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Conserved domains on  [gi|2427720614|ref|WP_270663367|]
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MULTISPECIES: alpha/beta fold hydrolase [unclassified Aeromonas]

Protein Classification

alpha/beta fold hydrolase( domain architecture ID 11426811)

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

PubMed:  1409539|12369917

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 3-265 2.07e-44

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


:

Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 149.38  E-value: 2.07e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427720614   3 QFMQIAGRRMAYLDEG-QGPVLLLGHSYLWDSAMWAPQVEALKGQYRCIVPELWGHGDSDAtPDGPCTLATLARDHLALL 81
Cdd:COG0596     5 RFVTVDGVRLHYREAGpDGPPVVLLHGLPGSSYEWRPLIPALAAGYRVIAPDLRGHGRSDK-PAGGYTLDDLADDLAALL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427720614  82 DALGVDDVVLVGLSIGGMWGVELARMAPGRLKGLVLMDSFVglepqitcERYLAMLAAieqlgsipapiveqvaplffah 161
Cdd:COG0596    84 DALGLERVVLVGHSMGGMVALELAARHPERVAGLVLVDEVL--------AALAEPLRR---------------------- 133

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427720614 162 qpDAALMDGFKGRLAAwpvdkvaslvavgrafVTREDRIDWLEEMALPALVMTGCEDKARPVLEGYLMAEVL-GCSFREI 240
Cdd:COG0596   134 --PGLAPEALAALLRA----------------LARTDLRERLARITVPTLVIWGEKDPIVPPALARRLAELLpNAELVVL 195

                         250       260
                  ....*....|....*....|....*
gi 2427720614 241 PLAGHISTLENPAFVNRALAEFLGA 265
Cdd:COG0596   196 PGAGHFPPLEQPEAFAAALRDFLAR 220
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 3-265 2.07e-44

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 149.38  E-value: 2.07e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427720614   3 QFMQIAGRRMAYLDEG-QGPVLLLGHSYLWDSAMWAPQVEALKGQYRCIVPELWGHGDSDAtPDGPCTLATLARDHLALL 81
Cdd:COG0596     5 RFVTVDGVRLHYREAGpDGPPVVLLHGLPGSSYEWRPLIPALAAGYRVIAPDLRGHGRSDK-PAGGYTLDDLADDLAALL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427720614  82 DALGVDDVVLVGLSIGGMWGVELARMAPGRLKGLVLMDSFVglepqitcERYLAMLAAieqlgsipapiveqvaplffah 161
Cdd:COG0596    84 DALGLERVVLVGHSMGGMVALELAARHPERVAGLVLVDEVL--------AALAEPLRR---------------------- 133

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427720614 162 qpDAALMDGFKGRLAAwpvdkvaslvavgrafVTREDRIDWLEEMALPALVMTGCEDKARPVLEGYLMAEVL-GCSFREI 240
Cdd:COG0596   134 --PGLAPEALAALLRA----------------LARTDLRERLARITVPTLVIWGEKDPIVPPALARRLAELLpNAELVVL 195

                         250       260
                  ....*....|....*....|....*
gi 2427720614 241 PLAGHISTLENPAFVNRALAEFLGA 265
Cdd:COG0596   196 PGAGHFPPLEQPEAFAAALRDFLAR 220
protocat_pcaD TIGR02427
3-oxoadipate enol-lactonase; Members of this family are 3-oxoadipate enol-lactonase. Note that ...
 16-263 7.80e-38

3-oxoadipate enol-lactonase; Members of this family are 3-oxoadipate enol-lactonase. Note that the substrate is known as 3-oxoadipate enol-lactone, 2-oxo-2,3-dihydrofuran-5-acetate, 4,5-Dihydro-5-oxofuran-2-acetate, and 5-oxo-4,5-dihydrofuran-2-acetate. The enzyme the catalyzes the fourth step in the protocatechuate degradation to beta-ketoadipate and then to succinyl-CoA and acetyl-CoA. 4-hydroxybenzoate, 3-hydroxybenzoate, and vanillate all can be converted in one step to protocatechuate. This enzyme also acts in catechol degradation. In genomes that catabolize both catechol and protocatechuate, two forms of this enzyme may be found. All members of the seed alignment for this model were chosen from within protocatechuate degradation operons of at least three genes of the pathway, from genomes with the complete pathway through beta-ketoadipate. [Energy metabolism, Other]


Pssm-ID: 131480 [Multi-domain]  Cd Length: 251  Bit Score: 133.25  E-value: 7.80e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427720614  16 DEGQGPVLLLGHSYLWDSAMWAPQVEALKGQYRCIVPELWGHGDSDAtPDGPCTLATLARDHLALLDALGVDDVVLVGLS 95
Cdd:TIGR02427   9 AADGAPVLVFINSLGTDLRMWDPVLPALTPDFRVLRYDKRGHGLSDA-PEGPYSIEDLADDVLALLDHLGIERAVFCGLS 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427720614  96 IGGMWGVELARMAPGRLKGLVLMDSfvglEPQI-TCERYLAMLAAIEQLGSipAPIVEQVAPLFFA---HQPDAALMDGF 171
Cdd:TIGR02427  88 LGGLIAQGLAARRPDRVRALVLSNT----AAKIgTPESWNARIAAVRAEGL--AALADAVLERWFTpgfREAHPARLDLY 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427720614 172 KGRLAAWPVDKVASLVAVGRAFvtreDRIDWLEEMALPALVMTGCEDKARPVLEGYLMAE-VLGCSFREIPLAGHISTLE 250
Cdd:TIGR02427 162 RNMLVRQPPDGYAGCCAAIRDA----DFRDRLGAIAVPTLCIAGDQDGSTPPELVREIADlVPGARFAEIRGAGHIPCVE 237

                         250
                  ....*....|...
gi 2427720614 251 NPAFVNRALAEFL 263
Cdd:TIGR02427 238 QPEAFNAALRDFL 250
PRK03592 PRK03592
haloalkane dehalogenase; Provisional
 2-122 3.29e-21

haloalkane dehalogenase; Provisional


Pssm-ID: 235135  Cd Length: 295  Bit Score: 90.44  E-value: 3.29e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427720614   2 KQFMQIAGRRMAYLDEGQGPVLLLGH-----SYLWDSAMwaPQVEalkGQYRCIVPELWGHGDSDaTPDGPCTLATLARD 76
Cdd:PRK03592    9 MRRVEVLGSRMAYIETGEGDPIVFLHgnptsSYLWRNII--PHLA---GLGRCLAPDLIGMGASD-KPDIDYTFADHARY 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2427720614  77 HLALLDALGVDDVVLVGLSIGGMWGVELARMAPGRLKGLVLMDSFV 122
Cdd:PRK03592   83 LDAWFDALGLDDVVLVGHDWGSALGFDWAARHPDRVRGIAFMEAIV 128
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 21-252 3.43e-17

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 78.32  E-value: 3.43e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427720614  21 PVLLLGHSYLWDSAMWAPQVEAL-KGQYRCIVPELWGHGDSDATPD-GPCTLATLARDHLALLDALGVDDVVLVGLSIGG 98
Cdd:pfam00561   1 PPVLLLHGLPGSSDLWRKLAPALaRDGFRVIALDLRGFGKSSRPKAqDDYRTDDLAEDLEYILEALGLEKVNLVGHSMGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427720614  99 MWGVELARMAPGRLKGLVLMDSFVGLEPQITCERYLAML---------AAIEQLGSIPAPIVEqVAPLFFAHQPDAALMD 169
Cdd:pfam00561  81 LIALAYAAKYPDRVKALVLLGALDPPHELDEADRFILALfpgffdgfvADFAPNPLGRLVAKL-LALLLLRLRLLKALPL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427720614 170 gFKGRLAAWPVDKVASLVAVG---RAFVTREDRIDWLEEMALPALVMTGCEDKARPVLEGYLMAEVLGCSFRE-IPLAGH 245
Cdd:pfam00561 160 -LNKRFPSGDYALAKSLVTGAllfIETWSTELRAKFLGRLDEPTLIIWGDQDPLVPPQALEKLAQLFPNARLVvIPDAGH 238


                  ....*..
gi 2427720614 246 ISTLENP 252
Cdd:pfam00561 239 FAFLEGP 245
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 3-265 2.07e-44

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 149.38  E-value: 2.07e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427720614   3 QFMQIAGRRMAYLDEG-QGPVLLLGHSYLWDSAMWAPQVEALKGQYRCIVPELWGHGDSDAtPDGPCTLATLARDHLALL 81
Cdd:COG0596     5 RFVTVDGVRLHYREAGpDGPPVVLLHGLPGSSYEWRPLIPALAAGYRVIAPDLRGHGRSDK-PAGGYTLDDLADDLAALL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427720614  82 DALGVDDVVLVGLSIGGMWGVELARMAPGRLKGLVLMDSFVglepqitcERYLAMLAAieqlgsipapiveqvaplffah 161
Cdd:COG0596    84 DALGLERVVLVGHSMGGMVALELAARHPERVAGLVLVDEVL--------AALAEPLRR---------------------- 133

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427720614 162 qpDAALMDGFKGRLAAwpvdkvaslvavgrafVTREDRIDWLEEMALPALVMTGCEDKARPVLEGYLMAEVL-GCSFREI 240
Cdd:COG0596   134 --PGLAPEALAALLRA----------------LARTDLRERLARITVPTLVIWGEKDPIVPPALARRLAELLpNAELVVL 195

                         250       260
                  ....*....|....*....|....*
gi 2427720614 241 PLAGHISTLENPAFVNRALAEFLGA 265
Cdd:COG0596   196 PGAGHFPPLEQPEAFAAALRDFLAR 220
protocat_pcaD TIGR02427
3-oxoadipate enol-lactonase; Members of this family are 3-oxoadipate enol-lactonase. Note that ...
 16-263 7.80e-38

3-oxoadipate enol-lactonase; Members of this family are 3-oxoadipate enol-lactonase. Note that the substrate is known as 3-oxoadipate enol-lactone, 2-oxo-2,3-dihydrofuran-5-acetate, 4,5-Dihydro-5-oxofuran-2-acetate, and 5-oxo-4,5-dihydrofuran-2-acetate. The enzyme the catalyzes the fourth step in the protocatechuate degradation to beta-ketoadipate and then to succinyl-CoA and acetyl-CoA. 4-hydroxybenzoate, 3-hydroxybenzoate, and vanillate all can be converted in one step to protocatechuate. This enzyme also acts in catechol degradation. In genomes that catabolize both catechol and protocatechuate, two forms of this enzyme may be found. All members of the seed alignment for this model were chosen from within protocatechuate degradation operons of at least three genes of the pathway, from genomes with the complete pathway through beta-ketoadipate. [Energy metabolism, Other]


Pssm-ID: 131480 [Multi-domain]  Cd Length: 251  Bit Score: 133.25  E-value: 7.80e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427720614  16 DEGQGPVLLLGHSYLWDSAMWAPQVEALKGQYRCIVPELWGHGDSDAtPDGPCTLATLARDHLALLDALGVDDVVLVGLS 95
Cdd:TIGR02427   9 AADGAPVLVFINSLGTDLRMWDPVLPALTPDFRVLRYDKRGHGLSDA-PEGPYSIEDLADDVLALLDHLGIERAVFCGLS 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427720614  96 IGGMWGVELARMAPGRLKGLVLMDSfvglEPQI-TCERYLAMLAAIEQLGSipAPIVEQVAPLFFA---HQPDAALMDGF 171
Cdd:TIGR02427  88 LGGLIAQGLAARRPDRVRALVLSNT----AAKIgTPESWNARIAAVRAEGL--AALADAVLERWFTpgfREAHPARLDLY 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427720614 172 KGRLAAWPVDKVASLVAVGRAFvtreDRIDWLEEMALPALVMTGCEDKARPVLEGYLMAE-VLGCSFREIPLAGHISTLE 250
Cdd:TIGR02427 162 RNMLVRQPPDGYAGCCAAIRDA----DFRDRLGAIAVPTLCIAGDQDGSTPPELVREIADlVPGARFAEIRGAGHIPCVE 237

                         250
                  ....*....|...
gi 2427720614 251 NPAFVNRALAEFL 263
Cdd:TIGR02427 238 QPEAFNAALRDFL 250
PRK03592 PRK03592
haloalkane dehalogenase; Provisional
 2-122 3.29e-21

haloalkane dehalogenase; Provisional


Pssm-ID: 235135  Cd Length: 295  Bit Score: 90.44  E-value: 3.29e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427720614   2 KQFMQIAGRRMAYLDEGQGPVLLLGH-----SYLWDSAMwaPQVEalkGQYRCIVPELWGHGDSDaTPDGPCTLATLARD 76
Cdd:PRK03592    9 MRRVEVLGSRMAYIETGEGDPIVFLHgnptsSYLWRNII--PHLA---GLGRCLAPDLIGMGASD-KPDIDYTFADHARY 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2427720614  77 HLALLDALGVDDVVLVGLSIGGMWGVELARMAPGRLKGLVLMDSFV 122
Cdd:PRK03592   83 LDAWFDALGLDDVVLVGHDWGSALGFDWAARHPDRVRGIAFMEAIV 128
PRK14875 PRK14875
acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional
 3-265 2.98e-20

acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional


Pssm-ID: 184875 [Multi-domain]  Cd Length: 371  Bit Score: 88.85  E-value: 2.98e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427720614   3 QFMQIAGRRMAYLDEGQG---PVLLLgHSYLWDSAMWAPQVEALKGQYRCIVPELWGHGDSDATPDGPcTLATLARDHLA 79
Cdd:PRK14875  112 RKARIGGRTVRYLRLGEGdgtPVVLI-HGFGGDLNNWLFNHAALAAGRPVIALDLPGHGASSKAVGAG-SLDELAAAVLA 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427720614  80 LLDALGVDDVVLVGLSIGGMWGVELARMAPGRLKGLVLMDSfVGLEPQI---------TCERYLAMLAAIEQLGSIPAPI 150
Cdd:PRK14875  190 FLDALGIERAHLVGHSMGGAVALRLAARAPQRVASLTLIAP-AGLGPEIngdyidgfvAAESRRELKPVLELLFADPALV 268

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427720614 151 VEQVAplffahqpDAAL----MDGFKGRLAAWpvdkVASLVAVGRafvTREDRIDWLEEMALPALVMTGCEDKARPV--- 223
Cdd:PRK14875  269 TRQMV--------EDLLkykrLDGVDDALRAL----ADALFAGGR---QRVDLRDRLASLAIPVLVIWGEQDRIIPAaha 333

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 2427720614 224 --LEGYLMAEVLgcsfreiPLAGHISTLENPAFVNRALAEFLGA 265
Cdd:PRK14875  334 qgLPDGVAVHVL-------PGAGHMPQMEAAADVNRLLAEFLGK 370
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 21-252 3.43e-17

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 78.32  E-value: 3.43e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427720614  21 PVLLLGHSYLWDSAMWAPQVEAL-KGQYRCIVPELWGHGDSDATPD-GPCTLATLARDHLALLDALGVDDVVLVGLSIGG 98
Cdd:pfam00561   1 PPVLLLHGLPGSSDLWRKLAPALaRDGFRVIALDLRGFGKSSRPKAqDDYRTDDLAEDLEYILEALGLEKVNLVGHSMGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427720614  99 MWGVELARMAPGRLKGLVLMDSFVGLEPQITCERYLAML---------AAIEQLGSIPAPIVEqVAPLFFAHQPDAALMD 169
Cdd:pfam00561  81 LIALAYAAKYPDRVKALVLLGALDPPHELDEADRFILALfpgffdgfvADFAPNPLGRLVAKL-LALLLLRLRLLKALPL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427720614 170 gFKGRLAAWPVDKVASLVAVG---RAFVTREDRIDWLEEMALPALVMTGCEDKARPVLEGYLMAEVLGCSFRE-IPLAGH 245
Cdd:pfam00561 160 -LNKRFPSGDYALAKSLVTGAllfIETWSTELRAKFLGRLDEPTLIIWGDQDPLVPPQALEKLAQLFPNARLVvIPDAGH 238


                  ....*..
gi 2427720614 246 ISTLENP 252
Cdd:pfam00561 239 FAFLEGP 245
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
6-150 2.18e-12

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 64.64  E-value: 2.18e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427720614   6 QIAGRRMAYLDEGQGPVLLLgHSYLWDSAMWAPQVEALKGQ-YRCIVPELWGHGDSDATPDGPCTLATLARDHLALLDAL 84
Cdd:COG2267    15 RLRGRRWRPAGSPRGTVVLV-HGLGEHSGRYAELAEALAAAgYAVLAFDLRGHGRSDGPRGHVDSFDDYVDDLRAALDAL 93

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427720614  85 ---GVDDVVLVGLSIGGMWGVELARMAPGRLKGLVLMDSFVGLEPQITC-ERYLAMLAAIEQLGSIPAPI 150
Cdd:COG2267    94 rarPGLPVVLLGHSMGGLIALLYAARYPDRVAGLVLLAPAYRADPLLGPsARWLRALRLAEALARIDVPV 163
PRK03204 PRK03204
haloalkane dehalogenase; Provisional
 11-173 5.98e-11

haloalkane dehalogenase; Provisional


Pssm-ID: 179554 [Multi-domain]  Cd Length: 286  Bit Score: 61.41  E-value: 5.98e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427720614  11 RMAYLDEGQGPVLLLGHSYLWDSAMWAPQVEALKGQYRCIVPELWGHGDSDaTPDG-PCTLATLARDHLALLDALGVDDV 89
Cdd:PRK03204   25 RIHYIDEGTGPPILLCHGNPTWSFLYRDIIVALRDRFRCVAPDYLGFGLSE-RPSGfGYQIDEHARVIGEFVDHLGLDRY 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427720614  90 VLVGLSIGGMWGVELARMAPGRLKGLVLMDSFvgLEPQITceryLAMLAAIEQLGSIPAP--------IVEQVAPLFFAH 161
Cdd:PRK03204  104 LSMGQDWGGPISMAVAVERADRVRGVVLGNTW--FWPADT----LAMKAFSRVMSSPPVQyailrrnfFVERLIPAGTEH 177

                         170
                  ....*....|..
gi 2427720614 162 QPDAALMDGFKG 173
Cdd:PRK03204  178 RPSSAVMAHYRA 189
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
5-263 1.31e-08

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 54.18  E-value: 1.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427720614   5 MQIAGRRMAYLDEGQGPVLLLgHSYL---WDSAMWAPQVEAlKGqYRCIVPELWGHGDSDATpdgpctLATL-------- 73
Cdd:COG1647     1 MKILGAEPFFLEGGRKGVLLL-HGFTgspAEMRPLAEALAK-AG-YTVYAPRLPGHGTSPED------LLKTtwedwled 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427720614  74 ARDHLALLdALGVDDVVLVGLSIGGMWGVELARMAPgRLKGLVLMDSFVglepqitcerylamlaAIEQLGSIPAPIVEQ 153
Cdd:COG1647    72 VEEAYEIL-KAGYDKVIVIGLSMGGLLALLLAARYP-DVAGLVLLSPAL----------------KIDDPSAPLLPLLKY 133

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427720614 154 VAPLFFAHQPDAALMDGFKGRLAAWPVDKVASLVAVGRAfvTREDridwLEEMALPALVMTGCEDKARPVLEGYLMAEVL 233
Cdd:COG1647   134 LARSLRGIGSDIEDPEVAEYAYDRTPLRALAELQRLIRE--VRRD----LPKITAPTLIIQSRKDEVVPPESARYIYERL 207

                         250       260       270
                  ....*....|....*....|....*....|....
gi 2427720614 234 GCS---FREIPLAGHISTLENPA-FVNRALAEFL 263
Cdd:COG1647   208 GSPdkeLVWLEDSGHVITLDKDReEVAEEILDFL 241
PRK00870 PRK00870
haloalkane dehalogenase; Provisional
 11-121 2.54e-08

haloalkane dehalogenase; Provisional


Pssm-ID: 179147 [Multi-domain]  Cd Length: 302  Bit Score: 53.82  E-value: 2.54e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427720614  11 RMAYLDEGQ--GPVLLLGH-----SYLWdSAMWAPQVEAlkgQYRCIVPELWGHGDSDAtpdgPCTLA--TLARdHL--- 78
Cdd:PRK00870   35 RMHYVDEGPadGPPVLLLHgepswSYLY-RKMIPILAAA---GHRVIAPDLIGFGRSDK----PTRREdyTYAR-HVewm 105

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2427720614  79 -ALLDALGVDDVVLVGLSIGGMWGVELARMAPGRLKGLVLMDSF 121
Cdd:PRK00870  106 rSWFEQLDLTDVTLVCQDWGGLIGLRLAAEHPDRFARLVVANTG 149
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 41-258 8.30e-08

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 51.32  E-value: 8.30e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427720614  41 EALKGQYRCIVPELWGHGDSDATPDgpcTLATLARDHLALLDALGVDDVVLVGLSIGGMWGVELARMAPGRlkgLVLMDS 120
Cdd:pfam12697  16 ALLAAGVAVLAPDLPGHGSSSPPPL---DLADLADLAALLDELGAARPVVLVGHSLGGAVALAAAAAALVV---GVLVAP 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427720614 121 FVGLEPQITcerylAMLAAIEQLGSIPAPiveqvaPLFFAHQPDAALMDGFKGRLAAWPVDKVASLVAVGRAFVTREDRI 200
Cdd:pfam12697  90 LAAPPGLLA-----ALLALLARLGAALAA------PAWLAAESLARGFLDDLPADAEWAAALARLAALLAALALLPLAAW 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2427720614 201 dwleEMALPALVMTGCEDKARPVLEGYLMAEVLGCSFREIPLAGHiSTLENPAFVNRA 258
Cdd:pfam12697 159 ----RDLPVPVLVLAEEDRLVPELAQRLLAALAGARLVVLPGAGH-LPLDDPEEVAEA 211
PLN02980 PLN02980
2-oxoglutarate decarboxylase/ hydro-lyase/ magnesium ion binding / thiamin pyrophosphate ...
 16-263 2.56e-06

2-oxoglutarate decarboxylase/ hydro-lyase/ magnesium ion binding / thiamin pyrophosphate binding


Pssm-ID: 215530 [Multi-domain]  Cd Length: 1655  Bit Score: 48.70  E-value: 2.56e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427720614   16 DEGQGPVLLLGHSYLWDSAMWAPQVEALKGQYRCIVPELWGHGDSDATPDGP-------CTLATLARDHLALLDALGVDD 88
Cdd:PLN02980  1367 QNAEGSVVLFLHGFLGTGEDWIPIMKAISGSARCISIDLPGHGGSKIQNHAKetqteptLSVELVADLLYKLIEHITPGK 1446

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427720614   89 VVLVGLSIGGMWGVELARMAPGRLKGLVLMDSFVGLEPQITCERYLAMLAAIEQLgsipapIVEQVAPLFFAHQPDAALM 168
Cdd:PLN02980  1447 VTLVGYSMGARIALYMALRFSDKIEGAVIISGSPGLKDEVARKIRSAKDDSRARM------LIDHGLEIFLENWYSGELW 1520

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427720614  169 DGFKG----------RLAAWPVDKVASLVA---VGRAFVTREDridwLEEMALPALVMTGCEDKARPVLEGYLMAEVLG- 234
Cdd:PLN02980  1521 KSLRNhphfnkivasRLLHKDVPSLAKLLSdlsIGRQPSLWED----LKQCDTPLLLVVGEKDVKFKQIAQKMYREIGKs 1596

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|
gi 2427720614  235 -----------CSFREIPLAGHISTLENPAFVNRALAEFL 263
Cdd:PLN02980  1597 kesgndkgkeiIEIVEIPNCGHAVHLENPLPVIRALRKFL 1636
PLN02824 PLN02824
hydrolase, alpha/beta fold family protein
 18-119 1.55e-05

hydrolase, alpha/beta fold family protein


Pssm-ID: 178419 [Multi-domain]  Cd Length: 294  Bit Score: 45.50  E-value: 1.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427720614  18 GQGPVLLLGHSYLWDSAMWAPQVEALKGQYRCIVPELWGHGDSD------ATPDGPCTLATLARDHLALLDALGVDDVVL 91
Cdd:PLN02824   27 TSGPALVLVHGFGGNADHWRKNTPVLAKSHRVYAIDLLGYGYSDkpnprsAPPNSFYTFETWGEQLNDFCSDVVGDPAFV 106

                          90       100
                  ....*....|....*....|....*...
gi 2427720614  92 VGLSIGGMWGVELARMAPGRLKGLVLMD 119
Cdd:PLN02824  107 ICNSVGGVVGLQAAVDAPELVRGVMLIN 134
PRK05855 PRK05855
SDR family oxidoreductase;
9-101 2.62e-05

SDR family oxidoreductase;


Pssm-ID: 235628 [Multi-domain]  Cd Length: 582  Bit Score: 44.97  E-value: 2.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427720614   9 GRRMAYLDEGQ--GPVLLLGHSYLWDSAMWAPQVEALKGQYRCIVPELWGHGDSDA-TPDGPCTLATLARDHLALLDALG 85
Cdd:PRK05855   12 GVRLAVYEWGDpdRPTVVLVHGYPDNHEVWDGVAPLLADRFRVVAYDVRGAGRSSApKRTAAYTLARLADDFAAVIDAVS 91

                          90
                  ....*....|....*.
gi 2427720614  86 VDDVVLVglsIGGMWG 101
Cdd:PRK05855   92 PDRPVHL---LAHDWG 104
PRK10673 PRK10673
esterase;
57-119 3.64e-05

esterase;


Pssm-ID: 182637 [Multi-domain]  Cd Length: 255  Bit Score: 43.95  E-value: 3.64e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2427720614  57 HGDSDATPDgpCTLATLARDHLALLDALGVDDVVLVGLSIGGMWGVELARMAPGRLKGLVLMD 119
Cdd:PRK10673   53 HGLSPRDPV--MNYPAMAQDLLDTLDALQIEKATFIGHSMGGKAVMALTALAPDRIDKLVAID 113
PLN02578 PLN02578
hydrolase
 4-120 1.02e-03

hydrolase


Pssm-ID: 215315 [Multi-domain]  Cd Length: 354  Bit Score: 39.82  E-value: 1.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427720614   4 FMQIAGRRMAYLDEGQGPVLLLGHSYLWDSAMWAPQVEALKGQYRCIVPELWGHGDSD-ATPDGPctlATLARDHLA-LL 81
Cdd:PLN02578   70 FWTWRGHKIHYVVQGEGLPIVLIHGFGASAFHWRYNIPELAKKYKVYALDLLGFGWSDkALIEYD---AMVWRDQVAdFV 146

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2427720614  82 DALGVDDVVLVGLSIGGMWGVELARMAPGRLKGLVLMDS 120
Cdd:PLN02578  147 KEVVKEPAVLVGNSLGGFTALSTAVGYPELVAGVALLNS 185
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
 16-124 2.95e-03

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 36.35  E-value: 2.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427720614  16 DEGQGPVLLLgHSYLWDSAMWAPQVEALKGQ-YRCIVPELwghgdsdatPDGPCTLATLARDHLALLDAL----GVDDVV 90
Cdd:COG1075     2 AATRYPVVLV-HGLGGSAASWAPLAPRLRAAgYPVYALNY---------PSTNGSIEDSAEQLAAFVDAVlaatGAEKVD 71

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2427720614  91 LVGLSIGGMwgveLARMAPGRLKGLVLMDSFVGL 124
Cdd:COG1075    72 LVGHSMGGL----VARYYLKRLGGAAKVARVVTL 101
PLN02679 PLN02679
hydrolase, alpha/beta fold family protein
 11-119 3.64e-03

hydrolase, alpha/beta fold family protein


Pssm-ID: 178283 [Multi-domain]  Cd Length: 360  Bit Score: 38.28  E-value: 3.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427720614  11 RMAYLDEGQG------PVLLLGHSYLWDSAMWAPQVEALKGQYRCIVPELWGHGDSDATPDGPCTLATLARDHLALLDAL 84
Cdd:PLN02679   73 SINYLVKGSPevtssgPPVLLVHGFGASIPHWRRNIGVLAKNYTVYAIDLLGFGASDKPPGFSYTMETWAELILDFLEEV 152

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2427720614  85 GVDDVVLVGLSIGGMWGVELARMAPGRL-KGLVLMD 119
Cdd:PLN02679  153 VQKPTVLIGNSVGSLACVIAASESTRDLvRGLVLLN 188
PRK08775 PRK08775
homoserine O-succinyltransferase;
60-267 5.21e-03

homoserine O-succinyltransferase;


Pssm-ID: 181553 [Multi-domain]  Cd Length: 343  Bit Score: 37.85  E-value: 5.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427720614  60 SDATPDGPCTLATLARDHLALLDALGVDDV-VLVGLSIGGMWGVELARMAPGRLKGLVLMDSFVGLEPQITCERYL---- 134
Cdd:PRK08775  110 ADGSLDVPIDTADQADAIALLLDALGIARLhAFVGYSYGALVGLQFASRHPARVRTLVVVSGAHRAHPYAAAWRALqrra 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427720614 135 -----------AMLAAIEQLGSIPAPIVEQVAPLFFAHQPDAAlmdgfkGRLAAWPVDkvaSLVAVGRAFVTREDRIDWL 203
Cdd:PRK08775  190 valgqlqcaekHGLALARQLAMLSYRTPEEFEERFDAPPEVIN------GRVRVAAED---YLDAAGAQYVARTPVNAYL 260

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427720614 204 -------------EEMALPALVMTGCEDKARPVLEGYLMAEVLGC--SFREIP-LAGHISTLENPAFVNRALAEFLGAIG 267
Cdd:PRK08775  261 rlsesidlhrvdpEAIRVPTVVVAVEGDRLVPLADLVELAEGLGPrgSLRVLRsPYGHDAFLKETDRIDAILTTALRSTG 340
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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