|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
21-394 |
5.62e-127 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 370.72 E-value: 5.62e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 21 IWALGLVSMLMDISSEMIHALLPVYMVsVLGTSTFAVGIIEGIAEATASITKVFSGALSDWLGRRKFLAALGYGLAAITK 100
Cdd:cd17370 1 VWLLGLVSLFADISYEMARSILPLFLV-VLGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRKPLVILGYGLSALAK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 101 PTFPLASSLDWLIAARFIDRVGKGIRGAPRDALVADIAPPELRGASFGLRQSLDTIGAFLGPLMAIGLMWVTADHFQTVF 180
Cdd:cd17370 80 PLLALAGSWQLVLLLRILERLGKGIRTPPRDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYLLGGNYRTIF 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 181 WIAVLPAFLSVGVLLFLVKEPERPRELRRVRmplHRDELRRLGKSYWWVVAVAAVFTLARFSEAFLILKAQSIGMPIALV 260
Cdd:cd17370 160 LLAAIPALLALLILLFVVKEYPRPPKLRKKS---KKTSLKKLPKAFWLYLLAVALFALGNFSFAFLILRAQELGLSAALI 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 261 PLALVLMSLAYSLSAYPAGILSDKVDRFTILVIGLSLLVCADLVLAFTQSVVGAGLGVVLWGLHMGFTQGLLAKLIADTS 340
Cdd:cd17370 237 PLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLV 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 2416574742 341 PAELRGTAFGMFNLVTGVALLIASVIAGALWDFTGPRGTFLAGAGFAALTIMGL 394
Cdd:cd17370 317 PAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLL 370
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
24-398 |
4.28e-38 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 141.17 E-value: 4.28e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 24 LGLVSMLMDISSEMIHALLPVYMVSvLGTSTFAVGIIEGIAEATASITKVFSGALSDWLGRRKFLAaLGYGLAAITKPTF 103
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAES-LGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLL-LGLLLLAVSTLLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 104 PLASSLDWLIAARFIDRVGKGIRGAPRDALVADIAPPELRGASFGLRQSLDTIGAFLGPLmaIGLMWVTADHFQTVFWIA 183
Cdd:cd17325 79 AFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPL--LGGLLADALGYRAPFLVC 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 184 VLPAFLSVGVLLFLVKEPERPRELRRVRMPLHRDELRRLGKSYW-WVVAVAAVFTLARFS--EAFLILKAQS-IGMPIAL 259
Cdd:cd17325 157 AALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRlLALFLAIFVLAFAFGalEPFLPLYAAElGGLSPAQ 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 260 VPLALVLMSLAYSLSAYPAGILSDKVDRFTILVIGLSLLVCADLVLAFTQSVVGAGLGVVLWGLHMGFTQGLLAKLIADT 339
Cdd:cd17325 237 IGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADI 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 2416574742 340 SPAELRGTAFGMFNLVTGVALLIASVIAGALWDFTGPRGTFLAGAGFAALTIMGLAAVR 398
Cdd:cd17325 317 VPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
21-403 |
9.39e-33 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 128.10 E-value: 9.39e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 21 IWALGLVSMLMDISSEMIHALLPVYMVSVLGTSTFAVGIIEGIAEATASITKVFSGALSD----WLGRRKFLAALGYGLA 96
Cdd:COG2211 12 KLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDrtrtRWGRRRPWILIGAIPL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 97 AI------TKPTFPLASSLDWLIAARFIDRVGKGIRGAPRDALVADIAP-PELRGASFGLRQSLDTIGAFLGPLMAIGLM 169
Cdd:COG2211 92 ALsfvllfTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPdYEERTRLSSWRFAFAGLGGLLASVLPPPLV 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 170 WV----TADHFQTVFWIAVLPAFLSVGVLLFLVKEPERPRElrrVRMPLhRDELRRLG--KSYWWVVAVAAVFTLARFSE 243
Cdd:COG2211 172 AAfggdAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEE---EKVSL-KESLKALLknRPFLLLLLAYLLFFLALALV 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 244 AFLILK--AQSIGMPIALVPLALVLMSLAYSLSAYPAGILSDKVDRFTILVIGLSLLVCADLVLAFTQ--SVVGAGLGVV 319
Cdd:COG2211 248 AALLLYyfKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGpgNLWLLLVLAA 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 320 LWGLHMGFTQGLLAKLIADTSPAEL-------RGTAFGMFNLVTGVALLIASVIAGALWDFTGprgtFLAGAGFAALTIM 392
Cdd:COG2211 328 LAGIGLGAILVLPWAMLADVVDYDEwktgrrrEGLYFGIFTFAIKLGQALAGALAGLLLALFG----YVAGAAQSPSALT 403
|
410
....*....|.
gi 2416574742 393 GLAAVRARLPA 403
Cdd:COG2211 404 GIRLLFFLLPA 414
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
11-359 |
3.93e-31 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 121.62 E-value: 3.93e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 11 PTTNNRIPAGIWALGLVSMLMDISSEMIHALLPvYMVSVLGTSTFAVGIIEGIAEATASITKVFSGALSDWLGRRKFLAa 90
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALP-LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLL- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 91 LGYGLAAITKPTFPLASSLDWLIAARFIDRVGKGIRGAPRDALVADIAPPELRGASFGLRQSLDTIGAFLGPLmaIGLMW 170
Cdd:COG2814 80 LGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPL--LGGLL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 171 VTADHFQTVFWIAVLPAFLSVGVLLFLVKEP---ERPRELRRVRMPLHRDELRRLgksywWVVAVAAVFTLARFSEAFLI 247
Cdd:COG2814 158 ADLFGWRWVFLVNAVLALLALLLLLRLLPESrpaARARLRGSLRELLRRPRLLLL-----LLLAFLLGFGFFALFTYLPL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 248 LKAQSIGMPIALVPLALVLMSLAYSLSAYPAGILSDKVDRFTILVIGLSLLVCADLVLAFTQSVVGAGLGVVLWGLHMGF 327
Cdd:COG2814 233 YLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGL 312
|
330 340 350
....*....|....*....|....*....|..
gi 2416574742 328 TQGLLAKLIADTSPAELRGTAFGMFNLVTGVA 359
Cdd:COG2814 313 LFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
24-391 |
1.04e-29 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 118.08 E-value: 1.04e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 24 LGLVSMLMDISSEMIHALLPVYmVSVLGTSTFAVGIIEGIAEATASITKVFSGALSDWLGRRKFLAaLGYGLAAITKPTF 103
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLY-AHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLL-IGLLIFALATLLY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 104 PLASSLDWLIAARFIDRVGKGIRGAPRDALVADIAPPELRGASFGLRQSLDTIGAFLGPLMAIGLMWVTAdhFQTVFWIA 183
Cdd:cd17489 79 LLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLG--FAVLFIVA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 184 VLPAFLSVgVLLFLVKEPERPRELRRVRMPLHRDELRRLGksywwVVAVAAVFTLARFSE----AFLILKAQSIGmpIAL 259
Cdd:cd17489 157 AVLALLAL-LLVFLVKDPPPVAAEEAEAGTRAFRRLVEKK-----VLPPALILFLASIAYgaisTFLPLYAAERG--ISN 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 260 VPLALVLMSLAYSLSAYPAGILSDKVDRFTILVIGLSLLVCADLVLAFTQSVVGAGLGVVLWGLHMGFTQGLLAKLIADT 339
Cdd:cd17489 229 AGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDL 308
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 2416574742 340 SPAELRGTAFGMFNLVTGVALLIASVIAGALWDFTGPRGTFLAGAGFAALTI 391
Cdd:cd17489 309 VPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLAL 360
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
24-364 |
1.15e-23 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 100.96 E-value: 1.15e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 24 LGLVSMLMDISSEMIHALLPVYMVSVLGTSTFAVGIIEGIAEATASITKVFSGALSDWLGRRKFLAaLGYGLAAITKPTF 103
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLL-IGLLLFALGLLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 104 PLASSLDWLIAARFIDRVGKGIRGAPRDALVADIAPPELRGASFGLRQSLDTIGAFLGPLmaIGLMWVTADHFQTVFWIA 183
Cdd:pfam07690 80 LFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPL--LGGLLASLFGWRAAFLIL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 184 VLPAFLSVGVLLFLVKEPERPRELRRVRMPLHRDELRRL---GKSYWWVVAVAAVFTLARFSEAFLILKAQSIGMPIALV 260
Cdd:pfam07690 158 AILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKAllrDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 261 PLALVLMSLAYSLSAYPAGILSDKVDRFTILVIGLSLLVCADLVLAF---TQSVVGAGLGVVLWGLHMGFTQGLLAKLIA 337
Cdd:pfam07690 238 GLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLlslTLSSLWLLLALLLLGFGFGLVFPALNALVS 317
|
330 340
....*....|....*....|....*..
gi 2416574742 338 DTSPAELRGTAFGMFNLVTGVALLIAS 364
Cdd:pfam07690 318 DLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
21-398 |
6.11e-22 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 96.14 E-value: 6.11e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 21 IWALGLVSMLMDISSEMIHALLPVYMVSVLGTSTFAVGIIEGIAEATASITKVFSGALSDWLGRRKFLAAlGYGLAAITK 100
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLA-GLLLRALGF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 101 PTFPLASSLDWLIAARFIDRVGKGIRGAPRDALVADIAPPELRGASFGLRQSLDTIGAFLGPLMAIglmWVTADHFQTVF 180
Cdd:cd17329 80 ALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGG---LLLLYSFRLLF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 181 WIAVLPAFLSVGVLLFLVKEPERPRELRRVRMPLHRDELRRLGKSYWWVVAVAAVFTLA--RFSEAFLILKAQSIGMPIA 258
Cdd:cd17329 157 LAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIyfQLESTLPVYVVEILGLGES 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 259 LVPLALVLMSLAYSLSAYPAGILSDKVDRFTILVIGLSLLVCADLVLAFTQSVVGAGLGVVLWGLHMGFTQGLLAKLIAD 338
Cdd:cd17329 237 LLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAA 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 339 TSPAELRGTAFGMFNLVTGVALLIASVIAGALWDFTGPRGTFLAGAGFAALTIMGLAAVR 398
Cdd:cd17329 317 LAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGLQ 376
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
21-397 |
3.25e-20 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 91.09 E-value: 3.25e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 21 IWALGLVSMLMDISSEMIHALLPvYMVSVLGTSTFAVGIIEGIAEATASITKVFSGALSDWLGRRKFLAaLGYGLAAITK 100
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILP-AIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLL-PGLLLFGIGG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 101 PTFPLASSLDWLIAARFIDRVGKGIRGAPRDALVADIAPPELRGASFGLRQSLDTIGAFLGPLMAiglMWVTADHFQTVF 180
Cdd:cd17474 79 LLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLG---GLLAAISWRYPF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 181 WIAVLPAFLSVGVLLFLVKEPERPRelRRVRMPLHRDELRRL-GKSYWWVVAVAAVFTLARFSE-AFL-ILKAQSIGMPI 257
Cdd:cd17474 156 FLLAALIPVAFLAILFLLPEPKEKA--KSSSATKLRDLKKALrGRGLLTFLVSAFLYFFLYFAFlTYLpFLLELLYGISP 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 258 ALVPLALVLMSLAYSLSAYPAG-ILSDKVDRFTILVIGLSLLVCADLVLAFTQSVVGAGLGVVLWGLHMGFTQGLLAKLI 336
Cdd:cd17474 234 IIIGLLFAGWSVLLALGSLFVGrLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLV 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2416574742 337 ADTSPAELRGTAFGMFNLVTGVALLIASVIAGALWDFTGPRGTFLAGAGFAALTIMGLAAV 397
Cdd:cd17474 314 TELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
24-394 |
4.48e-19 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 87.87 E-value: 4.48e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 24 LGLVSMLMDISSEMIHALLPVYMVSvLGTSTFAVGIIEGIAEATASITKVFSGALSDWLGRRKFLAaLGYGLAAITKPTF 103
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQS-FGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLL-LGLLLFALGALLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 104 PLASSLDWLIAARFIDRVGKGIRGAPRDALVADIAPPELRGASFGLRQSLDTIGAFLGPLMAIGLMWVTADHFQTVFWIA 183
Cdd:cd06174 79 AFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 184 VLPAFLSVGVLLFLVKEPERPRELRRVRMPLHR--DELRRLGKSYWWVVAVAAVFT----LARFSEAFLILKAQSIGMPI 257
Cdd:cd06174 159 AALALLAAILLLLVVPDPPESARAKNEEASSKSvlKLLKRVLKNPGLWLLLLAIFLvnlaYYSFSTLLPLFLLDLGGLSV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 258 ALVPLALVLMSLAYSLSAYPAGILSDKV-DRFTILVIGLSLLVCADLVLAFTQSVVGAGLGVVLWGLHMGFTQGLLAKLI 336
Cdd:cd06174 239 AVAGLLLSLFGLAGALGSLLLGLLSDRLiGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALI 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 2416574742 337 ADTSPAELRGTAFGMFNLVTGVALLIASVIAGALWD-FTGPRGTFLAGAGFAALTIMGL 394
Cdd:cd06174 319 AELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAaTFGLTGAFLVLAVLLLLAAILL 377
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
21-198 |
1.21e-18 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 86.86 E-value: 1.21e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 21 IWALGLVSMLMDISSEMIHALLPVYMVSVLGTSTFAVGIIEGIAEATASITKVFSGALSDWLGRRKfLAALGYGLAAITK 100
Cdd:cd17325 201 LLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKP-LILIGLLLSAVAL 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 101 PTFPLASSLDWLIAARFIDRVGKGIRGAPRDALVADIAPPELRGASFGLRQSLDTIGAFLGPLmaIGLMWVTADHFQTVF 180
Cdd:cd17325 280 LLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPL--LGGFLYDAFGFATPF 357
|
170
....*....|....*...
gi 2416574742 181 WIAVLPAFLSVGVLLFLV 198
Cdd:cd17325 358 LAAAALLLLAAVLFLLLR 375
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
16-404 |
2.19e-17 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 83.01 E-value: 2.19e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 16 RIPAGIWALGLVSMLMDISSEMIHALLPVYMVSVLGTSTFAVGIIEGIAEATASITKVFSGALSDWLGRRK--FLAALGY 93
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRvlLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 94 GLAAITkptFPLASSLDWLIAARFIDRVGKGIRGAPRDALVADIAPPELRGASFGLRQSLDTIGAFLGPLMAIGLMwvTA 173
Cdd:COG2223 81 GIGLLL---LALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLI--AA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 174 DHFQTVFWIAVLPAFLSVGVLLFLVKEPERPRELRRVRMPLHRDELRRLGKSYW-WVVAVAAVFTLARFSEAFLILKAQS 252
Cdd:COG2223 156 FGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLEALRDPRFWLlSLLYFGTFGSFIGFSSWLPPYLVDQ 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 253 IGMPIALVPLALVLMSLAYSLSAYPAGILSDKVDRFTILVIGLSLLVCADLVLAFTQ-SVVGAGLGVVLWGLHMGFTQGL 331
Cdd:COG2223 236 FGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALgSLWLFLVLFLLLGLALGGGNGA 315
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2416574742 332 LAKLIADTSPAELRGTAFGMFNLVTGVALLIASVIAGALWDFTG-PRGTFLAGAGFAALTIMGLAAVRARLPAQ 404
Cdd:COG2223 316 VFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTLLLYRRPRRA 389
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
21-402 |
8.22e-17 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 81.07 E-value: 8.22e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 21 IWALGLVSMLMDISSEMIHALLPVYMVSVLGTSTFAVGIIEGIAEATASITKVFSGALSDWLGRRKFLA--ALGYGLAAI 98
Cdd:COG2271 11 ILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAigLLLWGLATL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 99 TkptFPLASSLDWLIAARFIDRVGKGIRGAPRDALVADIAPPELRGASFGLRQSLDTIGAFLGPLMAIGLMwvTADHFQT 178
Cdd:COG2271 91 L---FGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLL--AAFGWRA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 179 VFWIAVLPAFLSVGVllflvkeperprelrrvrmplhrdelrrlgkSYWWVVAVAAVFTLARFSEAFLILK--AQSIGMP 256
Cdd:COG2271 166 AFLILGLPGLLLALL-------------------------------RFWLLALAYFLVYFALYGFLTWLPTylVEVRGLS 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 257 IALVPLALVLMSLAYSLSAYPAGILSDKVDRFTILVIGLSLLVCAD--LVLAFTQSVVGAGLGVVLWGLHMGFTQGLLAK 334
Cdd:COG2271 215 LAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALalLLLALLPSPALAIALLFLAGFGLGGAFGLLWA 294
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2416574742 335 LIADTSPAELRGTAFGMFNLVTGVALLIASVIAGALWDFTGPRGTFLAGAGFAALTIMGLAAVRARLP 402
Cdd:COG2271 295 LAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
24-392 |
1.23e-13 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 71.48 E-value: 1.23e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 24 LGLVSMLMDISSEMIHALLPVYmVSVLGTSTFAVGIIEGIAEATASITKVFSGALSDWLGRRKFLAALGYGLAAITKPTF 103
Cdd:cd17490 1 FLIIVFLFWFSQYVYVPFLSPY-AESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFIIIGLLFTVLASLIM 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 104 PLASSLDWLIAARFIDrvgkGIRGA---PRDALVADIAPPELRGASFGLRQSLDTIGAFLGPLMAiGLMwvtADHF--QT 178
Cdd:cd17490 80 ILFPSPWGLLIARFLS----GIAAAtwvSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIG-GLI---AEHFgmRA 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 179 VFWIAVLPAFLSVgVLLFLVKEPERPRELRRVRMPLHRDELRRlgKSYWWVVAVAAVFTLARFSEA--FLILKAQSIGMP 256
Cdd:cd17490 152 PFLLAALAGVLGF-ILSLFIKEERREKKPVLTELKELLSVLKD--KKLLFFSLLAILQQMITFSTTfgFTPLIAKQLGAS 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 257 IALVPLALVLMSLAYSLSAYPAGILSDKV--DRFTILVIGLSLLVCADLV--------LAFTQSVVGAGLGVVLwglhmg 326
Cdd:cd17490 229 SFQLGLLSIIYLLPNALASLLSGTLFYKKlgERNTIIIGFLLLGAYCFLIpfapnltlLYLLQALNGFGTGILF------ 302
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2416574742 327 ftqGLLAKLIADTSPAELRGTAFGMFNLVTGVALLIASVIAGALWDFTGPRGTFLAGAGFAALTIM 392
Cdd:cd17490 303 ---PLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAI 365
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
26-389 |
3.21e-13 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 70.28 E-value: 3.21e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 26 LVSMLMDISSEMIHALLPVYMvSVLGTSTFAVGIIEGIAEATASITKVFSGALSDWLGRRKFLAALGyGLAAITKPTFPL 105
Cdd:cd17477 3 LSVALLGLGSGLLLPLLSLRL-EREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGA-AITAVSVLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 106 ASSLDWLIAARFIDRVGKGIRGAPRDALVADIAPPELRGASFGLRQSLDTIGAFLGPLMaigLMWVTADHFQTVFWIAVL 185
Cdd:cd17477 81 TDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLL---LALVGTAGALPFLIAAVL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 186 PAFLSVGVLLFLVKEPERPRELRRVRMplhrdELRRLGKSYWWVVAVAAVFTLARFSeaFLILKAQSIGMPIALVPLALV 265
Cdd:cd17477 158 LLLALVPLLLTRRAAPEIEEAESISLR-----RLLRIAPLALLGAFVAGFLEGAFYS--LLPLYGLRLGLSVAQAALLLA 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 266 LMSLAYSLSAYPAGILSDKVDRF-TILVIGLSLLVCADLVLAFTQSVVGAGLGVVLWGLHMGFTQGLLAKLIADTSPAEL 344
Cdd:cd17477 231 AFVLGGLLLQWPLGWLADRFDRRrVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDE 310
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 2416574742 345 RGTAFGMFNLVTGVALLIASVIAGALWDFTGPRGTFLAGAGFAAL 389
Cdd:cd17477 311 LVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALL 355
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
37-389 |
4.86e-13 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 69.94 E-value: 4.86e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 37 MIHALLPVYMVSVLGTSTFAVGIIEGIAEATASITKVFSGALSDWLGRRK------FLAALGYGLAAItkptfplASSLD 110
Cdd:cd17472 14 LVLPVLSVYAKSLPGATPTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPvilfglLLFIAGSLLAAY-------ATSIY 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 111 WLIAARFIDrvGKGIRGAPRDALVADIAPPELRGASFGLrqsldtIGAFLGPLMAIGLMW--VTADHF--QTVFWIAVLP 186
Cdd:cd17472 87 GLILGRALQ--GSGAISSVVMALLADLTREENRTKAMAL------IGASIGIAFAISMVLgpLLAAHLgvSGLFLITAIL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 187 AFLSVGVLLFLVKEPERPRELR-----RVRMPLHRDELRRLGKSYWWVVAVA-AVFTLarFSEAFLILKAQSIGMPIALV 260
Cdd:cd17472 159 SLVSLLILLFFVPDPPKIVQISekekkKLKKLLKNKRLLRLDFSIFILHFVLmAFFYI--LPLLLTQLGGGKGQLWKVYL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 261 P---LALVLMSlayslsayPAGILSDKVDR-FTILVIGLSLLVCADLVLAFTQ-SVVGAGLGVVLWGLHMGFTQGLLAKL 335
Cdd:cd17472 237 PailIGFILMV--------PFVIYAEKKGKmKQVFVSSILLIAVGFLLLLFAAtSLWLLIIGLIIFFIGFNLLEALLPSL 308
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 2416574742 336 IADTSPAELRGTAFGMFNLVTGVALLIASVIAGALWDFTGPRGTFLAGAGFAAL 389
Cdd:cd17472 309 VSKIAPKEYRGTAMGIYNTSQFLGSFLGGALGGLLWGLLGYSSVFLTILILALL 362
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
23-389 |
5.66e-13 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 69.51 E-value: 5.66e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 23 ALGLVSMLMDISseMIHALLPVyMVSVLGTSTFAVGIIEGIAEATASITKVFSGALSDWLGRRKFLAaLGYGLAAITKPT 102
Cdd:cd17321 2 LLAVFLAALDVT--IVNVALPT-IARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFL-IGLALFGLASLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 103 FPLASSLDWLIAARFIDRVGKGIRGAPRDALVADIAPPELRGASFGLRQSLDTIGAFLGPLMAIGLmwVTADHFQTVFWI 182
Cdd:cd17321 78 CALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLL--LELFGWRWIFLI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 183 AVLpaflsVGVLLFLvkeperprelrrvrmplhrdelrrLGKSYWWVVAVAAVFTLARFS-EAFLILKAQSI-GMPIALV 260
Cdd:cd17321 156 NVP-----IGLVALL------------------------LARTFSGAVLAAFLLGAALGGlLFLLPLYLQGVlGYSPLQA 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 261 PLALVLMSLAYSLSAYPAGILSDKVDRFTILVIGLSLLVCADLVLAFT---QSVVGAGLGVVLWGLHMGFTQGLLAKLIA 337
Cdd:cd17321 207 GLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLgadSSVWLLLPGLVLLGLGLGLFATPLTNAAL 286
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 2416574742 338 DTSPAELRGTAFGMFNLVTGVALLIASVIAGALwdFTGPRGTFLAGAGFAAL 389
Cdd:cd17321 287 SSVPKEKAGAASGILNTARQLGGALGVALLGAL--LTAGLSANLGDSGVAAL 336
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
21-391 |
7.76e-13 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 69.12 E-value: 7.76e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 21 IWALGLVSMLMDISSEMIHALLPVyMVSVLGTSTFAVGIIEGIAEATASITKVFSGALSDWLGRRKFLAALgYGLAAITK 100
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPD-IARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVL-LLLFILGN 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 101 PTFPLASSLDWLIAARFIDRVGKGIRGAPRDALVADIAPPELRGASFGLRQSLDTIGAFLGPLMA--IGLMWvtadHFQT 178
Cdd:cd17324 79 LLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGglLGQLL----GWRA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 179 VFWIAVLPAFLSVGVLLFLVkepERPRELRRVRMPLHRDELRRLGKSYWWVVAVAAVFTLARFSEAF----LILKAQSIG 254
Cdd:cd17324 155 AFLAIAVLALLAALLLWRLL---PSLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYtylaPFLTDVPGF 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 255 MPiALVPLALVLMSLAYSLSAYPAGILSDKVDRFTILVIGLSLLVCADLVLAFTQSVVGAGLGVVLWGLHMGFTQGLLAK 334
Cdd:cd17324 232 SS-SAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQT 310
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 2416574742 335 LIADTSPaELRGTAFGMFNLVTGVALLIASVIAGALWDFTGPRGTFLAGAGFAALTI 391
Cdd:cd17324 311 RVLRLAP-EARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLAL 366
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
22-398 |
1.48e-12 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 68.37 E-value: 1.48e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 22 WALGLVSMLMDISSEMIHALLPVYMVSVLGTSTFAVGIIEGIAEATASITKVFSGALSDWLGRRKFLAA--LGYGLAAIT 99
Cdd:cd17473 2 ITLLLASTLTVMAGAAIAPALPAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAglLLYGIGGVA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 100 kPTFplASSLDWLIAARFIDRVGKGIRGAPRDALVADIAPPELRGASFGLRQSLDTIGAFLGPLMAIGLmwvTADHFQTV 179
Cdd:cd17473 82 -GLF--LDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGAL---AEIGWRAP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 180 FWIAVLPAFLSVGVLLFLvkePERPRELRRVRMPLHRDELRRLGKSYWWVVAVAAVFTLARFSEAF---LILKAQSIGMP 256
Cdd:cd17473 156 FLVYLLALPVLILVLLFL---PEPARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIqlpFLLQERGGGSA 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 257 iALVPLALVLMSLAYSLSAYPAGILSDKVDRFTILVIGLSLLVCADLVLAFTQSVVGAGLGVVLWGLHMGFTQGLLAKLI 336
Cdd:cd17473 233 -ALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWA 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2416574742 337 ADTSPAELRGTAFGMFNLVTGVALLIASVIAGAL-WDFTGPRGTFLAGAGFAALTIMGLAAVR 398
Cdd:cd17473 312 MSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLvNLTGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
50-390 |
2.48e-12 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 67.64 E-value: 2.48e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 50 LGTSTFAVGIIEGIAEATASITKVFSGALSDWLGRRKFLAA--LGYGLAAITKPTFPLASSLDW--LIAARFIDRVGKGI 125
Cdd:cd06173 29 LTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILadLLRALLAAVLALLALLGSLSLwlLLVLAFLLGIASAF 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 126 RGAPRDALVADIAPPELRGASFGLRQSLDTIGAFLGPLMAIGLmwVTADHFQTVFWIAVLPAFLSVGVLLFLVKEPERPR 205
Cdd:cd06173 109 FGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLL--VALLGPGGAFAINALSFLLSALLLLFIRRPPPAAP 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 206 ELRRvrmPLHRDELRRLGKSYWW-------VVAVAAVFTLARFSEAFLILKAQSI-GMPIALVPLALVLMSLAYSLSAYP 277
Cdd:cd06173 187 GESS---SLLLRDLREGLRYLRRspllrllLLALALFALLGGALTVLLPLLAKEVlGGGAAGYGLLLAAFGVGALLGALL 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 278 AGILSDKVDRFTILVIGLSLLVCADLVLAFTQSVVGAGLGVVLWGLHMGFTQGLLAKLIADTSPAELRGTAFGMFNLVTG 357
Cdd:cd06173 264 LGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNS 343
|
330 340 350
....*....|....*....|....*....|...
gi 2416574742 358 VALLIASVIAGALWDFTGPRGTFLAGAGFAALT 390
Cdd:cd06173 344 GAMPLGALLAGLLADALGLSAVFLLAGALLLLA 376
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
40-400 |
5.99e-12 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 66.71 E-value: 5.99e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 40 ALLPVYMVSVLG-----TSTFAVGIIEGIAEATASITKVFSGALSDWLGRRKFLAALGYGLAAITKPTFPLASSLDWLIA 114
Cdd:COG2270 32 FVFPPYFTSVAAlgdpaAATALWGYALAIAGLLVALLAPVLGAIADRSGRKKPFLAFFTLLGVLATAALFFVAPGGLWLG 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 115 ARF--IDRVGKGIRGAPRDALVADIAPPELRGASFGLRQSLDTIGAFLGPLMAIGLMWV--------TADHFQTVFWIAV 184
Cdd:COG2270 112 LLLfvLANIGFEGSLVFYNAFLPDIATPEEIGRVSGLGWALGYLGGVLLLLINLALFLKpeafglpdAGEAVRISFLLTA 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 185 LPAFLSVGVLLFLVKEPERP-------------RELRRV--RMPLHRDELRRLGKSYWWVVAVAAVFTLArfseafLILK 249
Cdd:COG2270 192 LWWLLFALPLFLFLPERPRPgpapprgavragfRELRRTlrELRRYRDLLRFLLAYFFYRDGVQTVIAFA------GIYA 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 250 AQSIGMPIALVPLALVLMSLAYSLSAYPAGILSDKVDRFTILVIGLSLLVCADLVLAFTQSVVGAGLGVVLWGLHMGFTQ 329
Cdd:COG2270 266 AGVLGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLIGLVMGGIQ 345
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2416574742 330 GLLAKLIADTSPAELRGTAFGMFNLVTGVALLIASVIAGALWDFTG-PRGTFLAGAGFAALTIMGLAAVRAR 400
Cdd:COG2270 346 ALSRSLLARLIPPGREAEFFGLYALSGKAASFLGPLLFGLVTQLTGsQRLGILSLIVFFVIGLVLLLRVKVP 417
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
17-203 |
7.72e-12 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 66.05 E-value: 7.72e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 17 IPAGIWALGLVSMLMDISSEMIHALLPVYMVSVLGTSTFAVGIIEGIAEATASITKVFSGALSDWLGRR-KFLAALGYGL 95
Cdd:COG2271 178 ALLRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrKLVLAIGLLL 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 96 AAITKPTFPLASSLDWLIAARFIDRVGKGIRGAPRDALVADIAPPELRGASFGLRQSLDTIGAFLGPLMaIGLMwVTADH 175
Cdd:COG2271 258 AALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLL-VGYL-LDATG 335
|
170 180
....*....|....*....|....*...
gi 2416574742 176 FQTVFWIAVLPAFLSVGVLLFLVKEPER 203
Cdd:COG2271 336 YQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
250-397 |
1.37e-11 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 65.38 E-value: 1.37e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 250 AQSIGMPIALVPLALVLMSLAYSLSAYPAGILSDKVDRFTILVIGLSLLVCADLVLAFTQSVVGAGLGVVLWGLHMGFTQ 329
Cdd:COG2814 37 AADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALF 116
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2416574742 330 GLLAKLIADTSPAELRGTAFGMFNLVTGVALLIASVIAGALWDFTGPRGTFLAGAGFAALTIMGLAAV 397
Cdd:COG2814 117 PAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRL 184
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
56-391 |
4.09e-11 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 63.75 E-value: 4.09e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 56 AVGIIEGIAEATASITKVFS----GALSDWLGRRKFLAaLGYGLAAITKPTFPLASSLDWLIAARFIDRVGKGIRGAPRd 131
Cdd:cd17330 31 ASGYYVGLLQSSYSLGQFLAsplwGRLSDRYGRKPVLL-LSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSVAQ- 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 132 ALVADIAPPELRGASFGLRQSLDTIGAFLGPlmAIGLMWVTADHFQTVFWIAVLPAFLSVGVLLFLVKEperprelrrvr 211
Cdd:cd17330 109 AYIADITDEEERAKAFGIISAAFGLGFILGP--ALGGFLSTPYGYALPFLVAAALALLNLVLVLFFLPP----------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 212 mplhrdeLRRLGKSYWWVVAVAAVF--TLARFSEAFLILKAQSIGMPIALVPLALVLMSLAYslsaypAGILSDKVDRFT 289
Cdd:cd17330 176 -------LRRLLLVYFLIALAFAGLesVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLL------IPRLAKRLGERK 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 290 ILVIGLSLLVCADLVLAFTQSVVGAGLGVVLWGLHMGFTQGLLAKLIADTSPAELRGTAFGMFNLVTGVALLIASVIAGA 369
Cdd:cd17330 243 LLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGP 322
|
330 340
....*....|....*....|..
gi 2416574742 370 LWDFTGPRGTFLAGAGFAALTI 391
Cdd:cd17330 323 LYSFLGPGVPFLLAAGLLLIAL 344
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
24-391 |
2.45e-10 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 61.42 E-value: 2.45e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 24 LGLVSMLMDISSEMIHALLPvYMVSVLGTSTFAVGIIEGIAEATASITKVFSGALSDWLGRRKFLaALGYGLAAITKPTF 103
Cdd:cd17478 1 LSLGHFLNDFYQGFLPALLP-LLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLL-PLGPLLTGLGLSLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 104 PLASSLDWLIAARFIDRVGKGIRgAPRDALVADIAPPELRGASFGLRQSLDTIGAFLGPLMAIglmWVTADHFQTVFWIA 183
Cdd:cd17478 79 GFAPNYWLLLLLVALAGIGSAAF-HPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAA---ALVALFGGLGLLIL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 184 VLPAFLSVGVLLFLVKEPERPRELRRVRMPLHRDELRRLGKSYWWVVAVAAVFTLARFS-EAFLILKAQSIGMPIALVPL 262
Cdd:cd17478 155 LIIPGLAVALLLLRLRPLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSlTTFLPFYLVQRGYSLVFAGL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 263 ALVLMSLAYSLSAYPAGILSDKVDRFTILVIGLSLLVCADLVLAFTQSVVgAGLGVVLWGLHMGFTQGLLAKLIADTSPa 342
Cdd:cd17478 235 LLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIW-SYILLVLAGFLLFASFPVTVVLAQELLP- 312
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 2416574742 343 ELRGTAFGMFNLVTGVALLIASVIAGALWDFTGPRGTFLAGAGFAALTI 391
Cdd:cd17478 313 GNVGLASGLMMGLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGA 361
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
50-197 |
2.82e-10 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 61.44 E-value: 2.82e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 50 LGTSTFAVGIIEGIAEATASITKVFSGALSDWLGRRK--FLAALGYGLAAITKPtfpLASSLDWLIAARFIDRVGKGIRG 127
Cdd:cd17315 29 FGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKslLIAAVLYVIGALLSA---LAPNVWVLIVGRFLLGLGVGLAS 105
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 128 APRDALVADIAPPELRGASFGLRQSLDTIGAFLGPLMAIGLMWVTADHFQTVFWIAVLPAFLSVGVLLFL 197
Cdd:cd17315 106 VLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSPPGWWRLMFALAAVPALLQLLLMFFL 175
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
228-398 |
2.12e-09 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 58.58 E-value: 2.12e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 228 WVVAVAAVFTLARFSEAFLILKAQSIGMPIALVPLALVLMSLAYSLSAYPAGILSDKVDRFTILVIGLSLLVCADLVLAF 307
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 308 TQSVVGAGLGVVLWGLHMGFTQGLLAKLIADTSPAELRGTAFGMFNLVTGVALLIASVIAGALWDFTGPRGTFLAGAGFA 387
Cdd:pfam07690 82 ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILS 161
|
170
....*....|.
gi 2416574742 388 ALTIMGLAAVR 398
Cdd:pfam07690 162 LLAAVLLLLPR 172
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
220-389 |
4.99e-09 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 57.57 E-value: 4.99e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 220 RRLGKSYWWVVAVAAVFTLA----RFSEAFLILK-AQSIGMPIALVPLALVLMSLAYSLSAYPAGILSDKVDRFTILVIG 294
Cdd:COG2271 2 RAPSRYRWRILALLFLAYFLnyldRSNLSVAAPPlQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 295 LSLLVCADLVLAFTQSVVGAGLGVVLWGLHMGFTQGLLAKLIADTSPAELRGTAFGMFNLVTGVALLIASVIAGALWDFT 374
Cdd:COG2271 82 LLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF 161
|
170
....*....|....*
gi 2416574742 375 GPRGTFLAGAGFAAL 389
Cdd:COG2271 162 GWRAAFLILGLPGLL 176
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
28-389 |
5.21e-09 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 57.66 E-value: 5.21e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 28 SMLMDISSEMIHALLPVYMVSVLGTSTFAVGIIEGIA-EATASITKVFS---GALSDWLGRRKFLAALGYGLAaITKPTF 103
Cdd:cd17391 5 NFFTGIGFSLIAPFLPLYIEQLGVTSGGLVELWSGLAfSSTFLVSAIFSpiwGRLADRYGRKPMLLRASLGMA-IVIGLM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 104 PLASSLDWLIAARFIDRVGKGIRGAPrDALVADIAPPELRGASFGLRQSLDTIGAFLGPLmaIGLMWVTADHFQTVFWIA 183
Cdd:cd17391 84 AFVTNVWQLLILRLLQGVFSGYVPNA-TALIASQTPKEKSGWALGTLSTGVVAGTLIGPL--LGGFLADLFGIRNVFFIT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 184 VLPAFLSVGVLLFLVKEPERPRElRRVRMPLHRDELRRLGKSYWWVVAVA-AVFTLARFS-EAFLILKAQSIGMP---IA 258
Cdd:cd17391 161 GGLLFLAFLLTLFFVKEDFKPVE-KKKMVSTKEVWNSVPNPSLLISLFVTtFIIQLANQSiEPILTLYIRQLMGDasnLA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 259 LVP-LALVLMSLAYSLSAYPAGILSDKVDRFTILVIGLsllvCADLVLAFTQSVVGAGLGVVLWGLHMGFTQGLL----A 333
Cdd:cd17391 240 FISgLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGAL----LASALLYIPQAFVQTPWQLGILRFLLGLATGGLlpaiN 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 2416574742 334 KLIADTSPAELRGTAFGMFNLVTGVALLIASVIAGALWDFTGPRGTFLAGAGFAAL 389
Cdd:cd17391 316 SLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLL 371
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
50-396 |
1.75e-08 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 55.69 E-value: 1.75e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 50 LGTSTFAVGIIEGIAEATASITKVFSGALSDWLGRRKflaALGYGLAAITKPTF--PLASSLDWLIAARFIDRVGKGIRG 127
Cdd:cd17316 31 LGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKK---ALILTLLLFGLATLliGLLPTPILLLVLRFLQGIGIGGEY 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 128 APRDALVADIAPPELRGASFGLRQSLDTIGAFLGPLMAIGLMWVTADHF--QTVFWIAVLPAFLSVGVllflvkepeRPR 205
Cdd:cd17316 108 PGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWgwRILFLIGALPALLALLL---------RRR 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 206 ELRRVRMplhrdelrrlgksywWVVAVAAVFTLARFSEAFLilkAQSIGMPIALVPLALVLMSLAYSLSAYPAGILSDKV 285
Cdd:cd17316 179 TLLLILL---------------WFFISFGYYGLTTFLPTYL---QTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 286 DRFTILVIG--LSLLVCADLVLAFTQSVVGAGLGVVLWGLHMGFTQGLLAKLIADTSPAELRGTAFGMFNLVTGVALLIA 363
Cdd:cd17316 241 GRKKTLVIGliLSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGA 320
|
330 340 350
....*....|....*....|....*....|...
gi 2416574742 364 SVIAGALWDFTGPRGTFLAGAGFAALTIMGLAA 396
Cdd:cd17316 321 PPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
21-197 |
2.24e-08 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 55.27 E-value: 2.24e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 21 IWALGLVSMLMDISSEMIHALLPVYMVSVLGTSTFAVGIIEGIAEATASITKVFSGALSDWL--GRRKFLAALGYGLAAI 98
Cdd:cd17319 181 VWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLlrGARRLVIIIGLLLAAV 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 99 TKPTFPLASSLDWLIAARFIDRVGKGIRGAPRDALVADIAPPELRGASFGLRQSLDTIGAFLGPlMAIGLMWVTADHFQT 178
Cdd:cd17319 261 GLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAP-LLIGYLVDATGSYTA 339
|
170
....*....|....*....
gi 2416574742 179 VFWIAVLPAFLSVGVLLFL 197
Cdd:cd17319 340 AFLFLAAVALLAALLVLLL 358
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
128-395 |
2.80e-08 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 55.33 E-value: 2.80e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 128 APRDALVADIAPPELRGASFGLRQSLDTIGAFLGPLMAIGLMWVTA------DHFQTVFWIAVLPAFLSVGVLLFLVKEP 201
Cdd:cd17313 124 GPVRALLPDLVPPEQRSKANGIINFMGGLGGVLGYLLGAILWDHNWfgfalgGNLKVPFYIGAIILLVCVLVTLFFVKEP 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 202 --------ERPRELRRVRMPLHRDELRRLGKSYWWVVAVAAVFTLARFSEAFLI-------------LKAQSIGMPIALV 260
Cdd:cd17313 204 plspeageHSENPSLGEVLKSLLKLLKIMPRSLLRLLLVIFFWWIAFFPFELFFtdymgeevyhgtsAASSHYGAGVRMG 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 261 PLALVLMSLAYSLSAYPAGILSDKVDRFTILVIGLSLLVCADLVLAFTQSVVGAGLGVVLWGLHMGFTQGLLAKLIADTS 340
Cdd:cd17313 284 AWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATININPYPLVSDYH 363
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 2416574742 341 PAELR--GTAFGMFNLVTGVALLIASVIAGALWDFTGPRGTFLAGAGFAALTIMGLA 395
Cdd:cd17313 364 SESGRgqGTDTGLLNLAISLAQILVSLLAGPIIDVKGYGTVFPVAAVASFLSLVGAL 420
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
59-389 |
3.34e-08 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 54.97 E-value: 3.34e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 59 IIEGIAEATASITKVFSGALSDWLGRRK--FLAALGYGLAAITKPTfplASSLDWLIAARFIDRVGKGIRGAPRDALVAD 136
Cdd:cd17360 39 LIVSSTVAGAAVGAAIGGWLNDRFGRRPciLLADALFTIGAIVMAA---APNKEVLIVGRVLVGLGVGIASMTVPLYIAE 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 137 IAPPELRGASFGLRQSLDTIGAFLGPLMAiGLMWVTADHFQTVFWIAVLPAFLSVGVLLFLVKEPERPRELRRVRmplhr 216
Cdd:cd17360 116 AAPPRIRGRLVTINVLFITGGQFVAYVIN-GAFSYLPGGWRWMLGLAAVPAVLQFIGLLFLPESPRWPSTRRALI----- 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 217 delrrLGKSYWWVVAVAAVFTLARFSEAFLilkaQSIGMPIALVPLAL-VLMSLAYSLSAYPAGILSDKVDRFTILVIGL 295
Cdd:cd17360 190 -----VGCGLQAFQQFSGINTVMYYSATIL----QMAGFKDNQNAIWLsLIVAGTNFIFTIVGMYLIDKFGRRKLLLISL 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 296 SLLVCADLVLAFTQSVVGAGLGVVLWGLHMGFTQGLLAKLIAdtsPAELRGTAFGMFNLVTGVALLIASVIAGALWDFTG 375
Cdd:cd17360 261 FGVIVALVVLAVWLALVGLILYLAFFAPGMGPVPWTVNSEIY---PLWARGTGGGCAAAVNWVFNLLVSQTFLTLTQAIG 337
|
330
....*....|....
gi 2416574742 376 PRGTFLAGAGFAAL 389
Cdd:cd17360 338 PYGTFLLFAGLAVL 351
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
45-402 |
4.18e-08 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 54.88 E-value: 4.18e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 45 YMVSVLGTSTFAVGIIEGIAEATASITKVFSGALSDWLGRRK--FLAALGYGLAAITKPtfpLASSLDWLIAARFIDRVG 122
Cdd:cd17359 26 FLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKtlLISAVLFFISALGSA---FSPNFTIFIIARIIGGLA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 123 KGIRGAPRDALVADIAPPELRGASFGLRQSLDTIGAFLGPLM------AIGLMWVTADHFQTVFWIAVLPAFLsVGVLLF 196
Cdd:cd17359 103 VGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLAYIVnylianAGGADWLGAEGWRWMLGLEAIPAIL-FLLGML 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 197 LVkePERPRELRRVrmplhrdelrrlGKSYWWVVAVAAVF-----TLARFSEAFLILkaQSIGMPIALVPLALVLMSLAY 271
Cdd:cd17359 182 FI--PESPRWLVSK------------GKPILIIGIGLAIFqqfvgINVIFYYGPEIF--QNAGFSENAALLQTIGIGVVN 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 272 SLSAYPAGILSDKVDRFTILVIG-----LSLLVCADLVLAFTQSVVGAGLGVVLWGLHMGFTQGLLAK----LIADTSPA 342
Cdd:cd17359 246 VIFTIIAILLVDKVGRKPLLLIGsigmaISLLLIGTAFYFAPGSQASGIVALVLILLFVAFFAMSWGPvtwvLLSEIFPN 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 343 ELRGTAFGMFNLVTGVALLIASVIAGALWDFTGPRGTFLagaGFAALTIMGLAAVRARLP 402
Cdd:cd17359 326 RIRGLAMGIAVFFLWIANFLVSLTFPILLAAFGLAFTFL---IFAVICVLAFLFVWKFVP 382
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
250-403 |
1.06e-07 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 53.32 E-value: 1.06e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 250 AQSIGMPIALVPLALVLMSLAYSLSAYPAGILSDKVDRFTILVIGLSLLVCADLVLAFTQSVVGAGLGVVLWGLHMGFTQ 329
Cdd:cd17324 26 ARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFW 105
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2416574742 330 GLLAKLIADTSPAELRGTAFGMFNLVTGVALLIASVIAGALWDFTGPRGTFLAgagFAALTIMGLAAVRARLPA 403
Cdd:cd17324 106 AIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLA---IAVLALLAALLLWRLLPS 176
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
45-400 |
1.23e-07 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 53.32 E-value: 1.23e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 45 YMVSVLGTSTFAVGIIEGIAEATASITKVFSGALSDWLGRRKfLAALGYGLAAITKPTFPLASSLDWLIAARFIDRVGKG 124
Cdd:COG0738 33 ALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKR-GLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLG 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 125 IRGAPRDALVADIaPPELRGASFGLRQSLDTIGAFLGPLMAIGLMWVTADHFQTVFWIAVLPAFLSVGVLLFLVKEPERP 204
Cdd:COG0738 112 LLDVAANPYVAAL-GPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSWHLPYLILAVLLLLLALLFLRSKLPEIE 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 205 RElRRVRMPLHRDELRRLGKSYWWVVAVAAVF------TLARFSEAFLIlkaQSIGMPIALVPLALVLMSLAYSLSAYPA 278
Cdd:COG0738 191 EE-EEEAAGSAASLKSLLKNPRLLLGGLAIFLyvgaegAIGDWLPLYLK---DVLGLSEATAALGLSLFWGGMTIGRFLG 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 279 GILSDKVDRFTILVIGLSLLVCADLVLAFTQSVVGAGLGVVLWGLHMGFTQGLLAKLIADTSPAElRGTAFGMFNLVTGV 358
Cdd:COG0738 267 GFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKR-TAAAVSAVLIMGIV 345
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 2416574742 359 ALLIASVIAGALWDFTGPRGTFLA-GAGFAALTIMGLAAVRAR 400
Cdd:COG0738 346 GGAIGPPLIGFLADAFGLRAAFLVpLVCYLLILLLALALKRKR 388
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
20-195 |
2.06e-07 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 52.43 E-value: 2.06e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 20 GIWALGLVSMLMDISSEMIHALLPVYMVSVLGTSTFAVGIIEGIAEATASITKVFSGALSDWLGRRKFLAALGYGLAAIT 99
Cdd:cd06174 204 GLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALG 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 100 KPTFPLASSLDWLIAARFIDRVGKGIRGAPRDALVADIAPPELRGASFGLRQSLDTIGAFLGPLmAIGLMWVTADHFQTV 179
Cdd:cd06174 284 LALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPL-LAGFLLAATFGLTGA 362
|
170
....*....|....*.
gi 2416574742 180 FWIAVLPAFLSVGVLL 195
Cdd:cd06174 363 FLVLAVLLLLAAILLL 378
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
7-307 |
4.88e-07 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 50.97 E-value: 4.88e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 7 TVAGPTTNNRIPAGIWALGLVSMLMDISSEMIHALLPVyMVSVLGTSTFAVGIIEGIAEATASITKVFSGALSDWLGRRK 86
Cdd:COG0477 2 SSTDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPS-IAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 87 FLAaLGYGLAAITKPTFPLASSLDWLIAARFIDRVGKGIRGAPRDALVADIAPPELRGASFGLRQSLDTIGAFLGPLmaI 166
Cdd:COG0477 81 VLL-IGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPL--L 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 167 GLMWVTADHFQTVFWIAVLPAFLSVGVLLFLvkePERPRELRRVRMPLHRDELRRLGKSYWWVVAVAAVFTLARFSEAFL 246
Cdd:COG0477 158 GGLLVAALGWRWIFLINAPLGLLALVLRLRL---PESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLL 234
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2416574742 247 ILKAQSIGMPIALVPLALVLMSLAYSLSAYPAGILSDKVDRFTILVIGLSLLVCADLVLAF 307
Cdd:COG0477 235 AGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
21-395 |
5.09e-07 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 51.42 E-value: 5.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 21 IWALGLVSMLMDISSEMIHALLPvYMVSVLGTSTFAVGIIEGIAEATASITKVFSGALSDWLGRRKFLAAlGYGLAAITK 100
Cdd:cd17320 1 LLLLALLVALGPLAIDMYLPALP-AIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLA-GLLLFILAS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 101 PTFPLASSLDWLIAARFIDRVGKGIRGAPRDALVADIAPPELRGASFGLRQSLDTIGAFLGPLmaIGLMWVTADHFQTVF 180
Cdd:cd17320 79 LLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPL--LGGLLLLFFGWRAIF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 181 WIAVLPAFLSVGVLLFLVKEPERPRELRRVRMPLHRDELRRLGKSYWWVVAVAAVFT----LARFSEAFLILKAQsIGMP 256
Cdd:cd17320 157 VFLALLGLLLLLLVLLFLPETLPEEKRKPLLSSLLRAYKRVLKNRRFLGYALALGLSfaglFAYLAAAPFIYIEQ-LGLS 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 257 IALVPLALVLMSLAYSLSAYPAGILSDKVDRFTILVIGLSLLVCADLVLAFTQSVVGAGL-----GVVLWGLHMGFTQGL 331
Cdd:cd17320 236 PAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLwplvaPLFLIFFGFGLIFPN 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2416574742 332 LAKLIADTSPaELRGTAFGMFNLVTGVALLIASVIAGALWDFT-GPRGTFLAGAGFAALTIMGLA 395
Cdd:cd17320 316 ATSLALEPFP-HVAGTASALLGFLQFLIGALAGALVGLLPNGTaLPMGLLILVLGLLALLLLILL 379
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
244-407 |
5.37e-07 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 51.06 E-value: 5.37e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 244 AFLILKAQSIGMPIALVPLALVLMSLAYSLSAYPAGILSDKVDRFTILVIGLSLLVCADLVLAFTQSVVGAGLGVVLWGL 323
Cdd:cd17489 17 PVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 324 HMGFTQGLLAKLIADTSPAELRGTAFGMFNLVTGVALLIASVIAGALWDFTGPRGTFLAGAGFAALTIMGLAAVRARLPA 403
Cdd:cd17489 97 GWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPV 176
|
....
gi 2416574742 404 QGSI 407
Cdd:cd17489 177 AAEE 180
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
51-390 |
6.31e-07 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 51.20 E-value: 6.31e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 51 GTSTFAVGIIEGIAEATASITKVFSGALSDWLGRRK--FLAALGYGLAAITkptFPLASSLDWLIAARFIDRVGKGIRGA 128
Cdd:cd17362 35 NLSSLQSGLVVSGSLLGALLGSLVAGALIDRLGRRKelILAALLYLVGSLV---TGLAPSYPVLLVGRLIYGVGIGLAMH 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 129 PRDALVADIAPPELRGASFGLRQSLDTIGAFLGPLMAIGLMWVTADhFQTVFWIAVLPAFLSVGVLLFLvkePERPRELR 208
Cdd:cd17362 112 AAPVYIAETSPSHIRGLLVSLKELFIVLGILLGYVSGYAFADVVGG-WRYMYGLAAPPALLLGIGMWFL---PPSPRWQG 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 209 RVRMPLhrdelrrlgksywwVVAVAAVFTLARFSEAFLILKAQSIGMPIALVP-----LALVLMSLAYSLSAYPAGILSD 283
Cdd:cd17362 188 NYRKPL--------------IIGLGLVLFQQITGQPSVLYYAATIFKSAGFSAasdatLVSVGLGVFKLLMTIVAVLLVD 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 284 KVDRFTILVIGLSLLVCADLVLAFTQSVVGAGLGVVLWG------LHMGFTQ---GLLAKLI-ADTSPAELRGTAFGMFN 353
Cdd:cd17362 254 KLGRRPLLLGGVSGMVVSLFLLAAYNLFVQMGPAGLAWLslvallLYVGAYQisfGPISWLMvSEIFPLRVRGRAIALAV 333
|
330 340 350
....*....|....*....|....*....|....*....
gi 2416574742 354 LVTGVALLIASVIAGALWDFTGPRGTFL--AGAGFAALT 390
Cdd:cd17362 334 LVNFGSNALVSLAFLPLQELIGLPGTFLgfGVIGVLALL 372
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
18-164 |
1.03e-06 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 50.34 E-value: 1.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 18 PAGIWALGLVSMLMDISSEMIHALLPVYmVSVLGTST----FAVGIIEGIAEATASITKVFSGALSDWLG-RRKFLAALG 92
Cdd:cd17391 200 PSLLISLFVTTFIIQLANQSIEPILTLY-IRQLMGDAsnlaFISGLVFSATGVSSLLSAPRLGKLGDRIGhHRILLGALL 278
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2416574742 93 YGLAAITKPTFplASSLDWLIAARFIDRVGKGIRGAPRDALVADIAPPELRGASFGLRQSLDTIGAFLGPLM 164
Cdd:cd17391 279 ASALLYIPQAF--VQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLL 348
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
49-211 |
1.29e-06 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 49.99 E-value: 1.29e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 49 VLGTSTFAVGIIEGIaeatasitkvFSGALSDWLGRRKFLAaLGYGLAAITKPTFPLASSLDWLIAARFIDRVGKGIRGA 128
Cdd:cd17371 38 LLGTVTLAGGAIGGI----------LGGILADRFGRVRVLV-ITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 129 PRDALVADIAPPELRGASFGLRQSLDTIGAFLGPLMAIGLMWVTADHF--QTVFWIAVLPAFLSVGVLLFlVKEPERPRE 206
Cdd:cd17371 107 AGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPPEIawRVLFLLGALPALLVLFIRRF-VKEPPQWQA 185
|
....*
gi 2416574742 207 LRRVR 211
Cdd:cd17371 186 ARAAR 190
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
42-391 |
1.48e-06 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 49.93 E-value: 1.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 42 LPVYMVSVLGTSTFAVGIIEGIAEATASITKVFSGALSDWLGRRKFLAaLGYGLAAITKPTFPLASSLDWLIAARFIDRV 121
Cdd:cd17475 18 LAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLA-VGLLLMGAAALLMALVGSYPVLLVLLFLVGA 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 122 GKGIRGAPRDALVADIAPPELRGASFGLRQSLDTIGAFLG----PLMAIGLMWvtadhfQTVFWIAVLPAFLSVGVLLFL 197
Cdd:cd17475 97 GYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAaallPPLALHYGW------RAAFVVAGLVSILAAVLFWLF 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 198 VKEPERPRELRRVRMPLHRDELRRLGKSYWWVVAVAAV------FTLARFSEAFLIlkaQSIGMPIALVPLALVLMSLAY 271
Cdd:cd17475 171 YREPPAASAATESASTLLRSLKEVLRNRDVWLIAIAGAllvapqFALLTFLLLFLH---DHLGLSVVAAGALLAVAQLGG 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 272 SLSAYPAGILSDKVD---RFTILVIGLSLLVCADLVLAFTQSVVGAGLGVVLWGLhMGFT----QGLLAKLIADTSPAEL 344
Cdd:cd17475 248 ALGRIGLGRVSDRVFggrRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLIL-LGLFaigwNGLYLTLVAESAGPEQ 326
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 2416574742 345 RGTAFGMFNLVTGVALLIASVIAGALWDFT-GPRGTFLAGAGFAALTI 391
Cdd:cd17475 327 AGTALGLANTINFIGIAIGPPLFGLLVDAThSYAPAWLALALLLVLAA 374
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
47-208 |
1.49e-06 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 49.96 E-value: 1.49e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 47 VSVLGTSTFAVGIIEGIAEATASITKVFSGALSDWLGRRKFL--AALGYGLAAITKPTFPLASSLDWLIAARFIDRVGKG 124
Cdd:pfam00083 38 VSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLliANVLFVIGAVLQGAAKGKWSVYQLIVGRVLVGIGVG 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 125 IRGAPRDALVADIAPPELRGASFGLRQSLDTIGAFLgplmAIGLMWVTADHFQTVFWIAV--LPAFLSVGVLLFLVKEPE 202
Cdd:pfam00083 118 GASVLAPMYISEIAPKKLRGALGSLYQLAITFGILL----AYIFGLGLNKTSNSDGWRIPlgLQLVPALLLIIGLLFLPE 193
|
....*.
gi 2416574742 203 RPRELR 208
Cdd:pfam00083 194 SPRWLV 199
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
50-404 |
1.58e-06 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 49.87 E-value: 1.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 50 LGTSTFAVGIIEGIAEATASITKVFSGALSDWLGRRKFLAaLGYGLAAITKPTFPLASSLDWLIAARFIDRVGKGIRGAP 129
Cdd:COG2807 48 LGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLL-LALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVL 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 130 RDALVADIAPpELRGASFGLRQSLDTIGAFLGPLMAIglMWVTADHFQTVFWIAVLPAFLSVGVLLFLVKEPERPRELRR 209
Cdd:COG2807 127 LPGLIKRWFP-DRVGLMTGLYTAAMGLGAALAAGLTV--PLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAP 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 210 VRMPLHRDELRRLGksyWWVVAVAAVFTLARFSE-AFLILKAQSIGMPIALVPLALVLMSLAYSLSAYPAGILSDKVDRF 288
Cdd:COG2807 204 AAASLRSLWRSPLA---WLLTLFFGLQSLLYYAVvAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDR 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 289 TILVIGLSLLVCADLVLAFTQSVVGAGLGVVLWGLHMGFTQGLLAKLIADTSP-AELRGTAFGMFNLVTGVALLIASVIA 367
Cdd:COG2807 281 RPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARtPAEAAALSGMAQSVGYLLAALGPLLV 360
|
330 340 350
....*....|....*....|....*....|....*....
gi 2416574742 368 GALWDFTGP-RGTFLAGAGFAAL-TIMGLAAVRARLPAQ 404
Cdd:COG2807 361 GALHDATGSwTAALLLLAALAVLmLVAGLLAGRPYVEDA 399
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
37-398 |
1.92e-06 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 49.53 E-value: 1.92e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 37 MIHALLPVYMVSvLGTSTFAVGIIEGIAEATASITKVFSGALSDWLGRRKFL------AALGYGLAAitkptfpLASSLD 110
Cdd:cd17390 14 MILPLLSTHIRS-LGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLliclllTALGYVLLG-------FSTSLA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 111 WLIAARFIDRVGKGIRGAPRdALVADIAPPELRGASFGLRQSLDTIGAFLGPLMAiGLMWVTADHFQTVFWIAVLPAFLS 190
Cdd:cd17390 86 LLFLSRIPLGIFKHTQSLCK-AYLSDLVSEQERSRVLGRFNAASSLGFILGPVVG-GHLAETDGGFYYVALLCSAIFILN 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 191 VGVLLFLVKEperprelrrvrmplhrdelrrlgksYWWVVAVAAVFTLAR--FSEAFLILKAQSIGMPIALVPLALVLMS 268
Cdd:cd17390 164 AGLVWFLLSK-------------------------LWDLLLVRFLMGFSVllFRSNFSLYLEERFDLSPKTIGYLISYSG 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 269 LAYSLSAYPAGILSD--KVDRFTILVIGLSLLVCADLVLAFTQSVVGAGLGVVLWGLHMGFTQGLLAKLIADTSPAELRG 346
Cdd:cd17390 219 VLGALSGFLVGRILKlyKNNEYLLLLHSFILLALSLLGLALAPSIWLLVLCLTPLSISSAVLRTCSTSLLLSRGKSKERG 298
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 2416574742 347 TAFGMFNLVTGVALLIASVIAGALWDFtGPRGTFLAGAGFAALTIMGLAAVR 398
Cdd:cd17390 299 TLLGVGQSVTSLARILAPLLSGLLQEF-SVSGPGLLGAVLALAAILLMLARQ 349
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
245-375 |
2.38e-06 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 49.09 E-value: 2.38e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 245 FLILKAQSIGMPIALVPLALVLMSLAYSLSAYPAGILSDK--VDRFTILVIGLSLLVCADLVLAFTQSVVGAGLGVVLWG 322
Cdd:cd17352 205 YLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKprIGRLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVLFG 284
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 2416574742 323 LHMGFTQGLLAKLIADTSPAELRGTAFGMFNLVTGVALLIASVIAGALWDFTG 375
Cdd:cd17352 285 FCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTG 337
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
250-397 |
2.43e-06 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 48.65 E-value: 2.43e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 250 AQSIGMPIALVPLALVLMSLAYSLSAYPAGILSDKVDRFTILVIGLSLLVCADLVLAFTQSVVGAGLGVVLWGLHMGFTQ 329
Cdd:COG0477 41 AADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLM 120
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2416574742 330 GLLAKLIADTSPAELRGTAFGMFNLVTGVALLIASVIAGALWDFTGPRGTFLAGAGFAALTIMGLAAV 397
Cdd:COG0477 121 PGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRL 188
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
21-206 |
6.28e-06 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 47.95 E-value: 6.28e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 21 IWALGLVSMLMDISSEMIHALLPVYMVSVLGTSTFAVGIIEGIAEATASITKVFSGALSDWLGRRKFLAALGYGLAAITK 100
Cdd:COG2223 207 FWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLL 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 101 PTFPLASSLDWLIAARFIDRVGKGIRGAPRDALVADIAPPELRGASFGLRQSLDTIGAFLGPLMAiGLMWVTADHFQTVF 180
Cdd:COG2223 287 LLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLF-GALLDATGSYTAAF 365
|
170 180
....*....|....*....|....*.
gi 2416574742 181 WIAVLPAFLSVGVLLFLVKEPERPRE 206
Cdd:COG2223 366 LVFAVLALVALVLTLLLYRRPRRAAA 391
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
68-391 |
6.31e-06 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 47.96 E-value: 6.31e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 68 ASITKVFSGALSDWLGRRK--FLAALGYGLAAITkptFPLASSLDWLIAARFIDRVGKGIRGAPRDALVADIAPPELRGA 145
Cdd:cd17358 54 ALIGALLSGKLADRIGRKRtlLISAIPCILGWLL---IAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGA 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 146 SFGLRQSLDTIGAFLGPLMAIGLMWvtadhfQTVFWIAVLPAFLSVGVLLFLvkePERPRELRRV-RMPLHRDELRRL-G 223
Cdd:cd17358 131 LGSLNQLLVNIGILLGYVLGSFLPW------RTLALIGAIPPVVFLILLFFI---PESPRWLAKKgREEEAEKSLQFLrG 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 224 KSYWWVVAVAAVFTLARFSEAFL------------ILKAQSIGMPIALVP--------------------------LALV 265
Cdd:cd17358 202 KDADISKEAAEIQEELAELEKEAkessfsdlfqrkYLKPLVIGLGLMLFQqlsginavifyassifdeagsgldpnTATI 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 266 LMSLAYSLSAYPAGILSDKVDRFTILVI--GLSLLVCADLVLAFTQSVVGAGLGVVLW-------GLHMGFTQGLLA--- 333
Cdd:cd17358 282 IIGVVQVVGTLVATLLVDRLGRRPLLLVsaIGMGIGLLALGLYFYLQEHGALLSSVSWlplvglvIYIISFSIGLGPlpw 361
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 2416574742 334 KLIADTSPAELRGTAFGMFNLVTGVALLIASVIAGALWDFTGPRGTFLAGAGFAALTI 391
Cdd:cd17358 362 VIMSEIFPAKIKGLAGSLVTLVNWLFAFIVTKTFPFLTLAWGASGTFWIFAGICGLAL 419
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
50-397 |
8.52e-06 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 47.57 E-value: 8.52e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 50 LGTSTFAVGIIEGIAEATASITKVFSGALSDWLGRRKFLAALGYGLAAITKPTfPLASSLDWLIAARFIDRVGKGIRGAP 129
Cdd:cd17319 33 LGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALT-GFATSLTSLYVLRFLLGVAEAGFFPG 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 130 RDALVADIAPPELRGASFGLRQSLDTIGAFLGPLMAIGLMwvTADHFQTVFWIAVLPAFLSVGVLLFLVKeperprelrr 209
Cdd:cd17319 112 AIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLL--LLFGWRWAFIIEGLLGLLLAVLWWFYLR---------- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 210 vrmplhrdelRRLGKSYWWVVAVAAVFTLARFSEAFLIlkaQSIGMPIALVPLALVLMSLAYSLSAYPAGILSDKVDRF- 288
Cdd:cd17319 180 ----------QVWGLALGYFGINYALYGLLTWLPTYLK---QARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGa 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 289 --TILVIGLSLLVCADLVLAFTQSVVGAGLGVVLWGLHMGFTQGLLAKLIADTSPAELRGTAFGMFNLVTGVALLIASVI 366
Cdd:cd17319 247 rrLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLL 326
|
330 340 350
....*....|....*....|....*....|.
gi 2416574742 367 AGALWDFTGprGTFLAGAGFAALTIMGLAAV 397
Cdd:cd17319 327 IGYLVDATG--SYTAAFLFLAAVALLAALLV 355
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
21-195 |
8.68e-06 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 47.21 E-value: 8.68e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 21 IWALGLVSMLMDISSEMIHALLPVYMVSVLGTSTFAVGIIEGIAEATASITKVFSGALSDWLGRRKFLaALGYGLAAITK 100
Cdd:cd17316 179 TLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTL-VIGLILSGILA 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 101 PTFPLA--SSLDWLIAARFIDRVGKGIRGAPRDALVADIAPPELRGASFGLRQSLDTIGAFLGPLmAIGLMWVTADHFQT 178
Cdd:cd17316 258 LPLFYLlsGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPP-LIALLLASTGGTGV 336
|
170
....*....|....*..
gi 2416574742 179 VFWIAVLPAFLSVGVLL 195
Cdd:cd17316 337 PALILALLAIVALIVAL 353
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
73-369 |
8.90e-06 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 47.64 E-value: 8.90e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 73 VFSGALSDWLGRRK--FLAALGYGLAAITKPTFPLASSLDWLIAARFIDRVGKGIRGAPRDALVADIAPPELRGASFGLR 150
Cdd:cd17357 67 FISAFLANRFGRKNglLISNALLVVSSLLMFLSKSAKSPELLIFGRFLVGIACGLSTGFVPMYLQEISPSELRGALGSLT 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 151 QSLDTIGAFLGPLMAIGLMWVTADHFqtvFWIAVLPAFLSVGVLLFLVKEPERPR--------------ELRRVR----- 211
Cdd:cd17357 147 QIGVTLGILLGQVFGLPSVLGTETLW---PYLLFFPGIPALLQLAALPFFPESPKflliskgdeeeaekSLKFLRgiedd 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 212 ----MPLHRDELRRLG-------------KSYWWVVAVAAVFTLAR--------FSEAFLILkaQSIGMPIALVPLALVL 266
Cdd:cd17357 224 vdqeLEEIKKESEQMGdqkqvslmqllrdPSLRLPLLLVLVVSASQqfsginaiFFYSTFIF--ENAGFSPQLAEWANLG 301
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 267 MSLAYSLSAYPAGILSDKVDRFTILVIGLSLLVCADLVLAF------TQSVVGAGLGVVLWGLHMGFTQGL--LAKLI-A 337
Cdd:cd17357 302 IGIVNVLSTIVGPFLIEKVGRRPLLLISLSVCAVALLLMSVflflseQNSWMSYGCIVAIFLFIFFFAIGLgpIPWFIgA 381
|
330 340 350
....*....|....*....|....*....|....*....
gi 2416574742 338 DTSPAELRGTAFGM-------FNLVTGVALLIASVIAGA 369
Cdd:cd17357 382 ELFPQAPRSAAQSLgssvnwtSNFIVGMAFPPLQSIGGG 420
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
37-389 |
1.14e-05 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 46.93 E-value: 1.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 37 MIHALLPVYMVSV---LGTSTFAVGIIEGIAEATASITKVFSGALSDWLGRRKFLaALGYGLAAITKPTFPLASSLDWLI 113
Cdd:cd17333 10 LTDALLGILGPSLeeaFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTL-ILGLLLISLALALIFATPSIYLFV 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 114 AARFIDRVGKGIRGAPRDALVADIApPELRGASFGLRQSLDTIGAFLGPLMAIGLMWVTAdHFQTVFWIAVLPAFLsVGV 193
Cdd:cd17333 89 VLMFLAGLGAGILDTGANTFVGALF-EESSATRLNVLHGFFGLGALIGPLIATSLLTSEL-SWSWAYLIIGLIYLL-LAI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 194 LLFLVKEPERPRELRRVRMPLHRDE--LRRLGKSYWWVVAVAAVFTL---ARFSEAFLILKAQSIGMPIALVPLALVLMS 268
Cdd:cd17333 166 LILLTLFPELPSARNPQQSVGAFSAsaSRLLRNPSIILGALALFLYVgaeTAFSSWVPSYLVEKKHVSDGLAGYLLSGFW 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 269 LAYSLSAYPAGILSDKVDRFTILVIGLSLLVCADLVLAFTQSVVGAGLGVVLWGLHMGFTQGLLAKLIADTSPAElRGTA 348
Cdd:cd17333 246 VGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLPYA-KGKG 324
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 2416574742 349 FGMFNLVTGVALLIASVIAGALWDFTGPRGTFLAGAGFAAL 389
Cdd:cd17333 325 TSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAI 365
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
45-380 |
1.15e-05 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 46.99 E-value: 1.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 45 YMVSVLGTSTFAVGIIEGIAEATASITKVFSGALSDWLGRRKFLAaLGYGLAAITKPTFPLASSLDWLIAARFIDRVGKG 124
Cdd:TIGR00881 20 YLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLP-IGLILCAIVNLFFGFSTSLWVMAALWALNGIFQG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 125 IRGAPRDALVADIAPPELRGASFGLRQSLDTI-GAFLGPLMAIGLMWVTADHfqtvfWIAVLPAFLSVGVLLFLVK---- 199
Cdd:TIGR00881 99 MGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVgGGLLPPLVLFGIAELYSWH-----WVFIVPGIIAIIVSLICFLllrd 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 200 ----------EPERPRELRrVRMPLHRDELRR--------LGKSYWWVVAVAAVF---TLARFSEAFLILKAQSIGMPIA 258
Cdd:TIGR00881 174 spqscglppaEEMPNEEPD-GDAEKKEEELTKkqiflqyvLLNKVLWYISLGYVFvyvVRTGILDWSPLYLTQEKGFSKE 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 259 LVPLALVLMSLAYSLSAYPAGILSDKV---DRFTILVIGLSLLVCAdlVLAFTQSVVGAGLGVVLWGLHMGF----TQGL 331
Cdd:TIGR00881 253 KASWAFTLYELGGLVGTLLAGWLSDKLfngRRGPLAVFFMALIIVS--LLVYWLNPAANPLMDLICLFALGFlvygPQML 330
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 2416574742 332 LAKLIADTSPAELRGTAFGMFNLVTGVALLIASVIAGALWDFTGPRGTF 380
Cdd:TIGR00881 331 IGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFGWAGAF 379
|
|
| MFS_GLUT_Class1 |
cd17431 |
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ... |
29-207 |
1.44e-05 |
|
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340989 [Multi-domain] Cd Length: 445 Bit Score: 46.95 E-value: 1.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 29 MLMDISSEMIHALLPVYMVSvLGTSTFAVGiiegiaeatASITKVFSGALSDWLGRRK------FLAALGYGLAAITKpt 102
Cdd:cd17431 34 TLGDRYGEPISPETLTTLWS-LSVAIFSVG---------GMIGSFSVGLFVNRFGRRNsmlynnLLAFAGAALMGLSK-- 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 103 fpLASSLDWLIAARFIDRVGKGIRGAPRDALVADIAPPELRGASFGLRQSLDTIGAFLGPLMAIGLMWVTADHFQTVFWI 182
Cdd:cd17431 102 --LAKSYEMLILGRFIIGLYCGLTTGLVPMYIGEISPTALRGALGTLHQLGIVVGILISQIFGLEFILGTEELWPLLLGF 179
|
170 180
....*....|....*....|....*
gi 2416574742 183 AVLPAFLSVGVLLFLvkePERPREL 207
Cdd:cd17431 180 TIVPAILQLALLPFC---PESPRYL 201
|
|
| SP |
TIGR00879 |
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ... |
58-207 |
1.57e-05 |
|
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 46.95 E-value: 1.57e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 58 GIIEGIAEATASITKVFSGALSDWLGRRKFL--AALGYGLAAITKPTFPLASSLDWLIAARFIDRVGKGIRGAPRDALVA 135
Cdd:TIGR00879 74 GLVVSIFLVGGFIGALFAGWLSDRFGRKKSLliIALLFVIGAILMGLAAFALSVEMLIVGRVLLGIGVGIASALVPMYLS 153
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2416574742 136 DIAPPELRGASFGLRQSLDTIGAFLGPLMAIG-LMWVTADHFQTVFWIAVLPAFLSVGVLLFLvkePERPREL 207
Cdd:TIGR00879 154 EIAPKALRGALTSLYQLAITFGILVAYGFGSGkVSLNNTLGWRIPLGLQLIPAGLLFLGLFFL---PESPRWL 223
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
133-397 |
2.94e-05 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 45.98 E-value: 2.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 133 LVADIAPPELRGaSFGlrqSLDTIGAFLGPLMAIGLMWVTA-----DHFQTVFW-IAVLPAFLSVGVLLFL---VKEP-- 201
Cdd:cd17369 129 MAVEHAPPKRRG-FYG---SFPQLGAPVGLLLATGVFLLLSallsdEAFLSWGWrIPFLLSAVLVAVGLYIrlrLEETpv 204
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 202 -ERPRELRRVRMPLHRDELRRLGKSYWWVVAVAAVFTLARF-SEAFLILKAQSIGMPIALVPLALVLMSLAYSLSAYP-A 278
Cdd:cd17369 205 fRRAKEAGQVVRAPLVEVLRRHWRALLLAIGLRLAENVLFYlFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPlF 284
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 279 GILSDKVDRFTILVIGLSLLVcadlVLAF--------TQSVVGAGLGVVLWGLHMGFTQGLLAKLIADTSPAELRGTAFG 350
Cdd:cd17369 285 GWLSDRVGRRPVYLAGALLAA----LFAFpffwlldtGSTWLIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRVRYTGAS 360
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 2416574742 351 M-FNLVTGVALLIASVIAGALWDFTGprGTFLAGAGFAALTIMGLAAV 397
Cdd:cd17369 361 LgYQLGAILGGGFAPLIATALVAATG--SWWPVALYLAALAVISLVAA 406
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
45-398 |
3.04e-05 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 45.70 E-value: 3.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 45 YMVSVLGTSTFAVGIIEGIAEATASITKVFSGALSDWLGRRKFLAaLGYGLAAITK---PTFPLASSLDWLIAA-RFIDR 120
Cdd:cd17345 28 YLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLA-IGLILSAIINiliGFVPSATSSVGLMFIlLFLNG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 121 VGKGIRGAPRDALVADIAPPELRGASFGLRQSLDTIGAFL-GPLMAIGLMWVTADHFQTVFWI-AVLPAFLSVGVLLFLV 198
Cdd:cd17345 107 WFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLvGPLAGLGLAIFGDGWWRGAFIFpAIIAIIVAVIVLFLGK 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 199 KEPERP-----RELRRVRMPLHRDELRRLGKSYW-------------WVVAVAAVFT-LARF-----SEAFLIlkaQSIG 254
Cdd:cd17345 187 DTPESEglppiEEYKGDYPEEADGEEEEQELSAWeifvkyvlknkllWYIAIANVFVyLVRYgildwAPTYLS---EVKG 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 255 MPIALVPLALVLMSLAYSLSAYPAGILSDKVD---RFTILVIGLSLLVCADLVLAFTQSV-----VGAGLGVVLWGLHMg 326
Cdd:cd17345 264 FSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLFkgrRAPTGIIFMILVIVALIVYWLAPNVlvdliALIALGFLIYGPVM- 342
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2416574742 327 ftqgLLAKLIADTSPAELRGTAFGM---FNLVTGVALliASVIAGALWDFTGPRGTFLAGAGFAALTIMGLAAVR 398
Cdd:cd17345 343 ----LIGLQALELVPKKAAGTAAGLtglFGYLGGSVL--ATALIGIIVDHFGWNGGFIVLLASCILAIIFLALVA 411
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
20-158 |
3.13e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 45.74 E-value: 3.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 20 GIWALGLVSMLMDISSEMIHALLPVYMVSVLGTSTFAVGIIEGIAEATASITKVFSGALSDWLGRRKFLAAlGYGLAAIT 99
Cdd:COG2814 208 RLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLI-GLLLLALG 286
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 2416574742 100 KPTFPLASSLDWLIAARFIDRVGKGIRGAPRDALVADIAPPELRGASFGLRQSLDTIGA 158
Cdd:COG2814 287 LLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
76-375 |
3.22e-05 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 45.83 E-value: 3.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 76 GALSDWLGRRK------FLAALGYGLAAITkPTFPLASSLDWLIA--ARFIDRVGKGIRGAPRDALVADIAPPELRGASF 147
Cdd:cd17368 61 GAYADRIGRKPamtltlAIMALGTLLIALA-PTYATIGIAAPLLVllARLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYT 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 148 GLRQSLDTIGAFLGPLMAIGL-MWVTADHFQTVFW-IAVLPAFLSVGVLLFLVKEPERPRELRRVRMPLHRDELRRLGKS 225
Cdd:cd17368 140 SWQSASQQVAIVAGALVGYLLsLTLTAEALAEWGWrIPFFIGLLIIPLGLWLRRSLEETEAFLERKARPTRRELFALLAN 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 226 YWWVVAVAAVFTLARFSEAFLIL------KAQSIGMPIALVPLALVLMSLAYSLSAYPAGILSDKVDRF-TILVIGLSLL 298
Cdd:cd17368 220 NRRIILLGMLLVAGSTVTFYFTTvytptyAKTVLGLSARDSFLVTLLAGVANFIWAPLGGALSDRIGRRpVLLVITLAAL 299
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 299 VCADLVLAFTQSVVGAG--LGVVLW-GLHMGFTQGLLAKLIADTSPAELRGTAFGM-FNLVTGVALLIASVIAGALWDFT 374
Cdd:cd17368 300 VTLYPVFAWLTAAPSFGrlLLVLLVlSFFFGMYGGAMVVALVELFPVRVRSTGFSLvYALAVAIFGGFAQFIVTWLIELT 379
|
.
gi 2416574742 375 G 375
Cdd:cd17368 380 G 380
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
227-403 |
4.79e-05 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 45.34 E-value: 4.79e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 227 WWVVAVAAVFTLARFS-----EAFLILKAQSIGMPIALVPLALVLMSLAYSLSAYPAGILSDKVDRFTILVIGLSLLVCA 301
Cdd:cd17355 2 WVVLAVTFLILILSWGiryyfGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 302 DLVLAFTQSVVGAglgVVLWGLHMGFTQGLLAKLIADTS----PAELRGTAFGMFNLVTGVALLIASVIAGALWDFTGPR 377
Cdd:cd17355 82 LVLLALATSLWQL---YLLWGLLGGGGAGTLAAVAFATVaawwFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWR 158
|
170 180
....*....|....*....|....*.
gi 2416574742 378 GTFLAGAGFAALTIMGLAAVRARLPA 403
Cdd:cd17355 159 TALLVLALLALLVLVPVLLLLRRRPA 184
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
268-396 |
6.54e-05 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 44.92 E-value: 6.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 268 SLAYSLSAYPAGILSDKVDRFTILVIGLSLLVCADLVLAFTQSVVGAGLGVVLWGLHMGfTQGLLAKLIADTSPAELRGT 347
Cdd:cd06179 42 SLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGIGAG-TQGLGAAVASELVPNKYRGL 120
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 2416574742 348 AFGMFNLVTGVALLIASVIAGALW--DFTGPRGTFLAGAGFAALTIMGLAA 396
Cdd:cd06179 121 VQGVVNLVASPGSALGPLIAGALVeaNAAGWRWIFYINAIFNALALILLFF 171
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
244-402 |
6.64e-05 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 44.72 E-value: 6.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 244 AFLILKAQSIGMPIALVPLALVLMSLAYSLSAYPAGILSDKVDRFTILVIGLSLLVCADLVLAFTQSVVGAGLGVVLWGL 323
Cdd:cd06174 17 PLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGL 96
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2416574742 324 HMGFTQGLLAKLIADTSPAELRGTAFGMFNLVTGVALLIASVIAGALWDFTGPrGTFLAGAGFAALTIMGLAAVRARLP 402
Cdd:cd06174 97 GSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGF-GWRAVFLIAAALALLAAILLLLVVP 174
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
258-391 |
7.19e-05 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 44.51 E-value: 7.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 258 ALVPLALVLMSLAYSLSAYPAGILSDKVDRFTILVIGLSLLVCADLVLAFTQSVVGAGLGVVLWGlhMGFTQGLLAKLIA 337
Cdd:cd17472 32 TLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQG--SGAISSVVMALLA 109
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 2416574742 338 DTSPAELRGTAFGMFNLVTGVALLIASVIAGALWDFTGPRGTFLAGAGFAALTI 391
Cdd:cd17472 110 DLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSL 163
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
279-390 |
8.91e-05 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 44.16 E-value: 8.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 279 GILSDKVDRFTILVIGLSLLVCADLVLAFTQSVVGAGLGVVLWGLhMGFTQGLLAKLIADTSPAELRGTAFGMFNLVTGV 358
Cdd:cd17388 59 GALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAGI-TGATGAVAAAYIADVTPPEQRARNFGLLGAAFGL 137
|
90 100 110
....*....|....*....|....*....|..
gi 2416574742 359 ALLIASVIAGALWDFtGPRGTFLAGAGFAALT 390
Cdd:cd17388 138 GFIAGPALGGLLGEI-SPRAPFLVAAGLNGLN 168
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
76-401 |
1.36e-04 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 43.78 E-value: 1.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 76 GALSDWLGRRKFLAALGYGlAAITKPTFPLASSLDWLIAARFIDRVgKGIRGAPRDALVADIAPPELRGASFGLRQSLDT 155
Cdd:cd17388 59 GALSDRFGRRPVLLLSLAG-AALDYLLMAFAPTLWWLYLGRIIAGI-TGATGAVAAAYIADVTPPEQRARNFGLLGAAFG 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 156 IGAFLGPLMAiGLMWVTADHfqTVFWIAVLPAFLSVGVLLFLVKE---PERPRELRRVRM-PLHRDELRRLGKSYWWVVA 231
Cdd:cd17388 137 LGFIAGPALG-GLLGEISPR--APFLVAAGLNGLNFLLGLFVLPEslpPERRRAFRWRRAnPFGSLRWLTGFPGLLGLLA 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 232 VAAVFTLAR---------FSEAFLILKAQSIGMPIALVPLALVLmslaysLSAYPAGILSDKVDRFTILVIGLSLLVCAD 302
Cdd:cd17388 214 VFFLIQLIGqvpattwvlFTEDRFDWSPTMVGLSLAVFGLLHAL------FQAFVTGPIAKRLGEKRAILLGLAADALGF 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 303 LVLAFTQSVVGAGLGVVLW---GLHMGFTQGLLAKLIADTSPAELRGTAFGMFNLVTGVALLIASVIAGALwDFTGPRGT 379
Cdd:cd17388 288 LLLAFATQGWMVFPILILLalgGIAGPALQGLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGIFAAS-PATWPGLA 366
|
330 340
....*....|....*....|..
gi 2416574742 380 FLAGagfAALTIMGLAAVRARL 401
Cdd:cd17388 367 WIIG---AALYLICLVLAYRFF 385
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
21-196 |
2.28e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 42.95 E-value: 2.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 21 IWALGLVSMLMDISSEMIHALLPVYMVSVLGTSTFAVGIIEGIAEATASITKVFSGALSDWLGRRKFLAALGYGLAAITK 100
Cdd:cd17330 176 LRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGL 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 101 PTFPLASSLDWLIAARFIDRVGKGIRGAPRDALVADIAPPELRGASFGLRQSLDTIGAFLGPLMAIGLMWVTAdhFQTVF 180
Cdd:cd17330 256 LLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLG--PGVPF 333
|
170
....*....|....*.
gi 2416574742 181 WIAVLPAFLSVGVLLF 196
Cdd:cd17330 334 LLAAGLLLIALFLLSL 349
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
21-308 |
2.60e-04 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 42.76 E-value: 2.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 21 IWALGLVSMLMDISSEMIHALLPVyMVSVLGTSTFAVGIIEGIAEATASITKVFSGALSDWLGRRKFLaALGYGLAAITK 100
Cdd:TIGR00710 7 ALLLGCLSILGPLGIDMYLPAFPE-IAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVL-LLGLFIFALSS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 101 PTFPLASSLDWLIAARFIDRVGKGIRGAPRDALVADIAPPELRGASFGLRQSLDTIGAFLGPLM-AIGLMWVtadHFQTV 179
Cdd:TIGR00710 85 LGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLgGYILVWL---SWHAI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 180 FWIAVLPAFLSVGVLLFLVKEPERPRELRRVRMPLHRDELRRLGKSYW-WVVAVAAVF--TLARFSEAFLILKAQsIGMP 256
Cdd:TIGR00710 162 FAFLSLAGILLSALIFFILPETLPYEARIQISTYFETFLLLLKSKMFWgYALIYGASFggFFAFFSGAPFVYIDI-MGVS 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 2416574742 257 IALVPLALVLMSLAYSLSAYPAGILSDKVDRFTILVIGLSLLVCADLVLAFT 308
Cdd:TIGR00710 241 PSVFGLLFALNIIAMIFGGFLNGRFIKKWGAKSLLRMGLILFAVSAVLLEIT 292
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
244-395 |
2.78e-04 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 43.37 E-value: 2.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 244 AFLILKAQSIGMPIALVPLALVLMSLAYSLSAYPAGILSDKVDRFTILV------IGLSLLVCADLVLAFTQsvvGAGLG 317
Cdd:PRK08633 33 QNTLIKAYDGSEQVILTAIVNALFLLPFLLLSSPAGFLADKFSKNRVIRivklfeVGLTLLIVLAYYLGWFW---LAFAV 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 318 VVLWGLHMGF----TQGLLAKLIadtsPAELRGTAFGMFNLVTGVALLIASVIAGALWDFTGPRGTFLAGAGFAALTIMG 393
Cdd:PRK08633 110 TFLLGAQSAIyspaKYGIIPELV----GKENLSRANGLLEAFTIVAILAGTALFSFLFESVNGNTPSEILGRIAPAGLVL 185
|
..
gi 2416574742 394 LA 395
Cdd:PRK08633 186 LA 187
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
23-375 |
3.06e-04 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 42.59 E-value: 3.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 23 ALGLVSMLMDISSEMIHALLPVYMVSVLGTSTFAVGIIEGIAEATASITKVFSGALSD-----WLGRRKFL--AALGYGL 95
Cdd:cd17332 3 GYGLGDFGNNLIFQIVSTYLLFFYTDVLGLSAAAAGTIFLVARIIDAINDPLMGYLIDrtrsrWGRFRPWLlwGAIPLAL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 96 AAI---TKPTFPLASSLDWLIAARFIDRVGKGIRGAPRDALVADIAP-PELRGASFGLRQSLDTIGAFLGPLMAIGLM-W 170
Cdd:cd17332 83 LFVllfTTPDGSGTGKLIYALITYILLDLLYTLVNIPYTALIPELTDdPEERTSLTSWRMFFATIGGLLVTVLPPPLVaY 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 171 VTADHFQTVFWIAVLPAFLSVGVLLFL----VKEPERPRELRRVRMPLHRDELRRLGKSYWWVVAVAAVFTL----ARFS 242
Cdd:cd17332 163 FGGGNASRGYFLTALIIGIIGIILLLIcffgTRERVVPPEEEKSKLPLLKSLKALLKNRPFLILLLAYLLYFlafnIVNT 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 243 EAFLILKAQSIGMPiALVPLALVLMSLAySLSAYPAGILSDKVDRFTILVIGLSLLVCADLVLAFTQ--SVVGAGLGVVL 320
Cdd:cd17332 243 VLVYYFKYVLGGRA-ELVLLLLLILSGA-LLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFLPpgNLVLILVLAVL 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2416574742 321 WGLHMGFTQGLLAKLIADTS-PAELR------GTAFGMFNLVTGVALLIASVIAGALWDFTG 375
Cdd:cd17332 321 AGIGYGGANLLPWAMLADVIdYGELKtgkrreGIFYSVMTFFRKLGLALAGALVGLILSLAG 382
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
50-400 |
3.13e-04 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 42.57 E-value: 3.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 50 LGTSTFAVGIIEGIAEATASITKVFSGALSDWLGRRKFL--AALGYGLAAITKptfPLASSLDWLIAARFIDRVGKGIRG 127
Cdd:cd17365 29 WGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLlvSVALFGLFTLLT---AFAQSVLQLALLRFLTGLGLGAAM 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 128 APRDALVADIAPPELRGASFGLRQSLDTIGAFLGPLMAIGLMwvtaDHF--QTVFWIAVLPAFLSvgvllflvkeperpr 205
Cdd:cd17365 106 PNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALI----PAFgwRSVFLLGGVPPLIL--------------- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 206 elrrvrMPLhrdelrrLGKSYWWVVAVAAVFTLARFSEAFLILKAQSIGMPIALVPLALVLMSLAYSLSAYPAGILSDKV 285
Cdd:cd17365 167 ------LPL-------LRGTLLLWVTFFMGLLLVYLLNSWLPKLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRF 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 286 DRFTILVIGLSL-LVCADLVLAFTQSVVGAGLGVVLWGLHMGFTQGLLAKLIADTSPAELRGTAFGMFNLVTGVALLIAS 364
Cdd:cd17365 234 GPKRVLALFFALgAVSLALLGVSPASLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGP 313
|
330 340 350
....*....|....*....|....*....|....*..
gi 2416574742 365 VIAGALWDFT-GPRGTFLAGAGFAALTIMGLAAVRAR 400
Cdd:cd17365 314 LLGGLLLAAGlGPESVFLALAIPAALGALAVLLLRLR 350
|
|
| PRK11646 |
PRK11646 |
multidrug efflux MFS transporter MdtH; |
20-182 |
3.73e-04 |
|
multidrug efflux MFS transporter MdtH;
Pssm-ID: 183255 Cd Length: 400 Bit Score: 42.35 E-value: 3.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 20 GIWALGLVSMLMDISSEMIHALLPVYMVSVLGTSTFAVGIIEGIAEATASITKVFSGALSDWLGRRK------FLAALGY 93
Cdd:PRK11646 11 GKYFLLIDNMLVVLGFFVVFPLISIRFVDQLGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPmivtgmLMRAAGF 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 94 GLAAItkptfplASSLDWLIAARFIDRVGKGIRGAPRDALVADIAPPELRGASFGLRQSLDTIGAFLGPLMAiglMWVTA 173
Cdd:PRK11646 91 ATMAI-------AHEPWLLWLSCILSGLGGTLFDPPRTALVIKLIRPHQRGRFFSLLMMQDSAGAVIGALLG---SWLLQ 160
|
....*....
gi 2416574742 174 DHFQTVFWI 182
Cdd:PRK11646 161 YDFRLVCAT 169
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
58-209 |
6.41e-04 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 41.47 E-value: 6.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 58 GIIEGIAEATASITKVFSGALSDWLGRRK--FLAALGYGLAAItkptFPLAS--SLDWLIAARFIDRVGKGIRGAPRDAL 133
Cdd:cd17356 48 GLIVSIVNLGSFFGALISSFLSDRIGRKKsiQIGCVIYIIGAI----IQVAAigKWYQLIVGRIIAGLGVGFASVLVPVY 123
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2416574742 134 VADIAPPELRGASFGLRQSLDTIGAFLGPLMAIGL-MWVTADHFQTVFWIAVLPAFLsvgVLLFLVKEPERPRELRR 209
Cdd:cd17356 124 QSEVAPKHIRGTLVSLYQLAITIGILVAYCINYGThKLDGSAQWRIPLGLQIVWGLL---LLIGMFFLPESPRWLYR 197
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
76-398 |
7.59e-04 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 41.49 E-value: 7.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 76 GALSDWLGRRKFLAALGYGLaAITKPTFPLASSLDWLIAARFIDRVGKGIRGAPRdALVADIAPPELRGASFGLRQSLDT 155
Cdd:cd17389 85 GAASDVYGRKPVLLLTMIGL-AISYALWAVSRSFTIFLLSRIVGGISKGNVSLST-AIVADVTSPKKRSKGMALIGVAFS 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 156 IGAFLGPLMAIGLMWVTADHFQTVFWIAVLPA-FLSVGVLLFLV-KEPErprelrrvrmPLHRDeLRRLGKSYWWVVava 233
Cdd:cd17389 163 LGFIIGPMIGAYFASFTRSLGEVFFSMPALFAlVLALADLLFIFfFLPE----------TLPSN-LRRLGLVYFLYL--- 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 234 AVFTLARFSEAFLILKAQSI-----GMPIALVPLALVLMSLAYSLSAYPAGILSdkvdrftILVIGLSLLVCADLVLAFT 308
Cdd:cd17389 229 FLFSGLEFTLTFLTHQRFQYtsmqqGKMFFFIGIIMALVQGGYVRRIKPGKEKK-------AVLQGLILLIPAFLLIGWA 301
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 309 QSVVGAGLGVVLWGLHMGFTQGLLAKLIADTSPAELRGTAFGMFNLVTGVALLIASVIAGALWDFTGPRGTFLAGAGFAA 388
Cdd:cd17389 302 SSVTVLYAGLFLYSFAAATVVPCLTTLVSGYGSDDQKGTVMGIFRSLGALARALGPIVACTVYWLAGSEACYTIGALLFL 381
|
330
....*....|
gi 2416574742 389 LTIMGLAAVR 398
Cdd:cd17389 382 LPLLLLARLK 391
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
37-385 |
1.22e-03 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 40.67 E-value: 1.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 37 MIHALLPVYM--VSVLGTSTFAV--GIIEGIAEATASITKVFSGALSDWLGRRKFLAALGYGLAAITKPTFPLASSLDWL 112
Cdd:PRK09874 32 LVMPFLPLYVeqLGVTGHSALNMwsGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 113 IAARFIDRVGKGIRGAprDALVADIAPPELRGASFGLRQSLDTIGAFLGPLmAIGLMwvtADHF--QTVFWIAVLPAFLS 190
Cdd:PRK09874 112 ILRALLGLLGGFVPNA--NALIATQVPRNKSGWALGTLSTGGVSGALLGPL-AGGLL---ADSYglRPVFFITASVLFLC 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 191 VGVLLFLVKE---PERPRELRRVRMPLHRDELRRLGKSYWWVV--------AVAAVFTLARFSEAFLILKAQSIGMPIAL 259
Cdd:PRK09874 186 FLVTLFCIREnfqPVSKKEMLHMREVVTSLKNPKLVLSLFVTTliiqvatgSIAPILTLYVRELAGNVSNIAFISGMIAS 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 260 VPlalvlmSLAYSLSAYPAGILSDKVDRFTILVIGLSLLVCADLVLAFTQSVVGAGLGVVLWGLHMGFTQGLLAKLIADT 339
Cdd:PRK09874 266 VP------GVAALLSAPRLGKLGDRIGPEKILITALIFSVLLLIPMSFVQTPLQLGILRFLLGAADGALLPAVQTLLVYN 339
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 2416574742 340 SPAELRGTAFGMFNLVTGVALLIASVIAGALWDFTGPRGTFLAGAG 385
Cdd:PRK09874 340 SSNQIAGRIFSYNQSFRDIGNVTGPLMGAAISANYGFRAVFLVTAG 385
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
73-370 |
1.51e-03 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 40.42 E-value: 1.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 73 VFSGALSDWLGRRKFLAALGYGLAAITKPTfPLASSLDWLIAARFIDRVGKGIRGAPRDALVADIAPPELRGASFGLRQS 152
Cdd:TIGR00895 70 LFFGPLADRIGRRRVLLWSILLFSVFTLLC-ALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFC 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 153 LDTIGAFLGPLMAiglMWVTADH-FQTVFWIA-VLPAFLSVgVLLFLVKEPERPRELRRVRMPLHRDELRRLGKSYW--- 227
Cdd:TIGR00895 149 GYPIGAAVGGFLA---GWLIPVFgWRSLFYVGgIAPLLLLL-LLMRFLPESIDFLVSKRPETVRRIVNAIAPQMQAEaqs 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 228 -----------WVVAVAAVFTLARFSEAFLILKAQSI-------------------GMPIALVPLALVLMSLAYSLSAYP 277
Cdd:TIGR00895 225 alpeqkstqgtKRSVFKALFQGKTARITVLLWLLYFMllvgvyfltnwlpklmvelGFSLSLAATGGALFNFGGVIGSII 304
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 278 AGILSDKVDRFTILVIGLSLLVCADLVLAFTQSVVGAGLGVVLWGLHMGFTQGLLAKLIADTSPAELRGTAFG-MFNLVT 356
Cdd:TIGR00895 305 FGWLADRLGPRVTALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGwAIGIGR 384
|
330
....*....|....
gi 2416574742 357 GVAlLIASVIAGAL 370
Cdd:TIGR00895 385 LGA-IIGPILAGYL 397
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
85-358 |
1.65e-03 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 40.30 E-value: 1.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 85 RKFLAALGYGLAAITKPTFPLASSLDWLIAARFIDRVGKGIRGAPRDALVADIAPPELRGASFGLRQSLDTIGAFLGPLM 164
Cdd:cd17328 63 RKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVV 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 165 AiGLMWVTADHFQTVFWIAVLPAFLSVGVLLFLVKEPERPRELRRVRMPLHR----DELRRLGK--SYWWVVA--VAAVF 236
Cdd:cd17328 143 G-GLVAQATGGWRWAFRVTGVLGVLLAILLLLFVREPPRGAAEGGVMAKSTAtsflADLKALAKnpSFILSTLgfTAVSF 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 237 ---TLARFSEAFLILKAQSIGMPIALVPLALVLMS-LAYSLSAYPAGILSDKVDRFTI----LVIGLSLLVCADLVLAFT 308
Cdd:cd17328 222 vtgALAFWAPTFFLRAFGVGDLSSADVGLIFGAITcIAGVLGVLLGGILADRLRRKTPradpLVCAVGLLAAAPFLFLAL 301
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 2416574742 309 QSVVGAGLGVVLWGL----HMGFTQGLLAKLIADTSPAELRGTAFGMFNLVTGV 358
Cdd:cd17328 302 VLALSNLLLAWVLLFlgefLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHL 355
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
250-391 |
1.88e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 40.23 E-value: 1.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 250 AQSIGMPIALVPLALVLMSLAYSLSAYPAGILSDKVDRFTILVIGLSLLVCADLVLAFTQSVVGAGLGVVLWGLHMGFTQ 329
Cdd:cd17321 23 ARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIM 102
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2416574742 330 GLLAKLIADTSPAELRGTAFGMFNLVTGVALLIASVIAGALWDFTGPRGTFLAGAGFAALTI 391
Cdd:cd17321 103 PASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVAL 164
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
258-404 |
2.00e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 39.91 E-value: 2.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 258 ALVPLALVLMSLAYSLSAYPAGILSDKVDRFTILVI-----GLSLLVCADLVLAFTQSVVGAGLGVVLWGLHMGFTQGLL 332
Cdd:cd06173 34 LLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILadllrALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPAR 113
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2416574742 333 AKLIADTSPAELRGTAFGMFNLVTGVALLIASVIAGALWDFTGPRGTFLAGAGFAALTIMGLAAVRARLPAQ 404
Cdd:cd06173 114 QALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAA 185
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
262-403 |
2.14e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 39.84 E-value: 2.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 262 LALVLMSLAYSLSAYPAGILSDKVDRFTILVIGLSLLVCADLVLAFTQSVVGAGLGVVLWGLHMGFTQGLLAKLIADTSP 341
Cdd:COG0738 47 LLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGP 126
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2416574742 342 aELRGTAFGMFNLVTGVALLIASVIAGALWDFTGPRGTFLAGAGFAALT-IMGLAAVRARLPA 403
Cdd:COG0738 127 -ETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSWHLPYLILAVLLlLLALLFLRSKLPE 188
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
41-398 |
2.32e-03 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 39.87 E-value: 2.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 41 LLPVYMVSvLGTSTFAVGIIEGIAEATASITKVFSGALSDWLGRRKFLAALGYGLAAI-TKPTFPLASSLDWLIAARFID 119
Cdd:cd17335 19 FLSVYLKQ-LGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLfFLSLFFVAQIFWLLLLLVILG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 120 RVGKGIRGAPRDALVADIAppELRGASFGLRQSLDTIGAFLGpLMAIGLM---WVTADHFQTVFWIAVLPAFLSVGVLLF 196
Cdd:cd17335 98 AFFSAPVVPLVDSITLQYL--GEERERYGKQRLWGSIGFGIA-ALLVGILidrSSTYKNYTIAFYVFAVLMLLALLLALK 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 197 LVKEPERPRELRRVRmplhrdELRRLGKS--YWWVVAVAAVFTLAR-FSEAFLILKAQSIGMPIALVPLALVLMSLAYSL 273
Cdd:cd17335 175 FPFRPKHPEPNENTG------GLLALLRNprVLAFLLVAFLMGFGHgLIYSFLFWHLQDLGGSKTLIGLLWTVGVVSEIP 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 274 SAYPAGILSDKVDRFTILVIGLsllVCADLVLAFTQSVVGAGLGVVLWGLHmGFTQGLL----AKLIADTSPAELRGTAF 349
Cdd:cd17335 249 FFFFSSRLIQRFGHVGLLYLGL---LAYVVRWLLYSFLENPWLVLPIELLH-GLTFALVwaaaVSYASAAAPPGLRATAQ 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 2416574742 350 GMFN-LVTGVALLIASVIAGALWDFTGPRGTFLAGAGFAALTIMGLAAVR 398
Cdd:cd17335 325 GLLQgLYFGLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFFLIQ 374
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
25-377 |
2.60e-03 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 39.60 E-value: 2.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 25 GLVSMLMDISSEMIHALLPVYMVSVLGTSTFAVGIIEGIAEATASITKVFSGALSDWL----GRRK---FLAALGYGLAA 97
Cdd:pfam13347 3 GSGALAAGIKYAGLATYLLYFYTDVLGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTrtrwGRRRpwlLLSAIILAVSF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 98 I---TKPTFPLASSLDWLIAARFIDRVGKGIRGAPRDALVADIAP-PELRGASFGLRQSLDTIGAFLGPLMA------IG 167
Cdd:pfam13347 83 IllfTPPELGRAPLFIWLLATYILLRIAYTFFEIPYWSLGPELTRdYDERTSLTSYRSFFSVGGGLLAAALAfplvliLG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 168 LMWVTADHFQTVFWIAVLPAFLSVGVLLFLVKEP---ERPRELRRVRMPLHRDELRRLG--KSYWWVVAVAAVFTLARF- 241
Cdd:pfam13347 163 GTGLERKGYRIFALIGAVLMLLGVIITAAGTKERvsmRSKEDTGQKEAGSLLDMLKEVFrnRAFLILLASFLLAALAMGv 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 242 SEAFLILKAQSI---GMPIALVPLALVLMSLAYS-LSAYPAGILSDKVDRFTILVIGLSLLVCAdlVLAFTQSVVGAGLG 317
Cdd:pfam13347 243 LNGLLLYYFRYVlgnGFAASAFPLVFTIGALLGIpLWPPLAKRIGKKNTYILGALITIAGFALA--LLLGPNNTLLFLVL 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2416574742 318 VVLWGLHMGFTQGLLAKLIADT-------SPAELRGTAFGMFNLVTGVALLIASVIAGALWDFTGPR 377
Cdd:pfam13347 321 YIIIGFGYGSSFFLPWSMLADVvdygelrTGKRREGTFFAMWSFISKLATGVGLGVSGLLLSAFGYN 387
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
74-200 |
3.19e-03 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 37.63 E-value: 3.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 74 FSGALSDWLGRRKFLAALGYGLAAITKPtFPLASSLDWLIAARFIDRVGKGIRGAPRDALVADIAPPELRGASFGLRQSL 153
Cdd:TIGR00880 17 LSGLLTDRFGRKPVLLVGLFIFVLSTAM-FALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEERGVALGLMSAG 95
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 2416574742 154 DTIGAFLGPLmaIGLMWVTADHFQTVFWIAVLPAFLSVGVLLFLVKE 200
Cdd:TIGR00880 96 IALGPLLGPP--LGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPE 140
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
45-196 |
5.28e-03 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 38.66 E-value: 5.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 45 YMVSVLGTSTFAVGIIEGIAEATASITKVFSGALSDWLGRRKFLAALGYGLAAITKPTFPLASSLDW---LIAARFIDRV 121
Cdd:cd17369 254 YATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFFWLLDTGSTwliVLAAVVVLGV 333
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2416574742 122 GKGIRGAPRDALVADIAPPELR--GASFGlRQSLDTIGAFLGPLMAIGLmWVTADHFQTVFWIAVLPAFLSVGVLLF 196
Cdd:cd17369 334 LHGMMYGPQAAFLAELFPTRVRytGASLG-YQLGAILGGGFAPLIATAL-VAATGSWWPVALYLAALAVISLVAALF 408
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
76-398 |
5.80e-03 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 38.31 E-value: 5.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 76 GALSDWLGRRK-FLAA-----LGYGLAAitkptfpLASSLDWLIAARFIDRVGKGIRGAPRDALVADIAPPELRGASFGL 149
Cdd:cd17502 51 GKLSDLFGRKWvLLIAivifeLGSLLCG-------LAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGY 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 150 RQSLDTIGAFLGPLmaIGLMWVTADHFQTVFWIAvlpafLSVGVLLFLvkeperprelrrvrmplhrdelrrLGKSYWWV 229
Cdd:cd17502 124 IGAVFGIASVAGPL--IGGAFTDHLSWRWCFYIN-----LPIGGLALA------------------------LLRTILLS 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 230 VAVAAVFTLARFSEA-FLILKAQSI-GMPIALVPLALVLMSLAYSLSAYPAGILSDKVDRF-TILVIGLSLLVCADLVLA 306
Cdd:cd17502 173 SIFGFLFGGALFGLIyYLPLYFQLVlGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRYkPLIVIGTILMSVGAGLLT 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 307 FTQSVVGAGLGVV---LWGLHMGFTQGLLAKLIADTSPAELRGTAFGMFNLVTGvallIASVIAGALWDftgprgTFLAG 383
Cdd:cd17502 253 TLTLDTSKWLLIGyliLLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRS----LGGTLGVAITD------VFLVA 322
|
330
....*....|....*
gi 2416574742 384 AGFAALTIMGLAAVR 398
Cdd:cd17502 323 LALAALAFLLSLFLP 337
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
262-391 |
6.71e-03 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 38.33 E-value: 6.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 262 LALVLMSLAYSLSAYPAGILSDKVDRFTILVIGLSLLVCADLVLAFTQSVVGAGLGVVLWGLHMGFTQGLLAKLIADTSP 341
Cdd:cd17323 38 LGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFT 117
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 2416574742 342 AELRGTAFGMFNLVTGVALLIASVIAGALWDFTGPRGTF---LAGAGFAALTI 391
Cdd:cd17323 118 PEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFwflAIISGFCLILI 170
|
|
| xylE |
PRK10077 |
D-xylose transporter XylE; Provisional |
42-207 |
6.96e-03 |
|
D-xylose transporter XylE; Provisional
Pssm-ID: 182225 [Multi-domain] Cd Length: 479 Bit Score: 38.52 E-value: 6.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 42 LPVYMVSVLGTSTFAVGIIEGIAEATASITKVFSGALSDW----LGRRK---------FLAALG-----YGLAAITKPTF 103
Cdd:PRK10077 38 LNTVFVAPQNLSESAANSLLGFCVASALIGCIIGGALGGYcsnrFGRRDslkiaavlfFISALGsawpeFGFTSIGPDNT 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416574742 104 PLASSLdwlIAARFIDRVGKGIRGAPRDALVADIAPPELRGASFGLRQSLDTIGAFL------GPLMAIGLMWVTADHFQ 177
Cdd:PRK10077 118 GYVPEF---VIYRIIGGIGVGLASMLSPMYIAEIAPAHIRGKLVSFNQFAIIFGQLVvyfvnyFIARSGDASWLNTDGWR 194
|
170 180 190
....*....|....*....|....*....|
gi 2416574742 178 TVFWIAVLPAFLsVGVLLFLVkePERPREL 207
Cdd:PRK10077 195 YMFASEAIPALL-FLMLLYFV--PETPRYL 221
|
|
| |
