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Conserved domains on  [gi|2427732019|ref|WP_270671113|]
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DnaB-like helicase C-terminal domain-containing protein [Aeromonas sp. QDB33]

Protein Classification

P-loop NTPase family protein( domain architecture ID 1562424)

P-loop NTPase (nucleoside triphosphate hydrolase) family protein contains two conserved sequence signatures, the Walker A motif (the P-loop proper) and Walker B motif which bind, respectively, the beta and gamma phosphate moieties of the bound nucleotide (typically ATP or GTP), and a Mg(2+) cation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
P-loop_NTPase super family cl38936
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ...
 157-410 1.01e-83

P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.


The actual alignment was detected with superfamily member cd00984:

Pssm-ID: 476819 [Multi-domain]  Cd Length: 256  Bit Score: 257.44  E-value: 1.01e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 157 GYVTGCAGIDEAFGRLKGGDLVVIAARPGMGKTELALKINKHIAQSVGCASLIVSLEMSHQQIGERLLSDTSQLPVDVFD 236
Cdd:cd00984     1 GLPTGFTDLDKLTGGLQPGDLIIIAARPSMGKTAFALNIAENIALDEGLPVLFFSLEMSAEQLAERLLSSESGVSLSKLR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 237 NPdLLSLESiMDKLRRSAEEYQDLPIYLQEVTNATHVDVCSSVRQFAEEVSNLGLLTIDHVGL--HKTIGTSRVEAVGDM 314
Cdd:cd00984    81 TG-RLDDED-WERLTAAMGELSELPLYIDDTPGLTVDEIRAKARRLKREHGGLGLIVIDYLQLirGSKRAENRQQEVAEI 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 315 TRAYKMLARELGIPVLLLCQLNRNLEMRDDKRPMLSDLRESGAIEQDADRIVFIYRDSVYDDKSGWGSVAELINGKRRRG 394
Cdd:cd00984   159 SRSLKALAKELNVPVIALSQLNRGVESRTDKRPMLSDLRESGSIEQDADVVIFLYRDEYYDKDSEDKGIAEIIIAKNRNG 238

                         250
                  ....*....|....*...
gi 2427732019 395 EAQSSYLDFKAGH--FCD 410
Cdd:cd00984   239 PTGTVYLAFNPEYtrFTD 256
 
Name Accession Description Interval E-value
DnaB_C cd00984
C-terminal domain of DnaB helicase; DnaB helicase C-terminal domain. The hexameric helicase ...
 157-410 1.01e-83

C-terminal domain of DnaB helicase; DnaB helicase C-terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This C-terminal domain contains an ATP-binding site and is therefore probably the site of ATP hydrolysis.


Pssm-ID: 410864 [Multi-domain]  Cd Length: 256  Bit Score: 257.44  E-value: 1.01e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 157 GYVTGCAGIDEAFGRLKGGDLVVIAARPGMGKTELALKINKHIAQSVGCASLIVSLEMSHQQIGERLLSDTSQLPVDVFD 236
Cdd:cd00984     1 GLPTGFTDLDKLTGGLQPGDLIIIAARPSMGKTAFALNIAENIALDEGLPVLFFSLEMSAEQLAERLLSSESGVSLSKLR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 237 NPdLLSLESiMDKLRRSAEEYQDLPIYLQEVTNATHVDVCSSVRQFAEEVSNLGLLTIDHVGL--HKTIGTSRVEAVGDM 314
Cdd:cd00984    81 TG-RLDDED-WERLTAAMGELSELPLYIDDTPGLTVDEIRAKARRLKREHGGLGLIVIDYLQLirGSKRAENRQQEVAEI 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 315 TRAYKMLARELGIPVLLLCQLNRNLEMRDDKRPMLSDLRESGAIEQDADRIVFIYRDSVYDDKSGWGSVAELINGKRRRG 394
Cdd:cd00984   159 SRSLKALAKELNVPVIALSQLNRGVESRTDKRPMLSDLRESGSIEQDADVVIFLYRDEYYDKDSEDKGIAEIIIAKNRNG 238

                         250
                  ....*....|....*...
gi 2427732019 395 EAQSSYLDFKAGH--FCD 410
Cdd:cd00984   239 PTGTVYLAFNPEYtrFTD 256
DnaB COG0305
Replicative DNA helicase [Replication, recombination and repair];
30-395 2.05e-80

Replicative DNA helicase [Replication, recombination and repair];


Pssm-ID: 440074 [Multi-domain]  Cd Length: 429  Bit Score: 255.00  E-value: 2.05e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019  30 AIEFLVDHETPVTQDTVAAYFRDMGHHE-------LAEwLVAELPLQEddgNLLAFAKKLADYHeCQRS-VQAMKNVLAN 101
Cdd:COG0305    42 AILDLYERGEPIDLVTVAEELEKRGELEevggaayLAE-LAENVPSAA---NIEYYARIVKEKA-LLRRlIEAGTEIVEL 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 102 -LNTATDCADVLlrlQKVASTIGRVTQGRQA--PLRIGTVMEGLLEDAERLAAS-GQVEGYVTGCAGIDEAFGRLKGGDL 177
Cdd:COG0305   117 aYDEDEDVDELL---DEAEQKIFEIAEKRSSkgFVSISDILKEALERIEELYKNgGGITGVPTGFTDLDKLTGGLQPGDL 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 178 VVIAARPGMGKTELALKINKHIAQSVGCASLIVSLEMSHQQIGERLLSDTSQLPVDVFDNPDLLSLEsiMDKLRRSAEEY 257
Cdd:COG0305   194 IILAARPSMGKTAFALNIARNAAIKEGKPVAIFSLEMSAEQLVMRLLSSEARIDSSKLRTGKLSDED--WERLSSAAGEL 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 258 QDLPIYLQEVTNATHVDVCSSVRQFAEEvSNLGLLTIDHVGLHK--TIGTSRVEAVGDMTRAYKMLARELGIPVLLLCQL 335
Cdd:COG0305   272 SEAPIYIDDTPGLTIAEIRAKARRLKRE-HGLGLIVIDYLQLMSgsGRSENRQQEISEISRSLKALAKELNVPVIALSQL 350

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 336 NRNLEMRDDKRPMLSDLRESGAIEQDADRIVFIYRDSVYDDKSGWGSVAELINGKRRRGE 395
Cdd:COG0305   351 SRAVEQRTDKRPQLSDLRESGSIEQDADVVMFLYRDEYYNPDSEDKGIAEIIIAKQRNGP 410
DnaB_C pfam03796
DnaB-like helicase C terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at ...
 160-395 5.31e-80

DnaB-like helicase C terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at the Escherichia coli chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This C-terminal domain contains an ATP-binding site and is therefore probably the site of ATP hydrolysis.


Pssm-ID: 427509 [Multi-domain]  Cd Length: 254  Bit Score: 247.71  E-value: 5.31e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 160 TGCAGIDEAFGRLKGGDLVVIAARPGMGKTELALKINKHIAQSVGCASLIVSLEMSHQQIGERLLSDTSQLPVDVFDNPD 239
Cdd:pfam03796   4 TGFTDLDRLTGGLQPGDLIIIAARPSMGKTAFALNIARNAAVKHKKPVAIFSLEMSAEQLVMRLLASEAGVDSQKLRTGQ 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 240 LLSLEsiMDKLRRSAEEYQDLPIYLQEVTNATHVDVCSSVRQFAEEvSNLGLLTIDHVGL--HKTIGTSRVEAVGDMTRA 317
Cdd:pfam03796  84 LTDED--WEKLAKAAGRLSEAPLYIDDTPGLSIAEIRAKARRLKRE-HGLGLIVIDYLQLmsGGSRGENRQQEISEISRS 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2427732019 318 YKMLARELGIPVLLLCQLNRNLEMRDDKRPMLSDLRESGAIEQDADRIVFIYRDSVYDDKSGwGSVAELINGKRRRGE 395
Cdd:pfam03796 161 LKALAKELNVPVIALSQLSRAVEQRTDKRPQLSDLRESGAIEQDADVVMFLYRDEYYNPKEP-EGKAEIIIAKQRNGP 237
DnaB TIGR00665
replicative DNA helicase; This model describes the helicase DnaB, a homohexameric protein ...
 30-394 9.15e-73

replicative DNA helicase; This model describes the helicase DnaB, a homohexameric protein required for DNA replication. The homohexamer can form a ring around a single strand of DNA near a replication fork. An intein of > 400 residues is found at a conserved location in DnaB of Synechocystis PCC6803, Rhodothermus marinus (both experimentally confirmed), and Mycobacterium tuberculosis. The intein removes itself by a self-splicing reaction. The seed alignment contains inteins so that the model built from the seed alignment will model a low cost at common intein insertion sites. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273206 [Multi-domain]  Cd Length: 432  Bit Score: 235.01  E-value: 9.15e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019  30 AIEFLVDHETPVTQDTVAAYFRDMGHHE-------LAEwLVAELPLQEddgNLLAFAKKLADyhecqRSV-----QAMKN 97
Cdd:TIGR00665  45 AILDLYEKGEPIDLVTVAEELEKDGELEevgglayLAE-LASNVPSAA---NIEYYAEIVKE-----KAIlrrliQAGTE 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019  98 VLANLNTATDCADVLLrlQKVASTIGRVTQGR--QAPLRIGTVMEGLLEDAERLAAS-GQVEGYVTGCAGIDEAFGRLKG 174
Cdd:TIGR00665 116 IVELAYDPTGDVEELL--DEAEQKIFEIAESRtsKGFKSIKEILKEAVEEIEELYERkGGITGVPTGFTDLDKLTSGLQP 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 175 GDLVVIAARPGMGKTELALKINKHIAQSVGCASLIVSLEMSHQQIGERLLSDTSQLPVDVFDNPDLLSLEsiMDKLRRSA 254
Cdd:TIGR00665 194 SDLIILAARPSMGKTAFALNIAENAAIKEGKPVAFFSLEMSAEQLVMRMLSSESRVDSQKLRTGRLSDED--WEKLTEAA 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 255 EEYQDLPIYLQEVTNATHVDVCSSVRQFAEEvSNLGLLTIDHVGL--HKTIGTSRVEAVGDMTRAYKMLARELGIPVLLL 332
Cdd:TIGR00665 272 GELSEAPLYIDDTPGLTITELRAKARRLKRE-HGLGLIVIDYLQLmsGSGRSENRQQEVSEISRSLKALAKELNVPVIAL 350

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2427732019 333 CQLNRNLEMRDDKRPMLSDLRESGAIEQDADRIVFIYRDSVYDDKSGWGSVAELINGKRRRG 394
Cdd:TIGR00665 351 SQLSRSVEQREDKRPQLSDLRESGSIEQDADIVMFLYRDEYYNPDSEDKGIAEIIIAKQRNG 412
PRK08506 PRK08506
replicative DNA helicase; Provisional
 138-427 3.99e-58

replicative DNA helicase; Provisional


Pssm-ID: 236278 [Multi-domain]  Cd Length: 472  Bit Score: 197.93  E-value: 3.99e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 138 VMEGLLEDAERLAASGQvegyvTGCAGIDEAFGRL-------KGGDLVVIAARPGMGKTELALK-INKHIAQSVGCAslI 209
Cdd:PRK08506  153 VIESTMEHIKKQKRLGN-----KDIIGLDTGFVELnkmtkgfNKGDLIIIAARPSMGKTTLCLNmALKALNQDKGVA--F 225

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 210 VSLEMSHQQIGERLLSDTSQLPVDVFDNPDLLSLEsiMDKLRRSAEEYQDLPIYLQEVTNATHVDVCSSVRQFAEEVSNL 289
Cdd:PRK08506  226 FSLEMPAEQLMLRMLSAKTSIPLQNLRTGDLDDDE--WERLSDACDELSKKKLFVYDSGYVNIHQVRAQLRKLKSQHPEI 303

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 290 GLLTIDHVGLHKTIG--TSRVEAVGDMTRAYKMLARELGIPVLLLCQLNRNLEMRDDKRPMLSDLRESGAIEQDADRIVF 367
Cdd:PRK08506  304 GLAVIDYLQLMSGSGnfKDRHLQISEISRGLKLLARELDIPIIALSQLNRSLESRADKRPMLSDLRESGAIEQDADIILF 383

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 368 IYRDSVYDD-----------KSGWGSV-----------AELINGKRRRGEAQSSYLDFKA--GHFCDVPpgFTPPIAQIQ 423
Cdd:PRK08506  384 VYRDDVYKEreekekekkakKEGKEERrihfqnksieeAEIIIGKNRNGPTGTVKLRFQKefTRFVDKP--IESHYEEGE 461


                  ....
gi 2427732019 424 AASA 427
Cdd:PRK08506  462 ETKA 465
dnaB_SPI-7_type NF040583
SPI-7-type island replicative DNA helicase; Members of this family are DnaB-PI, a ...
 74-394 1.16e-44

SPI-7-type island replicative DNA helicase; Members of this family are DnaB-PI, a pathogenicity island (PI) variant of the replicative DNA helicase DnaB. Members are found with other conjugative element replication proteins such as ParA, ParB in genetic islands whose core proteins (but not cargo proteins) are shared with the Salmonella typhi SPI-7 island.


Pssm-ID: 468557 [Multi-domain]  Cd Length: 434  Bit Score: 160.94  E-value: 1.16e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019  74 NLLAFAKKLADYHEcQRSVQAMKNVLANLNTATDcADVLLRLQKVASTIGRVTQGRQA--PLRIGTVMEGLLEDAERLAA 151
Cdd:NF040583   92 NIVAYAEIVAEYSR-ARQLLALGHDLSADASAPR-ADIADLLEQAEQRLFDIAEQAEPqqEVTLIEGLETLVSELELRCQ 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 152 SGQ-VEGYVTGCAGIDEAFGRLKGGDLVVIAARPGMGKTELALKI-----NKHIAQSVgcasLIVSLEMSHQQIGERLLS 225
Cdd:NF040583  170 SGNgITGTPTGFAELDEMTCGLQPGDLILLAARPSMGKTALALAFclgalRGKPDKVV----QIYSLEMPTEQLLMRLVS 245

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 226 DTSQLPVD-----VFDNPDLLSLESIMDKLrrsaEEYQDLPIyLQEVTNATHVDVCSSVRQFAEEVSNLGLLTIDHVGLH 300
Cdd:NF040583  246 MLGRVPLQrlrsgLLDDEDWARISQAMALL----TDWKDRLI-IDDTSYLTPALLRARARRNARKYGKPSLIMVDYLQLM 320

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 301 KTIGT-SRVEAVGDMTRAYKMLARELGIPVLLLCQLNRNLEMRDDKRPMLSDLRESGAIEQDADRIVFIYRDSVYDDKSG 379
Cdd:NF040583  321 RCPGQeNRTQEIAEISRSLKALAKEMGCPVLALSQLNRQLESRADKRPNNGDLRDSGALEQDADLIMFIYRDEVYNPNTP 400

                         330
                  ....*....|....*
gi 2427732019 380 WGSVAELINGKRRRG 394
Cdd:NF040583  401 DKGIAEIIIGKQRQG 415
 
Name Accession Description Interval E-value
DnaB_C cd00984
C-terminal domain of DnaB helicase; DnaB helicase C-terminal domain. The hexameric helicase ...
 157-410 1.01e-83

C-terminal domain of DnaB helicase; DnaB helicase C-terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This C-terminal domain contains an ATP-binding site and is therefore probably the site of ATP hydrolysis.


Pssm-ID: 410864 [Multi-domain]  Cd Length: 256  Bit Score: 257.44  E-value: 1.01e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 157 GYVTGCAGIDEAFGRLKGGDLVVIAARPGMGKTELALKINKHIAQSVGCASLIVSLEMSHQQIGERLLSDTSQLPVDVFD 236
Cdd:cd00984     1 GLPTGFTDLDKLTGGLQPGDLIIIAARPSMGKTAFALNIAENIALDEGLPVLFFSLEMSAEQLAERLLSSESGVSLSKLR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 237 NPdLLSLESiMDKLRRSAEEYQDLPIYLQEVTNATHVDVCSSVRQFAEEVSNLGLLTIDHVGL--HKTIGTSRVEAVGDM 314
Cdd:cd00984    81 TG-RLDDED-WERLTAAMGELSELPLYIDDTPGLTVDEIRAKARRLKREHGGLGLIVIDYLQLirGSKRAENRQQEVAEI 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 315 TRAYKMLARELGIPVLLLCQLNRNLEMRDDKRPMLSDLRESGAIEQDADRIVFIYRDSVYDDKSGWGSVAELINGKRRRG 394
Cdd:cd00984   159 SRSLKALAKELNVPVIALSQLNRGVESRTDKRPMLSDLRESGSIEQDADVVIFLYRDEYYDKDSEDKGIAEIIIAKNRNG 238

                         250
                  ....*....|....*...
gi 2427732019 395 EAQSSYLDFKAGH--FCD 410
Cdd:cd00984   239 PTGTVYLAFNPEYtrFTD 256
DnaB COG0305
Replicative DNA helicase [Replication, recombination and repair];
30-395 2.05e-80

Replicative DNA helicase [Replication, recombination and repair];


Pssm-ID: 440074 [Multi-domain]  Cd Length: 429  Bit Score: 255.00  E-value: 2.05e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019  30 AIEFLVDHETPVTQDTVAAYFRDMGHHE-------LAEwLVAELPLQEddgNLLAFAKKLADYHeCQRS-VQAMKNVLAN 101
Cdd:COG0305    42 AILDLYERGEPIDLVTVAEELEKRGELEevggaayLAE-LAENVPSAA---NIEYYARIVKEKA-LLRRlIEAGTEIVEL 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 102 -LNTATDCADVLlrlQKVASTIGRVTQGRQA--PLRIGTVMEGLLEDAERLAAS-GQVEGYVTGCAGIDEAFGRLKGGDL 177
Cdd:COG0305   117 aYDEDEDVDELL---DEAEQKIFEIAEKRSSkgFVSISDILKEALERIEELYKNgGGITGVPTGFTDLDKLTGGLQPGDL 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 178 VVIAARPGMGKTELALKINKHIAQSVGCASLIVSLEMSHQQIGERLLSDTSQLPVDVFDNPDLLSLEsiMDKLRRSAEEY 257
Cdd:COG0305   194 IILAARPSMGKTAFALNIARNAAIKEGKPVAIFSLEMSAEQLVMRLLSSEARIDSSKLRTGKLSDED--WERLSSAAGEL 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 258 QDLPIYLQEVTNATHVDVCSSVRQFAEEvSNLGLLTIDHVGLHK--TIGTSRVEAVGDMTRAYKMLARELGIPVLLLCQL 335
Cdd:COG0305   272 SEAPIYIDDTPGLTIAEIRAKARRLKRE-HGLGLIVIDYLQLMSgsGRSENRQQEISEISRSLKALAKELNVPVIALSQL 350

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 336 NRNLEMRDDKRPMLSDLRESGAIEQDADRIVFIYRDSVYDDKSGWGSVAELINGKRRRGE 395
Cdd:COG0305   351 SRAVEQRTDKRPQLSDLRESGSIEQDADVVMFLYRDEYYNPDSEDKGIAEIIIAKQRNGP 410
DnaB_C pfam03796
DnaB-like helicase C terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at ...
 160-395 5.31e-80

DnaB-like helicase C terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at the Escherichia coli chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This C-terminal domain contains an ATP-binding site and is therefore probably the site of ATP hydrolysis.


Pssm-ID: 427509 [Multi-domain]  Cd Length: 254  Bit Score: 247.71  E-value: 5.31e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 160 TGCAGIDEAFGRLKGGDLVVIAARPGMGKTELALKINKHIAQSVGCASLIVSLEMSHQQIGERLLSDTSQLPVDVFDNPD 239
Cdd:pfam03796   4 TGFTDLDRLTGGLQPGDLIIIAARPSMGKTAFALNIARNAAVKHKKPVAIFSLEMSAEQLVMRLLASEAGVDSQKLRTGQ 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 240 LLSLEsiMDKLRRSAEEYQDLPIYLQEVTNATHVDVCSSVRQFAEEvSNLGLLTIDHVGL--HKTIGTSRVEAVGDMTRA 317
Cdd:pfam03796  84 LTDED--WEKLAKAAGRLSEAPLYIDDTPGLSIAEIRAKARRLKRE-HGLGLIVIDYLQLmsGGSRGENRQQEISEISRS 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2427732019 318 YKMLARELGIPVLLLCQLNRNLEMRDDKRPMLSDLRESGAIEQDADRIVFIYRDSVYDDKSGwGSVAELINGKRRRGE 395
Cdd:pfam03796 161 LKALAKELNVPVIALSQLSRAVEQRTDKRPQLSDLRESGAIEQDADVVMFLYRDEYYNPKEP-EGKAEIIIAKQRNGP 237
DnaB TIGR00665
replicative DNA helicase; This model describes the helicase DnaB, a homohexameric protein ...
 30-394 9.15e-73

replicative DNA helicase; This model describes the helicase DnaB, a homohexameric protein required for DNA replication. The homohexamer can form a ring around a single strand of DNA near a replication fork. An intein of > 400 residues is found at a conserved location in DnaB of Synechocystis PCC6803, Rhodothermus marinus (both experimentally confirmed), and Mycobacterium tuberculosis. The intein removes itself by a self-splicing reaction. The seed alignment contains inteins so that the model built from the seed alignment will model a low cost at common intein insertion sites. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273206 [Multi-domain]  Cd Length: 432  Bit Score: 235.01  E-value: 9.15e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019  30 AIEFLVDHETPVTQDTVAAYFRDMGHHE-------LAEwLVAELPLQEddgNLLAFAKKLADyhecqRSV-----QAMKN 97
Cdd:TIGR00665  45 AILDLYEKGEPIDLVTVAEELEKDGELEevgglayLAE-LASNVPSAA---NIEYYAEIVKE-----KAIlrrliQAGTE 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019  98 VLANLNTATDCADVLLrlQKVASTIGRVTQGR--QAPLRIGTVMEGLLEDAERLAAS-GQVEGYVTGCAGIDEAFGRLKG 174
Cdd:TIGR00665 116 IVELAYDPTGDVEELL--DEAEQKIFEIAESRtsKGFKSIKEILKEAVEEIEELYERkGGITGVPTGFTDLDKLTSGLQP 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 175 GDLVVIAARPGMGKTELALKINKHIAQSVGCASLIVSLEMSHQQIGERLLSDTSQLPVDVFDNPDLLSLEsiMDKLRRSA 254
Cdd:TIGR00665 194 SDLIILAARPSMGKTAFALNIAENAAIKEGKPVAFFSLEMSAEQLVMRMLSSESRVDSQKLRTGRLSDED--WEKLTEAA 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 255 EEYQDLPIYLQEVTNATHVDVCSSVRQFAEEvSNLGLLTIDHVGL--HKTIGTSRVEAVGDMTRAYKMLARELGIPVLLL 332
Cdd:TIGR00665 272 GELSEAPLYIDDTPGLTITELRAKARRLKRE-HGLGLIVIDYLQLmsGSGRSENRQQEVSEISRSLKALAKELNVPVIAL 350

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2427732019 333 CQLNRNLEMRDDKRPMLSDLRESGAIEQDADRIVFIYRDSVYDDKSGWGSVAELINGKRRRG 394
Cdd:TIGR00665 351 SQLSRSVEQREDKRPQLSDLRESGSIEQDADIVMFLYRDEYYNPDSEDKGIAEIIIAKQRNG 412
phage_DnaB TIGR03600
phage replicative helicase, DnaB family, HK022 subfamily; Members of this family are phage (or ...
 88-403 1.10e-68

phage replicative helicase, DnaB family, HK022 subfamily; Members of this family are phage (or prophage-region) homologs of the bacterial homohexameric replicative helicase DnaB. Some phage may rely on host DnaB, while others encode their own verions. This model describes the largest phage-specific clade among the close homologs of DnaB, but there are, or course, other DnaB homologs from phage that fall outside the scope of this model. [Mobile and extrachromosomal element functions, Prophage functions]


Pssm-ID: 274672 [Multi-domain]  Cd Length: 420  Bit Score: 224.20  E-value: 1.10e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019  88 CQRSVQamknvLANLNTATDCADVLLRLQKVASTIGRVTQGRQAPLRIGTVMEGLLEDAE-RLAASGQVEGYVTGCAGID 166
Cdd:TIGR03600 110 CQRIIT-----LACSPDGGTAEQKVEEAQAALLALTMSDGQEDGFVTFGEVLEDVVRDLDkRFNPKGELTGLSTGLPKLD 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 167 EAFGRLKGGDLVVIAARPGMGKTELALKINKHIAQSVGCASLIVSLEMSHQQIGERLLSDTSQLPVDVFDNPDLLSLEsi 246
Cdd:TIGR03600 185 RLTNGLVKGDLIVIGARPSMGKTTLALNIAENVALREGKPVLFFSLEMSAEQLGERLLASKSGINTGNIRTGRFNDSE-- 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 247 MDKLRRSAEEYQDLPIYLQEVTNATHVDVCSSVRQFAEEVSNLGLLTIDHVGL-HKTIGTSRVEAVGDMTRAYKMLAREL 325
Cdd:TIGR03600 263 FNRLLNAVDRLSEKDLYIDDTGGLTVAQIRSIARRIKRKKGGLDLIVVDYIQLmAPARGRDRNEELGGISRGLKALAKEL 342

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2427732019 326 GIPVLLLCQLNRNLEMRDDKRPMLSDLRESGAIEQDADRIVFIYRDSVYDDKSGWGSVAELINGKRRRGEAQSSYLDF 403
Cdd:TIGR03600 343 DVPVVLLAQLNRGSEKRTDKRPIMSDLRDSGAIEQDADVIGLIHREGYYDAREPPAGIAELILAKNRHGPTGTVELLF 420
PRK08506 PRK08506
replicative DNA helicase; Provisional
 138-427 3.99e-58

replicative DNA helicase; Provisional


Pssm-ID: 236278 [Multi-domain]  Cd Length: 472  Bit Score: 197.93  E-value: 3.99e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 138 VMEGLLEDAERLAASGQvegyvTGCAGIDEAFGRL-------KGGDLVVIAARPGMGKTELALK-INKHIAQSVGCAslI 209
Cdd:PRK08506  153 VIESTMEHIKKQKRLGN-----KDIIGLDTGFVELnkmtkgfNKGDLIIIAARPSMGKTTLCLNmALKALNQDKGVA--F 225

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 210 VSLEMSHQQIGERLLSDTSQLPVDVFDNPDLLSLEsiMDKLRRSAEEYQDLPIYLQEVTNATHVDVCSSVRQFAEEVSNL 289
Cdd:PRK08506  226 FSLEMPAEQLMLRMLSAKTSIPLQNLRTGDLDDDE--WERLSDACDELSKKKLFVYDSGYVNIHQVRAQLRKLKSQHPEI 303

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 290 GLLTIDHVGLHKTIG--TSRVEAVGDMTRAYKMLARELGIPVLLLCQLNRNLEMRDDKRPMLSDLRESGAIEQDADRIVF 367
Cdd:PRK08506  304 GLAVIDYLQLMSGSGnfKDRHLQISEISRGLKLLARELDIPIIALSQLNRSLESRADKRPMLSDLRESGAIEQDADIILF 383

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 368 IYRDSVYDD-----------KSGWGSV-----------AELINGKRRRGEAQSSYLDFKA--GHFCDVPpgFTPPIAQIQ 423
Cdd:PRK08506  384 VYRDDVYKEreekekekkakKEGKEERrihfqnksieeAEIIIGKNRNGPTGTVKLRFQKefTRFVDKP--IESHYEEGE 461


                  ....
gi 2427732019 424 AASA 427
Cdd:PRK08506  462 ETKA 465
PRK08840 PRK08840
replicative DNA helicase; Provisional
 126-407 7.77e-55

replicative DNA helicase; Provisional


Pssm-ID: 181562 [Multi-domain]  Cd Length: 464  Bit Score: 189.04  E-value: 7.77e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 126 TQGRQAPLRIGTVMEGLLEDAERLAASGQ--VEGYVTGCAGIDEAFGRLKGGDLVVIAARPGMGKTELALKINKHIAQSV 203
Cdd:PRK08840  166 TSENEGPQNVDSILEKTLERIELLYKTPQdgVTGVDTGFTDLNKKTAGLQGSDLIIVAARPSMGKTTFAMNLCENAAMDQ 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 204 GCASLIVSLEMSHQQIGERLLS-----DTSQLPVDVFDNPDLLSLESIMDKLRRSAEeyqdlpIYLQEVTNATHVDVCSS 278
Cdd:PRK08840  246 DKPVLIFSLEMPAEQLMMRMLAslsrvDQTKIRTGQLDDEDWARISSTMGILMEKKN------MYIDDSSGLTPTEVRSR 319

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 279 VRQFAEEVSNLGLLTIDHVGLHKTIGTS--RVEAVGDMTRAYKMLARELGIPVLLLCQLNRNLEMRDDKRPMLSDLRESG 356
Cdd:PRK08840  320 ARRIAREHGGLSMIMVDYLQLMRVPALSdnRTLEIAEISRSLKALAKELNVPVVALSQLNRSLEQRADKRPVNSDLRESG 399

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2427732019 357 AIEQDADRIVFIYRDSVYDDKSGWGSVAELINGKRRRGEAQSSYLDFKAGH 407
Cdd:PRK08840  400 SIEQDADLIMFIYRDEVYNPDSPLKGTAEIIIGKQRNGPIGSVRLTFQGQY 450
PRK05748 PRK05748
replicative DNA helicase; Provisional
 129-394 1.44e-53

replicative DNA helicase; Provisional


Pssm-ID: 180232 [Multi-domain]  Cd Length: 448  Bit Score: 185.16  E-value: 1.44e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 129 RQAPLRIGTVMEGLLEDAERLA-ASGQVEGYVTGCAGIDEAFGRLKGGDLVVIAARPGMGKTELALKINKHIAQSVGCAS 207
Cdd:PRK05748  156 KSGFKNIKDVLVKAYDRIEMLHnQTGDITGIPTGFTDLDKMTSGLQPNDLIIVAARPSVGKTAFALNIAQNVATKTDKNV 235

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 208 LIVSLEMSHQQIGERLLS-----DTSQLPVDVFDNPDLLSLESIMDKLrrsaeeyQDLPIYLQEVTNATHVDVCSSVRQF 282
Cdd:PRK05748  236 AIFSLEMGAESLVMRMLCaegniDAQRLRTGQLTDDDWPKLTIAMGSL-------SDAPIYIDDTPGIKVTEIRARCRRL 308

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 283 AEEVSNLGLLTIDHVGLHKTIGTS---RVEAVGDMTRAYKMLARELGIPVLLLCQLNRNLEMRDDKRPMLSDLRESGAIE 359
Cdd:PRK05748  309 AQEHGGLGLILIDYLQLIQGSGRSgenRQQEVSEISRSLKALAKELKVPVIALSQLSRGVEQRQDKRPVMSDIRESGSIE 388

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 2427732019 360 QDADRIVFIYRDSVYDDKSGWGSVAELINGKRRRG 394
Cdd:PRK05748  389 QDADIVAFLYRDDYYDEETENKNTIEIIIAKQRNG 423
PRK07004 PRK07004
replicative DNA helicase; Provisional
 127-403 1.21e-51

replicative DNA helicase; Provisional


Pssm-ID: 235907 [Multi-domain]  Cd Length: 460  Bit Score: 180.49  E-value: 1.21e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 127 QGRQAPLRIGTVMEGLLEDAERL---AASGQVEGYVTGCAGIDEAFGRLKGGDLVVIAARPGMGKTELALKINKHIAQSV 203
Cdd:PRK07004  162 RGTQGFLEIGPLLTQVVERIDTLyhtANPSDVTGTPTGFVDLDRMTSGMHGGELIIVAGRPSMGKTAFSMNIGEYVAVEY 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 204 GCASLIVSLEMSHQQIGERLLSDTSQLPVDVFDNPDLLSLEsiMDKLRRSAEEYQDLPIYLQEVTNATHVDVCSSVRQFA 283
Cdd:PRK07004  242 GLPVAVFSMEMPGTQLAMRMLGSVGRLDQHRMRTGRLTDED--WPKLTHAVQKMSEAQLFIDETGGLNPMELRSRARRLA 319

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 284 EEVSNLGLLTIDHVGLH--KTIGTSRVEAVGDMTRAYKMLARELGIPVLLLCQLNRNLEMRDDKRPMLSDLRESGAIEQD 361
Cdd:PRK07004  320 RQCGKLGLIIIDYLQLMsgSSQGENRATEISEISRSLKSLAKELDVPVIALSQLNRGLEQRPNKRPVMSDLRESGAIEQD 399

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 2427732019 362 ADRIVFIYRDSVYDDKSGWGSVAELINGKRRRGEAQSSYLDF 403
Cdd:PRK07004  400 ADVILFIYRDEVYNPDSPDKGTAEIIIGKQRNGPIGPVRLTF 441
PRK08006 PRK08006
replicative DNA helicase DnaB;
130-403 1.36e-50

replicative DNA helicase DnaB;


Pssm-ID: 181193 [Multi-domain]  Cd Length: 471  Bit Score: 177.89  E-value: 1.36e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 130 QAPLRIGTVMEGLLEDAERLAASGQ--VEGYVTGCAGIDEAFGRLKGGDLVVIAARPGMGKTELALKINKHIAQSVGCAS 207
Cdd:PRK08006  177 EGPKNIADILDATVARIEQLFQQPHdgVTGVNTGYDDLNKKTAGLQPSDLIIVAARPSMGKTTFAMNLCENAAMLQDKPV 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 208 LIVSLEMSHQQIGERLLS-----DTSQLPVDVFDNPDLLSLESIMDKLRRSAEeyqdlpIYLQEVTNATHVDVCSSVRQF 282
Cdd:PRK08006  257 LIFSLEMPGEQIMMRMLAslsrvDQTRIRTGQLDDEDWARISGTMGILLEKRN------MYIDDSSGLTPTEVRSRARRI 330

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 283 AEEVSNLGLLTIDHVGLHK--TIGTSRVEAVGDMTRAYKMLARELGIPVLLLCQLNRNLEMRDDKRPMLSDLRESGAIEQ 360
Cdd:PRK08006  331 FREHGGLSLIMIDYLQLMRvpSLSDNRTLEIAEISRSLKALAKELQVPVVALSQLNRSLEQRADKRPVNSDLRESGSIEQ 410

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 2427732019 361 DADRIVFIYRDSVYDDKSGWGSVAELINGKRRRGEAQSSYLDF 403
Cdd:PRK08006  411 DADLIMFIYRDEVYHENSDLKGIAEIIIGKQRNGPIGTVRLTF 453
PRK08760 PRK08760
replicative DNA helicase; Provisional
 137-407 4.06e-50

replicative DNA helicase; Provisional


Pssm-ID: 181547 [Multi-domain]  Cd Length: 476  Bit Score: 176.65  E-value: 4.06e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 137 TVMEGLLEDA-----ERLAASGQVEGYVTGCAGIDEAFGRLKGGDLVVIAARPGMGKTELALKINKHIAQSVGCASLIVS 211
Cdd:PRK08760  186 VAMPGALKDAfeelrNRFENGGNITGLPTGYNDFDAMTAGLQPTDLIILAARPAMGKTTFALNIAEYAAIKSKKGVAVFS 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 212 LEMSHQQIGERLLS-----DTSQLPVDVFDNPDLLSLESIMDKLRRSAEEYQDLPIYLQEVTNathvdvcSSVRQFAEEv 286
Cdd:PRK08760  266 MEMSASQLAMRLISsngriNAQRLRTGALEDEDWARVTGAIKMLKETKIFIDDTPGVSPEVLR-------SKCRRLKRE- 337

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 287 SNLGLLTIDHVGLHKTIGTS--RVEAVGDMTRAYKMLARELGIPVLLLCQLNRNLEMRDDKRPMLSDLRESGAIEQDADR 364
Cdd:PRK08760  338 HDLGLIVIDYLQLMSVPGNSenRATEISEISRSLKGLAKELNVPVIALSQLNRSLETRTDKRPVMADLRESGAIEQDADM 417

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 2427732019 365 IVFIYRDSVYD-DKSGWGSVAELINGKRRRGEAQSSYLDFKAGH 407
Cdd:PRK08760  418 IVFIYRDDYYNkENSPDKGLAEIIIGKHRGGPTGSCKLKFFGEY 461
PRK06904 PRK06904
replicative DNA helicase; Validated
 23-404 2.87e-48

replicative DNA helicase; Validated


Pssm-ID: 136106 [Multi-domain]  Cd Length: 472  Bit Score: 171.72  E-value: 2.87e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019  23 EYRSVRVAIEFLVDHETPVTQDTVAAYFRDMGHHE-------LAEwLVAELPlqeDDGNLLAFAKKLADYHECQRSVQAM 95
Cdd:PRK06904   60 EHRIIFQEMELLFRQNTPIDLLTLDQALKTKGKSDevggfayLAE-LSNNTP---SAANILAYADIVREKAILRELISVG 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019  96 KNVLANLNT--ATDCADVLLRLQKVASTIG-RVTQGRQAPLRIGTVMEGLLEDAERLAA---SGQVEGYVTGCAGIDEAF 169
Cdd:PRK06904  136 NNIAKNAYSpkGQDIKDILDEAERDVFSIAeKRTTANEGPQNVINLLENTIDKIENLAAtptNNGVTGVTTGFTDLDKKT 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 170 GRLKGGDLVVIAARPGMGKTELALKINKHIAQSVGCASLIVSLEMSHQQIGERLLSDTSQlpVD--------VFDNPDLL 241
Cdd:PRK06904  216 AGLQPSDLIIVAARPSMGKTTFAMNLCENAAMASEKPVLVFSLEMPAEQIMMRMLASLSR--VDqtkirtgqNLDQQDWA 293

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 242 SLESIMDKLRRSAEeyqdlpIYLQEVTNATHVDVCSSVRQFAEEVSNLGLLTIDHVGLHKTIGTS--RVEAVGDMTRAYK 319
Cdd:PRK06904  294 KISSTVGMFKQKPN------LYIDDSSGLTPTELRSRARRVYRENGGLSLIMVDYLQLMRAPGFEdnRTLEIAEISRSLK 367

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 320 MLARELGIPVLLLCQLNRNLEMRDDKRPMLSDLRESGAIEQDADRIVFIYRDSVYDDKS-GWGSVAELINGKRRRGEAQS 398
Cdd:PRK06904  368 ALAKELKVPVVALSQLNRTLENRGDKRPVNSDLRESGSIEQDADLIMFIYRDEVYNETTeDNKGVAEIIIGKQRNGPIGR 447


                  ....*.
gi 2427732019 399 SYLDFK 404
Cdd:PRK06904  448 VRLAFQ 453
PRK09165 PRK09165
replicative DNA helicase; Provisional
 114-374 1.37e-46

replicative DNA helicase; Provisional


Pssm-ID: 181676 [Multi-domain]  Cd Length: 497  Bit Score: 167.75  E-value: 1.37e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 114 RLQKVASTiGRVTQGRQaplRIGTVMEGLLEDAER-LAASGQVEGYVTGCAGIDEAFGRLKGGDLVVIAARPGMGKTELA 192
Cdd:PRK09165  159 KLYELAET-GRYEGGFQ---SFGTAITEAVDMANAaFKRDGHLSGISTGLRDLDSKLGGLHPSDLIILAGRPSMGKTALA 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 193 LKI------------------NKHIAQSVGcaslIVSLEMSHQQIGERLLSDTSQLPVDVFDNPDLLslESIMDKLRRSA 254
Cdd:PRK09165  235 TNIafnaakayrreaqpdgskKAVNGGVVG----FFSLEMSAEQLATRILSEQSEISSSKIRRGKIS--EEDFEKLVDAS 308

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 255 EEYQDLPIYLQEvTNATHVdvcSSVRQFAEEVS---NLGLLTIDHVGL----HKTIGTSRVEAVGDMTRAYKMLARELGI 327
Cdd:PRK09165  309 QELQKLPLYIDD-TPALSI---SQLRARARRLKrqhGLDLLVVDYLQLirgsSKRSSDNRVQEISEITQGLKALAKELNI 384

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 2427732019 328 PVLLLCQLNRNLEMRDDKRPMLSDLRESGAIEQDADRIVFIYRDSVY 374
Cdd:PRK09165  385 PVIALSQLSRQVEQRDDKRPQLSDLRESGSIEQDADVVMFVYREEYY 431
dnaB_SPI-7_type NF040583
SPI-7-type island replicative DNA helicase; Members of this family are DnaB-PI, a ...
 74-394 1.16e-44

SPI-7-type island replicative DNA helicase; Members of this family are DnaB-PI, a pathogenicity island (PI) variant of the replicative DNA helicase DnaB. Members are found with other conjugative element replication proteins such as ParA, ParB in genetic islands whose core proteins (but not cargo proteins) are shared with the Salmonella typhi SPI-7 island.


Pssm-ID: 468557 [Multi-domain]  Cd Length: 434  Bit Score: 160.94  E-value: 1.16e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019  74 NLLAFAKKLADYHEcQRSVQAMKNVLANLNTATDcADVLLRLQKVASTIGRVTQGRQA--PLRIGTVMEGLLEDAERLAA 151
Cdd:NF040583   92 NIVAYAEIVAEYSR-ARQLLALGHDLSADASAPR-ADIADLLEQAEQRLFDIAEQAEPqqEVTLIEGLETLVSELELRCQ 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 152 SGQ-VEGYVTGCAGIDEAFGRLKGGDLVVIAARPGMGKTELALKI-----NKHIAQSVgcasLIVSLEMSHQQIGERLLS 225
Cdd:NF040583  170 SGNgITGTPTGFAELDEMTCGLQPGDLILLAARPSMGKTALALAFclgalRGKPDKVV----QIYSLEMPTEQLLMRLVS 245

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 226 DTSQLPVD-----VFDNPDLLSLESIMDKLrrsaEEYQDLPIyLQEVTNATHVDVCSSVRQFAEEVSNLGLLTIDHVGLH 300
Cdd:NF040583  246 MLGRVPLQrlrsgLLDDEDWARISQAMALL----TDWKDRLI-IDDTSYLTPALLRARARRNARKYGKPSLIMVDYLQLM 320

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 301 KTIGT-SRVEAVGDMTRAYKMLARELGIPVLLLCQLNRNLEMRDDKRPMLSDLRESGAIEQDADRIVFIYRDSVYDDKSG 379
Cdd:NF040583  321 RCPGQeNRTQEIAEISRSLKALAKEMGCPVLALSQLNRQLESRADKRPNNGDLRDSGALEQDADLIMFIYRDEVYNPNTP 400

                         330
                  ....*....|....*
gi 2427732019 380 WGSVAELINGKRRRG 394
Cdd:NF040583  401 DKGIAEIIIGKQRQG 415
PRK05595 PRK05595
replicative DNA helicase; Provisional
 135-394 4.41e-44

replicative DNA helicase; Provisional


Pssm-ID: 235525 [Multi-domain]  Cd Length: 444  Bit Score: 159.99  E-value: 4.41e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 135 IGTVMEGLLEDAERLAA-SGQVEGYVTGCAGIDEAFGRLKGGDLVVIAARPGMGKTELALKINKHIAQSVGCASLIVSLE 213
Cdd:PRK05595  160 LSNVLERGFEQIENLFNnKGETTGVASGFRELDAKTSGFQKGDMILIAARPSMGKTTFALNIAEYAALREGKSVAIFSLE 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 214 MSHQQIGERLLSDTSqlpvdvfdNPDLLSLE--SIMDK----LRRSAEEYQDLPIYLQEVTNATHVDVCSSVRQFAEEvS 287
Cdd:PRK05595  240 MSKEQLAYKLLCSEA--------NVDMLRLRtgNLEDKdwenIARASGPLAAAKIFIDDTAGVSVMEMRSKCRRLKIE-H 310

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 288 NLGLLTIDHVGLHKTIGT--SRVEAVGDMTRAYKMLARELGIPVLLLCQLNRNLEMRDDKRPMLSDLRESGAIEQDADRI 365
Cdd:PRK05595  311 GIDMILIDYLQLMSGGKGseSRQQEVSEISRSIKALAKEMECPVIALSQLSRAPEQRADHRPMLSDLRESGSIEQDADVV 390

                         250       260
                  ....*....|....*....|....*....
gi 2427732019 366 VFIYRDSVYDDKSGWGSVAELINGKRRRG 394
Cdd:PRK05595  391 MFLYRDEYYNKETEDKNVAECIIAKQRNG 419
PRK07773 PRK07773
replicative DNA helicase; Validated
 17-361 5.78e-44

replicative DNA helicase; Validated


Pssm-ID: 236093 [Multi-domain]  Cd Length: 886  Bit Score: 164.54  E-value: 5.78e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019  17 VEAFCDE-YRSVRVAIEFLVDHETPVTQDTVAAYFRDMGHHEL---AEWLVAELPLQEDDGNLLAFAKKLADYHECQRSV 92
Cdd:PRK07773   54 PGAFYRPaHQNIYDAILDLYGRGEPADLVTVAAELDRRGLLERiggAPYLHTLISTVPTAANADYYARIVAEKALLRRLI 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019  93 QAMKNVLA-NLNTATDCADVLLRLQKvasTIGRVTQGR-QAPLR-IGTVMEGLLEDAERLAASG-QVEGYVTGCAGIDEA 168
Cdd:PRK07773  134 EAGTRIVQyGYAEGADVAEVVDRAQA---EIYDVTDRRlSEDFVaLEDLLQPTFDEIDAIASSGgLARGVPTGFTELDAM 210

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 169 FGRLKGGDLVVIAARPGMGKTELALKINKHIAQSVGCASLIVSLEMSHQQIGERLLSDTSQLPVDVFDNPDLLSLEsiMD 248
Cdd:PRK07773  211 TNGLHPGQLIIVAARPSMGKTTFGLDFARNCAIRHRLAVAIFSLEMSKEQLVMRLLSAEAKIKLSDMRSGRMSDDD--WT 288

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 249 KLRRSAEEYQDLPIYLQEVTNATHVDVCSSVRQFAEEVsNLGLLTIDHVGLHKT--IGTSRVEAVGDMTRAYKMLARELG 326
Cdd:PRK07773  289 RLARAMGEISEAPIFIDDTPNLTVMEIRAKARRLRQEA-NLGLIVVDYLQLMTSgkKYENRQQEVSEISRHLKLLAKELE 367

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 2427732019 327 IPVLLLCQLNRNLEMRDDKRPMLSDLRESGAIEQD 361
Cdd:PRK07773  368 VPVVALSQLSRGVEQRTDKRPMLSDLRESGCLTGD 402
PRK06749 PRK06749
replicative DNA helicase; Provisional
 152-403 3.66e-43

replicative DNA helicase; Provisional


Pssm-ID: 168658 [Multi-domain]  Cd Length: 428  Bit Score: 157.03  E-value: 3.66e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 152 SGQVEGYVTGCAGIDEAFGRLKGGDLVVIAARPGMGKTELALKINKHIAQSvGCASLIVSLEMSHQQIGERLLSDTSQLP 231
Cdd:PRK06749  163 AKEITGIETGYTSLNKMTCGLQEGDFVVLGARPSMGKTAFALNVGLHAAKS-GAAVGLFSLEMSSKQLLKRMASCVGEVS 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 232 VDVFDNPDLLSLESIMDKLRRSAEEYQDLPIYLQEVTNATHVDVCSSVRQFAEEVSNLGLLTI-DHVGL------HKTig 304
Cdd:PRK06749  242 GGRLKNPKHRFAMEDWEKVSKAFAEIGELPLEIYDNAGVTVQDIWMQTRKLKRKHGDKKILIIvDYLQLitgdpkHKG-- 319

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 305 tSRVEAVGDMTRAYKMLARELGIPVLLLCQLNRNLEMRDDKRPMLSDLRESGAIEQDADRIVFIYRDSVYDDKSGWGSVA 384
Cdd:PRK06749  320 -NRFQEISEISRKLKLLARELNVCVVALSQLSRSVESRQDKRPLLSDLRETGQIEQDADVIMLMYREDYYDKETMQKEMT 398

                         250
                  ....*....|....*....
gi 2427732019 385 ELINGKRRRGEAQSSYLDF 403
Cdd:PRK06749  399 EIHVAKHRNGPVGSFKLRF 417
PRK05636 PRK05636
replicative DNA helicase; Provisional
 143-394 4.01e-38

replicative DNA helicase; Provisional


Pssm-ID: 180177 [Multi-domain]  Cd Length: 505  Bit Score: 144.60  E-value: 4.01e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 143 LEDAERLAASGQVE-GYVTGCAGIDEAFGRLKGGDLVVIAARPGMGKTELALKINKHIAQSVGCASLIVSLEMSHQQIGE 221
Cdd:PRK05636  232 MDELEMLSSQGGIAtGIPTGFKDLDDLTNGLRGGQMIIVAARPGVGKSTLALDFMRSASIKHNKASVIFSLEMSKSEIVM 311

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 222 RLLSDTSQLPVDVFDNPDLLslESIMDKLRRSAEEYQDLPIYLQEVTNATHVDVCSSVRQFAEEVsNLGLLTIDHVGLHK 301
Cdd:PRK05636  312 RLLSAEAEVRLSDMRGGKMD--EDAWEKLVQRLGKIAQAPIFIDDSANLTMMEIRSKARRLKQKH-DLKLIVVDYLQLMS 388

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 302 TiGT---SRVEAVGDMTRAYKMLARELGIPVLLLCQLNRNLEMRDDKRPMLSDLRESGAIEQDADRIVFIYR-DSVYDDK 377
Cdd:PRK05636  389 S-GKrveSRQQEVSEFSRQLKLLAKELDVPLIAISQLNRGPESRTDKRPQLADLRESGSLEQDADMVMLLYRpDSQDKDD 467

                         250
                  ....*....|....*..
gi 2427732019 378 SGWGSvAELINGKRRRG 394
Cdd:PRK05636  468 ERAGE-ADIILAKHRGG 483
PRK06321 PRK06321
replicative DNA helicase; Provisional
 142-404 1.49e-37

replicative DNA helicase; Provisional


Pssm-ID: 180528 [Multi-domain]  Cd Length: 472  Bit Score: 142.67  E-value: 1.49e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 142 LLEDAERLAASGQ------VEGYVTGCAGIDEAFGRLKGGDLVVIAARPGMGKTELALKINKHIAQSVGCASLIVSLEMS 215
Cdd:PRK06321  187 LQERQEAFQQSAQgdsspmISGIPTHFIDLDKMINGFSPSNLMILAARPAMGKTALALNIAENFCFQNRLPVGIFSLEMT 266

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 216 HQQIGERLLSDTSQLPVDVFDNPDLLSLEsiMDKLRRSAEEYQDLPIYLQEVTNATHVDVCSSVRQFaEEVSNLGLLTID 295
Cdd:PRK06321  267 VDQLIHRIICSRSEVESKKISVGDLSGRD--FQRIVSVVNEMQEHTLLIDDQPGLKITDLRARARRM-KESYDIQFLIID 343

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 296 HVGLHKTIGT-----SRVEAVGDMTRAYKMLARELGIPVLLLCQLNRNLEMRDDKRPMLSDLRESGAIEQDADRIVFIYR 370
Cdd:PRK06321  344 YLQLLSGSGNlrnseSRQTEISEISRMLKNLARELNIPILCLSQLSRKVEDRANHRPMMSDLRESGSIEQDSDLVMFLLR 423

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 2427732019 371 DSVYD--DKSGwgsVAELINGKRRRGEAQSSYLDFK 404
Cdd:PRK06321  424 REYYDpnDKPG---TAELIVAKNRHGSIGSVPLVFE 456
PRK05973 PRK05973
replicative DNA helicase; Provisional
 167-353 6.21e-09

replicative DNA helicase; Provisional


Pssm-ID: 168322 [Multi-domain]  Cd Length: 237  Bit Score: 56.20  E-value: 6.21e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 167 EAFGRLKGGDLVVIAARPGMGKTELALKINKHIAQSvGCASLIVSLEMSHQQIGERLLS---DTSQL-PVDVFDNPDLLS 242
Cdd:PRK05973   56 ELFSQLKPGDLVLLGARPGHGKTLLGLELAVEAMKS-GRTGVFFTLEYTEQDVRDRLRAlgaDRAQFaDLFEFDTSDAIC 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 243 LESIMDKLrRSAEEYQDLPI-YLQEV-TNATHVDVCSSVrqfaeevsnlglltidhvglhktigtsrveavgdmtRAYKM 320
Cdd:PRK05973  135 ADYIIARL-ASAPRGTLVVIdYLQLLdQRREKPDLSVQV------------------------------------RALKS 177

                         170       180       190
                  ....*....|....*....|....*....|...
gi 2427732019 321 LARELGIPVLLLCQLNRNLEMRDDKRPMLSDLR 353
Cdd:PRK05973  178 FARERGLIIVFISQIDRSFDPSAKPLPDIRDVR 210
RecA-like_Gp4D_helicase cd19483
RecA-like domain of Escherichia coli bacteriophage T7 Gp4D helicase; This family includes the ...
 178-371 1.01e-06

RecA-like domain of Escherichia coli bacteriophage T7 Gp4D helicase; This family includes the RecA-like domain of the Gp4D fragment of the Gene4 helicase-primase (Gp4) from bacteriophage T7. Gp4D (residues 241-566) is the minimal fragment of the Gp4 that forms hexameric rings, it contains the helicase domain and the linker connecting the helicase and primase domains. Helicases are ring-shaped oligomeric enzymes that unwind DNA at the replication fork; they couple NTP hydrolysis to the unwinding of nucleic acid duplexes into their component strands. This family belongs to the RecA-like NTPase superfamily which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410891 [Multi-domain]  Cd Length: 231  Bit Score: 49.49  E-value: 1.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 178 VVIAARPGMGKTELALKINKHIA----QSVGcaslIVSLEMSHQQIGERLLSdtsqLPVDVFDNPDLLSLESIMDKLR-- 251
Cdd:cd19483     1 VTIGAGSGIGKSTIVRELAYHLItehgEKVG----IISLEESVEETAKGLAG----KHLGKPEPLELPRDDITEEEEDda 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 252 RSAEEYQDLPIYLQEVTNAThVDVCSSVRQFAEEVSNLGLLTIDHVglhkTI---GTSRVEAVGD----MTRAyKMLARE 324
Cdd:cd19483    73 FDNELGSGRFFLYDHFGSLD-WDNLKEKIRYMVKVLGCKVIVLDHL----TIlvsGLDSSDERKEldeiMTEL-AALVKE 146

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2427732019 325 LGIPVLLLCQLNR---NLEMRDDKRPMLSDLRESGAIEQDADRIVFIYRD 371
Cdd:cd19483   147 LGVTIILVSHLRRpggGKGHEEGGEVSESDLRGSSAIAQLSDYVIGLERN 196
RAD55 COG0467
RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms];
160-257 2.28e-05

RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms];


Pssm-ID: 440235 [Multi-domain]  Cd Length: 221  Bit Score: 45.29  E-value: 2.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 160 TGCAGIDEAF-GRLKGGDLVVIAARPGMGKTELALKINKHIAQSvGCASLIVSLEMSHQQIGERLLS---DTSQLP---- 231
Cdd:COG0467     4 TGIPGLDELLgGGLPRGSSTLLSGPPGTGKTTLALQFLAEGLRR-GEKGLYVSFEESPEQLLRRAESlglDLEEYIesgl 82

                          90       100
                  ....*....|....*....|....*....
gi 2427732019 232 ---VDVFDNPDLLSLESIMDKLRRSAEEY 257
Cdd:COG0467    83 lriIDLSPEELGLDLEELLARLREAVEEF 111
PRK07773 PRK07773
replicative DNA helicase; Validated
 357-407 2.69e-05

replicative DNA helicase; Validated


Pssm-ID: 236093 [Multi-domain]  Cd Length: 886  Bit Score: 46.67  E-value: 2.69e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2427732019 357 AIEQDADRIVFIYRDSVYDDKSGWGSVAELINGKRRRGEAQSSYLDFKAGH 407
Cdd:PRK07773  827 SIEQDADVVILLYRPDYYDRDDPRGGEAEFIVAKHRNGPTGTVTLAFQLHL 877
RadA_SMS_N cd01121
bacterial RadA DNA repair protein; Sms or bacterial RadA is a DNA repair protein that plays a ...
 164-246 3.65e-03

bacterial RadA DNA repair protein; Sms or bacterial RadA is a DNA repair protein that plays a role in recombination and recombinational repair of DNA damaged by UV radiation, X-rays, and chemical agent and is responsible for the stabilization or processing of branched DNA molecules.


Pssm-ID: 410866 [Multi-domain]  Cd Length: 268  Bit Score: 39.05  E-value: 3.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 164 GIDEaFGRLKGGDLV-----VIAARPGMGKTELALKINKHIAQSVGcASLIVSLEMSHQQIG---ERLLSDTSQLPV--- 232
Cdd:cd01121    67 GIGE-LDRVLGGGLVpgsvvLIGGDPGIGKSTLLLQVAARLAQRGG-KVLYVSGEESLSQIKlraERLGLGSDNLYLlae 144

                          90       100
                  ....*....|....*....|...
gi 2427732019 233 ----DVFD-----NPDLLSLESI 246
Cdd:cd01121   145 tnleAILAeieelKPSLVVIDSI 167
RepA COG3598
RecA-family ATPase [Replication, recombination and repair];
170-258 6.08e-03

RecA-family ATPase [Replication, recombination and repair];


Pssm-ID: 442817 [Multi-domain]  Cd Length: 313  Bit Score: 38.73  E-value: 6.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427732019 170 GRLKGGDLVVIAARPGMGKTELALKINKHIA--------QSVGCASLIVSLEMSHQQIGERL---LSDTSQLPVDVFDNP 238
Cdd:COG3598     8 GLLPEGGVTLLAGPPGTGKSFLALQLAAAVAaggpwlgrRVPPGKVLYLAAEDDRGELRRRLkalGADLGLPFADLDGRL 87

                          90       100
                  ....*....|....*....|....*.
gi 2427732019 239 DLLSL------ESIMDKLRRSAEEYQ 258
Cdd:COG3598    88 RLLSLagdlddTDDLEALERAIEEEG 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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