NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2388316544|ref|WP_267737498|]
View 

TlyA family RNA methyltransferase [Microcella daejeonensis]

Protein Classification

TlyA family RNA methyltransferase( domain architecture ID 11439687)

TlyA family RNA methyltransferase similar to Mycobacterium tuberculosis 16S/23S rRNA (cytidine-2'-O)-methyltransferase and Bacillus subtilis rRNA methyltransferase YqxC

CATH:  3.40.50.150
Gene Ontology:  GO:0008168|GO:0032259|GO:0003723
PubMed:  12826405|12504684

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
YqxC COG1189
Predicted rRNA methylase YqxC, contains S4 and FtsJ domains [Translation, ribosomal structure ...
5-255 6.43e-100

Predicted rRNA methylase YqxC, contains S4 and FtsJ domains [Translation, ribosomal structure and biogenesis];


:

Pssm-ID: 440802 [Multi-domain]  Cd Length: 248  Bit Score: 292.35  E-value: 6.43e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316544   5 MRLDAALVQLGLARSRALARAAIEQGRVSVDGRAIVKPAHPVADGARIVVEGEDH-YVSRAAHKLIAALDAAAIDSSGML 83
Cdd:COG1189     1 ERLDVLLVERGLAESREKAQRLIMAGRVLVNGQVVDKPGTKVPEDAEIEVKGEELpYVSRGGLKLEGALDAFGIDVAGKV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316544  84 CLDLGASTGGFTQVLLERGAARVVALDVGHGQLAPSIALDPRVVSVEGENARALTAERLaavsgiAERPQLVVGDLSFIP 163
Cdd:COG1189    81 CLDIGASTGGFTDCLLQRGAAKVYAVDVGYGQLAWKLRQDPRVVVLERTNARYLTPEDL------PEPPDLVVIDVSFIS 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316544 164 LRLILPAIVATAAPEAPIILLVKPQFEVGRTGV-REGVVRDPALREDAIMGVLWAAYDLGLLAERVDSSPVLGTSGNHEY 242
Cdd:COG1189   155 LTLVLPALLALLKPGGELVALVKPQFEVGRERVgKGGVVRDPALHAEVIEKVLAAAAELGLRVLGLTPSPITGPDGNIEF 234
                         250
                  ....*....|...
gi 2388316544 243 LAVFRPGAGEHPT 255
Cdd:COG1189   235 LLWLRKGGGPDPD 247
 
Name Accession Description Interval E-value
YqxC COG1189
Predicted rRNA methylase YqxC, contains S4 and FtsJ domains [Translation, ribosomal structure ...
5-255 6.43e-100

Predicted rRNA methylase YqxC, contains S4 and FtsJ domains [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440802 [Multi-domain]  Cd Length: 248  Bit Score: 292.35  E-value: 6.43e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316544   5 MRLDAALVQLGLARSRALARAAIEQGRVSVDGRAIVKPAHPVADGARIVVEGEDH-YVSRAAHKLIAALDAAAIDSSGML 83
Cdd:COG1189     1 ERLDVLLVERGLAESREKAQRLIMAGRVLVNGQVVDKPGTKVPEDAEIEVKGEELpYVSRGGLKLEGALDAFGIDVAGKV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316544  84 CLDLGASTGGFTQVLLERGAARVVALDVGHGQLAPSIALDPRVVSVEGENARALTAERLaavsgiAERPQLVVGDLSFIP 163
Cdd:COG1189    81 CLDIGASTGGFTDCLLQRGAAKVYAVDVGYGQLAWKLRQDPRVVVLERTNARYLTPEDL------PEPPDLVVIDVSFIS 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316544 164 LRLILPAIVATAAPEAPIILLVKPQFEVGRTGV-REGVVRDPALREDAIMGVLWAAYDLGLLAERVDSSPVLGTSGNHEY 242
Cdd:COG1189   155 LTLVLPALLALLKPGGELVALVKPQFEVGRERVgKGGVVRDPALHAEVIEKVLAAAAELGLRVLGLTPSPITGPDGNIEF 234
                         250
                  ....*....|...
gi 2388316544 243 LAVFRPGAGEHPT 255
Cdd:COG1189   235 LLWLRKGGGPDPD 247
tly TIGR00478
TlyA family rRNA methyltransferase/putative hemolysin; Members of this family include TlyA ...
6-241 2.94e-44

TlyA family rRNA methyltransferase/putative hemolysin; Members of this family include TlyA from Mycobacterium tuberculosis, an rRNA methylase whose modifications are necessary to confer sensitivity to ribosome-targeting antibiotics capreomycin and viomycin. Homology supports identification as a methyltransferase. However, a parallel literature persists in calling some members hemolysins. Hemolysins are exotoxins that attack blood cell membranes and cause cell rupture, often by forming a pore in the membrane. A recent study (2013) on SCO1782 from Streptomyces coelicolor shows hemolysin activity as earlier described for a homolog from the spirochete Serpula (Treponema) hyodysenteriae and one from Mycobacterium tuberculosis. [Unknown function, General]


Pssm-ID: 129570 [Multi-domain]  Cd Length: 228  Bit Score: 149.57  E-value: 2.94e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316544   6 RLDAALVQLGLARSRALARAAIEQGRVSVDGRAIVKPAHPVADGARIVVEGEDHYVSRAAHKLIAALDAAAIDSSGMLCL 85
Cdd:TIGR00478   1 RLDILLVRRGLFESREKAKRLILKGFVLVNGKKVDKPSALVDFDAKIELLQNPLFVSRGGEKLKEALEEFNIDVKNKIVL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316544  86 DLGASTGGFTQVLLERGAARVVALDVGHGQLAPSIALDPRVVSVEGENARALTAERLAavsgiaerPQLVVGDLSFIPLR 165
Cdd:TIGR00478  81 DVGSSTGGFTDCALQKGAKEVYGVDVGYNQLAEKLRQDERVKVLERTNIRYVTPADIF--------PDFATFDVSFISLI 152
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2388316544 166 LILPAIVATAAPEApIILLVKPQFEVGRTGVR-EGVVRDPALREDAIMGVLWAAYDLGLLAERVDSSPVLGTSGNHE 241
Cdd:TIGR00478 153 SILPELDLLLNPND-LTLLFKPQFEAGREKKNkKGVVRDKEAIALALHKVIDKGESPDFQEKKIIFSLTKGKRGNVE 228
FtsJ pfam01728
FtsJ-like methyltransferase; This family consists of FtsJ from various bacterial and archaeal ...
60-243 3.23e-35

FtsJ-like methyltransferase; This family consists of FtsJ from various bacterial and archaeal sources FtsJ is a methyltransferase, but actually has no effect on cell division. FtsJ's substrate is the 23S rRNA. The 1.5 A crystal structure of FtsJ in complex with its cofactor S-adenosylmethionine revealed that FtsJ has a methyltransferase fold. This family also includes the N terminus of flaviviral NS5 protein. It has been hypothesized that the N-terminal domain of NS5 is a methyltransferase involved in viral RNA capping.


Pssm-ID: 426399  Cd Length: 179  Bit Score: 124.62  E-value: 3.23e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316544  60 YVSRAAHKLIAALDAAAIDSSGMLCLDLGASTGGFTQVLLERGAARVVALDVGHGQLaPSIALDPRVVSVEGeNARALTA 139
Cdd:pfam01728   1 YRSRAAYKLLEIDEKFGLLKPGKTVLDLGAAPGGWSQVALQRGAGKVVGVDLGPMQL-WKPRNDPGVTFIQG-DIRDPET 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316544 140 ERLaAVSGIAERPQLVVGDLS-FIPLRLILPAIVAtaapeapiILLVKPQFEVGRTGVRE-GVVRDPALREDAIMGVLWA 217
Cdd:pfam01728  79 LDL-LEELLGRKVDLVLSDGSpFISGNKVLDHLRS--------LDLVKAALEVALELLRKgGNFVCKVFQGEDFSELLYL 149
                         170       180
                  ....*....|....*....|....*...
gi 2388316544 218 aydLGLLAERVDS--SPVLGTSGNHEYL 243
Cdd:pfam01728 150 ---LKLGFEKVGVfkPPASRPESSEEYL 174
S4 cd00165
S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, ...
5-67 4.77e-06

S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized functional similarity between these three protein classes.


Pssm-ID: 238095 [Multi-domain]  Cd Length: 70  Bit Score: 43.39  E-value: 4.77e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2388316544   5 MRLDAALVQLGLARSRALARAAIEQGRVSVDGRAIVKPAHPVADGARIVVEGEDHYVSRAAHK 67
Cdd:cd00165     1 MRLDKILARLGLAPSRSEARQLIKHGHVLVNGKVVTKPSYKVKPGDVIEVDGKSIEEDIVYED 63
S4 smart00363
S4 RNA-binding domain;
5-61 8.80e-06

S4 RNA-binding domain;


Pssm-ID: 214638 [Multi-domain]  Cd Length: 60  Bit Score: 42.58  E-value: 8.80e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2388316544    5 MRLDAALVQLGLARSRALARAAIEQGRVSVDGRAIVKPAHPVADGARIVVEGEDHYV 61
Cdd:smart00363   1 RRLDKFLARLGLAPSRSQARRLIEQGRVKVNGKKVTKPSYIVKPGDVISVRGKELKR 57
PRK11760 PRK11760
putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional
79-126 5.51e-03

putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional


Pssm-ID: 236971 [Multi-domain]  Cd Length: 357  Bit Score: 37.89  E-value: 5.51e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2388316544  79 SSGMLCLDLGASTGGFTQVLLERGaARVVALDvgHGQLAPSIALDPRV 126
Cdd:PRK11760  210 APGMRAVDLGAAPGGWTYQLVRRG-MFVTAVD--NGPMAQSLMDTGQV 254
 
Name Accession Description Interval E-value
YqxC COG1189
Predicted rRNA methylase YqxC, contains S4 and FtsJ domains [Translation, ribosomal structure ...
5-255 6.43e-100

Predicted rRNA methylase YqxC, contains S4 and FtsJ domains [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440802 [Multi-domain]  Cd Length: 248  Bit Score: 292.35  E-value: 6.43e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316544   5 MRLDAALVQLGLARSRALARAAIEQGRVSVDGRAIVKPAHPVADGARIVVEGEDH-YVSRAAHKLIAALDAAAIDSSGML 83
Cdd:COG1189     1 ERLDVLLVERGLAESREKAQRLIMAGRVLVNGQVVDKPGTKVPEDAEIEVKGEELpYVSRGGLKLEGALDAFGIDVAGKV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316544  84 CLDLGASTGGFTQVLLERGAARVVALDVGHGQLAPSIALDPRVVSVEGENARALTAERLaavsgiAERPQLVVGDLSFIP 163
Cdd:COG1189    81 CLDIGASTGGFTDCLLQRGAAKVYAVDVGYGQLAWKLRQDPRVVVLERTNARYLTPEDL------PEPPDLVVIDVSFIS 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316544 164 LRLILPAIVATAAPEAPIILLVKPQFEVGRTGV-REGVVRDPALREDAIMGVLWAAYDLGLLAERVDSSPVLGTSGNHEY 242
Cdd:COG1189   155 LTLVLPALLALLKPGGELVALVKPQFEVGRERVgKGGVVRDPALHAEVIEKVLAAAAELGLRVLGLTPSPITGPDGNIEF 234
                         250
                  ....*....|...
gi 2388316544 243 LAVFRPGAGEHPT 255
Cdd:COG1189   235 LLWLRKGGGPDPD 247
tly TIGR00478
TlyA family rRNA methyltransferase/putative hemolysin; Members of this family include TlyA ...
6-241 2.94e-44

TlyA family rRNA methyltransferase/putative hemolysin; Members of this family include TlyA from Mycobacterium tuberculosis, an rRNA methylase whose modifications are necessary to confer sensitivity to ribosome-targeting antibiotics capreomycin and viomycin. Homology supports identification as a methyltransferase. However, a parallel literature persists in calling some members hemolysins. Hemolysins are exotoxins that attack blood cell membranes and cause cell rupture, often by forming a pore in the membrane. A recent study (2013) on SCO1782 from Streptomyces coelicolor shows hemolysin activity as earlier described for a homolog from the spirochete Serpula (Treponema) hyodysenteriae and one from Mycobacterium tuberculosis. [Unknown function, General]


Pssm-ID: 129570 [Multi-domain]  Cd Length: 228  Bit Score: 149.57  E-value: 2.94e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316544   6 RLDAALVQLGLARSRALARAAIEQGRVSVDGRAIVKPAHPVADGARIVVEGEDHYVSRAAHKLIAALDAAAIDSSGMLCL 85
Cdd:TIGR00478   1 RLDILLVRRGLFESREKAKRLILKGFVLVNGKKVDKPSALVDFDAKIELLQNPLFVSRGGEKLKEALEEFNIDVKNKIVL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316544  86 DLGASTGGFTQVLLERGAARVVALDVGHGQLAPSIALDPRVVSVEGENARALTAERLAavsgiaerPQLVVGDLSFIPLR 165
Cdd:TIGR00478  81 DVGSSTGGFTDCALQKGAKEVYGVDVGYNQLAEKLRQDERVKVLERTNIRYVTPADIF--------PDFATFDVSFISLI 152
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2388316544 166 LILPAIVATAAPEApIILLVKPQFEVGRTGVR-EGVVRDPALREDAIMGVLWAAYDLGLLAERVDSSPVLGTSGNHE 241
Cdd:TIGR00478 153 SILPELDLLLNPND-LTLLFKPQFEAGREKKNkKGVVRDKEAIALALHKVIDKGESPDFQEKKIIFSLTKGKRGNVE 228
FtsJ pfam01728
FtsJ-like methyltransferase; This family consists of FtsJ from various bacterial and archaeal ...
60-243 3.23e-35

FtsJ-like methyltransferase; This family consists of FtsJ from various bacterial and archaeal sources FtsJ is a methyltransferase, but actually has no effect on cell division. FtsJ's substrate is the 23S rRNA. The 1.5 A crystal structure of FtsJ in complex with its cofactor S-adenosylmethionine revealed that FtsJ has a methyltransferase fold. This family also includes the N terminus of flaviviral NS5 protein. It has been hypothesized that the N-terminal domain of NS5 is a methyltransferase involved in viral RNA capping.


Pssm-ID: 426399  Cd Length: 179  Bit Score: 124.62  E-value: 3.23e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316544  60 YVSRAAHKLIAALDAAAIDSSGMLCLDLGASTGGFTQVLLERGAARVVALDVGHGQLaPSIALDPRVVSVEGeNARALTA 139
Cdd:pfam01728   1 YRSRAAYKLLEIDEKFGLLKPGKTVLDLGAAPGGWSQVALQRGAGKVVGVDLGPMQL-WKPRNDPGVTFIQG-DIRDPET 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316544 140 ERLaAVSGIAERPQLVVGDLS-FIPLRLILPAIVAtaapeapiILLVKPQFEVGRTGVRE-GVVRDPALREDAIMGVLWA 217
Cdd:pfam01728  79 LDL-LEELLGRKVDLVLSDGSpFISGNKVLDHLRS--------LDLVKAALEVALELLRKgGNFVCKVFQGEDFSELLYL 149
                         170       180
                  ....*....|....*....|....*...
gi 2388316544 218 aydLGLLAERVDS--SPVLGTSGNHEYL 243
Cdd:pfam01728 150 ---LKLGFEKVGVfkPPASRPESSEEYL 174
S4 cd00165
S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, ...
5-67 4.77e-06

S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized functional similarity between these three protein classes.


Pssm-ID: 238095 [Multi-domain]  Cd Length: 70  Bit Score: 43.39  E-value: 4.77e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2388316544   5 MRLDAALVQLGLARSRALARAAIEQGRVSVDGRAIVKPAHPVADGARIVVEGEDHYVSRAAHK 67
Cdd:cd00165     1 MRLDKILARLGLAPSRSEARQLIKHGHVLVNGKVVTKPSYKVKPGDVIEVDGKSIEEDIVYED 63
S4 smart00363
S4 RNA-binding domain;
5-61 8.80e-06

S4 RNA-binding domain;


Pssm-ID: 214638 [Multi-domain]  Cd Length: 60  Bit Score: 42.58  E-value: 8.80e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2388316544    5 MRLDAALVQLGLARSRALARAAIEQGRVSVDGRAIVKPAHPVADGARIVVEGEDHYV 61
Cdd:smart00363   1 RRLDKFLARLGLAPSRSQARRLIEQGRVKVNGKKVTKPSYIVKPGDVISVRGKELKR 57
S4 pfam01479
S4 domain; The S4 domain is a small domain consisting of 60-65 amino acid residues that was ...
5-52 1.08e-03

S4 domain; The S4 domain is a small domain consisting of 60-65 amino acid residues that was detected in the bacterial ribosomal protein S4, eukaryotic ribosomal S9, two families of pseudouridine synthases, a novel family of predicted RNA methylases, a yeast protein containing a pseudouridine synthetase and a deaminase domain, bacterial tyrosyl-tRNA synthetases, and a number of uncharacterized, small proteins that may be involved in translation regulation. The S4 domain probably mediates binding to RNA.


Pssm-ID: 396182 [Multi-domain]  Cd Length: 48  Bit Score: 36.32  E-value: 1.08e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2388316544   5 MRLDAALVQLGLARSRALARAAIEQGRVSVDGRAIVKPAHPVADGARI 52
Cdd:pfam01479   1 RRLDKVLARLGLASSRSQARQLIEHGRVLVNGKVVKDPSYRVKPGDEI 48
RlmE COG0293
23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and ...
58-110 1.84e-03

23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and biogenesis]; 23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 440062 [Multi-domain]  Cd Length: 208  Bit Score: 38.51  E-value: 1.84e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2388316544  58 DHYV---------SRAAHKLIAALDAAAIDSSGMLCLDLGASTGGFTQVLLER--GAARVVALD 110
Cdd:COG0293    19 DPYVkrakkegyrSRAAYKLLEIDEKDKLIKPGMRVVDLGAAPGGWSQVAAKRvgGKGRVIALD 82
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
85-176 2.54e-03

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 36.64  E-value: 2.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2388316544  85 LDLGASTGGFTQVLLERGAARVVALDVGHGQL--APSIALDPRVVSVEGENARALTAERLAavsgiAERPQLVVGDLSFI 162
Cdd:cd02440     3 LDLGCGTGALALALASGPGARVTGVDISPVALelARKAAAALLADNVEVLKGDAEELPPEA-----DESFDVIISDPPLH 77
                          90
                  ....*....|....
gi 2388316544 163 PLRLILPAIVATAA 176
Cdd:cd02440    78 HLVEDLARFLEEAR 91
RsuA COG1187
Pseudouridylate synthase RsuA, specific for 16S rRNA U516 and 23S rRNA U2605 [Translation, ...
27-57 3.22e-03

Pseudouridylate synthase RsuA, specific for 16S rRNA U516 and 23S rRNA U2605 [Translation, ribosomal structure and biogenesis]; Pseudouridylate synthase RsuA, specific for 16S rRNA U516 and 23S rRNA U2605 is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440800 [Multi-domain]  Cd Length: 226  Bit Score: 38.09  E-value: 3.22e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 2388316544  27 IEQGRVSVDGRAIVKPAHPVADGARIVVEGE 57
Cdd:COG1187    24 IEAGRVTVNGKVVTELGTKVDPGDEVTVDGK 54
PRK11760 PRK11760
putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional
79-126 5.51e-03

putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional


Pssm-ID: 236971 [Multi-domain]  Cd Length: 357  Bit Score: 37.89  E-value: 5.51e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2388316544  79 SSGMLCLDLGASTGGFTQVLLERGaARVVALDvgHGQLAPSIALDPRV 126
Cdd:PRK11760  210 APGMRAVDLGAAPGGWTYQLVRRG-MFVTAVD--NGPMAQSLMDTGQV 254
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
85-117 5.81e-03

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 35.23  E-value: 5.81e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2388316544  85 LDLGASTGGFTQVLLERGAARVVALDVGHGQLA 117
Cdd:pfam13649   2 LDLGCGTGRLTLALARRGGARVTGVDLSPEMLE 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH