 23S rRNA modification
Pssm-ID: 440330 [Multi-domain] Cd Length: 218 Bit Score: 47.05 E-value: 3.49e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316514 101 LNKPTGVVsTLRDENGRPD------LRQFTDRFDD-RLFNVGRLDADTSGLLLLT-NDGA---LANVLAHPRfgVEKTYI 169
Cdd:COG0564 11 VNKPAGLV-VHPGSGGDDGtlvnalRAHLGELSGVpRPGLVHRLDRDTSGLLLVAkTRKAarrLSEQFRERE--VEKRYL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316514 170 ATVKG------GVTGQALRRLREG-----VELEDG-VAIADkARLLGEpSKGRSMVELTLHSGRNRVVRRMMAEVGFPVI 237
Cdd:COG0564 88 ALVEGkpkedeGTIDAPLGRDPKDrkkmaVVDEDGkPAVTH-YRVLER-FGGYSLVEVRLETGRTHQIRVHLAHIGHPIV 165
|
|
| PseudoU_synth_ScRIB2 |
cd02557 |
Pseudouridine synthases similar to Saccharomyces cerevisiae RIB2; Pseudouridine synthase, ... |
75-174 |
3.02e-04 |
|
Pseudouridine synthases similar to Saccharomyces cerevisiae RIB2; Pseudouridine synthase, Saccharomyces cerevisiae RIB2_like. This group is comprised of eukaryotic and bacterial proteins similar to Saccharomyces cerevisiae RIB2, S. cerevisiae Pus6p and human hRPUDSD2. S. cerevisiae RIB2 displays two distinct catalytic activities. The N-terminal domain of RIB2 is RNA:psi-synthase which makes psi32 on cytoplasmic tRNAs. Psi32 is highly phylogenetically conserved. The C-terminal domain of RIB2 has a DRAP deaminase activity which catalyses the formation of 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphate from 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate during riboflavin biosynthesis. S. cerevisiae Pus6p makes the psi31 of cytoplasmic and mitochondrial tRNAs.
Pssm-ID: 211331 [Multi-domain] Cd Length: 213 Bit Score: 41.08 E-value: 3.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316514 75 RIEPSVDELAVDgvAVQLDGTrrYVMLNKPTG-------------VVSTLRDENGRpdlrqftdrfdDRLFNVGRLDADT 141
Cdd:cd02557 6 RHEPPVTNDPIK--IVHEDDD--LLVVDKPSGipvhptgryryntVTEILKSEYGL-----------TELRPCHRLDRLT 70
|
90 100 110
....*....|....*....|....*....|....*
gi 2388316514 142 SGLLLLTNDGALA-NVLAHPRFG-VEKTYIATVKG 174
Cdd:cd02557 71 SGLLLFAKTSQTAsRLQQQIRSReVKKEYLARVKG 105
|
|
| |
